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Copyright of National Palace Museum Research Quarterly is the property of National Palace Museum and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Protein kinase C (PKC) is a group of phospholipid-dependent serine/threonine protein kinases, which together with protein kinase A (PKA) and protein kinase G (PKG) constitute a superfamily of serine/threonine protein kinase AGC. PKC includes classic PKC, novel PKC, atypical PKC and some members of kinase associated with PKC (PRK). PKC is widely distributed in mammalian tissues and cells, which plays an important biological role in growth and metabolism, proliferation and differentiation of cells. A series of studies have demonstrated that variations of multiple cells, occurrence and development of diseases are related to the abnormal expression of PKC. Therefore, designing and searching for efficient PKC inhibitors have very important implications for synthesis of many kinds of effective drugs and treatment of a variety of clinical diseases including cancer, cardiovascular, and hypertension, et al. In recent years, the research on PKC inhibitors has become the focus of domestic and foreign research. A large number of literatures have reported many kinds of effective PKC inhibitors, and analyzed their function site, mechanism, clinical trial data and so on. The discovery of these PKC inhibitors has important implications for structural analysis of PKC and the treatment of diseases. So in this paper, the efficient PKC inhibitors are summarized. [ABSTRACT FROM AUTHOR]

目的探讨延续护理对提高携T 管出院患者管道护理能力和医疗服务满意度的效果。方法采用历 史对照类实验研究方法，选择110 例因肝胆管结石在该科行胆道引流并携管出院的患者作为研究对象。以2015 年5 月 至2016 年5 月携管出院患者作为对照组，以2016 年6 月至2017 年5 月携管出院患者作为干预组，每组55 例。对照组 实施常规健康指导，干预组在常规健康指导的基础上实施个体化延续性护理，比较2 组患者T 管护理能力和医疗服务 满意度。结果干预组T 管护理知识问卷调查得分及出院护理满意度均高于对照组，差异有统计学意义（P<0.05）。结 论个体化延续护理干预提高了患者对疾病的认知及对管道的自我维护意识，同时提高了患者出院护理满意度。 [ABSTRACT FROM AUTHOR]

禁食是经内镜治疗的消化道肿瘤患者术后常规的护理措施，然而患者在禁食期间常发生主观饥饿感或 低血糖事件，不仅让患者因不适感增加而导致治疗配合度降低，而且还增加了医疗风险、延长住院时间，最终致使患者 住院费用显著增加。针对患者内镜下治疗期间低血糖进行防范管理，有助于减少低血糖的发生，提高患者依从性，控制 住院时间，降低住院费用，保证医疗安全。 [ABSTRACT FROM AUTHOR]

Monoclonal antibodies (mAbs) have a high specificity and have been widely used in various diseases, especially in the treatment and study of liver injury induced by viruses. In recent years, human mAbs directly prepared from single B lymphocytes have been getting more and ore attention due to high antigenic specificity, low immunogenicity, and good safety and efficiency. With the continuous improvement in monoclonal antibody technology and polymerase chain reaction technology, the antibody preparation technology based on single B lymphocytes has been developed greatly. Although there are rare reports about the mAbs which are derived from single B lymphocytes and applied in liver diseases, the application of such mAbs is promising in the treatment and study of liver diseases. This article reviews the research advances in the development of antibody preparation technology based on single B lymphocytes and the application of the prepared antibodies in liver diseases. [ABSTRACT FROM AUTHOR]

Copyright of Diagnostic Imaging & Interventional Radiology is the property of Editorial Office of Diagnostic Imaging & Interventional Radiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Jianzhu Cailiao Xuebao: Journal of Building Materials is the property of Journal of Building Materials and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的探讨集束化管理在提高急诊护理文书书写质量的效果。方法选取2014年1—12月该院急诊科留观大病历110份并从中选取抢救护理记录单50份作为对照组,选取2015年1—12月留观大病历110份,并从中选取抢救护理记录单50份作为研究组并进行集束化管理,分析比较急诊科责任护士及高级责任护士留观大病历及抢救护理记录单书写情况。结果 2015年留观大病历各项文书书写情况均明显优于2014年,差异均有统计学意义(P<0.05);2015年抢救护理记录单各项书写情况均明显优于2014年,差异均有统计学意义(P<0.05)。结论采用集束化管理模式能有效提高急诊护理文书书写质量及书写规范性,能培养护理人员应有的慎独精神,树立严谨的工作作风,进一步增强护理人员的责任感,在临床应用中具有推广价值。 [ABSTRACT FROM AUTHOR]

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的探讨品管圈（QCC)活动在降低糖尿病患者低血糖发生率中的应用。方法选取本科2015年 5~10月收治入院的2塑糖尿病患者为研究对象。按QCC理论步骤进行计划、实施、确认和处置（PDCA)，分析导致糖尿病 患者发生低血糖的原因，针对性地拟定对策并实施，经PDCA循环后进行效果评价。结果实施$CC后，糖尿病患者低 血糖发生率由改善前的28.72%下降至改善后的12.62%，差异有统计学意义(P<0.05)。圈员解决问题的能力、个人素质修 养、沟通协调能力、责任心、自信心、团队精神、工作积极性和QCC手法均较之前有所提高，尤其是自信心与QCC手法的 应用。结论运用QCC可有效降低糖尿病患者的低血糖发生率，保证患者护理安全和治疗效果，提高QCC圈员的品管 手法、创新意识及解决问题的能力。 [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of early enteral nutrition support combined with minimally invasive percutaneous drainage of abdominal cavity on the immune function and nutritional status in the patients with severe acute pancreatitis (SAP). Methods 40 cases of SAP in our hospital from August 2012 to February 2015 were selected as the research subjects and randomly divided into the observation group and the control group according to the odd and even number of admission, 20 cases in each group. The observation group was given early enteral nutrition support combined with minimally invasive percutaneous drainage of abdominal cavity based on the traditional comprehensive treatment, while the control group was given the traditional comprehensive treatment. The immune function (CD4/CD8 ratio, IgG level) before and after treatment, serum albumin and prealbumin change, WBC, blood amylase level on 1, 7, 14, 21 d after admission, mortality after treatment, hospitalization time and treatment cost were also observed. Results The serum CD4/CD8 ratio and IgG level after treatment in the observation group were significantly improved compared with the before treatment and the control group after treatment,the difference was statistically significant (P<0.05); WBC and blood amylase levels on 7,14, 21 d of treatment in the observation group were decreased compared with the control group, the serum prealbumin level was significantly higher than before treatment, moreover significantly increased compared with the control group after treatment, the difference was statistically significant (P<0.05); the mortality in the observation group was 5.0% (1/20), which was significantly lower than 25.0% (5/20) in the control group, the hospitalization time and treatment costs were significantly less than those in the control group, the difference was statistically significant (P<0.05). Conclusion Early enteral nutrition support combined with intraperitoneal drainage in the treatment of SAP can significantly improve the nutritional status and immune function with low treatment costs, short treatment time, low mortality and definite effect. [ABSTRACT FROM AUTHOR]

BACKGROUND: The advantage of oblique lumbar interbody fusion for lumbar degenerative diseases is affected by the cage settlement. Supplementary fixation can provide extra biomechanical stability and may reduce the occurrence of settlement. Among them, oblique lumbar interbody fusion combined with lateral plate fixation can avoid the damage caused by the posterior approach. OBJECTIVE: To analyze the early clinical and radiological results of oblique lumbar interbody fusion combined with lateral plate in the treatment of lumbar degenerative diseases, and to combine with bilateral pedicle screws to analyze whether there is a difference in the degree of cage settlement. METHODS: Fourteen patients (17 segments) with oblique lumbar interbody fusion combined with lateral plate fixation (lateral plate group) and 12 patients (15 segments) with oblique lumbar interbody fusion combined with bilateral pedicle screw fixation (bilateral pedicle screw group) were included. The clinical and radiological data of patients before operation, 3 days and 6 months after operation were recorded. The clinical evaluation included low back pain and lower limb pain visual analogue scale scores and Oswestry disability index score. Radiological evaluation included measurement of disc height, segmental lordosis, and degree of cage settlement. RESULTS AND CONCLUSION: (1) There was no significant difference between the two groups in age, gender, body mass index, quantitative CT bone mineral density, and preoperative diagnosis. The operation time of the bilateral pedicle screw group was significantly higher than that of the lateral plate group (P=0.025). The complication rate was 43% in lateral plate group and 33% in bilateral pedicle screw group. There was no significant difference between the two groups in operation segment, blood loss, and complication rate. (2) There was no significant difference in low back pain and lower limb pain visual analogue scale scores and preoperative Oswestry disability index scores between the two groups. The Oswestry disability index score of the bilateral pedicle screw group was significantly lower than that of the lateral plate group at 6 months after operation (P=0.007). At 6 months after operation, the visual analogue scale scores and Oswestry disability index scores were significantly improved in both groups compared with those before the operation (P < 0.05). (3) At 3 days after operation, disc height and segmental lordosis were significantly improved compared with before operation, but there was a significant loss of disc height in both groups at 6 months after operation (P < 0.05). There was no significant difference in disc height between the two groups before and 3 days after the operation. The disc height of the lateral plate group was significantly lower than that of the bilateral pedicle screw group at 6 months follow-up (P=0.044). (4) No statistical difference was found in segmental lordosis between the two groups. (5) There was no significant difference in the cage settlement rate between the two groups at 6 months follow-up. There were two cases of severe subsidence in the lateral plate group and none in the bilateral pedicle screw group. (6) Compared with oblique lumbar interbody fusion combined with bilateral pedicle screws, oblique lumbar interbody fusion combined with lateral plate fixation in the treatment of lumbar degenerative diseases is less effective in preventing early cage settlement. Both have similar pain relief effects at the early stage, but in terms of quality of life, oblique lumbar interbody fusion combined with bilateral pedicle screw fixation is better than oblique lumbar interbody fusion combined with lateral plate fixation. [ABSTRACT FROM AUTHOR]

Objective: To explore core and bridge nodes in a network of alexithymia and cognitive emotion regulation strategies in older adults with chronic co-morbidities in the communities. Methods: Totally 436 older adults with chronic co-morbidities in the communities were selected and surveyed with the Toronto alexithymia Scale(TAS) and Cognitive Emotion Regulation Questionnaire(CERQ). Network estimation, centrality and predictability measurements, accuracy and stability validation, and network comparisons based on the R language were performed to identify core and bridge nodes in the network and to compare differences in network structure across gender and residence. Results: Catastrophizing was the highest strength node in the network(strength=1. 28) and was identified as a core node. The difficulty identifying feelings had the highest bridge strength(bridge strength=0. 52), followed by the externally oriented thoughts(bridge strength=0. 48), and blaming oneself(bridge strength=0. 41)were identified as bridge nodes. The results of the network comparison test showed that the differences in the structure of the network of alexithymia and cognitive emotion regulation strategies among older adults with chronic comorbidities across gender and place of residence were not statistically significant(P＞ 0. 05), but the nodes within the network were tightly connected. Conclusion:Older adults with chronic co-morbidities use catastrophizing as a primary cognitive-emotional regulation strategy. Difficulty identifying feelings, externally oriented thoughts and selfblame as the main ways in which their alexithymia are connected to cognitive-emotional regulation strategies [ABSTRACT FROM AUTHOR]

As a reversible posttranslational modification, phosphorylation can modulate the protein's activity through altering its conformation. Histidine phosphorylation plays a key role in signal transduction and is frequently involved in various human diseases. Due to the lability of the phosphoramidate (P-N) bond of phosphohistidine, histidine phosphorylation is still difficult to detect and has only been reported by a relative handful of studies, which is much less than other phosphorylation modification. In this article, we review the advance of studies on the histidine phosphorylation in recent years and summary its biological functions, which can provide theoretical support for further research. [ABSTRACT FROM AUTHOR]

目的 探讨改良LOVE术对伴腰骶椎侧弯的腰椎间盘突出症患者主观症状和侧弯情况的影响。方法 选择伴腰骶椎侧弯的腰椎间盘突出症患者56例，均行改良LOVE术。记录患者术前及术后3个月的Cobb角、视觉模拟评分（VAS）和日本矫形外科协会（JOA）评分，计算相应改善值，并分析其相关性。结果 患者术前及术后3个月Cobb角分别为7．1°（5．7°，12．3°）、3．0°（1．9°，4．6°），VAS分别为7．0（6．0，7．8）、0．5（0，1．0）分，JOA评分分别为（13．8±4．6）、（27．0±1．7）分，P均＜0．01。 Cobb角改善值为4．0°（2．9°，9．1°），VAS改善值为6．0（5．0，7．0）分，JOA改善值为（13．2±4．3）分。 Cobb角改善值与VAS、JOA改善值均无关（r分别为0．089、0．029），术前Cobb角和JOA改善值无关（r＝0．001），P均＞0．05。结论改良 LOVE 术可改善伴腰骶椎侧弯的腰椎间盘突出症患者的主观症状和腰骶椎侧弯，但主观症状的改善和腰骶椎侧弯的减轻无关。 [ABSTRACT FROM AUTHOR]

Objective To investigate the value of thrombomodulin (TM), thrombin-antithrombin complex (TAT), α2 plasmin inhibitor-plasmin complex (PIC) and tissue plasminogen activator-inhibitor complex (t-PAIC) in the diagnosis and prognosis of neonatal disseminated intravascular coagulation (DIC). Methods Eighty-seven DIC neonates (the observation group) were included and divided into the survival group (66 cases) and the death group (21 cases) based on their outcomes at discharge. And 50 healthy newborns born in the same period were selected as the control group. The clinical data of neonates were collected, and risk factors of neonatal DIC were analyzed by Logistic regression. The differences of TM, TAT, PIC and t-PAIC levels in different groups were analyzed. The receiver operating characteristic (ROC) curve was used to analyze values of TM, TAT, PIC and t-PAIC in the diagnosis and prognosis of neonatal DIC. Results The incidence of low Apgar score, birth asphyxia, IVH, sepsis and maternal pregnancy induced hypertension syndrome (PIH) were higher in the observation group than those in the control group (P＜0.05). Multivariate Logistic regression analysis showed that low Apgar score, birth asphyxia, sepsis and PIH were independent risk factors for neonatal DIC. TM, TAT, PIC and t-PAIC levels were higher in the observation group than those in the control group (P＜0.05). ROC curve showed that the combined diagnosis value of TM, TAT, PIC and t-PAIC was better than that of single diagnosis of neonatal DIC. TM and TAT levels were higher in the death group than those in the survival group (P＜0.05), and there were no significant differences in PIC and t-PAIC levels between the two groups. Multivariate Logistic regression analysis showed that elevated TAT level was an independent risk factor for neonatal DIC prognosis. ROC curve showed that when TAT was 21.72 µg/L, the area under the curve for predicting neonatal DIC prognosis was 0.772 (95%CI: 0.666-0.878), and the sensitivity and specificity were 76.2% and 71.2%, respectively. Conclusion The combined application of TM, TAT, PIC and t-PAIC has important clinical value in diagnosis and prognosis evaluation of neonatal DIC. [ABSTRACT FROM AUTHOR]

The power transmission and distribution price is the key to the electricity market reform, and an important foundation for promoting the liberalization of the electricity sales market. With the deepening of the reform of transmission and distribution tariffs, differential pricing methods are in need. The paper takes the large industry users as the research object. Firstly, the loading intervals of the users are divided by introducing the Hansen threshold model. Secondly, based on the long-term incremental cost allocation model for the transmission and distribution networks, the differential loading rate based transmission and distribution tariff pricing method is proposed. By introducing the time-of-use price (TOU price), a TOU transmission and distribution price optimization model considering the different loading rates is established, to design the TOU transmission and distribution prices by the voltage grade and loading rate. Finally, the large industry users in H Province of central China are taken as the example to verify the feasibility of the model presented. The results show that the TOU transmission and distribution tariff pricing model possesses the efficiency of both load-rate price and TOU price, which could effectively regulate the demand of power users, achieve the load shifting and ease the transmission and distribution network congestion problems to some extent. [ABSTRACT FROM AUTHOR]

Objective To observe the changes in glycolipid metabolism and the morphology of multiple tissues and organs in mice with circadian rhythm disorder induced by constant light exposure, and to explore their internal relationship. Methods　Sixty healthy male C57BL/6J mice without specific pathogen grade were divided into 12-h light-12-h dark cycle group (LD) and 24-h constant light group (LL) according to random number table. Intraperitoneal glucose tolerance test was performed to detect the fasting plasma glucose (FPG) of mice and measure the body weight of mice. The levels of free fatty acids (FFA), triglycerides (TG), cholesterol (TC), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), fasting insulin (FINS) and urine 6-sulfatoxymelatonin (6-SML) were determined by enzyme linked immunosorbent assay (ELISA). The glucose area under the curve (AUCG) and homeostasis model assessment for insulin resistance index (HOMA-IR) were calculated. Body fat distribution was evaluated by magnetic resonance imaging. The mRNA of core circadian clock gene nuclear receptor subfamily 1, group D, member 1 (Rev-erbα) in skeletal muscle and liver were observed by real-time fluorescence quantitative PCR; the pathological microstructures of fat, skeletal muscle, myocardium and kidney in mice were observed by optical microscopy and transmission electron microscopy. Two-way analysis of variance (ANOVA) was used to compare the difference of circadian rhythm between the two groups, and the independent sample t-test was used to compare the other data between the two groups. Results　 Compared with the LD group, the level of 6-SML in nocturnal urine of LL group was decreased (P<0.05); the expression rhythm of Rev-erbα mRNA in skeletal muscle and liver was changed; and the body weight, the level of serum FFA, TG, TC, IL-6, TNF-α, FPG, FINS, visceral fat volume, AUCG and HOMA-IR were significantly increased in LL group(P<0.05). Further observation by optical microscope and transmission electron microscope showed that continuous light could cause different degrees of pathological damage to fat, skeletal muscle, myocardium and kidney in LL group. Further light microscopy and transmission electron microscopy showed that constant light could cause pathological damage to fat, skeletal muscle, myocardium and kidney. Conclusion　It is intuitively explained that continuous light leads to disorder of glucose and lipid metabolism and morphological changes of multiple organs in mice, suggesting that circadian rhythm disorder can adversely affect the body in many aspects. [ABSTRACT FROM AUTHOR]

Objective To investigate the value of Baveno Ⅶ criteria versus Expanded Baveno Ⅶ criteria in screening for high-risk varices (HRV) in patients with compensated advanced chronic liver disease (cACLD). Methods A total of 146 patients with cACLD who were admitted to Beijing Shijitan Hospital, Capital Medical University, from January 2016 to December 2018 were enrolled, and according to the absence or presence of HRV based on gastroscopy, they were divided into HRV group with 68 patients and control group with 78 patients. Clinical data, liver stiffness measurement (LSM), and gastroscopy findings were analyzed, and different Baveno Ⅶ criteria were analyzed in terms of their sensitivity and specificity in the diagnosis of HRV. The Mann-Whitney U test and the McNemar test were used for comparison of continuous data between groups, and the chi-square test was used for comparison of categorical data between groups. A univariate logistic regression analysis was performed for the variables used to predict HRV, and a multivariate analysis was performed for the variables with P < 0.1. The two sets of Baveno Ⅶ criteria were compared in terms of their sensitivity and specificity in the diagnosis of HRV. Results A total of 146 patients were enrolled in the study, among whom 68 (46.6%) were found to have HRV. The median age was 54 years (range 29-84 years), male patients accounted for 65.8%, and hepatitis B virus was the main etiology observed in 115 patients (78.8%). The univariate logistic regression analysis showed that LSM and platelet count (PLT) were associated with HRV (both P < 0.05). The multivariate analysis showed that based on Baveno Ⅶ criteria, LSM > 20 kPa or PLT < 150×109/L was associated with HRV (both P < 0.05), and based on Expanded Baveno Ⅶ criteria, LSM > 25 kPa or PLT < 110×109/L was associated with HRV (both P < 0.05). LSM and PLT had an area under the ROC curve of 0.797 (95% confidence interval [CI]: 0.723-0.859) and 0.789 (95% CI: 0.714-0.852), respectively, in the diagnosis of HRV. There were significant differences in the prevalence rates of esophageal and gastric varices and HRV between the patients who met Baveno Ⅶ criteria and those who did not meet such criteria (χ²=23.14 and 23.14, both P < 0.001), as well as between the patients who met Expanded Baveno Ⅶ criteria and those who did not meet such criteria (χ²=43.51 and 25.71, both P < 0.001). Although a higher proportion of patients were exempted from gastroscopy based on Expanded Baveno Ⅶ criteria (32.9% vs 13.7%), Baveno Ⅶ criteria had higher sensitivity (0.98 vs 0.88) and negative predictive value (0.95 vs 0.83) and could better avoid the missed diagnosis of HRV (1.0% vs 9.3%). Conclusion Baveno Ⅶ criteria are more suitable for the screening for HRV in cACLD patients in China. [ABSTRACT FROM AUTHOR]

The monocline slope of Yongshan county is an ancient landslide accumulation body, located in the south of Jinsha River. Since 1979, the H1 and H2 landslides in the eastern part of the ancient landslide have revived and deformed respectively, seriously threatening the safety of more than 35,000 people"s lives and property in Yongshan County on the upper part of the revived landslide. In this study, surface investigation, surface and underground displacement monitoring and numerical simulation methods were used to analyze the characteristics of revived landslide deformation and stability of revived landslide under different working conditions in the east of Yongshan county. The results show that the deformation of the resurrected H1 landslide is obvious at the present stage, and the deformation of the north and east side is the most severe, with an average horizontal displacement rate of 0.63mm/d. H1 is in the accelerated deformation stage as a whole. H2 landslide is in the stage of creep deformation, and small tensile cracks are locally developed at the back edge. There are three sliding surfaces in reviving landslide: The first shear outlet of H1 landslide, the second shear outlet of H1 landslide, and the H2 landslide were analyzed and evaluated by M-P method and Spencer method in limit equilibrium method under different working conditions. It was concluded that the stability characteristics of numerical simulation were basically consistent with the deformation characteristics of monitoring. Heavy rain had the greatest influence on the landslide resurrection deformation, followed by earthquake. Therefore, the problems of sub-regional governance and interception and drainage need to be fully considered in the later treatment. [ABSTRACT FROM AUTHOR]

【Objective】The present paper aimed to prepare a monoclonal antibody against O,O-diethyl organophosphorus pesticides (DPPs) and establish an indirect competitive enzyme-linked immunosorbent assay (ic-ELISA), so as to provide technological support for rapid detection of organophosphorus pesticide residues.【Method】Compound (E)-3-[4- (diethoxyphosphorothioyloxy) phenyl] acrylic acid was used as hapten to make antigen. Immunized mice were screened to prepare monoclonal cell lines that stably secreted antibodies that recognized DPPs. The positive rate and recognition rate of the fusion cell lines were evaluated and the monoclonal cell lines stably secreting antibodies against DPPs were screened. Then, the best concentration combination of antigen and antibody was selected, and the standard curve of ic-ELISA was established. Based on the cross-reactivity rate of the antibody with 6 DPPs, the broad-spectrum of ic-ELISA was evaluated. The cross reaction between the antibody and quinalphos was the strongest, thus the addition and recovery test of quinalphos was carried out on citrus and fresh orange samples.【Result】Artificial antigens were synthesized successfully, including coating antigen DPPs-OVA and immune antigen DPPs-BSA. Sensitive and broad-spectrum cell line 5G8 was obtained by limited dilution method. 0.5 μg/mL coating antigen DPPs-OVA and 1.0 μg/mL antibody 5G82D5 made up the best working concentration combination. Parathion, a pesticide with high antibody recognition rate in this cell line screening, was selected as the inhibition standard, and its ic-ELISA and standard curve were established. The half inhibitory concentration (IC50) was 41.78 ng/mL, and the detection range(IC20-IC80) was 3.21-239.59 ng/mL. The established ic-ELISA showed varying degrees of cross reactions with 5 DPPs (coumaphos, quinalphos, phorate, methyl parathion and fenthion). The cross-reactivity rate of quinalphos was the highest, which was 19.79%. The recoveries of quinalphos in citrus and orange samples by ic-ELISA and GC were compared. The recoveries of ic-ELISA ranged from 75.80% to 116.12%,while the recoveries of GC ranged from 92.5% to 115.00%. The results of the two methods are in good agreement.【Conclusion】The established ic-ELISA has high cross-validation accuracy by GC method and can rapidly detect quetiapine residues in agricultural products. [ABSTRACT FROM AUTHOR]

］目的•建立预测骨折后接受手术治疗患者发生异位骨化(heterotopicossification, HO)风险的nomogram临床评分 系统。方法•选取2018年8月至2020年10月在浙江省舟山医院骨科或脑外科住院的骨折并接受手术的患者共124例, 其中 男性81例, 女性43例, 年龄25〜91岁［平均年龄(56.48±15.45)岁］。收集患者入院临床资料, 包括性别、年龄、是否合 并脑外伤、麻醉方式、手术持续时间、术中出血量等。采集患者骨折后1d、7d、15d共3个时间点的外周血, ELISA法检测 血清骨成形蛋白 2 (bone morphogenetic protein 2, BMP-2)、BMP-4、BMP-5、BMP-7及细胞因子白介素-4 (interleukin 4, IL-4)、IL-6、IL-10、丫干扰素(interferon y, IFN-丫)、转化生长因子-卩(transforming growth factor-p, TGF-p)的浓度。按 随访结果将患者分为可见HO组和未见HO组, 以0=0.15从临床和实验室指征中挑选2组间差异具有统计学意义的变量纳入 单变量Cox回归模型;再以0=0.05从单变量Cox回归模型中挑选变量纳入多变量Cox回归模型来筛选患者发生异位骨化的 独立风险因子, 并计算风险率(HR);最后通过R语言中的rms包进行nomogram可视化输出。结果•随访共发现13例异位 骨化患者, 随访发现时间中位数为71 (38, 292) d。通过组间比较、单变量Cox回归分析、多变量Cox回归分析得到合并 脑外伤(HR=2.932, P=0.038),手术持续时间(HR=1.005, P=0.007),术中出血量(HR=1.004, P=0.022), 15 d时的 BMP-2 (HR=1.009, P=0.044)、BMP-4 (HR=1.004, P=0.011)、TGF-p (HR=1.011, P=0.046),以及7d时的BMP-7 (HR= 1.004, P=0.008)共7个对异位骨化结局有显著影响的独立因子并输出得到骨折后90d、180 d. 360 d患者异位骨化发生概 率预测的nomogram评分系统。结论•预测骨折后手术患者异位骨化风险的nomogram评分系统的7个评分指标分别为是否 合并脑外伤, 手术持续时间, 术中出血量, 骨折后15d外周血BMP-2、BMP-4、TGF-p水平, 以及骨折后7d外周血BMP-7 水平. Objective* To establish a nomogram scoring system to predict morbidity of heterotopic ossification (HO) in the patients undergoing surgery after fracture. Methods • From August 2018 to October 2020, 124 patients with fractures from department of orthopaedics or brain surgery, including 81 males and 43 females with an average age of (56.48±15.45) years old (ranging from 25-91 years old), were enrolled in the study. Clinical features including gender, age, with brain trauma or not, anesthetic mode, operation duration time, and blood loss during operation were collected. Peripheral blood samples were collected at three time points, i.e. 1 d, 7 d and 15 d after fracture, and the sera levels of bone morphogenetic protein 2 (BMP-2), BMP-4, BMP-5, BMP-7, interleukin 4 (IL-4), IL-6, IL-10, interferon y (IFN-y), and transforming growth factor-p (TGF-p) were detected by ELISA. All the patients were divided into HO group and non-HO group according to follow-up outcomes. The variables with statistically significant differences (a =0.15) between the two groups selected from clinical and laboratory indications were included in the univariate Cox regression model. Then the variables selected from univariate Cox regression model (a =0.05) were incorporated into multivariate Cox regression model to screen the independent risk factors of HO and calculate the risk ratios (HR). Finally, the nomogram scoring system was output through rms package in R language. Results • The follow-up observation found 13 HO cases after a median time of 71 (38, 292) d. Seven independent risk factors for HO, i. e. brain trauma (HR=2.932, P=0.038), operation duration time (HR= 1.005, P=0.007), blood loss during operation (HR=1.004, P=0.022), BMP-2 (15d) (HR=1.009, P=0.044), BMP-4 (15 d) (HR=1.004, P=0.011), TGF-卩(15 d) (HR=1.011, P=0.046), and BMP-7 (7 d) (HR=1.004, P=0.008), were selected by comparison between groups, univariate COX regression and multivariate COX regression sequentially. The nomogram to predict morbidity of HO after 90 d, 180 d, and 360 d was generated. Conclusion • The seven scoring indexes of nomogram scoring system for predicting the risk of HO in the patients undergoing surgery after fracture are with brain trauma or not, operation duration time, blood loss during operation, levels of BMP-2, BMP-4 and TGF-卩 in peripheral blood 15 d after fracture and BMP-7 7 d after fracture. [ABSTRACT FROM AUTHOR]

Nonalcoholic fatty liver disease（NAFLD） is considered the liver manifestation of metabolic syndrome and is closely associated with the development and progression of colorectal neoplasms. This article reviews the association of NAFLD with colorectal adenoma（CRA） and colorectal cancer（CRC） and possible mechanism, and it is believed that NAFLD promotes the development of CRA and CRC and affects their prognosis, and various factors, such as insulin resistance, adipocytokine, inflammatory response, intestinal flora, and immunity, may be involved in this process. [ABSTRACT FROM AUTHOR]

In order to clarify the possible cumulative dietary intake risk of triazole pesticide residues in vegetables, the residues distribution of 8 triazole pesticides in 1612 batches of vegetable samples from 5 regions of Jiangsu Province, Zhejiang Province, Shanghai, Anhui Province and Fujian Province were analyzed based on the triazole pesticide residues data obtained from the detection of vegetable samples.The relative potency factor method, the Monte Carlo simulation technique and the Bootstrap sampling technique of probability assessment method were used to evaluate the acute and chronic risk of triazole pesticide intake from vegetables in the target population. The results showed that the most frequently detected pesticides and product combinations were difenoconazole in celery and tomato, and the detection rates reached 23.1% and 20.4%, respectively. Other pesticides with high detection rates were triadimefon,tebuconazole, flusilazole, diniconazole, propiconazole, imazalil and myclobutanil. Among all kinds of vegetables, cucumber contributed the most to the cumulative exposure of different populations, ranging from 50% to 70%. At the 97.5 th percentile, the cumulative chronic exposure of triazole pesticides in vegetables to people of all ages was lower than the chronic reference dose（ADI）, and the cumulative chronic dietary intake risk quotient of infants aged 0-35 months was the highest, with an average of34.6%, but still less than 100%. At the 99.9 th percentile, the cumulative acute exposure of triazole pesticides in vegetables to people of all ages was lower than the acute reference dose（ARfD）, and the cumulative acute dietary intake risk quotient of infants aged from 0 to 35 months was the highest, with an average of 51.7%, but also less than 100%. The study indicated that the cumulative acute and chronic dietary intake risks of triazole pesticide residues in vegetables in Jiangsu, Zhejiang, Shanghai, Anhui and Fujian were all within acceptable limits. [ABSTRACT FROM AUTHOR]

Aiming at the problem of land subsidence in Weibei Plain, a three-dimensional numerical model of fluid-solid coupling for Weibei Plain land subsidence was established. The development law of Weibei Plain land subsidence in the future was discussed from a macro perspective, and the negative impact of groundwater exploitation on the ground subsidence was quantified by taking into account the mutual relationship between groundwater exploitation and land subsidence. The results show that the subsidence funnel center is mainly distributed in the east of Yingli Town and the north of Guangling Township. If the amount of groundwater exploitation in 2019 is maintained, the subsidence of Weibei Plain will continue to develop and increase in the next 10 years, and the maximum cumulative land subsidence will be as high as 565.42 mm in 2029, with an average annual growth rate of 38.97 mm/a, and the subsidence center will remain unchanged. With the decrease of groundwater exploitation, the development degree of land subsidence can be alleviated obviously, and will continue to decrease, causing the mitigation trend of land subsidence. When the reduction is controlled between 10% and 30%, the mitigation effect of land subsidence disaster could be better. [ABSTRACT FROM AUTHOR]