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201. Diagnosis of ADHD in Adults: What Is the Appropriate 'DSM-5' Symptom Threshold for Hyperactivity-Impulsivity?

Author

Solanto, Mary V., Wasserstein, Jeanette, and Marks, David J.

Abstract

Objective: To empirically identify the appropriate symptom threshold for hyperactivity-impulsivity for diagnosis of ADHD in adults. Method: Participants were 88 adults (M [SD] age = 41.69 [11.78] years, 66% female, 16% minority) meeting formal "DSM-IV" criteria for ADHD combined or predominantly inattentive subtypes based on a structured diagnostic interview keyed to "DSM-IV" (Conners' Adult ADHD Diagnostic Interview for "DSM-IV" [CAADID]). All participants also completed the Conners' Adult ADHD Rating Scale (CAARS), which was normed on the general adult population and includes subscales for "DSM-IV" inattentive and "DSM-IV" hyperactive-impulsive symptoms. A T-score threshold of 65 (at least 1.5 SD above population mean) on the CAARS "DSM-IV" hyperactive-impulsive dimension was used to identify participants with empirically elevated symptom severity. Results: Of 88 participating adults, 48 (55%) had a T-score of at least 65 (1.5 SD) on the CAARS "DSM-IV" Hyperactive-Impulsive scale. Of these, only 25 (52%) met the "DSM-IV" cutoff of six hyperactive-impulsive symptoms on the CAADID. Thus, approximately half of those who reported empirically elevated hyperactive-impulsive complaints on the CAARS did not concurrently meet the six-symptom DSM-IV cutoff on the CAADID. An alternative cutoff of four hyperactive-impulsive symptoms on the CAADID captured 39 (81%) cases identified by the CAARS. Conclusion: In adults, mandating at least six hyperactive-impulsive symptoms excludes a significant percentage (almost half) of adults who are at least 1.5 SD above the population mean on a dimensional measure of hyperactivity-impulsivity. These data provide a compelling basis for lowering the symptom threshold of hyperactivity-impulsivity for adults in the "DSM-5." (Contains 3 tables.)

Published
2012
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202. Direct medical costs of motorcycle crashes in Ontario

Author

Pincus, Daniel, Wasserstein, David, Nathens, Avery B., Bai, Yu Qing, Redelmeier, Donald A., and Wodchis, Walter P.

Subjects
Ontario. Ministry of Health and Long-Term Care -- Analysis, Economic aspects, Analysis, Health care costs -- Economic aspects -- Analysis, Motorcycles -- Economic aspects -- Analysis, Medical care, Cost of -- Economic aspects -- Analysis
Abstract

Motor vehicle safety has improved substantially over the past 100 years. (1) Between 2000 and 2010, for example, deaths related to motor vehicle crashes decreased by 55.1% in 19 developed [...], BACKGROUND: There is no reliable estimate of costs incurred by motorcycle crashes. Our objective was to calculate the direct costs of all publicly funded medical care provided to individuals after motorcycle crashes compared with automobile crashes. METHODS: We conducted a population-based, matched cohort study of adults in Ontario who presented to hospital because of a motorcycle or automobile crash from 2007 through 2013. For each case, we identified 1 control absent a motor vehicle crash during the study period. Direct costs for each case and control were estimated in 2013 Canadian dollars from the payer perspective using methodology that links health care use to individuals over time. We calculated costs attributable to motorcycle and automobile crashes within 2 years using a difference-in-differences approach. RESULTS: We identified 26831 patients injured in motorcycle crashes and 281826 injured in automobile crashes. Mean costs attributable to motorcycle and automobile crashes were $5825 and $2995, respectively (p < 0.001). The rate of injury was triple for motorcycle crashes compared with automobile crashes (2194 injured annually/100 000 registered motorcycles v. 718 injured annually/100 000 registered automobiles; incidence rate ratio [IRR] 3.1, 95% confidence interval [CI] 2.8 to 3.3, p < 0.001). Severe injuries, defined as those with an Abbreviated Injury Scale > 3, were 10 times greater (125 severe injuries annually/100 000 registered motorcycles v. 12 severe injuries annually/100000 registered automobiles; IRR 10.4, 95% CI 8.3 to 13.1, p < 0.001). INTERPRETATION: Considering both the attributable cost and higher rate of injury, we found that each registered motorcycle in Ontario costs the public health care system 6 times the amount of each registered automobile. Medical costs may provide an additional incentive to improve motorcycle safety.

Published
2017
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203. Hope versus reality: Parent expectations of genomic testing

Author

Sabrina A. Suckiel, Nehama Teitelman, Laurie J. Bauman, Eimear E. Kenny, Katherine E. Donohue, Jacqueline A. Odgis, Bruce D. Gelb, Melissa P. Wasserstein, Siobhan M Dolan, Dana Watnick, Katie Gallagher, and Carol R. Horowitz

Subjects
Parents, Genetic counseling, Genetic Counseling, Sample (statistics), Context (language use), Article, Developmental psychology, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Narrative, Genetic Testing, 030212 general & internal medicine, Child, Motivation, Disappointment, business.industry, 030503 health policy & services, General Medicine, Additional research, Test (assessment), New York City, Personalized medicine, medicine.symptom, 0305 other medical science, Psychology, business
Abstract

Objective Genomics is increasingly used for diagnostic testing in children. This study describes the expectations of parents whose child received genomic testing and whether or not they were met. Methods A diverse stratified, purposive sample of parents of 22 children in New York City was interviewed using a semi-structured guide. Genomic test results were positive, negative, or uncertain. Results Parents expressed their expectations in narrative and numeric fashion. Parents expected that their child’s test would have a direct effect on their child’s diagnosis. Some believed that results would be definitive, while others recognized testing limitations. Expectations reflected parents’ hope to find a diagnosis and led to disappointment when results were uninformative or did not impact clinical management. Conclusion Results suggest pre-test genetic counseling emphasize the low likelihood of actionable results; however, parents’ expectations of genomics’ diagnostic capabilities are strongly rooted in their need to end the diagnostic odyssey and may be difficult to manage. Practice Implications Parents’ hope for a resolution and effective treatment for their child is a powerful context in which genetic counseling is heard. Clinicians who provide genomic testing should continue to acknowledge parents’ preconceptions. Additional research in other settings will help understand how to best address and manage parent expectations of genomic medicine.

Published
2021
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205. Detection of mosaic variants using genome sequencing in a large pediatric cohort

Author

Odgis, Jacqueline A., primary, Gallagher, Katie M., additional, Rehman, Atteeq U., additional, Marathe, Priya N., additional, Bonini, Katherine E., additional, Sebastin, Monisha, additional, Di Biase, Miranda, additional, Brown, Kaitlyn, additional, Kelly, Nicole R., additional, Ramos, Michelle A., additional, Thomas‐Wilson, Amanda, additional, Guha, Saurav, additional, Okur, Volkan, additional, Ganapathi, Mythily, additional, Elkhoury, Lama, additional, Edelmann, Lisa, additional, Zinberg, Randi E., additional, Abul‐Husn, Noura S., additional, Diaz, George A., additional, Greally, John M., additional, Suckiel, Sabrina A., additional, Jobanputra, Vaidehi, additional, Horowitz, Carol R., additional, Kenny, Eimear E., additional, Wasserstein, Melissa P., additional, and Gelb, Bruce D., additional

Published
2022
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206. Consensus clinical management guidelines for Acid Sphingomyelinase Deficiency (Niemann-Pick disease types A, B and A/B)

Author

Geberhiwot, Tarekegn, primary, Wasserstein, Melissa, additional, Wanninayake, Subadra, additional, Bolton, Shaun Christopher, additional, Dardis, Andrea, additional, Lehman, Anna, additional, Lidove, Oliver, additional, Dawson, Charlotte, additional, Giugliani, Roberto, additional, Imrie, Jackie, additional, Hopkin, Justin, additional, Green, James, additional, Corbeira, Daniel de Vicente, additional, Madathil, Shyam, additional, Mengel, Eugen, additional, Ezgu, Fatih, additional, Pettazzoni, Magali, additional, Sjouke, Barbara, additional, Hollak, Carla, additional, Vanier, Marie T, additional, McGovern, Margaret, additional, and Schuchman, Edward, additional

Published
2022
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219. Adult Learning Disorders: Contemporary Issues

Author

Wolf, Lorraine E., Schreiber, Hope E., Wasserstein, Jeanette, Wolf, Lorraine E., Schreiber, Hope E., and Wasserstein, Jeanette

Abstract

Recent advances in neuroimaging and genetics technologies have enhanced our understanding of neurodevelopmental disorders in adults. The authors in this volume not only discuss such advances as they apply to adults with learning disorders, but also address their translation into clinical practice. One cluster of chapters addresses developmental concerns as children and adolescents with learning disorders approach young adulthood. Experts discuss dyslexia, language-based and writing disorders, perhaps the most widely studied group of learning disorders, from the point of view of neuroimaging and genetic underpinnings. Chapters on the neuroscience of nonverbal, math and executive function disorders are also included. Clinically-oriented chapters with case studies, recommendations for accommodation, and considerations for evaluation follow. Study of specialized populations--such as late high school students, college, medical and law students--further demonstrate how our expanded knowledge base may be applicable to clinical practice. The heterogeneity of adults with learning disorders, the complexity of their clinical presentation and co-existing disorders are addressed from both a scientific and clinical point of view demonstrating how empirical research and clinical practice inform each other. This volume will enhance the practice of clinicians and educators working with adults with neurodevelopmental disorders, as well as providing essential current information for researchers of adults with learning disorders. Following an introduction by A.F. Mirsky, this book is divided into four parts. Part 1, Development, contains the following: (1) Normal and LD Development of Academic Skills (J. Cohen Sherman); (2) Sex Differences in Brain Development & Learning Disability (K. Kniele, R. Gur); (3) The Concept of Atypical Brain Development as Applied to Developmental Learning Disorders (J.W. Gilger, B.J. Kaplan). Part 2, Neurobiology and Specific Learning Disorders, contains the following: (4) Developmental Dyslexia in Adults: Implications for Studies of Its Etiology (E.L. Grigorenko); (5) Reading Fluency in Adults (A. Daniels); (6) Structural and Functional Neuroimaging in Language Disorders: Specific Language Impairment and Autism Spectrum Disorders (H. Tager-Flusberg, K. Lindgren, M. Mody); (7) Syndrome of Nonverbal Learning Disabilities in Adults (K.D. Tsatsanis, B.P. Rourke); (8) Disorders of Mathematics: Implications for Adult Functioning (F. Krueger, J. Grafman); and (9) Executive Functioning and Disorders of Self-Regulation in Young Adults (L.E. Wolf, E. Kaplan). Part 3, Diagnosis and Assessment, contains the following: (10) Comprehensive Evaluation of Adults with Learning Disabilities (R. Mapou); (11) TBD (L. Siegel, K. Stanovich); (12) Assessment of Written Expression in the Adult Population (N. Gregg, C. Coleman, J. Hartwig); and (13) Co-existing Psychiatric Disorders in Post-secondary Students Referred for Neuropsychological Evaluation for LD or ADHD (H. Schreiber). Part 4, Life Outcomes, contains the following: (14) Making the Transition to Adulthood for Individuals with Learning Disorders (C. Rey-Casserly, J. Holmes Bernstein); (15) Accommodations: Research to Practice (N. Gregg, D. Morgan, J. Hartwig); (16) Legal Issues for Adults with Learning Disabilities in Higher Education and Employment (A.H. Macurdy, E. Geetter); (17) The Professional Student with a Learning Disorder: Focus on Medicine and Law (C. Weinstein, L.E. Wolf, H. Schreiber); (18) Outcome of NLD Adults: A Naturalistic Study (J. Wasserstein, N.P. Vadhan, G.A. Stefanotis, K. Barboza); and (19) Concluding Thoughts and Future Directions (H. Schreiber, L.E. Wolf, J. Wasserstein). [The introduction was written by A.F. Mirsky.]

Published
2008

220. Development of a New Psychosocial Treatment for Adult ADHD

Author

Solanto, Mary V., Marks, David J., Mitchell, Katherine J., Wasserstein, Jeanette, and Kofman, Michele D.

Abstract

Objective: The purpose of this study was to assess the effectiveness of a new manualized group Meta-Cognitive Therapy (MCT) for adults with ADHD that extends the principles and practices of cognitive-behavioral therapy to the development of executive self-management skills. Method: Thirty adults diagnosed with ADHD completed an 8- or 12-week program designed to target impairments in time management, organization, and planning skills. Treatment efficacy was measured using pre- and posttreatment self-report standardized measures (CAARS-S:L & Brown ADD Scales). Results: General linear modeling revealed a robust significant posttreatment decline on the CAARS "DSM-IV" Inattentive symptom scale (p less than 0.001) as well as improvement on the Brown ADD Scales (p less than 0.001). Conclusion: The findings indicate that participants in the MCT program showed marked improvement with respect to core ADHD symptoms of inattention, as well as executive functioning skills, suggesting that this program has promise as a treatment for meta-cognitive deficits in adults with ADHD.

Published
2008
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221. Effects of hospital funding reform on wait times for hip fracture surgery: a population-based interrupted time-series analysis

Author

David Wasserstein, Alvin H. Li, Daniel Pincus, Anjie Huang, Adalsteinn D. Brown, Monica Taljaard, Lauren Lapointe-Shaw, Noah Ivers, J. Michael Paterson, Karen S. Palmer, and Jessica Widdifield

Subjects
medicine.medical_specialty, Canada, Waiting Lists, Epidemiology, 030204 cardiovascular system & hematology, Interrupted Time Series Analysis, 03 medical and health sciences, Fracture Fixation, Internal, 0302 clinical medicine, medicine, Tibial plateau fracture, Humans, Femur, 030212 general & internal medicine, Ontario, Hip fracture, business.industry, Hip Fractures, General surgery, Health Policy, Retrospective cohort study, medicine.disease, Confidence interval, Hospitals, Orthopaedic Surgery, Retrospective studies, medicine.anatomical_structure, Orthopedic surgery, Ankle, Public aspects of medicine, RA1-1270, business, Research Article
Abstract

Background Health care funding reforms are being used worldwide to improve system performance but may invoke unintended consequences. We assessed the effects of introducing a targeted hospital funding model, based on fixed price and volume, for hip fractures. We hypothesized the policy change was associated with reduction in wait times for hip fracture surgery, increase in wait times for non-hip fracture surgery, and increase in the incidence of after-hours hip fracture surgery. Methods This was a population-based, interrupted time series analysis of 49,097 surgeries for hip fractures, 10,474 for ankle fractures, 1,594 for tibial plateau fractures, and 40,898 for appendectomy at all hospitals in Ontario, Canada between April 2012 and March 2017. We used segmented regression analysis of interrupted monthly time series data to evaluate the impact of funding reform enacted April 1, 2014 on wait time for hip fracture repair (from hospital presentation to surgery) and after-hours provision of surgery (occurring between 1700 and 0700 h). To assess potential adverse consequences of the reform, we also evaluated two control procedures, ankle and tibial plateau fracture surgery. Appendectomy served as a non-orthopedic tracer for assessment of secular trends. Results The difference (95 % confidence interval) between the actual mean wait time and the predicted rate had the policy change not occurred was − 0.46 h (-3.94 h, 3.03 h) for hip fractures, 1.46 h (-3.58 h, 6.50 h) for ankle fractures, -3.22 h (-39.39 h, 32.95 h) for tibial plateau fractures, and 0.33 h (-0.57 h, 1.24 h) for appendectomy (Figure 1; Table 3). The difference (95 % confidence interval) between the actual and predicted percentage of surgeries performed after-hours − 0.90 % (-3.91 %, 2.11 %) for hip fractures, -3.54 % (-11.25 %, 4.16 %) for ankle fractures, 7.09 % (-7.97 %, 22.14 %) for tibial plateau fractures, and 1.07 % (-2.45 %, 4.59 %) for appendectomy. Conclusions We found no significant effects of a targeted hospital funding model based on fixed price and volume on wait times or the provision of after-hours surgery. Other approaches for improving hip fracture wait times may be worth pursuing instead of funding reform.

Published
2021

222. Foam Rubber Pica and Cautopyreiophagia in a Highly Educated Woman: A Clinical Case Study

Author

Kelsey McVey, Tammy Donohue, Eitan Kimchi, Una D. McCann, Taylor Wasserstein, Michael J. Van Wert, Jefferson Curry, and Naomi Goldstick Rosner

Subjects
050103 clinical psychology, Intensive outpatient program, medicine.medical_specialty, business.industry, 05 social sciences, Mental health, 03 medical and health sciences, Psychiatry and Mental health, Clinical Psychology, 0302 clinical medicine, Foam rubber, medicine, 0501 psychology and cognitive sciences, Pica (disorder), Clinical case, medicine.symptom, business, Psychiatry, 030217 neurology & neurosurgery
Abstract

Pica, the developmentally and culturally-inappropriate eating of non-nutritive and non-food substances, is most often documented in people with developmental disabilities and children, frequently in institutional and residential settings. To date, there are no randomized clinical trials on pica-specific treatments, and very little literature is available regarding the characteristics or treatment of pica in adults with no intellectual or social deficits, and co-morbid disorders. This case study addresses this gap, and involves a highly educated 30 year-old American woman with foam rubber pica and burned match consumption (cautopyreiophagia) behaviors, along with co-morbid depressive, anxiety, and obsessive-compulsive symptoms, who received treatment in a general intensive outpatient program for adults in a large urban community psychiatry setting. The case study describes how the Biosocial Theory and Transtheoretical Model of Health Behavior Change were used to conceptualize this woman’s symptoms and guide a treatment team of clinicians who did not specialize in pica. Providers in non-specialty clinic settings would benefit from reflecting on ways to adapt evidence-based techniques to the treatment of uncommon symptoms.

Published
2021
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223. Accelerated Surgery Versus Standard Care in Hip Fracture (HIP ATTACK-1): A Kidney Substudy of a Randomized Clinical Trial

Author

Veevaete, Laurent, le Polain de Waroux, Bernard, Lavand'homme, Patricia, Cornu, Olivier, Tribak, Karim, Yombi, Jean C., Touil, Nassim, Bhutia, Jigme T., Clinckaert, Carol, De Clippeleir, Dirk, Reu, Maike, Patel, Ameen, Tandon, Vikas, Gauthier, Leslie P., Avram, Victoria RA., Winemaker, Mitchell, Tushinski, Daniel M., de Beer, Justin, Worster, Andrew, Simpson, Diane L., Alvarado, Kim A., Gregus, Krysten K., Lawrence, Kelly H., Leong, Darryl P., Joseph, Philip G., Magloire, Patrick, Deheshi, Benjamin, Bisland, Stuart, Wood, Thomas J., Wilson, David AJ., Ofori, Sandra N., Spence, Jessica, Duceppe, Emmanuelle, Tiboni, Maria E., Neary, John D., Adili, Anthony, Cowan, David D., Khanna, Vickas, Zaki, Amna, Farrell, Janet C., MacDonald, Anne Marie, Conen, David, Wong, Steven CW., Karbassi, Arsha, Wright, Douglas S., Shanthanna, Harsha, Ganame, Javier, Cheung, Andrew, Coughlin, Ryan, Khan, Moin, Wikkerink, Spencer, Quraishi, Faraaz A., Lawendy, Abdel-Rahman, Kishta, Waleed, Schemitsch, Emil, Carey, Timothy, Macleod, Mark D., Sanders, David W., Vasarhelyi, Edward, Bartley, Debra, Dresser, George K., Tieszer, Christina, Jenkinson, Richard J., Shadowitz, Steven, Lee, Jacques S., Choi, Stephen, Kreder, Hans J., Nousiainen, Markku, Kunz, Monica R., Tuazon, Ravianne, Shrikumar, Mopina, Ravi, Bheeshma, Wasserstein, David, Stephen, David J.G., Nam, Diane, Henry, Patrick D.G., Wood, Gavin CA., Mann, Stephen M., Jaeger, Melanie T., Sivilotti, Marco LA., Smith, Christopher A., Frank, Christopher C., Grant, Heather, Ploeg, Leone, Yach, Jeff D., Harrison, Mark M., Campbell, Aaron R., Bicknell, Ryan T., Bardana, Davide D., Feibel, Robert J., McIlquham, Katie, Gallant, Catherine, Halman, Samantha, Thiruganasambandamoorth, Venkatesh, Ruggiero, Sara, Hadden, William J., Chen, Brian PJ., Coupal, Stephanie A., McMahon, Stephen J., McLean, Lisa M., Shirali, Hemant R., Haider, Syed Y., Smith, Crystal A., Watts, Evan, Santone, David J., Koo, Kevin, Yee, Allan J., Oyenubi, Ademilola N., Nauth, Aaron, Schemitsch, Emil H., Daniels, Timothy R., Ward, Sarah E., Hall, Jeremy A., Ahn, Henry, Whelan, Daniel B., Atrey, Amit, Khoshbin, Amir, Puskas, David, Droll, Kurt, Cullinan, Claude, Payendeh, Jubin, Lefrancois, Tina, Mozzon, Lise, Marion, Travis, Jacka, Michael J., Greene, James, Menon, Matthew, Stiegelmahr, Robert, Dillane, Derek, Irwin, Marleen, Beaupre, Lauren, Coles, Chad P., Trask, Kelly, MacDonald, Shelley, Trenholm, J.A.I., Oxner, William, Richardson, C.G., Dehghan, Niloofar, Sadoughi, Mehdi, Sharma, Achal, White, Neil J., Olivieri, Loretta, Hunt, Stephen B., Turgeon, Thomas R., Bohm, Eric R., Tran, Sarah, Giilck, Stephen M., Hupel, Tom, Guy, Pierre, O'Brien, Peter J., Duncan, Andrew W., Crawford, Gordon A., Zhou, Junlin, Zhao, Yanrui, Liu, Yang, Shan, Lei, Wu, Anshi, Muñoz, Juan M., Chaudier, Philippe, Douplat, Marion, Fessy, Michel Henri, Piriou, Vincent, Louboutin, Lucie, David, Jean Stephane, Friggeri, Arnaud, Viste, Anthony, Vacheron, Charles Hervé, Li Leung, Frankie Ka, Fang, Christian Xinshuo, Hang Yee, Dennis King, Sancheti, Parag K., Pradhan, Chetan V., Patil, Atul A., Puram, Chetan P., Borate, Madhav P., Kudrimoti, Kiran B., Adhye, Bharati A., Dongre, Himanshu V., John, Bobby, Abraham, Valsamma, Pandey, Ritesh A., Rajkumar, Arti, George, Preetha E., Sigamani, Alben, Stephen, Manesh, Chandran, Nitheesh, Ashraf, Mohammed, Georgekutty, A.M., Sulthan, Ahamad S., Adinarayanan, S., Sharma, Deep, Barnawal, Satish P., Swaminathan, Srinivasan, Bidkar, Prasanna U., Mishra, Sandeep K., Menon, Jagdish, Niranjan, M., Varghese, Z.K., Hiremath, Santosh A., Madhusudhan, N.C., Jawali, Abhijit, Gnanadurai, Kingsly R., George, Carolin E., Maddipati, Tatarao, Mary, K.P., Sharma, Vijay, Farooque, Kamran, Malhotra, Rajesh, Mittal, Samarth, Sawhney, Chavi, Gupta, Babita, Mathur, Purva, Gamangati, Shivanand, Tripathy, Vijaylaxmi, Menon, Prem H., Dhillon, Mandeep S., Chouhan, Devendra K., Patil, Sharanu, Narayan, Ravi, Lal, Purushotham, Bilchod, Prashanth N., Singh, Surya U., Gattu, Uttam V., Dashputra, Ravi P., Rahate, Prashant V., Turiel, Maurizio, Accetta, Riccardo, Perazzo, Paolo, Stella, Daniele, Bonadies, Marika, Colombo, Chiara, De Blasio, Giuseppe, Fozzato, Stefania, Pino, Fabio, Morelli, Ilaria, Ortalda, Alessandro, De Donato, Francesco, Colnaghi, Eleonora, Salini, Vincenzo, Placella, Giacomo, Giardina, Giuseppe, Lombardi, Gaetano, Marcato, Anna, Guzzetti, Luca, Rivetti, Ilaria, Greco, Massimiliano, Khor, H.M., Lai, Hou Yee, Kumar, C.S., Chee, K.H., Loh, P.S., Tan, Kit Mun, Singh, Simmrat, Foo, Li Lian, Prakasam, Komella, Chaw, Sook Hui, Lee, Meng-Li, Ngim, Joanne HL., Boon, Huck Wee, Chin, Im Im, Kleinlugtenbelt, Ydo V., Landman, Ellie BM., Flikweert, Elvira R., Roerdink, Herbert W., Brokelman, Roy BG., Elskamp-Meijerman, Hannie F., Staffhorst, Bas, Cobben, Jan-Hein MG., Umer, Masood, Begum, Dilshad, Anjum, Anila, Hashmi, Pervaiz M., Ahmed, Tashfeen, Rashid, Haroon U., Khattak, Mujahid J., Rashid, Rizwan H., Lakdawala, Riaz H., Noordin, Shahryar, Juman, Naveed M., Khan, Robyna I., Riaz, Muhammad M., Bokhari, Syedah S., Almas, Ayesha, Wahab, Hussain, Ali, Arif, Khan, Hammad N., Khan, Eraj K., Nur, Aamer Nabi, Janjua, Kholood A., Orakzai, Sajjad H., Khan, Abdus S., Mustafa, Khawaja J., Sohail, Mian A., Umar, Muhammad, Khan, Siddra A., Ashraf, Muhammad, Khan, Muhammad K., Shiraz, Muhammad, Furgan, Ahmad, Ślęczka, Paweł, Dąbek, Piotr, Kumoń, Adam, Satora, Wojciech, Ambroży, Wojciech, Święch, Mariusz, Rycombel, Jacek, Grzelak, Adrian, Nowak-Kózka, Ilona, Gucwa, Jaroslaw, Machala, Waldemar, Ramokgopa, Mmampapatla T., Firth, Gregory B., Karera, Mwalimu, Fourtounas, Maria, Singh, Virsen, Biscardi, Anna, Iqbal, Muhammad N., Campbell, Ryan J., Maluleke, Matimba L., Moller, Carien, Nhlapo, Lerato, Maqungo, Sithombo, Flint, Margot, Nejthardt, Marcin B., Chetty, Sean, Venter, Stephen, Guerra-Farfan, Ernesto, Tomas-Hernandez, Jordi, Garcia-Sanchez, Yaiza, Clua, Miriam Garrido, Molero-Garcia, Vicente, Teixidor-Serra, Jordi, Villar-Casares, Maria del Mar, Marsa, Jordi Selga, Porcel-Vazquez, Juan A., Andres- Peiro, Jose-Vicente, Mestre-Torres, Jaume, Guilabert, Patricia, Paños Gozalo, M Luisa, Abarca, Luis, Martin, Nuria, Usua, Gemma, Lalueza-Broto, Pilar, Sanchez-Raya, Judith, Nuñez Camarena, Jorge, Fraguas-Castany, Antoni, Piedra Calle, Carlos, Leiva, Diego Soza, Carrasco, Maria Garcia, Balaguer-Castro, Mariano, Jornet-Gibert, Montsant, Monfort-Mira, Montserrat, Gasset-Teixidor, Alfons, Marcano-Fernández, Francesc Antoni, Simó- Sánchez, Isabel, Mari-Alfonso, Begoña, Yela-Verdú, Christian, Pellejero-García, Raúl, Casas-Codina, Júlia, Iglesias- Sanjuan, Ruben, Balcells-Nolla, Pau, Vila-Sánchez, Oriol, de Bustos, Mercè Bertrana, Castillón, Pablo, Bernaus, Martí, Quintas, Saioa, Gómez, Olga, Salvador, Jordi, Abarca, Javier, Estrada, Cristina, Novellas, Marga, Anglès, Francesc, Dealbert, Alfred, Macho, Oscar, Ivanov, Alexia, Valldosera, Esther, Arroyo, Marta, Pey, Borja, Yuste, Antoni, Mateo, Llorenç, De Caso, Julio, Anaya, Rafael, Higa-Sansone, J.L., Millan, Angelica, Baños, Victoria, Herrera-Mateo, Sergio, Aguado, Hector J., García-Virto, Virginia, Simón-Pérez, Clarisa, Chavez, Sergio, Bragado, María, Plata, María, Guerado, Enrique, Cruz, Encarnacion, Cano, Juan R., Bogallo, Jose M., Sa-ngasoongsong, Paphon, Kulachote, Noratep, Sirisreetreerux, Norachart, Pengrung, Nachapan, Chalacheewa, Theerawat, Arnuntasupakul, Vanlapa, Yingchoncharoen, Teerapat, Naratreekoon, Bundit, Kadry, Miriam A., Thayaparan, Surendini, Babu, Victor, Aframian, Arash, Bentoumi, Souad, Sayan, Amrinder, Abdlaziz, Ihab, Vizcaychipi, Marcela P., Correia, Patricia, Patil, Shashank, Haire, Kevin, Mayor, Amy SE., Dillingham, Sally, Nicholson, Laura, Brooke, Ben T., John, Joby, Nanjayan, Shashi K., Parker, Martyn J., O'Sullivan, Susan, Marmor, Meir T., Matityahu, Amir, McClellan, Robert T., Comstock, Curt, Ding, Anthony, Toogood, Paul, Slobogean, Gerard, O’Toole, Robert, Sciadini, Marcus, Nascone, Jason, O’Hara, Nathan, Ryan, Scott P., Clark, Molly E., Cassidy, Charles, Balonov, Konstantin, Weaver, Tristan, Phieffer, Laura S., Bergese, Sergio D., Marcantonio, Andrew J., Devereaux, P.J., Bhandari, Mohit, Borges, Flavia K., Balasubramanian, Kumar, Bangdiwala, Shrikant I., Harvey, Valerie, McGillion, Michael H., Pettit, Shirley, Vincent, Jessica, Dragic-Taylor, Sanela, Maxwell, Chelsea, Molnar, Sarah, Wells, Jennifer R., Forget, Patrice, Landais, Paul, Landoni, Giovanni, Wang, Chew Yin, Szczeklik, Wojciech, Biccard, Bruce M., Popova, Ekaterine, Moppett, Iain K., Roberts, Robin, Chairperson, McAlister, Finlay, Sackett, David, Wright, James, Cuerden, Meaghan, Sontrop, Jessica M., Guerra-Farfán, Ernesto, Neary, John, Tiboni, Maria, Ramokgopa, Mmampapatla Thomas, Sancheti, Parag, Jenkinson, Richard, Wood, Gavin C.A., McMahon, John Stephen, Tomás-Hernández, Jordi, and Garg, Amit X.

Published
2022
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229. How Typical Is a Median Person?

Author

Higgs, Megan Dailey and Wasserstein, Ron

Abstract

Megan Dailey Higgs, who is a statistician who loves to think and write about the use of statistical inference, reasoning, and methods in scientific research - among other things, reflects on the use of the phrase – median person. While the term "average person" may be more popular, "median person" is gaining in popularity. This column considers the potentially misleading connection between the concepts of media/average person and a "typical" or "common" person. [ABSTRACT FROM AUTHOR]

Published
2025
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233. The Contribution of Decision Support Systems (DSS) to Consolidation of Educational Policies

Author

Klein, Joseph and Wasserstein, Mark

Abstract

Educational policies proposed with and without the aid of Decision Support Systems (DSS) were compared. 120 teachers responded to a questionnaire describing two hypothetical incidents and presenting a series of options with respect to homogeneous and heterogeneous grouping of pupils according to achievement level. After selection of preferred alternatives, the participants were asked to estimate the relative importance of a number of relevant considerations. A DSS program then formulated a second decision based on calculation of the information supplied by each teacher. The findings showed that use of DSS resulted in significantly stronger support for heterogeneity. The paper discusses the differences between DSS-aided and unaided decisions and implications for future division of labor between humans and computers in decision-making processes.

Published
2005

239. Population-Based Screening of Newborns: Findings From the NBS Expansion Study (Part One)

Author

Brower, Amy, primary, Chan, Kee, additional, Williams, Marc, additional, Berry, Susan, additional, Currier, Robert, additional, Rinaldo, Piero, additional, Caggana, Michele, additional, Gaviglio, Amy, additional, Wilcox, William, additional, Steiner, Robert, additional, Holm, Ingrid A., additional, Taylor, Jennifer, additional, Orsini, Joseph J., additional, Brunelli, Luca, additional, Adelberg, Joanne, additional, Bodamer, Olaf, additional, Viall, Sarah, additional, Scharfe, Curt, additional, Wasserstein, Melissa, additional, Chen, Jin Y., additional, Escolar, Maria, additional, Goldenberg, Aaron, additional, Swoboda, Kathryn, additional, Ficicioglu, Can, additional, Matern, Dieter, additional, Lee, Rachel, additional, and Watson, Michael, additional

Published
2022
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241. A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects.

Author

Jinglan Zhang, Véronik Lachance, Adam Schaffner, Xianting Li, Anastasia Fedick, Lauren E Kaye, Jun Liao, Jill Rosenfeld, Naomi Yachelevich, Mary-Lynn Chu, Wendy G Mitchell, Richard G Boles, Ellen Moran, Mari Tokita, Elizabeth Gorman, Kaytee Bagley, Wei Zhang, Fan Xia, Magalie Leduc, Yaping Yang, Christine Eng, Lee-Jun Wong, Raphael Schiffmann, George A Diaz, Ruth Kornreich, Ryan Thummel, Melissa Wasserstein, Zhenyu Yue, and Lisa Edelmann

Subjects
Genetics, QH426-470
Abstract

Genetic leukoencephalopathies (gLEs) are a group of heterogeneous disorders with white matter abnormalities affecting the central nervous system (CNS). The causative mutation in ~50% of gLEs is unknown. Using whole exome sequencing (WES), we identified homozygosity for a missense variant, VPS11: c.2536T>G (p.C846G), as the genetic cause of a leukoencephalopathy syndrome in five individuals from three unrelated Ashkenazi Jewish (AJ) families. All five patients exhibited highly concordant disease progression characterized by infantile onset leukoencephalopathy with brain white matter abnormalities, severe motor impairment, cortical blindness, intellectual disability, and seizures. The carrier frequency of the VPS11: c.2536T>G variant is 1:250 in the AJ population (n = 2,026). VPS11 protein is a core component of HOPS (homotypic fusion and protein sorting) and CORVET (class C core vacuole/endosome tethering) protein complexes involved in membrane trafficking and fusion of the lysosomes and endosomes. The cysteine 846 resides in an evolutionarily conserved cysteine-rich RING-H2 domain in carboxyl terminal regions of VPS11 proteins. Our data shows that the C846G mutation causes aberrant ubiquitination and accelerated turnover of VPS11 protein as well as compromised VPS11-VPS18 complex assembly, suggesting a loss of function in the mutant protein. Reduced VPS11 expression leads to an impaired autophagic activity in human cells. Importantly, zebrafish harboring a vps11 mutation with truncated RING-H2 domain demonstrated a significant reduction in CNS myelination following extensive neuronal death in the hindbrain and midbrain. Thus, our study reveals a defect in VPS11 as the underlying etiology for an autosomal recessive leukoencephalopathy disorder associated with a dysfunctional autophagy-lysosome trafficking pathway.

Published
2016
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242. Biomechanical comparison of 3 medial patellofemoral complex reconstruction techniques shows medial over- constraint but no significant difference in lateralization and contact pressure

Author

Falko Dahm, Hassan Syed, Sebastian Tomescu, Heng An Lin, Yaron Haimovich, Naveen Chandrashekar, Cari Whyne, and David Wasserstein

Subjects
Orthopedics and Sports Medicine
Abstract

The purpose of this study was to investigate biomechanical differences of medial patellofemoral ligament (MPFL) reconstruction, medial quadriceps tendon femoral ligament (MQTFL) reconstruction and a combination of these techniques to restore lateral patellar constraint and contact pressures.Eight fresh frozen cadaver knees were mounted to a custom jig with physiologic quadriceps tendon loading. Flexion angles and contact pressure (CP) were dynamically measured using Tekscan® pressure sensors and Polhemus® Liberty 6 degree of freedom (6DOF) positioning sensors in the following conditions: 1. Intact 2. MPFL and MQTFL deficient 3. MPFL reconstructed 4. Combined MPFL + MQTFL reconstructed 5. MQTFL reconstructed Lateral patellar translation was tested using horizontally directed 30N force applied at 30° of knee flexion. The knees were flexed in dynamic fashion and CP values were recorded for 10°, 20°, 30°, 50°, 70°, and 90° degrees of flexion. Group differences were assessed with ANOVA's followed by pairwise comparisons with Bonferroni correction.MPFL (p=0.002) and combined MPFL/MQTFL (p=0.034) reconstruction significantly reduced patellar lateralization from +19.28% (9.78%, 28.78%) in the deficient condition to -17.57% (-27.84%, -7.29%) and -15.56% (-33.61%, 2.30%) respectively. MPFL reconstruction was most restrictive and MQTFL reconstruction the least -7.29% (-22.01%, 7.45%). No significant differences were found between the three reconstruction techniques. Differences in CP between the three reconstruction techniques were not significant (0.02 MPa) at all flexion angles.The present study found no significant difference for patellar lateralization and patellofemoral CP between MPFL, combined MPFL/MQTFL and MQTFL reconstruction. All 3 techniques resulted in stronger lateral patellar constraint compared to the native state while the MQTFL reconstruction emulated the intact state the closest.Various surgical techniques for medial patellofemoral complex reconstruction can restore patellar stability with similar patellofemoral articular pressures.

Published
2022

243. ¿A dónde fueron los conversos al Islam? Dificultades en el estudio de la conversión al Islam en al-Andalus

Author

David J. Wasserstein

Subjects
islam, conversión, al-andalus, onomástica, nombres, History of Civilization, CB3-482, Islam, BP1-253
Abstract

Este trabajo discute una reciente propuesta para identificar a conversos al Islam en al- Andalus basada en su onomástica tal y como ésta se conserva en los diccionarios biográficos árabes del medievo. Se propone demostrar que esta propuesta no es viable en la práctica y, como consecuencia de ello, que no se puede identificar a tales conversos de forma que puedan someterse a un análisis estadístico.

Published
2012
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245. Practical Significance Take Two— How Can I Help You Today?

Author

LaLonde, Donna and Wasserstein, Ron

Subjects
*DEEP learning, *GENERATIVE artificial intelligence, *NATURAL language processing, *LANGUAGE models
Abstract

This article discusses the implications of artificial intelligence (AI) for the field of statistics. The interviewees, including statisticians from Harvard University, Columbia University, and The University of North Carolina, highlight the need for statisticians to understand the underpinnings of AI methods and to develop approaches that align with statistical principles. They also emphasize the importance of modernizing the statistics curriculum, speeding up the review process, and providing more opportunities for young researchers. The interviewees express excitement about the potential of generative AI and the opportunities for collaboration and data analysis that AI presents. [Extracted from the article]

Published
2024

247. Predictive Validity of the Locus of Control Test in Selection of School Administrators.

Author

Klein, Joseph and Wasserstein-Warnet, Marc

Abstract

Examines whether life experience may alter orientation of locus of control, based on random surveys of 112 Israeli principals and their supervisors. Successful principals have a basic orientation toward an internal locus of control. Regarding work, they tend more toward an external locus than less successful colleagues. (Contains 34 references.) (MLH)

Published
2000

248. Recherche Empirique sur les Processes de reequilibrage de l'attention dans le traitement des problemes educatifs. (Empirical Study on the Process of Redirecting Attention in Educational Problem-Solving.)

Author

Wasserstein-Warnet, Marc M.

Abstract

Asserts that traditional strategies of problem-solving are inadequate and that a new method is needed. Suggests four ways to redirect attention in problem solving: overcoming an instant or linear perception of time, interacting between the problem's components and its whole, searching for the meaning or sense of a problem, and studying the potential influence of the "givens" of a problem. (Contains 45 references.) (CW)

Published
2000

249. Principals' Cognitive Strategies for Changes of Perspective in School Innovation.

Author

Wasserstein-Warnet, M. M. and Klein, J.

Abstract

Uses interviews and observations to explore principals' practices in building new cognitive perception and meaning in 20 Israeli schools. Changes of perception are intrinsically complex. Principals' ability to change perspective results from expertise in handling the interaction between a transformative, open-ended process and a time-cognitive orientation. (Contains 61 references.) (MLH)

Published
2000

250. Worthy winner: Why Rao deserved the "Nobel Prize for statistics".

Author

Wasserstein, Ron

Subjects
*NOBEL Prizes, *STATISTICAL association, *STATISTICS, *AWARDS
Abstract

Ron Wasserstein, executive director of the American Statistical Association and director of the International Prize Foundation, explains why C. R. Rao was awarded the 2023 International Prize in Statistics [ABSTRACT FROM AUTHOR]

Published
2023
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