628,203 results on '"Levy A"'
Search Results
252. Unsedated colonoscopy utilizing virtual reality distraction: a pilot-controlled study
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Veisman, Ido, Tardio Duchan, Moran, Lahat, Adi, Goldenfeld, Miki, Ukashi, Offir, Laish, Ido, Lang, Alon, Albshesh, Ahmad, Margalit Yehuda, Reuma, Senderowich, Yuval, Livne Margolin, Moran, Yablecovitch, Doron, Dvir, Revital, Neuman, Sandra, Ben-Horin, Shomron, and Levy, Idan
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- 2024
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253. Unilateral versus bilateral pedicle screw fixation with anterior lumbar interbody fusion: a comparison of postoperative outcomes
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Levy, Hannah A., Pumford, Andrew, Kelley, Brian, Allen, Tyler G., Pinter, Zachariah W., Girdler, Steven J., Bydon, Mohamad, Fogelson, Jeremy L., Elder, Benjamin D., Currier, Bradford, Nassr, Ahmad N., Karamian, Brian A., Freedman, Brett A., and Sebastian, Arjun S.
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- 2024
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254. Spinal movement disorders in NMOSD, MOGAD, and idiopathic transverse myelitis: a prospective observational study
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Abboud, Hesham, Sun, Rongyi, Modak, Nikhil, Elkasaby, Mohamed, Wang, Alexander, and Levy, Michael
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- 2024
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255. The Impact of the COVID-19 Pandemic on Adolescent Substance Use
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Ross, Jennifer A., Weitzman, Elissa R., and Levy, Sharon
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- 2024
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256. Exploring Clinical Remission in Moderate Asthma – Perspectives from Asia, the Middle East, and South America
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Maneechotesuwan, Kittipong, Aggarwal, Bhumika, Garcia, Gabriel, Tan, Daniel, Neffen, Hugo, Javier, Ramon Jason M., Al-Ahmad, Mona, Khadada, Mousa, Quan, Vu Tran Thien, Teerapuncharoen, Krittika, Ramos, Mario Soto, Levy, Gur, Plank, Maximilian, Phansalkar, Abhay, and Gibson, Peter G.
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- 2024
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257. Antifungal activity of β-lapachone against a fluconazole-resistant Candida auris strain
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de Moraes, Daniel Clemente, Rollin-Pinheiro, Rodrigo, Pinto, Maria do Carmo Freire Ribeiro, Domingos, Levy Tenório Sousa, Barreto-Bergter, Eliana, and Ferreira-Pereira, Antonio
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- 2024
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258. Gender Disparities in Valvular Heart Disease and Treatment in the Aging Population
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Desmarais, Taylor, Dichiacchio, Laura, Fanous, Hanna, Levy, Lauren, Pereira, Sara J., and Jones, Tara L.
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- 2024
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259. Parasite assemblages as indicators of stability in stock structure of Cynoscion guatucupa (Sciaenidae) after a quarter of century of exploitation in a marine warming hotspot
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Lanfranchi, Ana L., Canel, Delfina, Alarcos, Ana J., Levy, Eugenia, Braicovich, Paola E., Marcotegui, Paula, and Timi, Juan T.
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- 2024
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260. Crack nucleation in heterogeneous bars: h- and p-FEM of a phase field model
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Levy, Maxime, Vicentini, Francesco, and Yosibash, Zohar
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- 2024
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261. Chromosomal microarray testing yield in 829 cases of microcephaly: a clinical characteristics-based analysis for prenatal and postnatal cases
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Sukenik-Halevy, Rivka, Mevorach, Nir, Basel-Salmon, Lina, Matar, Reut Tomashov, Kahana, Sarit, Klein, Kochav, Agmon-Fishman, Ifaat, Levy, Michal, and Maya, Idit
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- 2024
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262. Does the combination of four OGTT values enhance the prediction of adverse pregnancy outcomes? Insights from a retrospective cohort study
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Mor, Liat, Toledano, Ella, Ben-Shoshan, Noa, Weiner, Eran, Paz, Yael Ganor, Barda, Giulia, and Levy, Michal
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- 2024
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263. Mental Health and Physical Activity Level in Military Police Officers from Sergipe, Brazil
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Victor Matheus Santos do Nascimento, Levy Anthony Souza de Oliveira, Luan Lopes Teles, Davi Pereira Monte Oliveira, Nara Michelle Moura Soares, and Roberto Jerônimo dos Santos Silva
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Medicine ,Sports medicine ,RC1200-1245 - Abstract
The objective of the present study was to analyse the association between the level of physical activity and mental health indicators in this population. A total of 254 military police officers, male and female, aged between 21 and 55, participated in military battleships and police companies in the metropolitan region of Aracaju, Sergipe. They responded to an assessment form, available online, on Google Forms, containing questions about socio-demographic, anthropometric and occupational characteristics, quality of sleep (Pittsburgh scale), stress (EPS-10), anxiety and depression (HAD scale), Exhaustion syndrome (MBI - GS), suicidal ideation (YRBSS - adapted), and Physical Activity level (IPAQ-short). Officers classified as “insufficiently active” had a higher risk for “burnout syndrome” (OR = 2.49; CI: 95% 1.42-4.43) and a greater feeling of “deep sadness” (OR = 1.85; CI: 95% 1.03-3.33) compared with physically active colleagues. In addition, longer service time was a protective factor against anxiety (OR = 0.30; CI: 95% 0.13-0.68), burnout syndrome (OR = 0.28; CI: 95% 0.12 -0.67) and deep sadness (OR = 0.25; CI: 95% 0.11-0.57). Older officers are more likely to be affected by “deep sadness” (OR = 2.80; CI: 95% 1.37-5.71). It was concluded that physical activity is associated with changes in the mental health of the police officers evaluated.
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- 2020
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264. Modalidades 'Cross': Os Modelos AMRAP, RFT e EMOM são aplicáveis no contexto da Saúde?
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Marzo Edir Da Silva-Grigoletto, Juan Ramón Heredia-Elvar, and Levy Anthony de Oliveira
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Educação Física e Treinamento ,Estilo de Vida Saudável ,Exercício Físico ,Sports ,GV557-1198.995 ,Medicine (General) ,R5-920 - Abstract
Atualmente, os modelos de treinamento em que são executados o número máximo de repetições/rounds ou se completa a tarefa proposta no menor tempo possível têm sido muito utilizados por grande parte dos profissionais de Educação Física. Contudo, ao nosso ver, tais modelos possuem importantes inconvenientes que contrapõem sua utilização dentro do contexto da saúde. Assim, nós fornecemos uma análise dos problemas relacionados ao controle da magnitude da carga de treinamento (volume e intensidade), a distribuição, duração e características das recuperações e, logicamente, da densidade intra-sessão. Esta análise foi realizada sem ter medido diretamente cada uma dessas propostas e se baseia na lógica da dinâmica dos esforços realizados e da potencial fadiga gerada.Em breve, esperamos poder verificar e fornecer os dados específicos para confirmar esta análise.
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- 2020
265. Hemovigilance and patient safety: analysis of immediate transfusion reactions in elderly
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Paola Almeida dos Santos Sobral, Leila Bernarda Donato Göttems, and Levy Aniceto Santana
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Transfusion Reaction ,Blood Safety ,Patient Safety ,Blood Component Transfusion ,Quality of Health Care ,Aged ,Nursing ,RT1-120 - Abstract
ABSTRACT Objective: To identify immediate transfusion reactions in elders hospitalized in a public hospital in the Federal District. Methods: This is an observational, retrospective, documental, and analytical research, with a quantitative analysis of 516 transfusions of packed red blood cells in elders hospitalized in the largest public hospital, who required blood components, from June to December 2017, through descriptive statistics. Results: The sample corresponded to 46.36% of the total number of transfusions in elders in the period. The mean age was 70 years old. There were adverse effects (reactions to the transfusion) in 12 (2.3%) transfusions. Respiratory alterations (33.3%) and fever (23.8%) were the most common events. Conclusion: The incidence of reactions to the transfusion is below national and international rates, indicating probable undernotification, which could be associated to a lack of knowledge regarding its clinical manifestations and the lack of systematic monitoring of the transfusion.
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- 2020
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266. STOP-Bang questionnaire should be used in all adults with Down Syndrome to screen for moderate to severe obstructive sleep apnea.
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Anderson Albuquerque de Carvalho, Fabio Ferreira Amorim, Levy Aniceto Santana, Karlo Jozefo Quadros de Almeida, Alfredo Nicodemos Cruz Santana, and Francisco de Assis Rocha Neves
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Medicine ,Science - Abstract
STUDY OBJECTIVES:To determine the prevalence of obstructive sleep apnea (OSA) in adults with Down syndrome (DS), to investigate factors related to OSA severity and to identify which sleep questionnaire is the most appropriate for the screening of OSA in this population. METHODS:Cross-sectional study that consecutively included 60 adults with DS. All patients underwent type III polysomnography and clinical and laboratory data were collected; sleep assessment questionnaires were applied. Multiple linear regression models evaluated the associations between OSA severity (measured by the respiratory event index-REI) and clinical and laboratory data and sleep questionnaires (Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, BERLIN and STOP-Bang questionnaires). RESULTS:Results show that 60 (100%) adults with DS had OSA, with moderate-severe OSA identified in 49 (81.6%). At the multivariate linear regression, REI significantly correlated with hematocrit levels, BMI and STOP-Bang questionnaire (SBQ) results (P
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- 2020
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267. Adesão às boas práticas de atenção ao parto e nascimento e análise da confiabilidade de um instrumento pelo alfa de Cronbach
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Leila Bernarda Donato Göttems, Elisabete Mesquita Peres de Carvalho, Paloma Aparecida Carvalho, and Levy Aniceto Santana
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Medicine ,Nursing ,RT1-120 - Published
- 2018
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268. Avaliação computacional do volume de lesão por pressão simulada por meio de variação de feixes luminosos e sombras
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Levy Aniceto Santana, Edvar Ferreira da Rocha Júnior, Renato da Veiga Guadagnin, and Paola Almeida dos Santos Sobral
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Medicine ,Nursing ,RT1-120 - Published
- 2018
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269. Meta-analysis of the association of the haptoglobin genotype with cardiovascular outcomes and the pharmacogenomic interactions with vitamin E supplementation
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Asleh R, Briasoulis A, Berinstein EM, Wiener JB, Palla M, Kushwaha SS, and Levy AP
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haptoglobin genotype ,diabetes mellitus ,vitamin E ,cardiovascular disease ,antioxidants ,high density lipoprotein (HDL) dysfunction ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Rabea Asleh,1,2 Alexandros Briasoulis,3 Elliot M Berinstein,1 Joshua B Wiener,1 Mohan Palla,4 Sudhir S Kushwaha,2 Andrew P Levy1 1Bruce and Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel; 2Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA; 3Division of Cardiovascular Diseases, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; 4Department of Cardiology, Detroit Medical Center, Wayne State University, Detroit, MI, USA Objectives: The objectives of the study were to compile and summarize the data from all of the clinical trials designed to examine the association between haptoglobin (Hp) genotype and incidence of cardiovascular (CV) events in patients with diabetes mellitus (DM) and to assess the impact of vitamin E treatment on CV outcomes according to the Hp genotype.Background: The Hp genotype could serve as a predictive biomarker to DM patients who may benefit from vitamin E therapy.Methods: The electronic databases MEDLINE, PubMed, EMBASE and the Cochrane Library for Central Register of Clinical Trials were searched systematically using the following MESH terms: “haptoglobin genotype”, “diabetes mellitus” and “cardiovascular events”.Results: Overall, 13 studies fit the inclusion criteria for this analysis, yielding a large study population that included 6,161 patients without Hp 2-2 and 4,684 patients with Hp 2-2. The analysis of these studies showed that the incidence of CV events in DM patients with the Hp 2-2 genotype was significantly increased as compared to non-Hp 2-2 patients in all three subgroups of case–control (OR: 2.2, 95% CI: 1.3–3.6; P=0.003), cohort (OR: 1.3, 95% CI: 1.2–1.5; P=0.001) and randomized controlled trials (OR: 1.6, 1.2–2.2; P=0.005). Among patients with the Hp 2-2 genotype, administration of vitamin E was associated with lower rates of CV events (OR: 0.66, 95% CI: 0.45–0.95; P=0.025). Further investigation into the association between Hp 2-2 and myocardial infarction, stroke, mortality and end-stage renal disease was also performed.Conclusion: The Hp genotype is a risk factor for CV events in patients with DM, and administration of vitamin E appears to offer a low cost and accessible means of reducing CV events and mortality in this population. Keywords: haptoglobin genotype, diabetes mellitus, vitamin E, cardiovascular disease, antioxidants, HDL dysfunction
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- 2018
270. Preparing Pre-College Students for the Second Quantum Revolution with Core Concepts in Quantum Information Science
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Singh, Chandralekha, Levy, Akash, and Levy, Jeremy
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Physics - Physics Education - Abstract
After the passage of the US National Quantum Initiative Act in December 2018, the National Science Foundation and the Office of Science and Technology Policy assembled an interagency working group and conducted a workshop titled "Key Concepts for Future Quantum Information Science Learners" that focused on identifying core concepts for future curricular and educator activities to help pre-college students engage with quantum information science (QIS). Helping pre-college students learn these key concepts in QIS is an effective approach to introducing them to the Second Quantum Revolution and inspiring them to become future contributors in the growing field of quantum information science and technology as leaders in areas related to quantum computing, communication and sensing. This paper is a call to pre-college educators to contemplate including QIS concepts into their existing courses at appropriate levels and get involved in the development of curricular materials suitable for their students. Also, research shows that compare and contrast activities can provide an effective approach to helping students learn. Therefore, we illustrate a pedagogical approach that contrasts the classical and quantum concepts so that educators could adapt them for their students in their lesson plans to help them learn the differences between key concepts in quantum and classical contexts.
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- 2023
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271. SAT, Gadgets, Max2XOR, and Quantum Annealers
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Ansótegui, Carlos and Levy, Jordi
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Quantum Physics ,Computer Science - Computational Complexity ,Computer Science - Logic in Computer Science - Abstract
Quantum Annealers are basically quantum computers that with high probability can optimize certain quadratic functions on Boolean variables in constant time. These functions are basically the Hamiltonian of Ising models that reach the ground energy state, with a high probability, after an annealing process. They have been proposed as a way to solve SAT. These Hamiltonians can be seen as Max2XOR problems, i.e. as the problem of finding an assignment that maximizes the number of XOR clauses of at most 2 variables that are satisfied. In this paper, we present several gadgets to reduce SAT to Max2XOR. We show how they can be used to translate SAT instances to initial configurations of a quantum annealer., Comment: arXiv admin note: text overlap with arXiv:2204.01774
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- 2024
272. Supercurrent through an Andreev trimer
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Bordin, Alberto, Evertsz', Florian J. Bennebroek, Steffensen, Gorm O., Dvir, Tom, Mazur, Grzegorz P., van Driel, David, van Loo, Nick, Wolff, Jan Cornelis, Bakkers, Erik P. A. M., Yeyati, Alfredo Levy, and Kouwenhoven, Leo P.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Detection and control of Andreev Bound States (ABSs) localized at semiconductor-superconductor interfaces are essential for their use in quantum applications. Here we investigate the impact of ABSs on the supercurrent through a Josephson junction containing a quantum dot (QD). Additional normal-metal tunneling probes on both sides of the junction unveil the ABSs residing at the semi-superconductor interfaces. Such knowledge provides an ingredient missing in previous studies, improving the connection between theory and experimental data. By varying the ABS energies using electrostatic gates, we show control of the switching current, with the ability to alter it by more than an order of magnitude. Finally, the large degree of ABS tunability allows us to realize a three-site ABS-QD-ABS molecule (Andreev trimer) in which the central QD is screened by both ABSs. This system is studied simultaneously using both supercurrent and spectroscopy.
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- 2024
273. YSR Bond Qubit in a Double Quantum Dot with cQED Operation
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Steffensen, Gorm Ole and Yeyati, Alfredo Levy
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Connecting two half-filled quantum dots to two superconducting leads induces a competition of bonds, with the dots forming either an interdot exchange bond or two individual Yu-Shiba-Rusinov (YSR) screening bonds with the leads. Defining a qubit using these singlet parity bonding states provides dot charge noise protection, attributed to the chargeless nature of the screening quasiparticles, and magnetic noise protection, as the bonds guard against magnetic polarization. In this paper, we propose embedding a Double Quantum Dot (DQD) Josephson junction in parallel with a transmon to enable circuit Quantum Electrodynamics (cQED) measurements and operation of a YSR bond qubit. We demonstrate that, under realistic parameters, two-tone spectroscopy of the DQD can be performed, revealing a significant parameter regime suitable for qubit operation. Additionally, coherent manipulations of the bond states can be achieved through dot gates, and single-shot readout is enabled by measurements of a capacitively coupled resonator. Finally, we analyze noise sources and estimate gate noise on couplings as the primary source of qubit decoherence. Since this qubit is protected against nuclear Overhauser fields and does not rely on spin-orbit interactions for operation, a broader range of material platforms becomes available compared to current Andreev spin qubits.
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- 2024
274. Multi-Human Mesh Recovery with Transformers
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Wang, Zeyu, Weng, Zhenzhen, and Yeung-Levy, Serena
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Conventional approaches to human mesh recovery predominantly employ a region-based strategy. This involves initially cropping out a human-centered region as a preprocessing step, with subsequent modeling focused on this zoomed-in image. While effective for single figures, this pipeline poses challenges when dealing with images featuring multiple individuals, as different people are processed separately, often leading to inaccuracies in relative positioning. Despite the advantages of adopting a whole-image-based approach to address this limitation, early efforts in this direction have fallen short in performance compared to recent region-based methods. In this work, we advocate for this under-explored area of modeling all people at once, emphasizing its potential for improved accuracy in multi-person scenarios through considering all individuals simultaneously and leveraging the overall context and interactions. We introduce a new model with a streamlined transformer-based design, featuring three critical design choices: multi-scale feature incorporation, focused attention mechanisms, and relative joint supervision. Our proposed model demonstrates a significant performance improvement, surpassing state-of-the-art region-based and whole-image-based methods on various benchmarks involving multiple individuals.
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- 2024
275. Same Task, More Tokens: the Impact of Input Length on the Reasoning Performance of Large Language Models
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Levy, Mosh, Jacoby, Alon, and Goldberg, Yoav
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
This paper explores the impact of extending input lengths on the capabilities of Large Language Models (LLMs). Despite LLMs advancements in recent times, their performance consistency across different input lengths is not well understood. We investigate this aspect by introducing a novel QA reasoning framework, specifically designed to assess the impact of input length. We isolate the effect of input length using multiple versions of the same sample, each being extended with padding of different lengths, types and locations. Our findings show a notable degradation in LLMs' reasoning performance at much shorter input lengths than their technical maximum. We show that the degradation trend appears in every version of our dataset, although at different intensities. Additionally, our study reveals that the traditional metric of next word prediction correlates negatively with performance of LLMs' on our reasoning dataset. We analyse our results and identify failure modes that can serve as useful guides for future research, potentially informing strategies to address the limitations observed in LLMs., Comment: Accepted to ACL 2024
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- 2024
276. Conservation of Ramsey's theorem for pairs and well-foundedness
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Houérou, Quentin Le, Patey, Ludovic Levy, and Yokoyama, Keita
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Mathematics - Logic - Abstract
In this article, we prove that Ramsey's theorem for pairs and two colors is $\Pi^1_1$-conservative over~$\mathsf{RCA}_0 + \mathsf{B}\Sigma^0_2 + \mathsf{WF}(\epsilon_0)$ and over~$\mathsf{RCA}_0 + \mathsf{B}\Sigma^0_2 + \bigcup_n \mathsf{WF}(\omega^\omega_n)$. These results improve theorems from Chong, Slaman and Yang and Ko{\l}odziejczyk and Yokoyama and belong to a long line of research towards the characterization of the first-order part of Ramsey's theorem for pairs., Comment: 36 pages
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- 2024
277. Sign of the $hZZ$ coupling and implication for new physics
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Das, Dipankar, Kundu, Anirban, Levy, Miguel, Prasad, Anugrah M., Saha, Ipsita, and Sarkar, Agnivo
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
The magnitudes of the couplings of the scalar resonance at 125 GeV with the SM particles are found to be consistent with those of the SM Higgs boson. However, the signs are not experimentally determined in most of the cases, a prime example being that with the $Z$-boson pair. In other words, $\kappa_Z^h$, the ratio of the couplings of the actual 125 GeV resonance with $ZZ$ and that of the SM Higgs boson with the same, is consistent with both $+1$ and $-1$, the latter being the `wrong-sign'. We argue that the wrong-sign $hZZ$ coupling will necessitate the intervention of new physics below $\mathcal{O}\left(620\right)$ GeV to safeguard the underlying theory from unitarity violation. The strength of the new nonstandard couplings can be derived from the unitarity sum rules, which are comparable to the SM-Higgs couplings in magnitude. Thus the strong limits from the direct searches at the LHC can help us rule out the existence of such nonstandard particles with unusually large couplings thereby disfavoring the possibility of a wrong-sign $hZZ$ coupling., Comment: 8 pages, 3 figures
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- 2024
278. Moonwalk: Advancing Gait-Based User Recognition on Wearable Devices with Metric Learning
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Liberman, Asaf, Levy, Oron, Shahi, Soroush, Park, Cori Tymoszek, Ralph, Mike, Kang, Richard, Bedri, Abdelkareem, and Laput, Gierad
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Computer Science - Human-Computer Interaction ,H.5.2 - Abstract
Personal devices have adopted diverse authentication methods, including biometric recognition and passcodes. In contrast, headphones have limited input mechanisms, depending solely on the authentication of connected devices. We present Moonwalk, a novel method for passive user recognition utilizing the built-in headphone accelerometer. Our approach centers on gait recognition; enabling users to establish their identity simply by walking for a brief interval, despite the sensor's placement away from the feet. We employ self-supervised metric learning to train a model that yields a highly discriminative representation of a user's 3D acceleration, with no retraining required. We tested our method in a study involving 50 participants, achieving an average F1 score of 92.9% and equal error rate of 2.3%. We extend our evaluation by assessing performance under various conditions (e.g. shoe types and surfaces). We discuss the opportunities and challenges these variations introduce and propose new directions for advancing passive authentication for wearable devices.
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- 2024
279. Vision-Based Hand Gesture Customization from a Single Demonstration
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Shahi, Soroush, Mollyn, Vimal, Park, Cori Tymoszek, Kang, Richard, Liberman, Asaf, Levy, Oron, Gong, Jun, Bedri, Abdelkareem, and Laput, Gierad
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Computer Science - Human-Computer Interaction ,H.5.2 ,I.4 - Abstract
Hand gesture recognition is becoming a more prevalent mode of human-computer interaction, especially as cameras proliferate across everyday devices. Despite continued progress in this field, gesture customization is often underexplored. Customization is crucial since it enables users to define and demonstrate gestures that are more natural, memorable, and accessible. However, customization requires efficient usage of user-provided data. We introduce a method that enables users to easily design bespoke gestures with a monocular camera from one demonstration. We employ transformers and meta-learning techniques to address few-shot learning challenges. Unlike prior work, our method supports any combination of one-handed, two-handed, static, and dynamic gestures, including different viewpoints, and the ability to handle irrelevant hand movements. We implement three real-world applications using our customization method, conduct a user study, and achieve up to 94% average recognition accuracy from one demonstration. Our work provides a viable path for vision-based gesture customization, laying the foundation for future advancements in this domain., Comment: 2024 (UIST' 24). USA, 14 pages
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- 2024
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280. New constraints on ultraheavy dark matter from the LZ experiment
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Aalbers, J., Akerib, D. S., Musalhi, A. K. Al, Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Baker, A., Balashov, S., Bang, J., Bargemann, J. W., Baxter, A., Beattie, K., Benson, T., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Bishop, E., Blockinger, G. M., Boxer, B., Brew, C. A. J., Brás, P., Burdin, S., Buuck, M., Carmona-Benitez, M. C., Carter, M., Chawla, A., Chen, H., Cherwinka, J. J., Chott, N. I., Converse, M. V., Cottle, A., Cox, G., Curran, D., Dahl, C. E., David, A., Delgaudio, J., Dey, S., de Viveiros, L., Ding, C., Dobson, J. E. Y., Druszkiewicz, E., Eriksen, S. R., Fan, A., Fearon, N. M., Fiorucci, S., Flaecher, H., Fraser, E. D., Fruth, T. M. A., Gaitskell, R. J., Geffre, A., Genovesi, J., Ghag, C., Gibbons, R., Gokhale, S., Green, J., van der Grinten, M. G. D., Hall, C. R., Han, S., Hartigan-O'Connor, E., Haselschwardt, S. J., Hertel, S. A., Heuermann, G., Homenides, G. J., Horn, M., Huang, D. Q., Hunt, D., Ignarra, C. M., Jacquet, E., James, R. S., Johnson, J., Kaboth, A. C., Kamaha, A. C., Khaitan, D., Khazov, A., Khurana, I., Kim, J., Kingston, J., Kirk, R., Kodroff, D., Korley, L., Korolkova, E. V., Kraus, H., Kravitz, S., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Lee, J., Leonard, D. S., Lesko, K. T., Levy, C., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Lopes, M. I., Asamar, E. Lopez, Lorenzon, W., Lu, C., Luitz, S., Majewski, P. A., Manalaysay, A., Mannino, R. L., Maupin, C., McCarthy, M. E., McDowell, G., McKinsey, D. N., McLaughlin, J., McMonigle, R., Miller, E. H., Mizrachi, E., Monte, A., Monzani, M. E., Mendoza, J. D. Morales, Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naylor, A., Nedlik, C., Nelson, H. N., Neves, F., Nguyen, A., Nikoleyczik, J. A., Olcina, I., Oliver-Mallory, K. C., Orpwood, J., Palladino, K. J., Palmer, J., Pannifer, N. J., Parveen, N., Patton, S. J., Penning, B., Pereira, G., Perry, E., Pershing, T., Piepke, A., Qie, Y., Reichenbacher, J., Rhyne, C. A., Riffard, Q., Rischbieter, G. R. C., Riyat, H. S., Rosero, R., Rushton, T., Rynders, D., Santone, D., Sazzad, A. B. M. R., Schnee, R. W., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Smith, R., Solovov, V. N., Sorensen, P., Soria, J., Stancu, I., Stevens, A., Stifter, K., Suerfu, B., Sumner, T. J., Szydagis, M., Taylor, W. C., Tiedt, D. R., Timalsina, M., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Tronstad, D. R., Turner, W., Vacheret, A., Vaitkus, A. C., Velan, V., Wang, A., Wang, J. J., Wang, Y., Watson, J. R., Webb, R. C., Weeldreyer, L., Whitis, T. J., Williams, M., Wisniewski, W. J., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Xia, Q., Xiang, X., Xu, J., Yeh, M., and Zweig, E. A.
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High Energy Physics - Experiment ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Searches for dark matter with liquid xenon time projection chamber experiments have traditionally focused on the region of the parameter space that is characteristic of weakly interacting massive particles, ranging from a few GeV/$c^2$ to a few TeV/$c^2$. Models of dark matter with a mass much heavier than this are well motivated by early production mechanisms different from the standard thermal freeze-out, but they have generally been less explored experimentally. In this work, we present a re-analysis of the first science run (SR1) of the LZ experiment, with an exposure of $0.9$ tonne$\times$year, to search for ultraheavy particle dark matter. The signal topology consists of multiple energy deposits in the active region of the detector forming a straight line, from which the velocity of the incoming particle can be reconstructed on an event-by-event basis. Zero events with this topology were observed after applying the data selection calibrated on a simulated sample of signal-like events. New experimental constraints are derived, which rule out previously unexplored regions of the dark matter parameter space of spin-independent interactions beyond a mass of 10$^{17}$ GeV/$c^2$., Comment: 9 pages, 7 figures
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- 2024
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281. WildfireGPT: Tailored Large Language Model for Wildfire Analysis
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Xie, Yangxinyu, Jiang, Bowen, Mallick, Tanwi, Bergerson, Joshua David, Hutchison, John K., Verner, Duane R., Branham, Jordan, Alexander, M. Ross, Ross, Robert B., Feng, Yan, Levy, Leslie-Anne, Su, Weijie, and Taylor, Camillo J.
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Computer Science - Artificial Intelligence - Abstract
Recent advancement of large language models (LLMs) represents a transformational capability at the frontier of artificial intelligence. However, LLMs are generalized models, trained on extensive text corpus, and often struggle to provide context-specific information, particularly in areas requiring specialized knowledge, such as wildfire details within the broader context of climate change. For decision-makers focused on wildfire resilience and adaptation, it is crucial to obtain responses that are not only precise but also domain-specific. To that end, we developed WildfireGPT, a prototype LLM agent designed to transform user queries into actionable insights on wildfire risks. We enrich WildfireGPT by providing additional context, such as climate projections and scientific literature, to ensure its information is current, relevant, and scientifically accurate. This enables WildfireGPT to be an effective tool for delivering detailed, user-specific insights on wildfire risks to support a diverse set of end users, including but not limited to researchers and engineers, for making positive impact and decision making.
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- 2024
282. E(3)-Equivariant Mesh Neural Networks
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Trang, Thuan, Ngo, Nhat Khang, Levy, Daniel, Vo, Thieu N., Ravanbakhsh, Siamak, and Hy, Truong Son
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Computer Science - Machine Learning - Abstract
Triangular meshes are widely used to represent three-dimensional objects. As a result, many recent works have address the need for geometric deep learning on 3D mesh. However, we observe that the complexities in many of these architectures does not translate to practical performance, and simple deep models for geometric graphs are competitive in practice. Motivated by this observation, we minimally extend the update equations of E(n)-Equivariant Graph Neural Networks (EGNNs) (Satorras et al., 2021) to incorporate mesh face information, and further improve it to account for long-range interactions through hierarchy. The resulting architecture, Equivariant Mesh Neural Network (EMNN), outperforms other, more complicated equivariant methods on mesh tasks, with a fast run-time and no expensive pre-processing. Our implementation is available at https://github.com/HySonLab/EquiMesh
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- 2024
283. Dynamic Byzantine-Robust Learning: Adapting to Switching Byzantine Workers
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Dorfman, Ron, Yehya, Naseem, and Levy, Kfir Y.
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Computer Science - Machine Learning ,Computer Science - Distributed, Parallel, and Cluster Computing ,Statistics - Machine Learning - Abstract
Byzantine-robust learning has emerged as a prominent fault-tolerant distributed machine learning framework. However, most techniques focus on the static setting, wherein the identity of Byzantine workers remains unchanged throughout the learning process. This assumption fails to capture real-world dynamic Byzantine behaviors, which may include intermittent malfunctions or targeted, time-limited attacks. Addressing this limitation, we propose DynaBRO -- a new method capable of withstanding any sub-linear number of identity changes across rounds. Specifically, when the number of such changes is $\mathcal{O}(\sqrt{T})$ (where $T$ is the total number of training rounds), DynaBRO nearly matches the state-of-the-art asymptotic convergence rate of the static setting. Our method utilizes a multi-level Monte Carlo (MLMC) gradient estimation technique applied at the server to robustly aggregated worker updates. By additionally leveraging an adaptive learning rate, we circumvent the need for prior knowledge of the fraction of Byzantine workers., Comment: ICML 2024
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- 2024
284. JWST Observations of Starbursts: Polycyclic Aromatic Hydrocarbon Emission at the Base of the M 82 Galactic Wind
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Bolatto, Alberto D., Levy, Rebecca C., Tarantino, Elizabeth, Boyer, Martha L., Fisher, Deanne B., Leroy, Adam K., Cronin, Serena A., Klessen, Ralf S., Smith, J. D., Berg, Dannielle A., Boeker, Torsten, Boogaard, Leindert A., Ostriker, Eve C., Thompson, Todd A., Ott, Juergen, Lenkic, Laura, Lopez, Laura A., Dale, Daniel A., Veilleux, Sylvain, van der Werf, Paul P., Glover, Simon C. O., Sandstrom, Karin M., Skillman, Evan D., Chisholm, John, Villanueva, Vicente, Lai, Thomas S. -Y., Lopez, Sebastian, Mills, Elisabeth A. C., Emig, Kimberly L., Armus, Lee, Maya, Divakara, Meier, David S., De Looze, Ilse, Herrera-Camus, Rodrigo, Walter, Fabian, Relano, Monica, Koziol, Hannah B., Marvil, Joshua, Jimenez-Donaire, Maria J., and Martini, Paul
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Astrophysics - Astrophysics of Galaxies - Abstract
We present new observations of the central 1 kpc of the M 82 starburst obtained with the James Webb Space Telescope (JWST) near-infrared camera (NIRCam) instrument at a resolution ~0.05"-0.1" (~1-2 pc). The data comprises images in three mostly continuum filters (F140M, F250M, and F360M), and filters that contain [FeII] (F164N), H2 v=1-0 (F212N), and the 3.3 um PAH feature (F335M). We find prominent plumes of PAH emission extending outward from the central starburst region, together with a network of complex filamentary substructure and edge-brightened bubble-like features. The structure of the PAH emission closely resembles that of the ionized gas, as revealed in Paschen alpha and free-free radio emission. We discuss the origin of the structure, and suggest the PAHs are embedded in a combination of neutral, molecular, and photoionized gas., Comment: Submitted to The Astrophysical Journal
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- 2024
285. Comparative Analysis of Practical Identifiability Methods for an SEIR Model
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Saucedo, Omar, Laubmeier, Amanda, Tang, Tingting, Levy, Benjamin, Asik, Lale, Pollington, Tim, and Prosper, Olivia
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Statistics - Methodology ,Quantitative Biology - Populations and Evolution ,Quantitative Biology - Quantitative Methods - Abstract
Identifiability of a mathematical model plays a crucial role in parameterization of the model. In this study, we establish the structural identifiability of a Susceptible-Exposed-Infected-Recovered (SEIR) model given different combinations of input data and investigate practical identifiability with respect to different observable data, data frequency, and noise distributions. The practical identifiability is explored by both Monte Carlo simulations and a Correlation Matrix approach. Our results show that practical identifiability benefits from higher data frequency and data from the peak of an outbreak. The incidence data gives the best practical identifiability results compared to prevalence and cumulative data. In addition, we compare and distinguish the practical identifiability by Monte Carlo simulations and a Correlation Matrix approach, providing insights for when to use which method for other applications., Comment: Minor changes to clarify why structural identifiability with respect to incidence data was not perform
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- 2024
286. A Simple Model of Energy Threshold for Snowball Chambers
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Szydagis, M., Levy, C., Bolotnikov, A. E., Diwan, M. V., Homenides, G. J., Kamaha, A. C., Martin, J., Rosero, R., and Yeh, M.
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High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
Cloud and bubble chambers have historically been used for particle detection, capitalizing on supersaturation and superheating, respectively. Here we present new results from a prototype snowball chamber, in which an incoming particle triggers crystallization of a purified, supercooled liquid. We demonstrate, for the first time, simulation agreement with our first results from 5 years ago: the higher temperature of the freezing of water and significantly shorter time spent supercooled with respect to control in the presence of a Cf-252 fission neutron source. This is accomplished by combining Geant4 modeling of neutron interactions with the Seitz nucleation model used in superheated bubble chambers, including those seeking dark matter. We explore the possible implications of using this new technology for GeV-scale WIMP searches, especially in terms of spin-dependent proton coupling, and report the first supercooling of WbLS (water-based liquid scintillator)., Comment: 11 pages, 6 figures, 1 table, 4 equations, and 48 references. Submitted to the Universe special collection on dark matter
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- 2024
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287. Revisiting Active Learning in the Era of Vision Foundation Models
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Gupte, Sanket Rajan, Aklilu, Josiah, Nirschl, Jeffrey J., and Yeung-Levy, Serena
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Foundation vision or vision-language models are trained on large unlabeled or noisy data and learn robust representations that can achieve impressive zero- or few-shot performance on diverse tasks. Given these properties, they are a natural fit for active learning (AL), which aims to maximize labeling efficiency. However, the full potential of foundation models has not been explored in the context of AL, specifically in the low-budget regime. In this work, we evaluate how foundation models influence three critical components of effective AL, namely, 1) initial labeled pool selection, 2) ensuring diverse sampling, and 3) the trade-off between representative and uncertainty sampling. We systematically study how the robust representations of foundation models (DINOv2, OpenCLIP) challenge existing findings in active learning. Our observations inform the principled construction of a new simple and elegant AL strategy that balances uncertainty estimated via dropout with sample diversity. We extensively test our strategy on many challenging image classification benchmarks, including natural images as well as out-of-domain biomedical images that are relatively understudied in the AL literature. We also provide a highly performant and efficient implementation of modern AL strategies (including our method) at https://github.com/sanketx/AL-foundation-models., Comment: Accepted to TMLR
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- 2024
288. Hidden Gems on a Ring: Infant Massive Clusters and Their Formation Timeline Unveiled by ALMA, HST, and JWST in NGC 3351
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Sun, Jiayi, He, Hao, Batschkun, Kyle, Levy, Rebecca C., Emig, Kimberly, Rodriguez, M. Jimena, Hassani, Hamid, Leroy, Adam K., Schinnerer, Eva, Ostriker, Eve C., Wilson, Christine D., Bolatto, Alberto D., Mills, Elisabeth A. C., Rosolowsky, Erik, Lee, Janice C., Dale, Daniel A., Larson, Kirsten L., Thilker, David A., Ubeda, Leonardo, Whitmore, Bradley C., Williams, Thomas G., Barnes, Ashley. T., Bigiel, Frank, Chevance, Melanie, Glover, Simon C. O., Grasha, Kathryn, Groves, Brent, Henshaw, Jonathan D., Indebetouw, Remy, Jimenez-Donaire, Maria J., Klessen, Ralf S., Koch, Eric W., Liu, Daizhong, Mathur, Smita, Meidt, Sharon, Menon, Shyam H., Neumann, Justus, Pinna, Francesca, Querejeta, Miguel, Sormani, Mattia C., and Tress, Robin G.
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Astrophysics - Astrophysics of Galaxies - Abstract
We study young massive clusters (YMCs) in their embedded "infant" phase with $\sim0.\!^{\prime\prime}1$ ALMA, HST, and JWST observations targeting the central starburst ring in NGC 3351, a nearby Milky Way analog galaxy. Our new ALMA data reveal 18 bright and compact (sub-)millimeter continuum sources, of which 8 have counterparts in JWST images and only 6 have counterparts in HST images. Based on the ALMA continuum and molecular line data, as well as ancillary measurements for the HST and JWST counterparts, we identify 14 sources as infant star clusters with high stellar and/or gas masses (${\sim}10^5\;\mathrm{M_\odot}$), small radii (${\lesssim}\,5\;\mathrm{pc}$), large escape velocities ($6{-}10\;\mathrm{km/s}$), and short free-fall times ($0.5{-}1\;\mathrm{Myr}$). Their multiwavelength properties motivate us to divide them into four categories, likely corresponding to four evolutionary stages from starless clumps to exposed HII region-cluster complexes. Leveraging age estimates for HST-identified clusters in the same region, we infer an evolutionary timeline going from $\sim$1-2 Myr before cluster formation as starless clumps, to $\sim$4-6 Myr after as exposed HII region-cluster complexes. Finally, we show that the YMCs make up a substantial fraction of recent star formation across the ring, exhibit an non-uniform azimuthal distribution without a very coherent evolutionary trend along the ring, and are capable of driving large-scale gas outflows., Comment: 27 pages, 12 figures; ApJ accepted
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- 2024
289. Flaring Stars in a Non-targeted mm-wave Survey with SPT-3G
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Tandoi, C., Guns, S., Foster, A., Ade, P. A. R., Anderson, A. J., Ansarinejad, B., Archipley, M., Balkenhol, L., Benabed, K., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Bouchet, F. R., Bryant, L., Camphuis, E., Carlstrom, J. E., Cecil, T. W., Chang, C. L., Chaubal, P., Chichura, P. M., Chou, T. -L., Coerver, A., Crawford, T. M., Cukierman, A., Daley, C., de Haan, T., Dibert, K. R., Dobbs, M. A., Doussot, A., Dutcher, D., Everett, W., Feng, C., Ferguson, K. R., Fichman, K., Galli, S., Gambrel, A. E., Gardner, R. W., Ge, F., Goeckner-Wald, N., Gualtieri, R., Guidi, F., Halverson, N. W., Hivon, E., Holder, G. P., Holzapfel, W. L., Hood, J. C., Huang, N., Kéruzoré, F., Knox, L., Korman, M., Kornoelje, K., Kuo, C. -L., Lee, A. T., Levy, K., Lowitz, A. E., Lu, C., Maniyar, A., Menanteau, F., Millea, M., Montgomery, J., Moon, Y., Nakato, Y., Natoli, T., Noble, G. I., Novosad, V., Omori, Y., Padin, S., Pan, Z., Paschos, P., Phadke, K. A., Prabhu, K., Qu, Z., Quan, W., Rahimi, M., Rahlin, A., Reichardt, C. L., Reuter, C., Rouble, M., Ruhl, J. E., Schiappucci, E., Smecher, G., Sobrin, J. A., Stark, A. A., Stephen, J., Suzuki, A., Thompson, K. L., Thorne, B., Trendafilova, C., Tucker, C., Umilta, C., Vieira, J. D., Wan, Y., Wang, G., Whitehorn, N., Wu, W. L. K., Yefremenko, V., Young, M. R., and Zebrowski, J. A.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present a flare star catalog from four years of non-targeted millimeter-wave survey data from the South Pole Telescope (SPT). The data were taken with the SPT-3G camera and cover a 1500-square-degree region of the sky from $20^{h}40^{m}0^{s}$ to $3^{h}20^{m}0^{s}$ in right ascension and $-42^{\circ}$ to $-70^{\circ}$ in declination. This region was observed on a nearly daily cadence from 2019-2022 and chosen to avoid the plane of the galaxy. A short-duration transient search of this survey yields 111 flaring events from 66 stars, increasing the number of both flaring events and detected flare stars by an order of magnitude from the previous SPT-3G data release. We provide cross-matching to Gaia DR3, as well as matches to X-ray point sources found in the second ROSAT all-sky survey. We have detected flaring stars across the main sequence, from early-type A stars to M dwarfs, as well as a large population of evolved stars. These stars are mostly nearby, spanning 10 to 1000 parsecs in distance. Most of the flare spectral indices are constant or gently rising as a function of frequency at 95/150/220 GHz. The timescale of these events can range from minutes to hours, and the peak $\nu L_{\nu}$ luminosities range from $10^{27}$ to $10^{31}$ erg s$^{-1}$ in the SPT-3G frequency bands.
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- 2024
290. The EDGE-CALIFA Survey: An Extragalactic Database for Galaxy Evolution Studies
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Wong, Tony, Cao, Yixian, Luo, Yufeng, Bolatto, Alberto D., Sánchez, Sebastián F., Barrera-Ballesteros, Jorge K., Blitz, Leo, Colombo, Dario, Dannerbauer, Helmut, Green, Alex, Kalinova, Veselina, Khan, Ferzem, Kim, Andrew, Lacerda, Eduardo A. D., Leroy, Adam K., Levy, Rebecca C., Lin, Xincheng, Luo, Yuanze, Rosolowsky, Erik W., Rubio, Mónica, Teuben, Peter, Utomo, Dyas, Villanueva, Vicente, Vogel, Stuart N., and Wang, Xinyu
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Astrophysics - Astrophysics of Galaxies - Abstract
The EDGE-CALIFA survey provides spatially resolved optical integral field unit (IFU) and CO spectroscopy for 125 galaxies selected from the CALIFA Data Release 3 sample. The Extragalactic Database for Galaxy Evolution (EDGE) presents the spatially resolved products of the survey as pixel tables that reduce the oversampling in the original images and facilitate comparison of pixels from different images. By joining these pixel tables to lower dimensional tables that provide radial profiles, integrated spectra, or global properties, it is possible to investigate the dependence of local conditions on large-scale properties. The database is freely accessible and has been utilized in several publications. We illustrate the use of this database and highlight the effects of CO upper limits on the inferred slopes of the local scaling relations between stellar mass, star formation rate (SFR), and H$_2$ surface densities. We find that the correlation between H$_2$ and SFR surface density is the tightest among the three relations., Comment: 21 pages, accepted for publication in ApJS, see DOIs below for code and data access
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- 2024
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291. Template-Free Single-View 3D Human Digitalization with Diffusion-Guided LRM
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Weng, Zhenzhen, Liu, Jingyuan, Tan, Hao, Xu, Zhan, Zhou, Yang, Yeung-Levy, Serena, and Yang, Jimei
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Reconstructing 3D humans from a single image has been extensively investigated. However, existing approaches often fall short on capturing fine geometry and appearance details, hallucinating occluded parts with plausible details, and achieving generalization across unseen and in-the-wild datasets. We present Human-LRM, a diffusion-guided feed-forward model that predicts the implicit field of a human from a single image. Leveraging the power of the state-of-the-art reconstruction model (i.e., LRM) and generative model (i.e Stable Diffusion), our method is able to capture human without any template prior, e.g., SMPL, and effectively enhance occluded parts with rich and realistic details. Our approach first uses a single-view LRM model with an enhanced geometry decoder to get the triplane NeRF representation. The novel view renderings from the triplane NeRF provide strong geometry and color prior, from which we generate photo-realistic details for the occluded parts using a diffusion model. The generated multiple views then enable reconstruction with high-quality geometry and appearance, leading to superior overall performance comparing to all existing human reconstruction methods., Comment: Project Page: https://zzweng.github.io/humanlrm
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- 2024
292. Language models align with human judgments on key grammatical constructions
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Hu, Jennifer, Mahowald, Kyle, Lupyan, Gary, Ivanova, Anna, and Levy, Roger
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
Do large language models (LLMs) make human-like linguistic generalizations? Dentella et al. (2023) ("DGL") prompt several LLMs ("Is the following sentence grammatically correct in English?") to elicit grammaticality judgments of 80 English sentences, concluding that LLMs demonstrate a "yes-response bias" and a "failure to distinguish grammatical from ungrammatical sentences". We re-evaluate LLM performance using well-established practices and find that DGL's data in fact provide evidence for just how well LLMs capture human behaviors. Models not only achieve high accuracy overall, but also capture fine-grained variation in human linguistic judgments., Comment: Published in PNAS at https://www.pnas.org/doi/10.1073/pnas.2400917121 as response to Dentella et al. (2023)
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- 2024
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293. DEM: A Method for Certifying Deep Neural Network Classifier Outputs in Aerospace
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Katz, Guy, Levy, Natan, Refaeli, Idan, and Yerushalmi, Raz
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Computer Science - Software Engineering ,Computer Science - Machine Learning - Abstract
Software development in the aerospace domain requires adhering to strict, high-quality standards. While there exist regulatory guidelines for commercial software in this domain (e.g., ARP-4754 and DO-178), these do not apply to software with deep neural network (DNN) components. Consequently, it is unclear how to allow aerospace systems to benefit from the deep learning revolution. Our work here seeks to address this challenge with a novel, output-centric approach for DNN certification. Our method employs statistical verification techniques, and has the key advantage of being able to flag specific inputs for which the DNN's output may be unreliable - so that they may be later inspected by a human expert. To achieve this, our method conducts a statistical analysis of the DNN's predictions for other, nearby inputs, in order to detect inconsistencies. This is in contrast to existing techniques, which typically attempt to certify the entire DNN, as opposed to individual outputs. Our method uses the DNN as a black-box, and makes no assumptions about its topology. We hope that this work constitutes another step towards integrating DNNs in safety-critical applications - especially in the aerospace domain, where high standards of quality and reliability are crucial., Comment: This is a preprint version of a paper that will appear at 43rd Digital Avionics Systems Conference (DASC 2024)
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- 2024
294. Pruning: a tool to optimize the layout of large scale arrays for ultra-high-energy air-shower detection
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Benoit-Lévy, Kotera, K., and Tueros, M.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The deployment of several large scale arrays is envisioned to study astroparticles at ultra-high energies. In order to circumvent the heavy computational costs of exploring and optimizing their layouts, we have developed a pruning method. It consists in i) running a set of microscopic simulations and interpolate them over a dense, regularly spaced array of detection units, and ii) pruning the unnecessary units out of the layout, in order to obtain the shower footprint on a newly shaped layout. This method offers flexibility to test various layout parameters, instrumental constraints, and physical inputs, with a drastic reduction in the required CPU time. The method can be universally applied to optimize arrays of any size, and using any detection techniques. For demonstration, we apply the pruning tool to radio antenna layouts, which allows us to discuss the interplay between the energy and inclination of air-showers on the size of the radio footprint and the intensity of the signal on the ground. Some rule-of-thumb conclusions that can be drawn for this specific case are: i) a hexagonal geometry is more efficient than a triangular geometry, ii) the detection efficiency of the array is stable to changes in the spacing between radio antennas around 1000m step size, iii) for a given number of antennas, adding a granular infill on top of a coarse hexagonal array is more efficient than instrumenting the full array with a less dense spacing., Comment: Submitted to JINST
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- 2024
295. Machine learning models for predicting blood pressure phenotypes by combining multiple polygenic risk scores.
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Hrytsenko, Yana, Shea, Benjamin, Elgart, Michael, Kurniansyah, Nuzulul, Lyons, Genevieve, Morrison, Alanna, Carson, April, Haring, Bernhard, Mitchell, Braxton, Psaty, Bruce, Jaeger, Byron, Gu, C, Kooperberg, Charles, Levy, Daniel, Lloyd-Jones, Donald, Choi, Eunhee, Brody, Jennifer, Smith, Jennifer, Rotter, Jerome, Moll, Matthew, Fornage, Myriam, Simon, Noah, Castaldi, Peter, Casanova, Ramon, Chung, Ren-Hua, Kaplan, Robert, Loos, Ruth, Kardia, Sharon, Rich, Stephen, Redline, Susan, Kelly, Tanika, OConnor, Timothy, Zhao, Wei, Kim, Wonji, Guo, Xiuqing, Ida Chen, Yii-Der, and Sofer, Tamar
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Humans ,Machine Learning ,Blood Pressure ,Multifactorial Inheritance ,Phenotype ,Genome-Wide Association Study ,Risk Factors ,Male ,Female ,Genetic Predisposition to Disease ,Models ,Genetic ,Hypertension ,Middle Aged ,Genetic Risk Score - Abstract
We construct non-linear machine learning (ML) prediction models for systolic and diastolic blood pressure (SBP, DBP) using demographic and clinical variables and polygenic risk scores (PRSs). We developed a two-model ensemble, consisting of a baseline model, where prediction is based on demographic and clinical variables only, and a genetic model, where we also include PRSs. We evaluate the use of a linear versus a non-linear model at both the baseline and the genetic model levels and assess the improvement in performance when incorporating multiple PRSs. We report the ensemble models performance as percentage variance explained (PVE) on a held-out test dataset. A non-linear baseline model improved the PVEs from 28.1 to 30.1% (SBP) and 14.3% to 17.4% (DBP) compared with a linear baseline model. Including seven PRSs in the genetic model computed based on the largest available GWAS of SBP/DBP improved the genetic model PVE from 4.8 to 5.1% (SBP) and 4.7 to 5% (DBP) compared to using a single PRS. Adding additional 14 PRSs computed based on two independent GWASs further increased the genetic model PVE to 6.3% (SBP) and 5.7% (DBP). PVE differed across self-reported race/ethnicity groups, with primarily all non-White groups benefitting from the inclusion of additional PRSs. In summary, non-linear ML models improves BP prediction in models incorporating diverse populations.
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- 2024
296. ECAP-controlled closed-loop versus open-loop SCS for the treatment of chronic pain: 36-month results of the EVOKE blinded randomized clinical trial.
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Mekhail, Nagy, Levy, Robert, Deer, Timothy, Kapural, Leonardo, Li, Sean, Amirdelfan, Kasra, Pope, Jason, Hunter, Corey, Rosen, Steven, Costandi, Shrif, Falowski, Steven, Burgher, Abram, Gilmore, Christopher, Qureshi, Farooq, Staats, Peter, Scowcroft, James, McJunkin, Tory, Carlson, Jonathan, Kim, Christopher, Yang, Michael, Stauss, Thomas, Petersen, Erika, Hagedorn, Jonathan, Rauck, Richard, Kallewaard, Jan, Baranidharan, Ganesan, Taylor, Rod, Poree, Lawrence, Brounstein, Dan, Duarte, Rui, Gmel, Gerrit, Gorman, Robert, Gould, Ian, Hanson, Erin, Karantonis, Dean, Khurram, Abeer, Leitner, Angela, Mugan, Dave, Obradovic, Milan, Ouyang, Zhonghua, Parker, John, Single, Peter, and Soliday, Nicole
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CHRONIC PAIN ,Neuromodulation ,Spinal Cord Stimulation ,Humans ,Male ,Female ,Spinal Cord Stimulation ,Middle Aged ,Chronic Pain ,Treatment Outcome ,Adult ,Aged ,Single-Blind Method ,Pain Measurement ,Time Factors ,Action Potentials ,Quality of Life - Abstract
INTRODUCTION: The evidence for spinal cord stimulation (SCS) has been criticized for the absence of blinded, parallel randomized controlled trials (RCTs) and limited evaluations of the long-term effects of SCS in RCTs. The aim of this study was to determine whether evoked compound action potential (ECAP)-controlled, closed-loop SCS (CL-SCS) is associated with better outcomes when compared with fixed-output, open-loop SCS (OL-SCS) 36 months following implant. METHODS: The EVOKE study was a multicenter, participant-blinded, investigator-blinded, and outcome assessor-blinded, randomized, controlled, parallel-arm clinical trial that compared ECAP-controlled CL-SCS with fixed-output OL-SCS. Participants with chronic, intractable back and leg pain refractory to conservative therapy were enrolled between January 2017 and February 2018, with follow-up through 36 months. The primary outcome was a reduction of at least 50% in overall back and leg pain. Holistic treatment response, a composite outcome including pain intensity, physical and emotional functioning, sleep, and health-related quality of life, and objective neural activation was also assessed. RESULTS: At 36 months, more CL-SCS than OL-SCS participants reported ≥50% reduction (CL-SCS=77.6%, OL-SCS=49.3%; difference: 28.4%, 95% CI 12.8% to 43.9%, p
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- 2024
297. Determinants of mosaic chromosomal alteration fitness.
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Pershad, Yash, Mack, Taralynn, Poisner, Hannah, Jakubek, Yasminka, Stilp, Adrienne, Mitchell, Braxton, Lewis, Joshua, Boerwinkle, Eric, Loos, Ruth, Chami, Nathalie, Wang, Zhe, Barnes, Kathleen, Pankratz, Nathan, Fornage, Myriam, Redline, Susan, Psaty, Bruce, Bis, Joshua, Shojaie, Ali, Silverman, Edwin, Cho, Michael, Yun, Jeong, DeMeo, Dawn, Levy, Daniel, Johnson, Andrew, Mathias, Rasika, Taub, Margaret, Arnett, Donna, North, Kari, Raffield, Laura, Carson, April, Doyle, Margaret, Rich, Stephen, Guo, Xiuqing, Cox, Nancy, Roden, Dan, Franceschini, Nora, Desai, Pinkal, Reiner, Alex, Auer, Paul, Scheet, Paul, Jaiswal, Siddhartha, Weinstock, Joshua, Bick, Alexander, and Rotter, Jerome
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Humans ,Mosaicism ,Chromosome Aberrations ,Clonal Hematopoiesis ,Male ,Female ,Genome-Wide Association Study ,Janus Kinase 2 ,Telomerase ,Loss of Heterozygosity ,Cross-Sectional Studies ,Mutation ,Middle Aged ,Hematopoietic Stem Cells ,Polymorphism ,Single Nucleotide ,Aged - Abstract
Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger structural rearrangements called mosaic chromosomal alterations (mCAs). The factors that influence the variations in mCA fitness and ultimately result in different clonal expansion rates are not well understood. We used the Passenger-Approximated Clonal Expansion Rate (PACER) method to estimate clonal expansion rate as PACER scores for 6,381 individuals in the NHLBI TOPMed cohort with gain, loss, and copy-neutral loss of heterozygosity mCAs. Our mCA fitness estimates, derived by aggregating per-individual PACER scores, were correlated (R2 = 0.49) with an alternative approach that estimated fitness of mCAs in the UK Biobank using population-level distributions of clonal fraction. Among individuals with JAK2 V617F clonal hematopoiesis of indeterminate potential or mCAs affecting the JAK2 gene on chromosome 9, PACER score was strongly correlated with erythrocyte count. In a cross-sectional analysis, genome-wide association study of estimates of mCA expansion rate identified a TCL1A locus variant associated with mCA clonal expansion rate, with suggestive variants in NRIP1 and TERT.
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- 2024
298. The effectiveness of cervical mucus electrical impedance compared to basal body temperature to determine fertility window.
- Author
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Hambright, Sealy, Sikes, Katie, Levy, Gary, Rydfors, Jan, and Tabbaa, Suzanne
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Electrical impedance ,Fertility window ,Ovulation function - Abstract
BACKGROUND: Serial serum hormone measurements and transvaginal ultrasound are reliable measures to predict ovulation. These measures are inconvenient and expensive therefore, basal body temperature charting (BBT) and urine ovulation predictor kits (OPK) for luteinizing hormone are often used to determine the 6-day fertile window. However, BBT does not clearly change until 1-2 days after ovulation. Additionally, while OPK can indicate positivity prior to ovulation, false readings are common. A novel alternative approach involves measuring electrolyte trends in cervical mucus using electrical impedance spectroscopy. Cervical mucus electrolyte measurements are associated with hormone level changes during the menstrual cycle. The purpose of this study was to compare the effectiveness of cervical mucus electrical impedance and basal body temperature. We sought to determine if cervical mucus electrolyte measurements provided improved detection of the ovulation day and therefore, improve fertility timing for women. METHODS: 14 healthy women between 18 and 44 years of age with normal menstrual cycles were enrolled in the Observational Study. Participants measured BBT and cervical mucus electrical impedance daily for 3 menstrual cycles using Kegg (Lady Technologies Inc. San Francisco, California, USA). Ovulation date for each cycle was confirmed by measuring hormone levels in urine and serum, and by vaginal ultrasound. RESULTS: Electrical impedance was significantly different between the follicular phase versus ovulatory date (p = 0.007) and between the luteal phase versus the ovulatory date (p = 0.007). A significant difference in the rate of change of cervical impedance measurements in the pre-ovulatory follicular phase was found compared to BBT (p = 0.0225). The sensitivity (+ 7.14%), specificity (+ 20.35%), and accuracy (+ 17.59) to determine the 1-day fertility window was significantly higher using cervical mucus impedance compared to BBT. CONCLUSIONS: BBT is considered unreliable for evaluating ovulatory function. Cervical mucus electrical impedance offers a novel measure of electrolyte changes associated with hormone levels. We report that pre-ovulatory electrical impedance patterns demonstrated higher sensitivity, specificity, and accuracy for determining the fertility window when compared to BBT. These findings suggest that changes in electrical impedance may provide an accurate method for predicting ovulation and for measuring ovulatory function.
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- 2024
299. The Hopkins-Oxford Psychedelics Ethics (HOPE) Working Group Consensus Statement
- Author
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Jacobs, Edward, Earp, Brian D, Appelbaum, Paul S, Bruce, Lori, Cassidy, Ksenia, Celidwen, Yuria, Cheung, Katherine, Clancy, Sean K, Devenot, Neşe, Evans, Jules, Lynch, Holly Fernandez, Friesen, Phoebe, Romeu, Albert Garcia, Gehani, Neil, Maloof, Molly, Marcus, Olivia, Moen, Ole Martin, Mertens, Mayli, Nayak, Sandeep M, Noorani, Tehseen, Patch, Kyle, Porsdam-Mann, Sebastian, Raj, Gokul, Rajwani, Khaleel, Ray, Keisha, Smith, William, Villiger, Daniel, Levy, Neil, Crisp, Roger, Savulescu, Julian, Singh, Ilina, and Yaden, David B
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Philosophy and Religious Studies ,Health Sciences ,Public Health ,Applied Ethics ,Public Health and Health Services ,Public health ,Applied ethics - Published
- 2024
300. Management of pediatric renal trauma: Results from the American Association for Surgery and Trauma Multi-Institutional Pediatric Acute Renal Trauma Study
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Hwang, Catalina K, Matta, Rano, Woolstenhulme, Jonathan, Britt, Alexandra K, Schaeffer, Anthony J, Zakaluzny, Scott A, Kleber, Kara Teresa, Sheikali, Adam, Flynn-O'Brien, Katherine T, Sandilos, Georgianna, Shimonovich, Shachar, Fox, Nicole, Hess, Alexis B, Zeller, Kristen A, Koberlein, George C, Levy, Brittany E, Draus, John M, Sacks, Marla, Chen, Catherine, Luo-Owen, Xian, Stephens, Jacob Robert, Shah, Mit, Burks, Frank, Moses, Rachel A, Rezaee, Michael E, Vemulakonda, Vijaya M, Halstead, N Valeska, LaCouture, Hunter M, Nabavizadeh, Behnam, Copp, Hillary, Breyer, Benjamin, Schwartz, Ian, Feia, Kendall, Pagliara, Travis, Shi, Jennifer, Neuville, Paul, and Hagedorn, Judith C
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Biomedical and Clinical Sciences ,Clinical Sciences ,Kidney Disease ,Pediatric ,Physical Injury - Accidents and Adverse Effects ,7.3 Management and decision making ,Injuries and accidents ,Humans ,Male ,Female ,Child ,Retrospective Studies ,United States ,Kidney ,Injury Severity Score ,Trauma Centers ,Adolescent ,Wounds ,Nonpenetrating ,Child ,Preschool ,Infant ,Multi-institutional ,pediatric trauma ,renal trauma ,trauma centers ,conservative management ,Clinical sciences ,Nursing - Abstract
BackgroundPediatric renal trauma is rare and lacks sufficient population-specific data to generate evidence-based management guidelines. A nonoperative approach is preferred and has been shown to be safe. However, bleeding risk assessment and management of collecting system injury are not well understood. We introduce the Multi-institutional Pediatric Acute Renal Trauma Study (Mi-PARTS), a retrospective cohort study designed to address these questions. This article describes the demographics and contemporary management of pediatric renal trauma at Level I trauma centers in the United States.MethodsRetrospective data were collected at 13 participating Level I trauma centers on pediatric patients presenting with renal trauma between 2010 and 2019. Data were gathered on demographics, injury characteristics, management, and short-term outcomes. Descriptive statistics were used to report on demographics, acute management, and outcomes.ResultsIn total, 1,216 cases were included in this study. Of all patients, 67.2% were male, and 93.8% had a blunt injury mechanism. In addition, 29.3% had isolated renal injuries, and 65.6% were high-grade (American Association for the Surgery of Trauma Grades III-V) injuries. The mean Injury Severity Score was 20.5. Most patients were managed nonoperatively (86.4%), and 3.9% had an open surgical intervention, including 2.7% having nephrectomy. Angioembolization was performed in 0.9%. Collecting system intervention was performed in 7.9%. Overall mortality was 3.3% and was only observed in patients with multiple injuries. The rate of avoidable transfer was 28.2%.ConclusionThe management and outcomes of pediatric renal trauma lack data to inform evidence-based guidelines. Nonoperative management of bleeding following renal injury is a well-established practice. Intervention for renal trauma is rare. Our findings reinforce differences from the adult population and highlights opportunities for further investigation. With data made available through Mi-PARTS, we aimed to answer pediatric specific questions, including a pediatric-specific bleeding risk nomogram, and better understanding indications for interventions for collecting system injuries.Level of evidencePrognostic and Epidemiological; Level IV.
- Published
- 2024
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