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202. Costs Associated With Timely and Delayed Surgical Treatment of Spinal Metastases.

Author

van Tol, Floris R., Massier, Julie R. A., Frederix, Geert W. J., Öner, F. Cumhur, Verkooijen, Helena M., and Verlaan, Jorrit-Jan

Subjects
SPINAL injury treatment, RETROSPECTIVE studies, NEUROLOGICAL disorders, MEDICAL care costs, TREATMENT effectiveness
Abstract

Study Design: Retrospective cohort study. Objectives: Symptoms caused by spinal metastases are often difficult to distinguish from symptoms caused by non-malignant spinal disease, complicating timely diagnosis, referral and treatment. The ensuing delays may promote the risk of neurological deficits or severe mechanical instability and consequent emergency surgery, leading to poorer prognosis. Presumably, treatment delay may subsequently lead to more health-care consumption and therefore increased average costs of treatment. Methods: All patients surgically treated for spinal metastases were included in the current study. Based on the presence of alarming symptoms and urgency of the required intervention, patients were categorized as having received timely or delayed treatment. Pre-surgical, in-hospital, aftercare and total costs were analyzed and compared between the 2 groups. Results: In total, 299 patients were included, of which 205 underwent timely and 94 delayed treatment. There was no significant difference in pre-surigcal costs (€3.229,13 in the timely treated group vs. €2.528,70 in the delayed treatment group, p = 0.849). The in-hospital costs (€16.738,49 vs. €13.108,81, p < 0.001) and the aftercare costs (€13.950,37 vs. 3.981,93, p < 0.001) were significantly higher for delayed treatment vs. timely treatment, respectively. The total costs were €33.741,71 for delayed treatment and €20.318,52 for timely treatment (p < 0.001). Conclusions: The total costs for timely treated patients with spinal metastases are significantly lower compared with patients receiving delayed treatment. Investing in the optimization of referral patterns may therefore reduce the overall pretreatment delay and subsequently increase patient outcome, leading to better clinical outcomes at lower costs. [ABSTRACT FROM AUTHOR]

Published
2022
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205. Problems and Promises of Introducing the Magnetic Resonance Imaging Linear Accelerator Into Routine Care: The Case of Prostate Cancer

Author

Hehakaya, Charisma, Van der Voort van Zyp, Jochem R., Lagendijk, Jan J. W., Grobbee, Diederick E., Verkooijen, Helena M., Moors, Ellen H. M., Innovation and Sustainability, Innovation Studies, Innovation and Sustainability, and Innovation Studies

Subjects
0301 basic medicine, Cancer Research, medicine.medical_specialty, Staffing, lcsh:RC254-282, cancer care, Health administration, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, medicine, Medical physics, implementation, Empirical evidence, Routine care, Original Research, MR-Linac, Abandonment (legal), Professional development, image-guided radiotherapy, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, prostate cancer, medicine.disease, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, MRI-guided radiotherapy, healthcare management, Business, qualitative research, Qualitative research
Abstract

The new radiotherapy high field, 1.5 Tesla MRI-guided linear accelerator (MR-Linac) is being clinically introduced. Sensing and evaluating opportunities and barriers at an early stage will facilitate its eventual scale-up. This study investigates the opportunities and barriers to the implementation of MR-Linac into prostate cancer care based on 43 semi-structured interviews with Dutch oncology care professionals, hospital and division directors, patients, payers and industry. The analysis was guided by the Non-adoption, Abandonment, Scale-up, Spread, and Sustainability framework of new medical technologies and services. Opportunities included: the acquirement of (1) advanced MRI-guided radiotherapy technology with (2) the potential for improved patient outcomes and (3) economic benefits, as well as (4) professional development and (5) a higher hospital quality profile. Barriers included: (1) technical complexities, (2) substantial staffing and structural investments, (3) the current lack of empirical evidence of clinical benefits, (4) professional silos, and (5) the presence of patient referral patterns. While our study confirms the expected technical and clinical prospects from the literature, it also reveals economic, organizational, and socio-political challenges.

Published
2020
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206. Coronary artery calcium scoring: can we do better?

Author

van Velzen, Sanne G. M., de Vos, Bob D., Verkooijen, Helena M., Leiner, Tim, Viergever, Max A., Išgum, Ivana, Isgum, Ivana, Landman, Bennett A., Biomedical Engineering and Physics, Radiology and Nuclear Medicine, ACS - Atherosclerosis & ischemic syndromes, Amsterdam Neuroscience - Brain Imaging, and ACS - Heart failure & arrhythmias

Subjects
Reproducibility, endocrine system diseases, business.industry, Partial volume, nutritional and metabolic diseases, Thresholding, Intensity (physics), Coronary arteries, medicine.anatomical_structure, Calcium scoring, Coronary artery calcification, cardiovascular system, medicine, population characteristics, cardiovascular diseases, business, Nuclear medicine, Artery
Abstract

Coronary artery calcification (CAC) is a strong and independent predictor of cardiovascular disease (CVD) that can be quantified in CT scans showing the heart. CAC lesions are defined as lesions in the coronary arteries with image intensity above 130 HU. The use of a threshold may lead to under- or over-estimation of the amount of CAC and, hence, to incorrect cardiovascular categorization of patients. This is especially pronounced in CT scans without ECG-synchronization where lesions are more subject to cardiac motion and partial volume effects. To address this, we propose a method for quantification of CAC without a threshold. A set of 373 cardiac and 1181 chest CT scans was included to develop the method and a set of 21 scan-rescan pairs (42 scans) was included for final evaluation. Assuming that the attenuation of CAC is superimposed on the attenuation of the artery, we aimed to separate the CAC from the coronary arteries by employing a CycleGAN to generate a synthetic image without CAC from an image containing CAC and vice versa. By subtracting the synthetic image without CAC from the image with CAC, a CAC map is created. The CAC-map can subsequently be used to identify and quantify CAC. The ground truth, i.e. the true amount of CAC, can not be established, therefore, in this work the results generated by the method are compared with clinical calcium scoring in terms of reproducibility. The average relative difference between the calcium scores in scan-rescan pairs of scans was 50% with the proposed method and 86% for the conventional method. Moreover, the correlation between CAC pseudo masses in scan-rescan pairs was 0.92 with the proposed method and 0.89 with conventional calcium scoring. Our proposed method is able to identify and quantify CAC lesions in CT scans without using an intensity level thresholding. This might allow for more reproducible quantification of CAC in CT scans made without ECG synchronization, and, therefore, it might allow more accurate CVD risk prediction.

Published
2020
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207. 177Lu-PSMA for advanced prostate cancer: are we ready to play big?

Author

Hehakaya, Charisma, Moors, Ellen H. M., Verkooijen, Helena M., Grobbee, Diederick E., Verburg, Frederik A., Lam, Marnix G. E. H., Hehakaya, Charisma, Moors, Ellen H. M., Verkooijen, Helena M., Grobbee, Diederick E., Verburg, Frederik A., and Lam, Marnix G. E. H.

Published
2021

208. Reliability and Agreement of Radiological and Pathological Tumor Size in Patients with Multiple Endocrine Neoplasia Type 1-Related Pancreatic Neuroendocrine Tumors: Results from a Population-Based Cohort

Author

Beek, D.J. van, Verkooijen, Helena M., Nell, Sjoerd, Bonsing, B.A., Eijck, C.H. van, Goor, H. van, Brosens, L.A.A., Valk, Gerlof D., Vriens, M.R., Beek, D.J. van, Verkooijen, Helena M., Nell, Sjoerd, Bonsing, B.A., Eijck, C.H. van, Goor, H. van, Brosens, L.A.A., Valk, Gerlof D., and Vriens, M.R.

Abstract

Item does not contain fulltext

Published
2021

209. The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care

Author

Derksen, Jeroen W.G., Vink, Geraldine R., Elferink, Marloes A.G., Roodhart, Jeanine M.L., Verkooijen, Helena M., Grevenstein, Wilhelmina M.U. van, Siersema, P.D., Wilt, J.H.W. de, May, Anne M., Koopman, Miriam, Derksen, Jeroen W.G., Vink, Geraldine R., Elferink, Marloes A.G., Roodhart, Jeanine M.L., Verkooijen, Helena M., Grevenstein, Wilhelmina M.U. van, Siersema, P.D., Wilt, J.H.W. de, May, Anne M., and Koopman, Miriam

Abstract

Contains fulltext : 235069.pdf (Publisher’s version ) (Open Access)

Published
2021

210. 177Lu-PSMA for advanced prostate cancer: are we ready to play big?

Author

Innovation and Sustainability, Innovation Studies, Hehakaya, Charisma, Moors, Ellen H. M., Verkooijen, Helena M., Grobbee, Diederick E., Verburg, Frederik A., Lam, Marnix G. E. H., Innovation and Sustainability, Innovation Studies, Hehakaya, Charisma, Moors, Ellen H. M., Verkooijen, Helena M., Grobbee, Diederick E., Verburg, Frederik A., and Lam, Marnix G. E. H.

Published
2021

211. Colorectal cancer care and patients’ perceptions before and during COVID-19: implications for subsequent SARS-CoV-2 infection waves

Author

Derksen, Jeroen W G, May, Anne M, van de Poll-Franse, Lonneke V, De Rooij, Belle H, Hafkenscheid, Dorothee A, Verkooijen, Helena M, Koopman, Miriam, Vink, Geraldine R, Derksen, Jeroen W G, May, Anne M, van de Poll-Franse, Lonneke V, De Rooij, Belle H, Hafkenscheid, Dorothee A, Verkooijen, Helena M, Koopman, Miriam, and Vink, Geraldine R

Abstract

Background Changes in colorectal cancer (CRC) care planning because of the coronavirus disease 2019 (COVID-19) pandemic and associated health-related quality of life (HRQoL) and well-being of patients with CRC are unknown. We report changes in CRC care and patient-reported outcomes including HRQoL, distress, and loneliness during the first wave of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods In April 2020, 4984 patients included in the nationwide Prospective Dutch Colorectal Cancer cohort were invited to complete a COVID-19–specific questionnaire, together with the validated European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (QLQ-C30), De Jong Gierveld, and Hospital Anxiety and Depression Scale. Clinical data were obtained from the Netherlands Cancer Registry. Scores were compared with the year prior to COVID-19 and with an age- and sex-matched control population during COVID-19. Results In total, 3247 (65.1%) patients responded between April and June 2020. Of the patients, 17% had canceled, postponed, or changed hospital visits to a telephone or video consult, and 5.3% had adjusted, postponed, or canceled treatment. Compared with controls, patients reported worse HRQoL but comparable distress and less social loneliness (patients = 21.2%; controls = 32.9%). Compared with pre–COVID-19, clinically meaningful deterioration of HRQoL was more prevalent in patients with changes in cancer care planning than in patients without changes. Prior to undergoing or currently undergoing treatment and infection worries were associated with lower HRQoL. Conclusions CRC patients reported equal anxiety and depression but worse HRQoL than the control population. Changes in care planning were associated with deterioration of HRQoL and increased anxiety. In case of 1 or more risk factors, health-care specialists should discuss (mental) health status and possible support during f

Published
2021

212. Prognosis after surgery for multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors:Functionality matters

Author

van Beek, Dirk Jan, Nell, Sjoerd, Verkooijen, Helena M., Borel Rinkes, Inne H.M., Valk, Gerlof D., Vriens, Menno R., van Beek, Dirk Jan, Nell, Sjoerd, Verkooijen, Helena M., Borel Rinkes, Inne H.M., Valk, Gerlof D., and Vriens, Menno R.

Abstract

Background: Metastasized pancreatic neuroendocrine tumors are the leading cause of death in patients with multiple endocrine neoplasia type 1. Aside from tumor size, prognostic factors of pancreatic neuroendocrine tumors are largely unknown. The present study aimed to assess whether the prognosis of patients with resected multiple endocrine neoplasia type 1-related nonfunctioning pancreatic neuroendocrine tumors differs from those with resected multiple endocrine neoplasia type 1-related insulinomas and assessed factors associated with prognosis. Methods: Patients who underwent resection of a multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors between 1990 and 2016 were identified in 2 databases: the DutchMEN Study Group and the International MEN1 Insulinoma Study Group databases. Cox regression was performed to compare liver metastases-free survival of patients with a nonfunctioning pancreatic neuroendocrine tumors versus those with an insulinoma and to identify factors associated with liver metastases-free survival. Results: Out of 153 patients with multiple endocrine neoplasia type 1, 61 underwent resection for a nonfunctioning pancreatic neuroendocrine tumor and 92 for an insulinoma. Of the patients with resected lymph nodes, 56% (18/32) of nonfunctioning pancreatic neuroendocrine tumors had lymph node metastases compared to 10% (4/41) of insulinomas (P =.001). Estimated 10-year liver metastases-free survival was 63% (95% confidence interval 42%–76%) for nonfunctioning pancreatic neuroendocrine tumors and 87% (72%–91%) for insulinomas. After adjustment for size, World Health Organization tumor grade, and age, nonfunctioning pancreatic neuroendocrine tumors had an increased risk for liver metastases or death (hazard ratio 3.04 [1.47–6.30]). In pancreatic neuroendocrine tumors ≥2 cm, nonfunctioning pancreatic neuroendocrine tumors (2.99 [1.22–7.33]) and World Health Organization grade 2 (2.95 [1.02–8.50]) were associated with liver meta

Published
2021

213. Reliability and Agreement of Radiological and Pathological Tumor Size in Patients with Multiple Endocrine Neoplasia Type 1-Related Pancreatic Neuroendocrine Tumors:Results from a Population-Based Cohort

Author

Van Beek, Dirk Jan, Verkooijen, Helena M., Nell, Sjoerd, Bonsing, Bert A., Van Eijck, Casper H., Van Goor, Harry, Hoogwater, Frederik J.H., Nieveen Van Dijkum, Elisabeth J.M., Kazemier, Geert, Dejong, Cornelis H.C., Brosens, Lodewijk A.A., Wessels, Frank J., Borel Rinkes, Inne H.M., Valk, Gerlof D., Vriens, Menno R., Van Beek, Dirk Jan, Verkooijen, Helena M., Nell, Sjoerd, Bonsing, Bert A., Van Eijck, Casper H., Van Goor, Harry, Hoogwater, Frederik J.H., Nieveen Van Dijkum, Elisabeth J.M., Kazemier, Geert, Dejong, Cornelis H.C., Brosens, Lodewijk A.A., Wessels, Frank J., Borel Rinkes, Inne H.M., Valk, Gerlof D., and Vriens, Menno R.

Abstract

Background: Pancreatic neuroendocrine tumors (pNETs) have a high prevalence in patients with multiple endocrine neoplasia type 1 (MEN1) and are the leading cause of death. Tumor size is still regarded as the main prognostic factor and therefore used for surgical decision-making. We assessed reliability and agreement of radiological and pathological tumor size in a population-based cohort of patients with MEN1-related pNETs. Methods: Patients were selected from the Dutch MEN1 database if they had undergone a resection for a pNET between 2003 and 2018. Radiological (MRI, CT, and endoscopic ultrasonography [EUS]) and pathological tumor size were collected from patient records. Measures of agreement (Bland-Altman plots with limits of agreement [LoA] and absolute agreement) and reliability (intraclass correlation coefficients [ICC] and unweighted kappa) were calculated for continuous and categorized (< or ≥2 cm) pNET size. Results: In 73 included patients, the median radiological and pathological tumor sizes measured were 22 (3-160) and 21 (4-200) mm, respectively. Mean bias between radiological and pathological tumor size was -0.2 mm and LoA ranged from -12.9 to 12.6 mm. For the subgroups of MRI, CT, and EUS, LoA of radiological and pathological tumor size ranged from -9.6 to 10.9, -15.9 to 15.8, and -13.9 to 11.0, respectively. ICCs for the overall cohort, MRI, CT, and EUS were 0.80, 0.86, 0.75, and 0.76, respectively. Based on the 2 cm criterion, agreement was 81.5%; hence, 12 patients (18.5%) were classified differently between imaging and pathology. Absolute agreement and kappa values of MRI, CT, and EUS were 88.6, 85.7, and 75.0%, and 0.77, 0.71, and 0.50, respectively. Conclusion: Within a population-based cohort, MEN1-related pNET size was not systematically over- or underestimated on preoperative imaging. Based on agreement and reliability measures, MRI is the preferred imaging modality.

Published
2021

214. Coronary artery calcifications on breast cancer radiotherapy planning CT scans and cardiovascular risk: What do patients want to know?

Author

Trialbureau Beeld, Cancer, Onderzoek Radiotherapie, Epi Kanker Team A, Brain, MS Radiotherapie, Beeldverwerking ISI, Gal, Roxanne, Gregorowitsch, Madelijn L., Emaus, Marleen J., Blezer, Erwin LA, van der Leij, Femke, van Velzen, Sanne GM, van Tol-Geerdink, Julia J., Išgum, Ivana, Verkooijen, Helena M., Trialbureau Beeld, Cancer, Onderzoek Radiotherapie, Epi Kanker Team A, Brain, MS Radiotherapie, Beeldverwerking ISI, Gal, Roxanne, Gregorowitsch, Madelijn L., Emaus, Marleen J., Blezer, Erwin LA, van der Leij, Femke, van Velzen, Sanne GM, van Tol-Geerdink, Julia J., Išgum, Ivana, and Verkooijen, Helena M.

Published
2021

215. Expectations of treatment outcomes in patients with spinal metastases; what do we tell our patients?: A qualitative study

Author

Trialbureau Beeld, Other research (not in main researchprogram), Cancer, MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Versteeg, Anne L, Gal, Roxanne, Charest-Morin, Raphaele, Verlaan, Jorrit-Jan, Wessels, Hester, Fisher, Charles G, Verkooijen, Helena M, Trialbureau Beeld, Other research (not in main researchprogram), Cancer, MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Versteeg, Anne L, Gal, Roxanne, Charest-Morin, Raphaele, Verlaan, Jorrit-Jan, Wessels, Hester, Fisher, Charles G, and Verkooijen, Helena M

Published
2021

216. Adaptive magnetic resonance-guided neurovascular-sparing radiotherapy for preservation of erectile function in prostate cancer patients

Author

Cancer, Onderzoek Radiotherapie, Urologie Onderzoek, Trialbureau Beeld, MS Radiotherapie, Teunissen, Frederik R, Wortel, Ruud C, Hes, Jochem, Willigenburg, Thomas, de Groot-van Breugel, Eline N, de Boer, Johannes C J, van Melick, Harm H E, Verkooijen, Helena M, van der Voort van Zyp, Jochem R N, Cancer, Onderzoek Radiotherapie, Urologie Onderzoek, Trialbureau Beeld, MS Radiotherapie, Teunissen, Frederik R, Wortel, Ruud C, Hes, Jochem, Willigenburg, Thomas, de Groot-van Breugel, Eline N, de Boer, Johannes C J, van Melick, Harm H E, Verkooijen, Helena M, and van der Voort van Zyp, Jochem R N

Published
2021

217. Methods and results used in the development of a consensus-driven extension to the Consolidated Standards of Reporting Trials (CONSORT) statement for trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE)

Author

Trialbureau Beeld, Cancer, JC onderzoeksprogramma Kanker, Imran, Mahrukh, Kwakkenbos, Linda, McCall, Stephen J, McCord, Kimberly A, Fröbert, Ole, Hemkens, Lars G, Zwarenstein, Merrick, Relton, Clare, Rice, Danielle B, Langan, Sinéad M, Benchimol, Eric I, Thabane, Lehana, Campbell, Marion K, Sampson, Margaret, Erlinge, David, Verkooijen, Helena M, Moher, David, Boutron, Isabelle, Ravaud, Philippe, Nicholl, Jon, Uher, Rudolf, Sauvé, Maureen, Fletcher, John, Torgerson, David, Gale, Chris, Juszczak, Edmund, Thombs, Brett D, Trialbureau Beeld, Cancer, JC onderzoeksprogramma Kanker, Imran, Mahrukh, Kwakkenbos, Linda, McCall, Stephen J, McCord, Kimberly A, Fröbert, Ole, Hemkens, Lars G, Zwarenstein, Merrick, Relton, Clare, Rice, Danielle B, Langan, Sinéad M, Benchimol, Eric I, Thabane, Lehana, Campbell, Marion K, Sampson, Margaret, Erlinge, David, Verkooijen, Helena M, Moher, David, Boutron, Isabelle, Ravaud, Philippe, Nicholl, Jon, Uher, Rudolf, Sauvé, Maureen, Fletcher, John, Torgerson, David, Gale, Chris, Juszczak, Edmund, and Thombs, Brett D

Published
2021

218. Health-related quality of life of early-stage breast cancer patients after different radiotherapy regimens

Author

Onderzoek Radiotherapie, Trialbureau Beeld, Cancer, JC onderzoeksprogramma Kanker, Jacobs, Daphne H M, Charaghvandi, Ramona, Horeweg, Nanda, Maduro, John H, Speijer, Gabrielle, Roeloffzen, Ellen M A, Mast, Mirjam, Bantema-Joppe, Enja, Petoukhova, Anna L, van den Bongard, Desirée H J G, Koper, Peter, Crijns, Anne P G, Marijnen, Corrie A M, Verkooijen, Helena M, Onderzoek Radiotherapie, Trialbureau Beeld, Cancer, JC onderzoeksprogramma Kanker, Jacobs, Daphne H M, Charaghvandi, Ramona, Horeweg, Nanda, Maduro, John H, Speijer, Gabrielle, Roeloffzen, Ellen M A, Mast, Mirjam, Bantema-Joppe, Enja, Petoukhova, Anna L, van den Bongard, Desirée H J G, Koper, Peter, Crijns, Anne P G, Marijnen, Corrie A M, and Verkooijen, Helena M

Published
2021

220. The impact of hyperbaric oxygen therapy on late radiation toxicity and quality of life in breast cancer patients

Author

Trialbureau Beeld, Cancer, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), MS Radiotherapie, MS Medische Oncologie, JC onderzoeksprogramma Kanker, Batenburg, Marilot C. T., Maarse, Wies, van der Leij, Femke, Baas, Inge O., Boonstra, Onno, Lansdorp, Nina, Doeksen, Annemiek, van den Bongard, HJGD, Verkooijen, Helena M., Trialbureau Beeld, Cancer, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), MS Radiotherapie, MS Medische Oncologie, JC onderzoeksprogramma Kanker, Batenburg, Marilot C. T., Maarse, Wies, van der Leij, Femke, Baas, Inge O., Boonstra, Onno, Lansdorp, Nina, Doeksen, Annemiek, van den Bongard, HJGD, and Verkooijen, Helena M.

Published
2021

221. Dancing With Health: Quality of Life and Physical Improvements From an EU Collaborative Dance Programme With Women Following Breast Cancer Treatment

Author

Trialbureau Beeld, Cancer, JC onderzoeksprogramma Kanker, Karkou, Vicky, Dudley-Swarbrick, Irene, Starkey, Jennifer, Parsons, Ailsa, Aithal, Supritha, Omylinska-Thurston, Joanna, Verkooijen, Helena M, van den Boogaard, Rosalie, Dochevska, Yoanna, Djobova, Stefka, Zdravkov, Ivaylo, Dimitrova, Ivelina, Moceviciene, Aldona, Bonifacino, Adriana, Asumi, Alexis Matua, Forgione, Dolores, Ferrari, Andrea, Grazioli, Elisa, Cerulli, Claudia, Tranchita, Eliana, Sacchetti, Massimo, Parisi, Attilio, Trialbureau Beeld, Cancer, JC onderzoeksprogramma Kanker, Karkou, Vicky, Dudley-Swarbrick, Irene, Starkey, Jennifer, Parsons, Ailsa, Aithal, Supritha, Omylinska-Thurston, Joanna, Verkooijen, Helena M, van den Boogaard, Rosalie, Dochevska, Yoanna, Djobova, Stefka, Zdravkov, Ivaylo, Dimitrova, Ivelina, Moceviciene, Aldona, Bonifacino, Adriana, Asumi, Alexis Matua, Forgione, Dolores, Ferrari, Andrea, Grazioli, Elisa, Cerulli, Claudia, Tranchita, Eliana, Sacchetti, Massimo, and Parisi, Attilio

Published
2021

222. CONSORT extension for the reporting of randomised controlled trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE): checklist with explanation and elaboration

Author

Trialbureau Beeld, Cancer, JC onderzoeksprogramma Kanker, Kwakkenbos, Linda, Imran, Mahrukh, McCall, Stephen J, McCord, Kimberly A, Fröbert, Ole, Hemkens, Lars G, Zwarenstein, Merrick, Relton, Clare, Rice, Danielle B, Langan, Sinéad M, Benchimol, Eric I, Thabane, Lehana, Campbell, Marion K, Sampson, Margaret, Erlinge, David, Verkooijen, Helena M, Moher, David, Boutron, Isabelle, Ravaud, Philippe, Nicholl, Jon, Uher, Rudolf, Sauvé, Maureen, Fletcher, John, Torgerson, David, Gale, Chris, Juszczak, Edmund, Thombs, Brett D, Trialbureau Beeld, Cancer, JC onderzoeksprogramma Kanker, Kwakkenbos, Linda, Imran, Mahrukh, McCall, Stephen J, McCord, Kimberly A, Fröbert, Ole, Hemkens, Lars G, Zwarenstein, Merrick, Relton, Clare, Rice, Danielle B, Langan, Sinéad M, Benchimol, Eric I, Thabane, Lehana, Campbell, Marion K, Sampson, Margaret, Erlinge, David, Verkooijen, Helena M, Moher, David, Boutron, Isabelle, Ravaud, Philippe, Nicholl, Jon, Uher, Rudolf, Sauvé, Maureen, Fletcher, John, Torgerson, David, Gale, Chris, Juszczak, Edmund, and Thombs, Brett D

Published
2021

223. Colorectal Cancer Care and Patients' Perceptions Before and During COVID-19: Implications for Subsequent SARS-CoV-2 Infection Waves

Author

Epi Kanker Team B, Cancer, Epidemiology & Health Economics, JC onderzoeksprogramma Kanker, Trialbureau Beeld, MS Medische Oncologie, Onderzoek Medische Oncologie, Derksen, Jeroen W G, May, Anne M, van de Poll-Franse, Lonneke V, de Rooij, Belle H, Hafkenscheid, Dorothee A, Verkooijen, Helena M, Koopman, Miriam, Vink, Geraldine R, Epi Kanker Team B, Cancer, Epidemiology & Health Economics, JC onderzoeksprogramma Kanker, Trialbureau Beeld, MS Medische Oncologie, Onderzoek Medische Oncologie, Derksen, Jeroen W G, May, Anne M, van de Poll-Franse, Lonneke V, de Rooij, Belle H, Hafkenscheid, Dorothee A, Verkooijen, Helena M, Koopman, Miriam, and Vink, Geraldine R

Published
2021

224. Effects of exercise in breast cancer patients: implications of the trials within cohorts (TwiCs) design in the UMBRELLA Fit trial

Author

Trialbureau Beeld, Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team A, Epi Methoden Team 1, MS Radiotherapie, Epidemiology & Health Economics, Gal, Roxanne, Monninkhof, Evelyn M, van Gils, Carla H, Groenwold, Rolf H H, Elias, Sjoerd G, van den Bongard, Desirée H J G, Peeters, Petra H M, Verkooijen, Helena M, May, Anne M, Trialbureau Beeld, Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team A, Epi Methoden Team 1, MS Radiotherapie, Epidemiology & Health Economics, Gal, Roxanne, Monninkhof, Evelyn M, van Gils, Carla H, Groenwold, Rolf H H, Elias, Sjoerd G, van den Bongard, Desirée H J G, Peeters, Petra H M, Verkooijen, Helena M, and May, Anne M

Published
2021

225. Anorectal dose–effect relations for late gastrointestinal toxicity following external beam radiotherapy for prostate cancer in the FLAME trial

Author

Trialbureau Beeld, Cancer, Biostatistiek Onderzoek, Other research (not in main researchprogram), MS Radiotherapie, Epi Kanker Team C, JC onderzoeksprogramma Kanker, Klinische Fysica RT, Divisie Beeld, Groen, Veerle H., Zuithoff, Nicolaas P.A., van Schie, Marcel, Monninkhof, Evelyn M., Kunze-Busch, Martina, de Boer, Hans C.J., van der Voort van Zyp, Jochem, Pos, Floris J., Smeenk, Robert Jan, Haustermans, Karin, Isebaert, Sofie, Draulans, Cédric, Depuydt, Tom, Verkooijen, Helena M., van der Heide, Uulke A., Kerkmeijer, Linda G.W., Trialbureau Beeld, Cancer, Biostatistiek Onderzoek, Other research (not in main researchprogram), MS Radiotherapie, Epi Kanker Team C, JC onderzoeksprogramma Kanker, Klinische Fysica RT, Divisie Beeld, Groen, Veerle H., Zuithoff, Nicolaas P.A., van Schie, Marcel, Monninkhof, Evelyn M., Kunze-Busch, Martina, de Boer, Hans C.J., van der Voort van Zyp, Jochem, Pos, Floris J., Smeenk, Robert Jan, Haustermans, Karin, Isebaert, Sofie, Draulans, Cédric, Depuydt, Tom, Verkooijen, Helena M., van der Heide, Uulke A., and Kerkmeijer, Linda G.W.

Published
2021

226. In Reply to Tsoutsou

Author

Trialbureau Beeld, Pathologie Pathologen staf, Cancer, Pathologie Algemene Pat.zorg, Pathologie Groep Van Diest, Onderzoek Radiotherapie, Pathologie, JC onderzoeksprogramma Kanker, Vasmel, Jeanine E., Vreuls, Celien P.H., Manson, Quirine F., Charaghvandi, Ramona K., van Gorp, Joost, van Leeuwen, A. M.Gijs, van Diest, Paul J., Verkooijen, Helena M., Desiree van den Bongard, H. J.G., Trialbureau Beeld, Pathologie Pathologen staf, Cancer, Pathologie Algemene Pat.zorg, Pathologie Groep Van Diest, Onderzoek Radiotherapie, Pathologie, JC onderzoeksprogramma Kanker, Vasmel, Jeanine E., Vreuls, Celien P.H., Manson, Quirine F., Charaghvandi, Ramona K., van Gorp, Joost, van Leeuwen, A. M.Gijs, van Diest, Paul J., Verkooijen, Helena M., and Desiree van den Bongard, H. J.G.

Published
2021

227. Identification of Risk of Cardiovascular Disease by Automatic Quantification of Coronary Artery Calcifications on Radiotherapy Planning CT Scans in Patients with Breast Cancer

Author

Trialbureau Beeld, Cancer, JC onderzoeksprogramma Kanker, Beeldverwerking ISI, Epi Kanker Team A, MS Radiotherapie, Onderzoek Radiotherapie, Brain, Researchgr. Cardiovasculaire Radiologie, Circulatory Health, MS Radiologie, Researchgr. Systems Radiology, Infection & Immunity, Regenerative Medicine and Stem Cells, Researchbureau DHL, Team Medisch, Datamanagement 1, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Gal, Roxanne, Van Velzen, Sanne G.M., Hooning, Maartje J., Emaus, Marleen J., Van Der Leij, Femke, Gregorowitsch, Madelijn L., Blezer, Erwin L.A., Gernaat, Sofie A.M., Lessmann, Nikolas, Sattler, Margriet G.A., Leiner, Tim, De Jong, Pim A., Teske, Arco J., Verloop, Janneke, Penninkhof, Joan J., Vaartjes, Ilonca, Meijer, Hanneke, Van Tol-Geerdink, Julia J., Pignol, Jean Philippe, Van Den Bongard, Desirée H.J.G., Išgum, Ivana, Verkooijen, Helena M., Trialbureau Beeld, Cancer, JC onderzoeksprogramma Kanker, Beeldverwerking ISI, Epi Kanker Team A, MS Radiotherapie, Onderzoek Radiotherapie, Brain, Researchgr. Cardiovasculaire Radiologie, Circulatory Health, MS Radiologie, Researchgr. Systems Radiology, Infection & Immunity, Regenerative Medicine and Stem Cells, Researchbureau DHL, Team Medisch, Datamanagement 1, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Gal, Roxanne, Van Velzen, Sanne G.M., Hooning, Maartje J., Emaus, Marleen J., Van Der Leij, Femke, Gregorowitsch, Madelijn L., Blezer, Erwin L.A., Gernaat, Sofie A.M., Lessmann, Nikolas, Sattler, Margriet G.A., Leiner, Tim, De Jong, Pim A., Teske, Arco J., Verloop, Janneke, Penninkhof, Joan J., Vaartjes, Ilonca, Meijer, Hanneke, Van Tol-Geerdink, Julia J., Pignol, Jean Philippe, Van Den Bongard, Desirée H.J.G., Išgum, Ivana, and Verkooijen, Helena M.

Published
2021

228. Combining radiotherapy and focused ultrasound for pain palliation of cancer induced bone pain; a stage I/IIa study according to the IDEAL framework

Author

Trialbureau Beeld, Cancer, Researchgr. Beeldg. Moleculaire Interv., Beeldverwerking ISI, MS Radiotherapie, MS Radiologie, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Kanker, Bartels, Marcia M T J, Verpalen, Inez M, Ferrer, Cyril J, Slotman, Derk J, Phernambucq, Erik C J, Verhoeff, Joost J C, Eppinga, Wietse S C, Braat, Manon N G J A, van den Hoed, Rolf D, van 't Veer-Ten Kate, Miranda, de Boer, Erwin, Naber, Harry R, Nijholt, Ingrid M, Bartels, Lambertus W, Bos, Clemens, Moonen, Chrit T W, Boomsma, Martijn F, Verkooijen, Helena M, Trialbureau Beeld, Cancer, Researchgr. Beeldg. Moleculaire Interv., Beeldverwerking ISI, MS Radiotherapie, MS Radiologie, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Kanker, Bartels, Marcia M T J, Verpalen, Inez M, Ferrer, Cyril J, Slotman, Derk J, Phernambucq, Erik C J, Verhoeff, Joost J C, Eppinga, Wietse S C, Braat, Manon N G J A, van den Hoed, Rolf D, van 't Veer-Ten Kate, Miranda, de Boer, Erwin, Naber, Harry R, Nijholt, Ingrid M, Bartels, Lambertus W, Bos, Clemens, Moonen, Chrit T W, Boomsma, Martijn F, and Verkooijen, Helena M

Published
2021

229. Impact of the COVID-19 Pandemic on Patient-Reported Outcomes of Breast Cancer Patients and Survivors

Author

Trialbureau Beeld, Cancer, MS Radiotherapie, MS Medische Oncologie, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), MS CGO, Onderzoek Radiotherapie, JC onderzoeksprogramma Kanker, Bargon, Claudia A, Batenburg, Marilot C T, van Stam, Lilianne E, Mink van der Molen, Dieuwke R, van Dam, Iris E, van der Leij, Femke, Baas, Inge O, Ernst, Miranda F, Maarse, Wiesje, Vermulst, Nieke, Schoenmaeckers, Ernst J P, van Dalen, Thijs, Bijlsma, Rhodé M, Young-Afat, Danny A, Doeksen, Annemiek, Verkooijen, Helena M, Trialbureau Beeld, Cancer, MS Radiotherapie, MS Medische Oncologie, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), MS CGO, Onderzoek Radiotherapie, JC onderzoeksprogramma Kanker, Bargon, Claudia A, Batenburg, Marilot C T, van Stam, Lilianne E, Mink van der Molen, Dieuwke R, van Dam, Iris E, van der Leij, Femke, Baas, Inge O, Ernst, Miranda F, Maarse, Wiesje, Vermulst, Nieke, Schoenmaeckers, Ernst J P, van Dalen, Thijs, Bijlsma, Rhodé M, Young-Afat, Danny A, Doeksen, Annemiek, and Verkooijen, Helena M

Published
2021

230. Oncology patients were found to understand and accept the Trials within Cohorts design

Author

Onderzoek Radiotherapie, Trialbureau Beeld, Cancer, JC onderzoeksprogramma Kanker, Arts-assistenten Radiotherapie, MS Radiotherapie, Epidemiology & Health Economics, Bioethics & Health Humanities, JC onderzoeksprogramma Methodologie, Circulatory Health, Medical Humanities Onderzoek Team 1, Epi Kanker Team A, Young-Afat, Danny A., Gal, Roxanne, Gerlich, Sophie, Burbach, Johannes P.M., van der Velden, Joanne M., van den Bongard, Desireé H.J.G., Intven, Martijn P.W., Kasperts, Nicolien, May, Anne M., van der Graaf, Rieke, van Gils, Carla H., Verkooijen, Helena M., Onderzoek Radiotherapie, Trialbureau Beeld, Cancer, JC onderzoeksprogramma Kanker, Arts-assistenten Radiotherapie, MS Radiotherapie, Epidemiology & Health Economics, Bioethics & Health Humanities, JC onderzoeksprogramma Methodologie, Circulatory Health, Medical Humanities Onderzoek Team 1, Epi Kanker Team A, Young-Afat, Danny A., Gal, Roxanne, Gerlich, Sophie, Burbach, Johannes P.M., van der Velden, Joanne M., van den Bongard, Desireé H.J.G., Intven, Martijn P.W., Kasperts, Nicolien, May, Anne M., van der Graaf, Rieke, van Gils, Carla H., and Verkooijen, Helena M.

Published
2021

231. Tumor-Infiltrating Lymphocytes in Low-Risk Patients With Breast Cancer Treated With Single-Dose Preoperative Partial Breast Irradiation

Author

Trialbureau Beeld, Pathologie Pathologen staf, Cancer, Pathologie Groep Van Diest, Pathologie, JC onderzoeksprogramma Kanker, Vasmel, Jeanine E, Vreuls, Celien Ph, Manson, Quirine F, Charaghvandi, Ramona K, van Gorp, Joost, van Leeuwen, Am Gijs, van Diest, Paul J, Verkooijen, Helena M, Desiree van den Bongard, H J G, Trialbureau Beeld, Pathologie Pathologen staf, Cancer, Pathologie Groep Van Diest, Pathologie, JC onderzoeksprogramma Kanker, Vasmel, Jeanine E, Vreuls, Celien Ph, Manson, Quirine F, Charaghvandi, Ramona K, van Gorp, Joost, van Leeuwen, Am Gijs, van Diest, Paul J, Verkooijen, Helena M, and Desiree van den Bongard, H J G

Published
2021

232. 177Lu-PSMA for advanced prostate cancer: are we ready to play big?

Author

Cancer, Trialbureau Beeld, JC onderzoeksprogramma Kanker, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Researchgr. Nucleaire Geneeskunde, Hehakaya, Charisma, Moors, Ellen H M, Verkooijen, Helena M, Grobbee, Diederick E, Verburg, Frederik A, Lam, Marnix G E H, Cancer, Trialbureau Beeld, JC onderzoeksprogramma Kanker, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Researchgr. Nucleaire Geneeskunde, Hehakaya, Charisma, Moors, Ellen H M, Verkooijen, Helena M, Grobbee, Diederick E, Verburg, Frederik A, and Lam, Marnix G E H

Published
2021

233. Reliability and Agreement of Radiological and Pathological Tumor Size in Patients with Multiple Endocrine Neoplasia Type 1-Related Pancreatic Neuroendocrine Tumors: Results from a Population-Based Cohort

Author

MS CGO, Cancer, Divisie Beeld, Trialbureau Beeld, JC onderzoeksprogramma Kanker, Heelkunde Opleiding, Pathologie Pathologen staf, MS Radiologie, Regenerative Medicine and Stem Cells, MS Endocriene Oncologie, Van Beek, Dirk Jan, Verkooijen, Helena M., Nell, Sjoerd, Bonsing, Bert A., Van Eijck, Casper H., Van Goor, Harry, Hoogwater, Frederik J.H., Nieveen Van Dijkum, Elisabeth J.M., Kazemier, Geert, Dejong, Cornelis H.C., Brosens, Lodewijk A.A., Wessels, Frank J., Borel Rinkes, Inne H.M., Valk, Gerlof D., Vriens, Menno R., MS CGO, Cancer, Divisie Beeld, Trialbureau Beeld, JC onderzoeksprogramma Kanker, Heelkunde Opleiding, Pathologie Pathologen staf, MS Radiologie, Regenerative Medicine and Stem Cells, MS Endocriene Oncologie, Van Beek, Dirk Jan, Verkooijen, Helena M., Nell, Sjoerd, Bonsing, Bert A., Van Eijck, Casper H., Van Goor, Harry, Hoogwater, Frederik J.H., Nieveen Van Dijkum, Elisabeth J.M., Kazemier, Geert, Dejong, Cornelis H.C., Brosens, Lodewijk A.A., Wessels, Frank J., Borel Rinkes, Inne H.M., Valk, Gerlof D., and Vriens, Menno R.

Published
2021

235. CONSORT extension for the reporting of randomised controlled trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE): checklist with explanation and elaboration

Author

Kwakkenbos, Linda, primary, Imran, Mahrukh, additional, McCall, Stephen J, additional, McCord, Kimberly A, additional, Fröbert, Ole, additional, Hemkens, Lars G, additional, Zwarenstein, Merrick, additional, Relton, Clare, additional, Rice, Danielle B, additional, Langan, Sinéad M, additional, Benchimol, Eric I, additional, Thabane, Lehana, additional, Campbell, Marion K, additional, Sampson, Margaret, additional, Erlinge, David, additional, Verkooijen, Helena M, additional, Moher, David, additional, Boutron, Isabelle, additional, Ravaud, Philippe, additional, Nicholl, Jon, additional, Uher, Rudolf, additional, Sauvé, Maureen, additional, Fletcher, John, additional, Torgerson, David, additional, Gale, Chris, additional, Juszczak, Edmund, additional, and Thombs, Brett D, additional

Published
2021
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236. Tumor-Infiltrating Lymphocytes in Low-Risk Patients With Breast Cancer Treated With Single-Dose Preoperative Partial Breast Irradiation

Author

Vasmel, Jeanine E., primary, Vreuls, Celien P.H., additional, Manson, Quirine F., additional, Charaghvandi, Ramona K., additional, van Gorp, Joost, additional, van Leeuwen, A.M. Gijs, additional, van Diest, Paul J., additional, Verkooijen, Helena M., additional, and van den Bongard, H.J.G. Desiree, additional

Published
2021
Full Text
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237. Prognosis after surgery for multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors: Functionality matters

Author

van Beek, Dirk-Jan, primary, Nell, Sjoerd, additional, Verkooijen, Helena M., additional, Borel Rinkes, Inne H.M., additional, Valk, Gerlof D., additional, Vriens, Menno R., additional, Goudet, Pierre, additional, Santucci, Nicolas, additional, Bartsch, Detlef K., additional, Manoharan, Jerena, additional, Perrier, Nancy D., additional, Zagzag, Jonathan, additional, Brandi, Maria Luisa, additional, Giusti, Francesca, additional, Nilubol, Naris, additional, Brunaud, Laurent, additional, Pasternak, Jesse D., additional, Hsiao, Ralph, additional, Sturgeon, Cord, additional, Giri, Sneha, additional, Conemans, Elfi B., additional, Brosens, Lodewijk A., additional, Bonsing, Bert A., additional, van Eijck, Casper H., additional, van Goor, Harry, additional, de Kleine, Ruben H.J., additional, Nieveen van Dijkum, Elisabeth J., additional, Kazemier, Geert, additional, and Dejong, Cornelis H.C., additional

Published
2021
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239. Abstract S02-02: The impact of resuming the breast cancer screening program in the Netherlands on breast cancer incidence and stage after its discontinuation due to the COVID-19 pandemic

Author

Eijkelboom, Anouk H., primary, de Munck, Linda, additional, Lobbes, Marc B.I., additional, Wesseling, Jelle, additional, van Gils, Carla H., additional, Westenend, Pieter J., additional, Paez, Cristina Guerrero, additional, Pijnappel, Ruud M., additional, Verkooijen, Helena M., additional, Broeders, Mireille J.M., additional, and Siesling, Sabine, additional

Published
2021
Full Text
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244. Dancing With Health: Quality of Life and Physical Improvements From an EU Collaborative Dance Programme With Women Following Breast Cancer Treatment

Author

Karkou, Vicky, primary, Dudley-Swarbrick, Irene, additional, Starkey, Jennifer, additional, Parsons, Ailsa, additional, Aithal, Supritha, additional, Omylinska-Thurston, Joanna, additional, Verkooijen, Helena M., additional, van den Boogaard, Rosalie, additional, Dochevska, Yoanna, additional, Djobova, Stefka, additional, Zdravkov, Ivaylo, additional, Dimitrova, Ivelina, additional, Moceviciene, Aldona, additional, Bonifacino, Adriana, additional, Asumi, Alexis Matua, additional, Forgione, Dolores, additional, Ferrari, Andrea, additional, Grazioli, Elisa, additional, Cerulli, Claudia, additional, Tranchita, Eliana, additional, Sacchetti, Massimo, additional, and Parisi, Attilio, additional

Published
2021
Full Text
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