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1,342 results on '"WANG Lang"'

202. Relationship Between the Expression of PD-1 and CTLA-4 on T Lymphocytes and the Severity and Prognosis of Sepsis

Author

Wang,Lang, Zhang,Zhiqi, Chen,Xingxiang, Yu,Fang, Huang,Hai, Shen,Xue, Tan,Yujie, Wu,Qingqing, Wang,Lang, Zhang,Zhiqi, Chen,Xingxiang, Yu,Fang, Huang,Hai, Shen,Xue, Tan,Yujie, and Wu,Qingqing

Abstract

Lang Wang,1,2,&ast; Zhiqi Zhang,1,3,&ast; Xingxiang Chen,1 Fang Yu,4 Hai Huang,4 Xue Shen,4 Yujie Tan,4 Qingqing Wu4 1Department of Microbiology and Immunology, School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, People’s Republic of China; 2Hunan University of Medicine, Huaihua, People’s Republic of China; 3Taian City Central Hospital Affiliated to Qingdao University, Taian, People’s Republic of China; 4Center of Clinical Laboratory, the Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qingqing Wu, Center of Clinical Laboratory, the Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China, Email wuqingqing@gmc.edu.cnPurpose: The study aimed to investigate the relationship between the expression of PD-1 and CTLA-4 on the surface of peripheral blood T lymphocyte subsets in patients with sepsis and the severity and prognosis of the disease.Patients and Methods: The study included patients with sepsis who were admitted to the intensive care unit. The expression of PD-1 and CTLA-4 on T lymphocyte subsets was detected by flow cytometry, and the severity of sepsis was assessed using the SOFA score.Results: The expression of PD-1 on CD4+T cells, PD-1 on Tregs, and CTLA-4 on Tregs increased with the severity of the disease (P< 0.05). Multivariate logistic regression analysis showed that PD-1 expression on CD4+T cells, CTLA-4 expression on Tregs, and the SOFA score were independent risk factors for 28-day mortality in patients with sepsis (P< 0.05). The area under the curve of the SOFA score combined with the expression of PD-1 on CD4+T cells and CTLA-4 on Treg cells was significantly higher than any single indicator (P< 0.05). Patients with high expression of PD-1 on CD4+T cells (> 31.25%) and CTLA-4 on Tregs (> 12.64%) had a lower 28-day survival rate (P< 0.05).Conclusion: The i

Published
2023

205. Fuse mitochondria to win peer competition.

Author

Wang, Lang and Gu, Yan

Subjects
*MITOCHONDRIAL dynamics, *MITOCHONDRIA, *NEUROPLASTICITY, *NEURONS
Abstract

In this issue of Neuron , Kochan et al. 1 report that enhanced mitochondrial fusion is essential for the heightened synaptic plasticity in adult-born neurons during the critical period, thus supporting their competition with neurons of similar age for survival. In this issue of Neuron , Kochan et al. report that enhanced mitochondrial fusion is essential for the heightened synaptic plasticity in adult-born neurons during the critical period, thus supporting their competition with neurons of similar age for survival. [ABSTRACT FROM AUTHOR]

Published
2024
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237. A Novel Approach to Building an Autonomous System that Enables Predictive Maintenance for Compression Systems

Author

Cao, Gaojing, additional, Wang, Xiangzeng, additional, Kang, Jinlong, additional, Liang, Quansheng, additional, Xie, Yundong, additional, Williams, Paul, additional, Kartoatmodjo, Gayatri, additional, Henson, Richard, additional, Florez, Fabian, additional, Cui, Jining, additional, Fendt, Andrew, additional, Mu, Xiaotao, additional, Wang, Lang, additional, Yang, Wan, additional, Zhang, Bo, additional, He, Jianping, additional, and Zheng, Haibo, additional

Published
2022
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247. Risk factors for post-traumatic stress disorder in acute trauma patients：A protocol for systematic review and meta-analysis

Author

Wang, Lang

Subjects
Medicine and Health Sciences
Abstract

Post-traumatic stress disorder (PTSD) is one of the most commonly reported mental health consequences, followed by disasters and traumatic events, either natural or man-made. At present, there are no unified results for the prevalence rate of PTSD in patients suffering from acute trauma and related influencing factors. Therefore, the purpose of this study is to systematically evaluate the existing literatures, thus obtaining a comprehensive estimation of the combined prevalence rate of PTSD and related factors in trauma patients, so as to provide evidence support for clinical disease prediction models and intervention strategies.

Published
2022
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