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883 results on '"Morbiducci, Umberto"'

251. Incidencia anual de trombosis del stentconfirmadas y factores clínicos predictores en pacientes con SCA tratados con ticagrelor o prasugrel

Author

Raposeiras-Roubín, Sergio, Abu-Assi, Emad, D’Ascenzo, Fabrizio, Fernández-Barbeira, Saleta, Kinnaird, Tim, Ariza-Solé, Albert, Manzano-Fernández, Sergio, Templin, Christian, Velicki, Lazar, Xanthopoulou, Ioanna, Cerrato, Enrico, Quadri, Giorgio, Rognoni, Andrea, Boccuzzi, Giacome, Montabone, Andrea, Taha, Salma, Durante, Alessandro, Gili, Sebastiano, Magnani, Giulia, Autelli, Michele, Grosso, Alberto, Flores Blanco, Pedro, Garay, Alberto, Varbella, Ferdinando, Tommassini, Francesco, Caneiro Queija, Berenice, Cobas Paz, Rafael, Cespón Fernández, María, Muñoz Pousa, Isabel, Gallo, Diego, Morbiducci, Umberto, Domínguez-Rodríguez, Alberto, Baz-Alonso, José Antonio, Valdés, Mariano, Cequier, Ángel, Gaita, Fiorenzo, Alexopoulos, Dimitrios, and Íñiguez-Romo, Andrés

Abstract

Hay muy poca evidencia sobre las tasas de trombosis del stent(TS) en pacientes que reciben tratamiento antiagregante plaquetario doble (TAPD) con ticagrelor o prasugrel. El objetivo de este estudio es analizar la incidencia y predictores de la TS tras un síndrome coronario agudo en pacientes que reciben TAPD con ticagrelor frente a prasugrel.

Published
2019
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266. Using Lacunarity to Characterize Pore Distribution in Scaffolds

Author

FALVO D'URSO LABATE, GIUSEPPE VITTORIO UGO, Pennella, Francesco, Schiavi, Alessandro, Massai, DIANA NADA CATERINA, Deriu, MARCO AGOSTINO, Montevecchi, Franco Maria, and Morbiducci, Umberto

Subjects
porosity, scaffolds, lacunarity, pore distribution
Published
2011

267. Shape of glucose, insulin, C-peptide curves during a three hour oral glucose tolerance test: any relationship with the degree of glucose tolerance?

Author

Tura, A., Morbiducci, Umberto, Sbrignadello, S., Winhofer, Y., Pacini, G., and Kautzky Willer, A.

Abstract

Shape of glucose, insulin, C-peptide curves during a 3-h oral glucose tolerance test: any relationship with the degree of glucose tolerance? Am J Physiol Regul Integr Comp Physiol 300: R941-R948, 2011. First published January 11, 2011; doi:10.1152/ajpregu.00650.2010.--We aimed to analyze the shape of the glucose, insulin, and C-peptide curves during a 3-h oral glucose tolerance test (OGTT). Another aim was defining an index of shape taking into account the whole OGTT pattern. Five-hundred ninety-two OGTT curves were analyzed, mainly from women with former gestational diabetes, with glycemic concentrations characterized by normal glucose tolerance (n 411), impaired glucose metabolism (n 134), and Type 2 diabetes (n 47). Glucose curves were classified according to their shape (monophasic, biphasic, triphasic, and 4/5-phases), and the metabolic condition of the subjects, divided according to the glucose shape stratification, was analyzed. Indices of shape based on the discrete second-order derivative of the curve patterns were also defined. We found that the majority of the glucose curves were monophasic (n 262). Complex shapes were less frequent but not rare (n 37 for the 4/5-phases shape, i.e., three peaks). There was a tendency toward the amelioration of the metabolic condition for increasing complexity of the shape, as indicated by lower glucose concentrations, improved insulin sensitivity and -cell function. The shape index computed on C-peptide, WHOSHCP (WHole-Ogtt-SHape-index-C-peptide), showed a progressive increase [monophasic: 0.93 0.04 (dimensionless); 4/5-phases: 1.35 0.14], and it showed properties typical of -cell function indices. We also found that the type of glucose shape is often associated to similar insulin and C-peptide shape. In conclusion, OGTT curves can be characterized by high variability, and complex OGTT shape is associated with better glucose tolerance. WHOSHCP (WHole-Ogtt-SHapeindex) may be a powerful index of -cell function much simpler than model-based indices. sha

Published
2011
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269. Multiscale Modelling for investigating single molecule effects on the mechanics of actin filaments

Author

Carbone Laura, Bignardi Cristina, Morbiducci Umberto, Bidone Tamara C, Deriu Marco A, and Montevecchi Franco M

Subjects
Persistence length, History, macromolecular substances, Mechanics, Computer Science Applications, Education, Protein filament, chemistry.chemical_compound, Adenosine diphosphate, Molecular dynamics, Monomer, chemistry, Molecule, Adenosine triphosphate, Actin
Abstract

This work presents a preliminary multiscale computational investigation of the effects of nucleotides and cations on the mechanics of actin filaments (F-actin). At the molecular level, Molecular Dynamics (MD) simulations are employed to characterize the rearrangements of the actin monomers (G-actin) in terms of secondary structures evolution in physiological conditions. At the mesoscale level, a coarse grain (CG) procedure is adopted where each monomer is represented by means of Elastic Network Modeling (ENM) technique. At the macroscale level, actin filaments up to hundreds of nanometers are assumed as isotropic and elastic beams and characterized via Rotation Translation Block (RTB) analysis. F-actin bound to adenosine triphosphate (ATP) shows a persistence length around 5 μm, while actin filaments bound to adenosine diphosphate (ADP) have a persistence length of about 3 μm. With magnesium bound to the high affinity binding site of G-actin, the persistence length of F-actin decreases to about 2 μm only in the ADP-bound form of the filament, while the same ion has no effects, in terms of stiffness variation, on the ATP-bound form of F-actin. The molecular mechanisms behind these changes in flexibility are herein elucidated. Thus, this study allows to analyze how the local binding of cations and nucleotides on G-actin induce molecular rearrangements that transmit to the overall F-actin, characterizing shifts of mechanical properties, that can be related with physiological and pathological cellular phenomena, as cell migration and spreading. Further, this study provides the basis for upcoming investigating of network and cellular remodelling at higher length scales.

Published
2011

273. Multiscale impact of nucleotides and cations on the conformational equilibrium, elasticity and rheology of actin filaments and crosslinked networks

Author

Massachusetts Institute of Technology. Department of Mechanical Engineering, Kamm, Roger Dale, Bidone, Tamara Carla, Kim, Taeyoon, Deriu, Marco A., Morbiducci, Umberto, Massachusetts Institute of Technology. Department of Mechanical Engineering, Kamm, Roger Dale, Bidone, Tamara Carla, Kim, Taeyoon, Deriu, Marco A., and Morbiducci, Umberto

Published
2015

284. Upgrade of a bioreactor for soft tissue engineering

Author

FALVO D'URSO LABATE, GIUSEPPE VITTORIO UGO, Mastrangelo, Francesco, D'Agostino, FABIO SALVATORE, Rodriguez Ruiz, A. F., Gentile, Piergiorgio, Deriu, MARCO AGOSTINO, Morbiducci, Umberto, and Montevecchi, Franco Maria

Published
2010

297. Micromixing and microchannel design: vortex shape and entropy

Author

Mastrangelo, Francesco, Pennella, Francesco, Consolo, Filippo, Rasponi, Marco, Redaelli, ALBERTO CESARE LUIGI, Montevecchi, Franco Maria, and Morbiducci, Umberto

Subjects
Helicity, Mixing, Entropy, Vortex identification
Published
2009

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