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Trabajo presentado en el 10th International Symposium on Reproductive Physiology of Fish (Expanding the knowledge base of reproductive process: from genes to the environment), celebrado en Olhao (Portugal) del 25 al 30 de mayo de 2014., We characterized three deduced sea bass vitellogenin (Vtg) polypeptides with regard to linear and 3-dimensional (3-D) structural and functional features, verified the presence and relative contribution to the yolk of each form of Vtg, and assessed maturational degradation and potential contribution of each product lipovitellin (Lv) to the free amino acid (FAA) pool driving oocyte hydrat ion and supporting early embryonic nutrition.

To compare two different H pylori stool antigen tests as noninvasive diagnostic methods.The study population consisted of 22 upper gastrointestinal system bleeding patients. Urea breath test (UBT), rapid urease test (RUT) and histopathological examination were applied to all patients. Stool specimens from these patients were examined by rapid STRIP!HpSA and one step simple H pylori antigen cassette test for the detection of H pylori antigens.For these 22 patients, 15 (68.2%) were diagnosed as positive and seven (31.8%) were diagnosed negative for H pylori infection by the gold standard methods. Whereas 10 (45.5%) were positive and 12 (54.5%) were diagnosed negative by the rapid STRIP!HpSA test. The sensitivity, specificity, positive and negative predictive values were 60%, 86%, 90% and 50%, respectively. When compared to the gold standard methods, these differences were not significant. However, six patients (27.3%) were positive, and 16 (72.7%) were negative by the simple H pylori stool antigen cassette test. The sensitivity, specificity, positive and negative predictive values were 33%, 86%, 83% and 38%, respectively. Compared to the gold standard methods, the simple H pylori stool antigen cassette test results were significantly different (P = 0.012).Rapid STRIP!HpSA test could be used as a routine diagnostic tool in the microbiology laboratory for assessing clinical significance and eradication control of H pylori in upper gastrointestinal system bleeding patients.

Stevens-Johnson sendromu (SJS) nadir gorulen fakat hayati tehdit edebilen mukokutanoz tutulumun oldugu T hucre aracili bir asiri duyarlilik reaksiyonudur. Olgularin cogu ilaclarla tetiklenmektedir. Enfeksiyonlar, asilar, kimyasallar, sistemik ve malign hastaliklar da etiyolojide rol alabilir. Hastalik genellikle ates, halsizlik, basagrisi, miyalji, artralji ve ust solunum yolu enfeksiyonu gibi prodromal semptomlarla baslar. Stevens-Johnson sendromu icin ozel bir tedavi yontemi bulunmamaktadir. Hastalik tanisinin hizla konmasi, sebep olan ilacin erken donemde kesilmesi ve destek tedavisi tedavinin temelini olusturmaktadir. Sistemik steroid, intravenoz immunglobulin (IVIG) ve siklosporin gibi ilaclar da tedavi amaciyla kullanilmaktadir. Stevens-Johnson sendromu farkindaligini arttirmak, erken tani ve destek tedavinin onemini vurgulamak amaciyla SJS tanisi alan bir olgu sunulmustur. ABSTRACT Stevens-Johnson syndrome (SJS) is a rare but life-threatening, mucocutaneous, T cell mediated hypersensitivity reaction. Most of the cases are triggered by a drug. Infections, vaccines, chemicals, systemic or malign diseases may have also roles in etiology. Disease generally starts with prodromal symptoms including fever, malaise, headache, myalgia or upper respiratory tract infection. There is no specific treatment modality for SJS. Diagnosing the disease rapidly, discontinuation of the suspected drug immediately, and supportive therapy are the main steps in treatment. Medications like systemic steroids, intravenous immunglobulin (IVIG) and cyclosporin are also used in treatment. Our aim in presenting a case of SJS is to increase awareness of this disease, to emphasize importance of immediate diagnosis and supportive therapy.

WOS: 000411484400007, Objective: The incidence of colorectal cancer in developed countries has been found to increase with age. Early diagnosis and screening decrease the mortality rates in colorectal cancer. This study aimed to use inflammatory markers neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and red blood cell distribution width (RDW)as new biomarkers for early diagnosis and screening in patients with colorectal cancer. Materials and Methods: A total of 59 patients with colorectal cancer and 59 age-and sex-matched healthy participants were included in the study. Localization, tumor node metastasis (TNM) stage, and preoperative hemoglobin levels, neutrophil counts, lymphocyte counts, platelet counts, and RDW values were obtained from medical records. Using the receiver operating characteristic (ROC) curve, the optimal cutoff levels of the biomarkers were determined. Results: NLR, PLR, and RDW were significantly higher in patients with colorectal cancer than in healthy participants (p< 0.001). According to ROC analysis, the cutoff value for NLR was 2.05 [area under the curve (AUC): 0.740, sensitivity: 78%, specificity: 66%]; the cutoff value for PLR was 130 (AUC: 0.702, sensitivity: 65%, specificity: 72%); and the cutoff value for RDW was 14 (AUC: 0.774, sensitivity: 68%, specificity: 73%). Conclusions: NLR, PLR, and RDW were found to be significantly higher in patients with colorectal cancer than in healthy participants. Therefore, it is recommended that these additional biomarkers can be used for early diagnosis and screening of colorectal cancer.

WOS: 000377959900167, Gastric cancer is the third highest malignity for cancer-related mortality worldwide. Reduction of morbidity and mortality requires early recognition and management of gastric cancer. In recent years, biomarkers reflecting the systemic inflammatory state have been used for both diagnostic and prognostic testing. Our objective was to determine whether global inflammatory markers such as platelet-to-lymphocyte ratio (PLR), red cell distribution width (RDW), and neutrophil-to-lymphocyte ratio (NLR) have clinical utility in the early diagnosis of gastric cancer. We included 53 individuals diagnosed as stomach cancer, and 53 healthy age-and sex-matched subjects. Preoperative clinical and pathological data as well as information on hemoglobin levels, neutrophil, lymphocyte and platelet counts were derived from the medical records of patients. A receiver-operating characteristic (ROC) curve was calculated to identify potential criteria for using these biomarkers in the diagnosis of gastric cancer. In patients with gastric cancer, PLR, RDW, and NLR were significantly elevated when compared to healthy control subjects (P < 0.001). The optimal diagnostic cut-off was 2.17 in the ROC curve analysis [area under the curve (AUC): 0.750, sensitivity: 73%, specificity: 61%] for NLR, 128 (AUC: 0.747, sensitivity: 72%, specificity: 64%) for PLR, and 14 (AUC: 0.768, sensitivity: 70%, specificity: 74%) for RDW. The present study suggests that NLR, PLR and RDW, which are easily obtained from a routine complete blood count may be useful as potential, biomarkers for determination of early diagnosis and prognosis of gastric cancer

WOS: 000368273200010, PubMed ID: 26834793, Background: Obstructive sleep apnea (OSA) is a major disease that can cause significant mortality and morbidity. Chronic intermittent hypoxia is a potential causal factor in the progression from fatty liver to nonalcoholic steatohepatitis. Objectives: This study evaluated the association between the degree of liver steatosis and severity of nocturnal hypoxia. Patients and Methods: In this study, between December 2011 and December 2013, patients with ultrasound-diagnosed NAFLD evaluated by standart polysomnography were subsequentally recorded. Patients with alcohol use, viral hepatitis and other chronic liver diseases were excluded. We analyzed polysomnographic parameters, steatosis level and severity of obstructive sleep apnea (OSA) in consideration of body mass index (BMI), biochemical tests and ultrasonographic liver data of 137 subjects. Patients with sleep apnea and AHI scores of

66th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) -- NOV 13-17, 2015 -- San Francisco, CA, WOS: 000368375404460, …, Amer Assoc Study Liver Dis