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304. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Author

Wang, Zhaoming, Zhu, Bin, Zhang, Mingfeng, Parikh, Hemang, Jia, Jinping, Chung, Charles C., Sampson, Joshua N., Hoskins, Jason W., Hutchinson, Amy, Burdette, Laurie, Ibrahim, Abdisamad, Hautman, Christopher, Raj, Preethi S., Abnet, Christian C., Adjei, Andrew A., Ahlbom, Anders, Albanes, Demetrius, Allen, Naomi E., Ambrosone, Christine B., Aldrich, Melinda, Amiano, Pilar, Amos, Christopher, Andersson, Ulrika, Andriole, Gerald, Jr, Andrulis, Irene L., Arici, Cecilia, Arslan, Alan A., Austin, Melissa A., Baris, Dalsu, Barkauskas, Donald A., Bassig, Bryan A., Beane Freeman, Laura E., Berg, Christine D., Berndt, Sonja I., Bertazzi, Pier Alberto, Biritwum, Richard B., Black, Amanda, Blot, William, Boeing, Heiner, Boffetta, Paolo, Bolton, Kelly, Boutron-Ruault, Marie-Christine, Bracci, Paige M., Brennan, Paul, Brinton, Louise A., Brotzman, Michelle, Bueno-de-Mesquita, H. Bas, Buring, Julie E., Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Cao, Guangwen, Caporaso, Neil E., Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chang, Gee-Chen, Chang, I-Shou, Chang-Claude, Jenny, Che, Xu, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chung-Hsing, Chen, Constance, Chen, Kuan-Yu, Chen, Yuh-Min, Chokkalingam, Anand P., Chu, Lisa W., Clavel-Chapelon, Francoise, Colditz, Graham A., Colt, Joanne S., Conti, David, Cook, Michael B., Cortessis, Victoria K., Crawford, E. David, Cussenot, Olivier, Davis, Faith G., De Vivo, Immaculata, Deng, Xiang, Ding, Ti, Dinney, Colin P., Di Stefano, Anna Luisa, Diver, W. Ryan, Duell, Eric J., Elena, Joanne W., Fan, Jin-Hu, Feigelson, Heather Spencer, Feychting, Maria, Figueroa, Jonine D., Flanagan, Adrienne M., Fraumeni, Joseph F., Jr, Freedman, Neal D., Fridley, Brooke L., Fuchs, Charles S., Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M., Garcia-Closas, Montserrat, Garcia-Closas, Reina, Gastier-Foster, Julie M., Gaziano, J. Michael, Gerhard, Daniela S., Giffen, Carol A., Giles, Graham G., Gillanders, Elizabeth M., Giovannucci, Edward L., Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M., Gonzalez, Carlos, Gorlick, Richard, Greene, Mark H., Gross, Myron, Grossman, H. Barton, Grubb, Robert, III, Gu, Jian, Guan, Peng, Haiman, Christopher A., Hallmans, Goran, Hankinson, Susan E., Harris, Curtis C., Hartge, Patricia, Hattinger, Claudia, Hayes, Richard B., He, Qincheng, Helman, Lee, Henderson, Brian E., Henriksson, Roger, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holly, Elizabeth A., Hong, Yun-Chul, Hoover, Robert N., Hosgood, H. Dean, III, Hsiao, Chin-Fu, Hsing, Ann W., Hsiung, Chao Agnes, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Hunter, David J., Inskip, Peter D., Ito, Hidemi, Jacobs, Eric J., Jacobs, Kevin B., Jenab, Mazda, Ji, Bu-Tian, Johansen, Christoffer, Johansson, Mattias, Johnson, Alison, Kaaks, Rudolf, Kamat, Ashish M., Kamineni, Aruna, Karagas, Margaret, Khanna, Chand, Khaw, Kay-Tee, Kim, Christopher, Kim, In-Sam, Kim, Jin Hee, Kim, Yeul Hong, Kim, Young-Chul, Kim, Young Tae, Kang, Chang Hyun, Jung, Yoo Jin, Kitahara, Cari M., Klein, Alison P., Klein, Robert, Kogevinas, Manolis, Koh, Woon-Puay, Kohno, Takashi, Kolonel, Laurence N., Kooperberg, Charles, Kratz, Christian P., Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C., Kurucu, Nilgun, Lan, Qing, Lathrop, Mark, Lau, Ching C., Lecanda, Fernando, Lee, Kyoung-Mu, Lee, Maxwell P., Le Marchand, Loic, Lerner, Seth P., Li, Donghui, Liao, Linda M., Lim, Wei-Yen, Lin, Dongxin, Lin, Jie, Lindstrom, Sara, Linet, Martha S., Lissowska, Jolanta, Liu, Jianjun, Ljungberg, Börje, Lloreta, Josep, Lu, Daru, Ma, Jing, Malats, Nuria, Mannisto, Satu, Marina, Neyssa, Mastrangelo, Giuseppe, Matsuo, Keitaro, McGlynn, Katherine A., McKean-Cowdin, Roberta, McNeill, Lorna H., McWilliams, Robert R., Melin, Beatrice S., Meltzer, Paul S., Mensah, James E., Miao, Xiaoping, Michaud, Dominique S., Mondul, Alison M., Moore, Lee E., Muir, Kenneth, Niwa, Shelley, Olson, Sara H., Orr, Nick, Panico, Salvatore, Park, Jae Yong, Patel, Alpa V., Patino-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H. M., Peplonska, Beata, Peters, Ulrike, Petersen, Gloria M., Picci, Piero, Pike, Malcolm C., Porru, Stefano, Prescott, Jennifer, Pu, Xia, Purdue, Mark P., Qiao, You-Lin, Rajaraman, Preetha, Riboli, Elio, Risch, Harvey A., Rodabough, Rebecca J., Rothman, Nathaniel, Ruder, Avima M., Ryu, Jeong-Seon, Sanson, Marc, Schned, Alan, Schumacher, Fredrick R., Schwartz, Ann G., Schwartz, Kendra L., Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D., Severi, Gianluca, Shen, Hongbing, Shen, Min, Shete, Sanjay, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesumaga, Luis, Sierri, Sabina, Loon Sihoe, Alan Dart, Silverman, Debra T., Simon, Matthias, Southey, Melissa C., Spector, Logan, Spitz, Margaret, Stampfer, Meir, Stattin, Par, Stern, Mariana C., Stevens, Victoria L., Stolzenberg-Solomon, Rachael Z., Stram, Daniel O., Strom, Sara S., Su, Wu-Chou, Sund, Malin, Sung, Sook Whan, Swerdlow, Anthony, Tan, Wen, Tanaka, Hideo, Tang, Wei, Tang, Ze-Zhang, Tardon, Adonina, Tay, Evelyn, Taylor, Philip R., Tettey, Yao, Thomas, David M., Tirabosco, Roberto, Tjonneland, Anne, Tobias, Geoffrey S., Toro, Jorge R., Travis, Ruth C., Trichopoulos, Dimitrios, Troisi, Rebecca, Truelove, Ann, Tsai, Ying-Huang, Tucker, Margaret A., Tumino, Rosario, Van Den Berg, David, Van Den Eeden, Stephen K., Vermeulen, Roel, Vineis, Paolo, Visvanathan, Kala, Vogel, Ulla, Wang, Chaoyu, Wang, Chengfeng, Wang, Junwen, Wang, Sophia S., Weiderpass, Elisabete, Weinstein, Stephanie J., Wentzensen, Nicolas, Wheeler, William, White, Emily, Wiencke, John K., Wolk, Alicja, Wolpin, Brian M., Wong, Maria Pik, Wrensch, Margaret, Wu, Chen, Wu, Tangchun, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S., Xiang, Yong-Bing, Xu, Jun, Yang, Hannah P., Yang, Pan-Chyr, Yatabe, Yasushi, Ye, Yuanqing, Yeboah, Edward D., Yin, Zhihua, Ying, Chen, Yu, Chong-Jen, Yu, Kai, Yuan, Jian-Min, Zanetti, Krista A., Zeleniuch-Jacquotte, Anne, Zheng, Wei, Zhou, Baosen, Mirabello, Lisa, Savage, Sharon A., Kraft, Peter, Chanock, Stephen J., Yeager, Meredith, Landi, Maria Terese, Shi, Jianxin, Chatterjee, Nilanjan, and Amundadottir, Laufey T.

Published
2014
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305. Cigarette smoking and risk of ovarian cancer: a pooled analysis of 21 case–control studies

Author

Faber, Mette T., Kjær, Susanne K., Dehlendorff, Christian, Chang-Claude, Jenny, Andersen, Klaus K., Høgdall, Estrid, Webb, Penelope M., Jordan, Susan J., Rossing, Mary Anne, Doherty, Jennifer A., Lurie, Galina, Thompson, Pamela J., Carney, Michael E., Goodman, Marc T., Ness, Roberta B., Modugno, Francesmary, Edwards, Robert P., Bunker, Clareann H., Goode, Ellen L., Fridley, Brooke L., Vierkant, Robert A., Larson, Melissa C., Schildkraut, Joellen, Cramer, Daniel W., Terry, Kathryn L., Vitonis, Allison F., Bandera, Elisa V., Olson, Sara H., King, Melony, Chandran, Urmila, Kiemeney, Lambertus A., Massuger, Leon F. A. G., van Altena, Anne M., Vermeulen, Sita H., Brinton, Louise, Wentzensen, Nicolas, Lissowska, Jolanta, Yang, Hannah P., Moysich, Kirsten B., Odunsi, Kunle, Kasza, Karin, Odunsi-Akanji, Oluwatosin, Song, Honglin, Pharaoh, Paul, Shah, Mitul, Whittemore, Alice S., McGuire, Valerie, Sieh, Weiva, Sutphen, Rebecca, Menon, Usha, Gayther, Simon A., Ramus, Susan J., Gentry-Maharaj, Aleksandra, Pearce, Celeste Leigh, Wu, Anna H., Pike, Malcolm C., Risch, Harvey A., Jensen, Allan, The Australian Cancer Study (Ovarian Cancer), Australian Ovarian Cancer Study Group, and On behalf of the Ovarian Cancer Association Consortium

Published
2013
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307. Association of Endogenous Pregnenolone, Progesterone, and Related Metabolites with Risk of Endometrial and Ovarian Cancers in Postmenopausal Women: The B∼FIT Cohort

Author

Trabert, Britton, primary, Geczik, Ashley M., additional, Bauer, Doug C., additional, Buist, Diana S.M., additional, Cauley, Jane A., additional, Falk, Roni T., additional, Gierach, Gretchen L., additional, Hue, Trisha F., additional, Lacey, James V., additional, LaCroix, Andrea Z., additional, Michels, Kara A., additional, Tice, Jeffrey A., additional, Xu, Xia, additional, Brinton, Louise A., additional, and Dallal, Cher M., additional

Published
2021
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308. Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women

Author

Clendenen, Tess V, primary, Ge, Wenzhen, additional, Koenig, Karen L, additional, Afanasyeva, Yelena, additional, Agnoli, Claudia, additional, Bertone-Johnson, Elizabeth, additional, Brinton, Louise A, additional, Darvishian, Farbod, additional, Dorgan, Joanne F, additional, Eliassen, A Heather, additional, Falk, Roni T, additional, Hallmans, Göran, additional, Hankinson, Susan E, additional, Hoffman-Bolton, Judith, additional, Key, Timothy J, additional, Krogh, Vittorio, additional, Nichols, Hazel B, additional, Sandler, Dale P, additional, Schoemaker, Minouk J, additional, Sluss, Patrick M, additional, Sund, Malin, additional, Swerdlow, Anthony J, additional, Visvanathan, Kala, additional, Liu, Mengling, additional, and Zeleniuch-Jacquotte, Anne, additional

Published
2021
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309. Pregnancy outcomes and risk of endometrial cancer: A pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium

Author

Jordan, Susan J., Jordan, Susan J., Na, Renhua, Weiderpass, Elisabete, Adami, Hans-Olov, Anderson, Kristin E., van den Brandt, Piet A., Brinton, Louise A., Chen, Chu, Cook, Linda S., Doherty, Jennifer A., Du, Mengmeng, Friedenreich, Christine M., Gierach, Gretchen L., Goodman, Marc T., Krogh, Vittorio, Levi, Fabio, Lu, Lingeng, Miller, Anthony B., McCann, Susan E., Moysich, Kirsten B., Negri, Eva, Olson, Sara H., Petruzella, Stacey, Palmer, Julie R., Parazzini, Fabio, Pike, Malcolm C., Prizment, Anna E., Rebbeck, Timothy R., Reynolds, Peggy, Ricceri, Fulvio, Risch, Harvey A., Rohan, Thomas E., Sacerdote, Carlotta, Schouten, Leo J., Serraino, Diego, Setiawan, Veronica W., Shu, Xiao-Ou, Sponholtz, Todd R., Spurdle, Amanda B., Stolzenberg-Solomon, Rachael Z., Trabert, Britton, Wentzensen, Nicolas, Wilkens, Lynne R., Wise, Lauren A., Yu, Herbert, La Vecchia, Carlo, De Vivo, Immaculata, Xu, Wanghong, Zeleniuch-Jacquotte, Anne, Webb, Penelope M., Jordan, Susan J., Jordan, Susan J., Na, Renhua, Weiderpass, Elisabete, Adami, Hans-Olov, Anderson, Kristin E., van den Brandt, Piet A., Brinton, Louise A., Chen, Chu, Cook, Linda S., Doherty, Jennifer A., Du, Mengmeng, Friedenreich, Christine M., Gierach, Gretchen L., Goodman, Marc T., Krogh, Vittorio, Levi, Fabio, Lu, Lingeng, Miller, Anthony B., McCann, Susan E., Moysich, Kirsten B., Negri, Eva, Olson, Sara H., Petruzella, Stacey, Palmer, Julie R., Parazzini, Fabio, Pike, Malcolm C., Prizment, Anna E., Rebbeck, Timothy R., Reynolds, Peggy, Ricceri, Fulvio, Risch, Harvey A., Rohan, Thomas E., Sacerdote, Carlotta, Schouten, Leo J., Serraino, Diego, Setiawan, Veronica W., Shu, Xiao-Ou, Sponholtz, Todd R., Spurdle, Amanda B., Stolzenberg-Solomon, Rachael Z., Trabert, Britton, Wentzensen, Nicolas, Wilkens, Lynne R., Wise, Lauren A., Yu, Herbert, La Vecchia, Carlo, De Vivo, Immaculata, Xu, Wanghong, Zeleniuch-Jacquotte, Anne, and Webb, Penelope M.

Abstract

A full-term pregnancy is associated with reduced endometrial cancer risk; however, whether the effect of additional pregnancies is independent of age at last pregnancy is unknown. The associations between other pregnancy-related factors and endometrial cancer risk are less clear. We pooled individual participant data from 11 cohort and 19 case-control studies participating in the Epidemiology of Endometrial Cancer Consortium (E2C2) including 16 986 women with endometrial cancer and 39 538 control women. We used one- and two-stage meta-analytic approaches to estimate pooled odds ratios (ORs) for the association between exposures and endometrial cancer risk. Ever having a full-term pregnancy was associated with a 41% reduction in risk of endometrial cancer compared to never having a full-term pregnancy (OR = 0.59, 95% confidence interval [CI] 0.56-0.63). The risk reduction appeared the greatest for the first full-term pregnancy (OR = 0.78, 95% CI 0.72-0.84), with a further similar to 15% reduction per pregnancy up to eight pregnancies (OR = 0.20, 95% CI 0.14-0.28) that was independent of age at last full-term pregnancy. Incomplete pregnancy was also associated with decreased endometrial cancer risk (7%-9% reduction per pregnancy). Twin births appeared to have the same effect as singleton pregnancies. Our pooled analysis shows that, while the magnitude of the risk reduction is greater for a full-term pregnancy than an incomplete pregnancy, each additional pregnancy is associated with further reduction in endometrial cancer risk, independent of age at last full-term pregnancy. These results suggest that the very high progesterone level in the last trimester of pregnancy is not the sole explanation for the protective effect of pregnancy.

Published
2021

310. Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer

Author

Kho, Pik Fang, Amant, Frederic, Annibali, Daniela, Ashton, Katie, Attia, John, Auer, Paul L., Beckmann, Matthias W., Black, Amanda, Brinton, Louise, Buchanan, Daniel D., Chanock, Stephen J., Chen, Chu, Chen, Maxine M., Cheng, Timothy H.T., Cook, Linda S., Crous-Bous, Marta, Czene, Kamila, De Vivo, Immaculata, Dennis, Joe, Dörk, Thilo, Dowdy, Sean C., Dunning, Alison M., Dürst, Matthias, Easton, Douglas F., Ekici, Arif B., Fasching, Peter A., Fridley, Brooke L., Friedenreich, Christine M., García-Closas, Montserrat, Gaudet, Mia M., Giles, Graham G., Goode, Ellen L., Gorman, Maggie, Haiman, Christopher A., Hall, Per, Hankinson, Susan E., Hein, Alexander, Hillemanns, Peter, Hodgson, Shirley, Hoivik, Erling A., Holliday, Elizabeth G., Hunter, David J., Jones, Angela M., Kraft, Peter, Krakstad, Camilla, Lambrechts, Diether, Le Marchand, Loic, Liang, Xiaolin, Lindblom, Annika, Lissowska, Jolanta, Long, Jirong, Lu, Lingeng, Magliocco, Anthony M., Martin, Lynn, McEvoy, Mark, Milne, Roger L., Mints, Miriam, Nassir, Rami, Otton, Geoffrey, Palles, Claire, Pooler, Loreall, Proietto, Tony, Rebbeck, Timothy R., Renner, Stefan P., Risch, Harvey A., Rübner, Matthias, Runnebaum, Ingo, Sacerdote, Carlotta, Sarto, Gloria E., Schumacher, Fredrick, Scott, Rodney J., Setiawan, V. Wendy, Shah, Mitul, Sheng, Xin, Shu, Xiao Ou, Southey, Melissa C., Tham, Emma, Tomlinson, Ian, Trovik, Jone, Turman, Constance, Tyrer, Jonathan P., Van Den Berg, David, Wang, Zhaoming, Wentzensen, Nicolas, Xia, Lucy, Xiang, Yong Bing, Yang, Hannah P., Yu, Herbert, Zheng, Wei, Webb, Penelope M., Thompson, Deborah J., Spurdle, Amanda B., Glubb, Dylan M., O'Mara, Tracy A., Kho, Pik Fang, Amant, Frederic, Annibali, Daniela, Ashton, Katie, Attia, John, Auer, Paul L., Beckmann, Matthias W., Black, Amanda, Brinton, Louise, Buchanan, Daniel D., Chanock, Stephen J., Chen, Chu, Chen, Maxine M., Cheng, Timothy H.T., Cook, Linda S., Crous-Bous, Marta, Czene, Kamila, De Vivo, Immaculata, Dennis, Joe, Dörk, Thilo, Dowdy, Sean C., Dunning, Alison M., Dürst, Matthias, Easton, Douglas F., Ekici, Arif B., Fasching, Peter A., Fridley, Brooke L., Friedenreich, Christine M., García-Closas, Montserrat, Gaudet, Mia M., Giles, Graham G., Goode, Ellen L., Gorman, Maggie, Haiman, Christopher A., Hall, Per, Hankinson, Susan E., Hein, Alexander, Hillemanns, Peter, Hodgson, Shirley, Hoivik, Erling A., Holliday, Elizabeth G., Hunter, David J., Jones, Angela M., Kraft, Peter, Krakstad, Camilla, Lambrechts, Diether, Le Marchand, Loic, Liang, Xiaolin, Lindblom, Annika, Lissowska, Jolanta, Long, Jirong, Lu, Lingeng, Magliocco, Anthony M., Martin, Lynn, McEvoy, Mark, Milne, Roger L., Mints, Miriam, Nassir, Rami, Otton, Geoffrey, Palles, Claire, Pooler, Loreall, Proietto, Tony, Rebbeck, Timothy R., Renner, Stefan P., Risch, Harvey A., Rübner, Matthias, Runnebaum, Ingo, Sacerdote, Carlotta, Sarto, Gloria E., Schumacher, Fredrick, Scott, Rodney J., Setiawan, V. Wendy, Shah, Mitul, Sheng, Xin, Shu, Xiao Ou, Southey, Melissa C., Tham, Emma, Tomlinson, Ian, Trovik, Jone, Turman, Constance, Tyrer, Jonathan P., Van Den Berg, David, Wang, Zhaoming, Wentzensen, Nicolas, Xia, Lucy, Xiang, Yong Bing, Yang, Hannah P., Yu, Herbert, Zheng, Wei, Webb, Penelope M., Thompson, Deborah J., Spurdle, Amanda B., Glubb, Dylan M., and O'Mara, Tracy A.

Abstract

Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies have reported inconsistent associations between blood lipids and cancer risk. To reduce biases from unmeasured confounding, we performed a bidirectional, two-sample Mendelian randomization analysis to investigate the relationship between levels of three blood lipids (low-density lipoprotein [LDL] and high-density lipoprotein [HDL] cholesterol, and triglycerides) and endometrial cancer risk. Genetic variants associated with each of these blood lipid levels (P < 5 × 10−8) were identified as instrumental variables, and assessed using genome-wide association study data from the Endometrial Cancer Association Consortium (12 906 cases and 108 979 controls) and the Global Lipids Genetic Consortium (n = 188 578). Mendelian randomization analyses found genetically raised LDL cholesterol levels to be associated with lower risks of endometrial cancer of all histologies combined, and of endometrioid and non-endometrioid subtypes. Conversely, higher genetically predicted HDL cholesterol levels were associated with increased risk of non-endometrioid endometrial cancer. After accounting for the potential confounding role of obesity (as measured by genetic variants associated with body mass index), the association between genetically predicted increased LDL cholesterol levels and lower endometrial cancer risk remained significant, especially for non-endometrioid endometrial cancer. There was no evidence to support a role for triglycerides in endometrial cancer development. Our study supports a role for LDL and HDL cholesterol in the development of non-endometrioid endometrial cancer. Further studies are required to understand the mechanisms underlying these findings.

Published
2021

311. Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women

Author

Clendenen, Tess V., Ge, Wenzhen, Koenig, Karen L., Afanasyeva, Yelena, Agnoli, Claudia, Bertone-Johnson, Elizabeth, Brinton, Louise A., Darvishian, Farbod, Dorgan, Joanne F., Eliassen, A. Heather, Falk, Roni T., Hallmans, Göran, Hankinson, Susan E., Hoffman-Bolton, Judith, Key, Timothy J., Krogh, Vittorio, Nichols, Hazel B., Sandler, Dale P., Schoemaker, Minouk J., Sluss, Patrick M., Sund, Malin, Swerdlow, Anthony J., Visvanathan, Kala, Liu, Mengling, Zeleniuch-Jacquotte, Anne, Clendenen, Tess V., Ge, Wenzhen, Koenig, Karen L., Afanasyeva, Yelena, Agnoli, Claudia, Bertone-Johnson, Elizabeth, Brinton, Louise A., Darvishian, Farbod, Dorgan, Joanne F., Eliassen, A. Heather, Falk, Roni T., Hallmans, Göran, Hankinson, Susan E., Hoffman-Bolton, Judith, Key, Timothy J., Krogh, Vittorio, Nichols, Hazel B., Sandler, Dale P., Schoemaker, Minouk J., Sluss, Patrick M., Sund, Malin, Swerdlow, Anthony J., Visvanathan, Kala, Liu, Mengling, and Zeleniuch-Jacquotte, Anne

Abstract

Context: We previously reported that anti-Müllerian hormone (AMH), a marker of ovarian reserve, is positively associated with breast cancer risk, consistent with other studies. Objective: This study assessed whether risk factors for breast cancer are correlates of AMH concentration. Methods: This cross-sectional study included 3831 healthy premenopausal women (aged 21-57, 87% aged 35-49) from 10 cohort studies among the general population. Results: Adjusting for age and cohort, AMH positively associated with age at menarche (P < 0.0001) and parity (P = 0.0008) and inversely associated with hysterectomy/partial oophorectomy (P = 0.0008). Compared with women of normal weight, AMH was lower (relative geometric mean difference 27%, P < 0.0001) among women who were obese. Current oral contraceptive (OC) use and current/former smoking were associated with lower AMH concentration than never use (40% and 12% lower, respectively, P < 0.0001). We observed higher AMH concentrations among women who had had a benign breast biopsy (15% higher, P = 0.03), a surrogate for benign breast disease, an association that has not been reported. In analyses stratified by age (<40 vs ≥40), associations of AMH with body mass index and OCs were similar in younger and older women, while associations with the other factors (menarche, parity, hysterectomy/partial oophorectomy, smoking, and benign breast biopsy) were limited to women ≥40 (P-interaction < 0.05). Conclusion: This is the largest study of AMH and breast cancer risk factors among women from the general population (not presenting with infertility), and it suggests that most associations are limited to women over 40, who are approaching menopause and whose AMH concentration is declining.

Published
2021
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312. Associations of fecal microbial profiles with breast cancer and nonmalignant breast disease in the Ghana Breast Health Study.

Author

Byrd, Doratha A, Byrd, Doratha A, Vogtmann, Emily, Wu, Zeni, Han, Yongli, Wan, Yunhu, Clegg-Lamptey, Joe-Nat, Yarney, Joel, Wiafe-Addai, Beatrice, Wiafe, Seth, Awuah, Baffour, Ansong, Daniel, Nyarko, Kofi, Hullings, Autumn G, Hua, Xing, Ahearn, Thomas, Goedert, James J, Shi, Jianxin, Knight, Rob, Figueroa, Jonine D, Brinton, Louise A, Garcia-Closas, Montserrat, Sinha, Rashmi, Byrd, Doratha A, Byrd, Doratha A, Vogtmann, Emily, Wu, Zeni, Han, Yongli, Wan, Yunhu, Clegg-Lamptey, Joe-Nat, Yarney, Joel, Wiafe-Addai, Beatrice, Wiafe, Seth, Awuah, Baffour, Ansong, Daniel, Nyarko, Kofi, Hullings, Autumn G, Hua, Xing, Ahearn, Thomas, Goedert, James J, Shi, Jianxin, Knight, Rob, Figueroa, Jonine D, Brinton, Louise A, Garcia-Closas, Montserrat, and Sinha, Rashmi

Abstract

The gut microbiota may play a role in breast cancer etiology by regulating hormonal, metabolic and immunologic pathways. We investigated associations of fecal bacteria with breast cancer and nonmalignant breast disease in a case-control study conducted in Ghana, a country with rising breast cancer incidence and mortality. To do this, we sequenced the V4 region of the 16S rRNA gene to characterize bacteria in fecal samples collected at the time of breast biopsy (N = 379 breast cancer cases, N = 102 nonmalignant breast disease cases, N = 414 population-based controls). We estimated associations of alpha diversity (observed amplicon sequence variants [ASVs], Shannon index, and Faith's phylogenetic diversity), beta diversity (Bray-Curtis and unweighted/weighted UniFrac distance), and the presence and relative abundance of select taxa with breast cancer and nonmalignant breast disease using multivariable unconditional polytomous logistic regression. All alpha diversity metrics were strongly, inversely associated with odds of breast cancer and for those in the highest relative to lowest tertile of observed ASVs, the odds ratio (95% confidence interval) was 0.21 (0.13-0.36; Ptrend < .001). Alpha diversity associations were similar for nonmalignant breast disease and breast cancer grade/molecular subtype. All beta diversity distance matrices and multiple taxa with possible estrogen-conjugating and immune-related functions were strongly associated with breast cancer (all Ps < .001). There were no statistically significant differences between breast cancer and nonmalignant breast disease cases in any microbiota metric. In conclusion, fecal bacterial characteristics were strongly and similarly associated with breast cancer and nonmalignant breast disease. Our findings provide novel insight into potential microbially-mediated mechanisms of breast disease.

Published
2021

313. Endogenous Progestogens and Colorectal Cancer Risk among Postmenopausal Women.

Author

Michels, Kara A, Michels, Kara A, Geczik, Ashley M, Bauer, Doug C, Brinton, Louise A, Buist, Diana SM, Cauley, Jane A, Dallal, Cher M, Falk, Roni T, Hue, Trisha F, Lacey, James V, LaCroix, Andrea Z, Tice, Jeffrey A, Xu, Xia, Trabert, Britton, Michels, Kara A, Michels, Kara A, Geczik, Ashley M, Bauer, Doug C, Brinton, Louise A, Buist, Diana SM, Cauley, Jane A, Dallal, Cher M, Falk, Roni T, Hue, Trisha F, Lacey, James V, LaCroix, Andrea Z, Tice, Jeffrey A, Xu, Xia, and Trabert, Britton

Abstract

BackgroundThe role of progestogens in colorectal cancer development is poorly characterized. To address this, our group developed a highly sensitive assay to measure concentrations of seven markers of endogenous progestogen metabolism among postmenopausal women.MethodsThe markers were measured in baseline serum collected from postmenopausal women in a case-cohort study within the breast and bone follow-up to the fracture intervention trial (B∼FIT). We followed women not using exogenous hormones at baseline (1992-1993) for up to 12 years: 187 women with incident colorectal cancer diagnosed during follow-up and a subcohort of 495 women selected on strata of age and clinical center. We used adjusted Cox regression models with robust variance to estimate risk for colorectal cancer [hazard ratios (HR), 95% confidence intervals (CI)].ResultsHigh concentrations of pregnenolone and progesterone were not associated with colorectal cancer [quintile(Q)5 versus Q1: pregnenolone HR, 0.71, 95% CI, 0.40-1.25; progesterone HR, 1.25; 95% CI, 0.71-2.22]. A trend of increasing risk was suggested, but statistically imprecise across quintiles of 17-hydroxypregnenolone (Q2 to Q5 HRs, 0.75-1.44; P trend, 0.06).ConclusionsWe used sensitive and reliable assays to measure multiple circulating markers of progestogen metabolism. Progestogens were generally unassociated with colorectal cancer risk in postmenopausal women.ImpactOur findings are consistent with most prior research on circulating endogenous sex hormones, which taken together suggest that sex hormones may not be major drivers of colorectal carcinogenesis in postmenopausal women.

Published
2021

314. Association of Endogenous Pregnenolone, Progesterone, and Related Metabolites with Risk of Endometrial and Ovarian Cancers in Postmenopausal Women: The B∼FIT Cohort.

Author

Trabert, Britton, Trabert, Britton, Geczik, Ashley M, Bauer, Doug C, Buist, Diana SM, Cauley, Jane A, Falk, Roni T, Gierach, Gretchen L, Hue, Trisha F, Lacey, James V, LaCroix, Andrea Z, Michels, Kara A, Tice, Jeffrey A, Xu, Xia, Brinton, Louise A, Dallal, Cher M, Trabert, Britton, Trabert, Britton, Geczik, Ashley M, Bauer, Doug C, Buist, Diana SM, Cauley, Jane A, Falk, Roni T, Gierach, Gretchen L, Hue, Trisha F, Lacey, James V, LaCroix, Andrea Z, Michels, Kara A, Tice, Jeffrey A, Xu, Xia, Brinton, Louise A, and Dallal, Cher M

Abstract

BackgroundPostmenopausal pregnenolone and/or progesterone levels in relation to endometrial and ovarian cancer risks have been infrequently evaluated. To address this, we utilized a sensitive and reliable assay to quantify prediagnostic levels of seven markers related to endogenous hormone metabolism.MethodsHormones were quantified in baseline serum collected from postmenopausal women in a cohort study nested within the Breast and Bone Follow-up to the Fracture Intervention Trial (B∼FIT). Women using exogenous hormones at baseline (1992-1993) were excluded. Incident endometrial (n = 65) and ovarian (n = 67) cancers were diagnosed during 12 follow-up years and compared with a subcohort of 345 women (no hysterectomy) and 413 women (no oophorectomy), respectively. Cox models with robust variance were used to estimate cancer risk.ResultsCirculating progesterone levels were not associated with endometrial [tertile (T)3 vs. T1 HR (95% confidence interval): 1.87 (0.85-4.11); P trend = 0.17] or ovarian cancer risk [1.16 (0.58-2.33); 0.73]. Increasing levels of the progesterone-to-estradiol ratio were inversely associated with endometrial cancer risk [T3 vs. T1: 0.29 (0.09-0.95); 0.03]. Increasing levels of 17-hydroxypregnenolone were inversely associated with endometrial cancer risk [0.40 (0.18-0.91); 0.03] and positively associated with ovarian cancer risk [3.11 (1.39-6.93); 0.01].ConclusionsUsing sensitive and reliable assays, this study provides novel data that endogenous progesterone levels are not strongly associated with incident endometrial or ovarian cancer risks. 17-hydroxypregnenolone was positively associated with ovarian cancer and inversely associated with endometrial cancer.ImpactWhile our results require replication in large studies, they provide further support of the hormonal etiology of endometrial and ovarian cancers.

Published
2021

315. Cross-Cancer Genome-Wide Association Study of Endometrial Cancer and Epithelial Ovarian Cancer Identifies Genetic Risk Regions Associated with Risk of Both Cancers

Author

Glubb, Dylan M, Glubb, Dylan M, Thompson, Deborah J, Aben, Katja KH, Alsulimani, Ahmad, Amant, Frederic, Annibali, Daniela, Attia, John, Barricarte, Aurelio, Beckmann, Matthias W, Berchuck, Andrew, Bermisheva, Marina, Bernardini, Marcus Q, Bischof, Katharina, Bjorge, Line, Bodelon, Clara, Brand, Alison H, Brenton, James D, Brinton, Louise A, Bruinsma, Fiona, Buchanan, Daniel D, Burghaus, Stefanie, Butzow, Ralf, Cai, Hui, Carney, Michael E, Chanock, Stephen J, Chen, Chu, Chen, Xiao Qing, Chen, Zhihua, Cook, Linda S, Cunningham, Julie M, De Vivo, Immaculata, deFazio, Anna, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dunning, Alison M, Dürst, Matthias, Edwards, Todd, Edwards, Robert P, Ekici, Arif B, Ewing, Ailith, Fasching, Peter A, Ferguson, Sarah, Flanagan, James M, Fostira, Florentia, Fountzilas, George, Friedenreich, Christine M, Gao, Bo, Gaudet, Mia M, Gawełko, Jan, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goodman, Marc T, Gronwald, Jacek, Harris, Holly R, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Høgdall, Estrid, Høgdall, Claus K, Holliday, Elizabeth G, Huntsman, David G, Huzarski, Tomasz, Jakubowska, Anna, Jensen, Allan, Jones, Michael E, Karlan, Beth Y, Karnezis, Anthony, Kelley, Joseph L, Khusnutdinova, Elza, Killeen, Jeffrey L, Kjaer, Susanne K, Klapdor, Rüdiger, Köbel, Martin, Konopka, Bozena, Konstantopoulou, Irene, Kopperud, Reidun K, Koti, Madhuri, Kraft, Peter, Kupryjanczyk, Jolanta, Lambrechts, Diether, Larson, Melissa C, Le Marchand, Loic, Lele, Shashikant, Lester, Jenny, Li, Andrew J, Liang, Dong, Liebrich, Clemens, Lipworth, Loren, Lissowska, Jolanta, Lu, Lingeng, Lu, Karen H, Macciotta, Alessandra, Mattiello, Amalia, May, Taymaa, McAlpine, Jessica N, McGuire, Valerie, Glubb, Dylan M, Glubb, Dylan M, Thompson, Deborah J, Aben, Katja KH, Alsulimani, Ahmad, Amant, Frederic, Annibali, Daniela, Attia, John, Barricarte, Aurelio, Beckmann, Matthias W, Berchuck, Andrew, Bermisheva, Marina, Bernardini, Marcus Q, Bischof, Katharina, Bjorge, Line, Bodelon, Clara, Brand, Alison H, Brenton, James D, Brinton, Louise A, Bruinsma, Fiona, Buchanan, Daniel D, Burghaus, Stefanie, Butzow, Ralf, Cai, Hui, Carney, Michael E, Chanock, Stephen J, Chen, Chu, Chen, Xiao Qing, Chen, Zhihua, Cook, Linda S, Cunningham, Julie M, De Vivo, Immaculata, deFazio, Anna, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dunning, Alison M, Dürst, Matthias, Edwards, Todd, Edwards, Robert P, Ekici, Arif B, Ewing, Ailith, Fasching, Peter A, Ferguson, Sarah, Flanagan, James M, Fostira, Florentia, Fountzilas, George, Friedenreich, Christine M, Gao, Bo, Gaudet, Mia M, Gawełko, Jan, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goodman, Marc T, Gronwald, Jacek, Harris, Holly R, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Høgdall, Estrid, Høgdall, Claus K, Holliday, Elizabeth G, Huntsman, David G, Huzarski, Tomasz, Jakubowska, Anna, Jensen, Allan, Jones, Michael E, Karlan, Beth Y, Karnezis, Anthony, Kelley, Joseph L, Khusnutdinova, Elza, Killeen, Jeffrey L, Kjaer, Susanne K, Klapdor, Rüdiger, Köbel, Martin, Konopka, Bozena, Konstantopoulou, Irene, Kopperud, Reidun K, Koti, Madhuri, Kraft, Peter, Kupryjanczyk, Jolanta, Lambrechts, Diether, Larson, Melissa C, Le Marchand, Loic, Lele, Shashikant, Lester, Jenny, Li, Andrew J, Liang, Dong, Liebrich, Clemens, Lipworth, Loren, Lissowska, Jolanta, Lu, Lingeng, Lu, Karen H, Macciotta, Alessandra, Mattiello, Amalia, May, Taymaa, McAlpine, Jessica N, and McGuire, Valerie

Abstract

BackgroundAccumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide association studies (GWAS) for endometrial cancer and ovarian cancer have identified 16 and 27 risk regions, respectively, four of which overlap between the two cancers. We aimed to identify joint endometrial and ovarian cancer risk loci by performing a meta-analysis of GWAS summary statistics from these two cancers.MethodsUsing LDScore regression, we explored the genetic correlation between endometrial cancer and ovarian cancer. To identify loci associated with the risk of both cancers, we implemented a pipeline of statistical genetic analyses (i.e., inverse-variance meta-analysis, colocalization, and M-values) and performed analyses stratified by subtype. Candidate target genes were then prioritized using functional genomic data.ResultsGenetic correlation analysis revealed significant genetic correlation between the two cancers (rG = 0.43, P = 2.66 × 10-5). We found seven loci associated with risk for both cancers (P Bonferroni < 2.4 × 10-9). In addition, four novel subgenome-wide regions at 7p22.2, 7q22.1, 9p12, and 11q13.3 were identified (P < 5 × 10-7). Promoter-associated HiChIP chromatin loops from immortalized endometrium and ovarian cell lines and expression quantitative trait loci data highlighted candidate target genes for further investigation.ConclusionsUsing cross-cancer GWAS meta-analysis, we have identified several joint endometrial and ovarian cancer risk loci and candidate target genes for future functional analysis.ImpactOur research highlights the shared genetic relationship between endometrial cancer and ovarian cancer. Further studies in larger sample sets are required to confirm our findings.

Published
2021

317. Fine mapping of 14q24.1 breast cancer susceptibility locus

Author

Lee, Phoebe, Fu, Yi-Ping, Figueroa, Jonine D., Prokunina-Olsson, Ludmila, Gonzalez-Bosquet, Jesus, Kraft, Peter, Wang, Zhaoming, Jacobs, Kevin B., Yeager, Meredith, Horner, Marie-Josèphe, Hankinson, Susan E., Hutchinson, Amy, Chatterjee, Nilanjan, Garcia-Closas, Montserrat, Ziegler, Regina G., Berg, Christine D., Buys, Saundra S., McCarty, Catherine A., Feigelson, Heather Spencer, Thun, Michael J., Diver, Ryan, Prentice, Ross, Jackson, Rebecca, Kooperberg, Charles, Chlebowski, Rowan, Lissowska, Jolanta, Peplonska, Beata, Brinton, Louise A., Tucker, Margaret, Fraumeni, Jr., Joseph F., Hoover, Robert N., Thomas, Gilles, Hunter, David J., and Chanock, Stephen J.

Published
2012
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319. Expression of TGF-β signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics

Author

Figueroa, Jonine D., Flanders, Kathleen C., Garcia-Closas, Montserrat, Anderson, William F., Yang, Xiaohong R., Matsuno, Rayna K., Duggan, Máire A., Pfeiffer, Ruth M., Ooshima, Akira, Cornelison, Robert, Gierach, Gretchen L., Brinton, Louise A., Lissowska, Jolanta, Peplonska, Beata, Wakefield, Lalage M., and Sherman, Mark E.

Published
2010
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321. Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium

Author

Milne, Roger L., Burwinkel, Barbara, Michailidou, Kyriaki, Arias-Perez, Jose-Ignacio, Zamora, M. Pilar, Menéndez-Rodríguez, Primitiva, Hardisson, David, Mendiola, Marta, González-Neira, Anna, Pita, Guillermo, Alonso, M. Rosario, Dennis, Joe, Wang, Qin, Bolla, Manjeet K., Swerdlow, Anthony, Ashworth, Alan, Orr, Nick, Schoemaker, Minouk, Ko, Yon-Dschun, Brauch, Hiltrud, Hamann, Ute, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Tchatchou, Sandrine, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Tajima, Kazuo, Li, Jingmei, Brand, Judith S., Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, Lambrechts, Diether, Peuteman, Gilian, Christiaens, Marie-Rose, Smeets, Ann, Jakubowska, Anna, Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katazyna, Hartman, Mikael, Hui, Miao, Yen Lim, Wei, Wan Chan, Ching, Marme, Federick, Yang, Rongxi, Bugert, Peter, Lindblom, Annika, Margolin, Sara, García-Closas, Montserrat, Chanock, Stephen J., Lissowska, Jolanta, Figueroa, Jonine D., Bojesen, Stig E., Nordestgaard, Børge G., Flyger, Henrik, Hooning, Maartje J., Kriege, Mieke, van den Ouweland, Ans M.W., Koppert, Linetta B., Fletcher, Olivia, Johnson, Nichola, dos-Santos-Silva, Isabel, Peto, Julian, Zheng, Wei, Deming-Halverson, Sandra, Shrubsole, Martha J., Long, Jirong, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Winqvist, Robert, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Grip, Mervi, Cox, Angela, Cross, Simon S., Reed, Malcolm W.R., Schmidt, Marjanka K., Broeks, Annegien, Cornelissen, Sten, Braaf, Linde, Kang, Daehee, Choi, Ji-Yeob, Park, Sue K., Noh, Dong-Young, Simard, Jacques, Dumont, Martine, Goldberg, Mark S., Labrèche, France, Fasching, Peter A., Hein, Alexander, Ekici, Arif B., Beckmann, Matthias W., Radice, Paolo, Peterlongo, Paolo, Azzollini, Jacopo, Barile, Monica, Sawyer, Elinor, Tomlinson, Ian, Kerin, Michael, Miller, Nicola, Hopper, John L., Schmidt, Daniel F., Makalic, Enes, Southey, Melissa C., Hwang Teo, Soo, Har Yip, Cheng, Sivanandan, Kavitta, Tay, Wan-Ting, Shen, Chen-Yang, Hsiung, Chia-Ni, Yu, Jyh-Cherng, Hou, Ming-Feng, Guénel, Pascal, Truong, Therese, Sanchez, Marie, Mulot, Claire, Blot, William, Cai, Qiuyin, Nevanlinna, Heli, Muranen, Taru A., Aittomäki, Kristiina, Blomqvist, Carl, Wu, Anna H., Tseng, Chiu-Chen, Van Den Berg, David, Stram, Daniel O., Bogdanova, Natalia, Dörk, Thilo, Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Shu, Xiao-Ou, Lu, Wei, Gao, Yu-Tang, Zhang, Ben, Couch, Fergus J., Toland, Amanda E., Yannoukakos, Drakoulis, Sangrajrang, Suleeporn, McKay, James, Wang, Xianshu, Olson, Janet E., Vachon, Celine, Purrington, Kristen, Severi, Gianluca, Baglietto, Laura, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Le Marchand, Loic, Devilee, Peter, Tollenaar, Robert A.E.M., Seynaeve, Caroline, Czene, Kamila, Eriksson, Mikael, Humphreys, Keith, Darabi, Hatef, Ahmed, Shahana, Shah, Mitul, Pharoah, Paul D.P., Hall, Per, Giles, Graham G., Benítez, Javier, Dunning, Alison M., Chenevix-Trench, Georgia, Easton, Douglas F., Berchuck, Andrew, Eeles, Rosalind A., Olama, Ali Amin Al, Kote-Jarai, Zsofia, Benlloch, Sara, Antoniou, Antonis, McGuffog, Lesley, Offit, Ken, Lee, Andrew, Dicks, Ed, Luccarini, Craig, Tessier, Daniel C., Bacot, Francois, Vincent, Daniel, LaBoissière, Sylvie, Robidoux, Frederic, Nielsen, Sune F., Cunningham, Julie M., Windebank, Sharon A., Hilker, Christopher A., Meyer, Jeffrey, Angelakos, Maggie, Maskiell, Judi, Schoot, Ellen van der, Rutgers, Emiel, Verhoef, Senno, Hogervorst, Frans, Boonyawongviroj, Prat, Siriwanarungsan, Pornthep, Schrauder, Michael, Rübner, Matthias, Oeser, Sonja, Landrith, Silke, Williams, Eileen, Ryder-Mills, Elaine, Sargus, Kara, McInerney, Niall, Colleran, Gabrielle, Rowan, Andrew, Jones, Angela, Sohn, Christof, Schneewei, Andeas, Bugert, Peter, Álvarez, Núria, Lacey, James, Wang, Sophia, Ma, Huiyan, Lu, Yani, Deapen, Dennis, Pinder, Rich, Lee, Eunjung, Schumacher, Fred, Horn-Ross, Pam, Reynolds, Peggy, Nelson, David, Ziegler, Hartwig, Wolf, Sonja, Hermann, Volker, Lo, Wing-Yee, Justenhoven, Christina, Baisch, Christian, Fischer, Hans-Peter, Brüning, Thomas, Pesch, Beate, Rabstein, Sylvia, Lotz, Anne, Harth, Volker, Heikkinen, Tuomas, Erkkilä, Irja, Aaltonen, Kirsimari, Smitten, Karl von, Antonenkova, Natalia, Hillemanns, Peter, Christiansen, Hans, Myöhänen, Eija, Kemiläinen, Helena, Thorne, Heather, Niedermayr, Eveline, Bowtell, D, Chenevix-Trench, G, deFazio, A, Gertig, D, Green, A, Webb, P, Green, A., Parsons, P., Hayward, N., Webb, P., Whiteman, D., Fung, Annie, Yashiki, June, Peuteman, Gilian, Smeets, Dominiek, Brussel, Thomas Van, Corthouts, Kathleen, Obi, Nadia, Heinz, Judith, Behrens, Sabine, Eilber, Ursula, Celik, Muhabbet, Olchers, Til, Manoukian, Siranoush, Peissel, Bernard, Scuvera, Giulietta, Zaffaroni, Daniela, Bonanni, Bernardo, Feroce, Irene, Maniscalco, Angela, Rossi, Alessandra, Bernard, Loris, Tranchant, Martine, Valois, Marie-France, Turgeon, Annie, Heguy, Lea, Sze Yee, Phuah, Kang, Peter, Nee, Kang In, Mariapun, Shivaani, Sook-Yee, Yoon, Lee, Daphne, Ching, Teh Yew, Taib, Nur Aishah Mohd, Otsukka, Meeri, Mononen, Kari, Selander, Teresa, Weerasooriya, Nayana, staff, OFBCR, Krol-Warmerdam, E., Molenaar, J., Blom, J., Brinton, Louise, Szeszenia-Dabrowska, Neonila, Peplonska, Beata, Zatonski, Witold, Chao, Pei, Stagner, Michael, Bos, Petra, Blom, Jannet, Crepin, Ellen, Nieuwlaat, Anja, Heemskerk, Annette, Higham, Sue, Cross, Simon, Cramp, Helen, Connley, Dan, Balasubramanian, Sabapathy, Brock, Ian, Luccarini, Craig, Conroy, Don, Baynes, Caroline, and Chua, Kimberley

Published
2014
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322. Discovery and validation of methylation markers for endometrial cancer

Author

Wentzensen, Nicolas, Bakkum-Gamez, Jamie N., Killian, Keith J., Sampson, Joshua, Guido, Richard, Glass, Andrew, Adams, Lisa, Luhn, Patricia, Brinton, Louise A., Rush, Brenda, dʼAmbrosio, Lori, Gunja, Munira, Yang, Hannah P., Garcia-Closas, Montserrat, Lacey, James V., Jr., Lissowska, Jolanta, Podratz, Karl, Meltzer, Paul, Shridhar, Viji, and Sherman, Mark E.

Published
2014
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323. Consortium analysis of gene and gene–folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk

Author

Kelemen, Linda E., Terry, Kathryn L., Goodman, Marc T., Webb, Penelope M., Bandera, Elisa V., McGuire, Valerie, Rossing, Mary Anne, Wang, Qinggang, Dicks, Ed, Tyrer, Jonathan P., Song, Honglin, Kupryjanczyk, Jolanta, Dansonka-Mieszkowska, Agnieszka, Plisiecka-Halasa, Joanna, Timorek, Agnieszka, Menon, Usha, Gentry-Maharaj, Aleksandra, Gayther, Simon A., Ramus, Susan J., Narod, Steven A., Risch, Harvey A., McLaughlin, John R., Siddiqui, Nadeem, Glasspool, Rosalind, Paul, James, Carty, Karen, Gronwald, Jacek, Lubiński, Jan, Jakubowska, Anna, Cybulski, Cezary, Kiemeney, Lambertus A., Massuger, Leon F. A. G., van Altena, Anne M., Aben, Katja K. H., Olson, Sara H., Orlow, Irene, Cramer, Daniel W., Levine, Douglas A., Bisogna, Maria, Giles, Graham G., Southey, Melissa C., Bruinsma, Fiona, Kjær, Susanne K., Hgdall, Estrid, Jensen, Allan, Hgdall, Claus K., Lundvall, Lene, Engelholm, Svend-Aage, Heitz, Florian, du Bois, Andreas, Harter, Philipp, Schwaab, Ira, Butzow, Ralf, Nevanlinna, Heli, Pelttari, Liisa M., Leminen, Arto, Thompson, Pamela J., Lurie, Galina, Wilkens, Lynne R., Lambrechts, Diether, Van Nieuwenhuysen, Els, Lambrechts, Sandrina, Vergote, Ignace, Beesley, Jonathan, Fasching, Peter A., Beckmann, Matthias W., Hein, Alexander, Ekici, Arif B., Doherty, Jennifer A., Wu, Anna H., Pearce, Celeste L., Pike, Malcolm C., Stram, Daniel, Chang-Claude, Jenny, Rudolph, Anja, Dörk, Thilo, Dürst, Matthias, Hillemanns, Peter, Runnebaum, Ingo B., Bogdanova, Natalia, Antonenkova, Natalia, Odunsi, Kunle, Edwards, Robert P., Kelley, Joseph L., Modugno, Francesmary, Ness, Roberta B., Karlan, Beth Y., Walsh, Christine, Lester, Jenny, Orsulic, Sandra, Fridley, Brooke L., Vierkant, Robert A., Cunningham, Julie M., Wu, Xifeng, Lu, Karen, Liang, Dong, Hildebrandt, Michelle A.T., Weber, Rachel Palmieri, Iversen, Edwin S., Tworoger, Shelley S., Poole, Elizabeth M., Salvesen, Helga B., Krakstad, Camilla, Bjorge, Line, Tangen, Ingvild L., Pejovic, Tanja, Bean, Yukie, Kellar, Melissa, Wentzensen, Nicolas, Brinton, Louise A., Lissowska, Jolanta, Garcia-Closas, Montserrat, Campbell, Ian G., Eccles, Diana, Whittemore, Alice S., Sieh, Weiva, Rothstein, Joseph H., Anton-Culver, Hoda, Ziogas, Argyrios, Phelan, Catherine M., Moysich, Kirsten B., Goode, Ellen L., Schildkraut, Joellen M., Berchuck, Andrew, Pharoah, Paul D.P., Sellers, Thomas A., Brooks-Wilson, Angela, Cook, Linda S., and Le, Nhu D.

Published
2014
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324. Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia

Author

Setiawan, Veronica Wendy, Schumacher, Fredrick, Prescott, Jennifer, Haessler, Jeffrey, Malinowski, Jennifer, Wentzensen, Nicolas, Yang, Hannah, Chanock, Stephen, Brinton, Louise, Hartge, Patricia, Lissowska, Jolanta, Park, Lani S., Cheng, Iona, Bush, William S., Crawford, Dana C., Ursin, Giske, Horn-Ross, Pamela, Bernstein, Leslie, Lu, Lingeng, Risch, Harvey, Yu, Herbert, Sakoda, Lori C., Doherty, Jennifer, Chen, Chu, Jackson, Rebecca, Yasmeen, Shagufta, Cote, Michele, Kocarnik, Jonathan M., Peters, Ulrike, Kraft, Peter, De Vivo, Immaculata, Haiman, Christopher A., Kooperberg, Charles, and Le Marchand, Loic

Published
2014
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327. Endogenous Progestogens and Colorectal Cancer Risk among Postmenopausal Women

Author

Michels, Kara A., primary, Geczik, Ashley M., additional, Bauer, Doug C., additional, Brinton, Louise A., additional, Buist, Diana S.M., additional, Cauley, Jane A., additional, Dallal, Cher M., additional, Falk, Roni T., additional, Hue, Trisha F., additional, Lacey, James V., additional, LaCroix, Andrea Z., additional, Tice, Jeffrey A., additional, Xu, Xia, additional, and Trabert, Britton, additional

Published
2021
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331. Genome-wide association study identifies novel breast cancer susceptibility loci

Author

Easton, Douglas F., Pooley, Karen A., Dunning, Alison M., Pharoah, Paul D. P., Thompson, Deborah, Ballinger, Dennis G., Struewing, Jeffery P., Morrison, Jonathan, Field, Helen, Luben, Robert, Wareham, Nicholas, Ahmed, Shahana, Healey, Catherine S., Bowman, Richard, Meyer, Kerstin B., Haiman, Christopher A., Kolonel, Laurence K., Henderson, Brian E., Le Marchand, Loic, Brennan, Paul, Sangrajrang, Suleeporn, Gaborieau, Valerie, Odefrey, Fabrice, Shen, Chen-Yang, Wu, Pei-Ei, Wang, Hui-Chun, Eccles, Diana, Evans, D. Gareth, Peto, Julian, Fletcher, Olivia, Johnson, Nichola, Seal, Sheila, Stratton, Michael R., Rahman, Nazneen, Chenevix-Trench, Georgia, Bojesen, Stig E., Nordestgaard, Børge G., Axelsson, Christen K., Garcia-Closas, Montserrat, Brinton, Louise, Chanock, Stephen, Lissowska, Jolanta, Peplonska, Beata, Nevanlinna, Heli, Fagerholm, Rainer, Eerola, Hannaleena, Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Hunter, David J., Hankinson, Susan E., Cox, David G., Hall, Per, Wedren, Sara, Liu, Jianjun, Low, Yen-Ling, Bogdanova, Natalia, Schürmann, Peter, Dörk, Thilo, Tollenaar, Rob A. E. M., Jacobi, Catharina E., Devilee, Peter, Klijn, Jan G. M., Sigurdson, Alice J., Doody, Michele M., Alexander, Bruce H., Zhang, Jinghui, Cox, Angela, Brock, Ian W., MacPherson, Gordon, Reed, Malcolm W. R., Couch, Fergus J., Goode, Ellen L., Olson, Janet E., Meijers-Heijboer, Hanne, van den Ouweland, Ans, Uitterlinden, André, Rivadeneira, Fernando, Milne, Roger L., Ribas, Gloria, Gonzalez-Neira, Anna, Benitez, Javier, Hopper, John L., McCredie, Margaret, Southey, Melissa, Giles, Graham G., Schroen, Chris, Justenhoven, Christina, Brauch, Hiltrud, Hamann, Ute, Ko, Yon-Dschun, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, Mannermaa, Arto, Kosma, Veli-Matti, Kataja, Vesa, Hartikainen, Jaana, Day, Nicholas E., Cox, David R., and Ponder, Bruce A. J.

Published
2007
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334. Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE)

Author

Talhouk, Aline, George, Joshy, Wang, Chen, Budden, Timothy, Tan, Tuan Zea, Chiu, Derek S, Kommoss, Stefan, Leong, Huei San, Chen, Stephanie, Intermaggio, Maria P, Gilks, Blake, Nazeran, Tayyebeh M, Volchek, Mila, Elatre, Wafaa, Bentley, Rex C, Senz, Janine, Lum, Amy, Chow, Veronica, Sudderuddin, Hanwei, Mackenzie, Robertson, Leong, Samuel CY, Liu, Geyi, Johnson, Dustin, Chen, Billy, Group, Aocs, Alsop, Jennifer, Banerjee, Susana N, Behrens, Sabine, Bodelon, Clara, Brand, Alison H, Brinton, Louise, Carney, Michael E, Chiew, Yoke-Eng, Cushing-Haugen, Kara L, Cybulski, Cezary, Ennis, Darren, Fereday, Sian, Fortner, Renée T, García-Donas, Jesús, Gentry-Maharaj, Aleksandra, Glasspool, Rosalind, Goranova, Teodora, Greene, Casey S, Haluska, Paul, Harris, Holly R, Hendley, Joy, Hernandez, Brenda Y, Herpel, Esther, Jimenez-Linan, Mercedes, Karpinskyj, Chloe, Kaufmann, Scott H, Keeney, Gary L, Kennedy, Catherine J, Köbel, Martin, Koziak, Jennifer M, Larson, Melissa C, Lester, Jenny, Lewsley, Liz-Anne, Lissowska, Jolanta, Lubiński, Jan, Luk, Hugh, Macintyre, Geoff, Mahner, Sven, McNeish, Iain A, Menkiszak, Janusz, Nevins, Nikilyn, Osorio, Ana, Oszurek, Oleg, Palacios, José, Hinsley, Samantha, Pearce, Celeste L, Pike, Malcolm C, Piskorz, Anna M, Ray-Coquard, Isabelle, Rhenius, Valerie, Rodriguez-Antona, Cristina, Sharma, Raghwa, Sherman, Mark E, De Silva, Dilrini, Singh, Naveena, Sinn, Peter, Slamon, Dennis, Song, Honglin, Steed, Helen, Stronach, Euan A, Thompson, Pamela J, Tołoczko, Aleksandra, Trabert, Britton, Traficante, Nadia, Tseng, Chiu-Chen, Widschwendter, Martin, Wilkens, Lynne R, Winham, Stacey J, Winterhoff, Boris, Beeghly-Fadiel, Alicia, Benitez, Javier, Berchuck, Andrew, Brenton, James D, Brown, Robert, and Chang-Claude, Jenny

Subjects
Cystadenoma, Clinical Trials and Supportive Activities, Oncology and Carcinogenesis, Rare Diseases, Clinical Research, Genetics, Humans, Lymphocytes, Tumor-Infiltrating, Oncology & Carcinogenesis, Aged, Cancer, Ovarian Neoplasms, Neoplastic, screening and diagnosis, Serous, Middle Aged, Neoplasm Proteins, Ovarian Cancer, Detection, Good Health and Well Being, Gene Expression Regulation, Residual, Neoplasm, Female, Neoplasm Grading, Transcriptome, Algorithms, Biotechnology, 4.2 Evaluation of markers and technologies
Abstract

PurposeGene expression-based molecular subtypes of high-grade serous tubo-ovarian cancer (HGSOC), demonstrated across multiple studies, may provide improved stratification for molecularly targeted trials. However, evaluation of clinical utility has been hindered by nonstandardized methods, which are not applicable in a clinical setting. We sought to generate a clinical grade minimal gene set assay for classification of individual tumor specimens into HGSOC subtypes and confirm previously reported subtype-associated features.Experimental designAdopting two independent approaches, we derived and internally validated algorithms for subtype prediction using published gene expression data from 1,650 tumors. We applied resulting models to NanoString data on 3,829 HGSOCs from the Ovarian Tumor Tissue Analysis consortium. We further developed, confirmed, and validated a reduced, minimal gene set predictor, with methods suitable for a single-patient setting.ResultsGene expression data were used to derive the predictor of high-grade serous ovarian carcinoma molecular subtype (PrOTYPE) assay. We established a de facto standard as a consensus of two parallel approaches. PrOTYPE subtypes are significantly associated with age, stage, residual disease, tumor-infiltrating lymphocytes, and outcome. The locked-down clinical grade PrOTYPE test includes a model with 55 genes that predicted gene expression subtype with >95% accuracy that was maintained in all analytic and biological validations.ConclusionsWe validated the PrOTYPE assay following the Institute of Medicine guidelines for the development of omics-based tests. This fully defined and locked-down clinical grade assay will enable trial design with molecular subtype stratification and allow for objective assessment of the predictive value of HGSOC molecular subtypes in precision medicine applications.See related commentary by McMullen et al., p. 5271.

Published
2020

335. Additional file 3 of Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland

Author

Nyante, Sarah J, Faupel-Badger, Jessica M, Sherman, Mark E, Pfeiffer, Ruth M, Gaudet, Mia M, Falk, Roni T, Abegail A Andaya, Lissowska, Jolanta, Brinton, Louise A, Peplonska, Beata, Vonderhaar, Barbara K, Chanock, Stephen, Garcia-Closas, Montserrat, and Jonine D Figueroa

Subjects
Data_FILES
Abstract

Authors’ original file for figure 1

Published
2020
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336. Additional file 1 of Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland

Author

Nyante, Sarah J, Faupel-Badger, Jessica M, Sherman, Mark E, Pfeiffer, Ruth M, Gaudet, Mia M, Falk, Roni T, Abegail A Andaya, Lissowska, Jolanta, Brinton, Louise A, Peplonska, Beata, Vonderhaar, Barbara K, Chanock, Stephen, Garcia-Closas, Montserrat, and Jonine D Figueroa

Subjects
endocrine system, skin and connective tissue diseases, humanities, hormones, hormone substitutes, and hormone antagonists, eye diseases
Abstract

Additional file 1: Supplementary tables S1-S3. Supplementary table S1. PRLR haplotypes associated with postmenopausal breast cancer in the Polish Breast Cancer Study. Supplementary table S2. Association between PRLR and PRL SNPs and breast cancer risk in the Polish Breast Cancer Study. Supplementary table S3a. Association between PRLR and PRL SNPs and serum prolactin levels among premenopausal controls in the Polish Breast Cancer Study. Supplementary table S3b. Association between PRLR and PRL SNPs and serum prolactin levels among postmenopausal controls in the Polish Breast Cancer Study. (DOC 442 KB)

Published
2020
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337. Additional file 2 of Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland

Author

Nyante, Sarah J, Faupel-Badger, Jessica M, Sherman, Mark E, Pfeiffer, Ruth M, Gaudet, Mia M, Falk, Roni T, Abegail A Andaya, Lissowska, Jolanta, Brinton, Louise A, Peplonska, Beata, Vonderhaar, Barbara K, Chanock, Stephen, Garcia-Closas, Montserrat, and Jonine D Figueroa

Subjects
fungi
Abstract

Additional file 2: Supplementary figure S1. Log-prolactin distribution in postmenopausal controls, by rs849872 genotype. (PDF 75 KB)

Published
2020
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338. Additional file of Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland

Author

Nyante, Sarah J, Faupel-Badger, Jessica M, Sherman, Mark E, Pfeiffer, Ruth M, Gaudet, Mia M, Falk, Roni T, Abegail A Andaya, Lissowska, Jolanta, Brinton, Louise A, Peplonska, Beata, Vonderhaar, Barbara K, Chanock, Stephen, Garcia-Closas, Montserrat, and Jonine D Figueroa

Subjects
endocrine system, hormones, hormone substitutes, and hormone antagonists
Abstract

Additional file of Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland

Published
2020
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341. The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles : An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, V, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, V, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, V, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, V, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Wentzensen, Nicolas

Abstract

Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address this, analyses included individual-level data from 558,709 naturally menopausal women across 20 prospective cohorts, among whom 3,246 developed invasive epithelial ovarian cancer (2,045 serous, 319 endometrioid, 184 mucinous, 121 clear cell, 577 other/unknown). Cox models were used to estimate multivariable-adjusted HRs between lifetime ovulatory cycles (LOC) and its components and ovarian cancer risk overall and by histotype. Women in the 90th percentile of LOC (>514 cycles) were almost twice as likely to be diagnosed with ovarian cancer than women in the 10th percentile (<294) [HR (95% confidence interval): 1.92 (1.60-2.30)]. Risk increased 14% per 5-year increase in LOC (60 cycles) [(1.10-1.17)]; this association remained after adjustment for LOC components: number of pregnancies and oral contraceptive use [1.08 (1.04-1.12)]. The association varied by histotype, with increased risk of serous [1.13 (1.09-1.17)], endometrioid [1.20 (1.10-1.32)], and clear cell [1.37 (1.18-1.58)], but not mucinous [0.99 (0.88-1.10), P-heterogeneity = 0.01] tumors. Heterogeneity across histotypes was reduced [P-heterogeneity = 0.15] with adjustment for LOC components [1.08 serous, 1.11 endometrioid, 1.26 clear cell, 0.94 mucinous]. Although the 10-year absolute risk of ovarian cancer is small, it roughly doubles as the number of LOC rises from approximately 300 to 500. The consistency and linearity of effects strongly support the hypothesis that each ovulation leads to small increases in the risk of most ovarian cancers, a risk that cumulates through life, suggesting this as an important area for identifying intervention strategies.

Published
2020
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342. Cross-cancer genome-wide association study of endometrial cancer and epithelial ovarian cancer identifies genetic risk regions associated with risk of both cancers

Author

Glubb, Dylan M, Glubb, Dylan M, Thompson, Deborah J, Aben, Katja KH, Alsulimani, Ahmad, Amant, Frederic, Annibali, Daniela, Attia, John, Barricarte, Aurelio, Beckmann, Matthias W, Berchuck, Andrew, Bermisheva, Marina, Bernardini, Marcus Q, Bischof, Katharina, Bjorge, Line, Bodelon, Clara, Brand, Alison H, Brenton, James D, Brinton, Louise, Bruinsma, Fiona, Buchanan, Daniel D, Burghaus, Stefanie, Butzow, Ralf, Cai, Hui, Carney, Michael E, Chanock, Stephen J, Chen, Chu, Chen, Xiao Qing, Chen, Zhihua, Cook, Linda S, Cunningham, Julie M, De Vivo, Immaculata, deFazio, Anna, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dunning, Alison M, Dürst, Matthias, Edwards, Todd, Edwards, Robert P, Ekici, Arif B, Ewing, Ailith, Fasching, Peter A, Ferguson, Sarah, Flanagan, James M, Fostira, Florentia, Fountzilas, George, Friedenreich, Christine M, Gao, Bo, Gaudet, Mia M, Gawełko, Jan, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goodman, Marc T, Gronwald, Jacek, Group, OPAL Study, Group, AOCS, Harris, Holly R, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Høgdall, Estrid, Høgdall, Claus K, Holliday, Elizabeth G, Huntsman, David G, Huzarski, Tomasz, Jakubowska, Anna, Jensen, Allan, Jones, Michael E, Karlan, Beth Y, Karnezis, Anthony, Kelley, Joseph L, Khusnutdinova, Elza, Killeen, Jeffrey L, Kjaer, Susanne K, Klapdor, Rüdiger, Köbel, Martin, Konopka, Bozena, Konstantopoulou, Irene, Kopperud, Reidun K, Koti, Madhuri, Kraft, Peter, Kupryjanczyk, Jolanta, Lambrechts, Diether, Larson, Melissa C, Le Marchand, Loic, Lele, Shashikant B, Lester, Jenny, Li, Andrew J, Liang, Dong, Liebrich, Clemens, Lipworth, Loren, Lissowska, Jolanta, Lu, Lingeng, Lu, Karen H, Macciotta, Alessandra, Mattiello, Amalia, May, Taymaa, Glubb, Dylan M, Glubb, Dylan M, Thompson, Deborah J, Aben, Katja KH, Alsulimani, Ahmad, Amant, Frederic, Annibali, Daniela, Attia, John, Barricarte, Aurelio, Beckmann, Matthias W, Berchuck, Andrew, Bermisheva, Marina, Bernardini, Marcus Q, Bischof, Katharina, Bjorge, Line, Bodelon, Clara, Brand, Alison H, Brenton, James D, Brinton, Louise, Bruinsma, Fiona, Buchanan, Daniel D, Burghaus, Stefanie, Butzow, Ralf, Cai, Hui, Carney, Michael E, Chanock, Stephen J, Chen, Chu, Chen, Xiao Qing, Chen, Zhihua, Cook, Linda S, Cunningham, Julie M, De Vivo, Immaculata, deFazio, Anna, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dunning, Alison M, Dürst, Matthias, Edwards, Todd, Edwards, Robert P, Ekici, Arif B, Ewing, Ailith, Fasching, Peter A, Ferguson, Sarah, Flanagan, James M, Fostira, Florentia, Fountzilas, George, Friedenreich, Christine M, Gao, Bo, Gaudet, Mia M, Gawełko, Jan, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goodman, Marc T, Gronwald, Jacek, Group, OPAL Study, Group, AOCS, Harris, Holly R, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Høgdall, Estrid, Høgdall, Claus K, Holliday, Elizabeth G, Huntsman, David G, Huzarski, Tomasz, Jakubowska, Anna, Jensen, Allan, Jones, Michael E, Karlan, Beth Y, Karnezis, Anthony, Kelley, Joseph L, Khusnutdinova, Elza, Killeen, Jeffrey L, Kjaer, Susanne K, Klapdor, Rüdiger, Köbel, Martin, Konopka, Bozena, Konstantopoulou, Irene, Kopperud, Reidun K, Koti, Madhuri, Kraft, Peter, Kupryjanczyk, Jolanta, Lambrechts, Diether, Larson, Melissa C, Le Marchand, Loic, Lele, Shashikant B, Lester, Jenny, Li, Andrew J, Liang, Dong, Liebrich, Clemens, Lipworth, Loren, Lissowska, Jolanta, Lu, Lingeng, Lu, Karen H, Macciotta, Alessandra, Mattiello, Amalia, and May, Taymaa

Abstract

Accumulating evidence suggests a relationship between endometrial cancer and epithelial ovarian cancer. For example, endometrial cancer and epithelial ovarian cancer share epidemiological risk factors and molecular features observed across histotypes are held in common (e.g. serous, endometrioid and clear cell). Independent genome-wide association studies (GWAS) for endometrial cancer and epithelial ovarian cancer have identified 16 and 27 risk regions, respectively, four of which overlap between the two cancers. Using GWAS summary statistics, we explored the shared genetic etiology between endometrial cancer and epithelial ovarian cancer. Genetic correlation analysis using LD Score regression revealed significant genetic correlation between the two cancers (rG = 0.43, P = 2.66 × 10−5). To identify loci associated with the risk of both cancers, we implemented a pipeline of statistical genetic analyses (i.e. inverse-variance meta-analysis, co-localization, and M-values), and performed analyses by stratified by subtype. We found seven loci associated with risk for both cancers (PBonferroni < 2.4 × 10−9). In addition, four novel regions at 7p22.2, 7q22.1, 9p12 and 11q13.3 were identified at a sub-genome wide threshold (P < 5 × 10−7). Integration with promoter-associated HiChIP chromatin loops from immortalized endometrium and epithelial ovarian cell lines, and expression quantitative trait loci (eQTL) data highlighted candidate target genes for further investigation.

Published
2020

343. The risk of ovarian cancer increases with an increase in the lifetime number of ovulatory cycles: an analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Trabert, Britton, Tworoger, Shelley S, O'Brien, Katie M, Townsend, Mary K, Fortner, Renée T, Iversen, Edwin S, Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A, Bernstein, Leslie, Brinton, Louise A, Buring, Julie E, Dossus, Laure, Fraser, Gary E, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Harris, Holly R, Hoffman Bolton, Judith, Idahl, Annika, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Kvaskoff, Marina, Lacey, James V, Lee, I-Min, Milne, Roger L, Onland-Moret, N Charlotte, Overvad, Kim, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Riboli, Elio, Robien, Kim, Rohan, Thomas E, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Setiawan, Veronica Wendy, Swerdlow, Anthony J, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Visvanathan, Kala, Wilkens, Lynne R, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Trabert, Britton, Tworoger, Shelley S, O'Brien, Katie M, Townsend, Mary K, Fortner, Renée T, Iversen, Edwin S, Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A, Bernstein, Leslie, Brinton, Louise A, Buring, Julie E, Dossus, Laure, Fraser, Gary E, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Harris, Holly R, Hoffman Bolton, Judith, Idahl, Annika, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Kvaskoff, Marina, Lacey, James V, Lee, I-Min, Milne, Roger L, Onland-Moret, N Charlotte, Overvad, Kim, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Riboli, Elio, Robien, Kim, Rohan, Thomas E, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Setiawan, Veronica Wendy, Swerdlow, Anthony J, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Visvanathan, Kala, Wilkens, Lynne R, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Wentzensen, Nicolas

Published
2020

345. A debriefing session with a nutritionist can improve dietary assessment using food diaries

Author

Cantwell, Marie M., Millen, Amy E., Carroll, Raymond, Mittl, Beth L., Hermansen, Sigurd, Brinton, Louise A., and Potischman, Nancy

Subjects
Food exchange lists -- Usage, Food exchange lists -- Analysis, Women -- Health aspects, Women -- Research, Food/cooking/nutrition
Abstract

The objective of the current study was to evaluate the effect of a debriefing call on nutrient intake estimates using two 3-d food diaries among women participating in the Women's Health and Interview Study (WISH) Diet Validation Study. Subjects were 207 women with complete data and six 24-h recalls (24-HR) by telephone over 8 mo followed by two 3-d food diaries during the next 4 mo. Nutrient intake was assessed using the food diaries before and after a debriefing session by telephone. The purpose of the debriefing call was to obtain more detailed information on the types and amounts of fat in the diet. However, due to the ubiquitous nature of fat in the diet, the debriefing involved providing more specific detail on many aspects of the diet. There was a significant difference in macronutrient and micronutrient intake estimates after the debriefing. Estimates of protein, carbohydrate, and fiber intake were significantly higher and total fat, monounsaturated fat, saturated fat, vitamin A, vitamin C, [alpha]-tocopherol, folic acid, and calcium intake were significantly lower after the debriefing (P < 0.05). The limits of agreement between the food diaries before and after the debriefing were especially large for total fat intake, which could be under- or overestimated by ~15 g/d. The debriefing call improved attenuation coefficients associated with measurement error for vitamin C, folic acid, iron, [alpha] tocopherol, vitamin A, and calcium estimates. A hypothetical relative risk (RR) 2.0 could be attenuated to 1.16 for folic acid intake assessed without a debriefing but to only 1.61 with a debriefing. Depending on the nutrients of interest, the inclusion of a debriefing can reduce the potential attenuation of RR in studies evaluating diet disease associations. KEY WORDS: * food diaries * dietary assessment * attenuation

Published
2006

346. Associations of fecal microbial profiles with breast cancer and nonmalignant breast disease in the Ghana Breast Health Study

Author

Byrd, Doratha A., primary, Vogtmann, Emily, additional, Wu, Zeni, additional, Han, Yongli, additional, Wan, Yunhu, additional, Clegg‐Lamptey, Joe‐Nat, additional, Yarney, Joel, additional, Wiafe‐Addai, Beatrice, additional, Wiafe, Seth, additional, Awuah, Baffour, additional, Ansong, Daniel, additional, Nyarko, Kofi, additional, Hullings, Autumn G., additional, Hua, Xing, additional, Ahearn, Thomas, additional, Goedert, James J., additional, Shi, Jianxin, additional, Knight, Rob, additional, Figueroa, Jonine D., additional, Brinton, Louise A., additional, Garcia‐Closas, Montserrat, additional, and Sinha, Rashmi, additional

Published
2021
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347. Sex Hormones, Insulin, and Insulin-like Growth Factors in Recurrence of High-Stage Endometrial Cancer

Author

Merritt, Melissa A., primary, Strickler, Howard D., additional, Hutson, Alan D., additional, Einstein, Mark H., additional, Rohan, Thomas E., additional, Xue, Xiaonan, additional, Sherman, Mark E., additional, Brinton, Louise A., additional, Yu, Herbert, additional, Miller, David S., additional, Ramirez, Nilsa C., additional, Lankes, Heather A., additional, Birrer, Michael J., additional, Huang, Gloria S., additional, and Gunter, Marc J., additional

Published
2021
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348. Abstract PO029: Oral contraceptive use and postmenopausal sex steroid hormone metabolism

Author

Michels, Kara A., primary, Coburn, Sally B., additional, Anderson, Garnet, additional, Brinton, Louise A., additional, Chen, Chu, additional, Falk, Roni T., additional, Gass, Margery L., additional, Geczik, Ashley M., additional, Manson, JoAnn E., additional, Pfeiffer, Ruth M., additional, Reding, Kerryn, additional, Sarto, Gloria E., additional, Wentzensen, Nicolas, additional, Wild, Robert A., additional, Xu, Xia, additional, and Trabert, Britton, additional

Published
2021
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349. Breast Cancer Risk in Women from Ghana Carrying Rare Germline Pathogenic Mutations: A Resource for Genetic Counseling of West African Women

Author

Ahearn, Thomas U., primary, Choudhury, Parichoy Pal, additional, Derkach, Andriy, additional, Wiafe, Beatrice Addai, additional, Awuah, Baffour, additional, Yarney, Joel, additional, Edusei, Lawrence, additional, Titiloye, Nicholas, additional, Vanderpuye, Verna, additional, Aitpillah, Francis, additional, Dedey, Florence, additional, Oppong, Joseph, additional, Osei-Bonsu, Ernest, additional, Duggan, Máire, additional, Brinton, Louise A., additional, Luccarini, Craig, additional, Baynes, Caroline, additional, Dunning, Alison M., additional, Davis Lynn, Brittny C., additional, Chanock, Stephen, additional, Hicks, Belynda, additional, Yeager, Meredith, additional, Chatterjee, Nilanjan, additional, Biritwum, Richard, additional, Clegg-Lamptey, Joe Nat, additional, Nyarko, Kofi, additional, Wiafe, Seth, additional, Ansong, Daniel, additional, Easton, Douglas F., additional, Figueroa, Jonine, additional, Garcia-Closas, Montserrat, additional, and Study (GBHS), Ghana Breast Health, additional

Published
2021
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