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252. Letter

Author

Deborah A. Wing and Richard H. Paul

Subjects
Obstetrics and Gynecology
Published
1996
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254. Oxygen concentration regulates EGF-induced proliferation and EGF-receptor down regulation

Author

Deborah A. Wing, Thomas G. Storch, and Glenda D. Talley

Subjects
Time Factors, Cell, Biophysics, chemistry.chemical_element, Biology, Biochemistry, Oxygen, Cell Line, Downregulation and upregulation, Epidermal growth factor, medicine, Humans, Fibroblast, Molecular Biology, Cells, Cultured, Dose-Response Relationship, Drug, Epidermal Growth Factor, DNA synthesis, Cell growth, Cell Biology, Cell biology, ErbB Receptors, medicine.anatomical_structure, chemistry, Limiting oxygen concentration, Cell Division, hormones, hormone substitutes, and hormone antagonists
Abstract

Reducing oxygen from 20% to 2.5% increases EGF-induced DNA synthesis and cell proliferation in cultures of human diploid fibroblasts. Reducing oxygen also changes the pattern of EGF binding to the cell surface. The loss of surface binding that follows EGF attachment to cells in 20% oxygen does not occur in 2.5% oxygen.

Published
1988
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