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1,726 results on '"Wang, Zefeng"'

204. Coacervate Microdroplets as Synthetic Protocells for Cell Mimicking and Signaling Communications.

Author

Wang, Zefeng, Zhang, Min, Zhou, Yan, Zhang, Yanwen, Wang, Kemin, and Liu, Jianbo

Subjects
*MICRODROPLETS, *SIGNALS & signaling, *CELL communication, *BIOMIMETICS, *TELECOMMUNICATION systems, *BIOMIMETIC materials
Abstract

Synthetic protocells are minimal systems that mimic certain properties of natural cells and are used to research the emergence of life from a nonliving chemical network. Currently, coacervate microdroplets, which are formed via liquid–liquid phase separation, are receiving wide attention in the context of cell biology and protocell research; these microdroplets are notable because they can provide liquid‐like compartment structures for biochemical reactions by creating highly macromolecular crowded local environments. In this review, an overview of recent research on the formation of coacervate microdroplets through phase separation; the design of coacervate‐based stimuli‐responsive protocells, multichamber protocells, and membranized protocells; and their cell mimic behaviors, is provided. The simplified protocell models with precisely defined and tunable compositions advance the understanding of the requirements for cellular structure and function. Efforts are then discussed to establish signal communication systems in protocell and protocell consortia, as communication is a fundamental feature of life that coordinates matter exchanges and energy fluxes dynamically in space and time. Finally, some perspectives on the challenges and future developments of synthetic protocell research in biomimetic science and biomedical applications are provided. [ABSTRACT FROM AUTHOR]

Published
2023
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206. Fabrication of a Counter-Directional Pump/Signal Combiner with Built-In Mode Field Adapter.

Author

Wang, Jiawei, Li, Zhixian, Fu, Min, Tian, Xin, Rao, Binyu, Chen, Zilun, and Wang, Zefeng

Subjects
STIMULATED Raman scattering, PUMPING machinery, RAMAN effect, SIGNALS & signaling, ADAPTERS (Telecommunication)
Abstract

This article introduces a novel counter-directional pump/signal combiner with a built-in mode field adapter. This combiner offers additional functionality to address the problem of mode field mismatch between the gain fiber and delivery fiber, which occurs when using a large-core (50 μm) signal fiber to suppress stimulated Raman scattering. The combiner exhibits negligible degradation in beam quality as a result of implementing mode field matching and employing an effective feedback alignment technique. The beam quality of the mode field adapter integrated in the combiner is improved by 10%, compared to the conventional approach, thanks to the reduction in splicing points and the prevention of fusion loss caused by tapering-induced cladding diameter mismatch. The combiner demonstrates an average pump coupling efficiency of 98.5% and a temperature rise coefficient of less than 10 °C/kW without active cooling. Furthermore, an integrated device based on the combiner is fabricated to shorten the length of delivery fiber, therefore mitigating the effects of stimulated Raman scattering. All those techniques mentioned above are utilized in a narrow linewidth laser system, resulting in an output of approximately 5840 W with a nearly single-mode characteristic. [ABSTRACT FROM AUTHOR]

Published
2023
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208. Optimization and demonstration of 6 kW oscillating-amplifying integrated fiber laser employing spindle-shaped fiber to suppress SRS and TMI

Author

Zeng, Lingfa, primary, Yang, Huan, additional, Xi, Xiaoming, additional, Ye, Yun, additional, Huang, Liangjin, additional, Yang, Baolai, additional, Zhang, Hanwei, additional, Yan, Zhiping, additional, Wang, Xiaolin, additional, Pan, Zhiyong, additional, Wang, Zefeng, additional, and Xu, Xiaojun, additional

Published
2023
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217. Functional Outcome Analysis of Stereotactic Catheter Aspiration for Spontaneous Intracerebral Hemorrhage: Early or Late Hematoma Evacuation?

Author

Fang, Yuanjian, primary, Wang, Junjie, additional, Chen, Luxi, additional, Yan, Wei, additional, Gao, Shiqi, additional, Liu, Yibo, additional, Wang, Xiaoyu, additional, Dong, Xiao, additional, Zhang, Jianmin, additional, Chen, Sheng, additional, Liu, Fengqiang, additional, Wang, Zefeng, additional, and Zhang, Yang, additional

Published
2023
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223. Down-Regulation of HSP by Pd-Cu Nanozymes for NIR Light Triggered Mild-Temperature Photothermal Therapy Against Wound Bacterial Infection: In vitro and in vivo Assessments

Author

Zhou,Yan, Zhou,Zekun, Wu,Xiaojuan, Wang,Zefeng, Qi,Wangdan, Yang,Jing, Qing,Liming, Tang,Juyu, Deng,Le, Zhou,Yan, Zhou,Zekun, Wu,Xiaojuan, Wang,Zefeng, Qi,Wangdan, Yang,Jing, Qing,Liming, Tang,Juyu, and Deng,Le

Abstract

Yan Zhou,1,2,* Zekun Zhou,3,* Xiaojuan Wu,2 Zefeng Wang,2 Wangdan Qi,1 Jing Yang,1 Liming Qing,3 Juyu Tang,3 Le Deng1 1State Key Laboratory of Developmental Biology of Freshwater Fish, Department of Microbiology, College of Life Science, Hunan Normal University, Changsha, Hunan, People’s Republic of China; 2State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province, Changsha, Hunan, People’s Republic of China; 3Department of Orthopedics, Hand and Microsurgery, Xiangya Hospital of Central South University, Changsha, Hunan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Le Deng, State Key Laboratory of Developmental Biology of Freshwater Fish, Department of Microbiology, College of Life Science, Hunan Normal University, Changsha, Hunan, People’s Republic of China, Email dengle@hunnu.edu.cn Juyu Tang, Department of Orthopedics, Hand and Microsurgery, Xiangya Hospital of Central South University, Changsha, Hunan, People’s Republic of China, Email tangjuyu@csu.edu.cnPurpose: We aimed to develop an oxidative-stress-activated palladium-copper nanozyme to reduce bacterial’s heat sensitivity by down-regulating heat shock proteins to overcome the shortcomings of conventional photothermal antimicrobial therapy and achieve mild photothermal bactericidal efficacy.Methods: We first synthesized palladium-copper nanozymes (PC-NPs) by hydration and used transmission electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy to demonstrate their successful preparation. Their photothermal therapy (PTT) and chemo-dynamic therapy (CDT) activities were then determined by a series of photothermal performance tests and peroxidase-like performance tests, and the destruction of heat shock proteins by reactive oxygen species (RO

Published
2023

225. Raman Oscillation Induced by Weak Internal Reflections of Fiber Devices in High-Power Fiber Amplifiers

Author

Chen, Qi, Ren, Shuai, Liu, Wei, Chen, Yisha, Ma, Pengfei, and Wang, Zefeng

Abstract

Stimulated Raman scattering (SRS) is one of the dominant restrictions in power scaling of high-power fiber lasers with diffraction-limited beam quality. In this work, the phenomenon of Raman oscillation induced by weak internal reflections of fiber devices in high-power fiber amplifiers are demonstrated experimentally and theoretically. The experimental results show that layouts of the two fiber devices impact SRS in a high-power fiber amplifier. Further experimental measurements reveal that weak internal reflections of fiber devices are important sources of end-facet reflections. A spectral evolution model is proposed and verifies the impact of weak end-facet reflections on SRS in high-power fiber amplifiers. Further theoretical analysis confirms the phenomenon of Raman oscillation, which is a practical Raman threshold of high-power fiber amplifiers. The overall experimental and theoretical results could provide a well reference for the optimal design of SRS-limited high-power fiber amplifiers.

Published
2024
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226. Splicing dysregulation in cancer: from mechanistic understanding to a new class of therapeutic targets

Author

Wang, Yongbo, Bao, Yufang, Zhang, Sirui, and Wang, Zefeng

Abstract

RNA splicing dysregulation is widespread in cancer. Accumulating evidence demonstrates that splicing defects resulting from splicing dysregulation play critical roles in cancer pathogenesis and can serve as new biomarkers and therapeutic targets for cancer intervention. These findings have greatly deepened the mechanistic understandings of the regulation of alternative splicing in cancer cells, leading to rapidly growing interests in targeting cancer-related splicing defects as new therapies. Here we summarize the current research progress on splicing dysregulation in cancer and highlight the strategies available or under development for targeting RNA splicing defects in cancer.

Published
2024
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227. Flexible Temperature Sensor Array Based on PEDOT:PSS Inkjet Printing

Author

Wu, Sheng, Hu, Zechen, Jiang, Nian, Zhai, Jiayuan, Liu, Yang, Wang, Zefeng, Kang, Chong, and Wang, Yanhui

Abstract

Inkjet-printed micro-electro-mechanical systems are a set of fabrication techniques that use inexpensive printed circuit processes to construct microsensors. Compared with traditional sensors, flexible micro-sensors present excellent application prospects in the fields of medical electronics, environmental monitoring wearable devices, etc. This article developed a simple flexible temperature sensor array based on inkjet-printed micro-electro-mechanical systems by using poly(3,4-ethylenedioxythiophene): polystyrene sulfonate (PEDOT:PSS) as the sensing material. This sensor array employed polyethylene terephthalate (PET), nine silver contact electrodes, and 12 PEDOT:PSS sensing blocks as the bottom substrate, middle layer, and top layer, respectively. There are 12 temperature sensors arrayed on an area of $4\times 4$ cm2, which can realize a thermal resolution of $5\times 5$ temperature pixels using the modeling simulation method. The sensor array showed a sensitivity of -0.50%/°C with a small hysteresis from 25 up to $75~^{\circ }$ C (or in a chosen temperature range), which is higher compared to that of other similar sensors reported in the literature. To improve the accuracy, an array correction algorithm was investigated as a data processing method and succeeded in reducing the temperature error from 0.80% to less than 0.50%. The combination of the array and flexible structures makes our temperature-sensing arrays easy to affix and particularly advantageous for displaying interface heat diffusion behavior, such as the water body’s epidermis.

Published
2024
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232. A Novel Structure for Raman Suppression in Narrow Linewidth Fiber Amplifier

Author

Tian, Xin, Rao, Binyu, Wang, Meng, Xi, Xiaoming, Wang, Chongwei, Liu, Wei, Ma, Pengfei, Chen, Zilun, Xiao, Hu, Fang, Hanxian, and Wang, Zefeng

Abstract

In this letter, we proposed a novel structure for the suppression of stimulated Raman scattering (SRS) in high-power narrow linewidth fiber amplifier seeded by fiber Bragg grating -based oscillator. By introducing broadband external feedback into the laser cavity, an ultra-stable continuous-wave seed was acquired by suppressing the self-pulsations in the fiber oscillator. Accordingly, the SRS threshold of the amplifier was improved significantly. The advantages of this structure and its usability in narrow linewidth fiber lasers have been explained carefully. Based on this novel structure, a 3.5 kW single mode narrow linewidth fiber amplifier was obtained with high signal to Raman ratio of 40 dB. This work provides a simple and effective approach for SRS suppression in high-power narrow linewidth fiber amplifiers.

Published
2023
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233. Damage Identification of Rotating Blades Based on Fuzzy C-Means and Frequency Response Function Curvature Methods.

Author

Cui, Ruize, Wang, Zefeng, and Song, Zhiguang

Subjects
*SINGULAR value decomposition, *FUZZY algorithms, *HAMILTON'S principle function, *CURVATURE, *EQUATIONS of motion, *CLUSTER analysis (Statistics)
Abstract

Rotor blades are one of the key components of helicopter. If the blades are damaged, the safety and reliability of the helicopter will be seriously affected. Therefore, it is necessary to investigate the damage identification of the rotating blades. In this paper, a rotating cantilever beam is used to model the rotor blade. Based on the assumed mode method and Hamilton's principle, the equation of motion is formulated, and the correctness of the model is verified by numerical and experimental studies. Altogether, two methods are used to identify the damages on the blade. The first one is the cluster analysis method based on the fuzzy C-mean theory. In order to reduce the dimension of the signal features, the singular value decomposition is introduced. The second method is the curvature of frequency response function method that can be used to determine the exact position of damages. Simulation results show that one can use fuzzy C-mean method to determine whether there is damage on the blade firstly and then determine the exact position of the damage through the curvature of frequency response function method. [ABSTRACT FROM AUTHOR]

Published
2023
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240. 基于FBG窄谱光纤激光放大器实现新突破

Author

Wang Zefeng, 王泽锋, primary, Tian Xin, 田鑫, additional, Rao Binyu, 饶斌裕, additional, Wang Meng, 王蒙, additional, Xi Xiaoming, 奚小明, additional, Li Zhixian, 李智贤, additional, Chen Zilun, 陈子伦, additional, Xiao Hu, 肖虎, additional, Ma Pengfei, 马鹏飞, additional, Liu Wei, 刘伟, additional, Pan Zhiyong, 潘志勇, additional, Huang Liangjin, 黄良金, additional, Yang Baolai, 杨保来, additional, Wang Xiaolin, 王小林, additional, and Chen Jinbao, 陈金宝, additional

Published
2023
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243. 基于飞秒激光刻写的高功率啁啾倾斜光纤光栅

Author

Li Hao, 李昊, primary, Ye Xinyu, 叶新宇, additional, Wang Meng, 王蒙, additional, Wu Baiyi, 武柏屹, additional, Gao Chenhui, 高晨晖, additional, Chen Zilun, 陈子伦, additional, Wang Zefeng, 王泽锋, additional, and Chen Jinbao, 陈金宝, additional

Published
2023
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244. 2.15 μm全光纤气体拉曼激光光源

Author

Li Ziyan, 李子颜, primary, Pei Wenxi, 裴闻喜, additional, Li Hao, 李昊, additional, Huang Wei, 黄威, additional, Li Xuanxi, 李炫熹, additional, Wang Zefeng, 王泽锋, additional, and Chen Jinbao, 陈金宝, additional

Published
2023
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247. 主动控制光谱合成倾斜抖动实现8 kW近单模输出

Author

Wang Peng, 王鹏, primary, Xi Xiaoming, 奚小明, additional, Meng Xiangming, 孟祥明, additional, Wang Xiaolin, 王小林, additional, Wu Hanshuo, 吴函烁, additional, Yang Baolai, 杨保来, additional, Zhang Hanwei, 张汉伟, additional, Ma Pengfei, 马鹏飞, additional, Ma Yanxing, 马阎星, additional, Liu Wenguang, 刘文广, additional, Xi Fengjie, 习锋杰, additional, Han Kai, 韩凯, additional, Wang Zefeng, 王泽锋, additional, Xu Xiaojun, 许晓军, additional, and Chen Jinbao, 陈金宝, additional

Published
2023
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249. A 110 W fiber gas Raman laser at 1153 nm

Author

Cui, Yulong, primary, Tian, Xin, additional, Rao, Binyu, additional, Li, Hao, additional, Huang, Wei, additional, Pei, Wenxi, additional, Wang, Meng, additional, Chen, Zilun, additional, and Wang, Zefeng, additional

Published
2023
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