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Your search keyword '"Yoshiki, Sugimura"' showing total 254 results
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254 results on '"Yoshiki, Sugimura"'

251. [Study of intraglandular heterogeneity of hormonal dependency in rat prostate]

Author

Norio Hayashi, Sakurai M, Juichi Kawamura, and Yoshiki Sugimura

Subjects
Oncology, Male, medicine.medical_specialty, Dependency (UML), Estradiol, business.industry, Urology, Prostate, Rats, Inbred Strains, Rats, Rat Prostate, Internal medicine, Androgens, Medicine, Animals, Regeneration, Castration, business, Hormone
Published
1988

252. [The clinicopathological study of bladder tumor. 1. The study and attempt to clarify the growing mode of tumor quantitatively evaluated by mapping histology]

Author

Juichi Kawamura, Tajima K, Hiromi Tochigi, Yoshiki Sugimura, Kinoshita N, Taizo Shiraishi, and Natsuki Hori

Subjects
Male, Pathology, medicine.medical_specialty, Urology, Urinary Bladder, Adenocarcinoma, Text mining, medicine, Bladder tumor, Humans, Neoplasm Invasiveness, Aged, Carcinoma, Transitional Cell, Urinary bladder, CARCINOMA TRANSITIONAL CELL, business.industry, Histology, Middle Aged, medicine.disease, medicine.anatomical_structure, Cell Transformation, Neoplastic, Urinary Bladder Neoplasms, Carcinoma, Squamous Cell, Female, business
Published
1987

253. Impact of pre-treatment prostate tissue androgen content on the prediction of castration-resistant prostate cancer development in patients treated with primary androgen deprivation therapy

Author

Norio Nonomura, Naoya Masumori, Susumu Umemoto, Hideki Sakai, Seiji Arai, N. Kamiya, Seijiro Honma, Yasuhide Miyoshi, Yasuhide Kitagawa, Kazuhiro Suzuki, Tomohiko Ichikawa, Yoshinobu Kubota, Yasuhiro Shibata, Yoshiki Sugimura, and Atsushi Mizokami

Subjects
Male, PCA3, medicine.medical_specialty, Prostate biopsy, medicine.drug_class, Urology, Endocrinology, Diabetes and Metabolism, urologic and male genital diseases, Androgen deprivation therapy, Prostate cancer, Endocrinology, Prostate, Internal medicine, medicine, Humans, Orchiectomy, Aged, medicine.diagnostic_test, business.industry, Prostatic Neoplasms, Androgen Antagonists, Androgen, medicine.disease, Prostate-specific antigen, medicine.anatomical_structure, Reproductive Medicine, Androgens, business
Abstract

Summary Great advances in tissue androgen analysis using liquid chromatography-tandem mass spectrometry (LC-MS/MS) have made it possible to evaluate the tissue androgen content from a single needle prostate biopsy specimen. In this study, we investigated if pre-treatment androgen content in prostate biopsy specimens could predict their response to primary androgen deprivation therapy (ADT) and future castration-resistant prostate cancer (CRPC). One-hundred and sixty-five prostate cancer patients who received primary ADT were enrolled. They had received multiple core prostate needle biopsy at diagnosis, and an additional one needle biopsy specimen was obtained for tissue androgen determination using LC-MS/MS. The patients' prostate specific antigen (PSA) values were periodically followed during the treatment and patients were determined to have CRPC when their PSA value increased continuously to 25% above the nadir and a 2.0 ng/mL increase. A significant correlation was found between PSA value decline velocity (PSA half-time) after ADT and pre-ADT tissue androgen content. Twenty-three patients were determined to have CRPC. These CRPC patients had a significantly high concentration of tissue T (p

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