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Individuals with primary or secondary abnormalities of iron metabolism, such as hereditary hemochromatosis and transfusional iron loading, may develop potentially lethal systemic iron overload. Over time, this excess iron is progressively deposited in the liver, heart, pancreas, and other organs, resulting in cirrhosis, heart disease, diabetes and other disorders. Unless treated, death usually results from cardiac failure. The amount of iron in the liver is the best indicator of the amount of iron in the whole body. At present, the only sure way to measure the amount of iron in the liver is to remove a sample of the liver by biopsy. Iron stored in the liver can be magnetized to a small degree when placed in a magnetic field. The amount of magnetization is measured by our instrument, called a superconducting quantum interference device (SQUID) susceptometer. In patients with iron overload, our previous studies have shown that magnetic measurements of liver iron in patients with iron overload are quantitatively equivalent to biochemical determinations on tissue obtained by biopsy. The safety, ease, rapidity, and comfort of magnetic measurements make frequent, serial studies technically feasible and practically acceptable to patients. [ABSTRACT FROM AUTHOR]

Objective: The aim of this study was to compare clinically relevant performance of: 1) a prototype respiratory sensor based on capnometry with two alternative signal receptor fixations, 2) a fiberoptic humidity sensor and 3) human visual observation. Comparative provocation tests were performed on volunteers at the Post-Anesthesia Care Unit at Västerås Central Hospital.Methods: The experimental tests involved 10 healthy, voluntary test subjects, instructed to intersperse normal breathing with protocol provocations of breath holding, limb and head movements, and nasal oxygen supplement. The signal outputs from the three respiratory monitoring methods were recorded on a personal computer. The signal analysis included visual categorising of the signals and counting breath events. Recognising that none of the methods could act as reference, events were classified as "unanimous," "majority" or "minority" events depending on how many of the three methods that detected a breath.Results: The average total recording time was 37 minutes per subject. The respiratory rates varied from 6.5 to 19 breaths per minute, with a mean value of 11.4 breaths/minute. The breath hold duration ranged from 18 to 50 seconds. Discrepancies between the three methods were found in more than 20% of the marked events. The most frequent majority events were due to events not recorded by the observer who, on the other hand, contributed the least to minority events. The provocations made by the subjects during the measurement did not increase the rates of majority and minority events, compared to periods of no provocation. The fiberoptic device exhibited a larger count of minority events but a smaller contribution to majority events than the capnometry prototype.Conclusions: The capnometry and fiberoptic sensors exhibit differences in responses that may be understood from basic principles. The importance of the physical application of the sensor to the patient was clearly observed. The optimum design remains to be found. [ABSTRACT FROM AUTHOR]

Objective: Photoplethysmography (PPG) is a non-invasive optical technique that measures variations in skin blood volume and perfusion. The PPG signal contains components that are synchronous with respiratory and cardiac rhythms. We undertook this study to evaluate PPG for monitoring patients' respiratory rate in the postoperative care unit, using a new prototype device. We compared it with the established technique, transthoracic impedance (TTI).Methods: PPG signals from 16 patients (ASA classes 1-2, mean age 43 years) who were recovering from general anaesthesia after routine operations were recorded continuously for 60 minutes/patient. The respiratory synchronous part of the PPG signal was extracted by using a bandpass filter. Detection of breaths in the filtered PPG signals was done both visually and by using an automated algorithm. In both procedures, the detected breaths were compared with the breaths detected in the TTI reference.Results: A total of 10,661 breaths were recorded, and the mean +/- SD respiratory rate was 12.3 +/- 3.5 breaths/minute. When compared with TTI, the rates of false positive and false negative breaths detected by PPG (visual procedure) were 4.6 +/- 4.5% and 5.8 +/- 6.5%, respectively. When using the algorithm for breath detection from PPG, the rates of false positive and false negative breaths were 11.1 +/- 9.7% and 3.7 +/- 3.8%, respectively, when compared to TTI. Lower respiratory rates increased the occurrence of false-positive breaths that were detected by the PPG using visual identification (p < 0.05). The same tendency was seen with the automated PPG procedure (p < 0.10).Conclusions: Our results indicate that PPG has the potential to be useful for monitoring respiratory rate in the postoperative period. [ABSTRACT FROM AUTHOR]

Intra-abdominal hypertension, defined as an intra-abdominal pressure (IAP) equal to or above 12 mmHg is one of the major risk-factors for increased morbidity (organ failure) and mortality in critically ill patients. Therefore, IAP monitoring is highly recommended in intensive care unit (ICU) patients to predict development of abdominal compartment syndrome and to provide a better care for patients hospitalized in the ICU. The IAP measurement through the bladder is the actual reference standard advocated by the abdominal compartment society; however, this measurement technique is cumbersome, non-continuous, and carries a potential risk for urinary tract infections and urethral injury. Using microwave reflectometry has been proposed as one of the most promising IAP measurement alternatives. In this study, a novel radar-based method known as transient radar method (TRM) has been used to monitor the IAP in an in vitro model with an advanced abdominal wall phantom. In the second part of the study, further regression analyses have been done to calibrate the TRM system and measure the absolute value of IAP. A correlation of –0.97 with a p-value of 0.0001 was found between the IAP and the reflection response of the abdominal wall phantom. Additionally, a quadratic relation with a bias of −0.06 mmHg was found between IAP obtained from the TRM technique and the IAP values recorded by a pressure gauge. This study showed a promising future for further developing the TRM technique to use it in clinical monitoring. [ABSTRACT FROM AUTHOR]

Objective.A new photoplethysmographic (PPG) device for respiratoryand heart rate monitoring has been evaluated in the neonatal care units at theUniversity Children's Hospital of Uppsala, Sweden. The purpose of thisstudy was to compare this new device with more established techniques, i.e.,transthoracic impedance plethysmography (TTI) for monitoring of respiratoryrate and ECG for heart rate monitoring. Methods.Data were acquiredcontinuously for 8-hours in each of 6 neonates. The signals were analysed forperiods of 30 seconds, in which the heart and respiratory signals from the PPGdevice were compared with the ECG and the impedance plethysmogram. Results.The ECG recordings were of high quality in 77% of the analysed periods.In these periods, excluding periods (6%) disturbed by offset-adjustement ofthe PPG signal, the PPG heart signal included 1.1% (±0.7% SD) falsenegative beats and 0.9% (±0.6%) false positive beats. In periods withan impedance signal of high quality (29% of total time), the part of the PPGsignal synchronous with respiration included 2.7% (±1.1%) falsenegative breaths and 1.5% (±0.4%) false positive breaths. Here, 2% ofthe periods were discarded because of offset-adjustment. From the periods oflow signal quality, two other conclusions were drawn: 1) The impedance signalcontains more power in the respiratory range than the corresponding PPGrespiratory signal. 2) The breaths are easier to identify in the PPGrespiratory signal than in the impedance signal (subjective measure). Conclusions.Electrode and motion artefacts seem to disturb the ECGsignals and, particularly, the impedance signals. During periods of highquality ECG and impedance signals, the new optical device produces signals ofequal quality to these traditional methods, and is in some cases even better.The new device is non-invasive and has a small optical probe. These factorsindicate further advantages of the photoplethysmographic method. [ABSTRACT FROM AUTHOR]

Previous noninvasive studies of the mean heart rate of embryonic birds have prompted an investigation into the instantaneous heart rate (IHR), which may be informative in developmental studies of cardiac rhythm. Using the acoustocardiogram (ACG), a noninvasive, long-term measuring system for embryonic IHR is developed, and the IHR in chickens during the last half of embryonic development is determined. The system, which uses a micro-computer, samples the ACG at a frequency of 50 Hz, restores the ACG wave by sinc function and calculates the IHR with an error in accuracy of less than 1 beat min-1. It was found that characteristic, transient bradycardia begins to appear late in the second week of incubation, and, with the additional development of transient tachycardia, the embryonic cardiac rhythm becomes more arrhythmic towards hatching. Simultaneous measurements of IHR with somatic movements showed no relationship between arrhythmia and embryonic activities. This system is useful, providing new evidence on long-term IHR developmental patterns. [ABSTRACT FROM AUTHOR]

A portable instrument, based on a volume-compensation technique, is designed for ambulatory monitoring of indirect beat-to-beat blood pressure (BP) in the superficial temporal artery. The instrument consists of a small disc-type cuff and a portable unit carried by the subject. Several components are integrated in the cuff for applying counter-pressure to the artery, i.e. a reflectance-type photo-plethysmographic sensor for arterial volume detection, a pressure sensor for cuff pressure Pc measurement and a nozzle flapper-type- electro-pneumatic convertor for controlling Pc. The portable unit includes volume servo control circuitry and a microprocessor-based signal-processing and recording unit. This automatically performs all the necessary measurement procedures and stores into a memory IC element the processed systolic, mean and diastolic blood pressure data, together with pulse intervals on a beat-to-beat basis from the servo-controlled Pc (indirectly measured BP waveform). With this instrument, momentary changes in BP during ambulatory situations such as bicycle ergometer exercise and daily activities including motorway driving are successfully recorded. From the results of simultaneous measurement of the subject's posture changes, the effect of posture change on blood pressure, e.g. baroreceptor-cardiac reflex, is also clearly demonstrated. [ABSTRACT FROM AUTHOR]

The effects of exercise on gastric emptying remain controversial, with some workers reporting that heavy exercise inhibits it to varying degrees whereas others report no effects up to an intensity of 70% maximal oxygen consumption ( O2max). The state of hydration of the subjects and the environmental conditions may influence the rate of gastric emptying during exercise. To understand further the effects of a 3-h, 16-km walk/run carrying 30 kg of equipment under field conditions at 39°C, we estimated gastric emptying using a [13C]acetate breath test method. Breath samples were collected at intervals after giving 150 mg of [13C]acetate. The effects of giving a standard volume (530 ml) of water or dextrose (7.5 g · 100 ml−1) with electrolytes or fructose/corn solids (7.5 g · 100 ml−1) at rest before exercise were compared with those of exercise and of recovery after exercise with or without extra fluids (400 ml each 20 min). At rest, after a standard 530-ml load, gastric emptying times [mean (SE)] were: 37 (2) min (water), 46 (3) min (dextrose/electrolytes) and 47 (5) min (fructose/corn solids) and were significantly slower ( P < 0.05) than those occurring after extra fluid ingestion, i.e. 32 (3), 39 (2) and 41 (3) min respectively. After a standard 530-ml load, emptying times during exercise were almost identical to those at rest but, during exercise, extra fluid speeded up gastric emptying more than at rest to 24 (2), 26 (1) and 27 (5) min ( P < 0.05) respectively. During resting recovery without extra fluids, gastric emptying was significantly slowed to 60 (2), 71 (5) and 78 (3) min, respectively. Although emptying times during recovery from exercise with extra fluid were faster [49 (6), 55 (2) and 58 (4) min, respectively], they were still slower than before exercise. The results suggest that: (1) extra fluid increases gastric emptying more during exercise than at rest, and (2) gastric emptying during resting recovery from exercise is slower than at rest before exercise whether or not fluid has previously been taken. [ABSTRACT FROM AUTHOR]

Relating eye size differences in birds to aspects of ecology and life history features offers interesting views on selective forces shaping eye size. However, data on eye size is hardly available. We compare two non-invasive methods for measuring the eye sizes of live birds: measures obtained using photos with a scale of the heads of mist-netted birds and published data based on measurements using a caliper. Both methods produced nearly identical data. Hence, we recommend using photos for measuring eye size instead of using a caliper, thereby-amongst other advantages-minimizing the risk of damaging the bird's eye. [ABSTRACT FROM AUTHOR]

• First fouling measurement at industrially relevant cross flow rate using NMR. • NMR signal correlates with alginate dosing, thus quantifying foulant accumulation. • T 2, eff MRI shows that the alginate accumulates at spacer nodes, confirmed by autopsy. • Rapid velocity imaging of the subtle effect of fouling in operating SWRO modules. A novel magnetic resonance measurement (MRM) protocol for non-invasive monitoring of fouling in spiral wound reverse osmosis (SWRO) membrane modules is demonstrated. Sodium alginate was used to progressively foul a commercial SWRO membrane at industrially relevant operating conditions in a circulating flow loop. The MRM protocol showcased the following: (i) earlier, more sensitive detection and quantification of fouling in the membrane module compared to feed-channel pressure drop. This was achieved using appropriate detection of the total nuclear magnetic resonance (NMR) signal. (ii) 2D cross-sectional imaging of the location of the accumulated foulant material; this was preferentially located adjacent to the membrane spacer sheet nodes, which was subsequently confirmed by a module autopsy. This image contrast, which could also readily differentiate the membrane, feed spacer and permeate spacer regions, was realised based on differences in the NMR relaxation parameter, T 2,eff. (iii) High frequency acquisition of 2D cross-sectional velocity images of the module revealing very localised flow channelling in response to gradual foulant accumulation which impacted significantly on the flow pattern within the central permeate tube. Collectively this NMR/MRI measurement protocol provides a powerful analysis tool for the evolution of fouling in such complex modules, thus ultimately enabling more informed module design. [Display omitted] [ABSTRACT FROM AUTHOR]

• Two cells of split ring resonators are used to improve the electromagnetic interaction between the sensor and water/Glucose. • Water/Glucose is simulated in Comsol using a realistic model. • Return loss is a useful parameter for determining glucose level in water for this sensor. • Electronic prototype is proposed to improve the sensitivity at an optimal frequency. A microwave sensor for glucose concentration measurement is presented. The proposed sensor is composed of two cells of circular split ring resonator (SRR) with a liquid holder put on both cells. Those resonators are coupled to a coplanar line forming a two-port network whose S-parameter response provide an information about the dielectric properties of the liquid that is under study. This paper presents a numerical simulation and experimental study of our new configuration of the resonators to assess the sensitivity of the sensor toward small change in glucose concentrations in water. An electronic prototype has been used to improve the detection; a resolution of 1.665 mmol/l is reached at the frequency 1.9 GHz. The obtained results have shown the effectiveness of this new configuration of resonators sensor for non-invasive measurement on the small change in dielectric parameter ε r. Therefore, the proposed sensor is well fitted for real time measurement, non-destructive, precise, and low cost. [ABSTRACT FROM AUTHOR]

In this study, partial least square (PLS) regression models were developed to predict moisture content (MC) (model 1), CIELAB color (model 2) or all four parameters (model 3) of beef slices during drying. Model development was based on data from two measurement campaigns of MC (%), CIELAB L*, a* and b*values and hyperspectral data in the range of 500–1009 nm. To increase the robustness of the models, the beef samples varied dependent on cattle breed, cut and pre-treatment. With low-cost, non-invasive continuous monitoring systems in mind, the models were simplified by wavelengths selection. The Deming and Passing-Bablok regression and the Bland-Altman plot revealed high model performances. Mean differences (full/reduced model) of −0.64/-0.64 for MC, −0.14/-0.15 for CIELAB L*, 0.05/0.04 for a* and 0.08/0.06 for b* values were achieved for model 3, which shows the high potential for simple real-time monitoring applications combining all investigated factors and parameters. • Robust models for spectral measurements of moisture and color during drying of beef. • High accordance between spectral and laboratory measurements. • Simplified high performance models by selection of maximum ten wavelengths. • High potential of simple non-invasive spectral monitoring systems for beef drying. [ABSTRACT FROM AUTHOR]

To confirm the usefulness of noninvasive measurements of skin carotenoids to indicate vegetable intake and to elucidate relationships between skin carotenoid levels and biomarkers of circulatory diseases and metabolic syndrome, we conducted a cross-sectional study on a resident-based health checkup (n = 811; 58% women; 49.5 ± 15.1 years). Skin and serum carotenoid levels were measured via reflectance spectroscopy and high-performance liquid chromatography, respectively. Vegetable intake was estimated using a dietary questionnaire. Levels of 9 biomarkers (body mass index [BMI], brachial-ankle pulse wave velocity [baPWV], systolic and diastolic blood pressure [SBP and DBP], homeostasis model assessment as an index of insulin resistance [HOMA-IR], blood insulin, fasting blood glucose [FBG], triglycerides [TGs], and high-density lipoprotein cholesterol [HDL-C]) were determined. Skin carotenoid levels were significantly positively correlated with serum total carotenoids and vegetable intake (r = 0.678 and 0.210, respectively). In women, higher skin carotenoid levels were significantly associated with lower BMI, SBP, DBP, HOMA-IR, blood insulin, and TGs levels and higher HDL-C levels. In men, it was also significantly correlated with BMI and blood insulin levels. In conclusion, dermal carotenoid level may indicate vegetable intake, and the higher level of dermal carotenoids are associated with a lower risk of circulatory diseases and metabolic syndrome. [ABSTRACT FROM AUTHOR]

Fiber Bragg grating (FBG) sensors fabricated in silica optical fiber (Silica-FBG) have been used to measure the strain of human arteries as pulse wave signals. A variety of vital signs including blood pressure can be derived from these signals. However, silica optical fiber presents a safety risk because it is easily fractured. In this research, an FBG sensor fabricated in plastic optical fiber (POF-FBG) was employed to resolve this problem. Pulse wave signals were measured by POF-FBG and silica-FBG sensors for four subjects. After signal processing, a calibration curve was constructed by partial least squares regression, then blood pressure was calculated from the calibration curve. As a result, the POF-FBG sensor could measure the pulse wave signals with an signal to noise (SN) ratio at least eight times higher than the silica-FBG sensor. Further, the measured signals were substantially similar to those of an acceleration plethysmograph (APG). Blood pressure is measured with low error, but the POF-FBG APG correlation is distributed from 0.54 to 0.72, which is not as high as desired. Based on these results, pulse wave signals should be measured under a wide range of reference blood pressures to confirm the reliability of blood pressure measurement uses POF-FBG sensors. [ABSTRACT FROM AUTHOR]

There is a lack of quantitative and non-invasive clinical biomechanical assessment tools for diabetic foot ulcers. Our previous study reported that the indentation stiffness measured by an optical coherence tomography-based air-jet indentation system in a non-contact and non-invasive manner may reflect the tensile properties of diabetic wounds. As the tensile properties are known to be contributed by type I collagen, this study was aimed to establish the correlations between the indentation stiffness, and type I collagen abundance and organisation, in order to further justify and characterise the in vivo indentation stiffness measurement in diabetic wounds. In a male streptozotocin-induced diabetic rat model, indentation stiffness, and type I collagen abundance and organisation of excisional wounds were quantified and examined using the optical coherence tomography-based air-jet indentation system and picrosirius red polarised light microscopy, respectively, on post-wounding days 3, 5, 7, 10, 14, and 21. The results showed significant negative correlations between indentation stiffness at the wound centre, and the collagen abundance and organisation. The correlations between the indentation stiffness, as well as collagen abundance and organisation of diabetic wounds suggest that the optical coherence tomography-based air-jet indentation system can potentially be used to quantitatively and non-invasively monitor diabetic wound healing in clinical settings, clinical research or preclinical research., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Choi, Cheung, Ng, Zheng, Jan and Cheing.)

This review presents an overview of previously reported non-invasive intra-abdominal pressure (IAP) measurement techniques. Each section covers the basic physical principles and methodology of the various measurement techniques, the experimental results, and the advantages and disadvantages of each method. The most promising non-invasive methods for IAP measurement are microwave reflectometry and ultrasound assessment, in combination with an applied external force.

A 49-year-old man was diagnosed with acute cardiac insufficiency based on evidence of congestive heart failure. The non-invasive measurement of the cardiac output using an AESCULON ® mini showed low cardiac output (CO, 3.9 L/min). We administered an intravenous diuretic for cardiac edema and dobutamine drip for low cardiac output. Soon after starting dobutamine at 3.2 γ (microg/kg/min), the CO improved to 6.8 L/min. Combination therapy of diuretic and dobutamine resolved the heart failure. CO measurement by an AESCULON ® mini was safe, cost-effective, and convenient. Data output correlates with the CO by Swan-Ganz catheterization. The non-invasive measurement of the CO permitted a smooth recovery without recurrence in this patient.

Purpose: Close monitoring of patients at risk to develop an acute compartment syndrome (ACS) is well known to be essential. There is a relevant risk that clinical assessment alone is not reliable enough. Reliable assessment of the elasticity of the muscle compartment might represent a helpful tool to assess the pressure in this enclosed space. Therefore, the purpose of this study was to determine the feasibility of muscle elasticity measurements by a non-invasive device., Methods: In a prospective study, patients with elevated intra-compartmental pressure (ICP) were included. An ultrasound-based measurement approach was used to determine the relative elasticity (RE) of both, the affected and unaffected limb. A pressure transducing ultrasonic probe head was combined with the probe to obtain cross section views of the anterior tibial compartment and to detect the observer´s amount of pressure applied on the limb surface. The compartment depth without compression (P 0 ) corresponds to 100%. The difference to the compartment depth with a probe pressure of 80mmHg (P 80 ) on the limb (delta) related to P 0 resulted in a value of relative elasticity (%). These values were compared with the invasive needle measurement (mmHg) regarding their intra-individual difference and correlation of the compartmental pressure., Results: In six trauma patients the relative elasticity in their paired limbs showed a significant difference. The RE in the healthy compartments revealed a level of 17.95% (SD+/-5,4), whereas the RE of the affected limbs significantly decreased to a mean of 5,14% (SD+/-2,1) (p < 0,0001). The average values of the repetitively measured RE and the ICP showed a high level of correlation (spearman correlation coefficient: roh = 0,929). The RE less than 10,5% of the anterior tibial compartment had a sensitivity of 95,8% and a specificity of 87,5% to an appropriate diagnosis of ACS., Discussion: The presented study appears to represent a promising approach to reliably assess the pressure in a muscle compartment. In this first clinical study, our measurement method represents a low cost, easy and secure approach that has the potential to substitute invasive measurement. Further investigations and development in lager cohorts are required to improve its practicality and to confirm the reliability., Competing Interests: Declaration of Competing Interest The authors exclude any conflict of interest according the requirements of publishing standards as stated in the ICMJE recommendations., (Copyright © 2019. Published by Elsevier Ltd.)

A method is described to determine viable populations of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The method employs aptamer-magnetic separation combined with resistivity based detection. The bacteria were separated by means of aptamer-functionalized magnetic beads. They were then quantified by measuring their growth kinetics through time-dependent conductivity changes of culture media. The time-course of growth was logged by real-time and contactless measurements that yielded starting concentrations from the duration of lag intervals prior to the log phase of growth. In pure water samples, the linear ranges for measuring E. coli and S. aureus cells are 2.5 × 10 3 -2.5 × 10 8  CFU·mL -1 and 4.1 × 10 3 -4.1 × 10 8  CFU·mL -1 , respectively. In spiked tap water samples, the lower limits of detection are 2.3 × 10 4  CFU·mL -1 and 4.0 × 10 3  CFU·mL -1 for E. coli and S. aureus, with recoveries of 87.0-108.7% and 92.5-105.0%, respectively. The relative standard deviation of these measurements (10.0%) is below that of plate counting method (13.9%). The presence of micro/nanoparticles such as magnetic beads or selenium nanoparticles in the culture media does not interfere, unlike in case of automatted optical density monitoring. The E. coli and S. aureus cells captured on the aptamer-functionalized magnetic beads can be directly tested for their susceptibility to antibiotics. The process of magnetic separation and determination of load burden requires neither bulky, sophisticated equipment nor expensive reagents. Graphical abstractAptamer-functionalized magnetic beads are used to selectively capture and separate E. coli and S. aureus cells in aqueous samples. They are directly transferred to a multichannel conductometric sensor for the quantification of viable bacteria via automated monitoring of their growth kinetics.

Purpose: Latent autoimmune diabetes in adults (LADA) is a slowly progressing form of immune-mediated diabetes that combines phenotypical features of both type 2 diabetes mellitus (T2DM) and type 1 diabetes mellitus (T1DM), meaning that accurate and early diagnosis of this subtype of diabetes is critical for optimal long-term management. Urinary C-peptide creatinine ratio (UCPCR) represents a non-invasive and practical method for assessing endogenous insulin production to facilitate diabetes classification. However, no study to date has reported the use of UCPCR in identifying LADA., Patients and Methods: A total of 574 subjects were included in our study (42 LADA, 61 T1DM, 471 T2DM). All participants were evaluated for UCPCR and underwent clinical and laboratory evaluations. UCPCR was compared among different subtypes of diabetes using multinomial regression analysis, and a receiver operating characteristic (ROC) curve was used to identify its performance in diagnosing LADA., Results: UCPCR was lower in LADA (0.4±0.6 nmol/mmol) compared with T2DM (1.2±0.9 nmol/mmol), but higher than in T1DM (0.2±0.3 nmol/mmol) (p<0.05). The association between UCPCR and LADA remained significant after adjusting for gender, age, age at diagnosis, body mass index, high-density lipoprotein cholesterol, and triglyceride (OR, 95% confidence interval (CI), 0.29 (0.09, 0.95)). The ROC curve revealed an area under the curve of 0.835 (95% CI (0.742-0.928), p<0.001). The cut-off point for UCPCR ≤ 0.46 nmol/mmol was 82.1% for sensitivity and 76.7% for specificity in the diagnosis of LADA., Conclusion: UCPCR may represent a non-invasive, simple, and practical measurement of insulin secretion for early discrimination of LADA in routine clinical practice., Competing Interests: The authors report no conflicts of interest in this work., (© 2019 Liu et al.)

Arterial pulse wave has been considered as a vital sign in assessment of cardiovascular diseases. Noninvasive pulse sensor with compact structure, immunity to electro‐magnetic interference and high sensitivity is the research focus in recent years. While, optical fiber biosensor is a competitive option to meet these needs. Here, a diaphragm‐based optical fiber pulse sensor was proposed to achieve high‐precision radial pulse wave monitoring. A wearable device was developed, composed of a sports wristband and an aluminum diaphragm‐based optical fiber sensor tip of only 1 cm in diameter, which was highly sensitive to the weak acoustic signal. In particular, coherent phase detection was adopted to improve detection signal‐to‐noise ratio, so as to recover the high‐fidelity pulse waveforms. A clinical experiment was carried out to detect and morphological analyze the pulse waveforms of four subjects, the results of which preliminarily demonstrated the feasibility of pulse diagnosis method. The proposed pulse fiber sensor provides a comfortable way for pulse diagnosis, which is promising in early cardiovascular diseases indicating. [ABSTRACT FROM AUTHOR]

This paper reviews non-invasive blood glucose measurements via dielectric spectroscopy at microwave frequencies presented in the literature. The intent is to clarify the key challenges that must be overcome if this approach is to work, to suggest some possible ways towards addressing these challenges and to contribute towards prevention of unnecessary 'reinvention of the wheel'. [ABSTRACT FROM AUTHOR]