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1,664 results on '"Yang, Yanan"'

201. Abstract 1878: Preclinical development of a novel bispecific mAb-Trap fusion protein, IMM2520, targeting both PD-L1 and CD47 as cancer immunotherapy

Author

Tian, Wenzhi, primary, Li, Song, additional, Chen, Dianze, additional, Zhu, Wenqi, additional, Yang, Yanan, additional, Liu, Dandan, additional, Guo, Huiqin, additional, Yang, Chunmei, additional, Zhang, Li, additional, Zhang, Wei, additional, Tu, Xiaoping, additional, Peng, Liang, additional, Zhao, Gui, additional, Zhang, Ruliang, additional, Zhang, Fan, additional, and Gan, Frank, additional

Published
2023
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202. Supplementary Figure 1 from miR-200 Inhibits Lung Adenocarcinoma Cell Invasion and Metastasis by Targeting Flt1/VEGFR1

Author

Roybal, Jonathon D., primary, Zang, Yi, primary, Ahn, Young-Ho, primary, Yang, Yanan, primary, Gibbons, Don L., primary, Baird, Brandi N., primary, Alvarez, Cristina, primary, Thilaganathan, Nishan, primary, Liu, Diane D., primary, Saintigny, Pierre, primary, Heymach, John V., primary, Creighton, Chad J., primary, and Kurie, Jonathan M., primary

Published
2023
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203. Supplementary Tables 1-2 from miR-200 Inhibits Lung Adenocarcinoma Cell Invasion and Metastasis by Targeting Flt1/VEGFR1

Author

Roybal, Jonathon D., primary, Zang, Yi, primary, Ahn, Young-Ho, primary, Yang, Yanan, primary, Gibbons, Don L., primary, Baird, Brandi N., primary, Alvarez, Cristina, primary, Thilaganathan, Nishan, primary, Liu, Diane D., primary, Saintigny, Pierre, primary, Heymach, John V., primary, Creighton, Chad J., primary, and Kurie, Jonathan M., primary

Published
2023
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204. Supplementary Figure Legend from miR-200 Inhibits Lung Adenocarcinoma Cell Invasion and Metastasis by Targeting Flt1/VEGFR1

Author

Roybal, Jonathon D., primary, Zang, Yi, primary, Ahn, Young-Ho, primary, Yang, Yanan, primary, Gibbons, Don L., primary, Baird, Brandi N., primary, Alvarez, Cristina, primary, Thilaganathan, Nishan, primary, Liu, Diane D., primary, Saintigny, Pierre, primary, Heymach, John V., primary, Creighton, Chad J., primary, and Kurie, Jonathan M., primary

Published
2023
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205. Data from miR-200 Inhibits Lung Adenocarcinoma Cell Invasion and Metastasis by Targeting Flt1/VEGFR1

Author

Roybal, Jonathon D., primary, Zang, Yi, primary, Ahn, Young-Ho, primary, Yang, Yanan, primary, Gibbons, Don L., primary, Baird, Brandi N., primary, Alvarez, Cristina, primary, Thilaganathan, Nishan, primary, Liu, Diane D., primary, Saintigny, Pierre, primary, Heymach, John V., primary, Creighton, Chad J., primary, and Kurie, Jonathan M., primary

Published
2023
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207. Discovery of Natural Ah Receptor Antagonists from Salvia miltiorrhizaBunge and Synthesis of Analogs for Tumor Immunotherapy

Author

Li, Zhenyuan, Li, Shuying, Xing, Zeyu, Gu, Quanchang, Du, Rongrong, Jiang, Jianshuang, Yuan, Xiang, Zhang, Xu, Chen, Xiaoguang, Xue, Nina, Zhang, Peicheng, Jin, Jing, and Yang, Yanan

Abstract

IDO/TDO/Kyn/AhR signaling plays a crucial role in regulating innate and adaptive immunity, and targeting Ah receptor (AhR) inhibition can potentially redirect immune cells toward an antitumoral phenotype. Therefore, AhR is an attractive drug target for novel small molecule cancer immunotherapies. In this study, natural products tanshinolic A–D (1–4), the first adducts composed of ortho-naphthoquinone-type tanshinone and phenolic acid featuring a unique 1,4-benzodioxan hemiacetal structure, were isolated and characterized from the roots of Salvia miltiorrhizaBunge. Luciferase reporter gene assay revealed that these adducts exhibited significant AhR inhibitory activity. A linear strategy was developed to construct a cis-3,4-disubstituted 1,4-benzodioxan hemiacetal structure. Encouragingly, in both invitroand invivoexperiments, (±)-13edemonstrated the ability to inhibit tumor cell proliferation, promote INF-γ secretion in CD8+T cells, and inhibit PD-1/PD-L1 signal transduction, which could exert tumor inhibition properties by inhibiting AhR activity, positioning it as a promising candidate for tumor immunotherapy.

Published
2024
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208. Chinese multinationals post-merger integration evolutions in developed markets from autonomy to actual-form integration: a lens of ambidexterity.

Author

Yang, Yanan

Subjects
AMBIDEXTERITY, CHINESE language, VALUE creation, INTERNATIONAL business enterprises, GERMAN language, CONTENT analysis
Abstract

Purpose: This paper aims to examine how Chinese multinational enterprises' (CMNEs) autonomy-style post-merger integration (PMI) modes of managing developed-market targets evolve into actual-form integration through the lens of ambidexterity. Design/methodology/approach: This study adopts multi-case comparisons with content analysis. A data set was collected from 37 conversations by in-depth interviewing 29 respondents regarding four cases of Chinese acquisitions in the German market. Findings: This study develops a three-stage framework that theorised CMNEs' autonomy PMIs' evolution to actual-form integration over time and the effect on acquisition value based on structural, temporal and contextual ambidexterity manifestations. The findings divide the evolutionary trajectory into two sub-trajectories, from great autonomy to autonomy-integration balanced or full integration, to illuminate the effect of different degrees of actual-form integration on value creation or value destruction. Originality/value: The existing literature on CMNEs' PMI discovered that CMNEs frequently grant ample autonomy when managing targets acquired from developed markets. However, long-term acquisition benefit is dependent on combining autonomy and actual-form integration; insights into how this can be accomplished are limited. The research is unique in that it reveals the evolutions of CMNEs' PMIs on developed-market targets, from autonomy to actual-form integration through the lens of ambidexterity. [ABSTRACT FROM AUTHOR]

Published
2023
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209. Mammalian esophageal stratified tissue homeostasis is maintained distinctively by the epithelial pluripotent p63+Sox2+ and p63−Sox2+ cell populations.

Author

Yu, Xiaohong, Yuan, Hui, Yang, Yanan, Zheng, Wei, Zheng, Xuejing, Lu, Shih-Hsin, Jiang, Wei, and Yu, Xiying

Abstract

Self-renewing, damage–repair and differentiation of mammalian stratified squamous epithelia are subject to tissue homeostasis, but the regulation mechanisms remain elusive. Here, we investigate the esophageal squamous epithelial tissue homeostasis in vitro and in vivo. We establish a rat esophageal organoid (rEO) in vitro system and show that the landscapes of rEO formation, development and maturation trajectories can mimic those of rat esophageal epithelia in vivo. Single-cell RNA sequencing (scRNA-seq), snapshot immunostaining and functional analyses of stratified “matured” rEOs define that the epithelial pluripotent stem cell determinants, p63 and Sox2, play crucial but distinctive roles for regulating mammalian esophageal tissue homeostasis. We identify two cell populations, p63+Sox2+ and p63−Sox2+, of which the p63+Sox2+ population presented at the basal layer is the cells of origin required for esophageal epithelial stemness maintenance and proliferation, whereas the p63−Sox2+ population presented at the suprabasal layers is the cells of origin having a dual role for esophageal epithelial differentiation (differentiation-prone fate) and rapid tissue damage–repair responses (proliferation-prone fate). Given the fact that p63 and Sox2 are developmental lineage oncogenes and commonly overexpressed in ESCC tissues, p63−Sox2+ population could not be detected in organoids formed by esophageal squamous cell carcinoma (ESCC) cell lines. Taken together, these findings reveal that the tissue homeostasis is maintained distinctively by p63 and/or Sox2-dependent cell lineage populations required for the tissue renewing, damage–repair and protection of carcinogenesis in mammalian esophagi. [ABSTRACT FROM AUTHOR]

Published
2023
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213. Supplementary Figures 1-4 from Pten Inactivation Accelerates Oncogenic K-ras–Initiated Tumorigenesis in a Mouse Model of Lung Cancer

Author

Iwanaga, Kentaro, primary, Yang, Yanan, primary, Raso, Maria Gabriela, primary, Ma, Lijiang, primary, Hanna, Amy E., primary, Thilaganathan, Nishan, primary, Moghaddam, Seyed, primary, Evans, Christopher M., primary, Li, Huaiguang, primary, Cai, Wei-Wen, primary, Sato, Mitsuo, primary, Minna, John D., primary, Wu, Hong, primary, Creighton, Chad J., primary, Demayo, Francesco J., primary, Wistuba, Ignacio I., primary, and Kurie, Jonathan M., primary

Published
2023
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214. Data from Pten Inactivation Accelerates Oncogenic K-ras–Initiated Tumorigenesis in a Mouse Model of Lung Cancer

Author

Iwanaga, Kentaro, primary, Yang, Yanan, primary, Raso, Maria Gabriela, primary, Ma, Lijiang, primary, Hanna, Amy E., primary, Thilaganathan, Nishan, primary, Moghaddam, Seyed, primary, Evans, Christopher M., primary, Li, Huaiguang, primary, Cai, Wei-Wen, primary, Sato, Mitsuo, primary, Minna, John D., primary, Wu, Hong, primary, Creighton, Chad J., primary, Demayo, Francesco J., primary, Wistuba, Ignacio I., primary, and Kurie, Jonathan M., primary

Published
2023
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215. Supplementary Table 3 from Pten Inactivation Accelerates Oncogenic K-ras–Initiated Tumorigenesis in a Mouse Model of Lung Cancer

Author

Iwanaga, Kentaro, primary, Yang, Yanan, primary, Raso, Maria Gabriela, primary, Ma, Lijiang, primary, Hanna, Amy E., primary, Thilaganathan, Nishan, primary, Moghaddam, Seyed, primary, Evans, Christopher M., primary, Li, Huaiguang, primary, Cai, Wei-Wen, primary, Sato, Mitsuo, primary, Minna, John D., primary, Wu, Hong, primary, Creighton, Chad J., primary, Demayo, Francesco J., primary, Wistuba, Ignacio I., primary, and Kurie, Jonathan M., primary

Published
2023
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216. Supplementary Figure Legends 1-4 from Pten Inactivation Accelerates Oncogenic K-ras–Initiated Tumorigenesis in a Mouse Model of Lung Cancer

Author

Iwanaga, Kentaro, primary, Yang, Yanan, primary, Raso, Maria Gabriela, primary, Ma, Lijiang, primary, Hanna, Amy E., primary, Thilaganathan, Nishan, primary, Moghaddam, Seyed, primary, Evans, Christopher M., primary, Li, Huaiguang, primary, Cai, Wei-Wen, primary, Sato, Mitsuo, primary, Minna, John D., primary, Wu, Hong, primary, Creighton, Chad J., primary, Demayo, Francesco J., primary, Wistuba, Ignacio I., primary, and Kurie, Jonathan M., primary

Published
2023
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217. Supplementary Tables 1-2 from Pten Inactivation Accelerates Oncogenic K-ras–Initiated Tumorigenesis in a Mouse Model of Lung Cancer

Author

Iwanaga, Kentaro, primary, Yang, Yanan, primary, Raso, Maria Gabriela, primary, Ma, Lijiang, primary, Hanna, Amy E., primary, Thilaganathan, Nishan, primary, Moghaddam, Seyed, primary, Evans, Christopher M., primary, Li, Huaiguang, primary, Cai, Wei-Wen, primary, Sato, Mitsuo, primary, Minna, John D., primary, Wu, Hong, primary, Creighton, Chad J., primary, Demayo, Francesco J., primary, Wistuba, Ignacio I., primary, and Kurie, Jonathan M., primary

Published
2023
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236. Modulative effect of Physalis alkekengion both gut bacterial and fungal micro-ecosystem

Author

Yang, Yanan, Zhao, Xiaohui, Xie, Yong, and Wu, Chongming

Abstract

Gut microbiome is an intricate micro-ecosystem mediating the human health and drug efficacy. Physalis alkekengi(PAL) is an edible and time-honored traditional Chinese medicine. Several pharmacological effects of PAL have been verified and gut bacteria are implied in its therapeutic actions. However, the detailed modulation of PAL on gut bacterial species and on gut fungi remains largely unknown. We, therefore, designed a preliminary experiment in normal mice to reveal the modulation effect of PAL on both gut bacteria and fungi, and explore the interaction between them.

Published
2023
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