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978 results on '"Tham, Yih-Chung"'

252. Gender Prediction for a Multiethnic Population via Deep Learning Across Different Retinal Fundus Photograph Fields: Retrospective Cross-sectional Study (Preprint)

Author

Betzler, Bjorn Kaijun, primary, Yang, Henrik Hee Seung, additional, Thakur, Sahil, additional, Yu, Marco, additional, Quek, Ten Cheer, additional, Soh, Zhi Da, additional, Lee, Geunyoung, additional, Tham, Yih-Chung, additional, Wong, Tien Yin, additional, Rim, Tyler Hyungtaek, additional, and Cheng, Ching-Yu, additional

Published
2020
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253. A deep-learning system for the assessment of cardiovascular disease risk via the measurement of retinal-vessel calibre

Author

Cheung, Carol Y., primary, Xu, Dejiang, additional, Cheng, Ching-Yu, additional, Sabanayagam, Charumathi, additional, Tham, Yih-Chung, additional, Yu, Marco, additional, Rim, Tyler Hyungtaek, additional, Chai, Chew Yian, additional, Gopinath, Bamini, additional, Mitchell, Paul, additional, Poulton, Richie, additional, Moffitt, Terrie E., additional, Caspi, Avshalom, additional, Yam, Jason C., additional, Tham, Clement C., additional, Jonas, Jost B., additional, Wang, Ya Xing, additional, Song, Su Jeong, additional, Burrell, Louise M., additional, Farouque, Omar, additional, Li, Ling Jun, additional, Tan, Gavin, additional, Ting, Daniel S. W., additional, Hsu, Wynne, additional, Lee, Mong Li, additional, and Wong, Tien Y., additional

Published
2020
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255. Prevalence and Pattern of Geographic Atrophy in Asia

Author

Rim, Tyler Hyungtaek, primary, Kawasaki, Ryo, additional, Tham, Yih-Chung, additional, Kang, Se Woong, additional, Ruamviboonsuk, Paisan, additional, Bikbov, Mukharram M., additional, Miyake, Masahiro, additional, Hao, Jie, additional, Fletcher, Astrid, additional, Sasaki, Mariko, additional, Nangia, Vinay, additional, Sabanayagam, Charumathi, additional, Yu, Marco, additional, Fujiwara, Kohta, additional, Thapa, Raba, additional, Wong, Ian Y., additional, Kayama, Takamasa, additional, Chen, Shih-Jen, additional, Kuang, Tung-Mei, additional, Yamashita, Hidetoshi, additional, Sundaresan, Periasamy, additional, Chan, Jonathan C., additional, van Rens, G.H.M.B., additional, Sonoda, Koh-Hei, additional, Wang, Ya Xing, additional, Panda-Jonas, Songhomitra, additional, Harada, Sei, additional, Kim, Ramasamy, additional, Ganesan, Suganeswari, additional, Raman, Rajiv, additional, Yamashiro, Kenji, additional, Gilmanshin, Timur R., additional, Jenchitr, Watanee, additional, Park, Kyu Hyung, additional, Gemmy Cheung, Chui Ming, additional, Wong, Tien Yin, additional, Wang, Ningli, additional, Jonas, Jost B., additional, Chakravarthy, Usha, additional, Cheng, Ching-Yu, additional, Yanagi, Yasuo, additional, Saenmee, Achareeya, additional, Cao, Kai, additional, George, Ronnie, additional, Kazakbaeva, Gyulli M., additional, Khalimov, Timur A., additional, Khanna, Rohit C., additional, Kim, Hyun Woong, additional, Kulothungan, Vaitheeswaran, additional, Nangia, Prabhat, additional, Mao, Feifei, additional, Matsuda, Fumihiko, additional, Meng, Qianli, additional, Namba, Hiroyuki, additional, Pokawattana, Nattapol, additional, Oh, Jaeryung, additional, Park, Sang Jun, additional, Ravindran, Ravilla, additional, Sharma, Tarun, additional, Shin, Jae Pil, additional, Surya, Janani, additional, Takahashi, Ayako, additional, Takebayashi, Toru, additional, Tsujikawa, Akitaka, additional, Vashist, Praveen, additional, Wei, Wen Bin, additional, Yang, Xiaohui, additional, Yu, Seung-Young, additional, Zainullin, Rinat M., additional, and Zhao, Pei Quan, additional

Published
2020
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256. A Peer-to-Peer Live-Streaming Intervention for Children During COVID-19 Homeschooling to Promote Physical Activity and Reduce Anxiety and Eye Strain: Cluster Randomized Controlled Trial (Preprint)

Author

Zheng, Yingfeng, primary, Wang, Wei, additional, Zhong, Yuxin, additional, Wu, Fengchun, additional, Zhu, Zhuoting, additional, Tham, Yih-Chung, additional, Lamoureux, Ecosse, additional, Xiao, Liang, additional, Zhu, Erta, additional, Liu, Haoning, additional, Jin, Ling, additional, Liang, Linyi, additional, Luo, Lixia, additional, He, Mingguang, additional, Morgan, Ian, additional, Congdon, Nathan, additional, and Liu, Yizhi, additional

Published
2020
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258. Detection of features associated with neovascular age-related macular degeneration in ethnically distinct data sets by an optical coherence tomography: trained deep learning algorithm

Author

Rim, Tyler Hyungtaek, primary, Lee, Aaron Y, additional, Ting, Daniel S, additional, Teo, Kelvin, additional, Betzler, Bjorn Kaijun, additional, Teo, Zhen Ling, additional, Yoo, Tea Keun, additional, Lee, Geunyoung, additional, Kim, Youngnam, additional, Lin, Andrew C, additional, Kim, Seong Eun, additional, Tham, Yih Chung, additional, Kim, Sung Soo, additional, Cheng, Ching-Yu, additional, Wong, Tien Yin, additional, and Cheung, Chui Ming Gemmy, additional

Published
2020
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259. Prevalence and predictors of myopic macular degeneration among Asian adults: pooled analysis from the Asian Eye Epidemiology Consortium

Author

Wong, Yee Ling, primary, Zhu, Xiangjia, additional, Tham, Yih Chung, additional, Yam, Jason C S, additional, Zhang, Keke, additional, Sabanayagam, Charumathi, additional, Lanca, Carla, additional, Zhang, Xiujuan, additional, Han, So Young, additional, He, Wenwen, additional, Susvar, Pradeep, additional, Trivedi, Mihir, additional, Yuan, Nan, additional, Lambat, Sarang, additional, Raman, Rajiv, additional, Song, Su Jeong, additional, Wang, Ya Xing, additional, Bikbov, Mukharram M, additional, Nangia, Vinay, additional, Chen, Li Jia, additional, Wong, Tien Yin, additional, Lamoureux, Ecosse Luc, additional, Pang, Chi-Pui, additional, Cheng, Ching Yu, additional, Lu, Yi, additional, Jonas, Jost B, additional, and Saw, Seang Mei, additional

Published
2020
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260. Association of Glaucoma Risk Genes with Retinal Nerve Fiber Layer in a Multi-ethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study

Author

Chai, Xiaoran, primary, Low, Kok Yao, additional, Tham, Yih Chung, additional, Chee, Miao Li, additional, Thakur, Sahil, additional, Zhang, Liang, additional, Tan, Nicholas Y., additional, Khor, Chiea Chuen, additional, Aung, Tin, additional, Wong, Tien Yin, additional, and Cheng, Ching-Yu, additional

Published
2020
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264. Association of Cataract Surgery With Risk of Diabetic Retinopathy Among Asian Participants in the Singapore Epidemiology of Eye Diseases Study

Author

Tham, Yih-Chung, primary, Liu, Lei, additional, Rim, Tyler Hyungtaek, additional, Zhang, Liang, additional, Majithia, Shivani, additional, Chee, Miao Li, additional, Tan, Nicholas Y. Q., additional, Wong, Kah-Hie, additional, Ting, Daniel Shu Wei, additional, Sabanayagam, Charumathi, additional, Wang, Jie Jin, additional, Mitchell, Paul, additional, Wong, Tien Yin, additional, and Cheng, Ching-Yu, additional

Published
2020
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268. Role of socio-economic factors in visual impairment and progression of diabetic retinopathy

Author

Low, Jin Rong, primary, Gan, Alfred Tau Liang, additional, Fenwick, Eva K, additional, Gupta, Preeti, additional, Wong, Tien Y, additional, Teo, Zhen Ling, additional, Thakur, Sahil, additional, Tham, Yih Chung, additional, Sabanayagam, Charumathi, additional, Cheng, Ching-Yu, additional, Lamoureux, Ecosse Luc, additional, and Man, Ryan Eyn Kidd, additional

Published
2020
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269. Factors affecting the diagnostic performance of circumpapillary retinal nerve fibre layer measurement in glaucoma

Author

Wong, Damon, primary, Chua, Jacqueline, additional, Baskaran, Mani, additional, Tan, Bingyao, additional, Yao, Xinwen, additional, Chan, Samuel, additional, Tham, Yih Chung, additional, Chong, Rachel, additional, Aung, Tin, additional, Lamoureux, Ecosse Luc, additional, Vithana, Eranga N, additional, Cheng, Ching Yu, additional, and Schmetterer, Leopold, additional

Published
2020
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272. Association Between Visual Impairment and Decline in Cognitive Function in a Multiethnic Asian Population

Author

Lim, Zhi Wei, primary, Chee, Miao-Li, additional, Soh, Zhi Da, additional, Cheung, Ning, additional, Dai, Wei, additional, Sahil, Thakur, additional, Tao, Yijin, additional, Majithia, Shivani, additional, Sabanayagam, Charumathi, additional, Chen, Christopher Li-Hsian, additional, Wong, Tien Yin, additional, Cheng, Ching-Yu, additional, and Tham, Yih-Chung, additional

Published
2020
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273. Rates and Determinants of Eyecare Utilization and Eyeglass Affordability Among Individuals With Visual Impairment in a Multi-Ethnic Population-Based Study in Singapore

Author

Gupta, Preeti, primary, Majithia, Shivani, additional, Fenwick, Eva K., additional, Gan, Alfred T. L., additional, Tham, Yih-Chung, additional, Poh, Stanley, additional, Thakur, Sahil, additional, Sabanayagam, Charumathi, additional, Wong, Tien Yin, additional, Cheng, Ching-Yu, additional, and Lamoureux, Ecosse L., additional

Published
2020
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274. Association between Macular Thickness Profiles and Visual Function in Healthy Eyes: The Singapore Epidemiology of Eye Diseases (SEED) Study

Author

Poh, Stanley, primary, Tham, Yih-Chung, additional, Chee, Miao Li, additional, Dai, Wei, additional, Majithia, Shivani, additional, Soh, Zhi Da, additional, Fenwick, Eva K., additional, Tao, Yijin, additional, Thakur, Sahil, additional, Rim, Tyler Hyungtaek, additional, Sabanayagam, Charumathi, additional, and Cheng, Ching-Yu, additional

Published
2020
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277. Near work, screen time, outdoor time and myopia in schoolchildren in the Sunflower Myopia AEEC Consortium.

Author

Lanca, Carla, Yam, Jason C., Jiang, Wen‐Jun, Tham, Yih‐Chung, Hassan Emamian, Mohammad, Tan, Chuen‐Seng, Guo, Yin, Liu, Hu, Zhong, Hua, Zhu, Dan, Hu, Yuan‐Yuan, Saxena, Rohit, Hashemi, Hassan, Chen, Li‐Jia, Wong, Tien‐Yin, Cheng, Ching‐Yu, Pang, Chi‐Pui, Zhu, Hui, Pan, Chen‐Wei, and Liang, Yuan Bo

Subjects
MYOPIA, MEDICAL screening, SCHOOL children, SUNFLOWERS, CITIES & towns
Abstract

Purpose: To examine the association between near work, screen time including TV and outdoor time with myopia in children from the Sunflower Myopia Asian Eye Epidemiology Consortium (AEEC). Methods: We analysed AEEC cross‐sectional data (12 241 children) on risk factors (near work, screen time including TV and outdoor time) and myopia of six population‐based studies (China, Hong Kong and Singapore). Cycloplegic refraction and axial length (AL) measurements were included. Risk factors were determined using questionnaires. Data were pooled from each study, and multivariable regression analysis was performed to evaluate the associations between risks factors and myopia, spherical equivalent (SE) and AL. Results: Among the included children, 52.1% were boys, 98.1% were Chinese and 69.7% lived in urban areas. Mean±standard deviation (SD) for age was 8.8 ± 2.9 years, for SE was −0.14 ± 1.8 D and for AL was 23.3 ± 1.1 mm. Myopia prevalence was 30.6%. In multivariate analysis, more reading and writing (OR = 1.17; 95% CI, 1.11–1.24), more total near work (OR = 1.05; 95% CI, 1.02–1.09) and less outdoor time (OR = 0.82, 95% CI, 0.75–0.88) were associated with myopia (p's < 0.05). These factors were similarly associated with SE and AL (p's < 0.05), except for total near work and AL (p = 0.15). Screen time including TV was not significantly associated with myopia (p = 0.49), SE (p = 0.49) or AL (p = 0.83). Conclusion: In this study, increased reading and writing and decreased outdoor time were associated with myopia. Screen time may be a surrogate factor of near work or outdoor time, but further research is needed to assess its role as an independent risk factor for myopia. [ABSTRACT FROM AUTHOR]

Published
2022
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278. longitudinal association between cognitive impairment and incident visual impairment in a multiethnic Asian population: a prospective cohort study.

Author

Vu, Tai Anh, Gupta, Preeti, Leow, Felicia Z Y, Fenwick, Eva K, Man, Ryan E K, Tham, Yih-Chung, Xu, Xin, Quek, Debra Q Y, Qian, Chaoxu, Sabanayagam, Charumathi, Chen, Christopher L H, Wong, Tien Yin, Cheng, Ching-Yu, and Lamoureux, Ecosse L

Subjects
COGNITION disorders, NOSOLOGY, CONFIDENCE intervals, PSYCHOLOGICAL vulnerability, REGRESSION analysis, DISEASE incidence, COGNITIVE aging, PSYCHOLOGICAL tests, VISION testing, SEVERITY of illness index, VISUAL acuity, DESCRIPTIVE statistics, COGNITION disorders in old age, VISION disorders, LOGISTIC regression analysis, STATISTICAL models, ODDS ratio, LONGITUDINAL method, REFRACTIVE errors, DISEASE risk factors
Abstract

Background The relationship between baseline cognitive impairment (CI) and incident visual impairment (VI) in Asians is unclear. Objective To determine the associations between baseline CI with incident VI and visual acuity (VA) at 6-year follow-up in multiethnic Asians. Design Cohort. Setting Population-based. Subjects Two thousand three hundred and twenty-four adults aged ≥60 years from the Singapore Epidemiology of Eye Diseases Study (response rate 64%). Methods CI was defined using the validated Abbreviated Mental Test (AMT). VA was objectively measured using a LogMAR chart. Any incident VI was defined as having no VI (Snellen's VA better than or equal to 20/40) at baseline but present (VA worse than 20/40) at 6-year follow-up. VI severity was defined according to the International Classification of Diseases, 11th Revision. Associations were assessed using logistic and linear regression models. Results Of the 2,324 participants, 248 had CI at baseline. Presence of baseline CI was associated with more than twice the odds of any incident VI, incident mild and moderate–severe VI (OR [95% confidence interval]: 2.48 [1.55–3.90], 2.07 [1.17–3.55], and 2.61 [1.36–4.93], respectively) and worse VA (β [95% confidence interval]: 0.026 [0.006–0.046]) at 6-year follow-up. The leading causes of incident VI were cataract and under-corrected refractive error. Conclusions Older adults with CI had more than double the odds of VI development and poorer VA than their cognitively intact counterparts, and most causes of incident VI were correctable. Strategies such as targeted vision screening and early intervention for early detection and management of vision loss in patients with cognitive decline are warranted. [ABSTRACT FROM AUTHOR]

Published
2022
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279. Three-dimensional modelling of the choroidal angioarchitecture in a multi-ethnic Asian population.

Author

Cheong, Kai Xiong, Teo, Kelvin Yi Chong, Tham, Yih Chung, Sim, Ralene, Majithia, Shivani, Lee, Jia Min, Tan, Anna Cheng Sim, Cheng, Ching-Yu, Cheung, Chui Ming Gemmy, and Agrawal, Rupesh

Subjects
OPTICAL coherence tomography, ASIANS, THREE-dimensional modeling, CHOROID
Abstract

This study aimed to describe the topographic variation of the macula's choroidal angioarchitecture using three-dimensional (3D) choroidal vascularity index (CVI) of healthy eyes from an Asian population and to investigate the associations of CVI. 50 participants were recruited via stratified randomisation based on subfoveal choroidal thickness from the Singapore Epidemiology of Eye Diseases Study. Macular volume scans were acquired using spectral-domain optical coherence tomography with enhanced depth imaging. CVI was assessed based on B-scan binarisation and choroid segmentation. The 3D CVI of the whole, superior, central, and inferior macula were 62.92 ± 1.57%, 62.75 ± 1.93%, 63.35 ± 1.72%, and 62.66 ± 1.70%, respectively, pairwise comparisons P all > 0.05). 3D CVI (Whole Macula) and 2D CVI (Subfoveal) were associated only with each other and not with other ocular and systemic factors. 2D CVI (Subfoveal) had a moderate agreement with 3D CVI (Central Macula) [intraclass corelation coefficient (ICC) = 0.719], and had poorer agreement with 3D CVI of the whole macula, superior, and inferior macula (ICC = 0.591, 0.483, and 0.394, respectively). Scanning volume did not influence 3D CVI measurements. In conclusion, 3D CVI demonstrated no significant topographic variation. CVI was not correlated with demographic or ocular structural features. 2D CVI of the fovea is partially representative of 3D CVI of the macula. [ABSTRACT FROM AUTHOR]

Published
2022
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280. A deep learning model for detection of Alzheimer's disease based on retinal photographs: a retrospective, multicentre case-control study

Author

Cheung, Carol Y, Ran, An Ran, Wang, Shujun, Chan, Victor T T, Sham, Kaiser, Hilal, Saima, Venketasubramanian, Narayanaswamy, Cheng, Ching-Yu, Sabanayagam, Charumathi, Tham, Yih Chung, Schmetterer, Leopold, McKay, Gareth J, Williams, Michael A, Wong, Adrian, Au, Lisa W C, Lu, Zhihui, Yam, Jason C, Tham, Clement C, Chen, John J, Dumitrascu, Oana M, Heng, Pheng-Ann, Kwok, Timothy C Y, Mok, Vincent C T, Milea, Dan, Chen, Christopher Li-Hsian, and Wong, Tien Yin

Abstract

There is no simple model to screen for Alzheimer's disease, partly because the diagnosis of Alzheimer's disease itself is complex—typically involving expensive and sometimes invasive tests not commonly available outside highly specialised clinical settings. We aimed to develop a deep learning algorithm that could use retinal photographs alone, which is the most common method of non-invasive imaging the retina to detect Alzheimer's disease-dementia.

Published
2022
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281. A catalog of genetic loci associated with kidney function from analyses of a million individuals

Author

Wuttke, Matthias, Li, Yong, Li, Man, Sieber, Karsten B., Feitosa, Mary F., Gorski, Mathias, Tin, Adrienne, Wang, Lihua, Chu, Audrey Y., Hoppmann, Anselm, Kirsten, Holger, Giri, Ayush, Chai, Jin-Fang, Sveinbjornsson, Gardar, Tayo, Bamidele O., Nutile, Teresa, Fuchsberger, Christian, Marten, Jonathan, Cocca, Massimiliano, Ghasemi, Sahar, Xu, Yizhe, Horn, Katrin, Noce, Damia, van der Most, Peter J., Sedaghat, Sanaz, Yu, Zhi, Akiyama, Masato, Afaq, Saima, Ahluwalia, Tarunveer S., Almgren, Peter, Amin, Najaf, Ärnlöv, Johan, Bakker, Stephan J. L., Bansal, Nisha, Baptista, Daniela, Bergmann, Sven, Biggs, Mary L., Biino, Ginevra, Boehnke, Michael, Boerwinkle, Eric, Boissel, Mathilde, Bottinger, Erwin P., Boutin, Thibaud S., Brenner, Hermann, Brumat, Marco, Burkhardt, Ralph, Butterworth, Adam S., Campana, Eric, Campbell, Archie, Campbell, Harry, Canouil, Mickaël, Carroll, Robert J., Catamo, Eulalia, Chambers, John C., Chee, Miao-Ling, Chee, Miao-Li, Chen, Xu, Cheng, Ching-Yu, Cheng, Yurong, Christensen, Kaare, Cifkova, Renata, Ciullo, Marina, Pina Concas, Maria, Cook, James P., Coresh, Josef, Corre, Tanguy, Sala, Cinzia Felicita, Cusi, Daniele, Danesh, John, Daw, E. Warwick, de Borst, Martin H., De Grandi, Alessandro, de Mutsert, Renée, de Vries, Aiko P. J., Degenhardt, Frauke, Delgado, Graciela, Demirkan, Ayse, Di Angelantonio, Emanuele, Dittrich, Katalin, Divers, Jasmin, Dorajoo, Rajkumar, Eckardt, Kai-Uwe, Ehret, Georg, Elliott, Paul, Endlich, Karlhans, Evans, Michele K., Felix, Janine F., Foo, Valencia Hui Xian, Franco, Oscar H., Franke, Andre, Freedman, Barry I., Freitag-Wolf, Sandra, Friedlander, Yechiel, Froguel, Philippe, Gansevoort, Ron T., Gao, He, Gasparini, Paolo, Gaziano, J. Michael, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Giulianini, Franco, Gögele, Martin, Gordon, Scott D., Gudbjartsson, Daniel F., Gudnason, Vilmundur, Haller, Toomas, Hamet, Pavel, Harris, Tamara B., Hartman, Catharina A., Hayward, Caroline, Hellwege, Jacklyn N., Heng, Chew-Kiat, Hickst, Andrew A., Hofer, Edith, Huang, Wei, Hutri-Kähönen, Nina, Hwang, Shih-Jen, ikram, M. Arfan, indridason, Olafur S., Ingelsson, Erik, ising, Marcus, Jaddoe, Vincent W. V., Jakobsdottir, Johanna, Jonas, Jost B, Joshi, Peter K., Shilpa Josyula, Navya, Jung, Bettina, Kähönen, Mika, Kamatani, Yoichiro, Kammerer, Candace M., Kanai, Masahiro, Kastarinen, Mika, Kerr, Shona M., Khor, Chiea-Chuen, Kiess, Wieland, Kleber, Marcus E., Koenig, Wolfgang, Kooner, Jaspal S., Körner, Antje, Kovacs, Peter, Kraja, Aldi T., Krajcoviechova, Alena, Kramer, Holly, Krämer, Bernhard K., Kronenberg, Florian, Kubo, Michiaki, Kühnel, Brigitte, Kuokkanen, Mikko, Kuusisto, Johanna, La Bianca, Martina, Laakso, Markku, Lange, Leslie A., Langefeld, Carl D., Jen-Mai Lee, Jeannette, Lehne, Benjamin, Lehtimäki, Terho, Lieb, Wolfgang, Cohort Study, Lifelines, Lim, Su-Chi, Lind, Lars, Lindgren, Cecilia M., Liu, Jun, Liu, Jianjun, Loeffler, Markus, Loos, Ruth J. F., Lucae, Susanne, Ann Lukas, Mary, Lyytikäinen, Leo-Pekka, Mägi, Reedik, Magnusson, Patrik K. E., Mahajan, Anubha, Martin, Nicholas G., Martins, Jade, März, Winfried, Mascalzoni, Deborah, Matsuda, Koichi, Christa Meisinger, Meitinger, Thomas, Melander, Olle, Metspalu, Andres, Mikaelsdottir, Evgenia K., Milaneschi, Yuri, Miliku, Kozeta, Mishra, Pashupati P., Veteran Program, V. A. Million, Mohlke, Karen L., Mononen, Nina, Montgomery, Grant W., Mook-Kanamori, Dennis O., Mychaleckyj, Josyf C., Nadkarni, Girish N, Nalls, Mike A., Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, ilja M., Noordam, Raymond, O’Connell, Jeffrey, O’Donoghue, Michelle L., Olafsson, Isleifur, Oldehinkel, Albertine J., Orho-Melander, Marju, Ouwehand, Willem H., Padmanabhan, Sandosh, Palmer, Nicholette D., Palsson, Runolfur, Penninx, Brenda W. J. H., Perls, Thomas, Perola, Markus, Pirastu, Mario, Pirastu, Nicola, Pistis, Giorgio, Podgornaia, Anna I., Polasek, Ozren, Ponte, Belen, Porteous, David J., Poulain, Tanja, Pramstaller, Peter P., Preuss, Michael H., Prins, Bram P., Province, Michael A., Rabelink, Ton J., Raffield, Laura M., Raitakari, Olli T., Reilly, Dermot F., Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M., Ridker, Paul M., Rivadeneira, Fernando, Rizzi, Federica, Roberts, David J., Robino, Antonietta, Rossing, Peter, Rudan, Igor, Rueedi, Rico, Ruggiero, Daniela, Ryan, Kathleen A., Saba, Yasaman, Sabanayagam, Charumathi, Salomaa, Veikko, Salvi, Erika, Saum, Kai-Uwe, Schmidt, Helena, Schmidt, Reinhold, Schöttker, Ben, Schulz, Christina-Alexandra, Schupf, Nicole, Shaffer, Christian M., Shi, Yuan, Smith, Albert V., Smith, Blair H., Soranzo, Nicole, Spracklen, Cassandra N., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Svensson, Per O., Szymczak, Silke, Tai, E-Shyong, Tajuddin, Salman M., Tan, Nicholas Y. Q., Taylor, Kent D., Teren, Andrej, Tham, Yih-Chung, Thiery, Joachim, Thio, Chris H. L., Thomsen, Hauke, Thorleifsson, Gudmar, Toniolo, Daniela, Tönjes, Anke, Tremblay, Johanne, Tzoulaki, Ioanna, Uitterlinden, André G., Vaccargiu, Simona, van Dam, Rob M., van der Harst, Pim, van Duijn, Cornelia M., Velez Edward, Digna R., Verweij, Niek, Vogelezang, suzanne, Völker, üwe, Vollenweider, Peter, Waeber, Gerard, Waldenberger, Melanie, Wallentin, Lars, Wang, Ya Xing, Wang, Chaolong, Waterworth, Dawn M., Bin Wei, Wen, White, Harvey, Whitfield, John B., Wild, Sarah H., Wilson, James F., Wojczynski, Mary K., Wong, Charlene, Wong, Tien-Yin, Xu, Liang, Yang, Qiong, Yasuda, Masayuki, Yerges-Armstrong, Laura M., Zhang, Weihua, Zonderman, Alan B., Rotter, Jerome I., Bochud, Murielle, Psaty, Bruce M., Vitart, Veronique, Wilson, James G., Dehghan, Abbas, Parsa, Afshin, Chasman, Daniel I., Ho, Kevin, Morris, Andrew P., Devuyst, Olivier, Akilesh, Shreeram, Pendergrass, Sarah A., Sim, Xueling, Böger, Carsten A., Okada, Yukinori, Edwards, Todd L., Snieder, Harold, Stefansson, Kari, Hung, Adriana M., Heid, Iris M., Markus Scholz, Teumer, Alexander, Köttgen, Anna, Pattaro, Cristian, Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Internal Medicine, Epidemiology, Erasmus MC other, Pediatrics, Psychiatry, APH - Mental Health, APH - Digital Health, Wuttke, M, Li, Y, Li, M, Sieber, Kb, Feitosa, Mf, Gorski, M, Tin, A, Wang, L, Chu, Ay, Hoppmann, A, Kirsten, H, Giri, A, Chai, Jf, Sveinbjornsson, G, Tayo, Bo, Nutile, T, Fuchsberger, C, Marten, J, Cocca, M, Ghasemi, S, Xu, Y, Horn, K, Noce, D, van der Most, Pj, Sedaghat, S, Yu, Z, Akiyama, M, Afaq, S, Ahluwalia, T, Almgren, P, Amin, N, Ärnlöv, J, Bakker, Sjl, Bansal, N, Baptista, D, Bergmann, S, Biggs, Ml, Biino, G, Boehnke, M, Boerwinkle, E, Boissel, M, Bottinger, Ep, Boutin, T, Brenner, H, Brumat, M, Burkhardt, R, Butterworth, A, Campana, Eric, Campbell, A, Campbell, H, Canouil, M, Carroll, Rj, Catamo, E, Chambers, Jc, Chee, Ml, Chen, X, Cheng, Cy, Cheng, Y, Christensen, K, Cifkova, R, Ciullo, M, Concas, Mp, Cook, Jp, Coresh, J, Corre, T, Sala, Cf, Cusi, D, Danesh, J, Daw, Ew, de Borst, Mh, De Grandi, A, de Mutsert, R, de Vries, Apj, Degenhardt, F, Delgado, G, Demirkan, A, Di Angelantonio, E, Dittrich, K, Divers, J, Dorajoo, R, Eckardt, Ku, Ehret, G, Elliott, P, Endlich, K, Evans, Mk, Felix, Jf, Foo, Vhx, Franco, Oh, Franke, A, Freedman, Bi, Freitag-Wolf, S, Friedlander, Y, Froguel, P, Gansevoort, Rt, Gao, H, Gasparini, P, Gaziano, Jm, Giedraitis, V, Gieger, C, Girotto, G, Giulianini, F, Gögele, M, Gordon, Sd, Gudbjartsson, Df, Gudnason, V, Haller, T, Hamet, P, Harris, Tb, Hartman, Ca, Hayward, C, Hellwege, Jn, Heng, Ck, Hicks, Aa, Hofer, E, Huang, W, Hutri-Kähönen, N, Hwang, Sj, Ikram, Ma, Indridason, O, Ingelsson, E, Ising, M, Jaddoe, Vwv, Jakobsdottir, J, Jonas, Jb, Joshi, Pk, Josyula, N, Jung, B, Kähönen, M, Kamatani, Y, Kammerer, Cm, Kanai, M, Kastarinen, M, Kerr, Sm, Khor, Cc, Kiess, W, Kleber, Me, Koenig, W, Kooner, J, Körner, A, Kovacs, P, Kraja, At, Krajcoviechova, A, Kramer, H, Krämer, Bk, Kronenberg, F, Kubo, M, Kühnel, B, Kuokkanen, M, Kuusisto, J, La Bianca, M, Laakso, M, Lange, La, Langefeld, Cd, Lee, Jj, Lehne, B, Lehtimäki, T, Lieb, W, Lifelines Cohort, Study, Lim, Sc, Lind, L, Lindgren, Cm, Liu, J, Loeffler, M, Loos, Rjf, Lucae, S, Lukas, Ma, Lyytikäinen, Lp, Mägi, R, Magnusson, Pke, Mahajan, A, Martin, Ng, Martins, J, März, W, Mascalzoni, D, Matsuda, K, Meisinger, C, Meitinger, T, Melander, O, Metspalu, A, Mikaelsdottir, Ek, Milaneschi, Y, Miliku, K, Mishra, Pp, V. A., Million Veteran Program, Mohlke, Kl, Mononen, N, Montgomery, Gw, Mook-Kanamori, Do, Mychaleckyj, Jc, Nadkarni, Gn, Nalls, Ma, Nauck, M, Nikus, K, Ning, B, Nolte, Im, Noordam, R, O'Connell, J, O'Donoghue, Ml, Olafsson, I, Oldehinkel, Aj, Orho-Melander, M, Ouwehand, Wh, Padmanabhan, S, Palmer, Nd, Palsson, R, Penninx, Bwjh, Perls, T, Perola, M, Pirastu, M, Pirastu, N, Pistis, G, Podgornaia, Ai, Polasek, O, Ponte, B, Porteous, Dj, Poulain, T, Pramstaller, Pp, Preuss, Mh, Prins, Bp, Province, Ma, Rabelink, Tj, Raffield, Lm, Raitakari, Ot, Reilly, Df, Rettig, R, Rheinberger, M, Rice, Km, Ridker, Pm, Rivadeneira, F, Rizzi, F, Roberts, Dj, Robino, A, Rossing, P, Rudan, I, Rueedi, R, Ruggiero, D, Ryan, Ka, Saba, Y, Sabanayagam, C, Salomaa, V, Salvi, E, Saum, Ku, Schmidt, H, Schmidt, R, Schöttker, B, Schulz, Ca, Schupf, N, Shaffer, Cm, Shi, Y, Smith, Av, Smith, Bh, Soranzo, N, Spracklen, Cn, Strauch, K, Stringham, Hm, Stumvoll, M, Svensson, Po, Szymczak, S, Tai, E, Tajuddin, Sm, Tan, Nyq, Taylor, Kd, Teren, A, Tham, Yc, Thiery, J, Thio, Chl, Thomsen, H, Thorleifsson, G, Toniolo, D, Tönjes, A, Tremblay, J, Tzoulaki, I, Uitterlinden, Ag, Vaccargiu, S, van Dam, Rm, van der Harst, P, van Duijn, Cm, Velez Edward, Dr, Verweij, N, Vogelezang, S, Völker, U, Vollenweider, P, Waeber, G, Waldenberger, M, Wallentin, L, Wang, Yx, Wang, C, Waterworth, Dm, Bin Wei, W, White, H, Whitfield, Jb, Wild, Sh, Wilson, Jf, Wojczynski, Mk, Wong, C, Wong, Ty, Xu, L, Yang, Q, Yasuda, M, Yerges-Armstrong, Lm, Zhang, W, Zonderman, Ab, Rotter, Ji, Bochud, M, Psaty, Bm, Vitart, V, Wilson, Jg, Dehghan, A, Parsa, A, Chasman, Di, Ho, K, Morris, Ap, Devuyst, O, Akilesh, S, Pendergrass, Sa, Sim, X, Böger, Ca, Okada, Y, Edwards, Tl, Snieder, H, Stefansson, K, Hung, Am, Heid, Im, Scholz, M, Teumer, A, Köttgen, A, and Pattaro, C.

Subjects
catalog, Inheritance Patterns, Hasso-Plattner-Institut für Digital Engineering GmbH, Genome-wide association study, Disease, Kidney Function Tests, Bioinformatics, DISEASE, 0302 clinical medicine, Uromodulin/urine, kidney function, 11 Medical and Health Sciences, Genetics & Heredity, ddc:616, 0303 health sciences, Kidney, Genome-wide association, HERITABILITY, GENOME-WIDE ASSOCIATION, COMMON VARIANTS, RENAL-FUNCTION, TRANS-EQTLS, METAANALYSIS, TRANSPORTER, CLASSIFICATION, INTEGRATION, Chromosome Mapping, 3. Good health, Phenotype, medicine.anatomical_structure, Medical genetics, Common variants, Renal function, Trans-EQTLS, Metaanalysis, Heritability, Transporter, Life Sciences & Biomedicine, Glomerular Filtration Rate, Metaanalysi, medicine.medical_specialty, Genotype, European Continental Ancestry Group, Quantitative Trait Loci, Common variant, Quantitative trait locus, Biology, Polymorphism, Single Nucleotide, Article, White People, V. A. Million Veteran Program, 03 medical and health sciences, Quantitative Trait, Heritable, Lifelines Cohort Study, Uromodulin, Genetics, medicine, Humans, Genetic Predisposition to Disease, Renal Insufficiency, Chronic, Genetic Association Studies, 030304 developmental biology, Genetic association, Science & Technology, urogenital system, association, genetic loci, 06 Biological Sciences, medicine.disease, Renal Insufficiency, Chronic/genetics/physiopathology/urine, Genetic Association Studies/methods, ddc:000, 030217 neurology & neurosurgery, Developmental Biology, Genome-Wide Association Study, Kidney disease
Abstract

Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.

Published
2019
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282. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Author

Bentley, Amy R, Sung, Yun J, Brown, Michael R, Winkler, Thomas W, Kraja, Aldi T, Ntalla, Ioanna, Schwander, Karen, Chasman, Daniel I, Lim, Elise, Deng, Xuan, Guo, Xiuqing, Liu, Jingmin, Lu, Yingchang, Cheng, Ching-Yu, Sim, Xueling, Vojinovic, Dina, Huffman, Jennifer E, Musani, Solomon K, Li, Changwei, Feitosa, Mary F, Richard, Melissa A, Noordam, Raymond, Baker, Jenna, Chen, Guanjie, Aschard, Hugues, Bartz, Traci M, Ding, Jingzhong, Dorajoo, Rajkumar, Manning, Alisa K, Rankinen, Tuomo, Smith, Albert V, Tajuddin, Salman M, Zhao, Wei, Graff, Mariaelisa, Alver, Maris, Boissel, Mathilde, Chai, Jin Fang, Chen, Xu, Divers, Jasmin, Evangelou, Evangelos, Gao, Chuan, Goel, Anuj, Hagemeijer, Yanick, Harris, Sarah E, Hartwig, Fernando P, He, Meian, Horimoto, Andrea RVR, Hsu, Fang-Chi, Hung, Yi-Jen, Jackson, Anne U, Kasturiratne, Anuradhani, Komulainen, Pirjo, Kuehnel, Brigitte, Leander, Karin, Lin, Keng-Hung, Luan, Jian'an, Lyytikainen, Leo-Pekka, Matoba, Nana, Nolte, Ilja M, Pietzner, Maik, Prins, Bram, Riaz, Muhammad, Robino, Antonietta, Said, M Abdullah, Schupf, Nicole, Scott, Robert A, Sofer, Tamar, Stancakova, Alena, Takeuchi, Fumihiko, Tayo, Bamidele O, van der Most, Peter J, Varga, Tibor V, Wang, Tzung-Dau, Wang, Yajuan, Ware, Erin B, Wen, Wanqing, Xiang, Yong-Bing, Yanek, Lisa R, Zhang, Weihua, Zhao, Jing Hua, Adeyemo, Adebowale, Afaq, Saima, Amin, Najaf, Amini, Marzyeh, Arking, Dan E, Arzumanyan, Zorayr, Aung, Tin, Ballantyne, Christie, Barr, R Graham, Bielak, Lawrence F, Boerwinkle, Eric, Bottinger, Erwin P, Broeckel, Ulrich, Brown, Morris, Cade, Brian E, Campbell, Archie, Canouil, Mickael, Charumathi, Sabanayagam, Chen, Yii-Der Ida, Christensen, Kaare, Concas, Maria Pina, Connell, John M, de las Fuentes, Lisa, de Silva, H Janaka, de Vries, Paul S, Doumatey, Ayo, Duan, Qing, Eaton, Charles B, Eppinga, Ruben N, Faul, Jessica D, Floyd, James S, Forouhi, Nita G, Forrester, Terrence, Friedlander, Yechiel, Gandin, Ilaria, Gao, He, Ghanbari, Mohsen, Gharib, Sina A, Gigante, Bruna, Giulianini, Franco, Grabe, Hans J, Gu, C Charles, Harris, Tamara B, Heikkinen, Sami, Heng, Chew-Kiat, Hirata, Makoto, Hixson, James E, Ikram, M Arfan, Jia, Yucheng, Joehanes, Roby, Johnson, Craig, Jonas, Jost Bruno, Justice, Anne E, Katsuya, Tomohiro, Khor, Chiea Chuen, Kilpelainen, Tuomas O, Koh, Woon-Puay, Kolcic, Ivana, Kooperberg, Charles, Krieger, Jose E, Kritchevsky, Stephen B, Kubo, Michiaki, Kuusisto, Johanna, Lakka, Timo A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lehne, Benjamin, Lewis, Cora E, Li, Yize, Liang, Jingjing, Lin, Shiow, Liu, Ching-Ti, Liu, Jianjun, Liu, Kiang, Loh, Marie, Lohman, Kurt K, Louie, Tin, Luzzi, Anna, Magi, Reedik, Mahajan, Anubha, Manichaikul, Ani W, McKenzie, Colin A, Meitinger, Thomas, Metspalu, Andres, Milaneschi, Yuri, Milani, Lili, Mohlke, Karen L, Momozawa, Yukihide, Morris, Andrew P, Murray, Alison D, Nalls, Mike A, Nauck, Matthias, Nelson, Christopher P, North, Kari E, O'Connell, Jeffrey R, Palmer, Nicholette D, Papanicolau, George J, Pedersen, Nancy L, Peters, Annette, Peyser, Patricia A, Polasek, Ozren, Poulter, Neil, Raitakari, Olli T, Reiner, Alex P, Renstrom, Frida, Rice, Treva K, Rich, Stephen S, Robinson, Jennifer G, Rose, Lynda M, Rosendaal, Frits R, Rudan, Igor, Schmidt, Carsten O, Schreiner, Pamela J, Scott, William R, Sever, Peter, Shi, Yuan, Sidney, Stephen, Sims, Mario, Smith, Jennifer A, Snieder, Harold, Starr, John M, Strauch, Konstantin, Stringham, Heather M, Tan, Nicholas YQ, Tang, Hua, Taylor, Kent D, Teo, Yik Ying, Tham, Yih Chung, Tiemeier, Henning, Turner, Stephen T, Uitterlinden, Andre G, van Heemst, Diana, Waldenberger, Melanie, Wang, Heming, Wang, Lan, Wang, Lihua, Wei, Wen Bin, Williams, Christine A, Sr, Wilson Gregory, Wojczynski, Mary K, Yao, Jie, Young, Kristin, Yu, Caizheng, Yuan, Jian-Min, Zhou, Jie, Zonderman, Alan B, Becker, Diane M, Boehnke, Michael, Bowden, Donald W, Chambers, John C, Cooper, Richard S, de Faire, Ulf, Deary, Ian J, Elliott, Paul, Esko, Tonu, Farrall, Martin, Franks, Paul W, Freedman, Barry I, Froguel, Philippe, Gasparini, Paolo, Gieger, Christian, Horta, Bernardo L, Juang, Jyh-Ming Jimmy, Kamatani, Yoichiro, Kammerer, Candace M, Kato, Norihiro, Kooner, Jaspal S, Laakso, Markku, Laurie, Cathy C, Lee, I-Te, Lehtimaki, Terho, Magnusson, Patrik KE, Oldehinkel, Albertine J, Penninx, Brenda WJH, Pereira, Alexandre C, Rauramaa, Rainer, Redline, Susan, Samani, Nilesh J, Scott, James, Shu, Xiao-Ou, van der Harst, Pim, Wagenknecht, Lynne E, Wang, Jun-Sing, Wang, Ya Xing, Wareham, Nicholas J, Watkins, Hugh, Weir, David R, Wickremasinghe, Ananda R, Wu, Tangchun, Zeggini, Eleftheria, Zheng, Wei, Bouchard, Claude, Evans, Michele K, Gudnason, Vilmundur, Kardia, Sharon LR, Liu, Yongmei, Psaty, Bruce M, Ridker, Paul M, van Dam, Rob M, Mook-Kanamori, Dennis O, Fornage, Myriam, Province, Michael A, Kelly, Tanika N, Fox, Ervin R, Hayward, Caroline, van Duijn, Cornelia M, Tai, E Shyong, Wong, Tien Yin, Loos, Ruth JF, Franceschini, Nora, Rotter, Jerome I, Zhu, Xiaofeng, Bierut, Laura J, Gauderman, W James, Rice, Kenneth, Munroe, Patricia B, Morrison, Alanna C, Rao, Dabeeru C, Rotimi, Charles N, Cupples, L Adrienne, Consortium, COGENT-Kidney, Consortium, EPIC-InterAct, Grp, Understanding Soc Sci, Cohort, Lifelines, National Institutes of Health [Bethesda] (NIH), Washington University School of Medicine in St. Louis, Washington University in Saint Louis (WUSTL), The University of Texas Health Science Center at Houston (UTHealth), Universität Regensburg (UR), Queen Mary University of London (QMUL), Brigham and Women's Hospital [Boston], Harvard Medical School [Boston] (HMS), School of Public Health [Boston], Boston University [Boston] (BU), Los Angeles Biomedical Research Institute (LA BioMed), Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Singapore Eye Research Institute [Singapore] (SERI), Duke-NUS Medical School [Singapore], National University of Singapore (NUS), Erasmus University Medical Center [Rotterdam] (Erasmus MC), University of Edinburgh, University of Mississippi Medical Center (UMMC), University of Georgia [USA], Leiden University Medical Center (LUMC), Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Harvard T.H. Chan School of Public Health, University of Washington [Seattle], Wake Forest University, Genome Institute of Singapore (GIS), Massachusetts General Hospital [Boston], Pennington Biomedical Research Center, Louisiana State University (LSU), Icelandic Heart Association [Kopavogur, Iceland] (IHA), University of Iceland [Reykjavik], University of Michigan [Ann Arbor], University of Michigan System, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), University of Tartu, Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (GI3M), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Karolinska Institutet [Stockholm], Wake Forest School of Medicine [Winston-Salem], Wake Forest Baptist Medical Center, Imperial College London, University of Ioannina, University of Oxford [Oxford], University of Groningen [Groningen], Universidade Federal de Pelotas = Federal University of Pelotas (UFPel), University of Bristol [Bristol], Huazhong University of Science and Technology [Wuhan] (HUST), Universidade de São Paulo Medical School (FMUSP), Case Western Reserve University [Cleveland], University of Southern California (USC), This project was largely supported by a grant from the US National Heart, Lung, and Blood Institute of the National Institutes of Health (R01HL118305) and by the Intramural Research Program of the National Human Genome Research Institute of the National Institutes of Health through the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health (Z01HG200362)., Bentley, Ar, Sung, Yj, Brown, Mr, Winkler, Tw, Kraja, At, Ntalla, I, Schwander, K, Chasman, Di, Lim, E, Deng, X, Guo, X, Liu, J, Lu, Y, Cheng, Cy, Sim, X, Vojinovic, D, Huffman, Je, Musani, Sk, Li, C, Feitosa, Mf, Richard, Ma, Noordam, R, Baker, J, Chen, G, Aschard, H, Bartz, Tm, Ding, J, Dorajoo, R, Manning, Ak, Rankinen, T, Smith, Av, Tajuddin, Sm, Zhao, W, Graff, M, Alver, M, Boissel, M, Chai, Jf, Chen, X, Divers, J, Evangelou, E, Gao, C, Goel, A, Hagemeijer, Y, Harris, Se, Hartwig, Fp, He, M, Horimoto, Arvr, Hsu, Fc, Hung, Yj, Jackson, Au, Kasturiratne, A, Komulainen, P, Kühnel, B, Leander, K, Lin, Kh, Luan, J, Lyytikäinen, Lp, Matoba, N, Nolte, Im, Pietzner, M, Prins, B, Riaz, M, Robino, A, Said, Ma, Schupf, N, Scott, Ra, Sofer, T, Stancáková, A, Takeuchi, F, Tayo, Bo, van der Most, Pj, Varga, Tv, Wang, Td, Wang, Y, Ware, Eb, Wen, W, Xiang, Yb, Yanek, Lr, Zhang, W, Zhao, Jh, Adeyemo, A, Afaq, S, Amin, N, Amini, M, Arking, De, Arzumanyan, Z, Aung, T, Ballantyne, C, Barr, Rg, Bielak, Lf, Boerwinkle, E, Bottinger, Ep, Broeckel, U, Brown, M, Cade, Be, Campbell, A, Canouil, M, Charumathi, S, Chen, Yi, Christensen, K, COGENT-Kidney, Consortium, Concas, Mp, Connell, Jm, de Las Fuentes, L, de Silva, Hj, de Vries, P, Doumatey, A, Duan, Q, Eaton, Cb, Eppinga, Rn, Faul, Jd, Floyd, J, Forouhi, Ng, Forrester, T, Friedlander, Y, Gandin, I, Gao, H, Ghanbari, M, Gharib, Sa, Gigante, B, Giulianini, F, Grabe, Hj, Gu, Cc, Harris, Tb, Heikkinen, S, Heng, Ck, Hirata, M, Hixson, Je, Ikram, Ma, EPIC-InterAct, Consortium, Jia, Y, Joehanes, R, Johnson, C, Jonas, Jb, Justice, Ae, Katsuya, T, Khor, Cc, Kilpeläinen, To, Koh, Wp, Kolcic, I, Kooperberg, C, Krieger, Je, Kritchevsky, Sb, Kubo, M, Kuusisto, J, Lakka, Ta, Langefeld, Cd, Langenberg, C, Launer, Lj, Lehne, B, Lewis, Ce, Li, Y, Liang, J, Lin, S, Liu, Ct, Liu, K, Loh, M, Lohman, Kk, Louie, T, Luzzi, A, Mägi, R, Mahajan, A, Manichaikul, Aw, Mckenzie, Ca, Meitinger, T, Metspalu, A, Milaneschi, Y, Milani, L, Mohlke, Kl, Momozawa, Y, Morris, Ap, Murray, Ad, Nalls, Ma, Nauck, M, Nelson, Cp, North, Ke, O'Connell, Jr, Palmer, Nd, Papanicolau, Gj, Pedersen, Nl, Peters, A, Peyser, Pa, Polasek, O, Poulter, N, Raitakari, Ot, Reiner, Ap, Renström, F, Rice, Tk, Rich, S, Robinson, Jg, Rose, Lm, Rosendaal, Fr, Rudan, I, Schmidt, Co, Schreiner, Pj, Scott, Wr, Sever, P, Shi, Y, Sidney, S, Sims, M, Smith, Ja, Snieder, H, Starr, Jm, Strauch, K, Stringham, Hm, Tan, Nyq, Tang, H, Taylor, Kd, Teo, Yy, Tham, Yc, Tiemeier, H, Turner, St, Uitterlinden, Ag, Understanding Society Scientific, Group, van Heemst, D, Waldenberger, M, Wang, H, Wang, L, Wei, Wb, Williams, Ca, Wilson, G Sr, Wojczynski, Mk, Yao, J, Young, K, Yu, C, Yuan, Jm, Zhou, J, Zonderman, Ab, Becker, Dm, Boehnke, M, Bowden, Dw, Chambers, Jc, Cooper, R, de Faire, U, Deary, Ij, Elliott, P, Esko, T, Farrall, M, Franks, Pw, Freedman, Bi, Froguel, P, Gasparini, P, Gieger, C, Horta, Bl, Juang, Jj, Kamatani, Y, Kammerer, Cm, Kato, N, Kooner, J, Laakso, M, Laurie, Cc, Lee, It, Lehtimäki, T, Lifelines, Cohort, Magnusson, Pke, Oldehinkel, Aj, Penninx, Bwjh, Pereira, Ac, Rauramaa, R, Redline, S, Samani, Nj, Scott, J, Shu, Xo, van der Harst, P, Wagenknecht, Le, Wang, J, Wang, Yx, Wareham, Nj, Watkins, H, Weir, Dr, Wickremasinghe, Ar, Wu, T, Zeggini, E, Zheng, W, Bouchard, C, Evans, Mk, Gudnason, V, Kardia, Slr, Liu, Y, Psaty, Bm, Ridker, Pm, van Dam, Rm, Mook-Kanamori, Do, Fornage, M, Province, Ma, Kelly, Tn, Fox, Er, Hayward, C, van Duijn, Cm, Tai, E, Wong, Ty, Loos, Rjf, Franceschini, N, Rotter, Ji, Zhu, X, Bierut, Lj, Gauderman, Wj, Rice, K, Munroe, Pb, Morrison, Ac, Rao, Dc, Rotimi, Cn, Cupples, La., Luan, Jian'an [0000-0003-3137-6337], Pietzner, Maik [0000-0003-3437-9963], Zhao, Jing Hua [0000-0003-4930-3582], Forouhi, Nita [0000-0002-5041-248X], Langenberg, Claudia [0000-0002-5017-7344], Wareham, Nicholas [0000-0003-1422-2993], Apollo - University of Cambridge Repository, Epidemiology, Neurology, Radiology & Nuclear Medicine, Internal Medicine, Life Course Epidemiology (LCE), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Cardiovascular Centre (CVC), Home Office, Action on Hearing Loss, Imperial College Healthcare NHS Trust- BRC Funding, Medical Research Council (MRC), Universiteit Leiden, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (EGENODIA (GI3M)), University of Oxford, Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, APH - Mental Health, and APH - Digital Health

Subjects
Male, Linkage disequilibrium, Blood lipids, Genome-wide association study, VARIANTS, SUSCEPTIBILITY, Environment interaction, Genome, Linkage Disequilibrium, MESH: Genotype, 0302 clinical medicine, MESH: Aged, 80 and over, Genotype, NICOTINE METABOLISM, 11 Medical and Health Sciences, Genetics & Heredity, Aged, 80 and over, Genetics, MESH: Aged, 0303 health sciences, ARCHITECTURE, [STAT.AP]Statistics [stat]/Applications [stat.AP], Genotype imputation, MESH: Middle Aged, CHOLESTEROL, Smoking, MESH: Life Style, Lifelines Cohort, Middle Aged, Lipids, 3. Good health, ENVIRONMENT INTERACTION, GENOTYPE IMPUTATION, RISK LOCI, METAANALYSIS, CIGARETTES, Cholesterol, MESH: Linkage Disequilibrium, MESH: Young Adult, Meta-analysis, Genome-Wide Association Study/methods, Smoking/blood, Medical genetics, Female, EPIC-InterAct Consortium, Life Sciences & Biomedicine, [STAT.ME]Statistics [stat]/Methodology [stat.ME], Adult, Metaanalysi, Understanding Society Scientific Group, medicine.medical_specialty, MESH: Smoking, Adolescent, Genomics, COGENT-Kidney Consortium, Biology, Nicotine metabolism, Risk loci, Metaanalysis, Cigarettes, Article, Young Adult, 03 medical and health sciences, genomics, medicine, Humans, Linkage Disequilibrium/genetics, Life Style, Aged, 030304 developmental biology, MESH: Adolescent, Science & Technology, MESH: Humans, Lipids/blood, MESH: Adult, 06 Biological Sciences, MESH: Lipids, MESH: Male, cardiovascular diseases, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, genome-wide association studies, MESH: Genome-Wide Association Study, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], MESH: Female, 030217 neurology & neurosurgery, Developmental Biology, Genome-Wide Association Study
Abstract

The concentrations of high- and low-density lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 novel loci, some of which were detected only because the association differed by smoking status. Additionally, we demonstrated the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings., Editorial summary: A multi-ancestry genome-wide gene-smoking interaction study identifies 13 new loci associated with serum lipids.

Published
2019
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284. Practice Patterns and Challenges in Managing Inherited Retinal Diseases Across Asia-Pacific: A Survey from the APIED Network

Author

Wong, Wendy M., Tham, Yih Chung, Ayton, Lauren N., Britten-Jones, Alexis Ceecee, Edwards, Thomas L., Grigg, John, Simunovic, Matthew P., Chen, Fred K., Jin, Zi-Bing, Shen, Ren-Juan, Sui, Ruifang, Yang, Liping, Zhao, Chen, Chen, Haoyu, Li, Shiying, Ding, Xiaoyan, Bhende, Muna, Raman, Rajiv, Sen, Parveen, Poornachandra, B., Chia, Valen, Manurung, Florence, Sasongko, Muhammad Bayu, Ikeda, Hanako, Fujinami, Kaoru, Woo, Se Joon, Kim, Sang Jin, Bastion, Mae-Lynn Catherine, Kamalden, Ain Tengku, Lott, Penny P., Fong, Kenneth, Shunmugam, Manoharan, Lim, Amelia, Thapa, Raba, Ibañez, B.Manuel Benjamin, Koh, Adrian, Holder, Graham E., Su, Xinyi, Chan, Choi Mun, Fenner, Beau J., Laude, Augustinus, Ngo, Wei Kiong, Chen, Ta-Ching, Wang, Nan-Kai, Kang, Eugene Yu-Chuan, Surawatsatien, Nuntachai, Pisuchpen, Phattrawan, Sujirakul, Tharikarn, Wongchaisuwat, Nida, Apivatthakakul, Atitaya, Kumaramanickavel, Govindasamy, Leroy, Bart, Michaelides, Michel, Pontikos, Nikolas, Cheng, Ching-Yu, Pang, Chi Pui, Chen, Li Jia, and Chan, Hwei Wuen

Abstract

The objective of this paper is to shed light on the current landscape of genotyping practices, phenotyping practices and availability of essential vision rehabilitation management for inherited retinal diseases (IRD) in the Asia-Pacific (APAC) Region.

Published
2024
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285. Global Prevalence of Diabetic Retinopathy and Projection of Burden through 2045: Systematic Review and Meta-analysis.

Author

Teo, Zhen Ling, Tham, Yih-Chung, Yu, Marco, Chee, Miao Li, Rim, Tyler Hyungtaek, Cheung, Ning, Bikbov, Mukharram M., Wang, Ya Xing, Tang, Yating, Lu, Yi, Wong, Ian Y., Ting, Daniel Shu Wei, Tan, Gavin Siew Wei, Jonas, Jost B., Sabanayagam, Charumathi, Wong, Tien Yin, and Cheng, Ching-Yu

Subjects
*DIABETIC retinopathy, *LOGITS, *MACULAR edema, *ADULTS, *DIABETES
Abstract

To provide updated estimates on the global prevalence and number of people with diabetic retinopathy (DR) through 2045. The International Diabetes Federation (IDF) estimated the global population with diabetes mellitus (DM) to be 463 million in 2019 and 700 million in 2045. Diabetic retinopathy remains a common complication of DM and a leading cause of preventable blindness in the adult working population. We conducted a systematic review using PubMed, Medline, Web of Science, and Scopus for population-based studies published up to March 2020. Random effect meta-analysis with logit transformation was performed to estimate global and regional prevalence of DR, vision-threatening DR (VTDR), and clinically significant macular edema (CSME). Projections of DR, VTDR, and CSME burden were based on population data from the IDF Atlas 2019. We included 59 population-based studies. Among individuals with diabetes, global prevalence was 22.27% (95% confidence interval [CI], 19.73%–25.03%) for DR, 6.17% (95% CI, 5.43%–6.98%) for VTDR, and 4.07% (95% CI, 3.42%–4.82%) for CSME. In 2020, the number of adults worldwide with DR, VTDR, and CSME was estimated to be 103.12 million, 28.54 million, and 18.83 million, respectively; by 2045, the numbers are projected to increase to 160.50 million, 44.82 million, and 28.61 million, respectively. Diabetic retinopathy prevalence was highest in Africa (35.90%) and North American and the Caribbean (33.30%) and was lowest in South and Central America (13.37%). In meta-regression models adjusting for habitation type, response rate, study year, and DR diagnostic method, Hispanics (odds ratio [OR], 2.92; 95% CI, 1.22–6.98) and Middle Easterners (OR, 2.44; 95% CI, 1.51–3.94) with diabetes were more likely to have DR compared with Asians. The global DR burden is expected to remain high through 2045, disproportionately affecting countries in the Middle East and North Africa and the Western Pacific. These updated estimates may guide DR screening, treatment, and public health care strategies. [ABSTRACT FROM AUTHOR]

Published
2021
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288. Cataract Surgery and the 6-year Incidence of Age-Related Macular Degeneration in a Multiethnic Asian Cohort

Author

Gan, Alfred TL, primary, Man, Ryan EK, additional, Cheung, Chui Ming Gemmy, additional, Kumari, Neelam, additional, Fenwick, Eva K, additional, Sabanayagam, Charumathi, additional, Tham, Yih-Chung, additional, Tan, Nicholas YQ, additional, Mitchell, Paul, additional, Wong, Tien Yin, additional, Cheng, Ching-Yu, additional, and Lamoureux, Ecosse L, additional

Published
2020
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289. Is kidney function associated with primary open-angle glaucoma? Findings from the Asian Eye Epidemiology Consortium

Author

Tham, Yih-Chung, primary, Tao, Yijin, additional, Zhang, Liang, additional, Rim, Tyler Hyung Taek, additional, Thakur, Sahil, additional, Lim, Zhi Wei, additional, Chee, Miao Li, additional, Bikbov, Mukharram M, additional, Kazakbaeva, Gyulli M, additional, Wang, Ningli, additional, Cao, Kai, additional, Hao, Jie, additional, Nangia, Vinay, additional, Panda-Jonas, Songhomitra, additional, Wang, Ya Xing, additional, Wong, Ian Y, additional, Chan, Jonathan Cheuk Hung, additional, Meng, Qianli, additional, Sabanayagam, Charumathi, additional, Wong, Tien Y, additional, Jonas, Jost B, additional, Zhong, Hua, additional, and Cheng, Ching-Yu, additional

Published
2020
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291. Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Author

Iglesias, Adriana I, Mishra, Aniket, Vitart, Veronique, Bykhovskaya, Yelena, Höhn, René, Springelkamp, Henriët, Cuellar-Partida, Gabriel, Gharahkhani, Puya, Bailey, Jessica N Cooke, Willoughby, Colin E, Li, Xiaohui, Yazar, Seyhan, Nag, Abhishek, Khawaja, Anthony P, Polašek, Ozren, Siscovick, David, Mitchell, Paul, Tham, Yih Chung, Haines, Jonathan L, Kearns, Lisa S, Hayward, Caroline, Shi, Yuan, van Leeuwen, Elisabeth M, Taylor, Kent D, Blue Mountains Eye Study—GWAS group, Bonnemaijer, Pieter, Rotter, Jerome I, Martin, Nicholas G, Zeller, Tanja, Mills, Richard A, Souzeau, Emmanuelle, Staffieri, Sandra E, Jonas, Jost B, Schmidtmann, Irene, Boutin, Thibaud, Kang, Jae H, Lucas, Sionne EM, Wong, Tien Yin, Beutel, Manfred E, Wilson, James F, NEIGHBORHOOD Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), Uitterlinden, André G, Vithana, Eranga N, Foster, Paul J, Hysi, Pirro G, Hewitt, Alex W, Khor, Chiea Chuen, Pasquale, Louis R, Montgomery, Grant W, Klaver, Caroline CW, Aung, Tin, Pfeiffer, Norbert, Mackey, David A, Hammond, Christopher J, Cheng, Ching-Yu, Craig, Jamie E, Rabinowitz, Yaron S, Wiggs, Janey L, Burdon, Kathryn P, van Duijn, Cornelia M, and MacGregor, Stuart

Subjects
Asian Continental Ancestry Group, Lumican, genetic structures, Corneal Dystrophies, Eye Diseases, Fibrillin-1, 1.1 Normal biological development and functioning, European Continental Ancestry Group, Quantitative Trait Loci, Gene Expression, Keratoconus, Eye, White People, Marfan Syndrome, Corneal Diseases, Cornea, Quantitative Trait, Transforming Growth Factor beta2, ADAMTS Proteins, Rare Diseases, Asian People, Underpinning research, Blue Mountains Eye Study—GWAS group, Myopia, Genetics, Humans, Polymorphism, Heritable, Eye Disease and Disorders of Vision, Loeys-Dietz Syndrome, Genome, NEIGHBORHOOD Consortium, Wellcome Trust Case Control Consortium 2, Human Genome, Glaucoma, Single Nucleotide, Mendelian Randomization Analysis, eye diseases, Hereditary, Open-Angle, Ehlers-Danlos Syndrome, Proteoglycans, sense organs, Decorin, Human, Genome-Wide Association Study
Abstract

Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana. Using index CCT-increasing variants, we find a significant inverse correlation in effect sizes between CCT and keratoconus (r = -0.62, P = 5.30 × 10-5) but not between CCT and primary open-angle glaucoma (r = -0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation.

Published
2018

292. Age-related changes of individual macular retinal layers among Asians

Author

Chua, Jacqueline, primary, Tham, Yih Chung, additional, Tan, Bingyao, additional, Devarajan, Kavya, additional, Schwarzhans, Florian, additional, Gan, Alfred, additional, Wong, Damon, additional, Cheung, Carol Y., additional, Majithia, Shivani, additional, Thakur, Sahil, additional, Fischer, Georg, additional, Vass, Clemens, additional, Cheng, Ching-Yu, additional, and Schmetterer, Leopold, additional

Published
2019
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295. Associations of autozygosity with a broad range of human phenotypes

Author

Clark, David W, primary, Okada, Yukinori, additional, Moore, Kristjan H S, additional, Mason, Dan, additional, Pirastu, Nicola, additional, Gandin, Ilaria, additional, Mattsson, Hannele, additional, Barnes, Catriona L K, additional, Lin, Kuang, additional, Zhao, Jing Hua, additional, Deelen, Patrick, additional, Rohde, Rebecca, additional, Schurmann, Claudia, additional, Guo, Xiuqing, additional, Giulianini, Franco, additional, Zhang, Weihua, additional, Medina-Gomez, Carolina, additional, Karlsson, Robert, additional, Bao, Yanchun, additional, Bartz, Traci M, additional, Baumbach, Clemens, additional, Biino, Ginevra, additional, Bixley, Matthew J, additional, Brumat, Marco, additional, Chai, Jin-Fang, additional, Corre, Tanguy, additional, Cousminer, Diana L, additional, Dekker, Annelot M, additional, Eccles, David A, additional, van Eijk, Kristel R, additional, Fuchsberger, Christian, additional, Gao, He, additional, Germain, Marine, additional, Gordon, Scott D, additional, de Haan, Hugoline G, additional, Harris, Sarah E, additional, Hofer, Edith, additional, Huerta-Chagoya, Alicia, additional, Igartua, Catherine, additional, Jansen, Iris E, additional, Jia, Yucheng, additional, Kacprowski, Tim, additional, Karlsson, Torgny, additional, Kleber, Marcus E, additional, Li, Shengchao Alfred, additional, Li-Gao, Ruifang, additional, Mahajan, Anubha, additional, Matsuda, Koichi, additional, Meidtner, Karina, additional, Meng, Weihua, additional, Montasser, May E, additional, van der Most, Peter J, additional, Munz, Matthias, additional, Nutile, Teresa, additional, Palviainen, Teemu, additional, Prasad, Gauri, additional, Prasad, Rashmi B, additional, Priyanka, Tallapragada Divya Sri, additional, Rizzi, Federica, additional, Salvi, Erika, additional, Sapkota, Bishwa R, additional, Shriner, Daniel, additional, Skotte, Line, additional, Smart, Melissa C, additional, Smith, Albert Vernon, additional, van der Spek, Ashley, additional, Spracklen, Cassandra N, additional, Strawbridge, Rona J, additional, Tajuddin, Salman M, additional, Trompet, Stella, additional, Turman, Constance, additional, Verweij, Niek, additional, Viberti, Clara, additional, Wang, Lihua, additional, Warren, Helen R, additional, Wootton, Robyn E, additional, Yanek, Lisa R, additional, Yao, Jie, additional, Yousri, Noha A, additional, Zhao, Wei, additional, Adeyemo, Adebowale A, additional, Afaq, Saima, additional, Aguilar-Salinas, Carlos Alberto, additional, Akiyama, Masato, additional, Albert, Matthew L, additional, Allison, Matthew A, additional, Alver, Maris, additional, Aung, Tin, additional, Azizi, Fereidoun, additional, Bentley, Amy R, additional, Boeing, Heiner, additional, Boerwinkle, Eric, additional, Borja, Judith B, additional, de Borst, Gert J, additional, Bottinger, Erwin P, additional, Broer, Linda, additional, Campbell, Harry, additional, Chanock, Stephen, additional, Chee, Miao-Li, additional, Chen, Guanjie, additional, Chen, Yii-Der I, additional, Chen, Zhengming, additional, Chiu, Yen-Feng, additional, Cocca, Massimiliano, additional, Collins, Francis S, additional, Concas, Maria Pina, additional, Corley, Janie, additional, Cugliari, Giovanni, additional, van Dam, Rob M, additional, Damulina, Anna, additional, Daneshpour, Maryam S, additional, Day, Felix R, additional, Delgado, Graciela E, additional, Dhana, Klodian, additional, Doney, Alexander S F, additional, Dörr, Marcus, additional, Doumatey, Ayo P, additional, Dzimiri, Nduna, additional, Ebenesersdóttir, S Sunna, additional, Elliott, Joshua, additional, Elliott, Paul, additional, Ewert, Ralf, additional, Felix, Janine F, additional, Fischer, Krista, additional, Freedman, Barry I, additional, Girotto, Giorgia, additional, Goel, Anuj, additional, Gögele, Martin, additional, Goodarzi, Mark O, additional, Graff, Mariaelisa, additional, Granot-Hershkovitz, Einat, additional, Grodstein, Francine, additional, Guarrera, Simonetta, additional, Gudbjartsson, Daniel F, additional, Guity, Kamran, additional, Gunnarsson, Bjarni, additional, Guo, Yu, additional, Hagenaars, Saskia P, additional, Haiman, Christopher A, additional, Halevy, Avner, additional, Harris, Tamara B, additional, Hedayati, Mehdi, additional, van Heel, David A, additional, Hirata, Makoto, additional, Höfer, Imo, additional, Hsiung, Chao Agnes, additional, Huang, Jinyan, additional, Hung, Yi-Jen, additional, Ikram, M Arfan, additional, Jagadeesan, Anuradha, additional, Jousilahti, Pekka, additional, Kamatani, Yoichiro, additional, Kanai, Masahiro, additional, Kerrison, Nicola D, additional, Kessler, Thorsten, additional, Khaw, Kay-Tee, additional, Khor, Chiea Chuen, additional, de Kleijn, Dominique P V, additional, Koh, Woon-Puay, additional, Kolcic, Ivana, additional, Kraft, Peter, additional, Krämer, Bernhard K, additional, Kutalik, Zoltán, additional, Kuusisto, Johanna, additional, Langenberg, Claudia, additional, Launer, Lenore J, additional, Lawlor, Deborah A, additional, Lee, I-Te, additional, Lee, Wen-Jane, additional, Lerch, Markus M, additional, Li, Liming, additional, Liu, Jianjun, additional, Loh, Marie, additional, London, Stephanie J, additional, Loomis, Stephanie, additional, Lu, Yingchang, additional, Luan, Jian’an, additional, Mägi, Reedik, additional, Manichaikul, Ani W, additional, Manunta, Paolo, additional, Másson, Gísli, additional, Matoba, Nana, additional, Mei, Xue W, additional, Meisinger, Christa, additional, Meitinger, Thomas, additional, Mezzavilla, Massimo, additional, Milani, Lili, additional, Millwood, Iona Y, additional, Momozawa, Yukihide, additional, Moore, Amy, additional, Morange, Pierre-Emmanuel, additional, Moreno-Macías, Hortensia, additional, Mori, Trevor A, additional, Morrison, Alanna C, additional, Muka, Taulant, additional, Murakami, Yoshinori, additional, Murray, Alison D, additional, de Mutsert, Renée, additional, Mychaleckyj, Josyf C, additional, Nalls, Mike A, additional, Nauck, Matthias, additional, Neville, Matt J, additional, Nolte, Ilja M, additional, Ong, Ken K, additional, Orozco, Lorena, additional, Padmanabhan, Sandosh, additional, Pálsson, Gunnar, additional, Pankow, James S, additional, Pattaro, Cristian, additional, Pattie, Alison, additional, Polasek, Ozren, additional, Poulter, Neil, additional, Pramstaller, Peter P, additional, Quintana-Murci, Lluis, additional, Räikkönen, Katri, additional, Ralhan, Sarju, additional, Rao, Dabeeru C, additional, van Rheenen, Wouter, additional, Rich, Stephen S, additional, Ridker, Paul M, additional, Rietveld, Cornelius A, additional, Robino, Antonietta, additional, van Rooij, Frank J A, additional, Ruggiero, Daniela, additional, Saba, Yasaman, additional, Sabanayagam, Charumathi, additional, Sabater-Lleal, Maria, additional, Sala, Cinzia Felicita, additional, Salomaa, Veikko, additional, Sandow, Kevin, additional, Schmidt, Helena, additional, Scott, Laura J, additional, Scott, William R, additional, Sedaghati-Khayat, Bahareh, additional, Sennblad, Bengt, additional, van Setten, Jessica, additional, Sever, Peter J, additional, Sheu, Wayne H-H, additional, Shi, Yuan, additional, Shrestha, Smeeta, additional, Shukla, Sharvari Rahul, additional, Sigurdsson, Jon K, additional, Sikka, Timo Tonis, additional, Singh, Jai Rup, additional, Smith, Blair H, additional, Stančáková, Alena, additional, Stanton, Alice, additional, Starr, John M, additional, Stefansdottir, Lilja, additional, Straker, Leon, additional, Sulem, Patrick, additional, Sveinbjornsson, Gardar, additional, Swertz, Morris A, additional, Taylor, Adele M, additional, Taylor, Kent D, additional, Terzikhan, Natalie, additional, Tham, Yih-Chung, additional, Thorleifsson, Gudmar, additional, Thorsteinsdottir, Unnur, additional, Tillander, Annika, additional, Tracy, Russell P, additional, Tusié-Luna, Teresa, additional, Tzoulaki, Ioanna, additional, Vaccargiu, Simona, additional, Vangipurapu, Jagadish, additional, Veldink, Jan H, additional, Vitart, Veronique, additional, Völker, Uwe, additional, Vuoksimaa, Eero, additional, Wakil, Salma M, additional, Waldenberger, Melanie, additional, Wander, Gurpreet S, additional, Wang, Ya Xing, additional, Wareham, Nicholas J, additional, Wild, Sarah, additional, Yajnik, Chittaranjan S, additional, Yuan, Jian-Min, additional, Zeng, Lingyao, additional, Zhang, Liang, additional, Zhou, Jie, additional, Amin, Najaf, additional, Asselbergs, Folkert W, additional, Bakker, Stephan J L, additional, Becker, Diane M, additional, Lehne, Benjamin, additional, Bennett, David A, additional, van den Berg, Leonard H, additional, Berndt, Sonja I, additional, Bharadwaj, Dwaipayan, additional, Bielak, Lawrence F, additional, Bochud, Murielle, additional, Boehnke, Mike, additional, Bouchard, Claude, additional, Bradfield, Jonathan P, additional, Brody, Jennifer A, additional, Campbell, Archie, additional, Carmi, Shai, additional, Caulfield, Mark J, additional, Cesarini, David, additional, Chambers, John C, additional, Chandak, Giriraj Ratan, additional, Cheng, Ching-Yu, additional, Ciullo, Marina, additional, Cornelis, Marilyn, additional, Cusi, Daniele, additional, Smith, George Davey, additional, Deary, Ian J, additional, Dorajoo, Rajkumar, additional, van Duijn, Cornelia M, additional, Ellinghaus, David, additional, Erdmann, Jeanette, additional, Eriksson, Johan G, additional, Evangelou, Evangelos, additional, Evans, Michele K, additional, Faul, Jessica D, additional, Feenstra, Bjarke, additional, Feitosa, Mary, additional, Foisy, Sylvain, additional, Franke, Andre, additional, Friedlander, Yechiel, additional, Gasparini, Paolo, additional, Gieger, Christian, additional, Gonzalez, Clicerio, additional, Goyette, Philippe, additional, Grant, Struan F A, additional, Griffiths, Lyn R, additional, Groop, Leif, additional, Gudnason, Vilmundur, additional, Gyllensten, Ulf, additional, Hakonarson, Hakon, additional, Hamsten, Anders, additional, van der Harst, Pim, additional, Heng, Chew-Kiat, additional, Hicks, Andrew A, additional, Hochner, Hagit, additional, Huikuri, Heikki, additional, Hunt, Steven C, additional, Jaddoe, Vincent W V, additional, De Jager, Philip L, additional, Johannesson, Magnus, additional, Johansson, Åsa, additional, Jonas, Jost B, additional, Jukema, J Wouter, additional, Junttila, Juhani, additional, Kaprio, Jaakko, additional, Kardia, Sharon L. R., additional, Karpe, Fredrik, additional, Kumari, Meena, additional, Laakso, Markku, additional, van der Laan, Sander W, additional, Lahti, Jari, additional, Laudes, Matthias, additional, Lea, Rodney A, additional, Lieb, Wolfgang, additional, Lumley, Thomas, additional, Martin, Nicholas G, additional, März, Winfried, additional, Matullo, Giuseppe, additional, McCarthy, Mark I, additional, Medland, Sarah E, additional, Merriman, Tony R, additional, Metspalu, Andres, additional, Meyer, Brian F, additional, Mohlke, Karen L, additional, Montgomery, Grant W, additional, Mook-Kanamori, Dennis, additional, Munroe, Patricia B, additional, North, Kari E, additional, Nyholt, Dale R, additional, O’connell, Jeffery R, additional, Ober, Carole, additional, Oldehinkel, Albertine J, additional, Palmas, Walter, additional, Palmer, Colin, additional, Pasterkamp, Gerard G, additional, Patin, Etienne, additional, Pennell, Craig E, additional, Perusse, Louis, additional, Peyser, Patricia A, additional, Pirastu, Mario, additional, Polderman, Tinca J. C., additional, Porteous, David J, additional, Posthuma, Danielle, additional, Psaty, Bruce M, additional, Rioux, John D, additional, Rivadeneira, Fernando, additional, Rotimi, Charles, additional, Rotter, Jerome I, additional, Rudan, Igor, additional, Den Ruijter, Hester M, additional, Sanghera, Dharambir K, additional, Sattar, Naveed, additional, Schmidt, Reinhold, additional, Schulze, Matthias B, additional, Schunkert, Heribert, additional, Scott, Robert A, additional, Shuldiner, Alan R, additional, Sim, Xueling, additional, Small, Neil, additional, Smith, Jennifer A, additional, Sotoodehnia, Nona, additional, Tai, E-Shyong, additional, Teumer, Alexander, additional, Timpson, Nicholas J, additional, Toniolo, Daniela, additional, Tregouet, David-Alexandre, additional, Tuomi, Tiinamaija, additional, Vollenweider, Peter, additional, Wang, Carol A, additional, Weir, David R, additional, Whitfield, John B, additional, Wijmenga, Cisca, additional, Wong, Tien-Yin, additional, Wright, John, additional, Yang, Jingyun, additional, Yu, Lei, additional, Zemel, Babette S, additional, Zonderman, Alan B, additional, Perola, Markus, additional, Magnusson, Patrik K. E., additional, Uitterlinden, André G, additional, Kooner, Jaspal S, additional, Chasman, Daniel I, additional, Loos, Ruth J. F., additional, Franceschini, Nora, additional, Franke, Lude, additional, Haley, Chris S, additional, Hayward, Caroline, additional, Walters, Robin G, additional, Perry, John R. B., additional, Esko, Tōnu, additional, Helgason, Agnar, additional, Stefansson, Kari, additional, Joshi, Peter K, additional, Kubo, Michiaki, additional, and Wilson, James F, additional

Published
2019
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297. Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore

Author

Wu, Degang, primary, Dou, Jinzhuang, additional, Chai, Xiaoran, additional, Bellis, Claire, additional, Wilm, Andreas, additional, Shih, Chih Chuan, additional, Soon, Wendy Wei Jia, additional, Bertin, Nicolas, additional, Lin, Clarabelle Bitong, additional, Khor, Chiea Chuen, additional, DeGiorgio, Michael, additional, Cheng, Shanshan, additional, Bao, Li, additional, Karnani, Neerja, additional, Hwang, William Ying Khee, additional, Davila, Sonia, additional, Tan, Patrick, additional, Shabbir, Asim, additional, Moh, Angela, additional, Tan, Eng-King, additional, Foo, Jia Nee, additional, Goh, Liuh Ling, additional, Leong, Khai Pang, additional, Foo, Roger S.Y., additional, Lam, Carolyn Su Ping, additional, Richards, Arthur Mark, additional, Cheng, Ching-Yu, additional, Aung, Tin, additional, Wong, Tien Yin, additional, Ng, Huck Hui, additional, Liu, Jianjun, additional, Wang, Chaolong, additional, Ackers-Johnson, Matthew Andrew, additional, Aliwarga, Edita, additional, Ban, Kenneth Hon Kim, additional, Bertrand, Denis, additional, Chambers, John C., additional, Chan, Dana Leng Hui, additional, Chan, Cheryl Xue Li, additional, Chee, Miao Li, additional, Chee, Miao Ling, additional, Chen, Pauline, additional, Chen, Yunxin, additional, Chew, Elaine Guo Yan, additional, Chew, Wen Jie, additional, Chiam, Lynn Hui Yun, additional, Chong, Jenny Pek Ching, additional, Chua, Ivan, additional, Cook, Stuart A., additional, Dai, Wei, additional, Dorajoo, Rajkumar, additional, Foo, Chuan-Sheng, additional, Goh, Rick Siow Mong, additional, Hillmer, Axel M., additional, Irwan, Ishak D., additional, Jaufeerally, Fazlur, additional, Javed, Asif, additional, Jeyakani, Justin, additional, Koh, John Tat Hung, additional, Koh, Jia Yu, additional, Krishnaswamy, Pavitra, additional, Kuan, Jyn Ling, additional, Kumari, Neelam, additional, Lee, Ai Shan, additional, Lee, Seow Eng, additional, Lee, Sheldon, additional, Lee, Yen Ling, additional, Leong, See Ting, additional, Li, Zheng, additional, Li, Peter Yiqing, additional, Liew, Jun Xian, additional, Liew, Oi Wah, additional, Lim, Su Chi, additional, Lim, Weng Khong, additional, Lim, Chia Wei, additional, Lim, Tingsen Benson, additional, Lim, Choon Kiat, additional, Loh, Seet Yoong, additional, Lok, Au Wing, additional, Chin, Calvin W.L., additional, Majithia, Shivani, additional, Maurer-Stroh, Sebastian, additional, Meah, Wee Yang, additional, Mok, Shi Qi, additional, Nargarajan, Niranjan, additional, Ng, Pauline, additional, Ng, Sarah B., additional, Ng, Zhenyuan, additional, Ng, Jessica Yan Xia, additional, Ng, Ebonne, additional, Ng, Shi Ling, additional, Nusinovici, Simon, additional, Ong, Chin Thing, additional, Pan, Bangfen, additional, Pedergnana, Vincent, additional, Poh, Stanley, additional, Prabhakar, Shyam, additional, Prakash, Kumar M., additional, Quek, Ivy, additional, Sabanayagam, Charumathi, additional, See, Wei Qiang, additional, Sia, Yee Yen, additional, Sim, Xueling, additional, Sim, Wey Cheng, additional, So, Jimmy, additional, Soon, Dinna K.N., additional, Tai, E. Shyong, additional, Tan, Nicholas Y., additional, Tan, Louis C.S., additional, Tan, Hong Chang, additional, Tan, Wilson Lek Wen, additional, Tandiono, Moses, additional, Tay, Amanda, additional, Thakur, Sahil, additional, Tham, Yih Chung, additional, Tiang, Zenia, additional, Toh, Grace Li-Xian, additional, Tsai, Pi Kuang, additional, Veeravalli, Lavanya, additional, Verma, Chandra S., additional, Wang, Ling, additional, Wang, Min Rui, additional, Wong, Wing-Cheong, additional, Xie, Zhicheng, additional, Yeo, Khung Keong, additional, Zhang, Liang, additional, Zhai, Weiwei, additional, and Zhao, Yi, additional

Published
2019
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299. Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

Author

Teumer, Alexander, primary, Li, Yong, additional, Ghasemi, Sahar, additional, Prins, Bram P., additional, Wuttke, Matthias, additional, Hermle, Tobias, additional, Giri, Ayush, additional, Sieber, Karsten B., additional, Qiu, Chengxiang, additional, Kirsten, Holger, additional, Tin, Adrienne, additional, Chu, Audrey Y., additional, Bansal, Nisha, additional, Feitosa, Mary F., additional, Wang, Lihua, additional, Chai, Jin-Fang, additional, Cocca, Massimiliano, additional, Fuchsberger, Christian, additional, Gorski, Mathias, additional, Hoppmann, Anselm, additional, Horn, Katrin, additional, Li, Man, additional, Marten, Jonathan, additional, Noce, Damia, additional, Nutile, Teresa, additional, Sedaghat, Sanaz, additional, Sveinbjornsson, Gardar, additional, Tayo, Bamidele O., additional, van der Most, Peter J., additional, Xu, Yizhe, additional, Yu, Zhi, additional, Gerstner, Lea, additional, Ärnlöv, Johan, additional, Bakker, Stephan J. L., additional, Baptista, Daniela, additional, Biggs, Mary L., additional, Boerwinkle, Eric, additional, Brenner, Hermann, additional, Burkhardt, Ralph, additional, Carroll, Robert J., additional, Chee, Miao-Li, additional, Chee, Miao-Ling, additional, Chen, Mengmeng, additional, Cheng, Ching-Yu, additional, Cook, James P., additional, Coresh, Josef, additional, Corre, Tanguy, additional, Danesh, John, additional, de Borst, Martin H., additional, De Grandi, Alessandro, additional, de Mutsert, Renée, additional, de Vries, Aiko P. J., additional, Degenhardt, Frauke, additional, Dittrich, Katalin, additional, Divers, Jasmin, additional, Eckardt, Kai-Uwe, additional, Ehret, Georg, additional, Endlich, Karlhans, additional, Felix, Janine F., additional, Franco, Oscar H., additional, Franke, Andre, additional, Freedman, Barry I., additional, Freitag-Wolf, Sandra, additional, Gansevoort, Ron T., additional, Giedraitis, Vilmantas, additional, Gögele, Martin, additional, Grundner-Culemann, Franziska, additional, Gudbjartsson, Daniel F., additional, Gudnason, Vilmundur, additional, Hamet, Pavel, additional, Harris, Tamara B., additional, Hicks, Andrew A., additional, Holm, Hilma, additional, Foo, Valencia Hui Xian, additional, Hwang, Shih-Jen, additional, Ikram, M. Arfan, additional, Ingelsson, Erik, additional, Jaddoe, Vincent W. V., additional, Jakobsdottir, Johanna, additional, Josyula, Navya Shilpa, additional, Jung, Bettina, additional, Kähönen, Mika, additional, Khor, Chiea-Chuen, additional, Kiess, Wieland, additional, Koenig, Wolfgang, additional, Körner, Antje, additional, Kovacs, Peter, additional, Kramer, Holly, additional, Krämer, Bernhard K., additional, Kronenberg, Florian, additional, Lange, Leslie A., additional, Langefeld, Carl D., additional, Lee, Jeannette Jen-Mai, additional, Lehtimäki, Terho, additional, Lieb, Wolfgang, additional, Lim, Su-Chi, additional, Lind, Lars, additional, Lindgren, Cecilia M., additional, Liu, Jianjun, additional, Loeffler, Markus, additional, Lyytikäinen, Leo-Pekka, additional, Mahajan, Anubha, additional, Maranville, Joseph C., additional, Mascalzoni, Deborah, additional, McMullen, Barbara, additional, Meisinger, Christa, additional, Meitinger, Thomas, additional, Miliku, Kozeta, additional, Mook-Kanamori, Dennis O., additional, Müller-Nurasyid, Martina, additional, Mychaleckyj, Josyf C., additional, Nauck, Matthias, additional, Nikus, Kjell, additional, Ning, Boting, additional, Noordam, Raymond, additional, Connell, Jeffrey O’, additional, Olafsson, Isleifur, additional, Palmer, Nicholette D., additional, Peters, Annette, additional, Podgornaia, Anna I., additional, Ponte, Belen, additional, Poulain, Tanja, additional, Pramstaller, Peter P., additional, Rabelink, Ton J., additional, Raffield, Laura M., additional, Reilly, Dermot F., additional, Rettig, Rainer, additional, Rheinberger, Myriam, additional, Rice, Kenneth M., additional, Rivadeneira, Fernando, additional, Runz, Heiko, additional, Ryan, Kathleen A., additional, Sabanayagam, Charumathi, additional, Saum, Kai-Uwe, additional, Schöttker, Ben, additional, Shaffer, Christian M., additional, Shi, Yuan, additional, Smith, Albert V., additional, Strauch, Konstantin, additional, Stumvoll, Michael, additional, Sun, Benjamin B., additional, Szymczak, Silke, additional, Tai, E-Shyong, additional, Tan, Nicholas Y. Q., additional, Taylor, Kent D., additional, Teren, Andrej, additional, Tham, Yih-Chung, additional, Thiery, Joachim, additional, Thio, Chris H. L., additional, Thomsen, Hauke, additional, Thorsteinsdottir, Unnur, additional, Tönjes, Anke, additional, Tremblay, Johanne, additional, Uitterlinden, André G., additional, van der Harst, Pim, additional, Verweij, Niek, additional, Vogelezang, Suzanne, additional, Völker, Uwe, additional, Waldenberger, Melanie, additional, Wang, Chaolong, additional, Wilson, Otis D., additional, Wong, Charlene, additional, Wong, Tien-Yin, additional, Yang, Qiong, additional, Yasuda, Masayuki, additional, Akilesh, Shreeram, additional, Bochud, Murielle, additional, Böger, Carsten A., additional, Devuyst, Olivier, additional, Edwards, Todd L., additional, Ho, Kevin, additional, Morris, Andrew P., additional, Parsa, Afshin, additional, Pendergrass, Sarah A., additional, Psaty, Bruce M., additional, Rotter, Jerome I., additional, Stefansson, Kari, additional, Wilson, James G., additional, Susztak, Katalin, additional, Snieder, Harold, additional, Heid, Iris M., additional, Scholz, Markus, additional, Butterworth, Adam S., additional, Hung, Adriana M., additional, Pattaro, Cristian, additional, and Köttgen, Anna, additional

Published
2019
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300. Singapore Chinese Eye Study: key findings from baseline examination and the rationale, methodology of the 6-year follow-up series

Author

Majithia, Shivani, primary, Tham, Yih Chung, additional, Chee, Miao Li, additional, Teo, Cong Ling, additional, Chee, Miao-Ling, additional, Dai, Wei, additional, Kumari, Neelam, additional, Lamoureux, Ecosse Luc, additional, Sabanayagam, Charumathi, additional, Wong, Tien Yin, additional, and Cheng, Ching-Yu, additional

Published
2019
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