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445 results on '"Zissis G"'

211. Clinical Transplantation of Individualized Recipient Serum-Adapted Cornea Reduces the Risk of Graft Rejection after Keratoplasty

Author

Solon Thanos, Zissis Gatzioufas, Maurice Schallenberg, Simone König, Hans-Werner Meyer-Rüsenberg, and Holger Busse

Subjects
Medicine
Abstract

Corneal diseases cause severe visual impairment that necessitates corneal transplantation and frequently repetitive procedures due to graft rejection. We tested the hypothesis that exposure of donor corneas to recipient serum-derived factors during eye banking triggers a preoperative adaptation that is beneficial for postoperative tolerance. Donor corneas were incubated in a medium containing human serum (HS) obtained in each case from the prospective graft recipient in order to individually expose the donor cornea to the recipient's serum. All recipient serum-adapted corneas (RSACs) fulfilled the clinical criteria required by the national law and were transplanted successfully. The postoperative ophthalmological examination extended up to 8 years. All RSACs were tolerated by their recipients and did not cause postoperative complications and no rejection. Proteomic analysis of corneas cultivated in culture medium containing either fetal calf serum (FCS) that is routinely used for cornea banking or HS revealed different patterns of proteins. HS-cultured corneas showed a greater proteomic similarity with native human corneas than did the FCS-cultured corneas, indicating a differential nutrification of the cultured corneal tissue by HS-derived factors. The clinical results show for the first time that postoperative complications such as tissue intolerance and graft rejection might be managed if the corneal tissue is individually adapted to the recipient's serum trophic factors. This new donor tissue treatment procedure offers incontrovertible advantages and could be adapted for low-risk eyes as well as other transplantable tissues.

Published
2013
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213. Comparative evaluation of NASBA HIV-1 RNA QT, AMPLICOR-HIV monitor; and QUANTIPLEX HIV RNA assay, three methods for quantification of human immunodeficiency virus type 1 RNA in plasma

Author

Revets, H., Marissens, D., Dewit, S., Lacor, P., Clumeck, N., Lauwers, S., and Zissis, G.

Subjects
HIV infection -- Diagnosis, RNA -- Measurement
Abstract

According to the authors' abstract of an article published in Journal of Clinical Microbiology, "Three commercial assays for quantifying plasma human immunodeficiency virus type 1 (HIV-1) RNA were evaluated. The [...]

Published
1996

248. Critical Use of Nucleic Acid Amplification Techniques To Test for Mycobacterium tuberculosisin Respiratory Tract Samples

Author

Van den Wijngaert, S., Dediste, A., VanLaethem, Y., Gerard, M., Vandenberg, O., and Zissis, G.

Abstract

ABSTRACTThe usefulness of employing Belgian selection criteria before performing nucleic acid amplification techniques (NAT) was evaluated. The results of this study show that for smear-negative patients with an abnormal chest radiology result in the absence of a respiratory tract infection by bacterial pathogens, testing with NAT is of major benefit.

Published
2004
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250. New Study of 'Flicker' in Lamps.

Author

Kitsinelis, S. and Zissis, G.

Subjects
LIGHT emitting diodes, LAMPS, LIGHTING
Abstract

The article presents an overview of a study of flicker in flourescents and light emitting diode (LED) lamps and their potential impact on the health of people by S. Kitsineis and G. Zissis.

Published
2012

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