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674 results on '"d'Enfert, Christophe"'

202. Genetic Diversity among Korean Candida albicans Bloodstream Isolates: Assessment by Multilocus Sequence Typing and Restriction Endonuclease Analysis of Genomic DNA by Use of BssHII

Author

Shin, Jong Hee, primary, Bougnoux, Marie-Elisabeth, additional, d'Enfert, Christophe, additional, Kim, Soo Hyun, additional, Moon, Chang-Jin, additional, Joo, Min Young, additional, Lee, Kyungwon, additional, Kim, Mi-Na, additional, Lee, Hye Soo, additional, Shin, Myung Geun, additional, Suh, Soon Pal, additional, and Ryang, Dong Wook, additional

Published
2011
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207. A β-glucan-conjugate vaccine and anti-β-glucan antibodies are effective against murine vaginal candidiasis as assessed by a novel in vivo imaging technique

Author

Pietrella, Donatella, primary, Rachini, Anna, additional, Torosantucci, Antonella, additional, Chiani, Paola, additional, Brown, Alistair J.P., additional, Bistoni, Francesco, additional, Costantino, Paolo, additional, Mosci, Paolo, additional, d’Enfert, Christophe, additional, Rappuoli, Rino, additional, Cassone, Antonio, additional, and Vecchiarelli, Anna, additional

Published
2010
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208. Comparative Transcript Profiling of Candida albicans and Candida dubliniensis Identifies SFL2 , a C. albicans Gene Required for Virulence in a Reconstituted Epithelial Infection Model

Author

Spiering, Martin J., primary, Moran, Gary P., additional, Chauvel, Murielle, additional, MacCallum, Donna M., additional, Higgins, Judy, additional, Hokamp, Karsten, additional, Yeomans, Tim, additional, d'Enfert, Christophe, additional, Coleman, David C., additional, and Sullivan, Derek J., additional

Published
2010
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215. The Yak1 Kinase Is Involved in the Initiation and Maintenance of Hyphal Growth inCandida albicans

Author

Goyard, Sophie, primary, Knechtle, Philipp, additional, Chauvel, Murielle, additional, Mallet, Adeline, additional, Prévost, Marie-Christine, additional, Proux, Caroline, additional, Coppée, Jean-Yves, additional, Schwarz, Patrick, additional, Dromer, Françoise, additional, Park, Hyunsook, additional, Filler, Scott G., additional, Janbon, Guilhem, additional, and d'Enfert, Christophe, additional

Published
2008
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217. Multilocus Sequence Typing Reveals that the Population Structure of Candida dubliniensis Is Significantly Less Divergent than That of Candida albicans

Author

McManus, Brenda A., primary, Coleman, David C., additional, Moran, Gary, additional, Pinjon, Emmanuelle, additional, Diogo, Dorothée, additional, Bougnoux, Marie-Elisabeth, additional, Borecká-Melkusova, Silvia, additional, Bujdákova, Helena, additional, Murphy, Philip, additional, d'Enfert, Christophe, additional, and Sullivan, Derek J., additional

Published
2008
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219. Molecular Phylogenetics of Candida albicans

Author

Odds, Frank C., primary, Bougnoux, Marie-Elisabeth, additional, Shaw, Duncan J., additional, Bain, Judith M., additional, Davidson, Amanda D., additional, Diogo, Dorothée, additional, Jacobsen, Mette D., additional, Lecomte, Maud, additional, Li, Shu-Ying, additional, Tavanti, Arianna, additional, Maiden, Martin C. J., additional, Gow, Neil A. R., additional, and d'Enfert, Christophe, additional

Published
2007
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220. Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88

Author

Pel, Herman J, primary, de Winde, Johannes H, additional, Archer, David B, additional, Dyer, Paul S, additional, Hofmann, Gerald, additional, Schaap, Peter J, additional, Turner, Geoffrey, additional, de Vries, Ronald P, additional, Albang, Richard, additional, Albermann, Kaj, additional, Andersen, Mikael R, additional, Bendtsen, Jannick D, additional, Benen, Jacques A E, additional, van den Berg, Marco, additional, Breestraat, Stefaan, additional, Caddick, Mark X, additional, Contreras, Roland, additional, Cornell, Michael, additional, Coutinho, Pedro M, additional, Danchin, Etienne G J, additional, Debets, Alfons J M, additional, Dekker, Peter, additional, van Dijck, Piet W M, additional, van Dijk, Alard, additional, Dijkhuizen, Lubbert, additional, Driessen, Arnold J M, additional, d'Enfert, Christophe, additional, Geysens, Steven, additional, Goosen, Coenie, additional, Groot, Gert S P, additional, de Groot, Piet W J, additional, Guillemette, Thomas, additional, Henrissat, Bernard, additional, Herweijer, Marga, additional, van den Hombergh, Johannes P T W, additional, van den Hondel, Cees A M J J, additional, van der Heijden, Rene T J M, additional, van der Kaaij, Rachel M, additional, Klis, Frans M, additional, Kools, Harrie J, additional, Kubicek, Christian P, additional, van Kuyk, Patricia A, additional, Lauber, Jürgen, additional, Lu, Xin, additional, van der Maarel, Marc J E C, additional, Meulenberg, Rogier, additional, Menke, Hildegard, additional, Mortimer, Martin A, additional, Nielsen, Jens, additional, Oliver, Stephen G, additional, Olsthoorn, Maurien, additional, Pal, Karoly, additional, van Peij, Noël N M E, additional, Ram, Arthur F J, additional, Rinas, Ursula, additional, Roubos, Johannes A, additional, Sagt, Cees M J, additional, Schmoll, Monika, additional, Sun, Jibin, additional, Ussery, David, additional, Varga, Janos, additional, Vervecken, Wouter, additional, van de Vondervoort, Peter J J, additional, Wedler, Holger, additional, Wösten, Han A B, additional, Zeng, An-Ping, additional, van Ooyen, Albert J J, additional, Visser, Jaap, additional, and Stam, Hein, additional

Published
2007
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231. Membrane protective role of autophagic machinery during infection of epithelial cells by Candida albicans

Author

Lapaquette, Pierre, Ducreux, Amandine, Basmaciyan, Louise, Paradis, Tracy, Bon, Fabienne, Bataille, Amandine, Winckler, Pascale, Hube, Bernhard, d’Enfert, Christophe, Esclatine, Audrey, Dubus, Elisabeth, Bringer, Marie-Agnès, Morel, Etienne, and Dalle, Frédéric

Abstract

ABSTRACTCandida albicans(C. albicans) is an opportunistic pathogen causing infections ranging from superficial to life-threatening disseminated infections. In a susceptible host, C. albicansis able to translocate through the gut barrier, promoting its dissemination into deeper organs. C. albicanshyphae can invade human epithelial cells by two well-documented mechanisms: epithelial-driven endocytosis and C. albicans-driven active penetration. One mechanism by which host cells protect themselves against intracellular C. albicansis termed autophagy. The protective role of autophagy during C. albicansinfection has been investigated in myeloid cells; however, far less is known regarding the role of this process during the infection of epithelial cells. In the present study, we investigated the role of autophagy-related proteins during the infection of epithelial cells, including intestinal epithelial cells and gut explants, by C. albicans. Using cell imaging, we show that key molecular players of the autophagy machinery (LC3-II, PI3P, ATG16L1, and WIPI2) were recruited at Candidainvasion sites. We deepened these observations by electron microscopy analyses that reveal the presence of autophagosomes in the vicinity of invading hyphae. Importantly, these events occur during active penetration of C. albicansinto host cells and are associated with plasma membrane damage. In this context, we show that the autophagy-related key proteins ATG5 and ATG16L1 contribute to plasma membrane repair mediated by lysosomal exocytosis and participate in protecting epithelial cells against C. albicans-induced cell death. Our findings provide a novel mechanism by which epithelial cells, forming the first line of defense against C. albicansin the gut, can react to limit C. albicansinvasion.

Published
2022
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237. Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatusboth in Monotherapy and in Combination with Caspofungin

Author

Laskaris, Paris, Atrouni, Ahmad, Calera, José Antonio, d'Enfert, Christophe, Munier-Lehmann, Hélène, Cavaillon, Jean-Marc, Latgé, Jean-Paul, and Ibrahim-Granet, Oumaïma

Abstract

ABSTRACTAspergillus fumigatuscan infect immunocompromised patients, leading to high mortality rates due to the lack of reliable treatment options. This pathogen requires uptake of zinc from host tissues in order to successfully grow and cause virulence. Reducing the availability of that micronutrient could help treat A. fumigatusinfections. In this study, we examined the in vitroeffects of seven chelators using a bioluminescent strain of A. fumigatus. 1,10-Phenanthroline and N,N,N′,N′-tetrakis(2-pyridylmethyl)ethane-1,2-diamine (TPEN) proved to be the chelators most effective at inhibiting fungal growth. Intraperitoneal administration of either phenanthroline or TPEN resulted in a significant improvement in survival and decrease of weight loss and fungal burden for immunosuppressed mice intranasally infected with A. fumigatus. In vitroboth chelators had an indifferent effect when employed in combination with caspofungin. The use of TPEN in combination with caspofungin also significantly increased survival compared to that when using these drugs individually. Our results suggest that zinc chelation may be a valid strategy for dealing with A. fumigatusinfections and that both phenanthroline and TPEN could potentially be used either independently or in combination with caspofungin, indicating that their use in combination with other antifungal treatments might also be applicable.

Published
2016
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238. Genetic Diversity Among Candida albicans Isolates Associated with Vertical Transmission in Preterm Triplets.

Author

Hoarau, Gautier, Bougnoux, Marie-Elisabeth, Fily, Antoine, François, Nadine, Loridant, Séverine, Jawhara, Samir, d'Enfert, Christophe, Poulain, Daniel, and Sendid, Boualem

Abstract

We report a case of congenital candidiasis in triplets, in the context of premature labor at 25 weeks gestation, without symptomatic vaginitis or chorioamnionitis. All three infants died as a result of prematurity, aggravated by systemic candidiasis. Multi-locus sequence typing confirmed vertical transmission of Candida albicans from the mother to the triplets and revealed a slight diversity among the strains isolated from the neonates. [ABSTRACT FROM AUTHOR]

Published
2014
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239. A study of the DNA damage checkpoint in Candida albicans: uncoupling of the functions of Rad53 in DNA repair, cell cycle regulation and genotoxic stress-induced polarized growth.

Author

Loll‐Krippleber, Raphaël, d'Enfert, Christophe, Feri, Adeline, Diogo, Dorothée, Perin, Aurélie, Marcet‐Houben, Marina, Bougnoux, Marie‐Elisabeth, and Legrand, Mélanie

Subjects
*DNA damage, *CANDIDA albicans genetics, *DNA repair, *CELL cycle regulation, *GENETIC toxicology, *HETEROZYGOSITY, *ENZYME regulation, *ANEUPLOIDY
Abstract

In response to genotoxic stress ( GS), Candida albicans can undergo polarized growth and massive genome rearrangements including loss-of-heterozygosity ( LOH) events. We evaluated the contribution of the CaRad53p and CaDun1p kinases of the DNA damage checkpoint ( DDCP) in these processes. Characterization of C. albicans rad53 ΔΔ and dun1 ΔΔ mutants revealed that the two kinases were involved in the maintenance of heterozygosity. SNP- RFLP typing and whole-genome sequencing of rad53 ΔΔ isolates having undergone a LOH revealed that, according to the chromosome on which LOH had occurred, these were predominantly due to break-induced replication/mitotic cross-over or chromosome loss. Loss of CaRAD53 also resulted in frequent aneuploidies. Deletion of CaDUN1 led to an increase in recombination-dependent LOH but did not trigger aneuploidies. It also increased GS sensitivity but did not impair GS-induced polarized growth contrary to CaRAD53 deletion. Characterization of CaRad53p site-directed mutants demonstrated that its kinase activity and N-terminal phosphorylation sites were crucial for its function in the resistance to GS, maintenance of heterozygosity, cell cycle regulation and polarized growth. Moreover, using phosphomimic mutants, we revealed an uncoupling of the functions of CaRad53p in these different processes, thus providing a novel understanding of how the DDCP may regulate downstream events in response to GS. [ABSTRACT FROM AUTHOR]

Published
2014
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240. Microbiology

Author

Blocker, Ariel, primary, Peppler, Mark S, additional, Stock, Jeff, additional, Normand, Philippe, additional, Grimont, Francine, additional, d’Enfert, Christophe, additional, Rosenthal, Kenneth L, additional, Sibley, David, additional, Labedan, Bernard, additional, Forterre, Patrick, additional, O’Neill, Alex, additional, Storey, Chris, additional, Casselton, Lorna, additional, and Errington, Jeff, additional

Published
1999
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246. A protocol for ultrastructural study of Candida albicansbiofilm using transmission electron microscopy

Author

Mourer, Thierry, Sachse, Martin, Gazi, Anastasia D., d’Enfert, Christophe, and Bachellier-Bassi, Sophie

Abstract

This protocol describes how to analyze C. albicansbiofilm using transmission electron microscopy. We present two approaches to observe the ultrastructure of fungal cells within unperturbed biofilms, as well as an immunogold labeling procedure. This approach maintains the architecture of the fungal biofilm close to its native state by growing C. albicansbiofilm on a plastic surface. After the freeze substitution procedure, classical transmission electron microscopy or electron tomography will allow the ultrastructural analysis of the microbial community.

Published
2022
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250. Candida albicans Is Not Always the Preferential Yeast Colonizing Humans: A Study in Wayampi Amerindians.

Author

Angebault, Cécile, Djossou, Félix, Abélanet, Sophie, Permal, Emmanuelle, Ben Soltana, Mouna, Diancourt, Laure, Bouchier, Christiane, Woerther, Paul-Louis, Catzeflis, François, Andremont, Antoine, d'Enfert, Christophe, and Bougnoux, Marie-Elisabeth

Subjects
CANDIDA albicans, YEAST, INTESTINES, SACCHAROMYCES cerevisiae, GENOMICS, INDIGENOUS peoples of the Americas
Abstract

In industrialized countries Candida albicans is considered the predominant commensal yeast of the human intestine, with approximately 40% prevalence in healthy adults. We discovered a highly original colonization pattern that challenges this current perception by studying in a 4- year interval a cohort of 151 Amerindians living in a remote community (French Guiana), and animals from their environment. The prevalence of C. albicans was persistently low (3% and 7% of yeast carriers). By contrast, Candida krusei and Saccharomyces cerevisiae were detected in over 30% of carriers. We showed that C. krusei and S. cerevisiae carriage was of food or environmental origin, whereas C. albicans carriage was associated with specific risk factors (being female and living in a crowded household). We also showed using whole-genome sequence comparison that C. albicans strains can persist in the intestinal tract of a healthy individual over a 4-year period. [ABSTRACT FROM AUTHOR]

Published
2013
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