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Despite the efforts focused on manufacturing biological engineering scaffolds for tissue engineering and regenerative medicine, a biomaterial that meets the necessary characteristics for these applications has not been developed to date. Bacterial nanocellulose (BNC) is an outstanding biomaterial for tissue engineering and regenerative medicine; however, BNC's applications have been focused on two-dimensional (2D) medical devices, such as wound dressings. Given the need for three-dimensional (3D) porous biomaterials, this work evaluates two methods to generate (3D) BNC scaffolds. The structural characteristics and physicochemical, mechanical, and cell behaviour properties were evaluated. Likewise, the effects of the pore size and surface area in the mechanical performance of BNC biomaterials and their cell response in a fibroblast cell line are discussed for the first time. In this study, a new method is proposed for the development of 3D BNC scaffolds using paraffin wax. This new method is less time-consuming, more robust in removing the paraffin and less aggressive toward the BNC microstructure. Moreover, the biomaterial had regular porosity with good mechanical behaviour; the cells can adhere and increase in number without overcrowding. Regarding the pore size and surface area, highly interconnected porosities (measuring approximately 60 μm) and high surface area are advantageous for the biomaterial's mechanical properties and cell behaviour. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 348-359, 2019.

Topographic mapping in Brazil has been performed without the direct application of cartographic theory to reflect local conditions. This problem is even more pronounced regarding large-scale mappin...

Introducción: El vértigo y mareo ocupan el 20-30% de la consulta general, predominantemente adultos mayores. En Colombia no hay estudios sobre las características de los pacientes con alteraciones del equilibrio y en la literatura mundial son escasos. El diagnóstico y tratamiento pueden lograrse con una historia clínica detallada y examen otoneurológico enfocado. Objetivo: Describir las características clínicas y sociodemográficas de los pacientes de la consulta de Vértigo y alteraciones del Equilibrio de la Clínica Occidente de Otorrinolaringología (Medellín, Colombia) durante 01/10/2010- 31/03/2013. Métodos: Se realizó un estudio descriptivo, retrospectivo con pacientes ≥18 años de la consulta. Las principales variables fueron sexo, edad, características clínicas y mejoría. Resultados: Se obtuvieron datos de 134 pacientes, con edad media de 57.43 años, 76.9% mujeres. 85.8% refirieron vértigo, 68.7% desequilibrio y 46.3% sensación de cabeza abombada. La mediana del tiempo de evolución fue 36 meses (P25:6,P75:120). 53% usó vestibulosupresores ≥3 meses antes de consultar y 81.3% en los tres meses previos. Los diagnósticos definitivos fueron vértigo posicional paroxístico benigno 38.8%, vértigo asociado a vestibulosupresores 25.4%, vértigo asociado a migraña 7.5%, enfermedad de Ménière 5.2% y otros 23.1%. 71.6% suspendieron los vestibulosupresores. Conclusiones: El sexo femenino es predominante. Fue frecuente evidenciar curso crónico y consumo de vestibulosupresores, demostrando que su uso indiscriminado afecta el diagnóstico, evolución y mejoría. Los diagnósticos fueron vértigo posicional paroxístico benigno, vértigo asociado a vestibulosupresores, siendo el desequilibrio el síntoma predomimante a diferencia de los demás, donde fue el vértigo. Debe investigarse más para evaluar indicadores de mejoría en vértigo.

The occurrence of mycotoxins synthesized by spoilage fungi has been reported in various crops. Despite being a crop susceptible to attack by microorganisms, such as Alternaria alternata, there are no reports on the production of mycotoxins in Hylocereus undatus (Haw.). The objective of the present study was to identify mycotoxins produced by A. alternata previously isolated from Hylocereus undatus (Haw.) fruit in the postharvest phase, and A. alternata ATCC 46,582, in vitro and in vivo. The compounds were identified using liquid chromatography-mass spectrometry (LC–MS/MS). Alternariol (AOH), alternariol monomethyl ether (AME), tentoxin (TEN), altertoxins (ATX) I, II and III were detected in vitro for A. alternata, and ATX I and II were identified for the reference strain, A. alternata ATCC 46,582, which was used as a positive control. Mycotoxins characteristic of A. alternata were not detected in vivo in the fruit stored for 8 d, which is its estimated shelf life. The use of LC–MS/MS facilitated rapid and efficient mycotoxin identification, contributing significantly to the evaluation of food safety.

Variation in dorsal fin morphology was assessed in five common bottlenose dolphin populations from the Southeast Pacific. We hypothesized that habitat specialization between coastal and offshore ecotypes would lead to differences in dorsal fin morphology. Photographs and direct measurements of dorsal fins were used to calculate three indexes: height/length base (h/b), width at half height/length base (a/b), and overhang of the dorsal fin tip/length base (falcateness) (s/b). The sample included 163 individuals (129 coastal and 34 offshore) from Ecuador, 60 individuals (nine coastal and 51 offshore) from Peru, and 25 individuals of an inshore community occurring in north-central Chile (Pod-R). Ontogenetic variation was found in coastal dolphins from Ecuador, where sex and age classes were best represented. A statistically significant difference was found in the a/b index between coastal specimens from Ecuador and Peru and among the three offshore groups. When offshore and Pod-R data were pooled and compared with data from coastal specimens from Ecuador and Peru, a significant difference was found in the s/b index. Overall, dorsal fins of offshore dolphins are relatively higher than fins of coastal individuals. However, the most consistent difference between ecotypes was the strong falcateness (high s/b) in offshore forms versus a more triangular shape (low s/b) in coastal forms. We propose that dorsal fin falcateness is a reliable criterion to visually distinguish between bottlenose dolphin ecotypes in this region. Proper identification in the field greatly facilitates research and helps focus management needs of the different bottlenose dolphin populations.

Resumen Objetivo Evaluar la asociacion de la situacion funcional previa, valorada mediante la escala de Barthel y Short Form-Late Life Function and Disability instrument, en los pacientes mayores de 74 anos que precisan de ingreso en la UCI con respecto a su pronostico y capacidad funcional al alta hospitalaria. Material y metodos Estudio prospectivo de una cohorte de paciente mayores de 74 anos ingresados en UCI polivalente con estancia superior a 48 h. Se analizan variables demograficas, sociales, comorbilidad, cuestionario de discapacidad (Barthel, Short Form-Late Life Function and Disability instrument), motivos de ingreso en UCI, gravedad en UCI (SAPS 3). Se realiza un analisis multivariable para establecer los factores asociados a mortalidad o mala situacion funcional al alta (indice de Barthel menor de 35). Resultados Durante el periodo del estudio ingresaron 219 pacientes mayores de 74 anos, de los que 129 (15%) tuvieron estancia mayor de 48 h. La mediana de edad fue de 80 anos (77-83) siendo el 52% mujeres. El motivo de ingreso fue cardiopatia isquemica (19%), otra patologia medica (38%) y patologia quirurgica (43%). Un 3% de los pacientes presentaba un Barthel inferior a 36 a su ingreso, siendo la mediana de 95 (85-100). La mediana de estancia en UCI fue de 5 dias (4-8). La mortalidad en UCI fue del 6%, con una mortalidad hospitalaria del 10%. Al alta hospitalaria el 7% presentaban dependencia grave (Barthel inferior a 36). En esta poblacion los factores asociados de forma independiente con la mortalidad o mala situacion funcional al alta del hospital fueron la situacion funcional previa al ingreso, en base a Short Form-Late Life Function and Disability instrument (OR 0,95 IC95%; 0,91 a 0,98); y a la gravedad al ingreso evaluada por SAPS 3 (OR 1,10 IC95%; 1,02 a 1,18) p=0,0007. Conclusiones En pacientes ancianos que precisan ingreso en UCI, presentar una mayor puntuacion en la escala SAPS 3 y deterioro funcional en base a una escala son factores asociados a mortalidad o dependencia severa al alta.

Middle ear actinomycosis is an atypical and exceedingly rare anaerobic infection. The authors report a case of a 7-year-old girl with persistent right side otalgia, conductive hearing loss, and headache. Otoscopic findings included a thickened, intact, and bulging tympanic membrane. Computed tomography imaging revealed soft tissue density filling the middle ear with areas of bone erosion. Typical sulfur granules were found on surgical exploration. Actinomycosis was diagnosed by histopathological examination. Penicillin was prescribed for 5 weeks followed by oral amoxicillin for 6 months. Recovery was uneventful and with a 2-year follow-up, no recurrence or complications were observed.

Background Compared with conventional haemodialysis (HD), online haemodiafiltration (OL-HDF) achieves a more efficient removal of uraemic toxins and reduces inflammation, which could favourably affect nutritional status. We evaluate the effect of OL-HDF on body composition and nutritional status in prevalent high-flux HD (HF-HD) patients. Methods In all, 33 adults with chronic kidney disease (CKD) Stage 5 undergoing maintenance HF-HD were assigned to post-dilution OL-HDF (n = 17) or to remain on HF-HD (n = 16, control group) for 12 months. The primary outcome was the change in lean tissue mass (LTM), intracellular water (ICW) and body cell mass (BCM) assessed by multifrequency bioimpedance spectroscopy (BIS) at baseline and 4, 8 and 12 months. The rate of change in these parameters was estimated with linear mixed-effects models. Results Compared with OL-HDF, patients assigned to HF-HD experienced a gradual reduction in LTM, ICW and BCM. These differences reached statistical significance at Month 12, with a relative difference of 7.31 kg [95% confidence interval (CI) 2.50-12.11; P = 0.003], 2.32 L (95% CI 0.63-4.01; P = 0.008) and 5.20 kg (95% CI 1.74-8.66; P = 0.004) for LTM, ICW and BCM, respectively. The normalized protein appearance increased in the OL-HDF group compared with the HF-HD group [0.26 g/kg/day (95% CI 0.05-0.47); P = 0.002], with a relative reduction in high-sensitive C-reactive protein [-13.31 mg/dL (95% CI -24.63 to -1.98); P = 0.02] at Month 12. Conclusions OL-HDF for 1 year compared with HF-HD preserved muscle mass, increased protein intake and reduced the inflammatory state related to uraemia and dialysis, supporting the hypothesis that high convection volume can benefit nutritional status and prevent protein-energy wasting in HD patients.

A boy aged 1 year, recently diagnosed with dilated cardiomyopathy, has to be treated with enalapril according to the heart failure protocol. The physician wants to know which adverse events she can expect. What are the potential adverse events related to administration of an ACE inhibitor to children with heart failure? What is the prevalence and what are the possible risk factors? Secondary sources—nil Electronic databases (PubMed/Medline and Embase) and reference lists of relevant articles were searched with the following strategy: ‘angiotensin-converting enzyme inhibitors’ and ‘heart failure’ and ‘children’. The search yielded 415 individual articles, of which 14 were identified as relevant. Heart failure is an important cause of morbidity and mortality in children.1 It is commonly treated with ACE inhibitors (ACE-i) despite the lack of evidence on its efficacy.2 This treatment is based on the assumption that blocking of the renin-angiotensin-aldosterone system has a positive effect on morbidity and mortality, as it does in adults with heart failure.3–6 In adults, the most prevalent adverse events (AEs) related to the use of ACER-i are renal failure,7 8 hypotension,9 10 hyperkalemia,9 11 cough12 and angioedema.13 It is assumed that the safety profile of ACE-i differs for children and differs from that for adults, and for children of different ages, as growth and development contribute to variation in the disposition and effect of most drugs administered …

A crise mundial da água não se limita em sua disponibilidade, mas também na qualidade da água superficial, que embora em abundância em certas regiões, não é devidamente preservada. A APA do rio Uberaba foi criada principalmente para manutenção dos recursos hídricos para abastecimento público. Contudo, observa-se mudanças no uso e ocupação do solo, resultado da expansão agropecuária nos últimos anos, aumentando a fragmentação florestal, o que favorece o assoreamento e compromete a disponibilidade de água. Assim, o presente estudo realizou o diagnóstico ambiental da microbacia do Mutum, inserida na APA, por meio de biomonitoramento com macroinvertebrados bentônicos, análises visuais, microbiológicas e físico-químicas. Os valores dos parâmetros físico-químicos não ultrapassaram os limites estabelecidos para rios de classe II, com exceção dos metais: Cd, Cu, Fe e Ni, os quais podem ser oriundos de disposição inadequada de resíduos, lixiviação de agrotóxicos e tipo de rocha. A degradação ambiental foi constatada pela aplicação do Protocolo de Avaliação Rápida de Rios (PAR) e confirmada pela presença de E. coli nas amostras de água e pela avaliação dos macroinvertebrados bentônicos. Os índices biológicos mostraram baixa diversidade de táxons e elevada dominância de quironomídeos, larvas de insetos resistentes a estresses ambientais. O ponto com maior estabilidade das margens e proteção pela vegetação ripária apresentou os melhores índices biológicos. Por se tratar de uma Unidade de Conservação de uso sustentável, constituída por propriedades privadas, a qualidade ambiental deve ser monitorada e incentivada na região para que a APA possa manter os serviços ambientais prestados.

EnglishCapitalist society implies thinking about the type of education that the school under the principles of this system imposes on class society. From a bibliographic review on concepts of Historical-Dialectic Materialism and Historical-Critical Pedagogy, an analysis of the reality of the current school was sought in order to contribute with some findings about its function and the teacher’s role, for its possible transformation. The objective is to describe the social function of education in the capitalist school, with brief considerations about its intentionality in the history reproduced in the teaching work. The text presents concepts that, in their entirety, establish the principles that guide this conception of education and teaching, based on the formation of theoretical thinking, namely: capitalist society, education, school, teacher, theoretical thinking, among other concepts. It bases the conceptual field of the teacher and the school from the systematization and analysis of these concepts and the intrinsic relations to them. It is concluded that an “exercise” was carried out on the need to reflect and raise awareness about the educational possibilities of the student through a critical view of the current society, as well as, to verify the limiting conditions that the school proposes to its students, hindering their transformation and humanization and, in a way, preparing for the economic adjustment of capital, through the labor force. portuguesA sociedade capitalista infere a pensar no tipo de educacao que a escola sob os principios desse sistema impoe para a sociedade de classes. A partir de uma revisao bibliografica sobre conceitos do Materialismo Historico-Dialetico e da Pedagogia Historico-Critica, buscou-se a analise da realidade da escola atual com vistas a contribuir com algumas constatacoes acerca da sua funcao e no papel do professor, para a sua possivel transformacao. O objetivo e o de descrever a funcao social da educacao na escola capitalista, com breves consideracoes sobre a sua intencionalidade na historia reproduzida no trabalho docente. O texto apresenta conceitos que, em sua totalidade, estabelecem os principios que orientam essa concepcao de educacao e de ensino, baseados na formacao do pensamento teorico, a saber: sociedade capitalista, educacao, escola, professor, pensamento teorico, entre outros conceitos. Fundamenta o campo conceitual do professor e da escola a partir da sistematizacao e analise desses conceitos e das relacoes a eles intrinsecas. Conclui-se que foi realizado um exercicio sobre a necessidade de refletir e conscientizar sobre as possibilidades educativas do aluno por meio de uma visao critica da sociedade atual, assim como, constatar as condicoes limitantes que a escola propoe aos seus educandos, dificultando sua transformacao e humanizacao e, de certa forma, preparando para o ajustamento economico do capital, por meio da forca de trabalho.

Introdução: Denomina-se parada cardiorrespiratória (PCR) como a ausência de batimentos cardíacos e apneia. Esse quadro é classificado como uma condição clínica grave que é cada vez mais incidente nas Unidades de Terapia Intensiva, por esse motivo, os profissionais de saúde precisam ser preparados para atuar nesse contexto. Objetivo: Analisar os casos de parada cardiorrespiratória em diferentes setores da assistência. Metodologia: Realizada busca pela Biblioteca Virtual de Saúde (BVS), no mês de julho de 2021. Iniciou-se a busca de materiais que contivessem em seu resumo os descritores em ciências da saúde (DeCS) Enfermeiro; Parada cardíaca; Unidade de Terapia Intensiva. Foi usado o boleador "and" e adotados os seguintes critérios para seleção dos artigos: materiais completos, em língua portuguesa, no formato de artigo e com recorte temporal de dez anos (2011-2021). Resultados: Foram analisados três artigos e a partir da leitura minuciosa foi elaborada a categoria com a temática “Atribuições e desafios encontrados por profissionais de enfermagem no momento da RCP”. Considerações Finais: Os problemas diários vividos por profissionais enfermeiros na assistência às vítimas de PCR são vários e entre eles acentua-se a escassez de qualificação dos trabalhadores, a carência de investimentos em educação permanente e a falta de suporte rápido, padronizado e de alta qualidade, são condições que possuem um alto perigo de obstáculos e até morte.

The aim of the present study is to evaluate the periodontal clinical and microbiologic responses and possible adverse effects of clarithromycin (CLM) combined with periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis.Forty patients were selected and randomly assigned into one of two groups: 1) CLM (n = 20): one-stage full-mouth ultrasonic debridement (FMUD) associated with CLM (500 mg, every 12 hours for 3 days); and 2) placebo (n = 20): FMUD associated with placebo pills. Clinical and microbiologic parameters were evaluated at baseline and 3 and 6 months postoperatively.Both treatments presented statistically significant clinical and microbiologic improvements. However, the CLM group presented lower means of probing depth for pockets ≥7 mm at 6 months (4.0 ± 1.7 mm) compared with the placebo group (4.7 ± 1.3 mm) (P = 0.04). In addition, the CLM group also presented greater reduction of Porphyromonas gingivalis (Pg) DNA counts at 6 months (P = 0.0001).Results from this study suggest both treatments are effective; however, adjunct use of CLM to FMUD leads to better reduction of deep pockets and Pg at 6 months compared with FMUD alone.

Objective To evaluate the construct validity (hypotheses testing) of the Chilean-Spanish version of the Functional Status Score for the Intensive Care Unit (FSS-ICU) using continuous actigraphy from intensive care unit (ICU) admission to ICU discharge. Design The Chilean-Spanish version of the FSS-ICU was used in a prospective observational study to mainly evaluate its correlation with actigraphy variables. The FSS-ICU was assessed on awakening and at ICU discharge, while actigraphy variables were recorded from ICU admission to ICU discharge. Setting A 12-bed academic medical-surgical ICU. Participants Mechanically ventilated patients (N=30), of 92 patients screened. Interventions Not applicable. Main Outcome Measures Construct validity of the FSS-ICU Chilean-Spanish version was assessed by testing 12 hypotheses, including the correlation with activity counts, activity time (>99 counts/min), inactivity time (0-99 counts/min), muscle strength, ICU length of stay, and duration of mechanical ventilation. Results The median FSS-ICU was 19 points (interquartile range [IQR], 10-26 points) on awakening and 28.5 points (IQR, 22-32 points) at ICU discharge. There was no floor/ceiling effect of the FSS-ICU at awakening (0%/0%) and only a ceiling effect at ICU discharge that was acceptable (0%/10%). Less activity time was associated with better mobility on the FSS-ICU at both awakening (ρ=−0.62, P Conclusions The Chilean-Spanish FSS-ICU had a strong correlation with inactivity time during the ICU stay. These findings enhance the available clinimetric properties of the FSS-ICU.

Background The Functional Status Score for the Intensive Care Unit (FSS-ICU) is a widely used instrument, designed to measure the mobility of critically ill patients that is available in English, Portuguese, Turkish and Spanish. The lack of a gold standard for measuring mobility limits the validation of outcome measures. However, actigraphy, from which measures movement intensity can be derived, is a potential alternative in the intensive care unit (ICU). Thus, this study aimed to assess the construct validity (hypotheses testing) of the FSS-ICU using continuous actigraphy from ICU admission to ICU discharge. Methods This prospective observational study included mechanically-ventilated patients selected from a 12-bed academic medical-surgical ICU. The Chilean-Spanish version of the FSS-ICU was used to evaluate its correlation with activity counts, activity time (>99 counts per minute) and inactivity time (0-99 counts per minute) measured by actigraphy ( GT9X Link ActiGraph). The FSS-ICU was assessed on awakening and at ICU discharge, while actigraphy variables were recorded from ICU admission to ICU discharge. Results Of 92 patients screened, 30 were analysed. The median FSS-ICU was 19 (IQR 10–26) points on awakening and 28.5 (IQR 22–32) at ICU discharge. There was no floor/ceiling effect of the FSS-ICU at awakening (0%/0%) and only a ceiling effect at ICU discharge that was acceptable (0%/10%). Less activity time was associated with better mobility on the FSS-ICU at both awakening (rho = -0.62, P

In the present study, the biological activity of an extract of the secondary metabolites (E-G6-32) produced by the

The use of rosemary essential oil (RO) and its combination with nisin (RO+N) in preventing the multiplication of Alicyclobacillus acidoterrestris in orange juice was evaluated. The minimum inhibitory and bactericidal concentrations (MIC and MBC) for RO were both 125 μg ml-1 while RO+N displayed a synergistic effect. The use of RO and RO+N at concentrations of 1, 4 and 8× MIC in orange juice for 96 h was evaluated in terms of their sporicidal effectiveness. With regard to the action against A. acidoterrestris spores, RO at 8× MIC was sporostatic, whereas RO+N at 1× MIC was sporicidal. Morphological changes in the structure of the micro-organism after treatment were also observed by microscopy. Furthermore, flow cytometric analysis showed that most cells were damaged or killed after treatment. In general, the antioxidant activity after addition of RO+N decreased with time. The results demonstrate that using the combination of RO and nisin can prevent the A. acidoterrestris growth in orange juice.

In this study, the effect of bioreactor size was evaluated with respect to the production and characteristics of the nanocellulose membranes produced by two different bioreactors: one with an 1800 cm2 cross-sectional area (BC-B44) and a lab-scale bioreactor with a 41 cm2 cross-sectional area (BC-B1). The culture conditions were kept the same, and the substrate consisted of overripe bananas, which are inexpensive because they are unsuitable for human consumption. The X-ray diffraction pattern showed that the two samples had similar crystalline structures, but changes were observed at the morphological level in the nanofibers that make up the BNC membranes. These changes generated, in turn, variations in the mechanical and thermal properties of the samples. This result represents a novel scale-up effect related to the static mode fermentation of BNC.

Submitted by denison pereira (denison.rolim@uniceub.br) on 2021-01-27T16:51:25Z No. of bitstreams: 1 Gabriela Hott.pdf: 263505 bytes, checksum: 22a20f7f4e545fce99e66b32dc90b704 (MD5) Approved for entry into archive by Heres Pires (heres.pires@uniceub.br) on 2021-04-29T11:53:54Z (GMT) No. of bitstreams: 1 Gabriela Hott.pdf: 263505 bytes, checksum: 22a20f7f4e545fce99e66b32dc90b704 (MD5) Made available in DSpace on 2021-04-29T11:53:54Z (GMT). No. of bitstreams: 1 Gabriela Hott.pdf: 263505 bytes, checksum: 22a20f7f4e545fce99e66b32dc90b704 (MD5) Previous issue date: 2021-01-27 Objetivo da pesquisa foi compreender os aspectos socioemocionais que envolvem a mulher mastectomizada e seus principais cuidados de enfermagem. Trata-se de uma revisão narrativa realizada nos meses de março e abril de 2020 por meio de pesquisa eletrônica em bases de dados nos últimos 10 anos. Para facilitar o entendimento sobre a temática, optou-se por distribuir os resultados em três categorias: 1) A mastectomia; 2) Aspectos socioemocionais que envolvem a mulher mastectomizada; 3) Cuidados socioemocionais de enfermagem à mulher mastectomizada. Conclui-se que esse artigo é de extrema relevância para os profissionais de enfermagem. A partir dele, percebeu-se a necessidade de adquirir conhecimentos sobre as questões socioemocionais que envolvem a mulher mastectomizada e implementar cuidados de enfermagem que vão além dos cuidados fisiológicos à essa mulher. Observa-se, também, a necessidade de novas pesquisas no âmbito a enfermagem que reflitam os cuidados em saúde mental a mulheres mastectomizadas para o melhor atendimento e qualidade de vida.

Recent advances in materials science and nanotechnology together with ecological awareness have increased interest in the development of green products. The biomedical industry is not an exemption and lignocellulosic biomaterials have become of great interest, given their inherent biocompatibility. Concurrently, they are part of bio-systems and offer great versatility as far as properties and availability. In their native state, lignocellulosic biomaterials, e.g., in wood, typically comprise cellulose (35–50 wt.%), hemicellulose (20–35 wt.%), and lignin (10–25 wt.%). For biomedical applications these three components are promising green resources. Since ancient times cellulose have been used in gauzes for treatment of wounds; presently, it offers a wide range of possibilities that have been opened by nanotechnologies. Cellulose assembly is similar to that of collagen, the major component of extracellular matrices, and its applications are diverse, ranging from three-dimensional scaffolds for tissue engineering, implants for cell regeneration, or cell labeling. Likewise, hemicelluloses bring their own potential, for example, in drug delivery systems where they excel in performance. Likewise, due to its chemical heterogeneity, lignin is an excellent source of bioactive components, displays antioxidant activity, and can be used in pathogen treatment. This chapter discusses some relevant biomedical applications of lignocellulosic biomaterials. It will also highlight applications of bacterial nanocellulose, which has the same chemical structure than vegetable cellulose, but brings some additional properties, especially those critical in biomedical fields. In the medium to long term, lignocellulosic biomaterials will play an important role for improving life quality, for helping in developing tissues and organs, and for accelerating healing processes.

La Vicerrectoria Academica de la Universidad Santo Tomas en Tunja, articulada con el Departamento de Ciencias Basicas, buscan seguir promoviendo espacios academicos que contribuyan a la transformacion del ser humano y que a su vez integren la region dentro del contexto cientifico del mundo, mediante el fomento y divulgacion de la ciencia; razon por la cual en sintonia con el Plan Integral Multicampus se han propuesto incorporar espacios academicos que respondan a los desafios de la globalizacion y que en paralelo involucren novedosas metodologias para el desarrollo del pensamiento y ensenanza de la ciencia. Con este fin se realizo el III Congreso Internacional de Ciencias Basicas, durante los dias 10, 11 y 12 de Abril de 2019 en el Centro de Convenciones de la Camara de Comercio de Tunja, como espacio de visibilidad, impacto nacional y global, que servira como pauta y herramienta fundamental de exploracion hacia nuevos metodos de ensenanza, actualizacion del conocimiento y trascendencia del mismo en el desarrollo del ser humano y su entorno, con enfoque en los problemas de la region, el pais y el mundo. Finalmente, es importante resaltar que el objetivo principal del congreso, fue generar un espacio academico de caracter internacional, que permitiera fortalecer la divulgacion cientifica de trabajos e investigaciones en Ciencias Basicas, que contribuyan al desarrollo del ser humano y su entorno, por lo cual dentro de este documento se encontraran trabajos entorno a la ensenanza de las Ciencias, la Fisica, Quimica y Biologia experimental, al igual que trabajos con respecto a la simulacion en Matematicas, Estadistica y aplicaciones.

Introduction: Death and dying are daily relevant themes for health care professionals and medical students. Nonetheless, since their first years of graduation, students are contrived to supplant the holistic conception of human beings and life in favor of enhancing the technical aspects of the medical profession. Methods: Therefore, in face of the few opportunities to enquire about these future professionals’ feelings and comprehensions toward life terminality, we pursued their perceptions through the application of a semi-structured questionnaire. Ten students from each year of the medical course at UNIVAS were interviewed, encompassing 60 scholars. Students should be regularly enrolled in the medical course, as well as give their consent, by signing the Consent Term, to participate in the study. The interviews took place at the institution and the material containing students’ responses was fully destroyed afterwards. Their responses were analyzed based on the Discourse of the Collective Subject Method. Results: The idea of terminality being properly the “end of life” was paramount among the years, situation with which a great amount of the scholars (58%) admitted not being prepared to deal with, due to the lack of reflections about death, its psychological aspects and repercussions in the academic context. Interestingly, about 16% of the scholars considered themselves prepared to deal with someone’s death, although they were not prepared to intervene in the actual process. This is reinforced by the fact that students must deal with the real scenario of giving undesirable news without previously being prepared to do so, by means of reflecting upon a hypothetical related to the “life-death binomial”. Conclusion: Thus, it seems necessary to create spaces in the curriculum that yield not only theoretical-practical but also affective support in situations related to terminality. The proposal of a theoretical-practical education based on palliative care amid the learning programs would shape confident attitudes of future health care professionals towards care.

Made available in DSpace on 2020-12-12T01:29:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01 Background: Supplementation with omega-3 polyunsaturated fatty acids (ω-3 PUFA) and low-dose aspirin (ASA) have been proposed as a host modulation regimen to control chronic inflammatory diseases. The aim of this study was to investigate the clinical and immunological impact of orally administered ω-3 PUFA and ASA as adjuncts to periodontal debridement for the treatment of periodontitis in patients type 2 diabetes. Methods: Seventy-five patients (n = 25/group) were randomly assigned to receive placebo and periodontal debridement (CG), ω-3 PUFA + ASA (3 g of fish oil/d + 100 mg ASA/d for 2 months) after periodontal debridement (test group [TG]1), or ω-3 PUFA + ASA (3 g of fish oil/d + 100 mg ASA/d for 2 months) before periodontal debridement (TG2). Periodontal parameters and GCF were collected at baseline (t0), 3 months after periodontal debridement and ω-3 PUFA + ASA or placebo for TG1 and CG (t1), after ω-3 PUFA + ASA (before periodontal debridement) for TG2 (t1), and 6 months after periodontal debridement (all groups) (t2). GCF was analyzed for cytokine levels by multiplex ELISA. Results: Ten patients (40%) in TG1 and nine patients (36%) in TG2 achieved the clinical endpoint for treatment (less than or equal to four sites with probing depth ≥ 5 mm), as opposed to four (16%) in CG. There was clinical attachment gain in moderate and deep pockets for TG1. IFN-γ and interleukin (IL)-8 levels decreased over time for both test groups. IL-6 levels were lower for TG1. HbA1c levels reduced for TG1. Conclusion: Adjunctive ω-3 and ASA after periodontal debridement provides clinical and immunological benefits to the treatment of periodontitis in patients with type 2 diabetes. Division of Periodontics Unesp – São Paulo State University Institute of Science and Technology Center for Clinical and Translational Research The Forsyth Institute Dental Research Division Guarulhos University Division of Periodontics Unesp – São Paulo State University Institute of Science and Technology

Objective: The aim of the present study was to design a content-valid nursing objective structured clinical examination attending a first-year clinical nursing practice program. Method: The examination was designed following a procedure based on the consensus of experts which was comprised of three phases: selection of the activities in which students should be competent according to the learning outcomes of the course, clinical case design, and integration of the clinical cases designed into the stations of the test. Results: Of the 44 surveys submitted for the design of the stations, 37 were answered, of which 31 respondents met the inclusion criteria of the panel of experts. The activities on which the experts reached the highest degrees of consensus were: basic physical assessment and monitoring of vital signs, assessment of hygiene and skin status, ability to develop care plans, management of safety principles in administration of medication and administration of oral medication. Based on the selected activities, the experts developed 20 clinical cases, from which a four-station nursing objective structured clinical examination was designed. Conclusion: The structured methodology based on the design of experts enabled the design of a content-valid objective structured clinical examination appropriate for the evaluation of the learning outcomes achieved by the students attending a clinical practice program. RESUMO Objetivo: O objetivo do presente estudo foi elaborar um exame clínico estruturado de objetivos de enfermagem com conteúdo válido, participando de um programa de prática clínica de enfermagem do primeiro ano. Método: O exame foi elaborado seguindo um procedimento baseado no consenso de especialistas que compreendeu três fases: seleção das atividades nas quais os alunos deveriam ser competentes de acordo com os resultados de aprendizagem do curso, desenho do caso clínico e integração do quadro clínico casos projetados para as estações do teste. Resultados: Das 44 pesquisas submetidas para a concepção das estações, 37 foram respondidas, das quais 31 respondentes atenderam aos critérios de inclusão do painel de especialistas. As atividades nas quais os especialistas alcançaram maior grau de consenso foram: avaliação física básica e monitoramento dos sinais vitais, avaliação da higiene e do estado da pele, capacidade de desenvolver planos de cuidados, gestão dos princípios de segurança na administração de medicamentos e administração de medicamentos orais. Com base nas atividades selecionadas, os especialistas desenvolveram 20 casos clínicos, a partir dos quais foi elaborado um exame clínico estruturado objetivo de enfermagem em quatro estações. Conclusão: A metodologia estruturada baseada na concepção de especialistas permitiu a concepção de um exame clínico estruturado objetivo válido e de conteúdo adequado para a avaliação dos resultados de aprendizagem alcançados pelos alunos que frequentam um programa de prática clínica. RESUMEN Objetivo: El objetivo de este estudio fue diseñar una Evaluación Clínica Objetiva Estructurada con validez de contenido para evaluar el nivel de competencias de estudiantes de primer curso de formación practico-clínica enfermera. Método: Se diseñó la prueba siguiendo un procedimiento basado en consenso de expertos con tres fases: selección de las actividades en la que los alumnos debían ser competentes en base a los resultados de aprendizaje de la asignatura, diseño de casos clínicos, e integración de los casos clínicos diseñados en las estaciones de la prueba. Resultados: Las actividades que alcanzaron mayor consenso por parte de los expertos fueron: valoración física básica y monitorización de signos vitales, valoración de la higiene y estado de la piel, capacidad para elaborar planes de cuidados, manejo de los principios de seguridad en la administración de medicación y administración de medicación oral. En base a las actividades seleccionadas, los expertos elaboraron 20 casos clínicos, a partir de los cuales se diseñó una evaluación clínica objetiva estructurada de cuidados de enfermería formada por cuatro estaciones. Conclusión: La metodología estructurada basada en el diseño de expertos permitió el diseño de una evaluación clínica objetiva estructurada adecuada para evaluar los resultados de aprendizaje alcanzados por los estudiantes de primer curso de formación práctico-clínica.