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252. LBSAT141 Bone Health In Patients With Adrenal Disorders

Author

Dogra, Prerna, primary, Šambula, Lana, additional, Zhang, Catherine D, additional, Thangamuthu, Karthik, additional, Nathani, Rohit, additional, Kastelan, Darko, additional, Ambroziak, Urszula, additional, Genere, Natalia, additional, Delivanis, Danae, additional, and Bancos, Irina, additional

Published
2022
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253. Steroid and global metabolome in benign adrenal tumours with mild autonomous cortisol secretion: analysis by mass spectrometry and machine learning to understand metabolic risk

Author

Prete, Alessandro, primary, Abdi, Lida, additional, Canducci, Marco, additional, Taylor, Angela E., additional, Bancos, Irina, additional, Gilligan, Lorna C., additional, Jenkinson, Carl, additional, Albors-Zumel, Ariadna, additional, van, den Brandhof Elina, additional, Zhang, Yuanqing, additional, Chortis, Vasileios, additional, Tsagarakis, Stylianos, additional, Lang, Katharina, additional, Macech, Magdalena, additional, Delivanis, Danae A., additional, Pupovac, Ivana D., additional, Reimondo, Giuseppe, additional, Marina, Ljiljana V., additional, Deutschbein, Timo, additional, Balomenaki, Maria, additional, O'Reilly, Michael W., additional, Bednarczuk, Tomasz, additional, Zhang, Catherine D., additional, Dusek, Tina, additional, Diamantopoulos, Aristidis, additional, Asia, Miriam, additional, Kondracka, Agnieszka, additional, Li, Dingfeng, additional, Masjkur, Jimmy R., additional, Quinkler, Marcus, additional, Ueland, Grethe AE., additional, Conall, Dennedy M., additional, Beuschlein, Felix, additional, Tabarin, Antoine, additional, Fassnacht, Martin, additional, Ivovic, Miomira, additional, Terzolo, Massimo, additional, Kastelan, Darko, additional, Young, Jr William F., additional, Manolopoulos, Konstantinos M., additional, Ambroziak, Urszula, additional, Vassiliadi, Dimitra A., additional, Sitch, Alice J., additional, Tino, Peter, additional, Biehl, Michael, additional, Dunn, Warwick B., additional, and Arlt, Wiebke, additional

Published
2022
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255. American Association of Endocrine Surgeons Guidelines for Adrenalectomy

Author

Yip, Linwah, primary, Duh, Quan-Yang, additional, Wachtel, Heather, additional, Jimenez, Camilo, additional, Sturgeon, Cord, additional, Lee, Cortney, additional, Velázquez-Fernández, David, additional, Berber, Eren, additional, Hammer, Gary D., additional, Bancos, Irina, additional, Lee, James A., additional, Marko, Jamie, additional, Morris-Wiseman, Lilah F., additional, Hughes, Marybeth S., additional, Livhits, Masha J., additional, Han, Mi-Ah, additional, Smith, Philip W., additional, Wilhelm, Scott, additional, Asa, Sylvia L., additional, Fahey, Thomas J., additional, McKenzie, Travis J., additional, Strong, Vivian E., additional, and Perrier, Nancy D., additional

Published
2022
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259. The metabolic phenotype of patients with primary aldosteronism: impact of subtype and sex – a multicenter-study of 3566 Caucasian and Asian subjects

Author

Spyroglou, Ariadni, primary, Handgriff, Laura, additional, Müller, Lisa, additional, Schwarzlmüller, Paul, additional, Parasiliti-Caprino, Mirko, additional, Fuss, Carmina Teresa, additional, Remde, Hana, additional, Hirsch, Anna, additional, O’Toole, Samuel Matthew, additional, Thuzar, Moe, additional, Petramala, Luigi, additional, Letizia, Claudio, additional, Deflorenne, Elisa, additional, Amar, Laurence, additional, Vrckovnik, Rok, additional, Kocjan, Tomaz, additional, Zhang, Catherine D, additional, Li, Dingfeng, additional, Singh, Sumitabh, additional, Katabami, Takuyuki, additional, Yoneda, Takashi, additional, Murakami, Masanori, additional, Wada, Norio, additional, Inagaki, Nobuya, additional, Quinkler, Marcus, additional, Ghigo, Ezio, additional, Maccario, Mauro, additional, Stowasser, Michael, additional, Drake, William M, additional, Fassnacht, Martin, additional, Bancos, Irina, additional, Reincke, Martin, additional, Naruse, Mitsuhide, additional, and Beuschlein, Felix, additional

Published
2022
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260. Hemodynamics in Patients With Pheochromocytoma or Paraganglioma Undergoing Non-neuroendocrine Operations

Author

Valencia Morales, Diana J., primary, Laporta, Mariana L., additional, Zec, Simon, additional, Yu, Kai, additional, Bancos, Irina, additional, Martin, David P., additional, Martin McGrew, Yvette N., additional, Weingarten, Toby N., additional, Hanson, Andrew C., additional, Sun, Junzhi, additional, Schroeder, Darrell R., additional, and Sprung, Juraj, additional

Published
2022
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265. Determinants of muscle function and health-related quality of life in patients with endogenous hypercortisolism: a cross-sectional study.

Author

Dingfeng Li, Zhang, Catherine D., Saini, Jasmine, Singh, Sumitabh, Nathani, Rohit, Thangamuthu, Karthik, Suresh, Malavika, Atkinson, Elizabeth J., Achenbach, Sara J., Van Gompel, Jamie, Young, William F., and Bancos, Irina

Subjects
MUSCLE strength, QUALITY of life, CUSHING'S syndrome
Abstract

Objective: Prospective data on determinants of muscle strength impairment and quality of life in patients with various subtypes and severity of endogenous hypercortisolism are lacking. Design: Single-center cross-sectional study, 2019 to 2022. Methods: Patients with Cushing syndrome (CS) and mild autonomous cortisol secretion (MACS) were assessed with clinical and biochemical severity scores, muscle function (nondominant hand grip strength and sit-to-stand test), and quality of life (Short Form-36 [SF36] and CushingQoL). Referent subjects were recruited from the local population undergoing abdominal imaging for reasons other than suspected adrenal disorder. Results: Of 164 patients, 81 (49%) had MACS, 14 (9%) had adrenal CS, 60 (37%) had pituitary CS, and 9 (5%) had ectopic CS. Median age was 53 years (interquartile range: 42-63 years), and 126 (77%) were women. The SF36 mental component score was similarly low in patients with MACS vs CS, but physical component score was lower in CS when compared to MACS (mean of 34.0 vs 40.5, P = .001). Compared to MACS, patients with CS had lower scores on the standardized CushingQoL (mean of 47.1 vs 34.2, P < .001). Compared to referent subjects, patients with MACS demonstrated reduced muscle strength, similar to patients with CS (mean sit to stand Z-score of -0.47 vs -0.54, P = .822). Clinical severity (r = -0.22, P = .004) but not biochemical severity was associated with sit-to-stand test performance. Conclusions: Both patients with overt CS and MACS demonstrate reduced muscle strength and low quality of life. The clinical severity score utilized is associated with both physical and psychosocial components of CushingQoL and with the physical component of SF36. [ABSTRACT FROM AUTHOR]

Published
2023
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267. Presentation, Management, and Outcomes of Urinary Bladder Paraganglioma: Results From a Multicenter Study

Author

Yu, Kai, primary, Ebbehøj, Andreas Ladefoged, additional, Obeid, Hiba, additional, Vaidya, Anand, additional, Else, Tobias, additional, Wachtel, Heather, additional, Main, Ailsa Maria, additional, Søndergaard, Esben, additional, Lehmann Christensen, Louise, additional, Juhlin, Christofer, additional, Calissendorff, Jan, additional, Cohen, Debbie L, additional, Bennett, Bonita, additional, Andersen, Marianne Skovsager, additional, Larsson, Catharina, additional, Almeida, Madson Q, additional, Fishbein, Lauren, additional, Boorjian, Stephen A, additional, Young, William F, additional, and Bancos, Irina, additional

Published
2022
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268. Histopathology and Genetic Causes of Primary Aldosteronism in Young Adults

Author

Nanba, Kazutaka, primary, Baker, Jessica E, additional, Blinder, Amy R, additional, Bick, Nolan R, additional, Liu, Chia-Jen, additional, Lim, Jung Soo, additional, Wachtel, Heather, additional, Cohen, Debbie L, additional, Williams, Tracy Ann, additional, Reincke, Martin, additional, Lyden, Melanie L, additional, Bancos, Irina, additional, Young, William F, additional, Else, Tobias, additional, Giordano, Thomas J, additional, Udager, Aaron M, additional, and Rainey, William E, additional

Published
2022
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271. Corrigendum to ‘Multiple endocrine neoplasia type 1 in children and adolescents: Clinical features and treatment outcomes’ [Surgery 171 (2021) 77–87]

Author

Shariq, Omair A., primary, Lines, Kate E., additional, English, Katherine A., additional, Jafar-Mohammadi, Bahram, additional, Prentice, Philippa, additional, Casey, Ruth, additional, Challis, Benjamin G., additional, Selberherr, Andreas, additional, Boon, Hannah, additional, Cranston, Treena, additional, Ryan, Fiona J., additional, Mihai, Radu, additional, Healy, Ultan, additional, Kurzawinski, Tom, additional, Dattani, Mehul T., additional, Bancos, Irina, additional, Dy, Benzon M., additional, Lyden, Melanie L., additional, Young, William F., additional, McKenzie, Travis J., additional, Richards, Duncan, additional, and Thakker, Rajesh V., additional

Published
2022
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277. Urinary steroid metabolomics for adrenocortical cancer diagnosis. Comparison of gas chromatography mass spectrometry to liquid chromatography mass spectrometry

Author

Taylor, Angela, primary, Bancos, Irina, additional, Gilligan, Lorna, additional, van, Veen Rick, additional, Chortis, Vasileios, additional, Shaheen, Fozia, additional, Jenkinson, Carl, additional, O'Neil, Donna M, additional, Hughes, Beverly, additional, Hawley, James M, additional, Keevil, Brian, additional, Shackelton, Cedric H L, additional, Deeks, Jonathan, additional, Sitch, Alice J, additional, Biehl, Michael, additional, and Arlt, Wiebke, additional

Published
2022
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278. Classic and 11-oxygenated androgens in serum and saliva across adulthood and the menstrual cycle - a mass spectrometry-based cross-sectional study

Author

Kempegowda, Punith, primary, Schiffer, Lina, additional, Adaway, Jo, additional, Shaheen, Fozia, additional, Ebbehoj, Andreas, additional, Singh, Sumitabh, additional, Prete, Alessandro, additional, Hawley, James M, additional, Sitch, Alice J, additional, Keevil, Brian, additional, Bancos, Irina, additional, Taylor, Angela, additional, and Arlt, Wiebke, additional

Published
2022
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281. Corrigendum: Relacorilant, a Selective Glucocorticoid Receptor Modulator, Induces Clinical Improvements in Patients With Cushing Syndrome: Results From A Prospective, Open-Label Phase 2 Study

Author

Pivonello, Rosario, primary, Bancos, Irina, additional, Feelders, Richard A., additional, Kargi, Atil Y., additional, Kerr, Janice M., additional, Gordon, Murray B., additional, Mariash, Cary N., additional, Terzolo, Massimo, additional, Ellison, Noel, additional, and Moraitis, Andreas G., additional

Published
2022
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284. Supplementary Data: Presentation, Management, and Outcomes of Urinary Bladder Paraganglioma: Results from a Multi-center Study.docx

Author

Yu, Kai, Ebbehoj, Andreas, Obeid, Hiba, Vaidya, Anand, Else, Tobias, Wachtel, Heather, Main, Ailsa Maria, Søndergaard, Esben, Christensen, Louise Lehmann, Juhlin, C. Christofer, Calissendorff, Jan, Cohen, Debbie L, Bennett, Bonita, Andersen, Marianne Skovsager, Larsson, Catharina, Almeida, Madson Q, Fishbein, Lauren, Boorjian, Stephen A, Jr., William F. Young, and Bancos, Irina

Abstract

Supplementary data

Published
2022
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285. First randomized trial on adjuvant mitotane in adrenocortical carcinoma patients: The Adjuvo study.

Author

Berruti, Alfredo, primary, Fassnacht, Martin, additional, Libè, Rossella, additional, Lacroix, Andrè, additional, Kastelan, Darko, additional, Haak, Harm, additional, Arlt, Weibke, additional, Decoudier, Bénédict, additional, Lasolle, Hélène, additional, Bancos, Irina, additional, Quinkler, Markus, additional, Barisson Villares Fragoso, Maria Candida, additional, Canu, Letizia, additional, Puglisi, Soraya, additional, Bourdeau, Isabelle, additional, Baudin, Eric, additional, Berchialla, Paola, additional, Beuschlein, Felix, additional, Bertherat, Jerome, additional, and Terzolo, Massimo, additional

Published
2022
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290. Cardiometabolic Outcomes and Mortality in Patients with Adrenal Adenomas in a Population-based Setting:A Population-Based Cohort Study

Author

Zhang, Catherine D, Li, Dingfeng, Kaur, Ravinder Jeet, Ebbehoj, Andreas, Singh, Sumitabh, Atkinson, Elizabeth J, Achenbach, Sara J, Young, William F, Arlt, Wiebke, Rocca, Walter A, and Bancos, Irina

Subjects
Male, Adult, Epidemiology, Adrenal Gland Neoplasms/physiopathology, prevalence, Adrenal Gland Neoplasms, adrenal incidentaloma, Minnesota/epidemiology, Metabolic Diseases/epidemiology, cardiovascular events, adrenal mass, Young Adult, Humans, Mortality, Aged, Aged, 80 and over, Cardiovascular Diseases/epidemiology, Cardiovascular disease (CVD), Middle Aged, Prognosis, cardiovascular outcomes, Survival Rate, Cardiovascular death, incidence, Female, Adrenocortical Adenoma/physiopathology, Morbidity, Follow-Up Studies
Abstract

Context: While adrenal adenomas have been linked with cardiovascular morbidity in convenience samples of patients from specialized referral centers, large-scale population-based data are lacking. Objective: To determine the prevalence and incidence of cardiometabolic disease and assess mortality in a population-based cohort of patients with adrenal adenomas. Design: Population-based cohort study. Setting: Olmsted County, Minnesota, USA. Patients: Patients diagnosed with adrenal adenomas without overt hormone excess and age- and sex-matched referent subjects without adrenal adenomas. Main outcome measure: Prevalence, incidence of cardiometabolic outcomes, mortality. Results: (Adrenal adenomas were diagnosed in 1004 patients (58% women, median age 63 years) from 1/01/1995 to 12/31/2017. At baseline, patients with adrenal adenomas were more likely to have hypertension [adjusted odds ratio (aOR) 1.96, 95% CI 1.58-2.44], dysglycemia (aOR 1.63, 95% CI 1.33-2.00), peripheral vascular disease (aOR 1.59, 95% CI 1.32-2.06), heart failure (aOR 1.64, 95% CI 1.15-2.33), and myocardial infarction (aOR 1.50, 95% CI 1.02-2.22) compared to referent subjects. During median follow-up of 6.8 years, patients with adrenal adenomas were more likely than referent subjects to develop de novo chronic kidney disease [adjusted hazard ratio (aHR) 1.46, 95% CI 1.14-1.86], cardiac arrhythmia (aHR 1.31, 95% CI 1.08-1.58), peripheral vascular disease (aHR 1.28, 95% CI 1.05-1.55), cardiovascular events (aHR 1.33, 95% CI 1.01-1.73), and venous thromboembolic events (aHR 2.15, 95% CI 1.48-3.13). Adjusted mortality was similar between the 2 groups. Conclusion: Adrenal adenomas are associated with an increased prevalence and incidence of adverse cardiometabolic outcomes in a population-based cohort.

Published
2021

292. Adrenal venous sampling for lateralization of cortisol hypersecretion in patients with bilateral adrenal masses.

Author

Johnson, Paige C., Thompson, Scott M., Adamo, Daniel, Fleming, Chad J., Bancos, Irina, McKenzie, Travis J., Cheville, John, Young, William F., and Andrews, James C.

Subjects
HYDROCORTISONE, ADRENAL insufficiency, VENA cava inferior
Abstract

Objective: The objective of this study was to evaluate the role of adrenal venous sampling (AVS) in guiding the management of patients with corticotropin (ACTH)‐independent glucocorticoid secretory autonomy and bilateral adrenal masses. Design and Patients: A cohort with 25 patients underwent AVS and surgical management. Measurements: Cortisol was measured from the adrenal veins (AVs) and inferior vena cava (IVC). AV/IVC cortisol ratio and cortisol lateralization ratio (CLR) (dominant AV cortisol concentration divided by the nondominant AV cortisol concentration) were calculated. Posthoc receiver‐operating characteristic curves were generated to determine the specificity of revised AV/IVC cortisol ratio and CLR in differentiating unilateral from bilateral disease. Results: Patients underwent unilateral (n = 21) or bilateral (n = 4) adrenalectomy. The mean AV/IVC cortisol ratio for unilateral adrenalectomy was 12.1 ± 9.6 (dominant) and 4.7 ± 3.8 (contralateral) with a mean CLR of 3.6 ± 3.5. The mean AV/IVC cortisol ratio for bilateral adrenalectomy was 7.5 ± 2.1, with a mean CLR of 1.1 ± 0.6. At a mean follow‐up of 22 months, one patient who underwent unilateral adrenalectomy for the predicted bilateral disease developed recurrent mild autonomous cortisol secretion. Posthoc analyses demonstrated a specificity of 95%–100% for unilateral disease with AV/IVC cortisol ratio >9 for one side, <2.0 for the opposite side and a CLR > 2.3. The specificity was 80%–90% for bilateral disease with AV/IVC cortisol ratio >5.1 bilaterally and a CLR < 1.1. Conclusions: Among patients with bilateral adrenal masses and ACTH‐independent autonomous cortisol secretion, AVS can distinguish between unilateral and bilateral disease with high specificity and may guide surgical management. [ABSTRACT FROM AUTHOR]

Published
2023
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294. Clinical, imaging and biochemical presentation of cystic pheochromocytomas.

Author

Dogra, Prerna, Navin, Patrick J., McKenzie, Travis J., Foster, Trenton, Dy, Benzon, Lyden, Melanie, Young, William F., and Bancos, Irina

Subjects
ADRENAL tumors, COMPUTED tomography, PHEOCHROMOCYTOMA, ADRENALECTOMY
Abstract

Objective: Cystic adrenal mass is a rare imaging presentation of pheochromocytoma. We aimed to describe the clinical, biochemical and imaging characteristics of patients with cystic pheochromocytoma. Design: Single‐centre, retrospective study, 2000−2020. Patients: Consecutive patients with cystic pheochromocytoma were identified from our institutional pathology and adrenal tumour database. Results: Of the 638 patients with pheochromocytomas, 21 (3.2%) had cystic pheochromocytomas (median age: 57 years, 57% women). Most pheochromocytomas were discovered incidentally (57%) or due to symptoms of catecholamine excess (24%). The median tumour size was 6.4 cm. On imaging, cystic pheochromocytomas were round or oval (90%), heterogeneous lesions (86%) with a thick solid rim (median rim thickness 13.9 mm, unenhanced computed tomography (CT) attenuation 40 Hounsfield units (HU), venous‐phase CT attenuation 83 HU), and a median cystic component of 40% (unenhanced CT attenuation 17.6 HU, venous‐phase CT attenuation 20.4 HU), and rarely with calcifications (15%). All 20 patients with biochemical testing had functioning tumours (adrenergic in 80%, noradrenergic in 20%). Total urinary metanephrine excretion correlated with the volume of the solid component (R2 =.75, p <.0001) but not the cystic component (R2 =.04, p =.4386). All patients underwent adrenalectomy (48% laparoscopic, 52% open), and the median duration of hospital stay was 4 days. Conclusions: Cystic pheochromocytomas are rare, large tumours with a phenotypic appearance that can masquerade as other adrenal cystic lesions. The degree of biochemical abnormality in cystic pheochromocytomas is associated with the volume of the solid component. All patients with adrenal cysts that have a solid component or an unenhanced attenuation >10 HU should undergo biochemical testing for pheochromocytoma. [ABSTRACT FROM AUTHOR]

Published
2023
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296. Cytoreductive Surgery of the Primary Tumor in Metastatic Adrenocortical Carcinoma: Impact on Patients’ Survival

Author

Srougi, Victor, primary, Bancos, Irina, additional, Daher, Marilyne, additional, Lee, Jeffrey E, additional, Graham, Paul H, additional, Karam, Jose A, additional, Henriquez, Andres, additional, Mckenzie, Travis J, additional, Sada, Alaa, additional, Bourdeau, Isabelle, additional, Poirier, Jonathan, additional, Vaidya, Anand, additional, Abbondanza, Tiffany, additional, Kiernan, Colleen M, additional, Rao, Sarika N, additional, Hamidi, Oksana, additional, Sachithanandan, Nirupa, additional, Hoff, Ana O, additional, Chambo, Jose L, additional, Almeida, Madson Q, additional, Habra, Mouhammed Amir, additional, and Fragoso, Maria C B V, additional

Published
2021
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298. Abnormal body composition in patients with adrenal adenomas

Author

Delivanis, Danae A, primary, Hurtado Andrade, Maria D, additional, Cortes, Tiffany, additional, Athimulam, Shobana, additional, Khanna, Aakanksha, additional, Atkinson, Elizabeth, additional, McKenzie, Travis, additional, Takahashi, Naoki, additional, Moynagh, Michael R, additional, and Bancos, Irina, additional

Published
2021
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