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10,908 results on '"Wu, Pei"'

218. Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?

Author

Park, JooYong, Choi, Ji-Yeob, Choi, Jaesung, Chung, Seokang, Song, Nan, Park, Sue K, Han, Wonshik, Noh, Dong-Young, Ahn, Sei-Hyun, Lee, Jong Won, Kim, Mi Kyung, Jee, Sun Ha, Wen, Wanqing, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Michailidou, Kyriaki, Shah, Mitul, Conroy, Don M, Harrington, Patricia A, Mayes, Rebecca, Czene, Kamila, Hall, Per, Teras, Lauren R, Patel, Alpa V, Couch, Fergus J, Olson, Janet E, Sawyer, Elinor J, Roylance, Rebecca, Bojesen, Stig E, Flyger, Henrik, Lambrechts, Diether, Baten, Adinda, Matsuo, Keitaro, Ito, Hidemi, Guénel, Pascal, Truong, Thérèse, Keeman, Renske, Schmidt, Marjanka K, Wu, Anna H, Tseng, Chiu-Chen, Cox, Angela, Cross, Simon S, kConFab Investigators, Andrulis, Irene L, Hopper, John L, Southey, Melissa C, Wu, Pei-Ei, Shen, Chen-Yang, Fasching, Peter A, Ekici, Arif B, Muir, Kenneth, Lophatananon, Artitaya, Brenner, Hermann, Arndt, Volker, Jones, Michael E, Swerdlow, Anthony J, Hoppe, Reiner, Ko, Yon-Dschun, Hartman, Mikael, Li, Jingmei, Mannermaa, Arto, Hartikainen, Jaana M, Benitez, Javier, González-Neira, Anna, Haiman, Christopher A, Dörk, Thilo, Bogdanova, Natalia V, Teo, Soo Hwang, Mohd Taib, Nur Aishah, Fletcher, Olivia, Johnson, Nichola, Grip, Mervi, Winqvist, Robert, Blomqvist, Carl, Nevanlinna, Heli, Lindblom, Annika, Wendt, Camilla, Kristensen, Vessela N, Nbcs Collaborators, Tollenaar, Rob AEM, Heemskerk-Gerritsen, Bernadette AM, Radice, Paolo, Bonanni, Bernardo, Hamann, Ute, Manoochehri, Mehdi, Lacey, James V, Martinez, Maria Elena, Dunning, Alison M, Pharoah, Paul DP, Easton, Douglas F, Yoo, Keun-Young, and Kang, Daehee

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Human Genome, Estrogen, Prevention, Aging, Genetics, Women's Health, Clinical Research, Cancer, Breast Cancer, 2.1 Biological and endogenous factors, breast cancer, estrogen, gene-environment interaction, Oncology and carcinogenesis
Abstract

In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 × 10-3). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE|2df model (p-2df = 1.1 × 10-4). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.

Published
2021

234. Contributors

Author

Norman, Abdul Rahim, primary, Koulouris, Alexandros, additional, Yu, Bor-Yih, additional, Tsai, Chang-Che, additional, Chong, Chien Hwa, additional, Ng, Denny K.S., additional, Foo, Dominic C.Y., additional, Chong, Jia Wen, additional, Goo, Jie Yi, additional, Tapia, John Frederick D., additional, Ng, Lik Yin, additional, Van der Spek, Mijndert, additional, Chemmangattuvalappil, Nishanth, additional, Bt Hussein, Noorhidayah, additional, Roslizam, Nurain Shakina, additional, Wu, Pei-Jhen, additional, Diban, Pitchaimuthu, additional, Elyas, Rafil, additional, Ooi, Raymond E.H., additional, Lim, Rebecca, additional, Ma, Rui, additional, Abidin, Shahrul Azman, additional, Lin, Shiang-Tai, additional, Chong, Siewhui, additional, Azhari, Siti Nurfaqihah, additional, Adi, Vincentius Surya Kurnia, additional, and Putra, Zulfan Adi, additional

Published
2023
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238. Refining Protein Envelopes with a Transition Region for Enhanced Direct Phasing in Protein Crystallography

Author

Ruijiang Fu, Wu-Pei Su, and Hongxing He

Subjects
protein envelope, direct method, ab initio phasing, transition, hybrid input–output algorithm, protein crystallography, Crystallography, QD901-999
Abstract

In protein crystallography, the determination of an accurate protein envelope is of paramount importance for ab initio phasing of diffraction data. In our previous work, we introduced an approach to ascertain the protein envelope by seeking an optimal cutoff value on a weighted-average density map. In this paper, we present a significant advancement in our approach by focusing on identifying a transition region that demarcates the boundary between the protein and solvent regions, rather than relying solely on a single cutoff value. Within this transition region, we conducted a meticulous search for the protein envelope using a finer map and our proposed transition hybrid input–output (THIO) algorithm. Through this improvement, we achieved a refined protein envelope even when starting from random phases, enabling us to determine protein structures with irregular envelopes and successfully phase crystals with reduced solvent contents. To validate the efficacy of our method, we conducted tests using real diffraction data from five protein crystals, each containing solvent contents ranging from 60% to 65%. Solving these structures through conventional direct methods proved difficult due to the limited solvent content. The mean phase error obtained through our proposed method was about 30°. The reconstructed model matched with the structure in the protein data bank with a root mean square deviation (r.m.s.d.) of about 1 Å. These results serve as compelling evidence that the utilization of the proposed transition region in conjunction with the THIO algorithm contributes significantly to the construction of a reliable protein envelope. This, in turn, becomes indispensable for the direct phasing of protein crystals with lower solvent contents.

Published
2024
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239. A controllable superconducting electromechanical oscillator with a suspended membrane

Author

Li, Yong-Chao, Tang, Jiang-shan, Jiang, Jun-Liang, Pan, Jia-Zheng, Dai, Xin, Wei, Xing-Yu, Lu, Ya-Peng, Lu, Sheng, Tu, Xue-Cou, Wang, Hua-bing, Xia, Ke-yu, Sun, Guo-Zhu, and Wu, Pei-Heng

Subjects
Physics - Applied Physics, Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Optics, Quantum Physics
Abstract

We fabricate a microscale electromechanical system, in which a suspended superconducting membrane, treated as a mechanical oscillator, capacitively couples to a superconducting microwave resonator. As the microwave driving power increases, nonmonotonic dependence of the resonance frequency of the mechanical oscillator on the driving power has been observed. We also demonstrate the optical switching of the resonance frequency of the mechanical oscillator. Theoretical models for qualitative understanding of our experimental observations are presented. Our experiment may pave the way for the application of a mechanical oscillator with its resonance frequency controlled by the electromagnetic and/or optical fields, such as a microwave-optical interface and a controllable element in a superqubit-mechanical oscillator hybrid system., Comment: 8 pages,4 figures

Published
2019
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240. AutoGAN-based Dimension Reduction for Privacy Preservation

Author

Nguyen, Hung, Zhuang, Di, Wu, Pei-Yuan, and Chang, Morris

Subjects
Computer Science - Cryptography and Security
Abstract

Protecting sensitive information against data exploiting attacks is an emerging research area in data mining. Over the past, several different methods have been introduced to protect individual privacy from such attacks while maximizing data-utility of the application. However, these existing techniques are not sufficient to effectively protect data owner privacy, especially in the scenarios that utilize visualizable data (e.g. images, videos) or the applications that require heavy computations for implementation. To address these problems, we propose a new dimension reduction-based method for privacy preservation. Our method generates dimension-reduced data for performing machine learning tasks and prevents a strong adversary from reconstructing the original data. We first introduce a theoretical approach to evaluate dimension reduction-based privacy preserving mechanisms, then propose a non-linear dimension reduction framework motivated by state-of-the-art neural network structures for privacy preservation. We conducted experiments over three different face image datasets (AT&T, YaleB, and CelebA), and the results show that when the number of dimensions is reduced to seven, we can achieve the accuracies of 79%, 80%, and 73% respectively and the reconstructed images are not recognizable to naked human eyes.

Published
2019
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243. Near-Optimal Lower Bounds on the Threshold Degree and Sign-Rank of AC^0

Author

Sherstov, Alexander A. and Wu, Pei

Subjects
Computer Science - Computational Complexity
Abstract

The threshold degree of a Boolean function $f\colon\{0,1\}^n\to\{0,1\}$ is the minimum degree of a real polynomial $p$ that represents $f$ in sign: $\mathrm{sgn}\; p(x)=(-1)^{f(x)}.$ A related notion is sign-rank, defined for a Boolean matrix $F=[F_{ij}]$ as the minimum rank of a real matrix $M$ with $\mathrm{sgn}\; M_{ij}=(-1)^{F_{ij}}$. Determining the maximum threshold degree and sign-rank achievable by constant-depth circuits ($\text{AC}^{0}$) is a well-known and extensively studied open problem, with complexity-theoretic and algorithmic applications. We give an essentially optimal solution to this problem. For any $\epsilon>0,$ we construct an $\text{AC}^{0}$ circuit in $n$ variables that has threshold degree $\Omega(n^{1-\epsilon})$ and sign-rank $\exp(\Omega(n^{1-\epsilon})),$ improving on the previous best lower bounds of $\Omega(\sqrt{n})$ and $\exp(\tilde{\Omega}(\sqrt{n}))$, respectively. Our results subsume all previous lower bounds on the threshold degree and sign-rank of $\text{AC}^{0}$ circuits of any given depth, with a strict improvement starting at depth $4$. As a corollary, we also obtain near-optimal bounds on the discrepancy, threshold weight, and threshold density of $\text{AC}^{0}$, strictly subsuming previous work on these quantities. Our work gives some of the strongest lower bounds to date on the communication complexity of $\text{AC}^{0}$., Comment: 99 pages

Published
2019

246. China and Russia's leaders hail their opposition to U.S.-led world order

Author

Lee, Michelle Ye Hee and Wu, Pei-Lin

Subjects
Russian Invasion of Ukraine, 2022-, Opposition (Political science), General interest, News, opinion and commentary
Abstract

Byline: Michelle Ye Hee Lee, Pei-Lin Wu Russian President Vladimir Putin touted his country's relations with China as a âstabilizingâ force in the world as he began his two-day state [...]

Published
2024

247. Putin hails Russia's ties with China as âstabilizing' force in the world

Author

Lee, Michelle Ye Hee and Wu, Pei-Lin

Subjects
Russian Invasion of Ukraine, 2022-, General interest, News, opinion and commentary
Abstract

Byline: Michelle Ye Hee Lee, Pei-Lin Wu Russian President Vladimir Putin touted his country's relations with China as a âstabilizingâ force in the world as he began a two-day state [...]

Published
2024

248. Mamaâs boys and marital strife are no joke in todayâs China

Author

Shepherd, Christian and Wu, Pei-Lin

Subjects
Marriage, Censorship, Censorship issue, General interest, News, opinion and commentary
Abstract

Byline: Christian Shepherd, Pei-Lin Wu Tales about evil mothers-in-law have landed Chinaâs wildly popular ultrashort dramas in trouble with official censors. Bossy matriarchs who baby their adult sons are a [...]

Published
2024

249. Huge Taiwan quake caused few deaths thanks to preparedness â and luck

Author

Kuo, Lily, Wu, Pei-Lin, and Chiang, Vic

Subjects
Taiwan Earthquake, 2024, Building law -- Influence, Earthquake damage -- Evaluation -- Taiwan, Search and rescue operations, Earthquake resistant design -- Usage, Emergency management -- Evaluation, Disaster planning, General interest, News, opinion and commentary
Abstract

Byline: Lily Kuo, Pei-Lin Wu, Vic Chiang TAIPEI, Taiwan - Motorcyclists waited calmly on a bridge as it rocked violently; nurses looking after a group of infants quickly pushed their [...]

Published
2024

250. Taiwan hit by its strongest quake in quarter-century, but death toll is low

Author

Kuo, Lily, Inuma, Julie Mio, Chiang, Vic, Wu, Pei-Lin, and Ledur, Júlia

Subjects
Taiwan Earthquake, 2024, Building law -- Interpretation and construction, Earthquake damage -- Evaluation -- Taiwan, Earthquake resistant design -- Usage, Emergency management -- Influence, Disaster planning, General interest, News, opinion and commentary
Abstract

Byline: Lily Kuo, Julie Mio Inuma, Vic Chiang, Pei-Lin Wu, Júlia Ledur TAIPEI, Taiwan - A 7.4-magnitude earthquake struck the east coast of Taiwan on Wednesday morning, killing nine people [...]

Published
2024

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