2,918 results on '"Wright, Margaret"'
Search Results
202. The heritability and genetic correlates of mobile phone use: a twin study of consumer behavior
- Author
-
Miller, Geoffrey, Zhu, Gu, Wright, Margaret J., Hansell, Narelle K., and Martin, Nicholas G.
- Published
- 2012
203. Reading in a Modern Foreign Language: Exploring the Potential Benefits of Reading Strategy Instruction
- Author
-
Wright, Margaret and Brown, Pamela
- Abstract
This paper reports the findings of a small-scale study which focused on reading strategy instruction for learners of French or Spanish as a modern foreign language. The objective of the study was to explore the potential of reading strategy instruction in raising the learner readers' awareness of reading strategies, in extending the range of strategies they employed and in encouraging learners to monitor and reflect upon their reading. Having initially established the learners' existing strategy awareness and use, the researchers embarked upon explicit strategy instruction, during which learner readers' strategy use was promoted and reviewed at regular intervals by means of review exercises and interviews. The findings of the study point to the problematic nature of reading strategy instruction. While indications emerged that strategy training appeared to raise learners' awareness of reading strategies and may have encouraged use by some learners of certain top-down processes, other strategies seem harder to acquire. Some learners do not make the transition to more complex strategies. Nonetheless, strategy training can encourage learner readers to reflect on their strategy use and seems to boost their confidence in their own reading abilities. (Contains 4 figures and 2 tables.)
- Published
- 2006
- Full Text
- View/download PDF
204. Greater male than female variability in regional brain structure across the lifespan
- Author
-
Wierenga, Lara M., Doucet, Gaelle E., Dima, Danai, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn, I, Andreassen, Ole A., Anticevic, Alan, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret, I, Borgwardt, Stefan, Bourque, Josiane, den Braber, Anouk, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M., Buitelaar, Jan K., Busatto, Geraldo F., Calhoun, Vince D., Canales-Rodriguez, Erick J., Cannon, Dara M., Caseras, Xavier, Castellanos, Francisco X., Chaim-Avancini, Tiffany M., Ching, Christopher R. K., Clark, Vincent P., Conrod, Patricia J., Conzelmann, Annette, Crivello, Fabrice, Davey, Christopher G., Dickie, Erin W., Ehrlich, Stefan, Van't Ent, Dennis, Fisher, Simon E., Fouche, Jean-Paul, Franke, Barbara, Fuentes-Claramonte, Paola, de Geus, Eco J. C., Di Giorgio, Annabella, Glahn, David C., Gotlib, Ian H., Grabe, Hans J., Gruber, Oliver, Gruner, Patricia, Gur, Raquel E., Gur, Ruben C., Gurholt, Tiril P., de Haan, Lieuwe, Haatveit, Beathe, Harrison, Ben J., Hartman, Catharina A., Hatton, Sean N., Heslenfeld, Dirk J., van den Heuvel, Odile A., Hickie, Ian B., Hoekstra, Pieter J., Hohmann, Sarah, Holmes, Avram J., Hoogman, Martine, Hosten, Norbert, Howells, Fleur M., Pol, Hilleke E. Hulshoff, Huyser, Chaim, Jahanshad, Neda, James, Anthony C., Jiang, Jiyang, Jonsson, Erik G., Joska, John A., Kalnin, Andrew J., Klein, Marieke, Koenders, Laura, Kolskar, Knut K., Kramer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lazaro, Luisa, Lebedeva, Irina S., Lee, Phil H., Lochner, Christine, Machielsen, Marise W. J., Maingault, Sophie, Martin, Nicholas G., Martinez-Zalacain, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Brenna C., McDonald, Colm, McIntosh, Andrew M., McMahon, Katie L., McPhilemy, Genevieve, van der Meer, Dennis, Menchon, Jose M., Naaijen, Jilly, Nyberg, Lars, Oosterlaan, Jaap, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J., Radua, Joaquim, Reif, Andreas, Richard, Genevieve, Roffman, Joshua L., Rosa, Pedro G. P., Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Sarro, Salvador, Satterthwaite, Theodore D., Saykin, Andrew J., Serpa, Mauricio H., Sim, Kang, Simmons, Andrew, Smoller, Jordan W., Sommer, Iris E., Soriano-Mas, Carles, Stein, Dan J., Strike, Lachlan T., Szeszko, Philip R., Temmingh, Henk S., Thomopoulos, Sophia, I, Tomyshev, Alexander S., Trollor, Julian N., Uhlmann, Anne, Veer, Ilya M., Veltman, Dick J., Voineskos, Aristotle, Volzke, Henry, Walter, Henrik, Wang, Lei, Wang, Yang, Weber, Bernd, Wen, Wei, West, John D., Westlye, Lars T., Whalley, Heather C., Williams, Steven C. R., Wittfeld, Katharina, Wolf, Daniel H., Wright, Margaret J., Yoncheva, Yuliya N., Zanetti, Marcus, V, Ziegler, Georg C., de Zubicaray, Greig, I, Thompson, Paul M., Crone, Eveline A., Frangou, Sophia, Tamnes, Christian K., Wierenga, Lara M., Doucet, Gaelle E., Dima, Danai, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn, I, Andreassen, Ole A., Anticevic, Alan, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret, I, Borgwardt, Stefan, Bourque, Josiane, den Braber, Anouk, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M., Buitelaar, Jan K., Busatto, Geraldo F., Calhoun, Vince D., Canales-Rodriguez, Erick J., Cannon, Dara M., Caseras, Xavier, Castellanos, Francisco X., Chaim-Avancini, Tiffany M., Ching, Christopher R. K., Clark, Vincent P., Conrod, Patricia J., Conzelmann, Annette, Crivello, Fabrice, Davey, Christopher G., Dickie, Erin W., Ehrlich, Stefan, Van't Ent, Dennis, Fisher, Simon E., Fouche, Jean-Paul, Franke, Barbara, Fuentes-Claramonte, Paola, de Geus, Eco J. C., Di Giorgio, Annabella, Glahn, David C., Gotlib, Ian H., Grabe, Hans J., Gruber, Oliver, Gruner, Patricia, Gur, Raquel E., Gur, Ruben C., Gurholt, Tiril P., de Haan, Lieuwe, Haatveit, Beathe, Harrison, Ben J., Hartman, Catharina A., Hatton, Sean N., Heslenfeld, Dirk J., van den Heuvel, Odile A., Hickie, Ian B., Hoekstra, Pieter J., Hohmann, Sarah, Holmes, Avram J., Hoogman, Martine, Hosten, Norbert, Howells, Fleur M., Pol, Hilleke E. Hulshoff, Huyser, Chaim, Jahanshad, Neda, James, Anthony C., Jiang, Jiyang, Jonsson, Erik G., Joska, John A., Kalnin, Andrew J., Klein, Marieke, Koenders, Laura, Kolskar, Knut K., Kramer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lazaro, Luisa, Lebedeva, Irina S., Lee, Phil H., Lochner, Christine, Machielsen, Marise W. J., Maingault, Sophie, Martin, Nicholas G., Martinez-Zalacain, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Brenna C., McDonald, Colm, McIntosh, Andrew M., McMahon, Katie L., McPhilemy, Genevieve, van der Meer, Dennis, Menchon, Jose M., Naaijen, Jilly, Nyberg, Lars, Oosterlaan, Jaap, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J., Radua, Joaquim, Reif, Andreas, Richard, Genevieve, Roffman, Joshua L., Rosa, Pedro G. P., Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Sarro, Salvador, Satterthwaite, Theodore D., Saykin, Andrew J., Serpa, Mauricio H., Sim, Kang, Simmons, Andrew, Smoller, Jordan W., Sommer, Iris E., Soriano-Mas, Carles, Stein, Dan J., Strike, Lachlan T., Szeszko, Philip R., Temmingh, Henk S., Thomopoulos, Sophia, I, Tomyshev, Alexander S., Trollor, Julian N., Uhlmann, Anne, Veer, Ilya M., Veltman, Dick J., Voineskos, Aristotle, Volzke, Henry, Walter, Henrik, Wang, Lei, Wang, Yang, Weber, Bernd, Wen, Wei, West, John D., Westlye, Lars T., Whalley, Heather C., Williams, Steven C. R., Wittfeld, Katharina, Wolf, Daniel H., Wright, Margaret J., Yoncheva, Yuliya N., Zanetti, Marcus, V, Ziegler, Georg C., de Zubicaray, Greig, I, Thompson, Paul M., Crone, Eveline A., Frangou, Sophia, and Tamnes, Christian K.
- Abstract
For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.
- Published
- 2022
- Full Text
- View/download PDF
205. Subcortical volumes across the lifespan : Data from 18,605 healthy individuals aged 3–90 years
- Author
-
Dima, Danai, Modabbernia, Amirhossein, Papachristou, Efstathios, Doucet, Gaelle E, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N, Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn I, Andersson, Micael, Andreasen, Nancy C, Andreassen, Ole A, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K, Busatto, Geraldo F, Buckner, Randy L, Calhoun, Vincent, Canales-Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Castellanos, Francisco X, Cervenka, Simon, Chaim-Avancini, Tiffany M, Ching, Christopher R K, Chubar, Victoria, Clark, Vincent P, Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A, Dale, Anders M, Davey, Christopher, de Geus, Eco J C, de Haan, Lieuwe, de Zubicaray, Greig I, den Braber, Anouk, Dickie, Erin W, Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E, Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Fuentes-Claramonte, Paola, Glahn, David C, Gotlib, Ian H, Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E, Gur, Ruben C, Harrison, Ben J, Hartman, Catharine A, Hatton, Sean N, Heinz, Andreas, Heslenfeld, Dirk J., Hibar, Derrek P, Hickie, Ian B, Ho, Beng-Choon, Hoekstra, Pieter J, Hohmann, Sarah, Holmes, Avram J, Hoogman, Martine, Hosten, Norbert, Howells, Fleur M, Hulshoff Pol, Hilleke E, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L, Jiang, Jiyang, Jönsson, Erik G, Joska, John A, Kahn, Rene, Kalnin, Andrew, Kanai, Ryota, Klein, Marieke, Klyushnik, Tatyana P, Koenders, Laura, Koops, Sanne, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lázaro, Luisa, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W J, Maingault, Sophie, Martin, Nicholas G, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, McDonald, Brenna C, McIntosh, Andrew M, McMahon, Katie L, McPhilemy, Genevieve, Menchón, José M, Medland, Sarah E, Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E, Nyberg, Lars, Oosterlaan, Jaap, de la Foz, Víctor Ortiz-García, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J, Potkin, Steven G, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A, Roffman, Joshua L, Rosa, Pedro G P, Sacchet, Matthew D, Sachdev, Perminder S, Salvador, Raymond, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D, Saykin, Andrew J, Serpa, Mauricio H, Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W, Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J, Strike, Lachlan T, Swagerman, Suzanne C, Tamnes, Christian K, Temmingh, Henk S, Thomopoulos, Sophia I, Tomyshev, Alexander S, Tordesillas-Gutiérrez, Diana, Trollor, Julian N, Turner, Jessica A, Uhlmann, Anne, van den Heuvel, Odile A, van den Meer, Dennis, van der Wee, Nic J A, van Haren, Neeltje E M, Van't Ent, Dennis, van Erp, Theo G M, Veer, Ilya M, Veltman, Dick J, Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H, Weber, Bernd, Wen, Wei, West, John D, Westlye, Lars T, Whalley, Heather, Wierenga, Lara M, Williams, Steven C R, Wittfeld, Katharina, Wolf, Daniel H, Worker, Amanda, Wright, Margaret J, Yang, Kun, Yoncheva, Yulyia, Zanetti, Marcus V, Ziegler, Georg C, Thompson, Paul M, Frangou, Sophia, other, and, Dima, Danai, Modabbernia, Amirhossein, Papachristou, Efstathios, Doucet, Gaelle E, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N, Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn I, Andersson, Micael, Andreasen, Nancy C, Andreassen, Ole A, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K, Busatto, Geraldo F, Buckner, Randy L, Calhoun, Vincent, Canales-Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Castellanos, Francisco X, Cervenka, Simon, Chaim-Avancini, Tiffany M, Ching, Christopher R K, Chubar, Victoria, Clark, Vincent P, Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A, Dale, Anders M, Davey, Christopher, de Geus, Eco J C, de Haan, Lieuwe, de Zubicaray, Greig I, den Braber, Anouk, Dickie, Erin W, Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E, Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Fuentes-Claramonte, Paola, Glahn, David C, Gotlib, Ian H, Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E, Gur, Ruben C, Harrison, Ben J, Hartman, Catharine A, Hatton, Sean N, Heinz, Andreas, Heslenfeld, Dirk J., Hibar, Derrek P, Hickie, Ian B, Ho, Beng-Choon, Hoekstra, Pieter J, Hohmann, Sarah, Holmes, Avram J, Hoogman, Martine, Hosten, Norbert, Howells, Fleur M, Hulshoff Pol, Hilleke E, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L, Jiang, Jiyang, Jönsson, Erik G, Joska, John A, Kahn, Rene, Kalnin, Andrew, Kanai, Ryota, Klein, Marieke, Klyushnik, Tatyana P, Koenders, Laura, Koops, Sanne, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lázaro, Luisa, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W J, Maingault, Sophie, Martin, Nicholas G, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, McDonald, Brenna C, McIntosh, Andrew M, McMahon, Katie L, McPhilemy, Genevieve, Menchón, José M, Medland, Sarah E, Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E, Nyberg, Lars, Oosterlaan, Jaap, de la Foz, Víctor Ortiz-García, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J, Potkin, Steven G, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A, Roffman, Joshua L, Rosa, Pedro G P, Sacchet, Matthew D, Sachdev, Perminder S, Salvador, Raymond, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D, Saykin, Andrew J, Serpa, Mauricio H, Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W, Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J, Strike, Lachlan T, Swagerman, Suzanne C, Tamnes, Christian K, Temmingh, Henk S, Thomopoulos, Sophia I, Tomyshev, Alexander S, Tordesillas-Gutiérrez, Diana, Trollor, Julian N, Turner, Jessica A, Uhlmann, Anne, van den Heuvel, Odile A, van den Meer, Dennis, van der Wee, Nic J A, van Haren, Neeltje E M, Van't Ent, Dennis, van Erp, Theo G M, Veer, Ilya M, Veltman, Dick J, Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H, Weber, Bernd, Wen, Wei, West, John D, Westlye, Lars T, Whalley, Heather, Wierenga, Lara M, Williams, Steven C R, Wittfeld, Katharina, Wolf, Daniel H, Worker, Amanda, Wright, Margaret J, Yang, Kun, Yoncheva, Yulyia, Zanetti, Marcus V, Ziegler, Georg C, Thompson, Paul M, Frangou, Sophia, and other, and
- Abstract
Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
- Published
- 2022
206. Greater male than female variability in regional brain structure across the lifespan
- Author
-
Wierenga, Lara M, Doucet, Gaelle E, Dima, Danai, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N, Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn I, Andreassen, Ole A, Anticevic, Alan, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, den Braber, Anouk, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K, Busatto, Geraldo F, Calhoun, Vince D, Canales-Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Castellanos, Francisco X, Chaim-Avancini, Tiffany M, Ching, Christopher Rk, Clark, Vincent P, Conrod, Patricia J, Conzelmann, Annette, Crivello, Fabrice, Davey, Christopher G, Dickie, Erin W, Ehrlich, Stefan, Van't Ent, Dennis, Fisher, Simon E, Fouche, Jean-Paul, Franke, Barbara, Fuentes-Claramonte, Paola, de Geus, Eco Jc, Giorgio, Annabella Di, Glahn, David C, Gotlib, Ian H, Grabe, Hans J, Gruber, Oliver, Gruner, Patricia, Gur, Raquel E, Gur, Ruben C, Gurholt, Tiril P, de Haan, Lieuwe, Haatveit, Beathe, Harrison, Ben J, Hartman, Catharina A, Hatton, Sean N, Heslenfeld, Dirk J, van den Heuvel, Odile A, Hickie, Ian B, Hoekstra, Pieter J, Hohmann, Sarah, Holmes, Avram J, Hoogman, Martine, Hosten, Norbert, Howells, Fleur M, Hulshoff Pol, Hilleke E, Huyser, Chaim, Jahanshad, Neda, James, Anthony C, Jiang, Jiyang, Jönsson, Erik G, Joska, John A, Kalnin, Andrew J, Klein, Marieke, Koenders, Laura, Kolskår, Knut K, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lazaro, Luisa, Lebedeva, Irina S, Lee, Phil H, Lochner, Christine, Machielsen, Marise Wj, Maingault, Sophie, Martin, Nicholas G, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Brenna C, McDonald, Colm, McIntosh, Andrew M, McMahon, Katie L, McPhilemy, Genevieve, van der Meer, Dennis, Menchón, José M, Naaijen, Jilly, Nyberg, Lars, Oosterlaan, Jaap, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J, Radua, Joaquim, Reif, Andreas, Richard, Geneviève, Roffman, Joshua L, Rosa, Pedro Gp, Sacchet, Matthew D, Sachdev, Perminder S, Salvador, Raymond, Sarró, Salvador, Satterthwaite, Theodore D, Saykin, Andrew J, Serpa, Mauricio H, Sim, Kang, Simmons, Andrew, Smoller, Jordan W, Sommer, Iris E, Soriano-Mas, Carles, Stein, Dan J, Strike, Lachlan T, Szeszko, Philip R, Temmingh, Henk S, Thomopoulos, Sophia I, Tomyshev, Alexander S, Trollor, Julian N, Uhlmann, Anne, Veer, Ilya M, Veltman, Dick J, Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Wang, Lei, Wang, Yang, Weber, Bernd, Wen, Wei, West, John D, Westlye, Lars T, Whalley, Heather C, Williams, Steven Cr, Wittfeld, Katharina, Wolf, Daniel H, Wright, Margaret J, Yoncheva, Yuliya N, Zanetti, Marcus V, Ziegler, Georg C, de Zubicaray, Greig I, Thompson, Paul M., Crone, Eveline A, Frangou, Sophia, Tamnes, Christian K, Wierenga, Lara M, Doucet, Gaelle E, Dima, Danai, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N, Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn I, Andreassen, Ole A, Anticevic, Alan, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, den Braber, Anouk, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K, Busatto, Geraldo F, Calhoun, Vince D, Canales-Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Castellanos, Francisco X, Chaim-Avancini, Tiffany M, Ching, Christopher Rk, Clark, Vincent P, Conrod, Patricia J, Conzelmann, Annette, Crivello, Fabrice, Davey, Christopher G, Dickie, Erin W, Ehrlich, Stefan, Van't Ent, Dennis, Fisher, Simon E, Fouche, Jean-Paul, Franke, Barbara, Fuentes-Claramonte, Paola, de Geus, Eco Jc, Giorgio, Annabella Di, Glahn, David C, Gotlib, Ian H, Grabe, Hans J, Gruber, Oliver, Gruner, Patricia, Gur, Raquel E, Gur, Ruben C, Gurholt, Tiril P, de Haan, Lieuwe, Haatveit, Beathe, Harrison, Ben J, Hartman, Catharina A, Hatton, Sean N, Heslenfeld, Dirk J, van den Heuvel, Odile A, Hickie, Ian B, Hoekstra, Pieter J, Hohmann, Sarah, Holmes, Avram J, Hoogman, Martine, Hosten, Norbert, Howells, Fleur M, Hulshoff Pol, Hilleke E, Huyser, Chaim, Jahanshad, Neda, James, Anthony C, Jiang, Jiyang, Jönsson, Erik G, Joska, John A, Kalnin, Andrew J, Klein, Marieke, Koenders, Laura, Kolskår, Knut K, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lazaro, Luisa, Lebedeva, Irina S, Lee, Phil H, Lochner, Christine, Machielsen, Marise Wj, Maingault, Sophie, Martin, Nicholas G, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Brenna C, McDonald, Colm, McIntosh, Andrew M, McMahon, Katie L, McPhilemy, Genevieve, van der Meer, Dennis, Menchón, José M, Naaijen, Jilly, Nyberg, Lars, Oosterlaan, Jaap, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J, Radua, Joaquim, Reif, Andreas, Richard, Geneviève, Roffman, Joshua L, Rosa, Pedro Gp, Sacchet, Matthew D, Sachdev, Perminder S, Salvador, Raymond, Sarró, Salvador, Satterthwaite, Theodore D, Saykin, Andrew J, Serpa, Mauricio H, Sim, Kang, Simmons, Andrew, Smoller, Jordan W, Sommer, Iris E, Soriano-Mas, Carles, Stein, Dan J, Strike, Lachlan T, Szeszko, Philip R, Temmingh, Henk S, Thomopoulos, Sophia I, Tomyshev, Alexander S, Trollor, Julian N, Uhlmann, Anne, Veer, Ilya M, Veltman, Dick J, Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Wang, Lei, Wang, Yang, Weber, Bernd, Wen, Wei, West, John D, Westlye, Lars T, Whalley, Heather C, Williams, Steven Cr, Wittfeld, Katharina, Wolf, Daniel H, Wright, Margaret J, Yoncheva, Yuliya N, Zanetti, Marcus V, Ziegler, Georg C, de Zubicaray, Greig I, Thompson, Paul M., Crone, Eveline A, Frangou, Sophia, and Tamnes, Christian K
- Abstract
For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.
- Published
- 2022
207. Genetic Specificity of Hippocampal Subfield Volumes, Relative to Hippocampal Formation, Identified in 2148 Young Adult Twins and Siblings
- Author
-
Hansell, Narelle K, Strike, Lachlan T, van Eijk, Liza, O'Callaghan, Victoria, Martin, Nicholas G, de Zubicaray, Greig I., Thompson, Paul M, McMahon, Katie L, Wright, Margaret J, Hansell, Narelle K, Strike, Lachlan T, van Eijk, Liza, O'Callaghan, Victoria, Martin, Nicholas G, de Zubicaray, Greig I., Thompson, Paul M, McMahon, Katie L, and Wright, Margaret J
- Abstract
The hippocampus is a complex brain structure with key roles in cognitive and emotional processing and with subregion abnormalities associated with a range of disorders and psychopathologies. Here we combine data from two large independent young adult twin/sibling cohorts to obtain the most accurate estimates to date of genetic covariation between hippocampal subfield volumes and the hippocampus as a single volume. The combined sample included 2148 individuals, comprising 1073 individuals from 627 families (mean age = 22.3 years) from the Queensland Twin IMaging (QTIM) Study, and 1075 individuals from 454 families (mean age = 28.8 years) from the Human Connectome Project (HCP). Hippocampal subfields were segmented using FreeSurfer version 6.0 (CA4 and dentate gyrus were phenotypically and genetically indistinguishable and were summed to a single volume). Multivariate twin modeling was conducted in OpenMx to decompose variance into genetic and environmental sources. Bivariate analyses of hippocampal formation and each subfield volume showed that 10%-72% of subfield genetic variance was independent of the hippocampal formation, with greatest specificity found for the smaller volumes; for example, CA2/3 with 42% of genetic variance being independent of the hippocampus; fissure (63%); fimbria (72%); hippocampus-amygdala transition area (41%); parasubiculum (62%). In terms of genetic influence, whole hippocampal volume is a good proxy for the largest hippocampal subfields, but a poor substitute for the smaller subfields. Additive genetic sources accounted for 49%-77% of total variance for each of the subfields in the combined sample multivariate analysis. In addition, the multivariate analyses were sufficiently powered to identify common environmental influences (replicated in QTIM and HCP for the molecular layer and CA4/dentate gyrus, and accounting for 7%-16% of total variance for 8 of 10 subfields in the combined sample). This provides the clearest indication yet fr
- Published
- 2022
208. Persistence of Anxiety/Depression Symptoms in Early Adolescence: A Prospective Study of Daily Life Stress, Rumination, and Daytime Sleepiness in a Genetically Informative Cohort
- Author
-
Hansell, Narelle K, Strike, Lachlan T, de Zubicaray, Greig I, Thompson, Paul M., McMahon, Katie L, Wright, Margaret J, Hansell, Narelle K, Strike, Lachlan T, de Zubicaray, Greig I, Thompson, Paul M., McMahon, Katie L, and Wright, Margaret J
- Abstract
In this prospective study of mental health, we examine the influence of three interrelated traits - perceived stress, rumination, and daytime sleepiness - and their association with symptoms of anxiety and depression in early adolescence. Given the known associations between these traits, an important objective is to determine the extent to which they may independently predict anxiety/depression symptoms. Twin pairs from the Queensland Twin Adolescent Brain (QTAB) project were assessed on two occasions (N = 211 pairs aged 9-14 years at baseline and 152 pairs aged 10-16 years at follow-up). Linear regression models and quantitative genetic modeling were used to analyze the data. Prospectively, perceived stress, rumination, and daytime sleepiness accounted for 8-11% of the variation in later anxiety/depression; familial influences contributed strongly to these associations. However, only perceived stress significantly predicted change in anxiety/depression, accounting for 3% of variance at follow-up after adjusting for anxiety/depression at baseline, although it did not do so independently of rumination and daytime sleepiness. Bidirectional effects were found between all traits over time. These findings suggest an underlying architecture that is shared, to some degree, by all traits, while the literature points to hypothalamic-pituitary-adrenal (HPA) axis and/or circadian systems as potential sources of overlapping influence and possible avenues for intervention.
- Published
- 2022
209. Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years
- Author
-
Frangou, Sophia, Modabbernia, Amirhossein, Williams, Steven C R, Papachristou, Efstathios, Doucet, Gaelle E, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N, Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn I, Andersson, Micael, Andreasen, Nancy C, Andreassen, Ole A, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K, Busatto, Geraldo F, Buckner, Randy L, Calhoun, Vincent, Canales-Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Castellanos, Francisco X, Cervenka, Simon, Chaim-Avancini, Tiffany M, Ching, Christopher R K, Chubar, Victoria, Clark, Vincent P, Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A, Dale, Anders M, Davey, Christopher, de Geus, Eco J C, de Haan, Lieuwe, de Zubicaray, Greig I, den Braber, Anouk, Dickie, Erin W, Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E, Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Fuentes-Claramonte, Paola, Glahn, David C, Gotlib, Ian H, Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E, Gur, Ruben C, Harrison, Ben J, Hartman, Catharine A, Hatton, Sean N, Heinz, Andreas, Heslenfeld, Dirk J, Hibar, Derrek P, Hickie, Ian B, Ho, Beng-Choon, Hoekstra, Pieter J, Hohmann, Sarah, Holmes, Avram J, Hoogman, Martine, Hosten, Norbert, Howells, Fleur M, Hulshoff Pol, Hilleke E, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L, Jiang, Jiyang, Jönsson, Erik G, Joska, John A, Kahn, Rene, Kalnin, Andrew, Kanai, Ryota, Klein, Marieke, Klyushnik, Tatyana P, Koenders, Laura, Koops, Sanne, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lázaro, Luisa, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W J, Maingault, Sophie, Martin, Nicholas G, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, McDonald, Brenna C, McIntosh, Andrew M, McMahon, Katie L, McPhilemy, Genevieve, Menchón, José M, Medland, Sarah E, Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E, Nyberg, Lars, Oosterlaan, Jaap, de la Foz, Víctor Ortiz-García, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J, Potkin, Steven G, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A, Roffman, Joshua L, Rosa, Pedro G P, Sacchet, Matthew D, Sachdev, Perminder S, Salvador, Raymond, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D, Saykin, Andrew J, Serpa, Mauricio H, Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W, Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J, Strike, Lachlan T, Swagerman, Suzanne C, Tamnes, Christian K, Temmingh, Henk S, Thomopoulos, Sophia I, Tomyshev, Alexander S, Tordesillas-Gutiérrez, Diana, Trollor, Julian N, Turner, Jessica A, Uhlmann, Anne, van den Heuvel, Odile A, van den Meer, Dennis, van der Wee, Nic J A, van Haren, Neeltje E M, van 't Ent, Dennis, van Erp, Theo G M, Veer, Ilya M, Veltman, Dick J, Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H, Weber, Bernd, Wen, Wei, West, John D, Westlye, Lars T, Whalley, Heather, Wierenga, Lara M, Wittfeld, Katharina, Wolf, Daniel H, Worker, Amanda, Wright, Margaret J, Yang, Kun, Yoncheva, Yulyia, Zanetti, Marcus V, Ziegler, Georg C, Thompson, Paul M, Dima, Danai, other, and, Frangou, Sophia, Modabbernia, Amirhossein, Williams, Steven C R, Papachristou, Efstathios, Doucet, Gaelle E, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N, Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn I, Andersson, Micael, Andreasen, Nancy C, Andreassen, Ole A, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K, Busatto, Geraldo F, Buckner, Randy L, Calhoun, Vincent, Canales-Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Castellanos, Francisco X, Cervenka, Simon, Chaim-Avancini, Tiffany M, Ching, Christopher R K, Chubar, Victoria, Clark, Vincent P, Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A, Dale, Anders M, Davey, Christopher, de Geus, Eco J C, de Haan, Lieuwe, de Zubicaray, Greig I, den Braber, Anouk, Dickie, Erin W, Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E, Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Fuentes-Claramonte, Paola, Glahn, David C, Gotlib, Ian H, Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E, Gur, Ruben C, Harrison, Ben J, Hartman, Catharine A, Hatton, Sean N, Heinz, Andreas, Heslenfeld, Dirk J, Hibar, Derrek P, Hickie, Ian B, Ho, Beng-Choon, Hoekstra, Pieter J, Hohmann, Sarah, Holmes, Avram J, Hoogman, Martine, Hosten, Norbert, Howells, Fleur M, Hulshoff Pol, Hilleke E, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L, Jiang, Jiyang, Jönsson, Erik G, Joska, John A, Kahn, Rene, Kalnin, Andrew, Kanai, Ryota, Klein, Marieke, Klyushnik, Tatyana P, Koenders, Laura, Koops, Sanne, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lázaro, Luisa, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W J, Maingault, Sophie, Martin, Nicholas G, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, McDonald, Brenna C, McIntosh, Andrew M, McMahon, Katie L, McPhilemy, Genevieve, Menchón, José M, Medland, Sarah E, Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E, Nyberg, Lars, Oosterlaan, Jaap, de la Foz, Víctor Ortiz-García, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J, Potkin, Steven G, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A, Roffman, Joshua L, Rosa, Pedro G P, Sacchet, Matthew D, Sachdev, Perminder S, Salvador, Raymond, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D, Saykin, Andrew J, Serpa, Mauricio H, Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W, Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J, Strike, Lachlan T, Swagerman, Suzanne C, Tamnes, Christian K, Temmingh, Henk S, Thomopoulos, Sophia I, Tomyshev, Alexander S, Tordesillas-Gutiérrez, Diana, Trollor, Julian N, Turner, Jessica A, Uhlmann, Anne, van den Heuvel, Odile A, van den Meer, Dennis, van der Wee, Nic J A, van Haren, Neeltje E M, van 't Ent, Dennis, van Erp, Theo G M, Veer, Ilya M, Veltman, Dick J, Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H, Weber, Bernd, Wen, Wei, West, John D, Westlye, Lars T, Whalley, Heather, Wierenga, Lara M, Wittfeld, Katharina, Wolf, Daniel H, Worker, Amanda, Wright, Margaret J, Yang, Kun, Yoncheva, Yulyia, Zanetti, Marcus V, Ziegler, Georg C, Thompson, Paul M, Dima, Danai, and other, and
- Abstract
Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
- Published
- 2022
210. Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people
- Author
-
Eising, Else, Mirza-Schreiber, Nazanin, de Zeeuw, Eveline L., Wang, Carol A., Truong, Dongnhu T., Allegrini, Andrea G., Shapland, Chin Yang, Zhu Gu, Wigg, Karen G., Gerritse, Margot, Molz, Barbara, Alagöz, Gökberk, Gialluisi, Alessandro, Abbondanza, Filippo, Rimfeld, Kaili, van Donkelaar, Marjolein, Liao Zhijie, Jansen, Philip R., Andlauer, Till F.M., Bates, Timothy C., Bernard, Manon, Blokland, Kirsten, Bonte, Milene, Børglum Anders D., Bourgeron, Thomas, Brandeis, Daniel, Ceroni, Fabiola, Csépe, Valeria, Dale, Philip S., de Jong, Peter F., DeFries, John C., Demontis, Ditte, Feng Yu, Gordon, Scott D., Guger, Sharon L., Hayiou-Thomas, Marianna E., Hernández-Cabrera, Juan A., Hottenga, Jouke-Jan, Hulme, Charles, Kere, Juha, Kerr, Elizabeth N., Koomar, Tanner, Landerl, Karin, Leonard, Gabriel, Lovett, Maureen W., Lyytinen, Heikki, Martin, Nicholas G., Martinelli, Angela, Maurer, Urs, Michaelson, Jacob J., Moll, Kristina, Monaco, Anthnony P., Morgan, Angela T., Noethen, Markus M., Pausova, Zdenka, Pennell, Craig E., Pennington, Bruce F., Price, Kaitlyn M., Rajagopal, Veera M., Ramus, Franck, Richer, Louis, Simpson, Nuala H., Smith, Shelley, Snowling, Margaret J., Stein, John, Strug, Lisa J., Talcott, Joel B., Tiemeier, Henning, van der Schroeff, Marc M.P., Verhoef, Ellen, Watkins, Kate E., Wilkinson, Margaret, Wright, Margaret J., Barr, Cathy L., Boomsma, Dorret I., Carreiras, Manuel, Franken, Marie-Christine J., Gruen, Jeffrey R., Luciano, Michelle, Müller-Myhsok, Bertram, Newbury, Dianne F., Olson, Richard K., Paracchini, Silvia, Paus, Tomas, Plomin, Robert, Reilly, Sheena, Schulte-Körne, Gerd, Tomblin, Bruce, van Bergen, Elsje, Whitehouse, Andrew J.O., Willcutt, Erik G., St Pourcain, Beate, Francks, Clyde, Fisher, Simon E., Eising, Else, Mirza-Schreiber, Nazanin, de Zeeuw, Eveline L., Wang, Carol A., Truong, Dongnhu T., Allegrini, Andrea G., Shapland, Chin Yang, Zhu Gu, Wigg, Karen G., Gerritse, Margot, Molz, Barbara, Alagöz, Gökberk, Gialluisi, Alessandro, Abbondanza, Filippo, Rimfeld, Kaili, van Donkelaar, Marjolein, Liao Zhijie, Jansen, Philip R., Andlauer, Till F.M., Bates, Timothy C., Bernard, Manon, Blokland, Kirsten, Bonte, Milene, Børglum Anders D., Bourgeron, Thomas, Brandeis, Daniel, Ceroni, Fabiola, Csépe, Valeria, Dale, Philip S., de Jong, Peter F., DeFries, John C., Demontis, Ditte, Feng Yu, Gordon, Scott D., Guger, Sharon L., Hayiou-Thomas, Marianna E., Hernández-Cabrera, Juan A., Hottenga, Jouke-Jan, Hulme, Charles, Kere, Juha, Kerr, Elizabeth N., Koomar, Tanner, Landerl, Karin, Leonard, Gabriel, Lovett, Maureen W., Lyytinen, Heikki, Martin, Nicholas G., Martinelli, Angela, Maurer, Urs, Michaelson, Jacob J., Moll, Kristina, Monaco, Anthnony P., Morgan, Angela T., Noethen, Markus M., Pausova, Zdenka, Pennell, Craig E., Pennington, Bruce F., Price, Kaitlyn M., Rajagopal, Veera M., Ramus, Franck, Richer, Louis, Simpson, Nuala H., Smith, Shelley, Snowling, Margaret J., Stein, John, Strug, Lisa J., Talcott, Joel B., Tiemeier, Henning, van der Schroeff, Marc M.P., Verhoef, Ellen, Watkins, Kate E., Wilkinson, Margaret, Wright, Margaret J., Barr, Cathy L., Boomsma, Dorret I., Carreiras, Manuel, Franken, Marie-Christine J., Gruen, Jeffrey R., Luciano, Michelle, Müller-Myhsok, Bertram, Newbury, Dianne F., Olson, Richard K., Paracchini, Silvia, Paus, Tomas, Plomin, Robert, Reilly, Sheena, Schulte-Körne, Gerd, Tomblin, Bruce, van Bergen, Elsje, Whitehouse, Andrew J.O., Willcutt, Erik G., St Pourcain, Beate, Francks, Clyde, and Fisher, Simon E.
- Abstract
The use of spoken and written language is a fundamental human capacity. Individual differences in reading- and language-related skills are influenced by genetic variation, with twin-based heritability estimates of 30-80%, depending on the trait. The genetic architecture is complex, heterogeneous, and multifactorial, but investigations of contributions of single-nucleotide polymorphisms (SNPs) were thus far underpowered. We present a multicohort genome-wide association study (GWAS) of five traits assessed individually using psychometric measures: word reading, nonword reading, spelling, phoneme awareness, and nonword repetition, in samples of 13,633 to 33,959 participants aged 5-26 years. We identified genome-wide significant association with word reading (rs11208009, p=1.098 x 10-8) at a locus that has not been associated with intelligence or educational attainment. All five reading-/language-related traits showed robust SNP-heritability, accounting for 13-26% of trait variability. Genomic structural equation modelling revealed a shared genetic factor explaining most variation in word/nonword reading, spelling, and phoneme awareness, which only partially overlapped with genetic variation contributing to nonword repetition, intelligence and educational attainment. A multivariate GWAS of word/nonword reading, spelling, and phoneme awareness maximized power for follow-up investigation. Genetic correlation analysis of multivariate GWAS results with neuroimaging traits identified association with the surface area of the banks of the left superior temporal sulcus, a brain region linked to processing of spoken and written language. Heritability was enriched for genomic elements regulating gene expression in the fetal brain, and in chromosomal regions that are depleted of Neanderthal variants. Together, these results provide new avenues for deciphering the biological underpinnings of uniquely human traits.
- Published
- 2022
211. Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
- Author
-
Howe, Laurence J., Nivard, Michel G., Morris, Tim T., Hansen, Ailin F., Rasheed, Humaira, Cho, Yoonsu, Chittoor, Geetha, Ahlskog, Rafael, Lind, Penelope A., Palviainen, Teemu, van der Zee, Matthijs D., Cheesman, Rosa, Mangino, Massimo, Wang, Yunzhang, Li, Shuai, Klaric, Lucija, Ratliff, Scott M., Bielak, Lawrence F., Nygaard, Marianne, Giannelis, Alexandros, Willoughby, Emily A., Reynolds, Chandra A., Balbona, Jared, Andreassen, Ole A., Ask, Helga, Baras, Aris, Bauer, Christopher R., Boomsma, Dorret, Campbell, Archie, Campbell, Harry, Chen, Zhengming, Christofidou, Paraskevi, Corfield, Elizabeth, Dahm, Christina C., Dokuru, Deepika R., Evans, Luke M., de Geus, Eco J. C., Giddaluru, Sudheer, Gordon, Scott D., Harden, K. Paige, Hill, W. David, Hughes, Amanda, Kerr, Shona M., Kim, Yongkang, Kweon, Hyeokmoon, Latvala, Antti, Lawlor, Deborah A., Li, Liming, Lin, Kuang, Magnus, Per, Magnusson, Patrik K. E., Mallard, Travis T., Martikainen, Pekka, Mills, Melinda C., Njolstad, Pal Rasmus, Overton, John D., Pedersen, Nancy L., Porteous, David J., Reid, Jeffrey, Silventoinen, Karri, Southey, Melissa C., Stoltenberg, Camilla, Tucker-Drob, Elliot M., Wright, Margaret J., Hewitt, John K., Keller, Matthew C., Stallings, Michael C., Lee, James J., Christensen, Kaare, Kardia, Sharon L. R., Peyser, Patricia A., Smith, Jennifer A., Wilson, James F., Hopper, John L., Hagg, Sara, Spector, Tim D., Pingault, Jean-Baptiste, Plomin, Robert, Havdahl, Alexandra, Bartels, Meike, Martin, Nicholas G., Oskarsson, Sven, Justice, Anne E., Millwood, Iona Y., Hveem, Kristian, Naess, Oyvind, Willer, Cristen J., Asvold, Bjorn Olav, Koellinger, Philipp D., Kaprio, Jaakko, Medland, Sarah E., Walters, Robin G., Benjamin, Daniel J., Turley, Patrick, Evans, David M., Smith, George Davey, Hayward, Caroline, Brumpton, Ben, Hemani, Gibran, Davies, Neil M., Howe, Laurence J., Nivard, Michel G., Morris, Tim T., Hansen, Ailin F., Rasheed, Humaira, Cho, Yoonsu, Chittoor, Geetha, Ahlskog, Rafael, Lind, Penelope A., Palviainen, Teemu, van der Zee, Matthijs D., Cheesman, Rosa, Mangino, Massimo, Wang, Yunzhang, Li, Shuai, Klaric, Lucija, Ratliff, Scott M., Bielak, Lawrence F., Nygaard, Marianne, Giannelis, Alexandros, Willoughby, Emily A., Reynolds, Chandra A., Balbona, Jared, Andreassen, Ole A., Ask, Helga, Baras, Aris, Bauer, Christopher R., Boomsma, Dorret, Campbell, Archie, Campbell, Harry, Chen, Zhengming, Christofidou, Paraskevi, Corfield, Elizabeth, Dahm, Christina C., Dokuru, Deepika R., Evans, Luke M., de Geus, Eco J. C., Giddaluru, Sudheer, Gordon, Scott D., Harden, K. Paige, Hill, W. David, Hughes, Amanda, Kerr, Shona M., Kim, Yongkang, Kweon, Hyeokmoon, Latvala, Antti, Lawlor, Deborah A., Li, Liming, Lin, Kuang, Magnus, Per, Magnusson, Patrik K. E., Mallard, Travis T., Martikainen, Pekka, Mills, Melinda C., Njolstad, Pal Rasmus, Overton, John D., Pedersen, Nancy L., Porteous, David J., Reid, Jeffrey, Silventoinen, Karri, Southey, Melissa C., Stoltenberg, Camilla, Tucker-Drob, Elliot M., Wright, Margaret J., Hewitt, John K., Keller, Matthew C., Stallings, Michael C., Lee, James J., Christensen, Kaare, Kardia, Sharon L. R., Peyser, Patricia A., Smith, Jennifer A., Wilson, James F., Hopper, John L., Hagg, Sara, Spector, Tim D., Pingault, Jean-Baptiste, Plomin, Robert, Havdahl, Alexandra, Bartels, Meike, Martin, Nicholas G., Oskarsson, Sven, Justice, Anne E., Millwood, Iona Y., Hveem, Kristian, Naess, Oyvind, Willer, Cristen J., Asvold, Bjorn Olav, Koellinger, Philipp D., Kaprio, Jaakko, Medland, Sarah E., Walters, Robin G., Benjamin, Daniel J., Turley, Patrick, Evans, David M., Smith, George Davey, Hayward, Caroline, Brumpton, Ben, Hemani, Gibran, and Davies, Neil M.
- Abstract
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic and indirect genetic effects, but large-scale family datasets have been lacking. We combined data from 178,086 siblings from 19 cohorts to generate population (between-family) and within-sibship (within-family) GWAS estimates for 25 phenotypes. Within-sibship GWAS estimates were smaller than population estimates for height, educational attainment, age at first birth, number of children, cognitive ability, depressive symptoms and smoking. Some differences were observed in downstream SNP heritability, genetic correlations and Mendelian randomization analyses. For example, the within-sibship genetic correlation between educational attainment and body mass index attenuated towards zero. In contrast, analyses of most molecular phenotypes (for example, low-density lipoprotein-cholesterol) were generally consistent. We also found within-sibship evidence of polygenic adaptation on taller height. Here, we illustrate the importance of family-based GWAS data for phenotypes influenced by demographic and indirect genetic effects. Within-sibship genome-wide association analyses using data from 178,076 siblings illustrate differences between population-based and within-sibship GWAS estimates for phenotypes influenced by demographic and indirect genetic effects.
- Published
- 2022
- Full Text
- View/download PDF
212. Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years
- Author
-
European Commission, National Institute of Child Health and Human Development (US), QIMR Berghofer Medical Research Institute (Australia), University of Queensland, National Cancer Institute (US), Dutch Research Council, Netherlands Organisation for Health Research and Development, National Institute of Mental Health (US), European Research Council, National Center for Advancing Translational Sciences (US), Medical Research Council (UK), Fundación Marques de Valdecilla, Instituto de Salud Carlos III, Swedish Research Council, South-Eastern Norway Regional Health Authority, Research Council of Norway, Icahn School of Medicine at Mount Sinai, South London and Maudsley NHS Foundation Trust, NHS Foundation Trust, National Institute for Health Research (UK), Frangou, Sophia, Modabbernia, Amirhossein, Williams, Steven C. R., Papachristou, Efstathios, Doucet, Gaelle E., Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Antón, Alnæs, Dag, Alpert, Kathryn I., Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H., Weber, Bernd, Bertolino, Alessandro, Wen, Wei, Kalnin, Andrew, West, John D., Westlye, Lars T., Whalley, Heather, Wierenga, Lara M., Wittfeld, Katharina, Wolf, Daniel H., Worker, Amanda, Wright, Margaret J., Yang, Kun, Bonvino, Aurora, Kanai, Ryota, Yoncheva, Yulyia, Zanetti, Marcus V., Ziegler, Georg C., Karolinska Schizophrenia Project, Thompson, Paul M., Dima, Danai, Boomsma, Dorret I., Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Klein, Marieke, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M., Buitelaar, Jan K., Busatto, Geraldo F., Buckner, Randy L., Calhoun, Vincent, Canales-Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier, Klyushnik, Tatyana P., Castellanos, Francisco X., Cervenka, Simon, Chaim-Avancini, Tiffany M., Ching, Christopher R. K., Chubar, Victoria, Clark, Vincent P., Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Koenders, Laura, Crone, Eveline A., Dale, Anders M., Dannlowski, Udo, Davey, Christopher, Geus, Eco J. C. de, Haan, Lieuwe de, Zubicaray, Greig I. de, den Braber, Anouk, Dickie, Erin W., Di Giorgio, Annabella, Koops, Sanne, Doan, Nhat Trung, Dørum, Erlend S., Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E., Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Krämer, Bernd, Fuentes-Claramonte, Paola, Glahn, David C., Gotlib, Ian H., Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E., Kuntsi, Jonna, Gur, Ruben C., Hahn, Tim, Harrison, Ben J., Hartman, Catharine A., Hatton, Sean N., Heinz, Andreas, Heslenfeld, Dirk J., Hibar, Derrek P., Hickie, Ian B., Ho, Beng-Choon, Lagopoulos, Jim, Hoekstra, Pieter J., Hohmann, Sarah, Holmes, Avram J., Hoogman, Martine, Hosten, Norbert, Howells, Fleur M., Hulshoff Pol, Hilleke E., Huyser, Chaim, Jahanshad, Neda, James, Anthony, Lázaro, Luisa, Jernigan, Terry L., Jiang, Jiyang, Jönsson, Erik G., Joska, John A., Kahn, René S., Andersson, Micael, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W. J., Maingault, Sophie, Martin, Nicholas G., Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, Andreasen, Nancy C., McDonald, Colm, McDonald, Brenna C., McIntosh, Andrew M., McMahon, Katie L., McPhilemy, Genevieve, Meinert, Susanne, Menchón, José M., Medland, Sarah E., Meyer-Lindenberg, Andreas, Naaijen, Jilly, Andreassen, Ole A., Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E., Nyberg, Lars, Oosterlaan, Jaap, Ortiz-Garcia de la Foz, Victor, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Asherson, Philip, Portella, Maria J., Potkin, Steven G., Radua, Joaquim, Reif, Andreas, Rinker, Daniel A., Roffman, Joshua L., Rosa, Pedro G. P., Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Banaschewski, Tobias, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D., Saykin, Andrew J., Serpa, Mauricio H., Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W., Bargalló, Núria, Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J., Strike, Lachlan T., Swagerman, Suzanne C., Tamnes, Christian K., Temmingh, Henk S., Thomopoulos, Sophia I., Tomyshev, Alexander S., Baumeister, Sarah, Tordesillas-Gutiérrez, Diana, Trollor, Julian N., Turner, Jessica A., Uhlmann, Anne, van den Heuvel, Odile A., van den Meer, Dennis, van der Wee, Nic J. A., van Haren, Neeltje E. M., van 't Ent, Dennis, van Erp, Theo G. M., Baur-Streubel, Ramona, Veer, Ilya M., Veltman, Dick J., European Commission, National Institute of Child Health and Human Development (US), QIMR Berghofer Medical Research Institute (Australia), University of Queensland, National Cancer Institute (US), Dutch Research Council, Netherlands Organisation for Health Research and Development, National Institute of Mental Health (US), European Research Council, National Center for Advancing Translational Sciences (US), Medical Research Council (UK), Fundación Marques de Valdecilla, Instituto de Salud Carlos III, Swedish Research Council, South-Eastern Norway Regional Health Authority, Research Council of Norway, Icahn School of Medicine at Mount Sinai, South London and Maudsley NHS Foundation Trust, NHS Foundation Trust, National Institute for Health Research (UK), Frangou, Sophia, Modabbernia, Amirhossein, Williams, Steven C. R., Papachristou, Efstathios, Doucet, Gaelle E., Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Antón, Alnæs, Dag, Alpert, Kathryn I., Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H., Weber, Bernd, Bertolino, Alessandro, Wen, Wei, Kalnin, Andrew, West, John D., Westlye, Lars T., Whalley, Heather, Wierenga, Lara M., Wittfeld, Katharina, Wolf, Daniel H., Worker, Amanda, Wright, Margaret J., Yang, Kun, Bonvino, Aurora, Kanai, Ryota, Yoncheva, Yulyia, Zanetti, Marcus V., Ziegler, Georg C., Karolinska Schizophrenia Project, Thompson, Paul M., Dima, Danai, Boomsma, Dorret I., Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Klein, Marieke, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M., Buitelaar, Jan K., Busatto, Geraldo F., Buckner, Randy L., Calhoun, Vincent, Canales-Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier, Klyushnik, Tatyana P., Castellanos, Francisco X., Cervenka, Simon, Chaim-Avancini, Tiffany M., Ching, Christopher R. K., Chubar, Victoria, Clark, Vincent P., Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Koenders, Laura, Crone, Eveline A., Dale, Anders M., Dannlowski, Udo, Davey, Christopher, Geus, Eco J. C. de, Haan, Lieuwe de, Zubicaray, Greig I. de, den Braber, Anouk, Dickie, Erin W., Di Giorgio, Annabella, Koops, Sanne, Doan, Nhat Trung, Dørum, Erlend S., Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E., Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Krämer, Bernd, Fuentes-Claramonte, Paola, Glahn, David C., Gotlib, Ian H., Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E., Kuntsi, Jonna, Gur, Ruben C., Hahn, Tim, Harrison, Ben J., Hartman, Catharine A., Hatton, Sean N., Heinz, Andreas, Heslenfeld, Dirk J., Hibar, Derrek P., Hickie, Ian B., Ho, Beng-Choon, Lagopoulos, Jim, Hoekstra, Pieter J., Hohmann, Sarah, Holmes, Avram J., Hoogman, Martine, Hosten, Norbert, Howells, Fleur M., Hulshoff Pol, Hilleke E., Huyser, Chaim, Jahanshad, Neda, James, Anthony, Lázaro, Luisa, Jernigan, Terry L., Jiang, Jiyang, Jönsson, Erik G., Joska, John A., Kahn, René S., Andersson, Micael, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W. J., Maingault, Sophie, Martin, Nicholas G., Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, Andreasen, Nancy C., McDonald, Colm, McDonald, Brenna C., McIntosh, Andrew M., McMahon, Katie L., McPhilemy, Genevieve, Meinert, Susanne, Menchón, José M., Medland, Sarah E., Meyer-Lindenberg, Andreas, Naaijen, Jilly, Andreassen, Ole A., Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E., Nyberg, Lars, Oosterlaan, Jaap, Ortiz-Garcia de la Foz, Victor, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Asherson, Philip, Portella, Maria J., Potkin, Steven G., Radua, Joaquim, Reif, Andreas, Rinker, Daniel A., Roffman, Joshua L., Rosa, Pedro G. P., Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Banaschewski, Tobias, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D., Saykin, Andrew J., Serpa, Mauricio H., Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W., Bargalló, Núria, Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J., Strike, Lachlan T., Swagerman, Suzanne C., Tamnes, Christian K., Temmingh, Henk S., Thomopoulos, Sophia I., Tomyshev, Alexander S., Baumeister, Sarah, Tordesillas-Gutiérrez, Diana, Trollor, Julian N., Turner, Jessica A., Uhlmann, Anne, van den Heuvel, Odile A., van den Meer, Dennis, van der Wee, Nic J. A., van Haren, Neeltje E. M., van 't Ent, Dennis, van Erp, Theo G. M., Baur-Streubel, Ramona, Veer, Ilya M., and Veltman, Dick J.
- Abstract
Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3–90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
- Published
- 2022
213. Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years
- Author
-
National Institute of Mental Health (US), Karolinska Institute, Stockholm County Council, South-Eastern Norway Regional Health Authority, German Centre for Cardiovascular Research, Siemens Healthcare, University of Queensland, Eunice Kennedy Shriver National Institute of Child Health and Human Development (US), National Health and Medical Research Council (Australia), National Institute on Drug Abuse (US), Indiana State Department of Health, Parents of children with epilepsy, Epilepsy Therapy Project, Fight Against Childhood Epilepsy and Seizures, Epilepsy Foundation, American Epilepsy Society, Knut and Alice Wallenberg Foundation, European Commission, Dutch Research Council, Netherlands Organization for Scientific Research, Netherlands Brain Foundation, Utrecht University, European Research Council, National Center for Advancing Translational Sciences (US), National Institutes of Health (US), National Center for Research Resources (US), Fundación Marques de Valdecilla, Instituto de Salud Carlos III, Swedish Research Council, Kings College London, South London and Maudsley NHS Foundation Trust, NIHR Biomedical Research Centre (UK), National Institute for Health Research (UK), Dima, Danai, Modabbernia, Amirhossein, Papachristou, Efstathios, Doucet, Gaelle E., Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Antón, Alnæs, Dag, Alpert, Kathryn I., Andersson, Micael, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A., Roffman, Joshua L., Rosa, Pedro G. P., Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Sánchez-Juan, Pascual, Tordesillas-Gutiérrez, Diana, Ehrlich, Stefan, Bargalló, Núria, Weber, Bernd, Sarró, Salvador, Satterthwaite, Theodore D., Saykin, Andrew J., Serpa, Mauricio H., Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Erk, Susanne, West, John D., Smoller, Jordan W., Sommer, Iris, Wen, Wei, Baumeister, Sarah, Hartman, Catharine A., Trollor, Julian N., Baur-Streubel, Ramona, Turner, Jessica A., Uhlmann, Anne, Espeseth, Thomas, van den Heuvel, Odile A., van den Meer, Dennis, van der Wee, Nic J. A., van Haren, Neeltje E. M., van't Ent, Dennis, van Erp, Theo G. M., Hatton, Sean N., Bonvino, Aurora, Veer, Ilya M., Veltman, Dick J., Fatouros-Bergman, Helena, Bertolino, Alessandro, Voineskos, Aristotle, Kanai, Ryota, Westlye, Lars T., Whalley, Heather, Wierenga, Lara M., Williams, Steven C. R., Heinz, Andreas, Wittfeld, Katharina, Wolf, Daniel H., Fisher, Simon E., Worker, Amanda, Wright, Margaret J., Yang, Kun, Yoncheva, Yulyia, Klein, Marieke, Boomsma, Dorret I., Zanetti, Marcus V., Ziegler, Georg C., Heslenfeld, Dirk J., Thompson, Paul M., Fouche, Jean-Paul, Frangou, Sophia, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Klyushnik, Tatyana P., Brouwer, Rachel M., Buitelaar, Jan K., Hibar, Derrek P., Franke, Barbara, Busatto, Geraldo F., Buckner, Randy L., Calhoun, Vincent, Canales-Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier, Castellanos, Francisco X., Cervenka, Simon, Koenders, Laura, Chaim-Avancini, Tiffany M., Frodl, Thomas, Hickie, Ian B., Ching, Christopher R. K., Chubar, Victoria, Clark, Vincent P., Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A., Dannlowski, Udo, Fuentes-Claramonte, Paola, Koops, Sanne, Ho, Beng-Choon, Dale, Anders M., Davey, Christopher, Geus, Eco J. C. de, de Haan, Lieuwe, Zubicaray, Greig I. de, den Braber, Anouk, Dickie, Erin W., Di Giorgio, Annabella, Hohmann, Sarah, Doan, Nhat Trung, Dørum, Erlend S., Hoekstra, Pieter J., Krämer, Bernd, Soriano-Mas, Carles, Glahn, David C., Kuntsi, Jonna, Gotlib, Ian H., Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E., Stein, Dan J., Lázaro, Luisa, Gur, Ruben C., Hahn, Tim, Lagopoulos, Jim, Harrison, Ben J., Völzke, Henry, Holmes, Avram J., Hoogman, Martine, Hosten, Norbert, Howells, Fleur M., Strike, Lachlan T., Hulshoff Pol, Hilleke E., Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L., Jiang, Jiyang, Walter, Henrik, Lebedeva, Irina, Jönsson, Erik G., Joska, John A., Swagerman, Suzanne C., Kahn, René S., Kalnin, Andrew, Andreasen, Nancy C., Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W. J., Walton, Esther, Maingault, Sophie, Martin, Nicholas G., Tamnes, Christian K., Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, Andreassen, Ole A., McDonald, Brenna C., McIntosh, Andrew M., McMahon, Katie L., Wang, Lei, McPhilemy, Genevieve, Temmingh, Henk S., Meinert, Susanne, Menchón, José M., Medland, Sarah E., Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Asherson, Philip, Nakao, Tomohiro, Nordvik, Jan E., Wang, Yang, Thomopoulos, Sophia I., Nyberg, Lars, Oosterlaan, Jaap, Ortiz-Garcia de la Foz, Victor, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J., Banaschewski, Tobias, Potkin, Steven G., Tomyshev, Alexander S., Wassink, Thomas H., National Institute of Mental Health (US), Karolinska Institute, Stockholm County Council, South-Eastern Norway Regional Health Authority, German Centre for Cardiovascular Research, Siemens Healthcare, University of Queensland, Eunice Kennedy Shriver National Institute of Child Health and Human Development (US), National Health and Medical Research Council (Australia), National Institute on Drug Abuse (US), Indiana State Department of Health, Parents of children with epilepsy, Epilepsy Therapy Project, Fight Against Childhood Epilepsy and Seizures, Epilepsy Foundation, American Epilepsy Society, Knut and Alice Wallenberg Foundation, European Commission, Dutch Research Council, Netherlands Organization for Scientific Research, Netherlands Brain Foundation, Utrecht University, European Research Council, National Center for Advancing Translational Sciences (US), National Institutes of Health (US), National Center for Research Resources (US), Fundación Marques de Valdecilla, Instituto de Salud Carlos III, Swedish Research Council, Kings College London, South London and Maudsley NHS Foundation Trust, NIHR Biomedical Research Centre (UK), National Institute for Health Research (UK), Dima, Danai, Modabbernia, Amirhossein, Papachristou, Efstathios, Doucet, Gaelle E., Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Antón, Alnæs, Dag, Alpert, Kathryn I., Andersson, Micael, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A., Roffman, Joshua L., Rosa, Pedro G. P., Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Sánchez-Juan, Pascual, Tordesillas-Gutiérrez, Diana, Ehrlich, Stefan, Bargalló, Núria, Weber, Bernd, Sarró, Salvador, Satterthwaite, Theodore D., Saykin, Andrew J., Serpa, Mauricio H., Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Erk, Susanne, West, John D., Smoller, Jordan W., Sommer, Iris, Wen, Wei, Baumeister, Sarah, Hartman, Catharine A., Trollor, Julian N., Baur-Streubel, Ramona, Turner, Jessica A., Uhlmann, Anne, Espeseth, Thomas, van den Heuvel, Odile A., van den Meer, Dennis, van der Wee, Nic J. A., van Haren, Neeltje E. M., van't Ent, Dennis, van Erp, Theo G. M., Hatton, Sean N., Bonvino, Aurora, Veer, Ilya M., Veltman, Dick J., Fatouros-Bergman, Helena, Bertolino, Alessandro, Voineskos, Aristotle, Kanai, Ryota, Westlye, Lars T., Whalley, Heather, Wierenga, Lara M., Williams, Steven C. R., Heinz, Andreas, Wittfeld, Katharina, Wolf, Daniel H., Fisher, Simon E., Worker, Amanda, Wright, Margaret J., Yang, Kun, Yoncheva, Yulyia, Klein, Marieke, Boomsma, Dorret I., Zanetti, Marcus V., Ziegler, Georg C., Heslenfeld, Dirk J., Thompson, Paul M., Fouche, Jean-Paul, Frangou, Sophia, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Klyushnik, Tatyana P., Brouwer, Rachel M., Buitelaar, Jan K., Hibar, Derrek P., Franke, Barbara, Busatto, Geraldo F., Buckner, Randy L., Calhoun, Vincent, Canales-Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier, Castellanos, Francisco X., Cervenka, Simon, Koenders, Laura, Chaim-Avancini, Tiffany M., Frodl, Thomas, Hickie, Ian B., Ching, Christopher R. K., Chubar, Victoria, Clark, Vincent P., Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A., Dannlowski, Udo, Fuentes-Claramonte, Paola, Koops, Sanne, Ho, Beng-Choon, Dale, Anders M., Davey, Christopher, Geus, Eco J. C. de, de Haan, Lieuwe, Zubicaray, Greig I. de, den Braber, Anouk, Dickie, Erin W., Di Giorgio, Annabella, Hohmann, Sarah, Doan, Nhat Trung, Dørum, Erlend S., Hoekstra, Pieter J., Krämer, Bernd, Soriano-Mas, Carles, Glahn, David C., Kuntsi, Jonna, Gotlib, Ian H., Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E., Stein, Dan J., Lázaro, Luisa, Gur, Ruben C., Hahn, Tim, Lagopoulos, Jim, Harrison, Ben J., Völzke, Henry, Holmes, Avram J., Hoogman, Martine, Hosten, Norbert, Howells, Fleur M., Strike, Lachlan T., Hulshoff Pol, Hilleke E., Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L., Jiang, Jiyang, Walter, Henrik, Lebedeva, Irina, Jönsson, Erik G., Joska, John A., Swagerman, Suzanne C., Kahn, René S., Kalnin, Andrew, Andreasen, Nancy C., Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W. J., Walton, Esther, Maingault, Sophie, Martin, Nicholas G., Tamnes, Christian K., Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, Andreassen, Ole A., McDonald, Brenna C., McIntosh, Andrew M., McMahon, Katie L., Wang, Lei, McPhilemy, Genevieve, Temmingh, Henk S., Meinert, Susanne, Menchón, José M., Medland, Sarah E., Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Asherson, Philip, Nakao, Tomohiro, Nordvik, Jan E., Wang, Yang, Thomopoulos, Sophia I., Nyberg, Lars, Oosterlaan, Jaap, Ortiz-Garcia de la Foz, Victor, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J., Banaschewski, Tobias, Potkin, Steven G., Tomyshev, Alexander S., and Wassink, Thomas H.
- Abstract
Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3–90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
- Published
- 2022
214. A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium
- Author
-
US Department of Veterans Affairs, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Swedish Research Council for Health, Working Life and Welfare, Fundação Amazônia de Amparo a Estudos e Pesquisas, Instituto de Salud Carlos III, National Health and Medical Research Council (Australia), National Institutes of Health (US), National Science Foundation (US), Research Council of Norway, Science Foundation Ireland, Wellcome Trust, Gutman, Boris A., van Erp, Theo G. M., Alpert, Kathryn I., Ching, Christopher R. K., Isaev, Dmitry, Ragothaman, Anjani, Jahanshad, Neda, Saremi, Arvin, Zavaliangos-Petropulu, Artemis, Glahn, David C., Shen, Li, Cong, Shan, Alnæs, Dag, Andreassen, Ole A., DoanNhat Trung, Westlye, Lars T., Kochunov, Peter, Satterthwaite, Theodore D., Wolf, Daniel H., Huang, Alexander J., Kessler, Charles, Weideman, Andrea, Nguyen, Dana, Mueller, Bryon A., Faziola, Lawrence, Potkin, Steven G., Preda Adrian, Mathalon, Daniel H., Bustillo Juan, Calhoun, Vincent, Ford, Judith M., Walton, Esther, Ehrlich, Stefan, Ducci, Giuseppe, Banaj, Nerisa, Piras, Fabrizio, Piras, Federica, Spalletta, Gianfranco, Canales-Rodríguez, Erick J., Fuentes-Claramonte, Paola, Pomarol-Clotet, Edith, Radua, Joaquim, Salvador, Raymond, Sarró, Salvador, Dickie, Erin W., Voineskos, Aristotle, Tordesillas-Gutiérrez, Diana, Crespo-Facorro, Benedicto, Setién-Suero, Esther, Mayoral-van Son, Jacqueline, Borgwardt, Stefan, Schönborn-Harrisberger, Fabienne, Morris, Derek, Donohoe, Gary, Holleran, Laurena, Cannon, Dara M., McDonald, Colm, Corvin, Aiden, Gill, Michael, Busatto, Geraldo F., Rosa, Pedro G. P., Serpa, Mauricio H., Zanetti, Marcus V., Lebedeva, Irina, Kaleda, Vasiliy G., Tomyshev, Alexander S., Crow, Tim, James, Anthony, Cervenka, Simon, Sellgren, Carl M., Fatouros-Bergman, Helena, Agartz, Ingrid, Howells, Fleur M., Stein, Dan J., Temmingh, Henk S., Uhlmann, Anne, Zubicaray, Greig I. de, McMahon, Katie L., Wright, Margaret J., Cobia, Derin, Csernansky, John G., Thompson, Paul M., Turner, Jessica A., Wang, Lei, US Department of Veterans Affairs, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Swedish Research Council for Health, Working Life and Welfare, Fundação Amazônia de Amparo a Estudos e Pesquisas, Instituto de Salud Carlos III, National Health and Medical Research Council (Australia), National Institutes of Health (US), National Science Foundation (US), Research Council of Norway, Science Foundation Ireland, Wellcome Trust, Gutman, Boris A., van Erp, Theo G. M., Alpert, Kathryn I., Ching, Christopher R. K., Isaev, Dmitry, Ragothaman, Anjani, Jahanshad, Neda, Saremi, Arvin, Zavaliangos-Petropulu, Artemis, Glahn, David C., Shen, Li, Cong, Shan, Alnæs, Dag, Andreassen, Ole A., DoanNhat Trung, Westlye, Lars T., Kochunov, Peter, Satterthwaite, Theodore D., Wolf, Daniel H., Huang, Alexander J., Kessler, Charles, Weideman, Andrea, Nguyen, Dana, Mueller, Bryon A., Faziola, Lawrence, Potkin, Steven G., Preda Adrian, Mathalon, Daniel H., Bustillo Juan, Calhoun, Vincent, Ford, Judith M., Walton, Esther, Ehrlich, Stefan, Ducci, Giuseppe, Banaj, Nerisa, Piras, Fabrizio, Piras, Federica, Spalletta, Gianfranco, Canales-Rodríguez, Erick J., Fuentes-Claramonte, Paola, Pomarol-Clotet, Edith, Radua, Joaquim, Salvador, Raymond, Sarró, Salvador, Dickie, Erin W., Voineskos, Aristotle, Tordesillas-Gutiérrez, Diana, Crespo-Facorro, Benedicto, Setién-Suero, Esther, Mayoral-van Son, Jacqueline, Borgwardt, Stefan, Schönborn-Harrisberger, Fabienne, Morris, Derek, Donohoe, Gary, Holleran, Laurena, Cannon, Dara M., McDonald, Colm, Corvin, Aiden, Gill, Michael, Busatto, Geraldo F., Rosa, Pedro G. P., Serpa, Mauricio H., Zanetti, Marcus V., Lebedeva, Irina, Kaleda, Vasiliy G., Tomyshev, Alexander S., Crow, Tim, James, Anthony, Cervenka, Simon, Sellgren, Carl M., Fatouros-Bergman, Helena, Agartz, Ingrid, Howells, Fleur M., Stein, Dan J., Temmingh, Henk S., Uhlmann, Anne, Zubicaray, Greig I. de, McMahon, Katie L., Wright, Margaret J., Cobia, Derin, Csernansky, John G., Thompson, Paul M., Turner, Jessica A., and Wang, Lei
- Abstract
Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more-convex-than-concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta-analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia.
- Published
- 2022
215. Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group
- Author
-
Brouwer, Rachel M., Panizzon, Matthew S., Glahn, David C., Hibar, Derrek P., Hua, Xue, Jahanshad, Neda, Abramovic, Lucija, de Zubicaray, Greig I., Franz, Carol E., Hansell, Narelle K., Hickie, Ian B., Koenis, Marinka M.G., Martin, Nicholas G., Mather, Karen A., McMahon, Katie L., Schnack, Hugo G., Strike, Lachlan T., Swagerman, Suzanne C., Thalamuthu, Anbupalam, Wen, Wei, Gilmore, John H., Gogtay, Nitin, Kahn, René S., Sachdev, Perminder S., Wright, Margaret J., Boomsma, Dorret I., Kremen, William S., Thompson, Paul M., and Hulshoff Pol, Hilleke E.
- Published
- 2017
- Full Text
- View/download PDF
216. Using Padlet in a Science classroom
- Author
-
Wright, Margaret
- Published
- 2017
217. SNP Sets and Reading Ability: Testing Confirmation of a 10-SNP Set in a Population Sample
- Author
-
Luciano, Michelle, Montgomery, Grant W, Martin, Nicholas G, Wright, Margaret J, and Bates, Timothy C
- Published
- 2011
218. Multidimensional Assessment of Resilience in Mothers Who Are Child Sexual Abuse Survivors
- Author
-
Wright, Margaret O'Dougherty, Fopma-Loy, Joan, and Fischer, Stephanie
- Abstract
Objective: There has been relatively little attention given to positive adaptation following childhood sexual abuse (CSA), and typically such resilience has been explored primarily in the intrapersonal domain. This study explored questions about later resilience following CSA within a multidimensional framework by assessing resilience across intrapersonal, interpersonal, and intrafamilial domains. Method: This community sample consisted of 79 mothers with a history of CSA who had a child living at home with them. Participants completed four outcome measures (Center for Epidemiologic Studies--Depression Scale, Parenting Stress Index [PSI] Health Scale, PSI Parenting Competence Scale, and a measure of marital satisfaction). Risk and protective factors examined in relation to outcome included mother's age, socioeconomic status, severity of the CSA experience, coping strategy (avoidance, seeking social support, and problem solving), child characteristics, and spousal/partner support. Results: Results indicated that when multiple adaptational domains were assessed, mothers showed discrepancies in how adequately they functioned across domains. While severity of the CSA experience was only weakly associated with outcome, use of avoidant coping emerged as a significant risk factor and was strongly and consistently associated with negative outcome across domains. Spousal/partner support was a strong protective factor and buffered the relationship between depressive symptoms and parenting competence. Difficult child characteristics were significantly associated with mothers' perceptions of physical health and parenting competence. Conclusions: The findings suggest the importance of comprehensive multimethod assessments of resilience and extend the knowledge of factors associated with positive outcome. The results highlight the need for further research exploring current contextual risk and protective factors associated with resilience in each domain.
- Published
- 2005
- Full Text
- View/download PDF
219. Motivation and the Adult Irish Language Learner
- Author
-
Wright, Margaret and McGrory, Orla
- Abstract
What motivates adult language learners in the city of Belfast to enrol and remain in an Irish class in the first years of the twenty-first century is the subject of the research study reported here. The research is placed within the context of the long history of interest in Irish revival in the city as far back as the eighteenth century and is related to relevant literature on motivation and language learning. The paper provides results from quantitative data collected by means of questionnaires issued to learners throughout the city. An overwhelming interest in culture is what primarily motivates these learners to enrol in an Irish class. Learners are also motivated by a strong sense of identity and by a felt obligation to help preserve the language. The paper illuminates issues of language restoration and the links between identity and language preservation. The research reported here contributes to the literatures on motivation, on adult learning and on language survival.
- Published
- 2005
220. The Impact of Religiosity on Adolescent Sexual Behavior: A Review of the Evidence
- Author
-
Rostosky, Sharon Scales, Wilcox, Brian L., and Wright, Margaret Laurie Comer
- Abstract
Longitudinal studies published between 1980 and 2001 (N = 10) are reviewed for evidence that the religiosity of adolescents is causally related to their sexual behaviors. Results indicate that religiosity delays the sexual debut of adolescent females. Findings are mixed for adolescent males. Although only half of the studies examined the effects of race and ethnicity, results of these studies reported similar effects for White and Black adolescents. These findings are discussed in light of their implications for researchers, educators, policy makers, and others concerned with adolescent sexual health and well-being.
- Published
- 2004
- Full Text
- View/download PDF
221. Heritability of Head Size in Dutch and Australian Twin Families at Ages 0-50 Years
- Author
-
Smit, Dirk JA, Luciano, Michelle, Bartels, Meike, van Beijsterveldt, Catharine EM, Wright, Margaret J, Hansell, Narelle K, Brunner, Han G, Estourgie-van Burk, GFrederiek, de Geus, Eco JC, Martin, Nicholas G, and Boomsma, Dorret I
- Published
- 2010
222. Sex Differences in the Genetic Architecture of Optimism and Health and Their Interrelation: A Study of Australian and Swedish Twins
- Author
-
Mosing, Miriam, Pedersen, Nancy L, Martin, Nicholas G, and Wright, Margaret J
- Published
- 2010
223. Genome-wide Association Study of Height and Body Mass Index in Australian Twin Families
- Author
-
Liu, Jimmy Z, Medland, Sarah E, Wright, Margaret J, Henders, Anjali K, Heath, Andrew C, Madden, Pamela AF, Duncan, Alexis, Montgomery, Grant W, Martin, Nicholas G, and McRae, Allan F
- Published
- 2010
224. Genetics and Brain Morphology
- Author
-
Strike, Lachlan T., Couvy-Duchesne, Baptiste, Hansell, Narelle K., Cuellar-Partida, Gabriel, Medland, Sarah E., and Wright, Margaret J.
- Published
- 2015
- Full Text
- View/download PDF
225. Brain structure in healthy adults is related to serum transferrin and the H63D polymorphism in the HFE gene
- Author
-
Jahanshad, Neda, Kohannim, Omid, Hibar, Derrek P., Stein, Jason L., McMahon, Katie L., de Zubicaray, Greig I., Medland, Sarah E., Montgomery, Grant W., Whitfield, John B., Martin, Nicholas G., Wright, Margaret J., Toga, Arthur W., and Thompson, Paul M.
- Published
- 2012
226. The heritability of brain metabolites on proton magnetic resonance spectroscopy in older individuals
- Author
-
Batouli, Seyed Amir Hossein, Sachdev, Perminder S., Wen, Wei, Wright, Margaret J., Suo, Chao, Ames, David, and Trollor, Julian N.
- Published
- 2012
- Full Text
- View/download PDF
227. Genome-Wide Association Study Identifies Three Common Variants Associated with Serologic Response to Vitamin E Supplementation in Men1–4
- Author
-
Major, Jacqueline M., Yu, Kai, Chung, Charles C., Weinstein, Stephanie J., Yeager, Meredith, Wheeler, William, Snyder, Kirk, Wright, Margaret E., Virtamo, Jarmo, Chanock, Stephen, and Albanes, Demetrius
- Published
- 2012
- Full Text
- View/download PDF
228. Hierarchical topological network analysis of anatomical human brain connectivity and differences related to sex and kinship
- Author
-
Duarte-Carvajalino, Julio M., Jahanshad, Neda, Lenglet, Christophe, McMahon, Katie L., de Zubicaray, Greig I., Martin, Nicholas G., Wright, Margaret J., Thompson, Paul M., and Sapiro, Guillermo
- Published
- 2012
- Full Text
- View/download PDF
229. Persistence of Anxiety/Depression Symptoms in Early Adolescence: A Prospective Study of Daily Life Stress, Rumination, and Daytime Sleepiness in a Genetically Informative Cohort
- Author
-
Hansell, Narelle K., primary, Strike, Lachlan T., additional, de Zubicaray, Greig I., additional, Thompson, Paul M., additional, McMahon, Katie L., additional, and Wright, Margaret J., additional
- Published
- 2022
- Full Text
- View/download PDF
230. Nature Versus Nurture – Studying the Relationships Between Diet and Depression in Older Adults
- Author
-
Matison, Annabel, primary, Thalamuthu, Anbupalam, additional, Reppermund, Simone, additional, Flood, Victoria, additional, Trollor, Julian, additional, Wright, Margaret, additional, Ames, David, additional, Brodaty, Henry, additional, Sachdev, Perminder, additional, and Mather, Karen, additional
- Published
- 2022
- Full Text
- View/download PDF
231. Genetic Specificity of Hippocampal Subfield Volumes, Relative to Hippocampal Formation, Identified in 2148 Young Adult Twins and Siblings
- Author
-
Hansell, Narelle K., primary, Strike, Lachlan T., additional, van Eijk, Liza, additional, O’Callaghan, Victoria, additional, Martin, Nicholas G., additional, de Zubicaray, Greig I., additional, Thompson, Paul M., additional, McMahon, Katie L., additional, and Wright, Margaret J., additional
- Published
- 2022
- Full Text
- View/download PDF
232. Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages
- Author
-
Modabbernia, Amirhossein, primary, Vidal-Pineiro, Didac, additional, Agartz, Ingrid, additional, Andreassen, Ole, additional, Ayesa-Arriola, Rosa, additional, Bertolino, Alessandro, additional, Boomsma, D, additional, Bourque, Josiane, additional, Breier, Alan, additional, Brodaty, Henry, additional, Brouwer, Rachel, additional, Buitelaar, Jan, additional, Canales-Rodriguez, Erick, additional, Caseras, Xavier, additional, Conrod, Patricia, additional, Crespo-Facorro, Benedicto, additional, Crivello, Fabrice, additional, Crone, Eveline, additional, De Zubicaray, Greig, additional, Dickie, Erin, additional, Dima, Danai, additional, Espeseth, Thomas, additional, Frenzel, Stefan, additional, Fisher, Simon, additional, Franke, Barbara, additional, Glahn, David, additional, Grabe, Hans, additional, Grotegerd, Dominik, additional, Gruber, Oliver, additional, Guerrero-Pedraza, Amalia, additional, Gur, Raquel, additional, Gur, Ruben, additional, Hartman, Catharina, additional, Hoekstra, Pieter, additional, Pol, Hilleke Hulshoff, additional, Jahanshad, Neda, additional, Jernigan, Terry, additional, Jiang, Jiyang, additional, Kalnin, Andrew, additional, Kochan, Nicole, additional, Mazoyer, Bernard, additional, McDonald, Brenna, additional, McMahon, Katie, additional, Nyberg, Lars, additional, Oosterlaan, Jaap, additional, Pomarol-Clotet, E, additional, Radua, Joaquim, additional, Roffman, Joshua, additional, Sachdev, Perminder, additional, Satterthwaite, Theodore, additional, Salvador, Raymond, additional, Sarró, Salvador, additional, Saykin, Andrew, additional, Schumann, Gunter, additional, Smoller, Jordan, additional, Sommer, Iris, additional, Tamnes, Christian, additional, Thomopoulos, Sophia, additional, Trollor, Julian, additional, Ent, Dennis van 't, additional, Voineskos, Aristotle, additional, Wang, Yang, additional, Weber, Bernd, additional, Wen, Wei, additional, Westlye, Lars T., additional, Whalley, Heather, additional, wierenga, Lara, additional, Williams, Steven, additional, Wittfeld, Katharina, additional, Wright, Margaret, additional, Thompson, Paul, additional, Paus, Tomas, additional, and Frangou, Sophia, additional
- Published
- 2022
- Full Text
- View/download PDF
233. ErbB Signaling Pathway Genes Are Differentially Expressed in Monozygotic Twins Discordant for Sports-Related Concussion
- Author
-
Stahl, Tyler J., primary, Palli, Rohith, additional, Gill, Jessica M., additional, Saionz, Elizabeth L., additional, Bogner-Flatz, Viktoria, additional, Cheetham-West, Arokoruba, additional, Merchant-Borna, Kian, additional, Pham, Dzung L., additional, Strike, Lachlan, additional, Wright, Margaret J., additional, Thompson, Paul, additional, and Bazarian, Jeffrey J., additional
- Published
- 2022
- Full Text
- View/download PDF
234. The Queensland Twin Adolescent Brain Project, a longitudinal study of adolescent brain development
- Author
-
Strike, Lachlan T., primary, Hansell, Narelle K., additional, Chuang, Kai-Hsiang, additional, Miller, Jessica L., additional, de Zubicaray, Greig I., additional, Thompson, Paul M., additional, McMahon, Katie L., additional, and Wright, Margaret J., additional
- Published
- 2022
- Full Text
- View/download PDF
235. SCN1A overexpression, associated with a genomic region marked by a risk variant for a common epilepsy, raises seizure susceptibility
- Author
-
Silvennoinen, Katri, primary, Gawel, Kinga, additional, Tsortouktzidis, Despina, additional, Pitsch, Julika, additional, Alhusaini, Saud, additional, van Loo, Karen M. J., additional, Picardo, Richard, additional, Michalak, Zuzanna, additional, Pagni, Susanna, additional, Martins Custodio, Helena, additional, Mills, James, additional, Whelan, Christopher D., additional, de Zubicaray, Greig I., additional, McMahon, Katie L., additional, van der Ent, Wietske, additional, Kirstein-Smardzewska, Karolina J., additional, Tiraboschi, Ettore, additional, Mudge, Jonathan M., additional, Frankish, Adam, additional, Thom, Maria, additional, Wright, Margaret J., additional, Thompson, Paul M., additional, Schoch, Susanne, additional, Becker, Albert J., additional, Esguerra, Camila V., additional, and Sisodiya, Sanjay M., additional
- Published
- 2022
- Full Text
- View/download PDF
236. Creating a Safe Haven Following Child Maltreatment : The Benefits and Limits of Social Support
- Author
-
Wright, Margaret O’Dougherty, primary and Folger, Susan F., additional
- Published
- 2016
- Full Text
- View/download PDF
237. Genetic imaging consortium for addiction medicine
- Author
-
Mackey, Scott, primary, Kan, Kees-Jan, additional, Chaarani, Bader, additional, Alia-Klein, Nelly, additional, Batalla, Albert, additional, Brooks, Samantha, additional, Cousijn, Janna, additional, Dagher, Alain, additional, de Ruiter, Michiel, additional, Desrivieres, Sylvane, additional, Feldstein Ewing, Sarah W., additional, Goldstein, Rita Z., additional, Goudriaan, Anna E., additional, Heitzeg, Mary M., additional, Hutchison, Kent, additional, Li, Chiang-Shan R., additional, London, Edythe D., additional, Lorenzetti, Valentina, additional, Luijten, Maartje, additional, Martin-Santos, Rocio, additional, Morales, Angelica M., additional, Paulus, Martin P., additional, Paus, Tomas, additional, Pearlson, Godfrey, additional, Schluter, Renée, additional, Momenan, Reza, additional, Schmaal, Lianne, additional, Schumann, Gunter, additional, Sinha, Rajita, additional, Sjoerds, Zsuzsika, additional, Stein, Dan J., additional, Stein, Elliot A., additional, Solowij, Nadia, additional, Tapert, Susan, additional, Uhlmann, Anne, additional, Veltman, Dick, additional, van Holst, Ruth, additional, Walter, Henrik, additional, Wright, Margaret J., additional, Yucel, Murat, additional, Yurgelun-Todd, Deborah, additional, Hibar, Derrek P., additional, Jahanshad, Neda, additional, Thompson, Paul M., additional, Glahn, David C., additional, Garavan, Hugh, additional, and Conrod, Patricia, additional
- Published
- 2016
- Full Text
- View/download PDF
238. A Comprehensive Neuropsychiatric Study of Elderly Twins: The Older Australian Twins Study
- Author
-
OATS Research Team, Sachdev, Perminder s, Lammel, Andrea, Trollor, Julian N, Lee, Teresa, Wright, Margaret J, Ames, David, Wen, Wei, Martin, Nicholas G, Brodaty, Henry, and Schofield, Peter R
- Published
- 2009
239. Experiences and Beliefs as Predictors of Ethnic Identity and Intergroup Relations.
- Author
-
Wright, Margaret O'Dougherty and Littleford, Linh Nguyen
- Abstract
Factors affecting ethnic identity and other group orientation were assessed in 115 college students from 5 ethnic groups. Ethnic group self-identification, negative and positive interracial experiences, perceptions of racial bias, social support, just-world beliefs, and psychological distress were each associated with various components of ethnic identity and are discussed within a counseling perspective. (Contains 39 references and 4 tables.) (Author)
- Published
- 2002
240. A Primal-dual Interior Method for Nonconvex Nonlinear Programming
- Author
-
Gay, David M., Overton, Michael L., Wright, Margaret H., Pardalos, Panos M., editor, Hearn, Donald, editor, and Yuan, Ya-xiang, editor
- Published
- 1998
- Full Text
- View/download PDF
241. The interior-point revolution in constrained optimization
- Author
-
Wright, Margaret H., Pardalos, Panos M., editor, Hearn, Donald, editor, De Leone, Renato, editor, Murli, Almerico, editor, and Toraldo, Gerardo, editor
- Published
- 1998
- Full Text
- View/download PDF
242. A Genetic Basis for Social Trust?
- Author
-
Sturgis, Patrick, Read, Sanna, Hatemi, Peter K., Zhu, Gu, Trull, Tim, Wright, Margaret J., and Martin, Nicholas G.
- Published
- 2010
243. Genetic Covariation among Facets of Openness to Experience and General Cognitive Ability
- Author
-
Wainwright, Mark A, Wright, Margaret J, Luciano, Michelle, Geffen, Gina M, and Martin, Nicholas G
- Published
- 2008
244. Genetic Contribution to Individual Variation in Binocular Rivalry Rate
- Author
-
Miller, Steven M., Hansell, Narelle K., Ngo, Trung T., Liu, Guang B., Pettigrew, John D., Martin, Nicholas G., Wright, Margaret J., and Purves, Dale
- Published
- 2010
- Full Text
- View/download PDF
245. On the Heritability of Inspection Time and Its Covariance with IQ: A Twin Study.
- Author
-
Luciano, Michelle, Smith, Glen A., Wright, Margaret J., Geffen, Gina M., Geffen, Laurie B., and Martin, Nicholas G.
- Abstract
Used the classical twin design with 390 pairs of twins to study the influence of genetic factors on the large phenotypic variation in inspection time (IT) and whether the well-established IT-IQ association could be explained by a common genetic factor. Findings provide potentially important information for the biological bases of the information-processing-IQ relationship. (SLD)
- Published
- 2001
246. Wilde's 'Puritanism': Hester Worsley and the American Dream
- Author
-
WRIGHT, MARGARET
- Published
- 2009
- Full Text
- View/download PDF
247. Heritability of NEO PI-R Extraversion Facets and their Relationship with IQ
- Author
-
Pincombe, Jennifer L, Luciano, Michelle, Martin, Nicholas G, and Wright, Margaret J
- Published
- 2007
248. Genetic Influence on the Variance in Coincidence Timing and Its Covariance with IQ: A Twin Study.
- Author
-
Wright, Margaret J., Smith, Glen A., Geffen, Gina M., Geffen, Laurie B., and Martin, Nicholas G.
- Abstract
Studied whether genetic variability explained some of the variance in coincidence timing and whether common genetic factors accounted for the association with intellectual functioning using 55 pairs of 16-year-old twins. Results suggest that the genetic influence operating on coincidence timing skills was of similar magnitude to that of response time tasks. Discusses implications for the study of shared variance among different information processing measures. (SLD)
- Published
- 2000
249. Using appreciative inquiry to initiate a managed clinical network for children's liver disease in the UK
- Author
-
Baker, Alastair and Wright, Margaret
- Published
- 2006
- Full Text
- View/download PDF
250. Handedness in Twins: Joint Analysis of Data from 35 Samples
- Author
-
Medland, Sarah E, Duffy, David L, Wright, Margaret J, Geffen, Gina M, and Martin, Nicholas G
- Published
- 2006
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.