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260. Effect of magnesium compounds on crystal structure, morphology, and electrochemical properties of LiFePO4/C.

Author

Mao, Huiqian, Chen, Kui, Luo, Xianming, Wu, Bin, Qu, Mingjun, Xu, Yiming, and Zou, Gongsheng

Abstract

The mechanism of magnesium compounds on the crystal structure, morphology, and electrochemical properties of LiFePO4 has been investigated using magnesium oxide, magnesium sulfate, and magnesium hydrogen phosphate as dopants. The shrinkage of crystal cell and lattice spacing implies that Mg2+ is successfully doped into the lattice of LiFePO4, since magnesium ions occupy less space than ferrous ions or lithium ions. Meanwhile, the primary particle size of LiFePO4 tends to reduce when high-content magnesium is doped, which is ascribed to cell shrinkage as well as the reduction of surface energy. In addition, agglomeration of crystal fine particles is observed in the SEM images. The discharge capacity of 1%MgHPO4-LFP increases as the proceeding of the charging/discharging cycle; i.e., the retention rate of this sample exceeds 100% (100.96%) at 0.5 C after 30 cycles. Owing to the substitution of S for O sites, the diffusion channel of Li+ expands while the total number of Fe-Li reverse site defects decreases, which lowers the capacity attenuation of 10%MgSO4-LFP under high-rate conditions (compared to 10%MgO-LFP). The discharge capacity of 10%MgSO4-LFP is 88.7 mAh/g, which is higher than 10%MgO-LFP (75.06 mAh/g). [ABSTRACT FROM AUTHOR]

Published
2023
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290. High-Throughput and Efficient Intracellular Delivery Method via a Vibration-Assisted Nanoneedle/Microfluidic Composite System

Author

Li, Xuan, primary, Ma, Yuan, additional, Xue, Yu, additional, Zhang, Xuanhe, additional, Lv, Linwen, additional, Quan, Qianghua, additional, Chen, Yiqing, additional, Yu, Guoxu, additional, Liang, Zhenwei, additional, Zhang, Xinping, additional, Weng, Ding, additional, Chen, Lei, additional, Chen, Kui, additional, Han, Xin, additional, and Wang, Jiadao, additional

Published
2022
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298. Repositioning application of polyoxyethylene (20) sorbitan monooleate on ocular drug resistance and cancer multi-drug resistance by inhibiting the ATPase activity of human multidrug resistance protein 1 and P-glycoprotein

Author

Yu-Ning, Teng, Li-Hung, Chen, and Yi-Hung, Chen Kui Vavulengan

Subjects
Adenosine Triphosphatases, ATP Binding Cassette Transporter, Subfamily B, Polysorbates, Pharmaceutical Science, Antineoplastic Agents, Retinal Pigment Epithelium, General Medicine, Drug Resistance, Multiple, Molecular Docking Simulation, Drug Resistance, Neoplasm, Cell Line, Tumor, Humans, Multidrug Resistance-Associated Proteins, Biotechnology
Abstract

Drug efflux transporters were highly related to the clinical drug resistance issues, such as cancer multi-drug resistance (MDR) and ocular drug resistance. In the present study, with the focus on human multi-drug resistance protein 1 (MRP1) and P-glycoprotein (P-gp), the inhibitory kinetics of polyoxyethylene (20) sorbitan monooleate (Tween 80) on both drug binding sites and ATPase were in-depth evaluated. We used the stable-cloned ABCB1/Flp-In™-293 and ABCC1/Flp-In™-293 cell lines, and inside-out membrane vesicles for underlying mechanisms investigation while used the drug induced cancer MDR cell line KB/VIN and human retinal pigmented epithelium cell line ARPE-19 for efficacy evaluation. Results showed that Tween 80 exhibited non-competitive inhibition on the doxorubicin efflux of P-gp and MRP1, with the inhibitory affinity 0.00195% (14.89 μM) and 0.00245% (18.7 μM), respectively. Tween 80 inhibited the basal ATPase activity of P-gp and MRP1 in a dose-dependent manner (0.0002-0.02%) and demonstrated significant reversing effects on the doxorubicin, paclitaxel, and vincristine resistance at the concentration of 0.001% (7.63 μM). This was the first thorough study revealing the interactions between Tween 80 and P-gp or MRP1 at a molecular level and these findings suggested that Tween 80 was a potential candidate for future combinatorial regimens applied in the "drug resistance" issue.

Published
2022

300. Rheo-XPCS

Author

Leheny, Robert L., Rogers, Michael C., Chen, Kui, Narayanan, Suresh, and Harden, James L.

Published
2015
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