212 results on '"Wu, Guolin"'
Search Results
202. Ixazomib-based frontline therapy in patients with newly diagnosed multiple myeloma in real-life practice showed comparable efficacy and safety profile with those reported in clinical trial: a multi-center study.
- Author
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Li J, Bao L, Xia Z, Wang S, Zhou X, Ding K, Zhang W, Yang W, Li B, Fu C, Chen B, Hua L, Wang L, Luo J, Yang Y, Xu T, Wang W, Huang Y, Wu G, and Liu P
- Subjects
- Adolescent, Adult, Aged, Antibodies, Monoclonal administration & dosage, Antibodies, Monoclonal adverse effects, Antineoplastic Combined Chemotherapy Protocols adverse effects, Boron Compounds adverse effects, Cyclophosphamide administration & dosage, Cyclophosphamide adverse effects, Dexamethasone administration & dosage, Dexamethasone adverse effects, Doxorubicin administration & dosage, Doxorubicin adverse effects, Drug Administration Schedule, Female, Glycine administration & dosage, Glycine adverse effects, Humans, Lenalidomide administration & dosage, Lenalidomide adverse effects, Male, Middle Aged, Multiple Myeloma mortality, Multiple Myeloma pathology, Neoplasm Staging, Peripheral Nervous System Diseases diagnosis, Peripheral Nervous System Diseases physiopathology, Remission Induction, Survival Analysis, Thalidomide administration & dosage, Thalidomide adverse effects, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Boron Compounds administration & dosage, Glycine analogs & derivatives, Multiple Myeloma drug therapy, Peripheral Nervous System Diseases chemically induced
- Abstract
The induction therapy containing ixazomib, an oral proteasome inhibitor, has shown favorable efficacy and safety in clinical trials, but its experience in real-life remains limited. In routine practice, few patients received ixazomib-based induction therapy due to reasons including (1) patients' preference on oral regimens, (2) concerns on adverse events (AEs) of other intravenous/subcutaneous regimens, (3) requirements for less center visits, and (4) fears of COVID-19 and other infectious disease exposures. With the aim of assessing the real-life effectiveness and safety of ixazomib-based induction therapy, we performed this multi-center, observational study on 85 newly diagnosed multiple myeloma (NDMM) patients from 14 medical centers. Ixazomib-based regimens included ixazomib-lenalidomide-dexamethasone (IRd) in 44.7% of patients, ixazomib-dexamethasone (Id) in 29.4%, and Id plus another agent (doxorubicin, cyclophosphamide, thalidomide, or daratumumab) in 25.9%. Different ixazomib-based therapies were applied due to (1) financial burdens or limitations on local health insurance coverage, (2) concerns on treatment tolerance, and (3) drug accessibility issue. Ten patients received ixazomib maintenance. The median age was 67 years; 43.5% had ISS stage III disease; 48.2% had an Eastern Cooperative Oncology Group performance score ≥ 2; and 17.6% with high-risk cytogenetic abnormalities. Overall response rate for all 85 patients was 95.3%, including 65.9% very good partial response or better and 29.5% complete responses. The median time to response was 30 days. The response rate was similar across different ixazomib-based regimens. Median progression-free survival was not reached. Severe AEs (≥ grade 3) were reported in 29.4% of patients. No grade 3/4 peripheral neuropathy (PN) occurred. Patients received a median of 6 (range 1-20) cycles of ixazomib treatment; 56.6% remained on treatment at data cutoff; 15.3% discontinued treatment due to intolerable AEs. These results support that the ixazomib-based frontline therapy was highly effective with acceptable toxicity in routine practice and the ixazomib oral regimens could be good alternative options for NDMM patients.
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- 2020
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203. Retrospective Analysis of Chinese Patients with Hepatocellular Carcinoma (HCC) undergoing Transcatheter Arterial Chemoembolization (TACE) with or without Prophylactic Antibiotic Therapy.
- Author
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Chen J and Wu G
- Subjects
- Aged, China, Female, Humans, Male, Middle Aged, Retrospective Studies, Anti-Bacterial Agents therapeutic use, Antibiotic Prophylaxis, Carcinoma, Hepatocellular therapy, Chemoembolization, Therapeutic, Liver Neoplasms therapy
- Abstract
Objective: To assess the necessity of prophylactic antibiotic therapy in HCC patients undergoing transcatheter arterial chemoembolization (TACE)., Study Design: Descriptive study., Place and Duration of Study: The First Affliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China, from August 2016 to August 2017., Methodology: Retrospective TACE-treated cases were analysed in this study. The basic characteristics of the patients,the days in hospital, the laboratory data and fever after the procedure were assessed and compared. A review of literature of published studies and our present study were further conducted to determine the necessity of prophylactic antibiotic therapy., Results: In 159 cases, there were no significant difference in the leukocyte count (p=0.552), neutrophil count (p=0.573) and fever (p=0.31) with and without prophylactic antibiotic therapy groups. The hospital stay was significantly increased in the prophylactic antibiotic group (p<0.001). The fever of previous and the present results showed no significant difference (p=0.25) between the groups., Conclusion: Prophylactic antibiotic therapy is not routinely necessary in the procedure of TACE for HCC patients.
- Published
- 2018
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204. Synthesis and structure-activity relationship studies of MI-2 analogues as MALT1 inhibitors.
- Author
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Wu G, Wang H, Zhou W, Zeng B, Mo W, Zhu K, Liu R, Zhou J, Chen C, and Chen H
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- Cell Line, Tumor, Cell Proliferation drug effects, Drug Design, Enzyme Inhibitors chemistry, Enzyme Inhibitors pharmacology, Humans, Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein metabolism, Structure-Activity Relationship, Triazoles chemical synthesis, Triazoles pharmacology, Enzyme Inhibitors chemical synthesis, Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein antagonists & inhibitors, Triazoles chemistry
- Abstract
Recent studies revealed that MALT1 is a promising therapeutic target for the treatment of ABC-DLBCL. Among several reported MALT1 inhibitors, MI-2 as an irreversible inhibitor represents a new class of ABC-DLBCL therapeutics. Due to its inherent potential cross-reactivity, further structure-activity relationship (SAR) study is imperative. In this work, five focused compound libraries based on the chemical structure of MI-2 are designed and synthesized. The systematic SARs revealed that the side chain of 2-methoxyethoxy has little impact on the activity and can be replaced by other functionalized groups, providing new MI-2 analogues with retained or enhanced potency. Compounds 81-83 with terminal hydroxyl group as side chain displayed enhanced activities against MALT1. Replacement of triazole core with pyrazole is also tolerant, while structural modifications on other sites are detrimental. These findings will facilitate further development of small-molecule MALT1 inhibitors., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
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- 2018
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205. Expression of β-adrenergic receptor subtypes in human normal and dilated ureter.
- Author
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Shen H, Chen Z, Mokhtar AD, Bi X, Wu G, Gong S, Huang C, Li S, and Du S
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- Aged, Dilatation, Pathologic genetics, Dilatation, Pathologic metabolism, Down-Regulation, Female, Humans, Male, Middle Aged, RNA, Messenger metabolism, Receptors, Adrenergic, beta-1 genetics, Receptors, Adrenergic, beta-1 metabolism, Receptors, Adrenergic, beta-2 genetics, Receptors, Adrenergic, beta-2 metabolism, Receptors, Adrenergic, beta-3 genetics, Receptors, Adrenergic, beta-3 metabolism, Ureter physiology, Mucous Membrane metabolism, Muscle, Smooth metabolism, Receptors, Adrenergic, beta genetics, Receptors, Adrenergic, beta metabolism, Ureter metabolism, Ureter pathology
- Abstract
Background: Ureter peristalsis is a basic physiological function regulated by myogenic and neurogenic factors. The distribution and function of β-adrenergic receptors (β-AR) in the human ureter remain unknown. The aim of this study was to investigate the expression of β-AR subtypes in the normal and dilated human ureter., Methods: The upper, middle, and lower segments of normal and dilated ureters were collected from patients undergoing surgery for carcinoma of the kidney and upper urinary tract and ureteral stenosis. The mucosa and muscular layers were separated. Expression of β1-AR, β2-AR, and β3-AR mRNA and protein levels were detected by real-time PCR, western blot, and immunohistochemistry., Results: In both mucosa and muscular layers, the mRNA and protein expressions of β1-AR, β2-AR, and β3-AR were lower in the dilated ureter compared with the normal ureter. β1-AR mRNA was significantly decreased (by 76.64%; P < 0.01) in the mucosa layer of the middle segment of the dilated ureter. β1-AR and β3-AR mRNA were significantly decreased (by 75.53 and 53.62%, respectively; P < 0.01) in the muscular layer of the lower segment of the dilated ureter. Similar findings were observed for protein expression., Conclusions: The downregulation of β-ARs after ureter dilation, particularly for β1-AR and β3-AR in the muscular layer, suggests a potential compensatory mechanism involving increased contraction of the ureter to push urine through the obstruction. Thus, β-ARs may be a potential target for treatment of ureter obstruction.
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- 2017
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206. PAX5 interacts with RIP2 to promote NF-κB activation and drug-resistance in B-lymphoproliferative disorders.
- Author
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Wang D, Chen J, Li R, Wu G, Sun Z, Wang Z, Zhai Z, Fang F, Guo Y, Zhong Y, Jiang M, Xu H, Chen M, Shen G, Sun J, Yan B, Yu C, Tian Z, and Xiao W
- Subjects
- Antineoplastic Agents pharmacology, Antineoplastic Agents therapeutic use, B-Lymphocytes drug effects, Bortezomib pharmacology, Bortezomib therapeutic use, Carcinogenesis metabolism, Carcinogenesis pathology, Cell Line, Tumor, Cell Proliferation drug effects, Humans, Lymphoproliferative Disorders pathology, Models, Biological, Nod Signaling Adaptor Proteins metabolism, Protein Binding drug effects, Signal Transduction drug effects, Tumor Necrosis Factor-alpha pharmacology, B-Lymphocytes metabolism, Drug Resistance, Neoplasm drug effects, Lymphoproliferative Disorders metabolism, NF-kappa B metabolism, PAX5 Transcription Factor metabolism, Receptor-Interacting Protein Serine-Threonine Kinase 2 metabolism
- Abstract
Paired box protein 5 (PAX5) plays a lineage determination role in B-cell development. However, high expression of PAX5 has been also found in various malignant diseases, including B-lymphoproliferative disorders (B-LPDs), but its functions and mechanisms in these diseases are still unclear. Here, we show that PAX5 induces drug resistance through association and activation of receptor-interacting serine/threonine-protein kinase 2 (RIP2; also known as RIPK2), and subsequent activation of NF-κB signaling and anti-apoptosis gene expression in B-lymphoproliferative cells. Furthermore, PAX5 is able to interact with RIP1 and RIP3, modulating both RIP1-mediated TNFR and RIP2-mediated NOD1 and NOD2 pathways. Our findings describe a new function of PAX5 in regulating RIP1 and RIP2 activation, which is at least involved in chemotherapeutic drug resistance in B-LPDs., (© 2016. Published by The Company of Biologists Ltd.)
- Published
- 2016
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207. Catalyst-controlled highly selective coupling and oxygenation of olefins: a direct approach to alcohols, ketones, and diketones.
- Author
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Su Y, Sun X, Wu G, and Jiao N
- Subjects
- Catalysis, Free Radicals chemistry, Iodine chemistry, Alcohols chemistry, Alkenes chemistry, Ketones chemistry, Oxygen chemistry
- Published
- 2013
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208. Magnetic and pH-sensitive nanoparticles for antitumor drug delivery.
- Author
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Yu S, Wu G, Gu X, Wang J, Wang Y, Gao H, and Ma J
- Subjects
- Cell Line, Tumor, Humans, Hydrogen-Ion Concentration drug effects, Nanoparticles ultrastructure, Particle Size, Polymers chemical synthesis, Polymers chemistry, Silicon Dioxide chemistry, Solutions, Spectroscopy, Fourier Transform Infrared, Static Electricity, Thermogravimetry, Antineoplastic Agents pharmacology, Doxorubicin pharmacology, Drug Delivery Systems, Magnetic Phenomena, Nanoparticles chemistry
- Abstract
A dually responsive nanocarrier with multilayer core-shell architecture was prepared based on Fe(3)O(4)@SiO(2) nanoparticles coated with mPEG-poly(l-Asparagine). Imidazole groups (pK(a)∼6.0) were tethered to the side chains of poly(l-Asparagine) segments by aminolysis. These nanoparticles were expected to be sensitive to both magnetic field and pH environment. The obtained materials were characterized with FTIR, dynamic light scattering, ζ-potential, TEM, TGA and hysteresis loop analysis. It was found that this Fe(3)O(4)@SiO(2)-polymer complex can form nano-scale core-shell-corona trilayer particles (∼250 nm) in aqueous solution. The Fe(3)O(4)@SiO(2), poly(L-Asparagine) and mPEG segments serve as a super-paramagnetic core, a pH-sensitive shell, and a hydrophilic corona, respectively. An antitumor agent, doxorubicin (DOX), was successfully loaded into the nanocarrier via combined actions of hydrophobic interaction and hydrogen bonding. The drug release profiles displayed a pH-dependent behavior. DOX release rate increased significantly as the ambient pH dropped from the physiological pH (7.4) to acidic (5.5). This is most likely due to protonation and a change in hydrophilicity of the imidazole groups in the poly(l-Asparagine) segments. This new approach may serve as a promising platform to formulate magnetic targeted drug delivery systems., (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Published
- 2013
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209. A novel delivery system of doxorubicin with high load and pH-responsive release from the nanoparticles of poly (α,β-aspartic acid) derivative.
- Author
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Wang X, Wu G, Lu C, Zhao W, Wang Y, Fan Y, Gao H, and Ma J
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- Cells, Cultured, Drug Delivery Systems methods, Humans, Hydrogen-Ion Concentration, Hydrophobic and Hydrophilic Interactions, Micelles, Polyethylene Glycols chemistry, Polymers chemical synthesis, Aspartic Acid administration & dosage, Aspartic Acid chemistry, Doxorubicin administration & dosage, Doxorubicin chemistry, Nanoparticles administration & dosage, Nanoparticles chemistry, Polymers administration & dosage, Polymers chemistry
- Abstract
A poly (amino acid)-based amphiphilic copolymer was utilized to fabricate a better micellar drug delivery system (DDS) with improved compatibility and sustained release of doxorubicin (DOX). First, poly (ethylene glycol) monomethyl ether (mPEG) and DOX were conjugated onto polyasparihyazide (PAHy), prepared by hydrazinolysis of the poly (succinimide) (PSI), to afford an amphiphilic polymer [PEG-hyd-P (AHy-hyd-DOX)] with acid-liable hydrazone bonds. The DOX, chemically conjugated to the PAHy, was designed to supply hydrophobic segments. PEGs were also grafted to the polymer via hydrazone bonds to supply hydrophiphilic segments and prolong its lifetime in blood circulation. Free DOX molecules could be entrapped into the nanoparticles fabricated by such an amphiphilic polymer (PEG-hyd-P (AHy-hyd-DOX)), via hydrophobic interaction and π-π stacking between the conjugated and free DOX molecules to obtain a pH responsive drug delivery system with high DOX loaded. The drug loading capacity, drug release behavior, and morphology of the micelles were investigated. The biological activity of micelles was evaluated in vitro. The drug loading capacity was intensively augmented by adjusting the feed ratio, and the maximum loading capacity was as high as 38%. Besides, the DOX-loaded system exhibited pH-dependent drug release profiles in vitro. The cumulative release of DOX was much faster at pH 5.0 than that at pH 7.4. The DOX-loaded system kept highly antitumor activity for a long time, compared with free DOX. This easy-prepared DDS, with features of biocompatibility, biodegradability, high drug loading capacity and pH-responsiveness, was a promising controlled release delivery system for DOX., (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Published
- 2012
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210. Synthesis of a novel zwitterionic biodegradable poly (α,β-L-aspartic acid) derivative with some L-histidine side-residues and its resistance to non-specific protein adsorption.
- Author
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Wang X, Wu G, Lu C, Wang Y, Fan Y, Gao H, and Ma J
- Subjects
- Adsorption, Histidine chemistry, Peptides chemical synthesis, Peptides chemistry, Proteins chemistry
- Abstract
A novel zwitterionic polypeptide derivative, denoted as His-PAsp/PAsp, was successfully synthesized by amidation of Poly (α,β-L-aspartic acid) with L-histidine methyl ester. Turbidity, zeta potential and ¹H NMR measurements were used to study the aggregation behaviors of His-PAsp/PAsp under different pH values. The modified polypeptide derivative composed of electro-negatively carboxylic and electro-positively imidazole residues randomly so as to bear opposite charges at pH values above or below the isoelectric point. When the zwitterionic polypeptide was coated on silicon wafer as a model substrate material, the absorption resistance of fibrinogen, a blood protein resulting in the blood coagulation cascade, on the coated surface was measured. It was found that the adsorption amount of fibrinogen on the polypeptide-coated surface depended on the dose of the polypeptide on silicon wafer. Obvious resistance of the fibrinogen adsorption on the polypeptide-coated surface was observed. Since its good biodegradability and superior anti-protein-fouling property, this pH-responsive zwitterionic polypeptide is a promising candidate for surface modification in many biomedical applications, including medical implants, drug delivery carriers, and biosensors., (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Published
- 2011
- Full Text
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211. Enhanced adsorption of phenol from water by a novel polar post-crosslinked polymeric adsorbent.
- Author
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Zeng X, Fan Y, Wu G, Wang C, and Shi R
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- Adsorption, Diffusion, Polymers chemical synthesis, Solutions, Thermodynamics, Phenol isolation & purification, Polymers chemistry, Water Pollutants, Chemical isolation & purification, Water Purification methods
- Abstract
A novel post-crosslinked polymeric adsorbent PDM-2 was prepared by Friedel-Crafts reaction of pendant vinyl groups without external crosslinking agent. Both the specific surface area and the pore volume of starting copolymer PDM-1 increased significantly after post-crosslinking. Batch adsorption runs of phenol from aqueous solution onto PDM-1 and PDM-2 were investigated. Commercial macroporous resins XAD-4 and AB-8 were chosen as the comparison. Experimental results showed that isotherms of phenol adsorption onto these four polymeric adsorbents could be represented by Freundlich model reasonably. PDM-2 exhibited higher adsorption capacity of phenol than other three adsorbents, which resulted from synergistic effect of larger specific surface area and polar groups on the network. The adsorption process for phenol was proved to be exothermic and spontaneous in nature. Thermodynamic parameters such as Gibb's free energy (DeltaG), change in enthalpy (DeltaH) and change in entropy (DeltaS) were calculated. Kinetics studies indicated that phenol uptake onto PDM-1 and PDM-2 followed the pseudo-second order model and the intraparticle diffusion process was a rate-controlling step. Column adsorption runs demonstrated that nearly 100% regeneration efficiency for PDM-2 by 3BV industrial alcohol and the adsorbate phenol can be easily recovered by further distilling. Continuous column adsorption-regeneration cycles indicated negligible capacity loss of PDM-2 during operation.
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- 2009
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212. pH-responsive self-assembly and conformational transition of partially propyl-esterified poly(alpha,beta-L-aspartic acid) as amphiphilic biodegradable polyanion.
- Author
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Wang Y, Wang Y, Wu G, Fan Y, and Ma J
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- Biocompatible Materials chemical synthesis, Circular Dichroism, Hydrogen-Ion Concentration, Hydrophobic and Hydrophilic Interactions, Microscopy, Electron, Scanning, Microscopy, Electron, Transmission, Molecular Conformation, Polyelectrolytes, Polymers chemical synthesis, Biocompatible Materials chemistry, Polymers chemistry
- Abstract
Poly(alpha,beta-L-aspartate) (PAsp) was partially esterified to afford an amphiphilic biodegradable polyanion, poly(sodium aspartate-co-propyl aspartate) (PAsp-Na/PAsp-P). The synthesized polyanion could be assembled into the nano-scaled aggregates in aqueous medium. The aggregate morphologies were studied by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) as a function of pH. It was demonstrated that micellization of this random copolymer occurred with stimulus of pH changes to form various morphological micelles. The copolymer existed as precipitate at low pH (pH<2). When pH increased to 4, the polymers were associated into spherical micelles with the core of poly(propyl aspartate) (PAsp-P) hydrophobic units and shell of some negatively charged poly(sodium aspartate) (PAsp-Na) units. At higher pH (pH>5), toroidal nanostructures of the micelles were formed because rigid polyamide chains directly assemble into the large hollow spheres. The CD study showed that the conformation underwent a transition between alpha-helix and random coil at pH 3-7. The cooperative transitions were regulated by the degree of ionization of carboxylic side chains. When they were protonated (neutralized), the molecular backbone was in favor of the regular helical structure; when deprotonated (ionized), the electrostatic repulsions among side chains destabilized the intramolecular hydrogen bonds, thus randomizing the regular conformation.
- Published
- 2009
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