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Undang-undang nomor 2 tahun 2011 tentang perubahan atas Undang-undang nomor 2 tahun 2008 tentang Partai Politik menyatakan “Pendidikan politik adalah proses pembelajaran tentang hak, kewajiban dan tanggung jawab setiap warga negara dalam kehidupan berbangsa dan bernegara. Politik sering diartikan sebagai seni atau ilmu untuk meraih kekuasaan, pada pratiknya banyak timbul penyimpangan-penyimpangan dalam rangka memperoleh kekuasaan itu sendiri. Pemuda sebagai generasi penerus yang akan memegang tampuk kepemimpinan kedepan, tentu harus melek politik, tidak hanya politik praktis, tetapi juga menentukan arah kemajuan negara. Tujuan dilakukanya pengabdian masyarakat ini untuk memberikan pemahaman kepada siswa di Sekolah Madrasah Aliyah Swasta, Pesantren Baitul Arqam Sibreh tentang pendidikan politik, pemahaman bagi siswa Sekolah Madrasah Aliyah Swasta, di Pesantren Baitul Arqam Sibreh tentang politik. Hasil yang dicapai dalam kegiatan pengabdian masyarakat adalah menunjukan peningkatan pengetahuan dan pemahaman, ditandai dengan partisipasi peserta yang mengajukan pertanyaan sesuai dengan materi penyuluhan hukum. Diharapkan dapat menumbuhkan pengetahuan peserta dan dapat berpartisipasi secara aktif dalam penggunaan hak politik baik bagi sendiri maupun orang lain. Subtansi pemuda sebagai pemilih pemula tidak menjadi objek politik tetapi juga berperan sebagai subjek politik. Disarankan kepada peserta penyuluhan agar menindak lanjuti aspek pengetahuan dan sikap untuk diperaktikan dalam kehidupan sehari-hari berkaitan dengan pendidikan politik. Kegiatan penyuluhan hukum kepada santri dan santriwati Pesantren Darul Arqam Kecamatan Suka Makmur Aceh Besar, seharusnya dilakukan bersama instansi terkait dengan materi-materi hukum lain, sehingga dapat tercapi tujuan yang ingin di inginkan..Kata kunci : Pendidikan Politik, Pemuda, Pesanteren.ABSTRACTThe Law Number 2 Year 2011 amandment of The Law Number 2 Year 2008 about Political Party saysthat, ‘ Political education is a learning process about rights, obligations and responsibility every citizens in the life of the people and of the nation. Politics commonly interpreted as art or knowledge to gain power, in fact there are distortions in order to gain it power. Youths as next generation who will hold the reins of power in the future, surely have to open their eyes on politics, not only political practice, but also determine the direction of the country. The goal of this community service was to educate students in Baitul Arqam Senior High School Sibreh about political education. The results achieved in community service activities are showing an increase in knowledge and understanding, seen at the participation of participants who asked questions in accordance with the legal counseling material. It is hoped that it will increase the knowledge of participants and be able to participate actively in the use of political rights, both for themselves and for others. The substance of youth as novice voters does not become a political object but also acts as a political subject. It is suggested to the counseling participants to follow up on aspects of knowledge and attitudes to be practiced in dailylife related to political education. Legal counseling activities for students of the Darul Arqam Islamic Boarding School, Suka Makmur District, Aceh Besar, should be carried out together with related agencies with other legal materials, so that the goals to be achieved can be achieved.Keywords: Political Education, Youth, Boarding School

The purpose of this study was to analyze the effect of spillway width on flow elevation at the weir crest based on the flood discharge design for the Probable Maximum Flood (PMF) return period using flood routing hydrologically at the Cacaban Dam (Indonesia). The rainfall Probable Maximum Precipitation (PMP) design uses the Hershfield Equation. The design of the flood discharge analysis of QPMF used the Nakayasu Synthetic Unit Hydrograph (HSS). Flood routing uses the hydrologic routing method. The Cacaban Dam is located in Jati Village, Kedung Banteng District, Tegal Regency, Central Java Province, Indonesia. The results of the research data analysis showed that increased spillway crest widths led to decreased flow evaluation at the spillway crest, and increased outflow discharge. Thus, if a large storage volume of the reservoir is intended, then the width of the spillway crest must be reduced. Otherwise, the width of the spillway crest must be increased. In terms of flood control in the Tegal Regency, it's better to make the crest of the spillway smaller. Doi: 10.28991/CEJ-2022-08-04-08 Full Text: PDF

This paper aims at answering two following questions: (1). What are the types of negative markers in Kiwangona dialects of the Lamaholot based on Mosel and Spriggs’ negation patterns ? ; (2). To what extent do negative markers in the Kiwangona dialect fill the stages in Jespersen Cycle? This research is qualitative in nature. The data were obtained from a two-week field trip to Bayunta’a village of Ile Boleng subdistrict on Adonara island. Data were collected through a series of elicitation processes and note-taking activities from five informants. The data were then analyzed by using Mosel and Spriggs’s theory of negation patterns (1999) as well as the stages of the Jespersen Cycle (1917). Results show that (1) negative markers in Kiwangona fill all five kinds of negative patterns hypothesized by Mosel and Spriggs. Second, the most significant finding is that due to historical contact with a non-Austronesian language, Kiwangona as a single dialect fills all three stages of the Jespersen Cycle compared to Fricke's assessment on negative markers in Flores-Lembata languages. Furthermore, certain lexico-grammatical changes that appeared in Kiwangona negative clauses are mainly due to grammaticalization and a higher degree of negators' movability. Dealing with the results above, the Kiwangona dialect may be considered as a more complex Lamaholot dialect in terms of negation patterns compared to others. Therefore, more research should be carried out on many other undocumented dialects in order to end up with a clearer situation of the negation in Lamaholot dialects.

Background: The immunological shift occurring in pregnant women is crucial for the outcome of pregnancy. We conducted a study in pregnant women living in a malaria endemic area to determine the potential effect of gestational age on modulating the immune system by cortisol and prolactin production. Methods: Primigravidae and multigravidae with a gestational age between 16-20 weeks were included in the study and followed up to delivery and 6-7 weeks thereafter. Venous blood was collected at scheduled visit: Visit1 (V1; 16-20 weeks of amenorrhea), Visit2 (V2; 28 ±1 weeks of pregnancy), Visit3 (V3; 32 ±1 weeks of pregnancy), Visit4 (V4; delivery) and Visit5 (V5; 6-7 weeks after delivery). In addition, a cord blood sample was also collected at delivery. Nulliparous and primiparous/multiparous non-pregnant women were enrolled in the control group. Cortisol and prolactin plasma concentrations were measured using ichroma II and i-chamber apparatus. Light microscopy was used to detect Plasmodium falciparum infections. A linear mixed-effects regression (LMER) model was used to assess the association between the variation of cortisol titters and prolactin levels during the pregnancy and the post-partum. Results: Results showed that cortisol and prolactin levels in the peripheral blood were up-regulated during pregnancy. Concentrations of cortisol during follow-up was significantly higher in primigravidae than in multigravidae during the whole pregnancy (pConclusion: These results showed that the potential effects of cortisol and prolactin are related to gestational age. This could affect the susceptibility of pregnant women to infectious diseases such as malaria in endemic areas.

Representative H&E images of Ahnak-/- and WT lungs in embryonic day 18.5 and postnatal day 1.

AHNAK is known to be a tumor suppressor in breast cancer due to its ability to activate the TGFβ signaling pathway. However, the role of AHNAK in lung tumor development and progression remains unknown. Here, the Ahnak gene was disrupted to determine its effect on lung tumorigenesis and the mechanism by which it triggers lung tumor development was investigated. First, AHNAK protein expression was determined to be decreased in human lung adenocarcinomas compared with matched nonneoplastic lung tissues. Then, Ahnak−/− mice were used to investigate the role of AHNAK in pulmonary tumorigenesis. Ahnak−/− mice showed increased lung volume and thicker alveolar walls with type II pneumocyte hyperplasia. Most importantly, approximately 20% of aged Ahnak−/− mice developed lung tumors, and Ahnak−/− mice were more susceptible to urethane-induced pulmonary carcinogenesis than wild-type mice. Mechanistically, Ahnak deficiency promotes the cell growth of lung epithelial cells by suppressing the TGFβ signaling pathway. In addition, increased numbers of M2-like alveolar macrophages (AM) were observed in Ahnak−/− lungs, and the depletion of AMs in Ahnak−/− lungs alleviated lung hyperplastic lesions, suggesting that M2-like AMs promoted the progression of lung hyperplastic lesions in Ahnak-null mice. Collectively, AHNAK suppresses type II pneumocyte proliferation and inhibits tumor-promoting M2 alternative activation of macrophages in mouse lung tissue. These results suggest that AHNAK functions as a novel tumor suppressor in lung cancer.Implications: The tumor suppressor function of AHNAK, in murine lungs, occurs by suppressing alveolar epithelial cell proliferation and modulating lung microenvironment. Mol Cancer Res; 16(8); 1287–98. ©2018 AACR.

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In Chad, grilled meat has been well appreciated and consumed regularly. However, it could be the cause of many diseases if handled under unhygienic conditions. The objective of this study was to evaluate the microbiological quality and antimicrobial resistance profile of strains of Salmonella spp. and Escherichia coli isolated from grilled meat in the city of N'Djamena. Thirty producers were surveyed at least once from 02 August 2018 to 31 January 2019 and one grilled meat sample was collected from each of them. Total Mesophile Aerobic Flora (TMAF), Thermotolerant Coliform (TTC), Escherichia coli and Salmonella spp. counts, as well as susceptibility testing, were conducted at the Food and Nutrition Sciences Research Laboratory in N'Djamena according to standard methods. The level of the contamination of grilled meats was 83.33% for TMAF and 56.67% for TTC. The prevalence of Escherichia coli was 36.36%. Resistance was observed with some antibiotics especially those to the beta-lactam family. This study revealed that the grilled meat can expose the consumers to a sanitary risk. It should be stressed the strict application of good hygiene practices.

Integrated Library System (Inlis Lite) is used to facilitate library performance in maximizing service and assist the Library in finding information. The problem on the Inlis Lite website is difficult to access. This study uses the Webqual 4.0 method which focuses on 3 variables namely (usability, information qualit and service interaction) and Importance Performance Analysis (IPA) method. The results of teh Inlis Lite website quality analysis have a conformity rate 88,71% which means that the service is still not satisactory. The average GAP of -0,46 means that the quality of the Inlis Lite website still does not meet user expections. There are 4 indicators that need to be improved quality, namely US5, US7, SIQ5, and SIQ6 which are in the first quadrant

Gene therapy with LentiGlobin for sickle cell disease (bb1111, lovotibeglogene autotemcel) consists of autologous transplantation of a patient's hematopoietic stem cells transduced with the BB305 lentiviral vector that encodes the β

The synthesis of α-fluoroamines was achieved via deoxygenative geminal fluorosulfonimidation of 1,2-diketones using a dealkylation-resistant phosphoramidite under mild conditions that require neither excess reagents nor transition metal catalysts.

One type of deep foundation is a pile foundation that is designed and has the ability to withstand axial, lateral, and uplift loads. This analysis aims to determine and compare deflections that occur on poles that are in granular soil by using the manual calculation of the p-y curve method with finite difference approaches and calculations with Allpile and Plaxis software. The analysis was conducted three times, namely on a 60 cm diameter pole at a depth of 10 meters embedded pile with lateral loads of 25 kN, 50 kN, and 75 kN. The data used to calculate the lateral deflection of the pole is secondary data. Lateral deflection analysis using Plaxis software with a load of 25 kN, 50 kN, and 75 kN obtained lateral deflection of the uppermost pole respectively 0.159 cm, 0.324 cm, and 0.545 cm. Lateral deflection analysis using Allpile software with a load of 25 kN, 50 kN, and 75 kN obtained lateral deflection of the uppermost pile by 0.08 cm, 0.16 cm and 0.29 cm. While the results of the lateral deflection analysis of the manual calculation of the p-y curve method with a finite different up to 25 kN, 50 kN, and 75 kN loads obtained lateral deflection of the uppermost pile respectively by 0.60 cm, 0.12 cm and 0.179 cm. So the approximating calculations are manual calculation of the p-y curve method with calculations with Allpile software. Nash-Sutcliffe Efficiency (NSE) value calculation of the p-y curve method with plaxis software at lateral load 25 kN, 50 kN, 75 kN obtained consecutive NSE values of -5,946, -6,439, dan -30,118 all of which have unsatisfactory performance rating. Different with curve p-y method compared with Allpile that has consecutive NSE values of 0,876, 0,876, 0,876, dan 0,605 all of which have very good performance rating. ABSTRAKSalah satu jenis fondasi dalam adalah fondasi tiang yang didesain dan memiliki kemampuan untuk menahan beban aksial, lateral, dan uplift. Analisis ini bertujuan untuk mengetahui dan membandingkan defleksi yang terjadi pada tiang yang berada pada tanah granuler dengan menggunakan perhitungan manual metode kurva p-y dengan pendekatan beda hingga dan perhitungan dengan software Allpile dan Plaxis. Analisis dilakukan tiga kali percobaan yaitu pada tiang berdiameter 60 cm pada kedalaman tiang tertanam 10 meter dengan beban lateral sebesar 25 kN, 50 kN, dan 75 kN. Data yang dipakai untuk menghitung defleksi lateral tiang adalah data sekunder. Analisis defleksi lateral menggunakan software Plaxis dengan beban 25 kN, 50 kN, dan 75 kN didapatkan defleksi lateral tiang paling atas berturut-turut sebesar 0,159 cm, 0,324 cm, dan 0,545 cm. Analisis defleksi lateral menggunakan software Allpile dengan beban 25 kN, 50 kN, dan 75 kN didapatkan defleksi lateral tiang paling atas berturut-turut sebesar 0,08 cm, 0,16 cm, dan 0,29 cm. Sedangkan hasil analisis defleksi lateral perhitungan manual metode kurva p-y dengan pendekatan beda hingga dengan beban 25 kN, 50 kN, dan 75 kN didapatkan defleksi lateral tiang paling atas berturut turut sebesar 0,60 cm, 0,12 cm, dan 0,179 cm. Jadi perhitungan yang saling mendekati adalah perhitungan manual metode kurva p-y dengan perhitungan dengan software Allpile. Perhitungan nilai Nash-Sutcliffe Efficiency (NSE) metode kurva p-y dengan software Plaxis pada beban lateral 25 kN, 50 kN, dan 75 kN didapatkan nilai NSE berturut-turut sebesar -5,946, -6,493, dan -30,118 yang ketiganya memiliki rating performa tidak memuaskan. Berbeda dengan metode kurva p-y dibanding dengan Allpile memiliki nilai NSE berturut-turut sebesar 0,876, 0,876, dan 0,605 ketiganya mempunyai rating performa yang sangat baik.

Berbagai upaya untuk mengurangi penggunaan plastik sudah dilakukan, yakni dengan menggunakan metode 3R atau Recycle, Reuse, dan Reduce. Namun faktanya pengetahuan masyarakat terhadap upaya mengurangi penggunaan plastik masih kurang. Upaya untuk memahamkan ibu rumah tangga akan bahaya plastik merupakan salah satu solusi mengurangi penggunaan plastik. oleh karena itu, perlu dilakukan pelatihan pembuatan taman gantung sebagai salah satu solusi terhadap permasalahan di atas. Kegiatan pengabdian pada masyarakat ini bertujuan untuk meningkatkan pengetahuan dan keterampilan ibu-ibu Dasa Wisma Di RT 03 RW 11 Kelurahan Sukorejo Kecamatan Gunungpati Kota Semarang tentang pentingnya pemanfaatan barang bekas (plastik) sebagai bahan pembuatan taman gantung melalui metode pelatihan dan pendampingan. Materi pelatihan disampaikan dengan cara menerapkan metode ekspositori dan diskusi yang menerapkan daring melalui link zoom. Penyampaian materi dilengkapi dengan metode tutorial dengan pemberian umpan balik. Pada saat pembuatan taman gantung digunakan metode praktik yaitu ibu-ibu di ajak ke taman untuk diberikan pelatihan dan pendampingan dengan menerapkan protokol Kesehatan. Pengetahuan Ibu-ibu dasawisma peserta pelatihan dan pendampingan pembuatan taman gantung di RT 03 RW 11 di Kelurahan Sukorejo, Kecamatan Gunungpati, Kota Semarang mengalami peningkatan setelah diberikan pelatihan (metode ekspositori dan pendampingan) yaitu yang semula cenderung cukup dan baik menjadi sangat baik. Keterampilan Ibu-ibu dasawisma peserta pelatihan dan pendampingan pembuatan taman gantung di RT 03 RW 11 Kelurahan Sukorejo Kecamatan Gunungpati Kota Semarang setelah mendapatkan pendampingan praktik 30% dalam kategori sangat baik, sedangkan sisanya yaitu 70% dalam kategori baik. Abstract. Various efforts have been made to reduce the use of plastic, namely by using the 3R method or Recycle, Reuse, and Reduce. But the fact is that public knowledge about efforts to reduce the use of plastic is still lacking. Efforts to understand housewives about the dangers of plastic are one solution to reduce the use of plastic. Therefore, it is necessary to conduct training in making hanging gardens as a solution to the problems above. This community service activity aims to increase the knowledge and skills of Dasa Wisma housewives in RT 03 RW 11, Sukorejo Village, Gunungpati District, Semarang City about the importance of using used goods (plastic) as material for making hanging gardens through training and assistance methods. The training materials were delivered by applying the expository method and online discussions via the zoom link. The delivery of training materials was complemented by a tutorial method with feedback. At the time of making the hanging garden, a practical method was used, by inviting housewives to the park to be given training and assistance by implementing Health protocols. The knowledge of the Dasa Wisma housewives who participated in the training and assistance in making hanging gardens at RT 03 RW 11 in Sukorejo Village, Gunungpati District, Semarang City experienced an increase after being given training (expository and assistance methods) which initially tended to be quite and good to very good. The skills of the Dasawisma housewives who participated in the training and assistance in making hanging gardens at RT 03 RW 11, Sukorejo Village, Gunungpati District, Semarang City after receiving practical assistance, 30% were in the very good category, while the remaining 70% was in the good category.

Clustered regularly interspaced short palindromic repeats/CRISPR associated nuclease 9 (CRISPR-Cas9) system was instigated first into eukaryotes in the last ten years are becoming productive and worldwide application for genome modification. Genome engineering through insertion of foreign DNA insert have numerous disadvantages which could be overcome by use of DNA-free genome editing. Various ways of DNA-free genome editing mediated by CRISPR/Cas systems are CRISPR/Cas delivery as ribonucleoprotein, delivery of CRISPR/Cas as virus-like particles and agrobacterium-based delivery of CRISPR/Cas. Crop improvement through DNA-free genome editing via CRISPR/Cas have been applied in rice, wheat, maize, tomato, soybean and rare species like Nicotiana benthamiana etc. It is method of choice for precise genome editing without genome shuffle in an organism.

El sector de la salud está experimentando un importante crecimiento en la oferta de servicios, pero esta no está siendo suficiente para cubrir la demanda actual. La accesibilidad a los prestadores de servicios médicos es importante y los usuarios se quejan de la escasa oportunidad de citas por medicina especializada, de acuerdo a datos de la Superintendencia Nacional de Salud. Por otro lado, el estado colombiano tiene la responsabilidad de vigilar, controlar y promulgar leyes para crear condiciones dignas para el derecho a la salud, y delega los servicios de salud al sector público y privado. El principal desafío en el sector de la salud es garantizar un acceso adecuado y oportuno a los servicios y atención médica especializada, pero esto se ve obstaculizado por factores como la falta de infraestructura adecuada para la gestión de citas médicas y la escasez de especialistas en algunas áreas. La pandemia de COVID-19 ha empeorado aún más estos problemas de acceso. Es importante buscar soluciones para mejorar el acceso a citas por especialistas y mejorar la atención médica para los pacientes. Con base en esta información, se va a proponer un plan de mejora para la calidad y oportunidad de citas por medicina interna en una IPS de Puerto Carreño, Vichada. Especialización Especialista en Gerencia de la Salud

Animal-source foods (ASF) provide nutrition for children and adolescents’ physical and cognitive development. Here, we use data from the Global Dietary Database and Bayesian hierarchical models to quantify global, regional and national ASF intakes between 1990 and 2018 by age group across 185 countries, representing 93% of the world’s child population. Mean ASF intake was 1.9 servings per day, representing 16% of children consuming at least three daily servings. Intake was similar between boys and girls, but higher among urban children with educated parents. Consumption varied by age from 0.6 at

Résumé : L'onomatopée et l’idéophone, fabrications imitatives de mots à partir de sons, sont des phénomènes courants que l'on retrouve dans toutes les langues du monde. L'étude des onomatopées et des idéophones est cependant insuffisante au regard d’une perspective contrastive notamment entre les langues occidentales et Africaines. Compte tenu de son importance dans le développement du langage, la présente étude fournit un compte rendu descriptif des onomatopées et des idéophones de deux (2) différentes langues à savoir l’Anglais et le Gouro. Quelles sont les structures morphologiques et syntaxiques des Idéophones et onomatopées du gouro et de l’anglais ? Mieux, les structures morphologiques et syntaxiques des idéophones et onomatopées du gouro sont-elles semblables à celles de l’anglais ? Cet article met en exergue les structures morphologique et syntaxique des onomatopées et idéophones de l’Anglais et du Gouro (langue mandé sud de Côte d’Ivoire). L’objectif est de rendre compte des similitudes et des différences entre ces deux phénomènes linguistiques. Il a été découvert qu’il existe une relation de similarité morphosyntaxique élevée entre les onomatopées et les idéophones de l’anglais et du Gouro, mais aussi il faut noter qu’une différence en partie existe dans certains cas. Mots-clés : Onomatopées, Idéophones, Gouro, morphologie, structure, syntaxe