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251. Angiotensin receptor blocker losartan inhibits tumor growth of colorectal cancer

Author

Hashemzehi, Milad, Rahmani, Farzad, Khoshakhlagh, Mahdieh, Avan, Amir, Asgharzadeh, Fereshteh, Barneh, Farnaz, Moradi-Marjaneh, Reyhaneh, Soleimani, Atena, Fiuji, Hamid, Ferns, Gordon A., Ryzhikov, Mikhail, Jafari, Mohieddin, Khazaei, Majid, and Hassanian, Seyed Mahdi

Subjects
0303 health sciences, 03 medical and health sciences, 030311 toxicology, Original Article, colorectal cancer, renin-angiotensin system, Losartan
Abstract

The renin-angiotensin system (RAS) is up-regulated in patients with colorectal cancer (CRC) and is reported to be associated with poor prognosis and chemo-resistance. Here we explored the therapeutic potential of targeting RAS in CRC using Losartan, an angiotensin receptor blocker. An integrative-systems biology approach was used to explore a proteome-level dataset of a gene signature that is modulated by Losartan. The anti-proliferative activity of Losartan was evaluated using 2- and 3-dimensional cell culture models. A xenograft model of colon cancer was used to investigate tumor growth with Losartan alone and in combination with 5-FU followed by histological staining (Hematoxylin & Eosin and Masson trichrome staining), biochemical analyses, gene expression analyses by RT-PCR, western blot/IHC, or MMP Gelatin Zymography studies. Effects on cell cycle and cell death were assessed by flow cytometry. Losartan inhibited cell growth and suppressed cell cycle progression, causing an increase in CRC cells in the G1 phase. Losartan significantly reduced tumor growth and enhanced tumor cell necrosis. An impact on the inflammatory response, including up-regulation of pro-inflammatory cytokines and chemokines in CRC cells are potential mechanisms that could partially explain Losartan’s anti-proliferative effects. Moreover, metastasis and angiogenesis were reduced in Losartan-treated mice as observed by inhibited matrix metalloproteinase-2 and -9 activities and decreased tumor vasculature. These data demonstrate the therapeutic potential of combining chemotherapeutic regimens with Losartan to synergistically enhance its activity and target the renin-angiotensin system as a new approach in colorectal cancer treatment., EXCLI Journal; 20:Doc506; ISSN 1611-2156

Published
2021
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252. The beneficial effect of combination therapy with sulfasalazine and valsartan in the treatment of ulcerative colitis

Author

Asgharzadeh, Fereshteh, Yaghoubi, Atieh, Nazari, Seyedeh Elnaz, Hashemzadeh, Alireza, Hasanian, Seyed Mahdi, Avan, Amir, Javandoost, Ali, Ferns, Gordon A, Soleimanpour, Saman, and Khazaei, Majid

Subjects
angiotensin II receptor blocker, 0303 health sciences, 03 medical and health sciences, colitis, inflammation, 030311 toxicology, Original Article, digestive system diseases, valsartan, combination therapy
Abstract

Inflammatory bowel disease (IBD) is defined by the chronic inflammation of the digestive tract. Ulcerative colitis is one of the most prevalent chronic IBDs. The increase in the mucosal expression of angiotensin II (AT-II) in colitis suggests a possible role of AT-II in colitis-associated inflammation. Here, we examined the potential therapeutic effects of combination therapy regarding valsartan (Val), as an AT-II receptor blocker, with sulfasalazine (SSZ) in a murine colitis model. DSS induced colitis was initiated by the administration of dextran sodium sulfate (DSS) in male C57BL/6 mice for 1 week. Val (160 mg/kg/day, gavage) was given on the third day and continued for seven days. SSZ (100 mg/kg/day) was used as reference drug and also used in combination in one group (Val; 160 mg/kg/day and/or SSZ; 100 mg/kg/day). Colonic mucosal inflammation was evaluated clinically, biochemically, and histologically. The disease activity index in DSS-treated mice, including weight loss, stool consistency, and rectal bleeding, were significantly lower in the group of mice receiving the combination of valsartan and sulfasalazine compared to the DSS-treated group. Valsartan and sulfasalazine treatment was associated with a lower reduction in colon length, diminished colon weight, and high sensitivity C-reactive protein level in mice with DSS-induced colitis. Valsartan and sulfasalazine also reduced markers of oxidative stress after DSS administration. Our findings demonstrate the anti-inflammatory and anti-fibrotic activities of a combination therapy with sulfasalazine and valsartan in experimentally induced colitis, indicating its value as a potential therapeutic option for the treatment of colitis., EXCLI Journal; 20:Doc236; ISSN 1611-2156

Published
2021
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254. Serum HDL cholesterol uptake capacity in subjects from the MASHAD cohort study: Its value in determining the risk of cardiovascular endpoints

Author

Aghasizadeh, Malihe, primary, Samadi, Sara, additional, Sahebkar, Amirhossein, additional, Miri‐Moghaddam, Ebrahim, additional, Esmaily, Habibollah, additional, Souktanloo, Mohamad, additional, Avan, Amir, additional, Mansoori, Amin, additional, Ferns, Gordon A., additional, Kazemi, Tooba, additional, and Ghayour‐Mobarhan, Majid, additional

Published
2021
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256. Association of a Genetic Variant in the Cyclin-Dependent Kinase Inhibitor 2B with Risk of Pancreatic Cancer.

Author

Sardarzadeh, Newsha, Khojasteh-Leylakoohi, Fatemeh, Damavandi, Sedigheh, Khalili-Tanha, Ghazaleh, Dashtiahangar, Mohammad, Khalili-Tanha, Nima, Avan, Amir, Amoueian, Sakineh, Hassanian, Seyed Mahdi, Esmaily, Habibollah, Khazaei, Majid, Ferns, Gordon, Khooei, Alireza, and Aliakbarian, Mohsen

Subjects
CYCLIN-dependent kinase inhibitors, GENETIC variation, PANCREATIC cancer, DISEASE risk factors, GENETIC models
Abstract

Background: Pancreatic cancer (PC) is among the most aggressive tumors with a poor prognosis, indicating the need for the identification of a novel prognostic biomarker for risk stratifications. Recent genome-wide association studies have demonstrated common genetic variants in a region on chromosome 9p21 associated with an increased risk of different malignancies. Methods: In the present study, we explore the possible relationship between genetic variant, rs10811661, and gene expression of CDKN2B in 75 pancreatic cancer patients, and 188 healthy individuals. DNAs were extracted and genotyping and gene expression were performed by TaqMan real-time PCR and RT-PCR, respectively. Logistic regression was used to assess the association between risk and genotypes, while the significant prognostic variables in the univariate analysis were included in multivariate analyses. Results: The patients with PDAC had a higher frequency of a TT genotype for rs10811661 than the control group. Also, PDAC patients with dominant genetic model, (TT + TC), was associated with increased risk of developing PDAC (OR= 14.71, 95% CI [1.96-110.35], p= 0.009). Moreover, patients with CC genotype had a higher expression of CDKN2B, in comparison with TT genotype. Conclusions: Our findings demonstrated that CDKN2A/B was associated with the risk of developing PDAC, supporting further investigations in the larger and multicenter setting to validate the potential value of this gene as an emerging marker for PDAC. [ABSTRACT FROM AUTHOR]

Published
2022

257. Novel formulated form of turmeric oleoresin inhibits cell growth and migratory behaviors of breast cancer cells.

Author

Bahmani, Zahede, Ghasemi, Faezeh, Pourali, Ghazaleh, Mehrabadi, Shima, Hassanian, Seyed Mahdi, ShahidSales, Soodabeh, Moghaddam, Masoud Saleh, Ebrahimi, Safieh, Sahebkar, Amirhossein, and Avan, Amir

Subjects
BREAST cancer, OLEORESINS, TURMERIC, CELL growth, CANCER cell migration, ANTINEOPLASTIC agents
Abstract

Background and Objective: Curcumin is a polyphenolic compound derived from Curcumin longa L. There is growing body of data showing the antitumor effect of curcumin in different cancers; however, its efficacy is limited by its low absorption rate. Here, we investigated the antitumor activity of turmeric oleoresin alone or in combination with paclitaxel in MCF-7 cells in monolayer cell cultures and spheroids models. Methods: The antiproliferative activities of 3 different form, curcumin, phospholipidated curcumin, and turmeric oleoresin were assessed by MTT assay. The migratory behaviors of the cells were determined by migration assay before and after treatment with curcumin. The expression levels of CyclinD1, P65, Nf-kB, and E-cadherin were studied. Findings: Curcumin suppressed cell growth in MCF-7 cells via modulation of CyclinD1 and NF-KB, which was more pronounced with turmeric oleoresin. Curcumin was able to reduce the invasiveness of MCF-7, compared to control cells through perturbation of E-cadherin. Conclusion: We demonstrated the antitumor activity of curcumin and curcumin oleoresin in breast cancer cells, supporting further investigations on the therapeutic potential of this novel anticancer agent in in vivo models. [ABSTRACT FROM AUTHOR]

Published
2022
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259. Programmed cell death 1 as prognostic marker and therapeutic target in upper gastrointestinal cancers

Author

Khoshghamat, Negar, primary, Jafari, Niloufar, additional, Moetamani-Ahmadi, Mehrdad, additional, Khalili-Tanha, Ghazaleh, additional, Khajavi rad, Mohammad-Hossein, additional, Sahebdel, Saeed, additional, Khalili-Tanha, Nima, additional, Soleimanpour, Saman, additional, Khazaei, Majid, additional, Hassanian, Seyed Mahdi, additional, Ferns, Gordon A., additional, and Avan, Amir, additional

Published
2021
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261. Association of Interleukin-10 –592 C > A gene polymorphism with coronary artery disease: A case-control study and meta-analysis

Author

Ghalandari, Marzieh, primary, Jamialahmadi, Khadijeh, additional, Nik, Maryam Mardan, additional, Pirhoushiaran, Maryam, additional, Mirhafez, Seyed Reza, additional, Rooki, Hassan, additional, Avan, Amir, additional, Ghazizadeh, Hamideh, additional, Moohebati, Mohsen, additional, Nohtani, Mahdi, additional, Zaimkohan, Hooshang, additional, Ferns, Gordon A., additional, Pasdar, Alireza, additional, and Ghayour-Mobarhan, Majid, additional

Published
2021
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262. Inhibition of transforming growth factor-beta by Tranilast reduces tumor growth and ameliorates fibrosis in colorectal cancer

Author

Hashemzehi, Milad, Yavari, Negar, Rahmani, Farzad, Asgharzadeh, Fereshteh, Soleimani, Atena, Shakour, Neda, Avan, Amir, Hadizadeh, Farzin, Fakhraie, Maryam, Moradi Marjaneh, Reyhaneh, Ferns, Gordon A., Reisi, Parham, Ryzhikov, Mikhail, Khazaei, Majid, and Hassanian, Seyed Mahdi

Subjects
0303 health sciences, 03 medical and health sciences, angiogenesis, Tranilast, colon cancer, fibrosis, 030311 toxicology, Original Article, TGF pathway
Abstract

Transforming Growth Factor-beta (TGF-β) is dysregulated in colorectal cancer and there is growing evidence that it is associated with a poor prognosis and chemo-resistance in several malignances, including CRC. In this study we have explored the therapeutic potential of targeting TGF-β using Tranilast in colon cancer. The anti-proliferative activity of Tranilast was evaluated in 2- and 3-dimensional cells. We used a xenograft model of colon cancer to investigate the activity of Tranilast alone or in combination with 5-FU on tumor growth using histological staining and biochemical studies, as well as gene expression analyses using RT-PCR and Western blotting. Tranilast alone or in combination with 5-FU inhibited tumor growth and was associated with a reduction of TGF-β expression and CD31 positive endothelial cells. Histological evaluation showed that Tranilast increased tumor necrosis and reduced tumor density and angiogenesis. Tranilast increased MDA and ROS production. It was also found that Tranilast reduced total thiol concentration and reduced SOD and catalase activity. Tranilast plus 5-FU was also found to attenuate collagen deposition, reducing tumor fibrosis in tumor xenografts. Our results show that Tranilast, a TGF inhibitor, in combination with 5-FU reduces tumor growth by inhibiting fibrosis and inducting ROS, thus supporting this therapeutic approach in CRC treatment., EXCLI Journal; 20:Doc601; ISSN 1611-2156

Published
2020

263. The association of a genetic variant in CDKN2A/B gene and the risk of colorectal cancer

Author

Rahmani, Farzad, Avan, Amir, Amerizadeh, Forouzan, Ferns, Gordon A., Talebian, Sahar, and Shahidsales, Soodabeh

Subjects
0303 health sciences, 03 medical and health sciences, 030311 toxicology, Original Article, CDKN2A/B, Polymorphism, Colorectal cancer
Abstract

Colorectal cancer is among the most aggressive tumors, and its development involves an interplay between various genetic and environmental familial risk factors. Several genetic polymorphisms have been reported to be associated with colorectal cancer in recent studies. In this current study, we aimed to evaluate the possible relationship between a CDKN2A/B, single nucleotide polymorphisms (SNP) (rs10811661), with the risk of colorectal cancer. A total of 541 individuals with, or without cancer were recruited. DNA was extracted, and genotyped using a Taq-Man based real‐time PCR method. The rs10811661 SNP was associated with an increased risk of colorectal cancer (additive model: OR=3.46, CI= 1.79-6.69, p, EXCLI Journal; 19:Doc1316; ISSN 1611-2156

Published
2020
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266. SF3B1 modulators affect key genes in metastasis and drug influx: a new approach to fight pancreatic cancer chemoresistance

Author

Randazzo, Ornella, primary, Cascioferro, Stella M., additional, Pecoraro, Camilla, additional, Iddouch, Widad Ait, additional, Avan, Amir, additional, Parrino, Barbara, additional, Carbone, Daniela, additional, Perricone, Ugo, additional, Peters, Godefridus J., additional, Diana, Patrizia, additional, and Giovannetti, Elisa, additional

Published
2021
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267. Interaction between a genetic variant in vascular endothelial growth factor with dietary intakes in association with the main factors of metabolic syndrome

Author

Ghazizadeh, Hamideh, primary, Esmaily, Habibollah, additional, Sharifan, Payam, additional, Parizadeh, Seyed Mohammad Reza, additional, Ferns, Gordon A., additional, Rastgar-Moghadam, Azam, additional, Khedmatgozar, Hamed, additional, Ghayour-Mobarhan, Majid, additional, and Avan, Amir, additional

Published
2020
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275. Inhibition of Angiotensin II Type I Pathway Reduced Tumor Growth and Ameliorates Fibrosis/inflammation Associated with Colorectal Cancer

Author

Asgharzadeh, Fereshteh, primary, Mostafapour, Asma, additional, Amerizadeh, Forouzan, additional, Avan, Amir, additional, Rahmani, Farzad, additional, Sabbaghzadeh, Reihaneh, additional, Hassanian, Seyed Mahdi, additional, Fakhraei, Maryam, additional, Farshbaf, Alieh, additional, Ferns, Gordon A, additional, Giovannetti, Elisa, additional, Cho, William C., additional, and Khazaei, Majid, additional

Published
2020
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277. Association between genetic variants at 9p21 locus with risk of breast cancer: A systematic review and meta-analysis

Author

Abdeahad, Hossein, primary, Bahrami, Afsane, additional, Saeedi, Nikoo, additional, Shabani, Mohammad, additional, Pezeshki, Milad, additional, Khazaei, Majid, additional, Shafiee, Mojtaba, additional, Ghorbani, Elnaz, additional, Ferns, Gordon A, additional, Soleimanpour, Saman, additional, Rahmani, Farzad, additional, Soleimani, Atena, additional, Fiuji, Hamid, additional, Ryzhikov, Mikhail, additional, Avan, Amir, additional, and Mahdi Hassanian, Seyed, additional

Published
2020
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281. Association of a genetic variant in the AKT gene locus and cardiovascular risk factors

Author

Kermanshahi, Farnoush, primary, Ghazizadeh, Hamideh, additional, Hussein, Nasih Abdulla, additional, Amerizadeh, Forouzan, additional, Samadi, Sara, additional, Tayefi, Maryam, additional, Kamel Khodabandeh, Atiyeh, additional, Moohebati, Mohsen, additional, Ebrahimi, Mahmoud, additional, Esmaily, Habibollah, additional, Sahebi, Reza, additional, Abdulkarimi, Rahim, additional, Mousavi, Seyed Ali Reza, additional, Ferns, Gordon A, additional, Avan, Amir, additional, and Ghayour-Mobarhan, Majid, additional

Published
2020
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283. Bacteria and cancer: Different sides of the same coin

Author

Laliani, Ghazaleh, primary, Ghasemian Sorboni, Shokufeh, additional, Lari, Roya, additional, Yaghoubi, Atieh, additional, Soleimanpour, Saman, additional, Khazaei, Majid, additional, Hasanian, Seyed Mahdi, additional, and Avan, Amir, additional

Published
2020
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284. Intraperitoneal Administration of Telmisartan Prevents Postsurgical Adhesion Band Formation

Author

Arjmand, Mohammad-Hassan, primary, Zahedi-Avval, Farnaz, additional, Barneh, Farnaz, additional, Mousavi, Seyed Hadi, additional, Asgharzadeh, Fereshteh, additional, Hashemzehi, Milad, additional, Soleimani, Atena, additional, Avan, Amir, additional, Fakhraie, Maryam, additional, Nasiri, Seyedeh Najibeh, additional, Mehraban, Saeedeh, additional, Ferns, Gordon A., additional, Ryzhikov, Mikhail, additional, Jafari, Mohieddin, additional, Khazaei, Majid, additional, and Hassanian, Seyed Mahdi, additional

Published
2020
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285. Circulating and tissue microRNAs as a potential diagnostic biomarker in patients with thrombotic events

Author

Jafarzadeh‐Esfehani, Reza, primary, Mostafa Parizadeh, Seyed, additional, Sabeti Aghabozorgi, Amirsaeed, additional, Yavari, Negar, additional, Sadr‐Nabavi, Ariane, additional, Alireza Parizadeh, Seyed, additional, Ghandehari, Maryam, additional, Javanbakht, Afsane, additional, Rezaei‐Kalat, Afsaneh, additional, Mahdi Hassanian, Seyed, additional, Vojdanparast, Mohammad, additional, Ferns, Gordon A., additional, Khazaei, Majid, additional, and Avan, Amir, additional

Published
2020
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294. Association between serum cell adhesion molecules with hs-CRP, uric acid and VEGF genetic polymorphisms in subjects with metabolic syndrome

Author

Ghazizadeh, Hamideh, primary, Rezaei, Majid, additional, Avan, Amir, additional, Fazilati, Mohammad, additional, Pasdar, Alireza, additional, Tavallaie, Shima, additional, Kazemi, Elham, additional, Seyedi, Seyed Mohammad Reza, additional, Ferns, Gordon A., additional, Azimi-Nezhad, Mohsen, additional, and Ghayour-Mobarhan, Majid, additional

Published
2019
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296. Vitamin D in inflammatory bowel disease: From biology to clinical implications

Author

Parizadeh, Seyed Mostafa, primary, Jafarzadeh-Esfehani, Reza, additional, Hassanian, Seyed Mahdi, additional, Mottaghi-Moghaddam, Ali, additional, Ghazaghi, Anahita, additional, Ghandehari, Maryam, additional, Alizade-Noghani, Mohadese, additional, Khazaei, Majid, additional, Ghayour-Mobarhan, Majid, additional, Ferns, Gordon A., additional, Parizadeh, Seyed Mohammad Reza, additional, and Avan, Amir, additional

Published
2019
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297. A Genetic Variant in Proline and Serine Rich Coiled-Coil 1 Gene Is Associated with the Risk of Cardiovascular Disease.

Author

Khorrami, Mohammad Sadegh, Sadabadi, Fatemeh, Pasdar, Alireza, Safarian-Bana, Hamide, Amerizadeh, Forouzan, Esmaeily, Habibollah, Moohebati, Mohsen, Heidari-Bakavoli, Alireza, Ferns, Gordon, Ghayour-Mobarhan, Majid, and Avan, Amir

Subjects
GENETIC variation, LDL cholesterol, PROLINE, CARDIOVASCULAR diseases, CARDIOVASCULAR diseases risk factors
Abstract

Background: Cardiovascular disease is one of the most common causes of morbidity and mortality worldwide. The Proline and Serine Rich Coiled-Coil 1 gene in 1p13.3 locus has been reported to be associated with low density lipoprotein cholesterol (LDL-C) and coronary artery disease (CAD). The objective of this study was to investigate the association between the rs599839 polymorphism of the Proline and Serine Rich Coiled-Coil 1 (PSRC1) gene with CVD outcomes in a population sample recruited as part of the Mashhad-Stroke and Heart-Atherosclerotic-Disorders (MASHAD) cohort. Methods: Five hundred and nine individuals who had an average follow-up period of 10 years were enrolled as part of the MASHAD cohort. DNA was extracted and genotyped using the TaqMan-real-time-PCR based method. Results: The study found individuals with GA/GG genotypes were at a higher risk of CVDs (OR= 4.7; 95% CI, 2.5-8.7; p< 0.001) in comparison to those with AA genotype; however, the result was not significant for GG genotype data. Conclusions: The results suggest that the GA/GG genotypes of the PSRC1gene locus were at increased risk of CVD in a representative population-based cohort, demonstrating further functional analysis to discover the value of emerging marker as a risk stratification biomarker to recognize high risk cases. [ABSTRACT FROM AUTHOR]

Published
2022
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298. Interaction between the genetic variant of rs696217‐ghrelin and food intake and obesity and dyslipidemia.

Author

Yadegari, Mehran, Zare‐Feyzabadi, Reza, Zakariaeiseraji, Mohanna, Sahebi, Reza, Shabani, Niloofar, Khedmatgozar, Hamed, Ferns, Gordon A., Ghazizadeh, Hamideh, Mohammadi‐Bajgiran, Maryam, Jalalian, Melika, Zoghi, Mohadese, Darban, Reza Assaran, Mohammadian‐Ghosooni, Mahdi, Esmaily, Habibollah, Avan, Amir, and Ghayour‐Mobarhan, Majid

Subjects
GENETIC variation, FOOD consumption, OBESITY, DISEASE risk factors, DYSLIPIDEMIA, NUTRITIONAL genomics
Abstract

In this study, we aimed to investigate the relationship between the genetic variant of rs696217‐ghrelin and fasted lipid profile, indices of obesity, and environmental parameters. Amplification refractory mutation system‐polymerase chain reaction (ARMs‐PCR) was used for genotyping 1118 individuals recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) cohort study. The interaction between the presence of the genetic variant of rs696217‐ghrelin and nutritional intake and other major determinants of obesity and lipid profile was examined in the MASHAD study population. Individuals with the TT genotype at the locus had the lowest prevalence of obesity compared to other genotypes among the individuals. No significant relationship was found between the two groups regarding the lipid profile and TT genotype. Furthermore, no significant association was found between dietary intake and the genetic variant of rs696217‐ghrelin in the population under study. Individuals with a TT or GT genotype appear to be at a higher risk of obesity, compared to those with a GG genotype. The results of the current study revealed a significant association between the genetic variant of rs696217‐ghrelin and obesity; however, this gene did not correlate with the risk factors of cardiovascular diseases and dyslipidemia in the Iranian population. [ABSTRACT FROM AUTHOR]

Published
2022
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299. Human T lymphotropic virus type 1 and risk of cardiovascular disease: High-density lipoprotein dysfunction versus serum HDL-C concentrations

Author

Samadi, Sara, Abolbashari, Samaneh, Meshkat, Zahra, Mohammadpour, Amir Hooshang, Kelesidis, Theodoros, Gholoobi, Aida, Mehramiz, Mehrane, Tabadkani, Mahla, Sadabadi, Fatemeh, Dalirfardouei, Razieh, Ferns, Gordon A, Ghayour-Mobarhan, Majid, and Avan, Amir

Subjects
Adult, Male, Biochemistry & Molecular Biology, HDL, Lipoproteins, HDL lipid peroxidation, high-density lipoprotein, Cardiovascular, Risk Factors, HDLox, Clinical Research, Humans, 2.1 Biological and endogenous factors, Aetiology, Triglycerides, HTLV1 infection, Human T-lymphotropic virus 1, Prevention, Middle Aged, Atherosclerosis, Cholesterol, Heart Disease, Infectious Diseases, Good Health and Well Being, Cardiovascular Diseases, Female, Biochemistry and Cell Biology, Infection, viral infectious disease, Software, Biomarkers
Abstract

High-density lipoprotein (HDL) is thought to be protective against cardiovascular disease (CVD), and HDL dysfunction is considered to be a risk factor for CVD. It is unclear whether there is an association between Human T lymphotropic virus type 1 (HTLV1) infection and CVD risk. We have assessed HDL lipid peroxidation (HDLox) as a marker of HDL dysfunction and CVD risk in a subgroup of the MASHAD cohort study. One hundred and sixty two individuals including 50 subjects positive for HTLV1 infection and 112 individuals negative for HTLV1 infection were recruited. Anthropometric and biochemical parameters including serum hs-CRP, fasted lipid profile (HDL-C, LDL, triglycerides, and cholesterol), and fasting blood glucose were determined. Serum HDLox was also measured in the study participants. Multivariate analyses were used to evaluate the association between serum HDLox and HTLV1 infection. None of the traditional CVD risk factors were associated with HTLV1 infection, including serum HDL-C. However, serum HDLox was independently associated with the presence of HTLV1 infection. Logistic regression analysis showed that subjects who were positive for HTLV1 infection were also significantly more likely than uninfected individuals to have higher HDLox (odds ratio 9.35, 95%CI: 3.5-24.7; P < 0.001). HDLox was increased approximately 20% (P < 0.001) in infected subjects compared to the uninfected group. Serum HDLox is a marker of CVD risk factor and increased in individuals affected by HTLV1 infection compared to healthy subjects. © 2019 BioFactors, 45(3):374-380, 2019.

Published
2019

300. A genetic variant in CDKN2A/2B locus was associated with poor prognosis in patients with 1 esophageal squamous cell carcinoma

Author

Ghobadi, Niloofar, Mehramiz, Mehrane, ShahidSales, Soodabeh, Brojerdi, Arezou Rezaei, Anvari, Kazem, Khazaei, Majid, Rezayi, Majid, Khorrami, Mohammad Sadegh, Joudi-Mashhad, Mona, Ramshini, Hassan, Ahmadi-Simab, Saeideh, Moradi, Ali, Hassanian, Seyed Mahdi, Ghayour-Mobarhan, Majid, Boroushaki, Mohammad Taher, Ferns, Gordon A, and Avan, Amir

Subjects
neoplasms, digestive system diseases
Abstract

Esophageal squamous cell carcinoma (ESCC) is among the leading causes of cancer related death. Despite extensive efforts in identifying valid cancer prognostic biomarkers, only a very small number of markers have been identified. Several genetic variants in the 9p21 region have been identified that are associated with the risk of multiple cancers. Here, we explored the association of two genetic variants in the 9p21 region, CDKN2A/B, rs10811661 and rs1333049 for the first time in 273 subjects with, or without ESCC. We observed that patients with ESCC had a higher frequency of a TT genotype for rs10811661 than individuals in the control group, and this polymorphism was also associated with tumor size. Moreover, a CC genotype for the rs1333049 polymorphism was associated with a reduced OS of patients with ESCC. In particular, patients with a CC (rs1333049) genotype had a significantly shorter OS (CC genotype: 34.5±8.9 months vs. CG+GG: 47.7±5.9 months; p value= 0.03). We have also shown the association of a novel genetic variant in CDKN2B gene with clinical outcome of ESCC patients. Further investigations are warranted in a larger population to explore the value of emerging markers as a risk stratification marker in ESCC.\ud \ud Key word: Esophageal squamous cell carcinoma, risk marker, CDKN2A/B, polymorphism

Published
2019

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