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251. The immune marker soluble urokinase plasminogen activator receptor is associated with new-onset diabetes in non-smoking women and men

Author

Haugaard, S B, Andersen, O, Hansen, T W, Eugen-Olsen, Jesper, Linneberg, Allan René, Madsbad, Sten, Olsen, M H, Jørgensen, T, Borch-Johnsen, Knut, and Jeppesen, J

Subjects
Adult, Male, Age Factors, Middle Aged, Prognosis, Risk Assessment, Receptors, Urokinase Plasminogen Activator, Cohort Studies, Sex Factors, Diabetes Mellitus, Type 2, Risk Factors, Humans, Biological Markers, Female, Inflammation Mediators, Aged, Follow-Up Studies
Abstract

To explore the putative association of new-onset diabetes and the soluble urokinase plasminogen activator receptor (suPAR), which is a new and stable plasma marker of immune function and low-grade inflammation. This association has been previously suggested by using the less sensitive International Classification of Disease system to detect incident diabetes in the Danish MONICA 10 cohort.

Published
2012

253. Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution (Nature Genetics (2010) 42 (949-960))

Author

Heid, IM, Jackson, AU, Randall, JC, Winkler, TW, Qi, L, Steinthorsdottir, V, Thorleifsson, G, Zillikens, MC, Speliotes, EK, Mägi, R, Workalemahu, T, White, CC, Bouatia-Naji, N, Harris, TB, Berndt, SI, Ingelsson, E, Willer, CJ, Weedon, MN, Luan, J, Vedantam, S, Esko, T, Kilpeläinen, TO, Kutalik, Z, Li, S, Monda, KL, Dixon, AL, Holmes, CC, Kaplan, LM, Liang, L, Min, JL, Moffatt, MF, Molony, C, Nicholson, G, Schadt, EE, Zondervan, KT, Feitosa, MF, Ferreira, T, Allen, HL, Weyant, RJ, Wheeler, E, Wood, AR, Estrada, K, Goddard, ME, Lettre, G, Mangino, M, Nyholt, DR, Purcell, S, Vernon Smith, A, Visscher, PM, Yang, J, McCarroll, SA, Nemesh, J, Voight, BF, Absher, D, Amin, N, Aspelund, T, Coin, L, Glazer, NL, Hayward, C, Heard-Costa, NL, Hottenga, J-J, Johansson, A, Johnson, T, Kaakinen, M, Kapur, K, Ketkar, S, Knowles, JW, Kraft, P, Kraja, AT, Lamina, C, Leitzmann, MF, McKnight, B, Morris, AP, Ong, KK, Perry, JRB, Peters, MJ, Polasek, O, Prokopenko, I, Rayner, NW, Ripatti, S, Rivadeneira, F, Robertson, NR, Sanna, S, Sovio, U, Surakka, I, Teumer, A, Van Wingerden, S, Vitart, V, Zhao, JH, Cavalcanti-Proença, C, Chines, PS, Fisher, E, Kulzer, JR, Lecoeur, C, Narisu, N, Sandholt, C, Scott, LJ, Silander, K, Stark, K, Tammesoo, M-L, Teslovich, TM, Timpson, NJ, Watanabe, RM, Welch, R, Chasman, DI, Cooper, MN, Jansson, J-O, Kettunen, J, Lawrence, RW, Pellikka, N, Perola, M, Vandenput, L, Alavere, H, Almgren, P, Atwood, LD, Bennett, AJ, Biffar, R, Bonnycastle, LL, Bornstein, SR, Buchanan, TA, Campbell, H, Day, INM, Dei, M, Dörr, M, Elliott, P, Erdos, MR, Eriksson, JG, Freimer, NB, Fu, M, Gaget, S, Geus, EJC, Gjesing, AP, Grallert, H, Gräßler, J, Groves, CJ, Guiducci, C, Hartikainen, A-L, Hassanali, N, Havulinna, AS, Herzig, K-H, Hicks, AA, Hui, J, Igl, W, Jousilahti, P, Jula, A, Kajantie, E, Kinnunen, L, Kolcic, I, Koskinen, S, Kovacs, P, Kroemer, HK, Krzelj, V, Kuusisto, J, Kvaloy, K, Laitinen, J, Lantieri, O, Lathrop, GM, Lokki, M-L, Luben, RN, Ludwig, B, McArdle, WL, McCarthy, A, Morken, MA, Nelis, M, Neville, MJ, Paré, G, Parker, AN, Peden, JF, Pichler, I, Pietiläinen, KH, Platou, CGP, Pouta, A, Ridderstråle, M, Samani, NJ, Saramies, J, Sinisalo, J, Smit, JH, Strawbridge, RJ, Stringham, HM, Swift, AJ, Teder-Laving, M, Thomson, B, Usala, G, Van Meurs, JBJ, Van Ommen, G-J, Vatin, V, Volpato, CB, Wallaschofski, H, Walters, GB, Widen, E, Wild, SH, Willemsen, G, Witte, DR, Zgaga, L, Zitting, P, Beilby, JP, James, AL, Kähönen, M, Lehtimäki, T, Nieminen, MS, Ohlsson, C, Palmer, LJ, Raitakari, O, Ridker, PM, Stumvoll, M, Tönjes, A, Viikari, J, Balkau, B, Ben-Shlomo, Y, Bergman, RN, Boeing, H, Smith, GD, Ebrahim, S, Froguel, P, Hansen, T, Hengstenberg, C, Hveem, K, Isomaa, B, Jørgensen, T, Karpe, F, Khaw, K-T, Laakso, M, Lawlor, DA, Marre, M, Meitinger, T, Metspalu, A, Midthjell, K, Pedersen, O, Salomaa, V, Schwarz, PEH, Tuomi, T, Tuomilehto, J, Valle, TT, Wareham, NJ, Arnold, AM, Beckmann, JS, Bergmann, S, Boerwinkle, E, Boomsma, DI, Caulfield, MJ, Collins, FS, Eiriksdottir, G, Gudnason, V, Gyllensten, U, Hamsten, A, Hattersley, AT, Hofman, A, Hu, FB, Illig, T, Iribarren, C, Jarvelin, M-R, Kao, WHL, Kaprio, J, Launer, LJ, Munroe, PB, Oostra, B, Penninx, BW, Pramstaller, PP, Psaty, BM, Quertermous, T, Rissanen, A, Rudan, I, Shuldiner, AR, Soranzo, N, Spector, TD, Syvanen, A-C, Uda, M, Uitterlinden, A, Völzke, H, Vollenweider, P, Wilson, JF, Witteman, JC, Wright, AF, Abecasis, GR, Boehnke, M, Borecki, IB, Deloukas, P, Frayling, TM, Groop, LC, Haritunians, T, Hunter, DJ, Kaplan, RC, North, KE, O'Connell, JR, Peltonen, L, Schlessinger, D, Strachan, DP, Hirschhorn, JN, Assimes, TL, Wichmann, H-E, Thorsteinsdottir, U, Van Duijn, CM, Stefansson, K, Cupples, LA, Loos, RJF, Barroso, I, McCarthy, MI, Fox, CS, Mohlke, KL, and Lindgren, CM

Published
2011

255. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Author

Strawbridge, Rj, Dupuis, J, Prokopenko, I, Barker, A, Ahlqvist, E, Rybin, D, Petrie, Jr, Travers, Me, Bouatia Naji, N, Dimas, As, Nica, A, Wheeler, E, Chen, H, Voight, Bf, Taneera, J, Kanoni, S, Peden, Jf, Turrini, F, Gustafsson, S, Zabena, C, Almgren, P, Barker, Dj, Barnes, D, Dennison, Em, Eriksson, Jg, Eriksson, P, Eury, E, Folkersen, L, Fox, Cs, Frayling, Tm, Goel, A, Gu, Hf, Horikoshi, M, Isomaa, B, Jackson, Au, Jameson, Ka, Kajantie, E, Kerr Conte, J, Kuulasmaa, T, Kuusisto, J, Loos, Rj, Luan, J, Makrilakis, K, Manning, Ak, Martínez Larrad MT, Narisu, N, Nastase Mannila, M, Ohrvik, J, Osmond, C, Pascoe, L, Payne, F, Sayer, Aa, Sennblad, B, Silveira, A, Stancáková, A, Stirrups, K, Swift, Aj, Syvänen, Ac, Tuomi, T, van 't Hooft FM, Walker, M, Weedon, Mn, Xie, W, Zethelius, B, Diagram, Consortium, Giant, Consortium, Muther, Consortium, Cardiogram, Consortium, C4d, Consortium, Ongen, H, Mälarstig, A, Hopewell, Jc, Saleheen, D, Chambers, J, Parish, S, Danesh, J, Kooner, J, Ostenson, Cg, Lind, L, Cooper, Cc, Serrano Ríos, M, Ferrannini, E, Forsen, Tj, Clarke, R, Franzosi, Mg, Seedorf, U, Watkins, H, Froguel, P, Johnson, P, Deloukas, P, Collins, Fs, Laakso, M, Dermitzakis, Et, Boehnke, M, Mccarthy, Mi, Wareham, Nj, Groop, L, Pattou, F, Gloyn, Al, Dedoussis, Gv, Lyssenko, V, Meigs, Jb, Barroso, I, Watanabe, Rm, Ingelsson, E, Langenberg, C, Hamsten, A, Voight BF, Florez J. C., Scott, Lj, Steinthorsdottir, V, Morris, Ap, Dina, C, Welch, Rp, Zeggini, E, Huth, C, Aulchenko, Ys, Thorleifsson, G, Mcculloch, Lj, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, Cj, Raychaudhuri, S, Mccarroll, Sa, Hofmann, Om, Qi, L, Segrè, Av, van Hoek, M, Navarro, P, Ardlie, K, Balkau, B, Benediktsson, R, Bennett, Aj, Blagieva, R, Boerwinkle, E, Bonnycastle, Ll, Bengtsson Boström, K, Bravenboer, B, Bumpstead, S, Burtt, P, Charpentier, G, Chines, Ps, Cornelis, M, Couper, Dj, Crawford, G, Doney, As, Elliott, Ks, Elliott, Al, Erdos, Mr, Franklin, Cs, Gieger, C, Grarup, N, Green, T, Griffin, S, Groves, Cj, Guiducci, C, Hadjadj, S, Hassanali, N, Herder, C, Johnson, Pr, Jørgensen, T, Kao, Wh, Klopp, N, Kong, A, Kraft, P, Lauritzen, T, Li, M, Lieverse, A, Lindgren, Cm, Marre, M, Meitinger, T, Midthjell, K, Morken, Ma, Nilsson, P, Owen, Kr, Perry, Jr, Petersen, K, Platou, C, Proença, C, Rathmann, W, William Rayner, N, Robertson, Nr, Rocheleau, G, Roden, M, Sampson, Mj, Saxena, R, Shields, Bm, Shrader, P, Sigurdsson, G, Sparsø, T, Strassburger, K, Stringham, Hm, Sun, Q, Thorand, B, Tichet, J, van Dam RM, van Haeften TW, van Herpt, T, van Vliet JV, Bragi Walters, G, Wijmenga, C, Witteman, J, Bergman, Rn, Cauchi, S, Gyllensten, U, Hansen, T, Hide, Wa, Hitman, Ga, Hofman, A, Hunter, Dj, Hveem, K, Mohlke, Kl, Morris, Ad, Palmer, Cn, Pramstaller, Pp, Rudan, I, Sijbrands, E, Stein, Ld, Tuomilehto, J, Uitterlinden, A, Abecasis, Gr, Boehm, Bo, Campbell, H, Daly, Mj, Hattersley, At, Hu, Fb, Pankow, Js, Pedersen, O, Wichmann, E, Florez, Jc, Sladek, R, Thorsteinsdottir, U, Wilson, Jf, Illig, T, Stefansson, K, Altshuler, D, Speliotes, Ek, Berndt, Si, Monda, Kl, Allen, Hl, Mägi, R, Randall, Jc, Vedantam, S, Winkler, Tw, Workalemahu, T, Heid, Im, Wood, Ar, Weyant, Rj, Estrada, K, Liang, L, Nemesh, J, Park, Jh, Kilpeläinen, To, Yang, J, Esko, T, Feitosa, Mf, Kutalik, Z, Mangino, M, Scherag, A, Smith, Av, Welch, R, Zhao, Jh, Aben, Kk, Absher, Dm, Dixon, Al, Fisher, E, Glazer, Nl, Goddard, Me, Heard Costa NL, Hoesel, V, Hottenga, Jj, Johansson, Å, Johnson, T, Ketkar, S, Lamina, C, Li, S, Moffatt, Mf, Myers, Rh, Peters, Mj, Preuss, M, Ripatti, S, Rivadeneira, F, Sandholt, C, Timpson, Nj, Tyrer, Jp, van Wingerden, S, White, Cc, Wiklund, F, Barlassina, C, Chasman, Di, Cooper, Mn, Jansson, Jo, Lawrence, Rw, Pellikka, N, Shi, J, Thiering, E, Alavere, H, Alibrandi, Mt, Arnold, Am, Aspelund, T, Atwood, Ld, Balmforth, Aj, Ben Shlomo, Y, Bergmann, S, Biebermann, H, Blakemore, Ai, Boes, T, Bornstein, Sr, Brown, Mj, Buchanan, Ta, Busonero, F, Cappuccio, Fp, Cavalcanti Proença, C, Ida Chen YD, Chen, Cm, Coin, L, Connell, J, Day, In, den Heijer, M, Duan, J, Ebrahim, S, Elliott, P, Elosua, R, Eiriksdottir, G, Facheris, Mf, Felix, Sb, Fischer Posovszky, P, Folsom, Ar, Friedrich, N, Freimer, Nb, Fu, M, Gaget, S, Gejman, Pv, Geus, Ej, Gjesing, Ap, Goyette, P, Grässler, J, Greenawalt, Dm, Gudnason, V, Hartikainen, Al, Hall, As, Havulinna, As, Hayward, C, Heath, Ac, Hengstenberg, C, Hicks, Aa, Hinney, A, Homuth, G, Hui, J, Igl, W, Iribarren, C, Jacobs, Kb, Jarick, I, Jewell, E, John, U, Jousilahti, P, Jula, A, Kaakinen, M, Kaplan, Lm, Kathiresan, S, Kettunen, J, Kinnunen, L, Knowles, Jw, Kolcic, I, König, Ir, Koskinen, S, Kovacs, P, Kvaløy, K, Laitinen, J, Lantieri, O, Lanzani, C, Launer, Lj, Lecoeur, C, Terho, L, Lettre, G, Liu, J, Lokki, Ml, Lorentzon, M, Luben, Rn, Ludwig, B, Magic, Manunta, P, Marek, D, Martin, Ng, Mcardle, Wl, Mccarthy, A, Mcknight, B, Melander, O, Meyre, D, Montgomery, Gw, Mulic, R, Ngwa, Js, Nelis, M, Neville, Mj, Nyholt, Dr, O'Donnell, Cj, O'Rahilly, S, Ong, Kk, Oostra, B, Paré, G, Parker, An, Perola, M, Pichler, I, Pietiläinen, Kh, Platou, Cg, Polasek, O, Pouta, A, Rafelt, S, Raitakari, O, Rayner, Nw, Ridderstråle, M, Rief, W, Ruokonen, A, Rzehak, P, Salomaa, V, Sanders, Ar, Sandhu, Ms, Sanna, S, Saramies, J, Savolainen, Mj, Scherag, S, Schipf, S, Schreiber, S, Schunkert, H, Silander, K, Sinisalo, J, Siscovick, Ds, Smit, Jh, Soranzo, N, Sovio, U, Stephens, J, Surakka, I, Tammesoo, Ml, Tardif, Jc, Teder Laving, M, Teslovich, Tm, Thompson, Jr, Thomson, B, Tönjes, A, van Meurs JB, van Ommen GJ, Vatin, V, Viikari, J, Visvikis Siest, S, Vitart, V, Vogel, Ci, Waite, Ll, Wallaschofski, H, Walters, Gb, Widen, E, Wiegand, S, Wild, Sh, Willemsen, G, Witte, Dr, Witteman, Jc, Xu, J, Zhang, Q, Zgaga, L, Ziegler, A, Zitting, P, Beilby, Jp, Farooqi, Is, Hebebrand, J, Huikuri, Hv, James, Al, Kähönen, M, Levinson, Df, Macciardi, F, Nieminen, Ms, Ohlsson, C, Palmer, Lj, Ridker, Pm, Stumvoll, M, Beckmann, Js, Boeing, H, Dorret, I. B., Caulfield, Mj, Chanock, Sj, Cupples, La, Smith, Gd, Erdmann, J, Grönberg, H, Hall, P, Harris, Tb, Hayes, Rb, Heinrich, J, Jarvelin, Mr, Kaprio, J, Karpe, F, Khaw, Kt, Kiemeney, La, Krude, H, Lawlor, Da, Metspalu, A, Munroe, Pb, Ouwehand, Wh, Penninx, Bw, Peters, A, Quertermous, T, Reinehr, T, Rissanen, A, Samani, Nj, Schwarz, Pe, Shuldiner, Ar, Spector, Td, Uda, M, Valle, Tt, Wabitsch, M, Waeber, G, Shaun, P, Eric, E. S., Peter, M. V., Assimes, Tl, Borecki, Ib, Groop, Lc, Haritunians, T, Kaplan, Rc, O'Connell, Jr, Peltonen, L, Schlessinger, D, Strachan, Dp, van Duijn CM, Barroso, H, North, Ke, Hirschhorn, Jn, Nica, Ac, Parts, L, Glass, D, Nisbet, J, Barrett, A, Sekowska, M, Travers, M, Potter, S, Grundberg, E, Small, K, Hedman, Åk, Bataille, V, Bell, Jt, Surdulescu, G, Ingle, C, Nestle, Fo, di Meglio, P, Min, Jl, Wilk, A, Hammond, Cj, Yang, Tp, Montgomery, Sb, Zondervan, Kt, Durbin, R, Ahmadi, K, Reilly, Mp, Holm, H, Stewart, Af, Barbalic, M, Absher, D, Aherrahrou, Z, Allayee, H, Anand, Ss, Andersen, K, Anderson, Jl, Ardissino, D, Ball, Sg, Barnes, Ta, Becker, Dm, Becker, Lc, Berger, K, Bis, Jc, Boekholdt, Sm, Braund, Ps, Burnett, Ms, Buysschaert, I, Cardiogenics, Carlquist, Jf, Chen, L, Cichon, S, Codd, V, Davies, Rw, Dedoussis, G, Dehghan, A, Demissie, S, Devaney, Jm, Diemert, P, Do, R, Doering, A, Eifert, S, El Mokhtari NE, Ellis, Sg, Engert, Jc, Epstein, Se, de Faire, U, Fischer, M, Freyer, J, Gigante, B, Girelli, Domenico, Gretarsdottir, S, Gulcher, Jr, Halperin, E, Hammond, N, Hazen, Sl, Horne, Bd, Jones, Gt, Jukema, Jw, Kaiser, Ma, Kastelein, Jj, Kolovou, G, Laaksonen, R, Lambrechts, D, Leander, K, Lieb, W, Loley, C, Lotery, Aj, Mannucci, Pm, Maouche, S, Martinelli, Nicola, Mckeown, Pp, Meisinger, C, Merlini, Pa, Mooser, V, Morgan, T, Mühleisen, Tw, Muhlestein, Jb, Münzel, T, Musunuru, K, Nahrstaedt, J, Nelson, Cp, Nöthen, Mm, Olivieri, Oliviero, Patel, Rs, Patterson, Cc, Peyvandi, F, Qu, L, Quyyumi, Aa, Rader, Dj, Rallidis, Ls, Rice, C, Rosendaal, Fr, Rubin, D, Sampietro, Ml, Schadt, E, Schäfer, A, Schillert, A, Schrezenmeir, J, Schwartz, Sm, Sivananthan, M, Sivapalaratnam, S, Smith, A, Smith, Tb, Snoep, Jd, Spertus, Ja, Stark, K, Stoll, M, Tang, Wh, Tennstedt, S, Thorgeirsson, G, Tomaszewski, M, Uitterlinden, Ag, van Rij AM, Wells, Ga, Wichmann, He, Wild, Ps, Willenborg, C, Wright, Bj, Ye, S, Zeller, T, Cambien, F, Goodall, Ah, März, W, Blankenberg, S, Roberts, R, Mcpherson, R, Nilesh, J. S., Medical Research Council (MRC), Nica, Alexandra, Ongen, Halit, Dermitzakis, Emmanouil, ACS - Amsterdam Cardiovascular Sciences, Cardiology, Vascular Medicine, Biological Psychology, EMGO+ - Lifestyle, Overweight and Diabetes, Scherag, Andre (Beitragende*r), Hinney, Anke (Beitragende*r), Scherag, S. (Beitragende*r), Vogel, C (Beitragende*r), Hebebrand, Johannes (Beitragende*r), University of Groningen, Wheeler, Eleanor [0000-0002-8616-6444], Barnes, Daniel [0000-0002-3781-7570], Luan, Jian'an [0000-0003-3137-6337], Johnson, Kathleen [0000-0002-6823-3252], Danesh, John [0000-0003-1158-6791], Wareham, Nicholas [0000-0003-1422-2993], Barroso, Ines [0000-0001-5800-4520], Langenberg, Claudia [0000-0002-5017-7344], and Apollo - University of Cambridge Repository

Subjects
Male, Netherlands Twin Register (NTR), endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Medizin, Genome-wide association study, Type 2 diabetes, CORONARY HEART-DISEASE, Fasting/blood, 0302 clinical medicine, Insulin, Glucose homeostasis, ddc:576.5, Genome-wide, Diabetes Mellitus, Type 2/blood/genetics/metabolism, CARDIoGRAM Consortium, POPULATION, Proinsulin, RISK, Genetics, 0303 health sciences, INSULIN SENSITIVITY, 11 Medical And Health Sciences, Fasting, Polymorphism, Single Nucleotide/genetics, OBESITY, Female, type 2 diabetes, Life Sciences & Biomedicine, hormones, hormone substitutes, and hormone antagonists, Insulin processing, Adult, medicine.medical_specialty, endocrine system, ENDOCRINOLOGY & METABOLISM, SUSCEPTIBILITY LOCI, Genotype, 030209 endocrinology & metabolism, DIAGRAM Consortium, Biology, C4D Consortium, Polymorphism, Single Nucleotide, Molecular epidemiology [NCEBP 1], 03 medical and health sciences, Insulin resistance, BETA-CELL FUNCTION, SDG 3 - Good Health and Well-being, Internal medicine, GIANT Consortium, Internal Medicine, medicine, Humans, METAANALYSIS, 030304 developmental biology, Science & Technology, Genome, Human, Hormonal regulation [IGMD 6], Genetic Variation, nutritional and metabolic diseases, proinsulin, medicine.disease, Proinsulin/blood, TCF7L2, Endocrinology, Diabetes Mellitus, Type 2, MuTHER Consortium, GLUCOSE-HOMEOSTASIS, Insulin/blood
Abstract

OBJECTIVE Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10−8). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10−4), improved β-cell function (P = 1.1 × 10−5), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10−6). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis.

Published
2011

263. Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116))

Author

Dupuis, J, Langenberg, C, Prokopenko, I, Saxena, R, Soranzo, N, Jackson, AU, Wheeler, E, Glazer, NL, Bouatia-Naji, N, Gloyn, AL, Lindgren, CM, Mägi, R, Morris, AP, Randall, J, Johnson, T, Elliott, P, Rybin, D, Thorleifsson, G, Steinthorsdottir, V, Henneman, P, Grallert, H, Dehghan, A, Hottenga, JJ, Franklin, CS, Navarro, P, Song, K, Goel, A, Perry, JRB, Egan, JM, Lajunen, T, Grarup, N, Sparsø, T, Doney, A, Voight, BF, Stringham, HM, Li, M, Kanoni, S, Shrader, P, Cavalcanti-Proença, C, Kumari, M, Qi, L, Timpson, NJ, Gieger, C, Zabena, C, Rocheleau, G, Ingelsson, E, An, P, O'Connell, J, Luan, J, Elliott, A, McCarroll, SA, Payne, F, Roccasecca, RM, Pattou, F, Sethupathy, P, Ardlie, K, Ariyurek, Y, Balkau, B, Barter, P, Beilby, JP, Ben-Shlomo, Y, Benediktsson, R, Bennett, AJ, Bergmann, S, Bochud, M, Boerwinkle, E, Bonnefond, A, Bonnycastle, LL, Borch-Johnsen, K, Böttcher, Y, Brunner, E, Bumpstead, SJ, Charpentier, G, Chen, Y-DI, Chines, P, Clarke, R, Coin, LJM, Cooper, MN, Cornelis, M, Crawford, G, Crisponi, L, Day, INM, De Geus, EJC, Delplanque, J, Dina, C, Erdos, MR, Fedson, AC, Fischer-Rosinsky, A, Forouhi, NG, Fox, CS, Frants, R, Franzosi, MG, Galan, P, Goodarzi, MO, Graessler, J, Groves, CJ, Grundy, S, Gwilliam, R, Gyllensten, U, Hadjadj, S, Hallmans, G, Hammond, N, Han, X, Hartikainen, A-L, Hassanali, N, Hayward, C, Heath, SC, Hercberg, S, Herder, C, Hicks, AA, Hillman, DR, Hingorani, AD, Hofman, A, Hui, J, Hung, J, Isomaa, B, Johnson, PRV, Jørgensen, T, Jula, A, Kaakinen, M, Kaprio, J, Kesaniemi, YA, Kivimaki, M, Knight, B, Koskinen, S, Kovacs, P, Kyvik, KO, Lathrop, GM, Lawlor, DA, Le Bacquer, O, Lecoeur, C, Li, Y, Lyssenko, V, Mahley, R, Mangino, M, Manning, AK, Martínez-Larrad, MT, McAteer, JB, McCulloch, LJ, McPherson, R, Meisinger, C, Melzer, D, Meyre, D, Mitchell, BD, Morken, MA, Mukherjee, S, Naitza, S, Narisu, N, Neville, MJ, Oostra, BA, Orr, M, Pakyz, R, Palmer, CNA, Paolisso, G, Pattaro, C, Pearson, D, Peden, JF, Pedersen, NL, Perola, M, Pfeiffer, AFH, Pichler, I, Polasek, O, Posthuma, D, Potter, SC, Pouta, A, Province, MA, Psaty, BM, Rathmann, W, Rayner, NW, Rice, K, Ripatti, S, Rivadeneira, F, Roden, M, Rolandsson, O, Sandbaek, A, Sandhu, M, Sanna, S, Sayer, AA, Scheet, P, Scott, LJ, Seedorf, U, Sharp, SJ, Shields, B, Sigursson, G, Sijbrands, EJG, Silveira, A, Simpson, L, Singleton, A, Smith, NL, Sovio, U, Swift, A, Syddall, H, Syvänen, A-C, Tanaka, T, Thorand, B, Tichet, J, Tönjes, A, Tuomi, T, Uitterlinden, AG, Van Dijk, KW, Van Hoek, M, Varma, D, Visvikis-Siest, S, Vitart, V, Vogelzangs, N, Waeber, G, Wagner, PJ, Walley, A, Walters, GB, Ward, KL, Watkins, H, Weedon, MN, Wild, SH, Willemsen, G, Witteman, JCM, Yarnell, JWG, Zeggini, E, Zelenika, D, Zethelius, B, Zhai, G, Zhao, JH, Zillikens, MC, Consortium, D, Consortium, G, Consortium, GB, Borecki, IB, Loos, RJF, Meneton, P, Magnusson, PKE, Nathan, DM, Williams, GH, Hattersley, AT, Silander, K, Salomaa, V, Smith, GD, Bornstein, SR, Schwarz, P, Spranger, J, Karpe, F, Shuldiner, AR, Cooper, C, Dedoussis, GV, Serrano-Ríos, M, Morris, AD, Lind, L, Palmer, LJ, Hu, FB, Franks, PW, Ebrahim, S, Marmot, M, Kao, WHL, Pankow, JS, Sampson, MJ, Kuusisto, J, Laakso, M, Hansen, T, Pedersen, O, Pramstaller, PP, Wichmann, HE, Illig, T, Rudan, I, Wright, AF, Stumvoll, M, Campbell, H, Wilson, JF, Hamsten, A, Bergman, RN, Buchanan, TA, Collins, FS, Mohlke, KL, Tuomilehto, J, Valle, TT, Altshuler, D, Rotter, JI, Siscovick, DS, Penninx, BWJH, Boomsma, DI, Deloukas, P, Spector, TD, Frayling, TM, Ferrucci, L, Kong, A, Thorsteinsdottir, U, Stefansson, K, Van Duijn, CM, Aulchenko, YS, Cao, A, Scuteri, A, Schlessinger, D, Uda, M, Ruokonen, A, Jarvelin, M-R, Waterworth, DM, Vollenweider, P, Peltonen, L, Mooser, V, Abecasis, GR, Wareham, NJ, Sladek, R, Froguel, P, Watanabe, RM, Meigs, JB, Groop, L, Boehnke, M, McCarthy, MI, Florez, JC, and Barroso, I

Published
2010

266. Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies

Author

Thompson, S. Kaptoge, S. White, I. Wood, A. Perry, P. Danesh, J. The Emerging Risk Factors Collaboration Thompson, S.G. Kaptoge, S. White, I.R. Wood, A.M. Perry, P.L. Tipping, R.W. Ford, C.E. Simpson, L.M. Walldius, G. Jungner, I. Chambless, L.E. Panagiotakos, D.B. Pitsavos, C. Chrysohoou, C. Stefanadis, C. Knuiman, M. Goldbourt, U. Benderly, M. Tanne, D. Whincup, P.H. Wannamethee, S.G. Morris, R.W. Willeit, J. Kiechl, S. Santer, P. Mayr, A. Lawlor, D.A. Yarnell, J.W.G. Gallacher, J. Casiglia, E. Tikhonoff, V. Nietert, P.J. Sutherland, S.E. Bachman, D.L. Keil, J.E. Cushman, M. Tracy, R.P. Tybjærg-Hansen, A. Nordestgaard, B.G. Benn, M. Frikke- Schmidt, R. Giampaoli, S. Palmieri, L. Panico, S. Vanuzzo, D. Gómez de la Cámara, A. Gómez- Gerique, J.A. Simons, L. McCallum, J. Friedlander, Y. Fowkes, F.G.R. Lee, A.J. Taylor, J. Guralnik, J.M. Wallace, R. Guralnik, J. Blazer, D.G. Guralnik, J.M. Guralnik, J.M. Khaw, K.-T. Brenner, H. Raum, E. Müller, H. Rothenbacher, D. Jansson, J.H. Wennberg, P. Nissinen, A. Donfrancesco, C. Salomaa, V. Harald, K. Jousilahti, P. Vartiainen, E. Woodward, M. D'Agostino, R.B. Vasan, R.S. Pencina, M.J. Bladbjerg, E.M. Jørgensen, T. Jespersen, J. Møller, L. Dankner, R. Chetrit, A. Lubin, F. Rosengren, A. Lappas, G. Björkelund, C. Lissner, L. Bengtsson, C. Cremer, P. Nagel, D. Tilvis, R.S. Strandberg, T.E. Kiyohara, Y. Arima, H. Doi, Y. Ninomiya, T. Rodriguez, B. Dekker, J.M. Nijpels, G. Stehouwer, C.D.A. Rimm, E. Pai, J.K. Sato, S. Kitamura, A. Iso, H. Goldbourt, U. Noda, H. Harald, K. Jousilahti, P. Vartiainen, E. Salonen, J.T. Tuomainen, T.-P. Deeg, D.J.H. Poppelaars, J.L. Meade, T.W. Cooper, J.A. Hedblad, B. Berglund, G. Engstrom, G. Verschuren, W.M.M. Blokstra, A. Cushman, M. Shea, S. Döring, A. Koenig, W. Meisinger, C. Mraz, W. Bas Bueno-de-Mesquita, H. Kuller, L.H. Grandits, G. Selmer, R. Tverdal, A. Nystad, W. Gillum, R. Mussolino, M. Rimm, E. Manson, J.E. Pai, J.K. Meade, T.W. Cooper, J.A. Cooper, J.A. Knottenbelt, C. Bauer, K.A. Naito, Y. Holme, I. Hankinson, S. Tverdal, A. Nystad, W. Nakagawa, H. Miura, K. Ducimetiere, P. Jouven, X. Crespo, C.J. Garcia Palmieri, M.R. Amouyel, P. Arveiler, D. Evans, A. Ferrieres, J. Schulte, H. Assmann, G. Shepherd, J. Packard, C.J. Sattar, N. Ford, I. Cantin, B. Després, J.-P. Dagenais, G.R. Barrett-Connor, E. Wingard, D.L. Bettencourt, R. Gudnason, V. Aspelund, T. Sigurdsson, G. Thorsson, B. Trevisan, M. Witteman, J. Kardys, I. Breteler, M. Hofman, A. Tunstall-Pedoe, H. Tavendale, R. Lowe, G.D.O. Ben-Shlomo, Y. Howard, B.V. Zhang, Y. Umans, J. Onat, A. Davey-Smith, G. Wilsgaard, T. Ingelsson, E. Lind, L. Giedraitis, V. Lannfelt, L. Gaziano, J.M. Ridker, P. Gaziano, J.M. Ridker, P. Ulmer, H. Diem, G. Concin, H. Tosetto, A. Rodeghiero, F. Wassertheil-Smoller, S. Manson, J.E. Marmot, M. Clarke, R. Collins, R. Brunner, E. Shipley, M. Ridker, P. Buring, J. Shepherd, J. Cobbe, S.M. Robertson, M. He, Y. Marín Ibañez, A. Feskens, E.J.M. Kromhout, D. Collins, R. Di Angelantonio, E. Erqou, S. Kaptoge, S. Lewington, S. Orfei, L. Pennells, L. Perry, P.L. Ray, K.K. Sarwar, N. Alexander, M. Thompson, A. Thompson, S.G. Walker, M. Watson, S. Wensley, F. White, I.R. Wood, A.M.

Abstract

Background Meta-analysis of individual participant time-to-event data from multiple prospective epidemiological studies enables detailed investigation of exposure-risk relationships, but involves a number of analytical challenges. Methods This article describes statistical approaches adopted in the Emerging Risk Factors Collaboration, in which primary data from more than 1 million participants in more than 100 prospective studies have been collated to enable detailed analyses of various risk markers in relation to incident cardiovascular disease outcomes. Results Analyses have been principally based on Cox proportional hazards regression models stratified by sex, undertaken in each study separately. Estimates of exposure-risk relationships, initially unadjusted and then adjusted for several confounders, have been combined over studies using meta-analysis. Methods for assessing the shape of exposure-risk associations and the proportional hazards assumption have been developed. Estimates of interactions have also been combined using meta-analysis, keeping separate within-and between-study information. Regression dilution bias caused by measurement error and within-person variation in exposures and confounders has been addressed through the analysis of repeat measurements to estimate corrected regression coefficients. These methods are exemplified by analysis of plasma fibrinogen and risk of coronary heart disease, and Stata code is made available. Conclusion Increasing numbers of meta-analyses of individual participant data from observational data are being conducted to enhance the statistical power and detail of epidemiological studies. The statistical methods developed here can be used to address the needs of such analyses. © The Author 2010; all rights reserved.

Published
2010

267. Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians

Author

Linneberg, A, Gonzalez-Quintela, A, Vidal, C, Jørgensen, T, Fenger, M, Hansen, Torben, Pedersen, O, and Husemoen, L L N

Subjects
Adult, Adolescent, Ethanol, Genotype, Alcoholic Beverages, Denmark, European Continental Ancestry Group, Acetaldehyde, Aldehyde Dehydrogenase, Middle Aged, Drug Hypersensitivity, Alcoholism, Humans, Genetic Predisposition to Disease, Alleles, Aged
Abstract

Udgivelsesdato: 2010-Jan BACKGROUND: Although hypersensitivity reactions following intake of alcoholic drinks are common in Caucasians, the underlying mechanisms and clinical significance are not known. In contrast, in Asians, alcohol-induced asthma and flushing have been shown to be because of a single nucleotide polymorphism (SNP), the acetaldehyde dehydrogenase 2 (ALDH2) 487lys, causing decreased acetaldehyde (the metabolite of ethanol) metabolism and high levels of histamine. However, the ALDH2 487lys is absent in Caucasians. OBJECTIVES: To investigate the genetic determinants of self-reported alcohol-induced hypersensitivity reactions in Caucasians. METHODS: The study included two population-based studies of 1216 and 6784 adults living in Copenhagen. Assessment of alcohol consumption and hypersensitivity reactions (in a subgroup) was performed by a questionnaire and was related to common SNPs of genes encoding alcohol dehydrogenases (ADHs) and ALDHs. RESULTS: In both populations, alcohol drinkers with a genetically determined fast metabolism of ethanol (the A allele of the ADH1b rs1229984) had an increased risk of alcohol-induced hypersensitivity reactions (odds ratio AA/AG vs. GG in combined populations: 1.82, 95% CI 1.04-3.17). In both populations, a common SNP encoding ALDH1b1 (rs2228093) was found to be significantly associated with alcohol-induced hypersensitivity (odds ratio TT vs. CC in combined populations: 2.53, 95% CI 1.31-4.90). CONCLUSIONS: Our data support that alcohol sensitivity in Caucasians is genetically determined and suggest that a histamine-releasing effect of acetaldehyde represents a plausible biological mechanism. Furthermore, we present the first report of a clinically significant SNP within the acetaldehyde-metabolizing system in a Caucasian population.

Published
2010

274. Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality

Author

Tipping, R.W. Ford, C.E. Simpson, L.M. Walldius, G. Jungner, I. Folsom, A.R. Chambless, L. Panagiotakos, D. Pitsavos, C. Chrysohoou, C. Stefanadis, C. Goldbourt, U. Benderly, M. Tanne, D. Whincup, P. Wannamethee, S.G. Morris, R.W. Kiechl, S. Willeit, J. Santer, P. Mayr, A. Wald, N. Ebrahim, S. Lawlor, D. Yarnell, J. Gallacher, J. Casiglia, E. Tikhonoff, V. Nietert, P.J. Sutherland, S.E. Bachman, D.L. Cushman, M. Psaty, B.M. Tracy, R. Tybjærg-Hansen, A. Nordestgaard, B.G. Frikke-Schmidt, R. Kamstrup, P.R. Giampaoli, S. Palmieri, L. Panico, S. Vanuzzo, D. Pilotto, L. De La Cámara, A.G. Gómez Gerique, J.A. Simons, L. McCallum, J. Friedlander, Y. Fowkes, F.G.R. Lee, A. Smith, F.B. Taylor, J. Guralnik, J.M. Phillips, C.L. Wallace, R.B. Blazer, D.G. Brenner, H. Raum, E. Müller, H. Rothenbacher, D. Jansson, J.-H. Wennberg, P. Nissinen, A. Donfrancesco, C. Salomaa, V. Harald, K. Jousilahti, P. Vartiainen, E. Woodward, M. D’Agostino, R.B. Wolf, P.A. Vasan, R.S. Pencina, M.J. Bladbjerg, E.-M. Jørgensen, T. Møller, L. Jespersen, J. Dankner, R. Chetrit, A. Lubin, F. Rosengren, A. Wilhelmsen, L. Lappas, G. Eriksson, H. Björkelund, C. Lissner, L. Bengtsson, C. Cremer, P. Nagel, D. Tilvis, R.S. Strandberg, T.E. Rodriguez, B. Dekker, J. Nijpels, G. Stehouwer, C.D.A. Rimm, E. Pai, J.K. Sato, S. Iso, H. Kitamura, A. Noda, H. Salonen, J.T. Nyyssönen, K. Tuomainen, T.-P. Deeg, D.J.H. Poppelaars, J.L. Hedblad, B. Berglund, G. Engström, G. Verschuren, W.M.M. Blokstra, A. Döring, A. Koenig, W. Meisinger, C. Mraz, W. Bueno-De-Mesquita, H.B. Kuller, L.H. Grandits, G. Selmer, R. Tverdal, A. Nystad, W. Gillum, R.F. Mussolino, M. Hankinson, S. Manson, J.E. Cooper, J.A. Bauer, K.A. Naito, Y. Holme, I. Nakagawa, H. Miura, K. Ducimetiere, P. Jouven, X. Luc, G. Crespo, C.J. Garcia Palmieri, M.R. Amouyel, P. Arveiler, D. Evans, A. Ferrieres, J. Schulte, H. Assmann, G. Shepherd, J. Packard, C.J. Sattar, N. Ford, I. Cantin, B. Lamarche, B. Després, J.-P. Dagenais, G.R. Barrett-Connor, E. Daniels, L.B. Laughlin, G.A. Gudnason, V. Aspelund, T. Sigurdsson, G. Thorsson, B. Trevisan, M. Witteman, J. Kardys, I. Breteler, M.M.B. Hofman, A. Tunstall-Pedoe, H. Tavendale, R. Lowe, G. Ben-Shlomo, Y. Davey-Smith, G. Howard, B.V. Zhang, Y. Best, L. Umans, J. Onat, A. Njølstad, I. Mathiesen, E.B. Løchen, M.-L. Wilsgaard, T. Ingelsson, E. Sundström, J. Lind, L. Lannfelt, L. Gaziano, J.M. Stampfer, M. Ridker, P.M. Ulmer, H. Diem, G. Concin, H. Tosetto, A. Rodeghiero, F. Marmot, M. Clarke, R. Collins, R. Fletcher, A. Brunner, E. Shipley, M. Buring, J. Cobbe, S. Robertson, M. He, Y. Ibañez, A.M. Feskens, E. Kromhout, D. Walker, M. Watson, S. Di Angelantonio, E. Erqou, S. Kaptoge, S. Lewington, S. Orfei, L. Pennells, L. Perry, P.L. Ray, K.K. Sarwar, N. Alexander, M. Thompson, A. Thompson, S.G. Wensley, F. White, I.R. Wood, A.M. Danesh, J.

Abstract

Context Circulating concentration of lipoprotein(a) (Lp[a]), a large glycoprotein attached to a low-density lipoprotein–like particle, may be associated with risk of coronary heart disease (CHD) and stroke. Objective To assess the relationship of Lp(a) concentration with risk of major vascular and nonvascular outcomes. Study Selection Long-term prospective studies that recorded Lp(a) concentration and subsequent major vascular morbidity and/or cause-specific mortality published between January 1970 and March 2009 were identified through electronic searches of MEDLINE and other databases, manual searches of reference lists, and discussion with collaborators. Data Extraction Individual records were provided for each of 126 634 participants in 36 prospective studies. During 1.3 million person-years of follow-up, 22 076 firstever fatal or nonfatal vascular disease outcomes or nonvascular deaths were recorded, including 9336 CHD outcomes, 1903 ischemic strokes, 338 hemorrhagic strokes, 751 unclassified strokes, 1091 other vascular deaths, 8114 nonvascular deaths, and 242 deaths of unknown cause. Within-study regression analyses were adjusted for within-person variation and combined using meta-analysis. Analyses excluded participants with known preexisting CHD or stroke at baseline. Data Synthesis Lipoprotein(a) concentration was weakly correlated with several conventional vascular risk factors and it was highly consistent within individuals over several years. Associations of Lp(a) with CHD risk were broadly continuous in shape. In the 24 cohort studies, the rates of CHD in the top and bottom thirds of baseline Lp(a) distributions, respectively, were 5.6 (95% confidence interval [CI], 5.4-5.9) per 1000 personyears and 4.4 (95% CI, 4.2-4.6) per 1000 person-years. The risk ratio for CHD, adjusted for age and sex only, was 1.16 (95% CI, 1.11-1.22) per 3.5-fold higher usual Lp(a) concentration (ie, per 1 SD), and it was 1.13 (95% CI, 1.09-1.18) following further adjustment for lipids and other conventional risk factors. The corresponding adjusted risk ratios were 1.10 (95% CI, 1.02-1.18) for ischemic stroke, 1.01 (95% CI, 0.98-1.05) for the aggregate of nonvascular mortality, 1.00 (95% CI, 0.97-1.04) for cancer deaths, and 1.00 (95% CI, 0.95-1.06) for nonvascular deaths other than cancer. Conclusion Under a wide range of circumstances, there are continuous, independent, and modest associations of Lp(a) concentration with risk of CHD and stroke that appear exclusive to vascular outcomes. ©2009 American Medical Association. All rights reserved.

Published
2009

278. Vandmiljø og Natur 2006:NOVANA. Tilstand og udvikling - faglig sammenfatning

Author

Boutrup, S., Bijl, Lilian van der, Nordemann Jensen, P., Svendsen, L. M., Grant, R., Bøgestrand, J., Jørgensen, T. B., Ellermann, T., Ærtebjerg, G., Pedersen, Marianne Bruus, Søgaard, B., Thorling, L., and Dahlgren, K.

Subjects
kvælstof, habitatområder, atmosfærisk nedfald, miljøfremmede stoffer, landbrug, pesticider, tungmetaller, habitatdirektiv, grundvand, søer, miljøtilstand, terrestrisk natur, havet, vandmiljøplan, spildevand, arter, fosfor
Abstract

Denne rapport indeholder resultater fra 2005 og 2006 af det nationale program for overvågning af vandmiljø og natur (NOVANA) i Danmark. Rapporten indeholder en opgørelse af de vigtigste påvirkningsfaktorer og en status for tilstand i grundvand, vandløb, søer, havet, samt for overvågningen af naturtyperne på land og for overvågning af udvalgte planter og dyr. Grundlaget for rapporten er de årlige rapporter, som udarbejdes af fagdatacentrene for de enkelte emneområder. Disse rapporter er baseret på data indsamlet og rapporteret af amterne.

Published
2007

279. Søer 2006:NOVANA

Author

Jørgensen, T. B., Bjerring, Rikke, Johansson, L. S., Søndergaard, M., Sortkjær, L., and Landkildehus, F.

Subjects
søøer, miljøtilstand, vandmiljøplan, NOVANA, overvågning
Published
2007

281. LIST OF PARTICIPANTS

Author

ÅBERG, S., primary, ABUL-MAGD, A., additional, AGODI, C., additional, dos AIDOS, F., additional, ARIMA, A., additional, ARNELL, S., additional, ARVE, P., additional, BACELAR, J., additional, BACK, B.B., additional, BACKTASH, C., additional, BALDO, M., additional, BANG, J., additional, BARRANCO, F., additional, BARZ, H.W., additional, BECKERMAN, M., additional, BEENE, J., additional, BENGTSSON, R., additional, BERGQVIST, I., additional, BERGSTRØSM, I., additional, BERTRAND, F.E., additional, BES, D., additional, BJERREGAARD, J.H., additional, BJØSRNHOLM, S., additional, BLASI, P., additional, BLOMQVIST, J., additional, de BOER, J., additional, BOHR, Aa., additional, BONDORF, J., additional, BORGGREEN, J., additional, BORTIGNON, P.F., additional, BOWMAN, J.D., additional, von BRENTANO, P., additional, BRIANCON, C., additional, BRITT, H.C., additional, BROGLIA, R.A., additional, BUTLER, P., additional, CAMACHO, J.G., additional, CARLEN, L., additional, CARPENTER, M., additional, CATARA, F., additional, CAVINATO, M., additional, CHAPMAN, R., additional, Yong-Shou, CHEN, additional, CHRISTENSEN, C., additional, CHRISTENSEN, P.R., additional, CLINE, D., additional, COOPERSTEIN, J., additional, COVELLO, A., additional, DASSO, C., additional, DEUTCH, B., additional, DIAMOND, R., additional, DJALALI, C., additional, DONANGELO, R., additional, DØSSING, T., additional, DRACOULIS, G., additional, DUDEK, J., additional, DUMITRESCU, T.S., additional, EGIDO, J.L., additional, ELBEK, B., additional, ELLEGAARD, C., additional, EMLING, H., additional, ENGELAND, T., additional, FABRICIUS, B., additional, FAESSLER, A., additional, FAHLANDER, C., additional, FANT, B., additional, FERNANDEZ, B., additional, FOLKMANN, F., additional, FOSSAN, D., additional, FRANDSEN, P., additional, FRISK, H., additional, FROIS, B., additional, GAARDE, C., additional, GAARDHØJE, J.J., additional, GAI, M., additional, GALES, S., additional, GARRETT, J., additional, GELBERG, A., additional, van GIAI, N., additional, GIZON, J., additional, GOLDRING, G., additional, GOODMAN, C., additional, GREEN, A.M., additional, GREEN, L., additional, GRODZINS, L., additional, GUTTORMSEN, M., additional, HAAS, B., additional, HAGEMANN, G., additional, HAMAMOTO, I., additional, HAMMAREN, E., additional, HANSEN, K., additional, HANSEN, O., additional, HANSEN, P.G., additional, HATTULA, J., additional, HEISENBERG, J.H., additional, HERSKIND, B., additional, HILTON, R., additional, HINTZ, N.M., additional, HOWE, D., additional, HUUS, T., additional, HÜBEL, H., additional, INGEBRETSEN, F., additional, JACKSON, A., additional, JAKOBSEN, B., additional, JANSSENS, R.V.F., additional, JÄÄSKELÄINEN, M., additional, STENHOLM JENSEN, A., additional, JOHNSON, A., additional, JOHNSON, N.R., additional, JØRGENSEN, T., additional, KANTELE, J., additional, KIENLE, A., additional, KLEINHEINZ, P., additional, KOONIN, S., additional, KOWNACKI, J., additional, LANDE, A., additional, SYRAK LARSEN, J., additional, LAURITZEN, B., additional, LAUTERBACH, C., additional, LEONARDI, R., additional, LIEDER, R.M., additional, LILLEY, J., additional, LINDBLAD, T., additional, LINDENBERGER, H., additional, LIOTTA, R., additional, LISLE, J., additional, LØVHØJDEN, G., additional, LYTTKENS, J., additional, MAGLIONE, E., additional, MAGNUSSON, S.M., additional, MAHAUX, C., additional, MAHNKE, H.-E., additional, MANG, J., additional, MARSHALEK, E., additional, MARTY, N., additional, MARUMORI, T., additional, MATSUYANAGI, K., additional, MIGNECO, E., additional, MO, J., additional, MONIZ, E.J., additional, MORINAGA, H., additional, MORSCH, H.P., additional, MOSHINSKY, M., additional, MOTOBA, T., additional, MOTTELSON, B., additional, NATHAN, O., additional, NAZAREWICZ, W., additional, NEERGAARD, K., additional, NESKAKIS, A., additional, NEWTON, J., additional, NILSSON, B., additional, NOLAN, P., additional, NOLTE, E., additional, NYAKO, B., additional, VON OERTZEN, H., additional, OGAZA, S., additional, OLESEN, M., additional, OSTERFELD, F., additional, PEDERSEN, J., additional, PIGNANELLI, M., additional, PLOSZAJZAK, M., additional, POLLAROLO, G., additional, RADFORD, D., additional, RAGNARSON, I., additional, RANDRUP, J., additional, REISDORF, W., additional, REKSTAD, J., additional, RHO, M., additional, RICCI, R.A., additional, RICHTER, A., additional, RIEDINGER, L., additional, RILEY, M., additional, RING, P., additional, RISKA, D.O., additional, ROECKL, E., additional, ROWLEY, N., additional, RYDE, H., additional, SAGAWA, H., additional, SCHIFFER, K., additional, SCHUCK, C., additional, SCHULZ, H., additional, SCHWALM, D., additional, SICK, I., additional, SIEMENS, P., additional, SIMON, R.S., additional, SIMPSON, J., additional, SKEPPSTEDT, Ö., additional, SLETTEN, G., additional, SNOVER, K., additional, SORENSEN, R.A., additional, SPROUSE, G., additional, STACHEL, J., additional, DELEPLANQUE-STEPHENS, M.-A., additional, STEPHENS, F., additional, STRUTINSKY, V.M., additional, SUJKOWSKI, Z., additional, SZYMANSKI, Z., additional, TANABE, K., additional, THORSTEINSEN, T., additional, TJØM, P.O., additional, TWIN, P., additional, ULFBECK, O., additional, URBAN, W., additional, VAAGEN, J., additional, VAGRADOV, G.M., additional, VAUTHERIN, D., additional, VENERONI, M., additional, VERGNES, M., additional, VIGEZZI, E., additional, VIHN MAU, N., additional, VITTURI, A., additional, VOGEL, P., additional, WALKER, P., additional, WALUS, W., additional, WARD, D., additional, WEIDENMÜLLER, H., additional, WENESER, J., additional, van der WERF, S.Y., additional, WESTERBERG, L., additional, WINTHER, Aa., additional, van der WOUDE, A., additional, Liqing, XIE, additional, Gong-Ou, XU, additional, YANG, C.X., additional, YOSHIZAWA, Y., additional, ZELEVINSKI, V., additional, Jing-Ye, ZHANG, additional, del ZOPPO, A., additional, and ZYLICZ, J., additional

Published
1985
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288. Helheim 2006: Integrated Geophysical Observations of Glacier Flow

Author

Nettles, M., Ahlstrøm, A., Elosegui, P., Hamilton, G., Kahn, S., Langer, M., Stearns, L., Lars Stenseng, Davis, J., Rkström, G., René Forsberg, Jørgensen, T., and Larsen, T.

Abstract

During the summer field season, 2006, we undertook a pilot geophysical experiment at Helheim Glacier, East Greenland, in which we deployed a network of GPS instruments on and around the glacier to measure the ice deformation field as a function of time. The experiment was motivated by the discovery of a new class of earthquakes occurring at glaciers in Alaska, Antarctica, and Greenland (Ekström, Nettles, and Abers, 2003). Teleseismic analysis indicates that these glacial earthquakes may result from the rapid sliding of the glacial ice over the glacier bed, and recent evidence (Ekström, Nettles, and Tsai, 2006) suggests a link to the hydrological cycle. However, little is understood about the mechanism by which the earthquakes occur. We installed sixteen GPS receivers on Helheim glacier, in a network spanning an upglacier distance of ~25~km from a point ~10~km behind the calving front. We also installed three GPS receivers at nearby rock sites to help define a stable reference frame. The stations were deployed in late June, 2006, and retrieved in late August, 2006. The GPS receivers recorded at a rate of at least 5~samples/sec. In addition, we operated several receivers for a few days each just behind the calving front during field visits in late June, late July, and late August, and we recorded the tidal stage using a pressure sensor near the end of Helheim Fjord for ~3~weeks during the experiment. Initial results show a variation in flow speed from about 25~m/day near the calving front to about 6~m/day at a location ~35~km behind the front. The horizontal flow speeds are tidally modulated, and an abrupt spatial change in vertical displacements due to the water tide gives the probable location of the glacier grounding line. We will present our geodetic results, and combine these results with seismological and glaciological observations to place constraints on the conditions under which glacial earthquakes are generated.

Published
2006

298. SAT0065 Effectiveness and Drug Adherence of Biologic Monotherapy in Danish Rheumatoid Arthritis Patients: A Cohort Study of Clinical Practice in the Danbio Registry

Author

Jørgensen, T., primary, Kristensen, L., additional, Christensen, R., additional, Bliddal, H., additional, Lorenzen, T., additional, Hansen, M., additional, Østergaard, M., additional, Jensen, J., additional, Zanjani, L., additional, Laursen, T., additional, Butt, S., additional, Dam, M., additional, Lindegaard, H., additional, Espesen, J., additional, Hendricks, O., additional, Kumar, P., additional, Kincses, A., additional, Larsen, L., additional, Andersen, M., additional, Næser, E., additional, Jensen, D., additional, Grydehøj, J., additional, Unger, B., additional, Dufour, N., additional, Sørensen, V., additional, Vildhøj, S., additional, Hansen, I., additional, Raun, J., additional, Krogh, N., additional, and Hetland, M., additional

Published
2014
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299. Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility

Author

Guigas, B., primary, de Leeuw van Weenen, J. E., additional, van Leeuwen, N., additional, Simonis-Bik, A. M., additional, van Haeften, T. W., additional, Nijpels, G., additional, Houwing-Duistermaat, J. J., additional, Beekman, M., additional, Deelen, J., additional, Havekes, L. M., additional, Penninx, B. W. J. H., additional, Vogelzangs, N., additional, van ‘t Riet, E., additional, Dehghan, A., additional, Hofman, A., additional, Witteman, J. C., additional, Uitterlinden, A. G., additional, Grarup, N., additional, Jørgensen, T., additional, Witte, D. R., additional, Lauritzen, T., additional, Hansen, T., additional, Pedersen, O., additional, Hottenga, J., additional, Romijn, J. A., additional, Diamant, M., additional, Kramer, M. H. H., additional, Heine, R. J., additional, Willemsen, G., additional, Dekker, J. M., additional, Eekhoff, E. M., additional, Pijl, H., additional, de Geus, E. J., additional, Slagboom, P. E., additional, and ‘t Hart, L. M., additional

Published
2014
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