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1,089 results on '"Xia, Zhengyuan"'

252. cepip: context-dependent epigenomic weighting for prioritization of regulatory variants and disease-associated genes

Author

Li, Mulin Jun, primary, Li, Miaoxin, additional, Liu, Zipeng, additional, Yan, Bin, additional, Pan, Zhicheng, additional, Huang, Dandan, additional, Liang, Qian, additional, Ying, Dingge, additional, Xu, Feng, additional, Yao, Hongcheng, additional, Wang, Panwen, additional, Kocher, Jean-Pierre A., additional, Xia, Zhengyuan, additional, Sham, Pak Chung, additional, Liu, Jun S., additional, and Wang, Junwen, additional

Published
2017
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260. Vascular endothelial growth factor regulation of endothelial nitric oxide synthase phosphorylation is involved in isoflurane cardiac preconditioning.

Author

Liu, Yanan, Paterson, Mark, Baumgardt, Shelley L, Irwin, Michael G, Xia, Zhengyuan, Bosnjak, Zeljko J, and Ge, Zhi-Dong

Abstract

Aims Previous studies indicate that nitric oxide derived from endothelial nitric oxide synthase (eNOS) serves as both trigger and mediator in anaesthetic cardiac preconditioning. The mechanisms underlying regulation of eNOS by volatile anaesthetics have not been fully understood. Therefore, this study examined the role of vascular endothelial growth factor (VEGF) in isoflurane cardiac preconditioning. Methods and results Wistar rats underwent 30 min of coronary artery occlusion followed by 2 h of reperfusion. Isoflurane given prior to ischaemia/reperfusion significantly decreased myocardial infarct size from 60 ± 1% in control to 40 ± 3% (n  = 8 rats/group, P  < 0.05). The beneficial effects of isoflurane were blocked by neutralizing antibody against VEGF (nVEGF). Coronary arterial endothelial cells (ECs) alone or together with cardiomyocytes (CMs) were subjected to hypoxia/reoxygenation injury. The expression of VEGF and eNOS was analysed by western blot, and nitric oxide was measured by ozone-based chemiluminescence. In co-cultured CMs and ECs, isoflurane administered before hypoxia/reoxygenation attenuated lactate dehydrogenase activity and increased the ratio of phosphorylated eNOS/eNOS and nitric oxide production. The protective effect of isoflurane on CMs was compromised by nVEGF and after VEGF in ECs was inhibited with hypoxia inducible factor-1α short hairpin RNA (shRNA). The negative effect of hypoxia inducible factor-1α shRNA was restored by recombinant VEGF. Conclusion Isoflurane cardiac preconditioning is associated with VEGF regulation of phosphorylation of eNOS and nitric oxide production. [ABSTRACT FROM AUTHOR]

Published
2019
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261. Predictors of Short-term Outcomes Following Repair of Anomalous Origin of the Left Coronary Artery From the Pulmonary Artery in Chinese Children: A Case-Control Study.

Author

Zhang, Chaobin, Luo, Qipeng, Li, Yinan, Wu, Xie, Hao, Zhang, Li, Shoujun, Xia, Zhengyuan, Yan, Fuxia, and Sun, Li

Abstract

Objective To analyze the predictive factors associated with prolonged mechanical ventilation (PMV) and prolonged duration of inotropic support (PDIS) following anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) surgery with possible concomitant mitral valve procedure (MVP) in a relatively young population. Design A retrospective case-control study. Setting Fuwai hospital. Participants Pediatric patients with ALCAPA surgery from July 2010 to October 2017. Interventions None. Measurements and Main Results PMV was defined as a mechanical ventilation time ≥48 hours and PDIS as a duration of inotropic support ≥6 days. Univariate analysis, logistic regression analysis, and receiver operating characteristic curve analysis were used to identify independent predictors of PMV and PDIS. The independent predictors of PMV were found to be the left ventricular end-diastolic diameter z-score (LVEDDz), estimate of glomerular filtration rate (eGFR) and maximum vasoactive-inotropic score (VISm). The odds ratios and 95% confidence intervals for these predictors of PMV were the following: LVEDDz, 1.58 (1.19-2.09); eGFR, 0.96 (0.93-0.998); and VISm, 1.08 (1.01-1.17). The predictor of PDIS was LVEDDz at 1.65 (1.26-2.15). One patient died during hospitalization, and there was no reoperation. Thirty-seven patients received concomitant MVP with no hospital mortality. At discharge, mitral regurgitation (MR) had improved in all patients with MR. Patients with PMV were associated with more acute kidney injury, PDIS, and longer ICU and hospital stays. Conclusions In relatively young individuals who received ALCAPA surgery and possible concomitant MVP, short-term outcomes are favorable. Based on their experience bias, the authors recommend combining LVEDDz, eGFR, and VISm to predict PMV and applying LVEDDz for PDIS. [ABSTRACT FROM AUTHOR]

Published
2018
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263. Propofol inhibits myocardial injury induced by microvesicles derived from hypoxia-reoxygenated endothelial cells via lncCCT4-2/CCT4 signaling

Author

Zhang, Xiaojun, Wang, Changsen, Xu, Hao, Cai, Shuyun, Liu, Keyu, Li, Simeng, Chen, Linming, Shen, Siman, Gu, Xiaoxia, Tang, Jing, Xia, Zhengyuan, Hu, Zhe, Ma, Xiaotang, and Zhang, Liangqing

Abstract

Microvesicles from hypoxic/reoxygenated HUVECs (HR-EMVs) exacerbated oxidative stress and apoptosis in IR-injured cardiomyocytes.

Published
2023
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270. Predicting regulatory variants with composite statistic

Author

Li, Mulin Jun, primary, Pan, Zhicheng, additional, Liu, Zipeng, additional, Wu, Jiexing, additional, Wang, Panwen, additional, Zhu, Yun, additional, Xu, Feng, additional, Xia, Zhengyuan, additional, Sham, Pak Chung, additional, Kocher, Jean-Pierre A., additional, Li, Miaoxin, additional, Liu, Jun S., additional, and Wang, Junwen, additional

Published
2016
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280. Remifentanil Preconditioning Reduces Postischemic Myocardial Infarction and Improves Left Ventricular Performance via Activation of the Janus Activated Kinase-2/Signal Transducers and Activators of Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen Synthase Kinase-3β in Rats

Author

Qiao, Shigang, primary, Mao, Xiaowen, additional, Wang, Yan, additional, Lei, Shaoqing, additional, Liu, Yanan, additional, Wang, Tingting, additional, Wong, Gordon T., additional, Cheung, Chi-Wai, additional, Xia, Zhengyuan, additional, and Irwin, Michael G., additional

Published
2016
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283. Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K/Akt and JAK2/STAT3 pathways

Author

Xue, Rui, primary, Lei, Shaoqing, additional, Xia, Zhong-yuan, additional, Wu, Yang, additional, Meng, Qingtao, additional, Zhan, Liying, additional, Su, Wating, additional, Liu, Huimin, additional, Xu, Jinjin, additional, Liu, Zhenzhen, additional, Zhou, Bin, additional, and Xia, Zhengyuan, additional

Published
2016
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292. Cardiac protective effects of remote ischaemic preconditioning in children undergoing tetralogy of fallot repair surgery: a randomized controlled trial.

Author

Wu, Qingping, Wang, Tingting, Chen, Shiqiang, Zhou, Quanjun, Li, Haobo, Hu, Na, Feng, Yinglu, Dong, Nianguo, Yao, Shanglong, and Xia, Zhengyuan

Abstract

Aims Remote ischaemic preconditioning (RIPC) by inducing brief ischaemia in distant tissues protects the heart against myocardial ischaemia-reperfusion injury (IRI) in children undergoing open-heart surgery, although its effectiveness in adults with comorbidities is controversial. The effectiveness and mechanism of RIPC with respect to myocardial IRI in children with tetralogy of Fallot (ToF), a severe cyanotic congenital cardiac disease, undergoing open heart surgery are unclear. We hypothesized that RIPC can confer cardioprotection in children undergoing ToF repair surgery. Methods and results Overall, 112 ToF children undergoing radical open cardiac surgery using cardiopulmonary bypass (CPB) were randomized to either a RIPC group (n = 55) or a control group (n = 57). The RIPC protocol consisted of three cycles of 5-min lower limb occlusion and 5-min reperfusion using a cuff-inflator. Serum inflammatory cytokines and cardiac injury markers were measured before surgery and after CPB. Right ventricle outflow tract (RVOT) tissues were collected during the surgery to assess hypoxia-inducible factor (Hif)-1α and other signalling proteins. Cardiac mitochondrial injury was assessed by electron microscopy. The primary results showed that the length of stay in the intensive care unit (ICU) was longer in the control group than in the RIPC group (52.30 ± 13.43 h vs. 47.55 ± 10.34 h, respectively, P = 0.039). Patients in the control group needed longer post-operative ventilation time compared to the RIPC group (35.02 ± 6.56 h vs. 31.96 ± 6.60 h, respectively, P = 0.016). The levels of post-operative serum troponin-T at 12 and 18 h, CK-MB at 24 h, as well as the serum h-FABP levels at 6 h, after CPB were significantly lower, which was coincident with significantly higher protein expression of cardiac Hif-1α, p-Akt, p-STAT3, p-STAT5, and p-eNOS and less vacuolization of mitochondria in the RIPC group compared to the control group. Conclusion In ToF children undergoing open heart surgery, RIPC attenuates myocardial IRI and improves the short-term prognosis. [ABSTRACT FROM AUTHOR]

Published
2018
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300. Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction

Author

Zhou, Mi, primary, Bao, Yuqian, additional, Li, Haobo, additional, Pan, Yong, additional, Shu, Lingling, additional, Xia, Zhengyuan, additional, Wu, Donghai, additional, Lam, Karen S.L., additional, Vanhoutte, Paul M., additional, Xu, Aimin, additional, Jia, Weiping, additional, and Hoo, Ruby L.-C., additional

Published
2015
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