251. beta-adrenergic receptor blockers and the treatment of vasovagal syncope: more nails in the coffin!
- Author
-
Mathias CJ
- Subjects
- Humans, Propranolol therapeutic use, Randomized Controlled Trials as Topic methods, Research Design, Tilt-Table Test, Treatment Failure, Adrenergic beta-Antagonists therapeutic use, Syncope, Vasovagal drug therapy
- Abstract
beta-Adrenergic receptor blockers are one of a number of therapeutic agents promoted as having beneficial effects in vasovagal syncope. In this issue of Clinical Science, Eldadah and co-workers have investigated the effect of the beta-adrenergic receptor blocker propranolol in preventing syncope in a double-blind cross-over trial in eight subjects with a diagnosis based on tilt table testing and elevated plasma adrenaline levels during syncope. Of these, seven did not respond and the authors therefore suggest that this drug has no role in the management of vasovagal syncope. Their laboratory-based study, however, raises a number of issues regarding terminology, choice of subjects, the value and role of investigations directed towards diagnosis and in understanding pathophysiological mechanisms, and the relevance of such trials to individual subjects with vasovagal syncope.
- Published
- 2006
- Full Text
- View/download PDF