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9,743 results on '"Francis, David"'

255. Supplementary Figure Legends from Pan-HER Inhibitor Augments Radiation Response in Human Lung and Head and Neck Cancer Models

Author

Francis, David M., primary, Huang, Shyhmin, primary, Armstrong, Eric A., primary, Werner, Lauryn R., primary, Hullett, Craig, primary, Li, Chunrong, primary, Morris, Zachary S., primary, Swick, Adam D., primary, Kragh, Michael, primary, Lantto, Johan, primary, Kimple, Randall J., primary, and Harari, Paul M., primary

Published
2023
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264. Supplemental Figure 6 from In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments

Author

Morris, Zachary S., primary, Guy, Emily I., primary, Francis, David M., primary, Gressett, Monica M., primary, Werner, Lauryn R., primary, Carmichael, Lakeesha L., primary, Yang, Richard K., primary, Armstrong, Eric A., primary, Huang, Shyhmin, primary, Navid, Fariba, primary, Gillies, Stephen D., primary, Korman, Alan, primary, Hank, Jacquelyn A., primary, Rakhmilevich, Alexander L., primary, Harari, Paul M., primary, and Sondel, Paul M., primary

Published
2023
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265. Supplemental Figure 5 from In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments

Author

Morris, Zachary S., primary, Guy, Emily I., primary, Francis, David M., primary, Gressett, Monica M., primary, Werner, Lauryn R., primary, Carmichael, Lakeesha L., primary, Yang, Richard K., primary, Armstrong, Eric A., primary, Huang, Shyhmin, primary, Navid, Fariba, primary, Gillies, Stephen D., primary, Korman, Alan, primary, Hank, Jacquelyn A., primary, Rakhmilevich, Alexander L., primary, Harari, Paul M., primary, and Sondel, Paul M., primary

Published
2023
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266. Supplemental Figure 3 from In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments

Author

Morris, Zachary S., primary, Guy, Emily I., primary, Francis, David M., primary, Gressett, Monica M., primary, Werner, Lauryn R., primary, Carmichael, Lakeesha L., primary, Yang, Richard K., primary, Armstrong, Eric A., primary, Huang, Shyhmin, primary, Navid, Fariba, primary, Gillies, Stephen D., primary, Korman, Alan, primary, Hank, Jacquelyn A., primary, Rakhmilevich, Alexander L., primary, Harari, Paul M., primary, and Sondel, Paul M., primary

Published
2023
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267. Supplemental Figure Legends from In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments

Author

Morris, Zachary S., primary, Guy, Emily I., primary, Francis, David M., primary, Gressett, Monica M., primary, Werner, Lauryn R., primary, Carmichael, Lakeesha L., primary, Yang, Richard K., primary, Armstrong, Eric A., primary, Huang, Shyhmin, primary, Navid, Fariba, primary, Gillies, Stephen D., primary, Korman, Alan, primary, Hank, Jacquelyn A., primary, Rakhmilevich, Alexander L., primary, Harari, Paul M., primary, and Sondel, Paul M., primary

Published
2023
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268. Supplemental Figure 4 from In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments

Author

Morris, Zachary S., primary, Guy, Emily I., primary, Francis, David M., primary, Gressett, Monica M., primary, Werner, Lauryn R., primary, Carmichael, Lakeesha L., primary, Yang, Richard K., primary, Armstrong, Eric A., primary, Huang, Shyhmin, primary, Navid, Fariba, primary, Gillies, Stephen D., primary, Korman, Alan, primary, Hank, Jacquelyn A., primary, Rakhmilevich, Alexander L., primary, Harari, Paul M., primary, and Sondel, Paul M., primary

Published
2023
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269. Supplemental Figure 1 from In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments

Author

Morris, Zachary S., primary, Guy, Emily I., primary, Francis, David M., primary, Gressett, Monica M., primary, Werner, Lauryn R., primary, Carmichael, Lakeesha L., primary, Yang, Richard K., primary, Armstrong, Eric A., primary, Huang, Shyhmin, primary, Navid, Fariba, primary, Gillies, Stephen D., primary, Korman, Alan, primary, Hank, Jacquelyn A., primary, Rakhmilevich, Alexander L., primary, Harari, Paul M., primary, and Sondel, Paul M., primary

Published
2023
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270. Supplemental Figure 2 from In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments

Author

Morris, Zachary S., primary, Guy, Emily I., primary, Francis, David M., primary, Gressett, Monica M., primary, Werner, Lauryn R., primary, Carmichael, Lakeesha L., primary, Yang, Richard K., primary, Armstrong, Eric A., primary, Huang, Shyhmin, primary, Navid, Fariba, primary, Gillies, Stephen D., primary, Korman, Alan, primary, Hank, Jacquelyn A., primary, Rakhmilevich, Alexander L., primary, Harari, Paul M., primary, and Sondel, Paul M., primary

Published
2023
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271. Data from In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments

Author

Morris, Zachary S., primary, Guy, Emily I., primary, Francis, David M., primary, Gressett, Monica M., primary, Werner, Lauryn R., primary, Carmichael, Lakeesha L., primary, Yang, Richard K., primary, Armstrong, Eric A., primary, Huang, Shyhmin, primary, Navid, Fariba, primary, Gillies, Stephen D., primary, Korman, Alan, primary, Hank, Jacquelyn A., primary, Rakhmilevich, Alexander L., primary, Harari, Paul M., primary, and Sondel, Paul M., primary

Published
2023
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272. Megastudy identifying effective interventions to strengthen Americans’ democratic attitudes

Author

Voelkel, Jan G., primary, Stagnaro, Michael, additional, Chu, James, additional, Pink, Sophia Lerner, additional, Mernyk, Joseph S., additional, Redekopp, Chrystal, additional, Ghezae, Isaias, additional, Cashman, Matthew, additional, Adjodah, Dhaval, additional, Allen, Levi, additional, Allis, Victor, additional, Baleria, Gina, additional, Ballantyne, Nathan, additional, Van Bavel, Jay Joseph, additional, Blunden, Hayley, additional, Braley, Alia, additional, Bryan, Christopher, additional, Celniker, Jared, additional, Cikara, Mina, additional, Clapper, Margarett, additional, Clayton, Katherine, additional, Collins, Hanne K., additional, DeFilippis, Evan, additional, DIEFFENBACH, MACRINA, additional, Doell, Kimberly C, additional, Dorison, Charles, additional, Duong, Mylien, additional, Felsman, Peter, additional, Fiorella, Maya, additional, Francis, David, additional, Franz, Michael M., additional, Gallardo, Roman, additional, Gifford, Sara, additional, Goya-Tocchetto, Daniela, additional, Gray, Kurt, additional, Green, Joe, additional, Greene, Joshua D., additional, Güngör, Mertcan, additional, Hall, Matthew, additional, Hecht, Cameron, additional, Javeed, Ali, additional, Jost, John, additional, Kay, Aaron, additional, Kay, Nicholas, additional, Keating, Brandyn, additional, Kelly, John Michael, additional, Kirk, James, additional, Kopell, Malka, additional, Kteily, Nour, additional, Kubin, Emily, additional, Lees, Jeffrey Martin, additional, Lenz, Gabriel, additional, Levendusky, Matt, additional, Littman, Rebecca, additional, Luo, Kara, additional, Lyles, Aaron, additional, Lyons, Benjamin, additional, Marsh, Wayde, additional, Martherus, James, additional, Maurer, Lauren Alpert, additional, Mehl, Caroline, additional, minson, julia, additional, Moore, Molly, additional, Moore-Berg, Samantha, additional, Pasek, Michael H., additional, Pentland, Alex, additional, Puryear, Curtis, additional, Rahnama, Hossein, additional, Rathje, Steve, additional, Rosato, Jay, additional, Saar-Tsechansky, Maytal, additional, Santos, Luiza, additional, Seifert, Colleen, additional, Shariff, Azim, additional, Simonsson, Otto, additional, Spitz Siddiqi, Shiri, additional, Stone, Daniel, additional, Strand, Palma, additional, Tomz, Michael, additional, Yeager, David Scott, additional, Yoeli, Erez, additional, zaki, jamil, additional, Druckman, James, additional, Rand, David Gertler, additional, and Willer, Robb, additional

Published
2023
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273. WWOX developmental and epileptic encephalopathy: Understanding the epileptology and the mortality risk

Author

Oliver, Karen L., primary, Trivisano, Marina, additional, Mandelstam, Simone A., additional, De Dominicis, Angela, additional, Francis, David I., additional, Green, Timothy E., additional, Muir, Alison M., additional, Chowdhary, Apoorva, additional, Hertzberg, Christoph, additional, Goldhahn, Klaus, additional, Metreau, Julia, additional, Prager, Christine, additional, Pinner, Jason, additional, Cardamone, Michael, additional, Myers, Kenneth A., additional, Leventer, Richard J., additional, Lesca, Gaetan, additional, Bahlo, Melanie, additional, Hildebrand, Michael S., additional, Mefford, Heather C., additional, Kaindl, Angela M., additional, Specchio, Nicola, additional, and Scheffer, Ingrid E., additional

Published
2023
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282. Gating Pore Currents in DIIS4 Mutations of NaV1.4 Associated with Periodic Paralysis: Saturation of Ion Flux and Implications for Disease Pathogenesis

Author

Struyk, Arie F, Markin, Vladislav S, Francis, David, and Cannon, Stephen C

Subjects
Neurosciences, Aetiology, 2.1 Biological and endogenous factors, Amino Acid Substitution, Animals, Arginine, Binding Sites, Electric Conductivity, Hypokalemic Periodic Paralysis, Ion Channel Gating, Ion Transport, Membrane Potentials, Models, Molecular, Muscle Proteins, Muscle, Skeletal, Mutant Proteins, Patch-Clamp Techniques, Potassium, Protons, Rats, Sodium, Sodium Channels, Physiology, Medical Physiology
Abstract

S4 voltage-sensor mutations in CaV1.1 and NaV1.4 channels cause the human muscle disorder hypokalemic periodic paralysis (HypoPP). The mechanism whereby these mutations predispose affected sarcolemma to attacks of sustained depolarization and loss of excitability is poorly understood. Recently, three HypoPP mutations in the domain II S4 segment of NaV1.4 were shown to create accessory ionic permeation pathways, presumably extending through the aqueous gating pore in which the S4 segment resides. However, there are several disparities between reported gating pore currents from different investigators, including differences in ionic selectivity and estimates of current amplitude, which in turn have important implications for the pathological relevance of these aberrant currents. To clarify the features of gating pore currents arising from different DIIS4 mutants, we recorded gating pore currents created by HypoPP missense mutations at position R666 in the rat isoform of Nav1.4 (the second arginine from the outside, at R672 in human NaV1.4). Extensive measurements were made for the index mutation, R666G, which created a gating pore that was permeable to K(+) and Na(+). This current had a markedly shallow slope conductance at hyperpolarized voltages and robust inward rectification, even when the ionic gradient strongly favored outward ionic flow. These characteristics were accounted for by a barrier model incorporating a voltage-gated permeation pathway with a single cation binding site oriented near the external surface of the electrical field. The amplitude of the R666G gating pore current was similar to the amplitude of a previously described proton-selective current flowing through the gating pore in rNaV1.4-R663H mutant channels. Currents with similar amplitude and cation selectivity were also observed in R666S and R666C mutant channels, while a proton-selective current was observed in R666H mutant channels. These results add support to the notion that HypoPP mutations share a common biophysical profile comprised of a low-amplitude inward current at the resting potential that may contribute to the pathological depolarization during attacks of weakness.

Published
2008

289. Using Virtual Reality Equipment to Enhance Learning in Extension Youth Programming

Author

Davis, Elizabeth, Ward, Callie, and Francis, David

Abstract

This article provides information on how to use virtual reality equipment to increase participant engagement as well as suggestions for incorporating virtual reality activities into Extension youth programming. These are lessons learned through the use of virtual reality by Extension faculty. Virtual reality equipment can increase participant engagement and improve learning.

Published
2020

290. Intellectual functioning and behavioural features associated with mosaicism in fragile X syndrome

Author

Baker, Emma K., Arpone, Marta, Vera, Solange Aliaga, Bretherton, Lesley, Ure, Alexandra, Kraan, Claudine M., Bui, Minh, Ling, Ling, Francis, David, Hunter, Matthew F., Elliott, Justine, Rogers, Carolyn, Field, Michael J., Cohen, Jonathan, Maria, Lorena Santa, Faundes, Victor, Curotto, Bianca, Morales, Paulina, Trigo, Cesar, Salas, Isabel, Alliende, Angelica M., Amor, David J., and Godler, David E.

Published
2019
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292. The Function and Meaning of Megalithic Cultural Heritage in Some Sites in Bantaeng Regency, South Sulawesi

Author

Rosmawati Rosmawati, Akin Duli, Muhammad Nur, Yusriana Yusriana, Erwin Mansyur Ugu Saraka, Khadijah Thahir Muda, null Stephen Chia, null Yunus Sauman Sabin, null Zuliskandar Ramli, null Francis David Bulbeck, and null Adam Brumm

Subjects
General Medicine
Abstract

The Bantaeng megalithic site houses megalithic cultural relics, such as terraces (teras berundak), dakon, lumpang batu, menhir, dolmen, stone altars, circular stone (batu temu gelang), tombs, and fences, including fragments of pottery and foreign ceramics on the surface of the site. In addition, residents on the site also preserves and performs traditional megalithic rituals. This study aims to find out the functions and meanings of these megalithic cultural relics using surveys, inventory studies, and interviews to the local community. The results indicate that the megalithic culture functions both as a sacred medium of ritual, and a secular instrument of daily life. Furthermore, some of the elements of megalithic culture have symbolic meaning which are related to social status, cosmic symbols, agriculture, astrology, and religious symbols.

Published
2022

294. The Exceptionality of Twice-Exceptionality: Examining Combined Prevalence of Giftedness and Disability Using Multivariate Statistical Simulation.

Author

Cheek, Connor L., Garcia, Jessica L., Mehta, Paras D., Francis, David J., and Grigorenko, Elena L.

Subjects
GIFTED children, DISTRIBUTION (Probability theory), DISABILITIES, LEXICON
Abstract

Twice-exceptionality (2e), broadly defined as the co-occurrence of a gift or talent and a disability, has been a part of the educational lexicon since the 1990s, although its empirical backing is limited. We conducted a comprehensive review of the empirical literature on 2e and created a simulation study of 2e. For the latter, we constructed population distribution functions that represent indicators of ability using a range of correlations and identification criteria guided by the reviewed literature. We observed the theoretical occurrence of 2e, even at its most relaxed definitions, to be much rarer than prevailing literature implies (probability = 0.148). As correlations and factor loadings increase, the prevalence estimates of 2e drop considerably. Our results demonstrated the need for a more informed, standardized, and quantifiable approach to the identification of individuals with 2e. [ABSTRACT FROM AUTHOR]

Published
2023
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296. Impact of Serial Intralesional Steroid Injections on Idiopathic Subglottic Stenosis.

Author

Hoffman, Matthew R., Patro, Ankita, Huang, Li‐Ching, Chen, Sheau‐Chiann, Berry, Lynn D., Gelbard, Alexander, Francis, David O., Anderson, Catherine, Amin, Milan R., Benninger, Michael S., Blumin, Joel H., Bock, Jonathan M., Bryson, Paul C., Castellanos, Paul F., Clary, Matthew S., Cohen, Seth M., Crawley, Brianna K., Dailey, Seth H., Daniero, James J., and de Alarcon, Alessandro

Abstract

Objectives: Serial intralesional steroid injection (SILSI) has been increasingly used to treat idiopathic subglottic stenosis (iSGS). Prior studies have shown effectiveness, but not in all patients. This multi‐institutional study evaluates the effect of SILSI on time to recurrent operation, peak expiratory flow (PEF), and dyspnea. Methods: Post‐hoc secondary analysis of the North American Airway Collaborative data were performed to evaluate the outcomes of iSGS patients undergoing and not undergoing SILSI. The primary outcome was time to recurrent operation, evaluated using Kaplan–Meier curves and Cox regression analysis. Secondary outcomes were change in PEF and clinical chronic obstructive pulmonary disease questionnaire (CCQ) score. Within patients undergoing SILSI, demographics, time from last procedure, and PEF at initiation of SILSI were evaluated to determine the effect on recurrence. Results: Two hundred and ninety patients were included, 238 undergoing endoscopic dilation alone and 52 undergoing dilation and SILSI. No differences in baseline characteristics were observed. There was no difference in time to recurrence (hazard ratio: 0.64; p = 0.183). There were no differences in PEF or CCQ across the 2.5‐year study period. Among 52 patients undergoing SILSI, PEF at the time of starting SILSI did not affect recurrence (χ2 = 0.09, p = 0.77). Conclusion: Patients undergoing and not undergoing SILSI had similar times to recurrence, PEF, and CCQ. Factors predicting recurrence among patients undergoing SILSI were not identified. These results support a randomized controlled trial with a uniform SILSI protocol to quantify the effects of SILSI on objective and subjective outcomes and help determine which iSGS patients benefit most. Level of Evidence: 3 Laryngoscope, 133:2255–2263, 2023 [ABSTRACT FROM AUTHOR]

Published
2023
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297. Baroque musical offerings.

Author

Francis, David

Subjects
*VIOLIN, *MUSICAL composition, *VIOLA da gamba, *DANCE, *HARPSICHORD, *MUSICALS, *TUNING (Musical instruments)
Abstract

This article provides an overview of several recordings of Baroque music. It includes Antonio Vivaldi's "Le Quattro Stagioni" performed by Apollo's Fire, J.S. Bach's lost trio sonatas reconstructed by NeoBarock, Mauro D'Alay's violin concertos performed by Reale Concerto, solo violin pieces from the Klagenfurt manuscript performed by Peter Sheppard Skærved, French flageolet music performed by La Simphonie du Marais, and a compilation of Vivaldi's works performed by Ensemble Toulouse. [Extracted from the article]

Published
2023
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