251. Association of single nucleotide polymorphisms in FOXE1 and pre-MIR146A with papillary thyroid carcinoma
- Author
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Nadia Bagatian, Mohammed H. Al-Qahtani, Hans-Juergen Schulten, Jaudah Al-Maghrabi, Adel M. Abuzenadah, Khalid A. Al-Ghamdi, Adeel G. Chaudhary, Osman Abdel Al-Hamour, Ohoud Subhi, and Shireen Hussain
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Genetics ,education.field_of_study ,Population ,Single-nucleotide polymorphism ,Biology ,Bioinformatics ,Thyroid carcinoma ,Polymorphism (computer science) ,Poster Presentation ,Genetic predisposition ,SNP ,education ,Allele frequency ,FOXE1 ,Biotechnology - Abstract
Background Papillary thyroid carcinoma (PTC) is one of the most common cancer types in the Middle East and North African (MENA) region and more abundant than in many other world regions suggesting that genetic susceptibility factors for this malignancy are likely to vary between the populations studied. We assessed in a population from the MENA region the allele frequencies of two SNPs which may bear the capacity to confer risk for developing PTC. SNP rs2910164 is a sequence polymorphism in the precursor microRNA (mir)146a. The heterozygous C/G state of rs2910164 was found to be associated with a reduced amount of mir146a which in turn had an effect on the efficiency to inhibit target genes as CCDC6 [1,2]. SNP rs1867277 is located 283 bp upstream of the translational start site of the developmental gene encoding forkhead box E1 (FOXE1) and identified as an associated risk factors for a number of solid tumors including PTC [3,4].
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