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759 results on '"Tu, Ying"'

251. UPLC-MS-ELSD-PDA as a Powerful Dereplication Tool to Facilitate Compound Identification from Small-Molecule Natural Product Libraries

Author

Yang, Jin, primary, Liang, Qian, additional, Wang, Mei, additional, Jeffries, Cynthia, additional, Smithson, David, additional, Tu, Ying, additional, Boulos, Nidal, additional, Jacob, Melissa R., additional, Shelat, Anang A., additional, Wu, Yunshan, additional, Ravu, Ranga Rao, additional, Gilbertson, Richard, additional, Avery, Mitchell A., additional, Khan, Ikhlas A., additional, Walker, Larry A., additional, Guy, R. Kiplin, additional, and Li, Xing-Cong, additional

Published
2014
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256. Novel concept of atrial tachyarrhythmias originating from the superior vena cava: insight from noncontact mapping

Author

Tu Ying Liu, Pi Chang Lee, Yu An Ding, Satoshi Higa, Shih Ann Chen, Ming Hsiung Hsieh, and Ching Tai Tai

Subjects
Tachycardia, Male, Tachycardia, Ectopic Atrial, medicine.medical_specialty, Vena Cava, Superior, Vena cava, medicine.medical_treatment, Catheter ablation, Imaging, Three-Dimensional, Superior vena cava, Physiology (medical), Internal medicine, Atrial Fibrillation, medicine, Humans, Aged, Atrium (architecture), business.industry, Body Surface Potential Mapping, Atrial fibrillation, Middle Aged, Ablation, medicine.disease, Mapping system, cardiovascular system, Cardiology, Catheter Ablation, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Electrophysiologic Techniques, Cardiac
Abstract

Introduction: Information about the activation patterns inside the superior vena cava (SVC) and entry and exit sites at the SVC-right atrial (RA) junction during SVC tachyarrhythmia is limited. Methods and Results: A detailed characterization of electrophysiologic mechanisms and ablation strategies was performed using a noncontact three-dimensional mapping system in two cases of SVC tachycardia. The first case demonstrated SVC tachycardia originating from an ectopic focus inside the SVC, with sustained depolarization and conduction to the atrium. Entry and exit sites across the SVC-RA junction were located very close to each other. The second case demonstrated two different reentrant circuits, one inside the SVC and the other into and out of the SVC-RA junction. The entry and exit sites were located far away from each other. Conclusion: Noncontact mapping may help to reveal the mechanism of SVC tachyarrhythmias and to locate entry and exit sites at the SVC-RA junction as a guide for catheter ablation.(J Cardiovasc Electrophysiol, Vol. 14, pp. 533-539, May 2003)

Published
2003

258. Treatment of atrial fibrillation by catheter ablation of conduction gaps in the crista terminalis and cavotricuspid isthmus of the right atrium

Author

Shih-Ann Chen, Ching-Tai Tai, and Tu-Ying Liu

Subjects
Male, medicine.medical_specialty, Cavotricuspid isthmus, medicine.medical_treatment, Catheter ablation, Heart Conduction System, Physiology (medical), Internal medicine, Atrial Fibrillation, medicine, Humans, cardiovascular diseases, Heart Atria, Coronary sinus, Aged, business.industry, Body Surface Potential Mapping, Atrial fibrillation, Anatomy, medicine.disease, medicine.anatomical_structure, Mapping system, cardiovascular system, Cardiology, Catheter Ablation, Right atrium, sense organs, Tricuspid Valve, Cardiology and Cardiovascular Medicine, Crista terminalis, business, Electrophysiologic Techniques, Cardiac, Atrial flutter
Abstract

Catheter Ablation of Atrial Fibrillation. A 74-year-old man with atrial fibrillation (AF) underwent electrophysiologic study and catheter ablation with a noncontact mapping system. AF was induced by coronary sinus pacing, and noncontact mapping showed ever-changing movement of multiple wavefronts with one dominant reentrant circuit around the tricuspid annulus, splitting wavefront conduction through the gaps in the crista terminalis, and then fusion and stasis of wavefronts. After creation of bidirectional conduction block over crista terminalis gaps and the cavotricuspid isthmus, AF or atrial flutter was noninducible. No further AF recurrence was noted during 6-month follow-up.

Published
2002

268. Double-Hydrophilic Block Copolymer as an Effective and Environmentally Friendly Inhibitor for Phosphate and Carbonate Scales in Cooling Water Systems

Author

Ling, Lei, primary, Liu, Guangqing, additional, Huang, Jingyi, additional, Wang, Huchuan, additional, Zhou, Yuming, additional, Yao, Qingzhao, additional, Cao, Ke, additional, Liu, Yahui, additional, Tu, Ying, additional, Zhou, Xingkai, additional, Sun, Wei, additional, and Wu, Wendao, additional

Published
2013
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270. DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival

Author

Tu, Ying, primary, Ji, Chao, additional, Yang, Bo, additional, Yang, Zhi, additional, Gu, Hua, additional, Lu, Chun-Cheng, additional, Wang, Rong, additional, Su, Zhong-Lan, additional, Chen, Bin, additional, Sun, Wei-Ling, additional, Xia, Ji-Ping, additional, Bi, Zhi-Gang, additional, and He, Li, additional

Published
2013
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288. Automated High-Throughput System to Fractionate Plant Natural Products for Drug Discovery

Author

Tu, Ying, primary, Jeffries, Cynthia, additional, Ruan, Hong, additional, Nelson, Cynthia, additional, Smithson, David, additional, Shelat, Anang A., additional, Brown, Kristin M., additional, Li, Xing-Cong, additional, Hester, John P., additional, Smillie, Troy, additional, Khan, Ikhlas A., additional, Walker, Larry, additional, Guy, Kip, additional, and Yan, Bing, additional

Published
2010
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293. Filopodial adhesive force in discrete nodes revealed by integrin molecular tension imaging.

Author

Tu, Ying, Pal, Kaushik, Austin, Jacob, and Wang, Xuefeng

Subjects
*MYOSIN, *FILOPODIA, *INTEGRINS, *ACTIVATION energy, *VINCULIN, *ADHESIVES
Abstract

Filopodia are narrow cell extensions involved in various physiological processes. Integrins mediate filopodia adhesion and likely transmit adhesive force to regulate filopodia formation and functions, but the force is extremely weak to study and remains poorly understood. Using integrative tension sensor (ITS), we imaged filopodia adhesive force at the single molecular tension level and investigated the force dynamics and sources. Results show that filopodia integrin tension (FIT) is generated in discrete foci (force nodes) along single filopodia with a spacing of ∼1 μm. Inhibitions of actin polymerization or myosin II activity markedly reduced FIT signals in force nodes at filopodia tips and at filopodia bases, respectively, suggesting differential force sources of FIT in the distal force nodes and proximal ones in filopodia. Using two ITS constructs with different force thresholds for activation, we showed that the molecular force level of FIT is greater at filopodia bases than that at filopodia tips. We also tested the role of vinculin and myosin X in the FIT transmission. With vinculin knockout in cells, filopodia and associated force nodes were still formed normally, suggesting that vinculin is dispensable for the formation of filopodia and force nodes. However, vinculin is indeed required for the transmission of strong FIT (capable of rupturing DNA in a shear conformation), as the strong FIT vanished in filopodia with vinculin knockout. Co-imaging of FIT and myosin X shows no apparent co-localization, demonstrating that myosin X is not directly responsible for generating FIT, despite its prominent role in filopodium elongation. • Filopodia force transmitted by integrins is imaged with single-molecule sensitivity • Filopodia integrin tensions are distributed in force nodes with 1 μm spacing • Vinculin is required for the transmission of high-level filopodia integrin tensions • Myosin X is not responsible for the generation of filopodia integrin tensions Tu et al. image filopodia adhesive force with single-molecule sensitivity. The force is distributed in a dot-like pattern with a spacing of ∼1 μm. Vinculin is dispensable for filopodia formation but required for the transmission of high-level molecular tensions in filopodia. Myosin X is not directly responsible for generating filopodia force. [ABSTRACT FROM AUTHOR]

Published
2022
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298. Enhancing cancer targeting and anticancer activity by a stimulus-sensitive multifunctional polymer-drug conjugate.

Author

Tu, Ying and Zhu, Lin

Subjects
*TARGETED drug delivery, *ANTINEOPLASTIC agents, *BIOCONJUGATES, *STIMULUS & response (Biology), *DRUG resistance, *DRUG side effects
Abstract

Undesirable physicochemical properties, low tumor targeting, insufficient cell internalization, acquired drug resistance, and severe side effects significantly limit the applications of anticancer drugs. In this study, to improve the tumor targeting and drug efficacy of the poorly water-soluble drug, doxorubicin (DOX), a novel drug delivery platform (PEG-ppTAT-DOX) was developed, which contained a polyethylene glycol (PEG), a matrix metalloproteinase 2 (MMP2)-sensitive peptide linker (pp), a cell penetrating peptide (TAT), and a model drug (doxorubicin). The prepared drug platform possessed several key features, including: (i) the nanoparticle formation via the self-assembly; (ii) prevention of the non-specific interaction via the PEGylation; (iii) tumor targeting via the MMP2-mediated PEG deshielding and exposure of the TAT; (iv) the TAT-mediated cell internalization; (v) the TAT-induced endosomal escape; (vi) the inhibition of P-glycoprotein mediated drug efflux; and (vii) the TAT-medicated nuclear translocation. These cooperative functions ensured the improved tumor targetability, enhanced tumor cell internalization, improved intracellular distribution, and potentiated anticancer activity. Compared to the multi-component nanocarriers, the proposed simple but multifunctional polymer-drug conjugate might have greater potential for tumor-targeted drug delivery and enhanced chemotherapy. [ABSTRACT FROM AUTHOR]

Published
2015
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299. Special odd-even effect of degree of oligomerization on properties of cyclic oligoesters.

Author

Wu, Jun, Qu, Tao-guang, Gao, Ling-feng, Yang, Xiao-ming, Li, Xiao-hong, Tu, Ying-feng, and Zhu, Xiu-lin

Subjects
OLIGOMERIZATION, CYCLIC compounds, CYCLOPROPANE, BUTENE, MELTING, REFRACTIVE index
Abstract

We demonstrate here seven pure cyclic samples, which belongs to two series of oligoesters, cyclic oligo(trimethylene terephthalate)s (COTTs) and cyclic oligo(butylene terephthalate)s (COBTs), showing odd-even effect of degree of oligomerization (repeating units number) on properties. The pentamer of COTT and trimer of COBT show much lower melting temperature, and the trimer of COTT and trimer of COBT show significant lower refractive index, which can be ascribed to the low packing density of cyclic oligoesters with odd number of degree of oligomerization. Our results reveal the discrete property change as a function of cyclic size of oligomers, which can be used to design materials with special properties. [ABSTRACT FROM AUTHOR]

Published
2015
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