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The image of the country and its perception in the world is one of the most important directions in the politics of modern states. Modern Russia is a country with a controversial image, and today serious debates are raging around this issue in the scientific community. In this article, we will consider issues related to the perception of the image of Russia in the post-bipolar period. Russia, which has a rich history and geopolitical ambitions, is perceived ambiguously today, for some it is an aggressor country, a patron of undemocratic regimes, and for others it is a state that can challenge the hegemony of the United States. The modern image of the country is based on the basis that the Soviet Union formed. As Joseph Nye once noted, the image was associated with victory in World War II, space exploration, and achievements in sports. Modern attacks on Russia are connected with these issues, an active campaign is being conducted to reassess the results of the Second World War, monuments to Soviet soldiers are being demolished in Eastern Europe, their graves are being desecrated, Russia is being accused of using doping in sports, and the anthem was banned at the Olympic Games. Key words: Russia, Soft power, image, perception, propaganda, Crimea, Putin, regime.

Zinc‐air batteries (ZABs) have attracted considerable attention for their high energy density, safety, low noise, and eco‐friendliness. However, the capacity of mechanically rechargeable ZABs was limited by the cumbersome procedure for replacing the zinc anode, while electrically rechargeable ZABs suffer from issues including low depth of discharge, zinc dendrite and dead zinc formation, and sluggish oxygen evolution reaction, etc. To address these issues, we report a hybrid redox‐mediated zinc‐air fuel cell (HRM‐ZAFC) utilizing 7,8‐dihydroxyphenazine‐2‐sulfonic acid (DHPS) as the anolyte redox mediator, which shifts the zinc oxidation reaction from the electrode surface to a separate fuel tank. This approach decouples fuel feeding and electricity generation, providing greater operation flexibility and scalability for large‐scale power generation applications. The DHPS‐mediated ZAFC exhibited a superior peak power density of 0.51 W/cm2 and a continuous discharge capacity of 48.82 Ah with ZnO as the discharge product in the tank, highlighting its potential for power generation. [ABSTRACT FROM AUTHOR]

Objective: To analyze the interrelation between radiation dose and radiation-induced nasopharyngeal ulcer (RINU) in locoregional recurrent nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiation therapy (IMRT). Methods: Clinical data were collected from 363 patients with locoregional recurrent NPC who received re-irradiated with definitive IMRT from 2009 to 2017. Twenty-nine patients were diagnosed with RINU. Univariate and multivariate analyses were used to re-evaluate the first and second radiotherapy plans and to identify predictive dosimetric factors. Results: All dosimetric parameters were notably associated with the progression to RINU (p < 0.01) using paired samples Wilcoxon signed rank tests. Multivariate analysis showed that EQD2_ ∑ D80 (dose for 80 percent volume of the unilateral nasopharynx lesion) was an independent prognostic factor for RINU (p = 0.001). The area under the ROC curve for EQD2_ ∑ D80 was 0.846 (p < 0.001), and the cutoff point of 137.035 Gy could potentially be the dose tolerance of the nasopharyngeal mucosa. Conclusions: The sum of equivalent dose in 2 Gy fractions (EQD2) in the overlapping volumes between initial and re-irradiated nasopharyngeal mucosal tissue can be effective in predicting the hazard of developing RINU in NPC patients undergoing radical re‑irradiation with IMRT and we propose a EQD2_ ∑ D80 threshold of 137.035 Gy for the nasopharynx. [ABSTRACT FROM AUTHOR]

Many SARS-CoV-2 neutralizing antibodies (nAbs) lose potency against variants of concern. In this study, we developed 2 strategies to produce mutation-resistant antibodies. First, a yeast library expressing mutant receptor binding domains (RBDs) of the spike protein was utilized to screen for potent nAbs that are least susceptible to viral escape. Among the candidate antibodies, P5-22 displayed ultrahigh potency for virus neutralization as well as an outstanding mutation resistance profile. Additionally, P14-44 and P15-16 were recognized as mutation-resistant antibodies with broad betacoronavirus neutralization properties. P15-16 has only 1 binding hotspot, which is K378 in the RBD of SARS-CoV-2. The crystal structure of the P5-22, P14-44, and RBD ternary complex clarified the unique mechanisms that underlie the excellent mutation resistance profiles of these antibodies. Secondly, polymeric IgG enhanced antibody avidity by eliminating P5-22's only hotspot, residue F486 in the RBD, thereby potently blocking cell entry by mutant viruses. Structural and functional analyses of antibodies screened using both potency assays and the yeast RBD library revealed rare, ultrapotent, mutation-resistant nAbs against SARS-CoV-2., Introduction Neutralizing antibodies (nAbs), which show efficacy for prophylactic as well as therapeutic use, are being developed against the spike (S) protein of SARS-CoV-2 (1-8). These nAbs have shown efficacy [...]