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Background: Carrier detection before or at early pregnancy through a wide screening program may be a practical approach to prevent the fragile X syndrome. However, prior to implementation of such a program, the carrier prevalence in a population and availability of effective screening tests should be evaluated., Methods: One thousand and two pregnant women were randomly selected from our obstetric clinic and screened for FMRI mutation. Each woman was examined individually using a simple non-radioactive PCR, as well as in pool with two other women using high-resolution Southern blot hybridization., Results: One third of women could be excluded from carrier status by PCR alone, while the rest had to be screened using Southern-blot hybridization in pool with two other women. This screening strategy was reliable and efficient, and suitable for large-scale screening. Among the 1002 women, no carrier of either premutation or full mutation was found. Allele with intermediate CGG-repeat between 40 and 52 was found in only 22 women (2.2%)., Conclusions: Estimation of female fragile X carrier rate in Taiwan could not be made in the present study, due to insufficient sample size. However, the results indicated clearly that the rate in Taiwan was significantly lower than that of Israel (0/1002 vs. 1/113, p = 0.003), and also lower than those from other western counties (1/186-259, p = 0.020-0.049). We doubt that the cost-efficiency of such a wide screening program in Taiwan is acceptable. However, the effective screening strategy proposed in this study would be very helpful for women with family history of mental deficiency of undetermined etiology.

Background: The posterior lumbar interbody fusion (PLIF) procedure allows restoration of the weight-bearing capacity to a more physiological ventral position and maintenance of disc space height. However, the procedure can be technically difficult and may cause complications. It has always been performed bilaterally with paired cages; a single central cage has not been commonly used., Methods: Twenty-eight patients who met the interbody fusion criteria from March 1999 through November 2001 were included in the study. Surgery was performed from the posterior with a single central cage supplemented with transpedicle screws. The follow-up period ranged from 8 to 39 months with a mean of 14.4 months. Clinical outcomes were assessed. Dynamic radiography for fusion mass was interpreted by an independent radiologist., Results: Overall, 92.86% of the patients were satisfied with their conditions after surgery. Radiography study showed the rate of bony fusion being 82.14%. Fibrous union was noted in five patients. No migration of the cage was observed. One patient experienced laceration of the dura without clinical sequelae. One patient had transient paresthesia and recovered within 2 weeks. One patient had transient bladder atony and recovered within 3 days. Overall, the complications were negligible and none of the patients sustained a motor deficit and permanent complication., Conclusions: The PLIF procedure using a single, central cage combined with bilateral pedicle screws fixation obtained satisfactory outcome within a short-term or long-term follow-up period. Since the implant-related complications have seldom been observed, it may be used as an alternative option for recurrent lumbar disc herniation or low grade spondylolisthesis with apparent degenerative disc disease.

A 16-year-old girl underwent emergency laparoscopic surgery for what was thought to be hematoperitoneum secondary to extrauterine pregnancy. During the operation, omental pregnancy was diagnosed and treated by laparoscopy. According to Studiford's criterion, this case can be classified as a primary omental pregnancy. When performing laparoscopy for suspected tubal pregnancy with no visible pathologic changes on either tube, careful evaluation of the whole abdominal cavity is necessary so as not to overlook an abdominal pregnancy.