1,478 results on '"M. Fahmy"'
Search Results
252. Image compression using block pattern-vector quantization with variable codevector dimensions.
- Author
-
Sherif A. Mohamed and Moustafa M. Fahmy
- Published
- 1992
- Full Text
- View/download PDF
253. On the multivariate distributions of order statistics of discrete-state processes.
- Author
-
Don M. Raymond and Moustafa M. Fahmy
- Published
- 1991
- Full Text
- View/download PDF
254. Optimal M-D sorting using distributions of order statistics.
- Author
-
Don M. Raymond and Moustafa M. Fahmy
- Published
- 1991
- Full Text
- View/download PDF
255. NMR Signal Enhancement Via a New Time-Frequency Transform.
- Author
-
Osama A. Ahmed and Moustafa M. Fahmy
- Published
- 2001
- Full Text
- View/download PDF
256. ACCEPTANCE OF COVID-19 VACCINES AMONG NURSES
- Author
-
F, Elmetwaly, primary, M, Fahmy, additional, A, El-Gilany, additional, S, Bauomy, additional, and N, Taref, additional
- Published
- 2022
- Full Text
- View/download PDF
257. Green Synthesis of Zinc Oxide Nanoparticles (ZnO-NPs) by
- Author
-
Abdullah M, Abdo, Amr, Fouda, Ahmed M, Eid, Nayer M, Fahmy, Ahmed M, Elsayed, Ahmed Mohamed Aly, Khalil, Othman M, Alzahrani, Atef F, Ahmed, and Amal M, Soliman
- Subjects
ZnO-NPs ,larvicidal activity ,antimicrobial activity ,green synthesis ,Pseudomonas aeruginosa ,Article - Abstract
The synthesis of nanoparticles by green approaches is gaining unique importance due to its low cost, biocompatibility, high productivity, and purity, and being environmentally friendly. Herein, biomass filtrate of Pseudomonas aeruginosa isolated from mangrove rhizosphere sediment was used for the biosynthesis of zinc oxide nanoparticles (ZnO-NPs). The bacterial isolate was identified based on morphological, physiological, and 16S rRNA. The bio-fabricated ZnO-NPs were characterized using color change, UV-visible spectroscopy, FT-IR, TEM, and XRD analyses. In the current study, spherical and crystalline nature ZnO-NPs were successfully formed at a maximum SPR (surface plasmon resonance) of 380 nm. The bioactivities of fabricated ZnO-NPs including antibacterial, anti-candida, and larvicidal efficacy were investigated. Data analysis showed that these bioactivities were concentration-dependent. The green-synthesized ZnO-NPs exhibited high efficacy against pathogenic Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), and unicellular fungi (Candida albicans) with inhibition zones of (12.33 ± 0.9 and 29.3 ± 0.3 mm), (19.3 ± 0.3 and 11.7 ± 0.3 mm), and (22.3 ± 0.3 mm), respectively, at 200 ppm. The MIC value was detected as 50 ppm for E. coli, B. subtilis, and C. albicans, and 200 ppm for S. aureus and P. aeruginosa with zones of inhibition ranging between 11.7 ± 0.3–14.6 ± 0.6 mm. Moreover, the biosynthesized ZnO-NPs showed high mortality for Culex pipiens with percentages of 100 ± 0.0% at 200 ppm after 24 h as compared with zinc acetate (44.3 ± 3.3%) at the same concentration and the same time.
- Published
- 2021
258. Potential Nutritional Value of the Macrophyte Vossia cuspidata (Roxb.) Griff. (Poaceae) in a River Nile System, Egypt
- Author
-
Emad A. Farahat, Waleed F. Mahmoud, Gamal M. Fahmy, Hussein F. Farrag, and Hossam E.A. Awad
- Subjects
Ecology ,Forage ,Cell Biology ,Plant Science ,Beef cattle ,Biology ,Macrophyte ,chemistry.chemical_compound ,Animal science ,chemistry ,Aquatic plant ,Genetics ,Dry matter ,Hemicellulose ,Poaceae ,Water content ,Ecology, Evolution, Behavior and Systematics ,Biotechnology - Abstract
AQUATIC plants are of real interest for their nutritive value. The present study aimed at investigating the forage potentiality of the aquatic macrophyte Vossia cuspidata (Roxb.) Griff (Poaceae). Two islands in the River Nile system in Greater Cairo, Egypt were selected for sampling the leaf laminae from V. cuspidata in eighteen quadrates (0.5x 0.5m each) during February (winter), and August (summer) of 2017. The chemical analyses revealed that there were no significant differences between the contents of summer and winter leaves in their percentages of moisture, dry matter, ash, nitrogen-free extract, neutral detergent fibers, acid detergent fibers, acid detergent lignin, cellulose, and hemicellulose. The leaves were characterized by a high percentage of dry matter (DM, ≈ 92%), low moisture content (7.94-7.27% DM), high crude fibers (24.1-38.2%DM), moderate crude protein (7.2=19.2%), and low lipids content (1.7-2.0% DM). The plant is rich in many important elements (K, Ca, P, Cu, and Zn). The ratio of Ca/P (= 2.43) is within the adequate range for animal forage. The other parameters of the nutritive values of the leaves and their importance to animal feeding were discussed. The leaves of V. cuspidata are recommended as good forage for beef cattle and lactating cows.
- Published
- 2021
- Full Text
- View/download PDF
259. Association of Hydroxy (Steroid) Dehydrogenase 11b1 Gene with Type 2 Diabetes Mellitus in Egyptian Population
- Author
-
Eman M. Fahmy, Raef Malak Botros, Salah H Halawani, Laila M Hendawy, and Alaa Tarek Younis
- Subjects
chemistry.chemical_classification ,medicine.medical_specialty ,education.field_of_study ,business.industry ,Population ,Type 2 Diabetes Mellitus ,Single-nucleotide polymorphism ,General Medicine ,Steroid dehydrogenase ,Endocrinology ,chemistry ,Oxidoreductase ,Polymorphism (computer science) ,Internal medicine ,Medicine ,business ,education ,Gene - Abstract
Background Type 2 diabetes mellitus is a heterogeneous group of metabolic disorders caused by the interaction between genetic predisposition and environmental factors. The incidence of type 2 diabetes mellitus has increased over the last decades with more than 170 million individuals suffering from type 2 diabetes mellitus all over the world which imposes a greater economic impact on individuals, families and health systems. Though the genetic susceptibility to type 2 diabetes mellitus is polygenic, single nucleotide polymorphisms (SNP) at Hydroxy steroid dehydrogenase (HSD11B1) gene have been strongly associated with type 2 diabetes risk in various populations and ethnic groups. Objectives The aim of this study is to assess the association of Hydroxy-Steroid-Dehydrogenase-11B1 gene (rs846910) with type 2 diabetes mellitus in a sample of Egyptian population. Patients and Methods In the present study, we included 60 diabetic obese patients and 40 age and sex-matched controls. The mean age of the included patients was 50.26 ±9.1 year; while the majority of them were females (70%). All the participating patients were subjected to detailed history and the following investigations: fasting blood sugar, post prandial sugar,HbA1c, and lipid profile. Detection of gene polymorphism by real time PCR was performed for all subjects in the study. Results The study showed that homozygous GG genotype was more prelevant than GA genotype. No significant difference between GG and GA in terms of fasting and postprandial sugar and in terms of lipid profile: cholesterol (p = 0.642), TG (p = 0.808), LDL (p = 0.238), and HDL (p = 0.945).It showed no statistically significant difference between cases and controls in terms of HSD11B1 polymorphism (rs846910). The regression analysis showed that the HSD11B1 polymorphism did not significantly increase the risk of diabetes mellitus (OR 1.724, 95% CI [0.601 – 4.94]). Conclusion In conclusion, multiple further studies involving other single nucleotide polymorphism of 11 beta hydroxysteroid dehydrogenase gene as well as other genes involved in type 2 diabetes mellitus and obesity need to be done.
- Published
- 2021
- Full Text
- View/download PDF
260. Thyme Oil and Thymol Counter Doxorubicin-Induced Hepatotoxicity
- Author
-
Osama M, Ahmed, Sanaa R, Galaly, Mennah-Allah M A, Mostafa, Emad M, Eed, Tarek M, Ali, Alzhraa M, Fahmy, and Mohamed Y, Zaky
- Subjects
Inflammation ,Male ,Liver Diseases ,Apoptosis ,Thymol ,Rats ,Thymus Plant ,Oxidative Stress ,Doxorubicin ,Oils, Volatile ,Animals ,Humans ,Plant Oils ,Chemical and Drug Induced Liver Injury ,Rats, Wistar - Abstract
Doxorubicin (DOX) is an effective anticancer agent with a wide spectrum of activities. However, it has many adverse effects on various organs especially on the liver. Thymol, one of the major components of thyme oil, has biological properties that include anti-inflammatory and antioxidant activities. Thus, this study was designed to examine thyme oil and thymol for their ability to prevent doxorubicin-induced hepatotoxicity in Wistar rats. Hepatotoxicity was induced by an intraperitoneal injection of doxorubicin, at a dose of 2 mg/kg bw/week, for seven weeks. Doxorubicin-injected rats were supplemented with thyme oil and thymol at doses 250 and 100 mg/kg bw, respectively, four times/week by oral gavage for the same period. Treatment of rats with thyme oil and thymol reversed the high serum activities of AST, ALT, and ALP and total bilirubin, AFP, and CA19.9 levels, caused by doxorubicin. Thyme oil and thymol also reduced the high levels of TNF
- Published
- 2021
261. MinkowRadon: Multi-Object Tracking Using Radon Transformation and Minkowski Distance
- Author
-
Omar M. Fahmy, Khaled Ezzat, and Mustafa Elattar
- Subjects
Transformation (function) ,Computer science ,business.industry ,Deep learning ,Video tracking ,Stability (learning theory) ,Minkowski distance ,Computer vision ,Artificial intelligence ,Performance improvement ,Tracking (particle physics) ,business ,Thresholding - Abstract
The latest trend in multiple object tracking (MOT) is bending to utilize deep learning to improve tracking performance. With all advanced models such as R-CNN, YOLO, SSD, and RetinaNet, there will always be a time-accuracy trade-off which puts constraints to computer vision advancement. However, it is not trivial to solve those kinds of challenges using end-to-end deep learning models, adopting new strategies to enhance the aforementioned models are appreciated. In this paper we introduce a novel radon transformation based framework, which takes advantage of color space conversion and squeezes the MOT problem to signal domain using radon transformation. Afterwards, the inference of Minkowski distance between sequence of signals is used to estimate the objects' location. Adaptive Region of Interest (ROI) and thresholding criteria have been adopted to ensure the stability of the tracker. We experimentally demonstrated that the proposed method achieved a significant performance improvement in both The Multiple Object Tracking Accuracy (MOTA) and ID F1 (IDF1) with respect to previous state-of-the-art using two public benchmarks.
- Published
- 2021
- Full Text
- View/download PDF
262. Prediction Models for Evaluating the Uptake of Heavy Metals by the Invasive Grass Vossia cuspidata (Roxb.) Griff. in the River Nile, Egypt: A Biomonitoring Approach
- Author
-
Muhammad Arshad, Gamal M. Fahmy, Hussein F. Farrag, Ebrahem M. Eid, Emad A. Farahat, Waleed F. Mahmoud, and Hossam E.A. Awad
- Subjects
Geography, Planning and Development ,TJ807-830 ,Bioconcentration ,phytoremediation ,Management, Monitoring, Policy and Law ,Silt ,TD194-195 ,Renewable energy sources ,Biomonitoring ,bioindicator ,Organic matter ,GE1-350 ,heavy metals ,chemistry.chemical_classification ,water pollution ,Environmental effects of industries and plants ,Renewable Energy, Sustainability and the Environment ,Chemistry ,Sediment ,prediction models ,Rhizome ,Environmental sciences ,Phytoremediation ,Environmental chemistry ,hippo grass ,Bioindicator - Abstract
This study aimed to develop new prediction models that include sediment properties (pH, organic matter, and silt and clay concentrations) for estimating the potential uptake of heavy metals (HMs) by the invasive grass Vossia cuspidata. Plant and sediment samples were collected from the microsites that represent the natural distribution of the species in two Nile islands in Cairo, Egypt. The results show that the root was the main accumulating organ for the analyzed HMs (Fe, Mn, Zn, Cu, Ni, and Pb). The mean concentrations of Fe and Mn and the maximum concentrations of Cu, Ni, and Pb were phytotoxic. The values of the bioconcentration factor were >, 1, while the translocation factor was >, 1 for Zn and Cu in rhizome and stem, Mn in leaf, and Ni and Pb in stem and leaf. There were no significant differences between the measured and the predicted HM concentrations in all organs of the species. This indicates the excellent robustness of the developed regression models. Sixteen equations (out of 24) had high R2 values. Thus, V. cuspidata could be considered a biomonitor for HM pollution, and the developed equations will benefit the prediction of HM uptake by the species in the River Nile ecosystem.
- Published
- 2021
- Full Text
- View/download PDF
263. Chemically/Electrically-Assisted Regeneration of Polyacrylonitrile-based Hydrogel adsorbed Heavy Metals
- Author
-
Amany El Mansoub, Marwa M. El Sayed, Hussein M. Fahmy, Abdelghany M.G. Abulnour, and Rasha M. El Nashar
- Subjects
Materials science ,technology, industry, and agriculture ,Polyacrylonitrile ,chemistry.chemical_element ,Chromium ,chemistry.chemical_compound ,Nickel ,Adsorption ,chemistry ,Chemical engineering ,Desorption ,Freundlich equation ,Fourier transform infrared spectroscopy ,Porosity - Abstract
Adsorption is an important technology for the removal of heavy metals from industrial effluents. Efficient regeneration of exhausted adsorbents is essential for improving the applicability of different adsorbents. In this work an adsorptive polyacrylonitrile-based hydrogel was characterized and investigated in terms of adsorption/regeneration using both conventional chemical and electrical-assisted regeneration techniques. The hydrogel characterization includes FTIR, XRD, SEM, EDAX, porosity, and electrical conductivity. Hydrogel performance in adsorption and conventional chemical regeneration was tested. Further, electrically-assisted regeneration using a special design cell was also investigated. The maximum adsorption capacities for chromium and nickel were 8.082, and 17.437 mg/g, respectively. The isotherm data fitted Freundlich, while kinetic data fitted pseudo-second-order model. Conventional chemical desorption showed regeneration efficiency of 15.58, and 27.27 % for chromium and nickel, respectively. While, the electrically-assisted regeneration showed much higher values of 51.6, and 98.3 % for chromium and nickel, respectively indicating the merit of using electrically-assisted chemical regeneration for enhancing heavy metals adsorbing hydrogel applicability.
- Published
- 2021
- Full Text
- View/download PDF
264. The influence of low- intensity laser irradiation versus hyperbaric oxygen therapy on transcutaneous oxygen tension in chronic diabetic foot ulcers: a controlled randomized trial
- Author
-
Ibrahim H. Aboughaleb, Ayman A. Nassar, Mohamed Hisham Aref, Siham M. Fahmy, and Amir N. Wadee
- Subjects
business.industry ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,medicine.disease ,Diabetic foot ,law.invention ,Diabetic foot ulcer ,Randomized controlled trial ,law ,Diabetes mellitus ,Anesthesia ,Internal Medicine ,medicine ,Low-intensity laser ,Transcutaneous oxygen ,business ,Saline ,Bandage ,Research Article - Abstract
BACKGROUND AND OBJECTIVE: Evaluation of the stage and severity of the chronic diabetic foot ulcer (CDFU) is vital to increase the healing rate and to select the suitable treatment. We aim to assess the influence of low-intensity laser irradiation (LILI) and hyperbaric oxygenation therapy (HBOT) to accelerate the CDFU healing thru the transcutaneous oxygen tension (TcPO2) measurements. MATERIALS AND METHODS: Seventy-five diabetic patients (type 2) of both genders, their ages ranged from 40–65 years with CDFUs (duration of ulcer
- Published
- 2021
265. A new method for designing M-D linear-phase FIR digital filters using the WKS sampling theory.
- Author
-
Ahmad A. Masoud and Moustafa M. Fahmy
- Published
- 1990
- Full Text
- View/download PDF
266. Inverse of linear periodically time-varying filtering.
- Author
-
Heping Ding and Moustafa M. Fahmy
- Published
- 1990
- Full Text
- View/download PDF
267. Evaluation of ketamine versus midazolam as co-induction agents with propofol for laryngeal mask airway insertion in children
- Author
-
Amany K. Aboelhussein, Wegdan A. Ali, and Marwa M. Fahmy
- Subjects
business.industry ,030208 emergency & critical care medicine ,Laryngeal mask airway insertion ,03 medical and health sciences ,0302 clinical medicine ,Anesthesiology and Pain Medicine ,Laryngeal mask airway ,030202 anesthesiology ,Anesthesia ,Medicine ,Midazolam ,Ketamine ,business ,Propofol ,medicine.drug - Abstract
The ideal combination of adjuncts with induction agents for Laryngeal mask airway (LMA) insertion is a matter of debate, particularly in children. To comparatively evaluate LMA insertion using keta...
- Published
- 2020
- Full Text
- View/download PDF
268. Functional Finishing of Polyester Fabric Using Bentonite Nano-Particles
- Author
-
Amira Abou El-Kheir, Nahed A. Abd El-Ghany, Lamiaa Kamal El-Gabry, Sara Aboras, and Mona M. Fahmy
- Subjects
010407 polymers ,Thermogravimetric analysis ,Materials science ,technology, industry, and agriculture ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Polyester ,Transmission electron microscopy ,parasitic diseases ,Bentonite ,Ultimate tensile strength ,Dyeing ,Fourier transform infrared spectroscopy ,Composite material ,0210 nano-technology ,Curing (chemistry) - Abstract
This work is devoted to increase the functional properties of polyester fabric such as UPF, moisture regain, tensile strength at break and dyeability towards basic dye. To achieve this purpose polyester fabric were modified with different concentrations bentonite nano-particles (BNPs) using pad – dry curing technique and IR dyeing machine. The effect of the (BNPs) on the physical and mechanical properties of the treated fabrics such as moisture regain, tensile strength at break, elongation percentage and thickness were investigated. Topographical investigation of the said nano-particles was conducted using transmission electron microscopy (TEM). The surface morphology and surface chemical elements of the treated as well as the untreated fabrics were investigated using field emission scanning electron microscopy and dispersive X-ray spectroscopy, respectively. FTIR, thermogravimetric analysis and UPF of the treated polyester fabrics compared to the untreated one were assessed. The colour strength of dyed polyester fabrics with both disperse and cationic dyestuffs as well as the fastness properties were evaluated. Excellent results of the treated fabrics toward physical and coloration properties were obtained.
- Published
- 2020
- Full Text
- View/download PDF
269. Nurses' Knowledge and Practices Regarding Oxytocin Infusion Care for Women during Labor
- Author
-
Somaya Ouda Abd-Elmoniem, Eman Samy Sengab, Nadia M. Fahmy, and Aziza Ibrahim Mohammed
- Subjects
Research design ,Nursing ,Interview ,Oxytocin ,business.industry ,Nurses knowledge ,Infusion care ,Medicine ,Observational study ,Positive correlation ,business ,Checklist ,medicine.drug - Abstract
Background: Oxytocic are the drugs that give power to excite uterine muscles to contract. Betweena large numbers of drugs belonging to oxytocic, oxytocin is the important one and is extensivelyused in clinical practice. Aim of the study: To assess nurses' knowledge and practice regardingoxytocin infusion care for women during labor. Research design: A descriptive study wasconducted. Setting: The study was conducted in labor unit at obstetrics and gynecologicaldepartment affiliated at Benha University hospital from the end of May to the end of November2017. Sample: Convenient sample of a total nurses 50. Tool: Two tools were utilized to collectdata; Tool (I): structure interviewing questionnaire divided in two parts including generalcharacteristics of nurse and assessment knowledge sheet for assessing nurses’ knowledge regardingoxytocin. Tool (II): an observational checklist to assess nurses' practices during oxytocin infusion.Result: Near half (44%) of the studied nurses had poor knowledge and two thirds (60%) of themhad unsatisfactory practice regarding oxytocin infusion care. Conclusion: Half of studied nurseshad poor knowledge and unsatisfactory practice and there was a positive correlation between totalknowledge and practice score of studied nurses. Recommendation: Improve nurses' knowledgeand practice regarding oxytocin and its safe administration.
- Published
- 2020
- Full Text
- View/download PDF
270. HIGH Q-FACTOR BANDSTOP FILTER BASED ON CPW RESONATOR BROADSIDE-COUPLED TO CPW THROUGH-LINE
- Author
-
and Abd-El-Hadi A. Ammar, Khalid Fawzy Ahmed Hussein, Asmaa E. Farahat, and Walid M. Fahmy
- Subjects
Resonator ,Materials science ,Optics ,business.industry ,Q factor ,Electrical and Electronic Engineering ,Line (text file) ,Condensed Matter Physics ,Band-stop filter ,business ,Electronic, Optical and Magnetic Materials ,Broadside - Published
- 2020
- Full Text
- View/download PDF
271. Evaluationof efficacy of noninvasive ventilation in acute hypoxemic respiratory failure
- Author
-
Mahmoud M Elbataony, Doaa Rashwan, Noha M Fahmy, Nabila Ibrahim Laz, and Abeer S Mohamed
- Subjects
lcsh:RC705-779 ,ARDS ,Respiratory rate ,APACHE II ,business.industry ,medicine.medical_treatment ,acute hypoxemic respiratory failure ,General Engineering ,noninvasive ventilation ,lcsh:Diseases of the respiratory system ,medicine.disease ,SAPS II ,predictors of failure of noninvasive ventilation ,Oxygen therapy ,Anesthesia ,medicine ,General Earth and Planetary Sciences ,Intubation ,Respiratory system ,Complication ,business ,General Environmental Science - Abstract
Objective The role of noninvasive ventilation (NIV) in patients with acute respiratory failure is uncertain, so we conducted an observational trial of NIV comparing it with standard oxygen therapy in 109 patients with acute hypoxemic respiratory failure to detect the outcomes of NIV and the factors associated with NIV failure. Patients and methods All patients requiring NIV from March 2017 to September 2018 in respiratory ICU were entered into the study. The authors reported the etiology of acute hypoxemic respiratory failure (AHRF) and data were collected for heart rate, respiratory rate, and arterial blood gases (pH, PaO2, PaCO2). The patients were divided into group I standard oxygen therapy, group II NIV, and again group II was divided into group IIa, patients who avoid intubation and group II b, patients who need intubation. Results Simplified acute physiologic score (SAPS II) and acute physiologic and chroic health evaluation (APACHE) scores and mortality were higher in the VIN group but intubation rate, ICU, and hospital stay were higher in the oxygen group. Factors that were associated with failure of NIV were underlying immunosuppression, acute respiratory distress syndrome (ARDS) as a cause of AHRF, underlying malignancy, high SAPS II greater than 33 and APACHE II score of more than 25 and baseline PO2/FiO2 less than 211. Conclusion NIV was effective than oxygen therapy in the management of AHRF regarding intubation rate, complication, ICU, and hospital stay but mortality was higher in the NIV group may be because of severe cases. Factors associated with failure of NIV were immunosuppression, malignancy, ARDS, high SAPS II more than 33 and APACHE II more than 25 score and baseline PO2/FiO2 less than 211.
- Published
- 2020
272. Detection and Characterization of Botrytis cinerea Isolates from Vegetables in Egypt
- Author
-
Hala Abdel Wahab, Elsayed E. Wagih, Magda M. Fahmy, Mahmoud A. Gaber, and Mohamed R. A. Shehata
- Subjects
0106 biological sciences ,0301 basic medicine ,Veterinary medicine ,food.ingredient ,biology ,fungi ,food and beverages ,Virulence ,Molecular variation ,Plant Science ,Vegetable crops ,biology.organism_classification ,01 natural sciences ,Agricultural and Biological Sciences (miscellaneous) ,Crop ,03 medical and health sciences ,030104 developmental biology ,food ,Pepper ,Correlation analysis ,Agronomy and Crop Science ,010606 plant biology & botany ,Botrytis cinerea ,Botrytis - Abstract
Botrytis cinerea is a necrotrophic plant pathogen that causes plenty of crop losses in Egypt and worldwide. Fifteen isolates of B. cinerea were collected from cabbage, pepper and lettuce grown in different locations in Egypt and subjected to investigation. Diversity in phenotypic, pathological and molecular characteristics was detected among isolates, leading to categorising them into four different groups. Molecular variation was demonstrated in all isolates by transposable elements (TEs) analyses. Four TE types, based on the presence or absence of two transposable elements, boty and flipper, were recognised among B. cinerea isolates in which transposa type (having both TE, boty + flipper) was predominant (40%), while only boty and only flipper types appeared with distribution values of 26.7 and 20%, respectively and vacuma type (Lacking both TEs) showed the lowest distribution value (13.3%). Furthermore, vacuma population demonstrated the lowest potential comparing to others. A correlation was found between TE type and virulence level of isolate, but no impact of TE type was observed on phenotypic characteristics of B. cinerea. The present study revealed a correlation between the TE type and the isolate virulence, but no correlation was observed between phenotypic characteristic/sensitivity to fenhexamid and TE type
- Published
- 2019
- Full Text
- View/download PDF
273. Oxidative Impact of Carob Leaf Extract–Synthesized Iron Oxide Magnetic Nanoparticles on the Kidney, Liver, Testis, and Spleen of Wistar Rats
- Author
-
Heba M. Fahmy
- Subjects
Antioxidant ,medicine.medical_treatment ,Biomedical Engineering ,Iron oxide ,Nanoparticle ,Bioengineering ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,medicine.disease_cause ,01 natural sciences ,0104 chemical sciences ,Nanomaterials ,chemistry.chemical_compound ,chemistry ,medicine ,Magnetic nanoparticles ,0210 nano-technology ,Hybrid material ,Iron oxide nanoparticles ,Oxidative stress ,Nuclear chemistry - Abstract
“Eco” synthesis has become a reliable, sustainable, and ecological protocol in the field of material science, which has given great attention to synthesizing a wide range of material/nanomaterials, such as nanomaterials, hybrid materials, and bio-inspired metal-metal oxides. Green synthesis is therefore considered an important tool for reducing the destructive effects of traditional nanoparticle syntheses commonly used in laboratory and industry. The aim of the present study was to investigate the effect of carob leaf–synthesis magnetic iron oxide nanoparticles on the oxidative status of the liver, kidney, spleen, and testis of male Wistar rats. The green synthesized nanoparticles were characterized through transmission electron microscopy, dynamic light scattering, and atomic force microscopy. The green-synthesized magnetite nanoparticles had 16 ± 2.4 nm average diameter and were monodispersed. The prepared nanoparticles did not cause oxidative stress damage in the tested organs, and this is mainly due to the strong antioxidant power of the carob leaf extract used in their synthesis. Carob leaf–synthesized nanoparticles prepared in the present study are highly safe which make them suitable to be used in many biological and medical applications.
- Published
- 2019
- Full Text
- View/download PDF
274. Studies on Botrytis spp. Infected Ornamental Plants and Emergence of Resistant Isolates Against Fenhexamid in Egypt
- Author
-
Hala Abdel Wahab, Magda M. Fahmy, Mahmoud A. Gaber, Mohamed R. A. Shehata, and Elsayed E. Wagih
- Subjects
Horticulture ,food.ingredient ,food ,Ornamental plant ,Plant Science ,Biology ,Agronomy and Crop Science ,Botrytis - Published
- 2019
- Full Text
- View/download PDF
275. Cellulase Production by Fusarium graminearum and its Application in Ruminant’s Diets Degradation
- Author
-
Hoda Alzahar, H. H. Azzaz, A.A. Aboamer, M. Fahmy, and H.A. Murad
- Subjects
Dietary Fiber ,Rumen ,Cellulase ,Total mixed ration ,Zea mays ,Eating ,chemistry.chemical_compound ,Fusarium ,Ruminant ,Animals ,Lactation ,Hemicellulose ,Dry matter ,Food science ,Cellulose ,Silage ,biology ,Chemistry ,Ruminants ,biology.organism_classification ,Animal Feed ,Diet ,Neutral Detergent Fiber ,Milk ,Corn stover ,Fermentation ,biology.protein ,Digestion ,Female ,Agronomy and Crop Science - Abstract
Background and objective Cellulase as a fibrolytic enzyme is a highly effective tool for agricultural waste treatments. Production of cellulase enzyme on medium of agricultural wastes by Fusarium graminearum to be used in ruminant feeding was the main objective of this study. Materials and methods Impact of initial pH of growth medium, different nitrogen sources and variety of agriculture by products as a carbon sources on cellulase production have been studied. Electron microscope was used for investigate the impact of the resultant cellulase on corn stover degradation, while batch culture technique was used for investigate impact of different levels of the produced and commercial cellulases on total mixed ration digestibility by rumen microorganisms (in vitro). Results Cellulase maximum production by F. graminearum was obtained at 20% corn stover, initial pH of growth medium 5.0 and peptone as a nitrogen source. All addition levels of the produced cellulase increased dry matter (DM), neutral detergent fiber (NDF), acid detergent fiber (ADF), cellulose and hemicellulose degradability of the treated diets, but the maximum produced cellulase efficiency% for dry matter degradability was obtained at 1200 IU kg-1 DM reached 23.19% over the control. Conclusion Utilization of the produced cellulase in enrichment of the feeding value of the agricultural by-products may help in overcome of the feed gap with good impact on environment and public health.
- Published
- 2019
- Full Text
- View/download PDF
276. Pectinase Production Optimization for Improving Dairy Animal’s Diets Degradation
- Author
-
Noha A. Hassaan, H. H. Azzaz, M. Fahmy, and H.A. Murad
- Subjects
Food Animals ,Chemistry ,Production optimization ,Degradation (geology) ,Animal Science and Zoology ,Food science ,Pectinase - Published
- 2019
- Full Text
- View/download PDF
277. Carbetocin versus rectal misoprostol for management of third stage of labor among women with low risk of postpartum hemorrhage
- Author
-
Hala Nabil, Noha M. Salah, Aimy Essam, Amira S. Dieb, Eman A. Hussein, Radwa M Fahmy, M. A. Waly, and Ahmed M. Maged
- Subjects
Adult ,medicine.medical_specialty ,Randomization ,Administration, Oral ,Uterotonic ,Oxytocin ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Administration, Rectal ,Pregnancy ,law ,Oxytocics ,medicine ,Humans ,030212 general & internal medicine ,Adverse effect ,Misoprostol ,030219 obstetrics & reproductive medicine ,Vaginal delivery ,Obstetrics ,business.industry ,Postpartum Hemorrhage ,Obstetrics and Gynecology ,General Medicine ,medicine.disease ,Uterine atony ,Egypt ,Female ,Carbetocin ,business ,Labor Stage, Third ,medicine.drug - Abstract
OBJECTIVE To compare effectiveness and safety of carbetocin and misoprostol for prevention of postpartum hemorrhage (PPH) among low-risk women. METHODS Randomized controlled trial among 150 pregnant women with low risk of PPH admitted for vaginal delivery at Kasr Al Ainy Hospital, Cairo, Egypt, between July 2018 and May 2019. Participants were assigned to two groups by a web-based randomization system ensuring allocation concealment. After neonatal delivery, the carbetocin group received one ampoule of carbetocin (100 μg/mL) intravenously and the misoprostol group received two rectal tablets of misoprostol (800 μg) for active management of the third stage. Blood pressure, blood loss, and hemoglobin levels were monitored. The primary outcome measure was need for additional uterotonic drugs. RESULTS The carbetocin group had significantly less blood loss (P
- Published
- 2019
- Full Text
- View/download PDF
278. Antimicrobial Activity of Marine Actinomycetes and the Optimization of Culture Conditions for the Production of Antimicrobial Agent(s)
- Author
-
Lamis Sh. Abdelfattah, Moaz M. Hamed, and Nayer M. Fahmy
- Subjects
actinomycetes ,antimicrobial ,marine sediment ,Food science ,Biology ,Antimicrobial ,Applied Microbiology and Biotechnology ,optimization ,Microbiology ,QR1-502 ,Biotechnology - Abstract
The aim of the present study was to isolate antagonistic actinomycetes from marine sediment collected from the Red Sea coast at Hurghada city and the Suez Gulf. A total of 16 actinomycete isolates were obtained in October 2018 and their antagonistic activities were evaluated against Aeromonas hydrophila, Vibrio damsela, Staphylococcus aureus ATCC6538, Bacillus subtilis ATCC 6633, Pseudomonas aeruginosa ATCC 9027, Salmonella typhimurium ATCC 14028, Escherichia coli ATCC 19404 and Candida albicans ATCC 10231 by using the agar well diffusion method. Among the 16 isolates, 14 (87.5%) isolates exhibited antimicrobial activity against most of the tested pathogens. The most potent isolate was identified by 16S rRNA sequence analysis as Streptomyces sp. and designated Streptomyces sp. MK388207. The experimental design of Plackett-Burman was implemented to optimize the culture conditions for antimicrobial agent(s) production by the most powerful isolate against C. albicans ATCC 10231 when grown in starch nitrate broth and the data revealed that negative (–) levels of KNO3, K2HPO4 and pH and positive (+) levels of starch, MgSO4.7H2O, FeSO4 and incubation period supported the production of the antimicrobial agent(s). Growth under the optimized culture conditions led to a 1.4-fold rise in antimicrobial activity. The ethyl acetate extract of Streptomyces sp.MK388207 was subjected to gas-liquid chromatography mass spectrometry (GC MS) and revealed the presence of six fractions with the major component being phenol, 2,4-bis (1,1 dimethylethyl). The findings of this study suggested that the antagonistic marine Streptomyces, in particular Streptomyces sp MK388207, the antibacterial compounds produced by this isolate, could be used as antibiotics that could have future applications in the pharmaceutical industry.
- Published
- 2019
279. Rebalancing Immune Homeostasis to Treat Autoimmune Diseases
- Author
-
Antonio La Cava, Tarek M. Fahmy, David A. Horwitz, Ciriaco A. Piccirillo, Horwitz, D. A., Fahmy, T. M., Piccirillo, C. A., and La Cava, A.
- Subjects
0301 basic medicine ,T-Lymphocytes ,medicine.medical_treatment ,Immunology ,Autoimmunity ,autoimmune disease ,chemical and pharmacologic phenomena ,Inflammation ,medicine.disease_cause ,Article ,Autoimmune Diseases ,Immune tolerance ,Proinflammatory cytokine ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Immunity ,medicine ,Animals ,Homeostasis ,Humans ,Immunology and Allergy ,Effector ,business.industry ,immune regulation ,Dendritic Cells ,Immunotherapy ,3. Good health ,030104 developmental biology ,nanoparticles ,immunotherapy ,medicine.symptom ,business ,030215 immunology - Abstract
During homeostasis, interactions between tolerogenic dendritic cells (DCs), self-reactive T cells, and T regulatory cells (Tregs) contribute to maintaining mammalian immune tolerance. In response to infection, immunogenic DCs promote the generation of proinflammatory effector T cell subsets. When complex homeostatic mechanisms maintaining the balance between regulatory and effector functions become impaired, autoimmune diseases can develop. We discuss some of the newest advances on the mechanisms of physiopathologic homeostasis that can be employed to develop strategies to restore a dysregulated immune equilibrium. Some of these designs are based on selectively activating regulators of immunity and inflammation instead of broadly suppressing these processes. Promising approaches include the use of nanoparticles (NPs) to restore Treg control over self-reactive cells, aiming to achieve long-term disease remission, and potentially to prevent autoimmunity in susceptible individuals.
- Published
- 2019
- Full Text
- View/download PDF
280. Eco-Friendly Methods of Gold Nanoparticles Synthesis
- Author
-
Merna M. Abd El-Hameed, Amina S. El-Feky, Alyaa A. Elfky, Taiseer M. Abde El-Daim, Heba M. Fahmy, Yomna H. Elkomy, Donia A. Gomaa, Amany M. Hamad, and Nawal A. Farouk
- Subjects
0106 biological sciences ,Chemistry ,Colloidal gold ,010608 biotechnology ,General Engineering ,General Materials Science ,Nanotechnology ,02 engineering and technology ,021001 nanoscience & nanotechnology ,0210 nano-technology ,01 natural sciences ,Environmentally friendly - Abstract
Background:Owing to the importance of metallic nanoparticles, different researches and studies have been induced to synthesize them in many ways. One of the ways that paid attention last years is the green synthesis methods of nanoparticles or the so-called ''eco-friendly methods''. The most common sources that has been used for green synthesis of nanoparticles are plants, leaves, fungi and microorganisms. The green synthesis methods are widely used because they are inexpensive, usable, and nontoxic. Moreover, plant extracts are rich in reducing and capping agents.Methods:In the present review, green synthesis methods of gold nanoparticles (AuNps) using Chitosan, Klebsiella pneumoniae, Magnolia Kobus, Elettaria cardamomum (Elaichi) aqueous extract and other agents as a reducing/capping agents will be discussed in details. Moreover, we will make a comparison between different green routes of synthesis and the characterization of the obtained nanoparticles from each route.Results:The characterization and applications of the prepared GNPs from different routes are reviewed.Conclusion:The utilization of gold nanoparticles has been advocated because of their high biocomptability, administration in clinical applicability and in diverse aspects of life. It seems that plants are good candidates for nanoparticles production because they are inexpensive, available and renewable sources in addition, it is too simple to prepare extracts from them. Moreover, the great diversity in the types and amounts of reducing agents from plant extracts is responsible for the effortless generation of metallic nanoparticles of various shapes and morphologies.
- Published
- 2019
- Full Text
- View/download PDF
281. Does a diabetic retinopathy educational program raise awareness among elderly diabetic patients?
- Author
-
Ahmed K. Ibrahim, Manal E Ez Eldeen, Azza Elkady, Fatma R. Khalaf, Heba M. Fahmy, Helal F Hetta, and Ghada A. Mohamed
- Subjects
Pharmacology ,Research design ,medicine.medical_specialty ,business.industry ,030209 endocrinology & metabolism ,Diabetic retinopathy ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Bayesian multivariate linear regression ,Internal medicine ,Structured interview ,Internal Medicine ,medicine ,Family history ,business ,Complication ,Educational program - Abstract
Background and aim Diabetic retinopathy is a serious and common complication of diabetes that causes irreversible blindness. The aim of the present study was to assess the knowledge, attitudes, and practice regarding diabetic retinopathy among patients attending a diabetic clinic and identify the effect of an educational program about diabetic retinopathy. Patients and methods Two hundred diabetic patients were recruited from the outpatient's diabetic clinic, Assiut University hospitals, Egypt. Quasi-experimental (pretest-posttest) research design was applied using a structured interview questionnaire; including socio-demographic data, assessment of the patients' knowledge, attitude, and practices toward diabetic retinopathy. Results The mean score of knowledge and attitude showed significant improvement (5.3 and 15.1, respectively in pretest vs 16.7 and 16.8, respectively in posttest) among the diabetic patients (p
- Published
- 2019
- Full Text
- View/download PDF
282. Does vitamin D status correlate with insulin resistance in obese prediabetic patients? An Egyptian multicenter study
- Author
-
Helal F Hetta, Ghada A. Mohamed, Eman M Fahmy, Marwa A. Gaber, Azza Elkady, Israa M.S. Al-Kadmy, and Mohamed M. Elbadr
- Subjects
Adult ,Blood Glucose ,Male ,Vitamin ,medicine.medical_specialty ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Type 2 diabetes ,vitamin D deficiency ,Prediabetic State ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Insulin resistance ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Vitamin D and neurology ,Humans ,Obesity ,030212 general & internal medicine ,Prediabetes ,Vitamin D ,Glycated Hemoglobin ,business.industry ,Incidence ,nutritional and metabolic diseases ,Vitamins ,General Medicine ,Prognosis ,Vitamin D Deficiency ,medicine.disease ,Cross-Sectional Studies ,Endocrinology ,chemistry ,Case-Control Studies ,Egypt ,Female ,Insulin Resistance ,business ,Body mass index ,Biomarkers ,Follow-Up Studies - Abstract
Background The link between Vitamin-D deficiency and type 2 diabetes (T2D) is well-established. Since prediabetic obese populations have the greatest risk to develop to T2D, it was important in our study to examine serum 25(OH) D3 concentration among prediabetic obese patients and to evaluate the correlation between serum level of vitamin D and BMI, FBS, HOMA IR and HbA1c among prediabetes patients. Methods A multicenter case control study was carried out among 101 prediabetic persons & 50 controls, after obtaining consent from subjects and clearance from institutional ethics committee. Serum vitamin D level, Plasma levels of glycosylated hemoglobin (HbA1c) and fasting insulin levels were measured by ELISA in both groups enrolled in the study. Results The prevalence of vitamin-D deficiency/insufficiency was (73.3%) (n = 74) among 101 prediabetic obese individuals. Also, A significant inverse correlation was observed between vitamin D levels & body mass index(r = - 0.28, P = 0.004); fasting blood sugar (r = - 0.22, P = 0.002); HOMA insulin resistance (r = - 0.25 P = 0.01); HbA1C (r = - 0.2, P = 0.004). Conclusions High prevalence of vitamin D deficiency exists among obese prediabetic individuals and there is significant inverse correlation between BMI, FBS, HOMA IR, HbA1c and vitamin D level.
- Published
- 2019
- Full Text
- View/download PDF
283. Molecular and Pathological Variability Associated with Transposable Elements of Botrytis Cinerea Isolates Infecting Grape and Strawberry in Egypt
- Author
-
Mohamed R. A. Shehata, Magda M. Fahmy, Mahmoud A. Gaber, Hala Abdel Wahab, and Elsayed E. Wagih
- Subjects
Transposable element ,Genetics ,Phylogenetic tree ,food and beverages ,Virulence ,Plant Science ,Biology ,biology.organism_classification ,Agricultural and Biological Sciences (miscellaneous) ,Polymorphism (computer science) ,GenBank ,Typing ,Genetic variability ,Agronomy and Crop Science ,Botrytis cinerea - Abstract
Grey mold caused by Botrytis cinerea , is known to cause great losses in most vegetable and fruit crops. Fifty-one isolates of B. cinerea were collected from grape (BCG) and strawberry (BCS) grown in different Egyptian locations. Variation among isolates was demonstrated using fenhexamid resistance and genetic approaches. Isolates were classified into various pathogenic groups depending on their reactions towards lettuce leaves. Genetic variability was identified in all isolates using transposable elements (TEs) analysis which revealed either the presence or absence of boty and flipper transposons. Furthermore, TEs typing of B. cinerea isolates demonstrated four TE types, on the basis of TE distribution in B. cinerea populations, namely, transposa (having both boty and flipper), flipper (possessing only flipper ), boty (having only boty ) , and vacuma (lacking both boty and flipper elements). Transposa type was predominant (43.1%) and both transposa and vacuma isolate types showed no specialization with respect to host plant or plant location, while flipper type revealed a geographical preference in (BCG) isolates. Pathogenicity was also correlated to TE type as isolates containing transposa type revealed some degree of correlation with virulence behaviour, suggesting that transposa populations have higher pathogenic potential as compared to vacuma ones. The sensitivity of sampled isolates was tested against fenhexamid as one of the most important botryticides. Sensitivity to fenhexamid was shown in all isolates from strawberry and grape, grown in different locations, with low EC50 values between 0.012-0.084 μg/ml. This finding provided a cue for effective usage of fenhexamid for grey mold management. The present work demonstrated a correlation between the distribution of TEs and some fungal features such as isolate source and virulence, but no correlation was found between morphological characteristics, TE type, and sensitivity to fenhexamid. Cluster analysis based on phylogenetic tree showed that the Egyptian isolates branched as a separate divergent group from the others retrieved from GenBank, reflecting the presence of sequence polymorphism between the current isolates of B. cinerea and those previously identified.
- Published
- 2019
- Full Text
- View/download PDF
284. Detection of patatin-like phospholipase domain-containing protein 3 in nonalcoholic fatty liver disease among egyptian patients
- Author
-
Eman M. Fahmy, Kadry M. El Saeed, Mohamed O. Khalifa, and Ossama A. Ahmed
- Subjects
lcsh:Internal medicine ,medicine.medical_specialty ,Population ,030209 endocrinology & metabolism ,Overweight ,digestive system ,03 medical and health sciences ,0302 clinical medicine ,NAFLD ,Internal medicine ,Nonalcoholic fatty liver disease ,Biopsy ,medicine ,lcsh:RC31-1245 ,education ,PNPLA3 ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Fatty liver ,NASH ,nutritional and metabolic diseases ,medicine.disease ,digestive system diseases ,simple steatosis ,Liver biopsy ,030211 gastroenterology & hepatology ,medicine.symptom ,Steatohepatitis ,Lipid profile ,business - Abstract
Background and aim Recently, studies have identified patain-like phospholipase domain containing 3 (PNPLA3), which is localized in the endoplasmic reticulum and at the surface of lipid droplets. The association of PNPLA3 polymorphisms with fatty liver and histological severity of NAFLD was shown in many studies. We aimed to investigate the association of PNPLA3 with the development and severity of NAFLD in an overweight and obese Egyptian population. Patients and methods Eighty overweight and obese patients with NAFLD were enrolled in the study. Patients were divided into 2 subgroups according to results of liver biopsy: group 1 included 30 patients with simple steatosis, and group 2 included 50 patients with non-alcoholic steatohepatitis (NASH). In addition to 10 age-matched healthy subjects served as a control group. All NAFLD patients underwent a confirmatory biopsy. Laboratory investigations included fasting glucose, liver enzymes and lipid profile were done. Abdominal ultrasound was performed and PNPLA3 was detected in each patient by Quantitative ELISA. Results Levels of PNPLA3 were higher in NAFLD patients compared with controls (85.70±76.42 vs 3.10±2.11 respectively) and levels were also higher in NASH than simple steatosis (125.09±71.78 vs 20.06±8.47 vs 3.10±2.11 respectively, P
- Published
- 2019
- Full Text
- View/download PDF
285. In vitro acaricidal effect of Melia azedarach and Artemisia herba-alba extracts on Hyalomma dromedarii (Acari: Ixodidae): embryonated eggs and engorged nymphs
- Author
-
Rabab M. El-Khateeb, Essam M. Hoballah, M M Fahmy, Mai M. Abuowarda, Sobhy Abdel-Shafy, and Hoda S. M. Abdel-Ghany
- Subjects
0301 basic medicine ,Veterinary medicine ,Acaricide ,Melia azedarach ,030231 tropical medicine ,Embryonated ,030108 mycology & parasitology ,Biology ,biology.organism_classification ,Hyalomma dromedarii ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Deltamethrin ,chemistry ,Artemisia ,Parasitology ,Petroleum ether ,Nymph - Abstract
The present study aimed to evaluate the in vitro efficacy of four medicinal plant extracts: petroleum ether and ethyl alcohol extracts of the ripen fruits of Melia azedarach and whole aerial parts of Artemisia herba-alba against the two inactive stages of the camel tick Hyalomma dromedarii, embryonated eggs and engorged nymphs in comparison to reference acaricide Butox®5.0 (Deltamethrin). Egg and nymphal immersion tests at four concentrations with three replicates were used. The deformity in larvae hatched from treated eggs and adults moulted from treated nymphs were observed and photographed by light microscope (LM) and scanning electron microscope (SEM). The results showed that M. azedarach and A. herba-alba extracts revealed higher significant toxic effects on embryonated eggs and engorged nymphs comparing with the reference acaricide (Butox®5.0) and control. In egg emmersion test, the LC50 of petroleum ether extracts of M. azedarach and A. herba-alba was 3.14 and 3.91%, respectively and LC50 of the respective ethyl alcohol extracts was 1.77 and 2.45%. In nymphal immersion test, LC50 of petroleum ether extracts of M. azedarach and A. herba-alba was 0.26 and 1%, respectively, and LC50 of the respective ethyl alcohol extracts was 4.17 and 8.7%. Abnormalities were observed by LM and SEM in the larvae hatched from the treated eggs as incomplete development of legs and mouth parts as well as shrinkage mainly in legs and mouthparts of adults emerged from treated nymphs. In conclusion, all extracts and petroleum ether extracts of the two plants have great potential to be developed as a novel acaricidal for controlling eggs and nymphs of H. dromedarii, respectively.
- Published
- 2019
- Full Text
- View/download PDF
286. Partial Kinetic Analysis of Haemolymph Esterases From The Red Palm Weevil; Rhynchophorus ferrugineus Oliv. (Coleoptera: Curculionidae)
- Author
-
Tarek R. Amin and Nedal M. Fahmy
- Subjects
Horticulture ,Rhynchophorus ,biology ,Weevil ,Curculionidae ,Kinetic analysis ,Hemolymph ,Palm ,biology.organism_classification - Published
- 2019
- Full Text
- View/download PDF
287. Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice
- Author
-
Romain Cayrol, Diana Matheoud, Samantha Gruenheid, Marie-Josée Bourque, Annie Laplante, Michel Desjardins, Lei Zhu, Heidi M. McBride, Charles Ducrot, Anna-Maija Penttinen, Lauriane Ramet, Aurore Voisin, Ahmed M. Fahmy, Armelle Le Campion, Tyler Cannon, and Louis-Eric Trudeau
- Subjects
0301 basic medicine ,Multidisciplinary ,Parkinson's disease ,Pars compacta ,business.industry ,Dopaminergic ,PINK1 ,Mitochondrion ,Acquired immune system ,medicine.disease ,Parkin ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Mitophagy ,Immunology ,Medicine ,business ,030217 neurology & neurosurgery - Abstract
Parkinson’s disease is a neurodegenerative disorder with motor symptoms linked to the loss of dopaminergic neurons in the substantia nigra compacta. Although the mechanisms that trigger the loss of dopaminergic neurons are unclear, mitochondrial dysfunction and inflammation are thought to have key roles1,2. An early-onset form of Parkinson’s disease is associated with mutations in the PINK1 kinase and PRKN ubiquitin ligase genes3. PINK1 and Parkin (encoded by PRKN) are involved in the clearance of damaged mitochondria in cultured cells4, but recent evidence obtained using knockout and knockin mouse models have led to contradictory results regarding the contributions of PINK1 and Parkin to mitophagy in vivo5–8. It has previously been shown that PINK1 and Parkin have a key role in adaptive immunity by repressing presentation of mitochondrial antigens9, which suggests that autoimmune mechanisms participate in the aetiology of Parkinson’s disease. Here we show that intestinal infection with Gram-negative bacteria in Pink1−/− mice engages mitochondrial antigen presentation and autoimmune mechanisms that elicit the establishment of cytotoxic mitochondria-specific CD8+ T cells in the periphery and in the brain. Notably, these mice show a sharp decrease in the density of dopaminergic axonal varicosities in the striatum and are affected by motor impairment that is reversed after treatment with l-DOPA. These data support the idea that PINK1 is a repressor of the immune system, and provide a pathophysiological model in which intestinal infection acts as a triggering event in Parkinson’s disease, which highlights the relevance of the gut–brain axis in the disease10. In mice lacking PINK1, bacterial infection in the intestine results in mitochondrial antigen presentation and generation of CD8+ T cells, and infected mice develop motor impairments, suggesting that PINK1 suppresses autoimmunity.
- Published
- 2019
- Full Text
- View/download PDF
288. Assessment of Musculoskeletal Ultrasound Guided Injection of The New Regenerative Medicine Techniques (Neural Prolotherapy and Platelet Rich Plasma) Impact versus Well Established Techniques (Steroid Injection) in Cases of Carpal Tunnel Syndrome Secondary to Rheumatoid Arthritis
- Author
-
Hegazy M Altamimy, Mahmoud S. Abd Allah, Ahmed A. Abdel-Aziz, and Ahmed M. Fahmy
- Subjects
musculoskeletal diseases ,0301 basic medicine ,medicine.medical_specialty ,Bursitis ,business.industry ,Prolotherapy ,medicine.medical_treatment ,medicine.disease ,Median nerve ,Rheumatology ,Surgery ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Internal medicine ,Rheumatoid arthritis ,medicine ,Rheumatoid factor ,Extra-Articular ,business ,Carpal tunnel syndrome ,030217 neurology & neurosurgery - Abstract
Background: Rheumatoid arthritis is a systemic rheumatic disease characterized by symmetrical, often erosive and deforming poly-arthritis with extra-articular manifestations in 10–20% of patients, especially those with high titers of rheumatoid factor. Extra articular pathology includes bursitis, tendonitis and neuritis, which results from entrapment, nerve ischemia due to vasculitis or drugs used to treat this condition.Carpal tunnel syndrome is the most common compression neuropathy associated with rheumatoid arthritis. Aim of the Work: To evaluate the efficacy of Neural Prolotherapy and Platelet Rich Plasma in treatment of carpal tunnel syndrome secondary to rheumatoid arthritis. Patients and Methods: Ninety patients with Rheumatoid Arthritis (RA) that were all fulfilling the 2016 ACR/EULAR classification criteria for RA. All were over the age of sixteen years at time of diagnosis, complaining of burning pain or paresthesia in the median nerve distribution of the hand. They were recruited from Rheumatology and Rehabilitation Department at Al-Hussein and Sayed Galal University Hospitals during the period from December 2018 to July 2019. Results: Neural Prolotherapy and Platelet Rich Plasma (PRP) have improved all measured parameters like visual analogue scale (VAS), nerve conduction studies and neuromuscular ultrasonography parameters in carpal tunnel syndrome secondary to rheumatoid arthritis. Conclusion: Neural Prolotherapy and Platelet Rich Plasma proved to be effective treatments of carpal tunnel syndrome secondary to rheumatoid arthritis.
- Published
- 2019
- Full Text
- View/download PDF
289. Alkaloids of genus Erythrina: An updated review
- Author
-
Abdel Nasser B. Singab, Nouran M. Fahmy, Mohamed El-Shazly, and Eman Al-Sayed
- Subjects
biology ,010405 organic chemistry ,DPPH ,Organic Chemistry ,Estrogen receptor ,Plant Science ,Pharmacology ,biology.organism_classification ,medicine.disease ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Analytical Chemistry ,010404 medicinal & biomolecular chemistry ,Leukemia ,chemistry.chemical_compound ,Nicotinic agonist ,chemistry ,Cell culture ,medicine ,Petroleum ether ,Receptor ,Erythrina - Abstract
Genus Erythrina (Fabaceae) comprises several species, which are widely distributed in tropical and subtropical regions of the world. The plants of this genus exhibited significant role in traditional medicine targeting different diseases. Alkaloids and flavonoids were reported as the chief bioactive constituents of this genus with a wide range of biological activities. About 143 alkaloids were isolated from Erythrina sp. Anticonvulsant, anxiolytic, curare-like activity, insecticidal and cytotoxic activities were reported for Erythrina sp. alkaloids. The present work is an overview of the isolated alkaloids from Erythrina sp. with their reported biological activities.[Figure: see text]Abbreviations: CHCl3: Chloroform; CNS: Central nervous system; DCM: Methylene chloride; DPPH: 2,2-Diphenyl-1-picrylhydrazyl; E.: Erythrina; ERα/β: Estrogen receptors α/β; EtOAc: Ethyl acetate; EtOH: Ethanol; Hep-G2: Human liver carcinoma cell lines; HIV: Human immunodeficiency virus; HL-60: Human promyelocytic leukemia cells; K-562: Human immortalized myelogenous leukemia cell line; LPS: Lipopolysaccharide; MeOH: Methanol; MOLT-4: Acute lymphoblastic leukemia cell line; nAChRs: nicotinic acetylcholine receptors; NO: Nitric oxide; NREM: non-rapid eye movement; Pet. ether: Petroleum ether; RBA: Receptor binder affinity; TRAIL: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand.
- Published
- 2019
- Full Text
- View/download PDF
290. Assessment of Knowledge, Practice and Attitude of Pregnant Women for Effect of Calcium during Pregnancy
- Author
-
Tahany Sh. goda, Nadia M. Fahmy, Soad A.S .Ramadan, and Hemat M.ELbana
- Published
- 2019
- Full Text
- View/download PDF
291. The measurement of endometrial volume and sub-endometrial vascularity to replace the traditional endometrial thickness as predictors of in-vitro fertilization success
- Author
-
Ahmed Kamel, Sarah M Hassan, Radwa M Fahmy, Ahmed M. Maged, Wafaa Ramadan, Rasha Elkomy, Fouad A. Abuhamila, and Omar A Ohida
- Subjects
medicine.medical_specialty ,030219 obstetrics & reproductive medicine ,In vitro fertilisation ,urogenital system ,business.industry ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Urology ,Obstetrics and Gynecology ,030209 endocrinology & metabolism ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Vascularity ,Volume (thermodynamics) ,embryonic structures ,medicine ,medicine.symptom ,business ,therapeutics ,Perfusion ,reproductive and urinary physiology - Abstract
To assess the value of endometrial thickness, volume, and sub-endometrial perfusion in women undergoing IVF. In 82 women candidate for ICSI, endometrial thickness and sub-endometrial perfusion were...
- Published
- 2019
- Full Text
- View/download PDF
292. Evaluation of proximate composition, antioxidant and antimicrobial activities of some seaweeds from the Red Sea coast, Egypt
- Author
-
Nayer M. Fahmy, Mohamed Z. Nassar, Islam M. El-Manawy, and Sarah H. Rashedy
- Subjects
Sea coast ,Antioxidant ,medicine.medical_treatment ,Nutritional composition ,medicine ,Food science ,Aquatic Science ,Biology ,Antimicrobial ,Proximate composition - Published
- 2019
- Full Text
- View/download PDF
293. MEDITERRANEAN SEA FRY; A SOURCE OF ISOPOD INFESTATION PROBLEM IN EGYPT WITH REFERENCE TO THE EFFECT OF SALINITY AND TEMPERATURE ON THE SURVIVAL OF LIVONECA REDMANII (ISOPODA: CYMOTHOIDAE) JUVENILE STAGES
- Author
-
Manal M. Zaki, Mai M. Abuowarda, Nisreen E Mahmoud, Elshaimaa Ismael, M M Fahmy, and Eman M. Ismail
- Subjects
0106 biological sciences ,Veterinary medicine ,Cymothoidae ,biology ,010604 marine biology & hydrobiology ,0402 animal and dairy science ,04 agricultural and veterinary sciences ,medicine.disease_cause ,biology.organism_classification ,040201 dairy & animal science ,01 natural sciences ,Degree (temperature) ,Salinity ,Isopoda ,Mediterranean sea ,Infestation ,medicine ,Juvenile ,Survival rate - Abstract
Parasitic isopods have received considerable attention as they cause series impacts on their hosts either alone or with other environmental stresses such as water pollution. The present study investigated the infestation status with isopods among the fry collected from the natural sources .Also to demonstrate the effects of different salinity and temperature combination on the survival rates of the identified isopods under the laboratory conditions. In March 2017,a total of 16 thousand mugiliid fry were sampled from The Fry Collection center at Al Behera Governorate ,Egypt and examined for the presence of isopods .Samples were found infested with a rate of 10.6% , the result which practically documented that isopods were introduced into lake Qarun through dumping millions of infected fry from this source without biosecurity procedures. The isolated juvenile isopods were morphologically and molecularly identified as Livoneca redmanii species by using 16S rRNA gene and recorded in the GenBank with accession number: MK584629. The effects of variables of salinity/ temperature combination on the survival% of the identified juveniles showed that the best survival rate(100%) was recorded in salinity 15 -20% at temperature 25⁰C while the lethal combination was in salinity 10, 20,50 and 60% at temperature 35⁰C . Statistical analysis using A-two way ANOVA indicated a significant interaction between the effect of different degree of temperature and variance of salinity% on the survival of L. redmanii juveniles. Analysis of one way ANOVA indicated that the most effective temperature of overall mean temperature affected on survival of juvenile stage was 35 C⁰ while the most effective salinity percentage on survival of Juvenile from overall mean of salinity % was 10%. Results of this study provided applicable procedures which can be recommended as a precaution measures and for eliminating the isopod juvenile stages among the mugiliid fry.
- Published
- 2019
- Full Text
- View/download PDF
294. Suppression of Murine Lupus by <scp>CD</scp> 4+ and <scp>CD</scp> 8+ Treg Cells Induced by T Cell–Targeted Nanoparticles Loaded With Interleukin‐2 and Transforming Growth Factor β
- Author
-
Sean Bickerton, David A. Horwitz, Antonio La Cava, Michael Koss, and Tarek M. Fahmy
- Subjects
0301 basic medicine ,Interleukin 2 ,Lupus erythematosus ,Systemic lupus erythematosus ,Chemistry ,T cell ,Immunology ,FOXP3 ,medicine.disease ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Immune system ,Rheumatology ,030220 oncology & carcinogenesis ,medicine ,Cancer research ,Immunology and Allergy ,Ex vivo ,medicine.drug ,Transforming growth factor - Abstract
Objective To develop a nanoparticle (NP) platform that can expand both CD4+ and CD8+ Treg cells in vivo for the suppression of autoimmune responses in systemic lupus erythematosus (SLE). Methods Poly(lactic-co-glycolic acid) (PLGA) NPs encapsulating interleukin-2 (IL-2) and transforming growth factor β (TGFβ) were coated with anti-CD2/CD4 antibodies and administered to mice with lupus-like disease induced by the transfer of DBA/2 T cells into (C57BL/6 × DBA/2)F1 (BDF1) mice. The peripheral frequency of Treg cells was monitored ex vivo by flow cytometry. Disease progression was assessed by measuring serum anti-double-stranded DNA antibody levels by enzyme-linked immunosorbent assay. Kidney disease was defined as the presence of proteinuria or renal histopathologic features. Results Anti-CD2/CD4 antibody-coated, but not noncoated, NPs encapsulating IL-2 and TGFβ induced CD4+ and CD8+ FoxP3+ Treg cells in vitro. The optimal dosing regimen of NPs for expansion of CD4+ and CD8+ Treg cells was determined in in vivo studies in mice without lupus and then tested in BDF1 mice with lupus. The administration of anti-CD2/CD4 antibody-coated NPs encapsulating IL-2 and TGFβ resulted in the expansion of CD4+ and CD8+ Treg cells, a marked suppression of anti-DNA antibody production, and reduced renal disease. Conclusion This study shows for the first time that T cell-targeted PLGA NPs encapsulating IL-2 and TGFβ can expand both CD4+ and CD8+ Treg cells in vivo and suppress murine lupus. This approach, which enables the expansion of Treg cells in vivo and inhibits pathogenic immune responses in SLE, could represent a potential new therapeutic modality in autoimmune conditions characterized by impaired Treg cell function associated with IL-2 deficiency.
- Published
- 2019
- Full Text
- View/download PDF
295. GENETIC DIVERSITY ASSESSMENT OF IN VITRO IRRADIATED TOMATO (LYCOPERSICON ESCULENTUM MILL.) USING SCOT MARKERS
- Author
-
A. Abo Doma, El-Fiki El-Fiki, Gamal El-Metabteb, Mohamed Adly, Eman M. Fahmy, and O. Helmy
- Subjects
Horticulture ,Genetic diversity ,Fuel Technology ,Energy Engineering and Power Technology ,Biology ,biology.organism_classification ,In vitro ,Lycopersicon - Published
- 2019
- Full Text
- View/download PDF
296. DEVELOPMENT OF SOME TOLERANT YEAST (SACCHAROMYCES CEREVISIAE) STRAINS TO HEAT AND SALT STRESSES
- Author
-
F. M. I. Badawy, M. M. Sayed, Sara K. Abd El-Maksoud, and Eman M. Fahmy
- Subjects
chemistry.chemical_classification ,Strain (chemistry) ,biology ,Chemistry ,Significant difference ,Saccharomyces cerevisiae ,Energy Engineering and Power Technology ,Salt (chemistry) ,Oxidative phosphorylation ,biology.organism_classification ,Yeast ,Heat stress ,Stress (mechanics) ,Fuel Technology ,Food science - Abstract
All living organisms are subjected to changing in conservational conditions, to which they must adapt to. Stress is defined as a threat refers to the physiological balance of systems critical to survival organisms. Five yeast strains (Saccharomyces cerevisiae) were subjected to different adverse environmental situations, such as thermal, osmotic and oxidative (salt) stresses. The objective of this work was to detect the most tolerant yeast strains under salt or heat stresses. Five yeast strains were exposed in a first experiment to heat stress at 20°C or 40°C beside to the control at 30°C to detect the more tolerant strain. The same yeast strains were subjected in a second experiment to two different concentrations of salt stress (NaCl); 0.5 or 1.0 M, separately, for two days (at 30°C as normal temperature for growth), other strains were exposed to 0.5 M concentration of NaCl for 24 hours, then 1 M for another 24 hours. For the heat stress results, strain S4 was more tolerant at 40oCwith insignificant difference compared to the control (30oC), while it showed significant difference at 20°C. Strain S5 also was more tolerant at 20oC with insignificant difference compared to the control. For salt treatment, the only insignificant value was for strain S3at 0.5M NaCl compared with the control.
- Published
- 2019
- Full Text
- View/download PDF
297. ASSESSMENT OF GENOTОXIC EFFECTS OF SOME FOOD ADDITIVES ON SOME HUMAN CANCER CELLS
- Author
-
Eman M. Fahmy, Ekram S. Ahmed, Shimaa E. Rashad, A. G. Attallah, A. A. Haggran, and F. M. Abdel-Tawab
- Subjects
0303 health sciences ,food.ingredient ,Chemistry ,Monosodium glutamate ,Food additive ,Energy Engineering and Power Technology ,Cancer ,04 agricultural and veterinary sciences ,Pharmacology ,medicine.disease ,040401 food science ,03 medical and health sciences ,chemistry.chemical_compound ,0404 agricultural biotechnology ,Fuel Technology ,food ,Cancer cell ,medicine ,Cytotoxic T cell ,Viability assay ,Lung cancer ,Cytotoxicity ,030304 developmental biology - Abstract
Some food additives commonly used by humans have been recently proved to be mutagenic. It is of significant importance to evaluate their genotoxic effects, since they are frequently consumed by humans in their daily meals. In this study, we investigated the effects of monosodium glutamate (MSG), sodium benzoate (SB) and saffron on human cell lines; lung cancer (A549), breast cancer (MCF7), colon cancer (Caco-3) and normal lung (Wi38) cell line as control. Cytotoxicity of food additives was screened on multiple cell lines and examined by NR assay (Neutral Red assay). The present study focused on the cytotoxic activity of the food additives and its possible underlying mechanisms. The results showed that food additives; MSG, SB and saffron induced profound cytotoxicity in cancer cells of human colon cancer (Caco-3) (IC50 = 33.92, 15.01, 3.98 μg/ml), human breast cancer (MCF7) (IC50 = 12.79, 0.378, 10.73 μg/ml), human lung cancer cell line (A549) (IC50 = 27.37, 0.45, 2.46 μg/ml), respectively. Moreover, food additives exhibited cytotoxic activity on normal lung cell lines (Wi38) (IC50 = 4.25, 0.733, 18.14 μg/ml). These data indicated that food additives decreased cell viability in malignant and nonmalignant cells as well as confirmed the occurrence of their cytotoxic effects.
- Published
- 2019
- Full Text
- View/download PDF
298. Rational spline-nonstandard finite difference scheme for the solution of time-fractional Swift–Hohenberg equation
- Author
-
M. Fahmy, Samah M. Elkholy, and Waheed K. Zahra
- Subjects
0209 industrial biotechnology ,Applied Mathematics ,Finite difference ,020206 networking & telecommunications ,02 engineering and technology ,Nonstandard finite difference scheme ,Swift–Hohenberg equation ,Computational Mathematics ,Spline (mathematics) ,symbols.namesake ,020901 industrial engineering & automation ,Fourier transform ,0202 electrical engineering, electronic engineering, information engineering ,symbols ,Applied mathematics ,Uniqueness ,Grünwald–Letnikov derivative ,Mathematics - Abstract
In this paper, we introduce a new scheme based on rational spline function and nonstandard finite difference technique to solve the time-fractional Swift–Hohenberg equation in the sense of Riemann–Liouville derivative. Via Fourier method, the method is convergent and unconditionally stable. Also, we investigated the existence and uniqueness of the proposed method. Numerical results are demonstrated to validate the applicability and the theoretical results.
- Published
- 2019
- Full Text
- View/download PDF
299. RT-PCR FOR ANTIOXIDANT GENES FROM EGYPTIAN GRAY MANGROVE Avicennia marina UNDER SALT STRESS TO NABQ PROTECTED AREA
- Author
-
Eman M. Fahmy, A. A.M. Elatawy, Mahmoud Magdy, F. M. Abdel-Tawab, and Fareida M. Elsaied
- Subjects
0106 biological sciences ,biology ,010604 marine biology & hydrobiology ,Energy Engineering and Power Technology ,biology.organism_classification ,010603 evolutionary biology ,01 natural sciences ,Molecular biology ,Ferritin ,Superoxide dismutase ,Fuel Technology ,Real-time polymerase chain reaction ,Catalase ,Avicennia marina ,Gene expression ,biology.protein ,Mangrove ,Gene - Abstract
RT-PCR was conducted for four genes implicated for salt tolerance, oxidative and osmotic stresses in Egyptian gray mangroves within Nabq protected area in South Sinai Governorate. The results showed over-expression of the mRNA of ferritin (amFer1) gene as very high expression, followed by increase in mRNA of superoxide dismutase (amSOD1) and ubiquitin conjugation2 (amUBC2). At the same time gene expression of catalase (amCAT1) decreased.
- Published
- 2019
- Full Text
- View/download PDF
300. The Impact of Street Trees on a Typical Urban Canyon in Eastern Cairo Region
- Author
-
W M Elbardisy, M A Salheen, and M Fahmy
- Subjects
General Medicine ,General Chemistry - Abstract
The trend of upgrading urban areas in Egypt is expanding across the region for better urban mobility patterns. Meanwhile, the concerns towards climate change and creating resilient communities are evolving to avoid the dramatic consequences on urban environments. Street trees offer great benefit in climate moderation, particularly in hot arid regions as in Cairo. In this work, different spatial arrangements and locations for evergreen, deciduous trees and palms at NW street canyon are tested using ENVI-met numerical simulation tool. It is aimed to maximize the cooling effect of tree shade on street facades and attain better pedestrian thermal comfort in peak summer times. This ultimately gives better guidance for urban planners and policymakers towards an improved planting design pattern. Comparing simulation results, it is concluded that evergreen trees located at the building edge can provide up to 6°C cooler walls and up to 3.8°C when placed at the building centre. Whilst other tree species have lower cooling effects. Also, these trees have a great role in attaining better thermal comfort levels for pedestrians at the street level. It is recommended to wisely choose suitable tree species and arrangements to maximize the cooling benefits in the urban environment.
- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.