145 results on '"Chen, Xiao‐Qin"'
Search Results
102. Overexpression and Small Molecule-Triggered Downregulation of CIP2A in Lung Cancer
- Author
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Ma, Liang, primary, Wen, Zhe-Sheng, additional, Liu, Zi, additional, Hu, Zheng, additional, Ma, Jun, additional, Chen, Xiao-Qin, additional, Liu, Yong-Qiang, additional, Pu, Jian-Xin, additional, Xiao, Wei-Lie, additional, Sun, Han-Dong, additional, and Zhou, Guang-Biao, additional
- Published
- 2011
- Full Text
- View/download PDF
103. The effect of prophylactic lamivudine on hepatitis B virus reactivation in HBsAg-positive patients with diffuse large B-cell lymphoma undergoing prolonged rituximab therapy
- Author
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Chen, Xiao-Qin, primary, Peng, Jie-Wen, additional, Lin, Gui-Nan, additional, Li, Mei, additional, and Xia, Zhong-Jun, additional
- Published
- 2011
- Full Text
- View/download PDF
104. Evaluating Plant-Available Potassium in Different Soils Using a Modified Sodium Tetraphenylboron Method
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Wang, Huo-Yan, primary, Sun, Hai-Xia, additional, Zhou, Jian-Min, additional, Cheng, Wei, additional, Du, Chang-Wen, additional, and Chen, Xiao-Qin, additional
- Published
- 2010
- Full Text
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105. Potassium Fractions in Soils as Affected by Monocalcium Phosphate, Ammonium Sulfate, and Potassium Chloride Application
- Author
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WANG, Huo-Yan, primary, ZHOU, Jian-Min, additional, DU, Chang-Wen, additional, and CHEN, Xiao-Qin, additional
- Published
- 2010
- Full Text
- View/download PDF
106. Study on the Effect of Lycium ruthenicum Murray Fruit Polysaccharide on the Athletic Ability of Mice and the Dose-effect
- Author
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FENG, Wei, primary, HE, En-peng, additional, and CHEN, Xiao-qin, additional
- Published
- 2010
- Full Text
- View/download PDF
107. Significance of serum levels of tumor necrosis factor-alpha and interleukin-6 in patients with nonalcoholic fatty liver disease
- Author
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Xie, Ling-Li, primary, Zhou, Li, additional, Li, Li-Bin, additional, Chen, Xiao-Qin, additional, Zhang, Yong-Hong, additional, and Yang, Jie, additional
- Published
- 2010
- Full Text
- View/download PDF
108. Phase II Trial of XELOX as First-Line Treatment for Patients with Advanced Gastric Cancer
- Author
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Luo, Hui-yan, primary, Xu, Rui-hua, additional, Wang, Feng, additional, Qiu, Miao-zhen, additional, Li, Yu-hong, additional, Li, Fang-hua, additional, Zhou, Zhi-wei, additional, and Chen, Xiao-qin, additional
- Published
- 2010
- Full Text
- View/download PDF
109. Detection of p16 and MGMT promoter methylation in gastric carcinomas by nested methylation-specific polymerase chain reaction
- Author
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Wang, Yan, primary, Zhou, Li, additional, Chen, Xiao-Qin, additional, Zhang, Wei, additional, and Wang, Lan, additional
- Published
- 2010
- Full Text
- View/download PDF
110. Synergy between Proteasome Inhibitors and Imatinib Mesylate in Chronic Myeloid Leukemia
- Author
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Hu, Zheng, primary, Pan, Xiao-Fen, additional, Wu, Fu-Qun, additional, Ma, Li-Yuan, additional, Liu, Da-Peng, additional, Liu, Ying, additional, Feng, Ting-Ting, additional, Meng, Fan-Yi, additional, Liu, Xiao-Li, additional, Jiang, Qian-Li, additional, Chen, Xiao-Qin, additional, Liu, Jing-Lei, additional, Liu, Ping, additional, Chen, Zhu, additional, Chen, Sai-Juan, additional, and Zhou, Guang-Biao, additional
- Published
- 2009
- Full Text
- View/download PDF
111. Impact of adjuvant chemotherapy duration on 3-year disease-free survival of colorectal carcinoma patients after radical resection
- Author
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Qiu, Miao-Zhen, primary, Teng, Kai-Yuan, additional, Ruan, Dan-Yun, additional, Li, Yu-Hong, additional, Chen, Xiao-Qin, additional, Pan, Zhi-Zhong, additional, He, You-Jian, additional, Wan, De-Sen, additional, and Xu, Rui-Hua, additional
- Published
- 2009
- Full Text
- View/download PDF
112. Changes in bone mineral density in patients with liver cirrhosis
- Author
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Fu, Lei, primary, Zhou, Li, additional, and Chen, Xiao-Qin, additional
- Published
- 2009
- Full Text
- View/download PDF
113. Effect of Nitrogen on the Degradation of Cypermethrin and Its Metabolite 3-Phenoxybenzoic Acid in Soil
- Author
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XIE, Wen-Jun, primary, ZHOU, Jian-Min, additional, WANG, Huo-Yan, additional, and CHEN, Xiao-Qin, additional
- Published
- 2008
- Full Text
- View/download PDF
114. Enhancement of Phosphorus Solubility by Humic Substances in Ferrosols
- Author
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HUA, Quan-Xian, primary, LI, Jian-Yun, additional, ZHOU, Jian-Min, additional, WANG, Huo-Yan, additional, DU, Chang-Wen, additional, and CHEN, Xiao-Qin, additional
- Published
- 2008
- Full Text
- View/download PDF
115. Effect of Long-Term Rice Straw Return on Soil Glomalin, Carbon and Nitrogen
- Author
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NIE, Jun, primary, ZHOU, Jian-Min, additional, WANG, Huo-Yan, additional, CHEN, Xiao-Qin, additional, and DU, Chang-Wen, additional
- Published
- 2007
- Full Text
- View/download PDF
116. Diastereo- and Enantioselective Synthesis of Chiral Pyrrolidine-Fused Spirooxindoles via Organocatalytic [3+2] 1,3-Dipolar Cycloaddition of Azomethine Ylides with Maleimides.
- Author
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Zhao, Hong ‐ Wu, Yang, Zhao, Meng, Wei, Tian, Ting, Li, Bo, Song, Xiu ‐ Qing, Chen, Xiao ‐ Qin, and Pang, Hai ‐ Liang
- Subjects
CINCHONA alkaloids ,CATALYST synthesis ,RING formation (Chemistry) ,SCHIFF bases ,ENANTIOSELECTIVE catalysis - Abstract
In the presence of a Cinchona alkaloid-based squaramide organocatalyst, the [3+2] cycloaddition of isatin-derived azomethine ylides with maleimides proceeded readily, thus delivering the desired pyrrolidine-fused spirooxindoles in 61-89% yields with >20:1 dr and 12 to >99 % ee. The absolute configuration of 5-chloro-1,5′-dimethyl-3′-phenyl-3′,3a′-dihydro-2′ H-spiro[indoline-3,1′-pyrrolo[3,4- c]pyrrole]-2,4′,6′(5′ H,6a′ H)-trione was unambiguously determined by means of X-ray single crystal structure analysis. The reaction mechanism was hypothesized to account for the enantioselective formation of 5-chloro-1,5′-dimethyl-3′-phenyl-3′,3a′-dihydro-2′ H-spiro[indoline-3,1′-pyrrolo[3,4- c]pyrrole]-2,4′,6′(5′ H,6a′ H)-trione. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
117. Hepatitis B virus infection correlates with poor prognosis of extranodal natural killer/T cell lymphoma.
- Author
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Wang, Liang, Wu-Xiao, Zhi-jun, Chen, Xiao-qin, Zhang, Yu-jing, Lu, Yue, and Xia, Zhong-jun
- Subjects
HEPATITIS B virus ,LYMPHOMAS ,VIRAL hepatitis ,CYTOTOXIC T cells ,ETIOLOGY of diseases - Abstract
Studies have shown that hepatitis B virus (HBV) infection may play an important role in the lymphomagenesis of lymphoma, but no studies regarding the relationship between HBV infection and extranodal natural killer/T cell lymphoma (ENKTL) have been reported previously. One hundred and seven patients diagnosed with ENKTL were retrospectively reviewed. The hepatitis B surface antigen (HBsAg)-positive rate was 13.1%, and no significant correlation existed between HBV infection and clinical characteristics (p > 0.05). No significant difference existed in complete remission rate between HBsAg-positive and -negative groups (42.9% vs. 44.1%, p = 1.000). In a multivariate Cox regression model that included international prognostic index (IPI) score, induction chemotherapy regimen and HBsAg status, all these variables were independent prognostic factors for overall survival (OS) and progression-free survival (PFS) (p < 0.05). In conclusion, the HBsAg-positive rate in ENKTL was similar to that of the normal population in a high HBV endemic area, and HBsAg-positive status was an independent prognostic factor for OS and PFS. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
118. A method of electric power system transient signals recognize based on similarity of wavelet time entropy matrixes
- Author
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HE, ZHENG-YOU, primary, CHEN, XIAO-QIN, additional, LUO, GUO-MIN, additional, and ZHAO, JING, additional
- Published
- 2006
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119. Physical and Psychomotor Development of 266 Children at 1-3 Years Conceived by ART.
- Author
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CHEN Xiao-qin, ZHANG Qing-xue, LI Yu, LIN Hai-yan, JIAO Xue-dan, YANG Dong-zi, LI Hong, and ZHAO Qian
- Subjects
- *
REPRODUCTIVE technology research , *CHILD development research , *COGNITIVE development research , *DEVELOPMENTAL psychology research , *REGRESSION analysis - Abstract
Objective: To investigate the physical and mental development of children of assisted reproductive techniques(ART) at 1-3 years, in the limited samples and the limited age range. Methods: A total of 266 ART children, including 106 twins, at 1-3 years were follow-up visited from February 2008 to February 2011. The control group comprised 129 children, including 84 twins, who were naturally bred. The neonatal outcomes, physical and mental development were evaluated. Results: Parent age in the ART children group was elder than that in control group. There were no significant differences in BMI, MDI and PDI between two groups of ART children and control, and between two twins' groups. A multivariate regression analysis indicated that the conception mode did not affect MDI and PDI. Conclusions: There are no significantly differences in the physical and psychomotor development between ART children and normal conception children in this study. [ABSTRACT FROM AUTHOR]
- Published
- 2014
120. Clinical Comparison of Behcet's Disease Between Japanese and Chinese Patients.
- Author
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WANG, Li-man, primary, MINESHITA, Satoru, additional, WANG, Jian-zhong, additional, DING, Su-xian, additional, LI, Wei-yun, additional, CHEN, Xiao-qin, additional, BIAN, Tian-yu, additional, JIANG, Xue-yi, additional, YANG, Gao-yun, additional, FENG, Gao-zhang, additional, LI, Lu-lu, additional, and MIYASHITA, Hideo, additional
- Published
- 1997
- Full Text
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121. Transformation of Human Breast Epithelial Cells by c‐Ha‐ras Oncogene
- Author
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Basolo, Fulvio, primary, Elliott, James, additional, Tait, Larry, additional, Chen, Xiao Qin, additional, Maloney, Terry, additional, Russo, Irma H., additional, Pauley, Robert, additional, Momiki, S., additional, Caamano, Jorge, additional, Klein‐Szanto, Andres J. P., additional, Koszalka, Maria, additional, and Russo, Jose, additional
- Published
- 1991
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122. Causes of death of advanced schistosomiasis patients in Jiaxing City from 1998 to 2008.
- Author
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Cai Chen-xiao, Xu Xiao-fei, and Chen Xiao-qin
- Published
- 2012
123. A follow-up study of first trimester induced abortions at hospitals and family planning clinics in Sichuan Province, China
- Author
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Luo, Lin, Wu, Shi-Zhong, Chen, Xiao-Qin, Li, Min-Xiang, and Pullum, Thomas W.
- Abstract
Four-thousand women aged 18–40 underwent an early induced abortion at hospitals and family planning clinics in six counties in Sichuan province, China, between 1 July 1990 and 30 June 1991. The subjects were followed-up three times, on days 15, 90 and 180 after the operation. Information was obtained about their age, parity, contraceptive use, social behaviors, and gynecological and psychological characteristics before and after the abortion. The results indicate that induced abortion is safe when provided by medically trained personnel in health facilities such as hospitals or clinics. Depressive symptomatology was assessed by the CES-D and SCL-90 scales. The depressive symptoms declined over time. A substantial proportion of the abortions were to unmarried women or resulted from non-use of contraception or contraceptive failure, implying that the incidence o f unintended pregnancies and induced abortions could be reduced by more effective and accessible contraception.
- Published
- 1996
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124. Chemotherapy of GEP Regimen(Gemcitabine,etoposide and Pegaspargase) for the Patients with Newly Diagnosed Extranodal Natural Killer/T Cell Lymphoma: a Phase II Clinical Trial
- Author
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Wang, Hua, Chen, Xiao-qin, Wang, Wei-da, and Xia, Zhong-jun
- Abstract
Introduction:Extranodal natural killer/T-cell lymphoma (ENKTL) is an aggressive form of non-Hodgkin's lymphoma,which is relatively more common in Asia and Latin America.Radiation therapy(RT) is widely administered for patients with localized nasal disease. However, local and systemic failures are observed frequently in patients who receive RT alone.Therefore, chemotherapy is needed in combination with RT to reduce the risk of recurrence. The patients with newly diagnosed stage III/IV ENKTL were rare and their prognosis was poorer.Chemotherapy was the major therapeutic tool for them.However,the optimal chemotherapy regimen for this disease has not been fully defined. Therefore, the purpose of this study is to prospectively evaluate efficacy and safety of GEP Regimen (Gemcitabine, Etopie and Pegaspargase ) in patients with newly diagnosed ENKTL(ClinicalTrials.gov number, NCT02705508).
- Published
- 2017
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- View/download PDF
125. Old Drugs with New Tricks: Rituximab in Combination with Albumin-Bound paclitaxel and Pegylated Liposomal Doxorubicin in the Treatment of Relapsed/Refractory Diffuse Large B Cell Lymphoma
- Author
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Wang, Liang, Wang, Hua, Chen, Xiao-qin, Wang, Wei-da, and Xia, Zhongjun
- Published
- 2017
- Full Text
- View/download PDF
126. ChemInform Abstract: Diastereoselective Synthesis of Dispirobarbiturates Through Et3N-Catalyzed [3 + 2] Cycloaddition of Barbiturate-Based Olefins with 3-Isothiocyanato Oxindoles.
- Author
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Zhao, Hong‐Wu, Tian, Ting, Li, Bo, Yang, Zhao, Pang, Hai‐Liang, Meng, Wei, Song, Xiu‐Qing, and Chen, Xiao‐Qin
- Published
- 2016
- Full Text
- View/download PDF
127. MK8617 inhibits M1 macrophage polarization and inflammation via the HIF-1α/GYS1/UDPG/P2Y 14 pathway.
- Author
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Qian L, Chen XQ, Kong D, Wang G, Cao Y, Xiao Y, Cao JY, and Zou C
- Subjects
- Humans, Lipopolysaccharides pharmacology, Hypoxia-Inducible Factor 1, alpha Subunit genetics, Inflammation chemically induced, Macrophages, Hypoxia metabolism, Uridine Diphosphate Glucose metabolism, Glycogen Synthase metabolism
- Abstract
Background: Nonresolving inflammation is a major driver of disease and needs to be taken seriously. Hypoxia-inducible factor (HIF) is closely associated with inflammation. Hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs), as stabilizers of HIF, have recently been reported to have the ability to block inflammation. We used MK8617, a novel HIF-PHI, to study its effect on macrophage inflammation and to explore its possible mechanisms., Methods: Cell viability after MK8617 and lipopolysaccharide (LPS) addition was assessed by Cell Counting Kit-8 (CCK8) to find the appropriate drug concentration. MK8617 pretreated or unpretreated cells were then stimulated with LPS to induce macrophage polarization and inflammation. Inflammatory indicators in cells were assessed by real-time quantitative reverse-transcription polymerase chain reaction (qRT-PCR), western blot (WB) and immunofluorescence (IF). The level of uridine diphosphate glucose (UDPG) in the cell supernatant was measured by ELISA. Purinergic G protein-coupled receptor P2Y
14 , as well as hypoxia-inducible factor-1α (HIF-1α) and glycogen synthase 1 (GYS1) were detected by qRT-PCR and WB. After UDPG inhibition with glycogen phosphorylase inhibitor (GPI) or knockdown of HIF-1α and GYS1 with lentivirus, P2Y14 and inflammatory indexes of macrophages were detected by qRT-PCR and WB., Results: MK8617 reduced LPS-induced release of pro-inflammatory factors as well as UDPG secretion and P2Y14 expression. UDPG upregulated P2Y14 and inflammatory indicators, while inhibition of UDPG suppressed LPS-induced inflammation. In addition, HIF-1α directly regulated GYS1, which encoded glycogen synthase, an enzyme that mediated the synthesis of glycogen by UDPG, thereby affecting UDPG secretion. Knockdown of HIF-1α and GYS1 disrupted the anti-inflammatory effect of MK8617., Conclusions: Our study demonstrated the role of MK8617 in macrophage inflammation and revealed that its mechanism of action may be related to the HIF-1α/GYS1/UDPG/P2Y14 pathway, providing new therapeutic ideas for the study of inflammation., Competing Interests: The authors declare that they have no competing interests., (© 2023 Qian et al.)- Published
- 2023
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128. [3 + 2] Cycloaddition of Oxazol-5-(4H)-ones with Nitrones for Diastereoselective Synthesis of Isoxazolidin-5-ones.
- Author
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Zhao HW, Liu YY, Zhao YD, Pang HL, Chen XQ, Song XQ, Tian T, Li B, Yang Z, Du J, and Feng NN
- Abstract
In the presence of TMSCl, the [3 + 2] cycloaddition of oxazol-5-(4H)-ones with nitrones proceeded smoothly and furnished the desired isoxazolidin-5-ones with high diastereoselectivities in reasonable chemical yields. The chemical structure of the title compounds was firmly confirmed by X-ray single-crystal structure analysis.
- Published
- 2017
- Full Text
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129. [Moxibustion at Yongquan (KI 1) for sleep disorders of chronic fatigue syndrome].
- Author
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Chen XQ, Gang ZX, and Xu ZP
- Subjects
- Acupuncture Points, Adult, Fatigue Syndrome, Chronic complications, Female, Humans, Male, Middle Aged, Sleep Wake Disorders complications, Young Adult, Fatigue Syndrome, Chronic therapy, Moxibustion, Sleep Wake Disorders therapy
- Published
- 2013
130. [Evaluation of nutrient release profiles from polymer coated fertilizers using Fourier transform mid-infrared photoacoustic spectroscopy].
- Author
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Shen YZ, Du CW, Zhou JM, Wang HY, and Chen XQ
- Subjects
- Acrylates, Fourier Analysis, Nitrogen, Phosphorus, Polymers, Spectrophotometry, Infrared, Spectrum Analysis, Fertilizers, Spectroscopy, Fourier Transform Infrared
- Abstract
The acrylate-like materials were used to develop the polymer coated controlled release fertilizer, the nutrients release profiles were determined, meanwhile the Fourier transform mid-infrared photoacoustic spectra of the coatings were recorded and characterized; GRNN model was used to predict the nutrients release profiles using the principal components of the mid-infrared photoacoustic spectra as input. Results showed that the GRNN model could fast and effectively predict the nutrient release profiles, and the predicted calibration coefficients were more than 0.93; on the whole, the prediction errors (RMSE) were influenced by the profiling depth of the spectra, the average prediction error was 10.28%, and the spectra from the surface depth resulted in a lowest prediction error with 7.14%. Therefore, coupled with GRNN modeling, Fourier transform mid-infrared photoacoustic spectroscopy can be used as an alternative new technique in the fast and accurate prediction of nutrient release from polymer coated fertilizer.
- Published
- 2012
131. [Acupuncture and moxibustion for peripheral facial palsy at different stages: multi-central large-sample randomized controlled trial].
- Author
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Li Y, Li Y, Liu LA, Zhao L, Hu KM, Wu X, Chen XQ, Li GP, Mang LL, and Qi QH
- Subjects
- Adolescent, Adult, Aged, Combined Modality Therapy, Disease Progression, Facial Paralysis pathology, Female, Humans, Male, Middle Aged, Treatment Outcome, Young Adult, Acupuncture Therapy, Facial Paralysis therapy, Moxibustion
- Abstract
Objective: To explore the best intervention time of acupuncture and moxibustion for peripheral facial palsy (Bell's palsy) and the clinical advantage program of selective treatment with acupuncture and moxibustion., Methods: Multi-central large-sample randomized controlled trial was carried out. Nine hundreds cases of Bell's palsy were randomized into 5 treatment groups, named selective filiform needle group (group A), selective acupuncture + moxibustion group (group B), selective acupuncture + electroacupuncture (group C), selective acupuncture + line-up needling on muscle region of meridian group (group D) and non-selective filiform needle group (group E). Four sessions of treatment were required in each group. Separately, during the enrollment, after 4 sessions of treatment, in 1 month and 3 months of follow-up after treatment, House-Brackmann Scale, Facial Disability Index Scale and Degree of Facial Nerve Paralysis (NFNP) were adopted for efficacy assessment. And the efficacy systematic analysis was provided in view of the intervention time and nerve localization of disease separately., Results: The curative rates of intervention in acute stage and resting stage were 50.1% (223/445) and 52.1% (162/311), which were superior to recovery stage (25.9%, 35/135) separately. There were no statistical significant differences in efficacy in comparison among 5 treatment programs at the same stage (all P > 0.05). The efficacy of intervention of group A and group E in acute stage was superior to that in recovery stage (both P < 0.01). The difference was significant statistically between the efficacy on the localization above chorda tympani nerve and that on the localization below the nerve in group D (P < 0.01). The efficacy on the localization below chorda tympani nerve was superior to the localization above the nerve., Conclusion: The best intervention time for the treatment of Bell's palsy is in acute stage and resting stage, meaning 1 to 3 weeks after occurrence. All of the 5 treatment programs are advantageous to Bell's palsy. In the condition of the limited medical sources, the simple filiform needle therapy is recommended in acute stage. For the patients with the disorder above chorda tympani nerve, the line-up needling on muscle region of meridian is not recommended.
- Published
- 2011
132. Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines.
- Author
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Luo HY, Wei W, Shi YX, Chen XQ, Li YH, Wang F, Qiu MZ, Li FH, Yan SL, Zeng MS, Huang P, and Xu RH
- Subjects
- Antibodies, Monoclonal administration & dosage, Antibodies, Monoclonal, Humanized, Blotting, Western, Cell Line, Tumor, Cetuximab, Drug Interactions, Drug Synergism, Enzyme-Linked Immunosorbent Assay, ErbB Receptors metabolism, Humans, Hypoxia, Hypoxia-Inducible Factor 1, alpha Subunit metabolism, Mitogen-Activated Protein Kinase 1 metabolism, Mitogen-Activated Protein Kinase 3 metabolism, Organoplatinum Compounds administration & dosage, Oxaliplatin, Phosphatidylinositol 3-Kinases metabolism, Proto-Oncogene Proteins c-akt metabolism, Stomach Neoplasms metabolism, Stomach Neoplasms pathology, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Apoptosis drug effects, Cell Proliferation drug effects, Stomach Neoplasms drug therapy
- Abstract
Hypoxia is recognized as an important factor contributing to cancer development and drug resistance. Cetuximab, a chimeric monoclonal antibody to EGFR, is known to inhibit HIF-1 alpha expression levels and to enhance the cytotoxicity of chemotherapeutic agents. We demonstrated that hypoxia induced drug resistance in gastric cancer cells. Cetuximab enhanced oxaliplatin-induced cytotoxicity and apoptosis in normoxia and caused a reversal of drug resistance in hypoxia. Normoxic and hypoxic gastric cancer cells were treated with cetuximab, oxaliplatin or the combination and assessed for cell growth, proliferation, and apoptosis. Combination treatment resulted in a marked inhibition of HIF-1 alpha expression levels in hypoxic cells and caused a significant reduction in the expression of activated phosphorylated AKT, ERK1/2, p-BAD and VEGF in both normoxia and hypoxia with greater levels of inhibition in hypoxia. In summary, cetuximab inhibits HIF-1 alpha expression via the MAPK/ERK and PI3K/AKT signaling pathways and functions to overcome drug resistance induced by hypoxia. Cetuximab-oxaliplatin combination therapy may therefore emerge as an attractive treatment strategy for advanced gastric cancer.
- Published
- 2010
- Full Text
- View/download PDF
133. [Impact of adjuvant chemotherapy duration on 3-year disease-free survival of colorectal carcinoma patients after radical resection].
- Author
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Qiu MZ, Teng KY, Ruan DY, Li YH, Chen XQ, Pan ZZ, He YJ, Wan DS, and Xu RH
- Subjects
- Adenocarcinoma pathology, Adenocarcinoma surgery, Adenocarcinoma, Mucinous drug therapy, Adenocarcinoma, Mucinous pathology, Adenocarcinoma, Mucinous surgery, Adult, Age Factors, Aged, Capecitabine, Carcinoma, Signet Ring Cell drug therapy, Carcinoma, Signet Ring Cell pathology, Carcinoma, Signet Ring Cell surgery, Chemotherapy, Adjuvant, Colorectal Neoplasms pathology, Colorectal Neoplasms surgery, Deoxycytidine administration & dosage, Deoxycytidine analogs & derivatives, Disease-Free Survival, Female, Fluorouracil administration & dosage, Fluorouracil analogs & derivatives, Follow-Up Studies, Humans, Leucovorin administration & dosage, Lymphatic Metastasis, Male, Middle Aged, Multivariate Analysis, Neoplasm Staging, Organoplatinum Compounds administration & dosage, Oxaliplatin, Sex Factors, Tegafur administration & dosage, Adenocarcinoma drug therapy, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Colorectal Neoplasms drug therapy
- Abstract
Background and Objective: Adjuvant chemotherapy has become a standard postoperative treatment for stage III and high risk stage II colorectal carcinoma patients. However, only a few patients can finish 6-month adjuvant chemotherapy. This study was to find out whether the duration of adjuvant chemotherapy would affect the 3-year disease-free survival., Methods: Clinical data of 276 colorectal carcinoma patients, receiving at least two cycles of adjuvant chemotherapy including xeloda, 5-fluorouracil/calcium folinate (5-FU/CF) or Tegafur with or without oxaliplatin after radical operation in Sun Yat-sen University Cancer Center from April, 2003 to December, 2007, were analyzed for the impact of adjuvant chemotherapy duration on the 3-year disease-free survival., Results: Of the 276 patients, 216 received chemotherapy including oxaliplatin, 60 received xeloda, 5-FU/CF or tegafur as adjuvant chemotherapy. Of the 216 patients, only 49 finished the 6-month adjuvant chemotherapy. Both univariate and multivariate analyses showed that chemotherapy duration (P=0.032), sex (P=0.001), N stage (P=0.002), and pathologic differentiation (P=0.043) were independent prognosis factors for 3-year disease-free survival., Conclusion: Duration of adjuvant chemotherapy is an independent prognosis factor for 3-year disease-free survival of colorectal carcinoma patients.
- Published
- 2009
- Full Text
- View/download PDF
134. [Prognosis of 84 intrahepatic cholangiocarcinoma patients].
- Author
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Li FH, Chen XQ, Luo HY, Li YH, Wang F, Qiu MZ, Teng KY, Li ZH, and Xu RH
- Subjects
- Adult, Aged, Bile Duct Neoplasms blood, Bile Duct Neoplasms pathology, Bile Duct Neoplasms surgery, Bilirubin blood, CA-19-9 Antigen blood, Carcinoembryonic Antigen blood, Chemotherapy, Adjuvant, Cholangiocarcinoma blood, Cholangiocarcinoma pathology, Cholangiocarcinoma surgery, Female, Follow-Up Studies, Humans, Liver Neoplasms blood, Liver Neoplasms pathology, Liver Neoplasms surgery, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Staging, Neoplastic Cells, Circulating, Palliative Care, Proportional Hazards Models, Radiotherapy, Adjuvant, Remission Induction, Retrospective Studies, Survival Rate, Young Adult, Bile Ducts, Intrahepatic pathology, Bile Ducts, Intrahepatic surgery, Hepatectomy methods
- Abstract
Background and Objective: The incidence of intrahepatic cholangiocarcinoma (ICC) is low. Current treatment for ICC is unsatisfied. This study was to investigate the prognosis of patients with resectable or unresectable ICC., Methods: Clinical data of 84 patients with pathologically confirmed ICC treated at Cancer Center, Sun Yat-sen University from January 1997 to December 2007 were reviewed. Survival and prognosis were analyzed by Kaplan-Meier method and Cox regression model., Results: Of the 84 patients, 56 (66.7%) had resectable ICC, and 28 (33.3%) had unresectable ICC. Among the 56 patients with resectable ICC, 27 (48.2%) underwent radical resection, and 29 (51.8%) underwent palliative resection. The 2-year overall survival rate was 3.1% in unresectable ICC group; it was significantly higher in radical resection group than in palliative resection group (P<0.01). For the patients with resectable ICC, univariate analysis revealed that operation pattern, histological type, tumor size and number, lymph node metastasis, intrahepatic metastasis, portal vein thrombus, postoperative serum level of albumin, preoperative serum levels of CEA, CA199, TBIL, ALT and AST were related to the prognosis; multivariate analysis found that operation pattern, histological type, tumor number, preoperative serum levels of CEA, CA199 and TBIL were independent prognostic factors. For the patients with unresectable ICC, univariate analysis found that histological type and preoperative serum level of CA199 were related to the prognosis; whereas multivariate analysis found that histological type was the only independent prognostic factor. Chemotherapy showed no survival benefit in both resectable and unresectable ICC groups (P=0.30, P=0.78)., Conclusions: Radical resection is the main effective treatment for ICC patients to achieve long-term survival. Preoperative serum levels of CEA, CA199 and TBIL are significant prognostic factor for patients with resectable ICC.
- Published
- 2009
135. [Research advances in expression and functions of erythropoietin and erythropoietin receptor in cancers].
- Author
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Li M, Lu Y, and Chen XQ
- Subjects
- Anemia drug therapy, Erythropoietin analysis, Erythropoietin therapeutic use, Humans, Neoplasms complications, Receptors, Erythropoietin analysis, Recombinant Proteins, Erythropoietin physiology, Neoplasms metabolism, Receptors, Erythropoietin physiology
- Abstract
Erythropoietin (EPO) has firstly known to regulate cell proliferation and differentiation along the erythroid lineage. Recent studies have shown that EPO, a pleiotropic cytokine, is proangiogenic and exerts broad tissue-protective effects in diverse nonhematopoietic organs. A series of studies have documented the expression of EPO and EPO receptor (EPO-R) in various cancer cells. The presence of an autocrine-paracrine EPO/EPO-R system may associate with the potential for stimulation of tumor neoangiogenesis and tumor proliferation, inhibition of apoptosis, or modulation of sensitivity to chemoradiotherapy. The complex mechanism needs further research. Recombinant human erythropoietin (rh-EPO) has been widely used in clinic to treat malignancy-associated anemia. Clinical trials have documented the efficacy of rh-EPO in increasing hemoglobin levels, reducing red blood cell (RBC) transfusion requirements and improving quality of life in cancer patients. However, three randomized trials reported negative outcomes with rh-EPO, as patients in the rh-EPO arm fared worse than their placebo-treated counterparts with progression-free survival. This review described EPO and EPO-R biology, focusing on the expression, pleiotropic function and mechanism on nonhematopoietic tissues especially on cancer cells.
- Published
- 2008
136. [Regulating human interferon-gamma gene expression in marrow stromal cells in mice by Tet-off system].
- Author
-
Qin XT, Lu Y, Tan YD, Chen XQ, and Gen QR
- Subjects
- Animals, Bone Marrow Cells cytology, Cells, Cultured, Female, Gene Expression Regulation, Humans, Interferon-gamma genetics, Male, Mice, Mice, Inbred BALB C, Mice, Nude, Plasmids, RNA, Messenger metabolism, Spleen metabolism, Stromal Cells cytology, Transfection, Bone Marrow Cells metabolism, Interferon-gamma biosynthesis, Stromal Cells metabolism, Tetracycline pharmacology
- Abstract
Background & Objective: We have constructed plasmid "pTre-IFN-gamma" and proved that the Tet-off system could regulate the expression of human interferon-gamma (IFN-gamma) gene in murine marrow stromal cells in vitro. This study was to investigate the regulatory reversibility of Tet-off system and its effect on the expression of human IFN-gamma gene in murine marrow stromal cells in mice., Methods: Plasmids pTet-off and pTre-IFN-gamma were co-transfected into murine marrow stromal cells. The expression of IFN-gamma in marrow stromal cells was detected with ELISA. The marrow stromal cells were transfused into BABL/c naked mice after co-transfection. The expression of IFN-gamma mRNA in the spleen was detected by real-time fluorescent quantitative reverse transcription-polymerase chain reaction (RT-PCR)., Results: IFN-gamma protein was detected in the culture solution of marrow stromal cells after co-transfection. The secretion peak appeared within the first 72 h. The protein level of IFN-gamma was significantly lower in 300 ng/ml tetracycline hydrochloride-treated marrow stroma cells than in untreated cells [(67.11+/-22.14) pg/1 x 10(7) cells vs. (319.96+/-29.04) pg/1 x 10(7) cells, P<0.001]; its expression was increased when removed tetracycline hydrochloride (P=0.032). The expression of human IFN-gamma mRNA was detected in the spleen. The mRNA level of IFN-gamma was significantly higher in untreated group than in continuous tetracycline hydrochloride-treated group [(1.5+/-0.7)x10(5) copies . (100 mg)(-1) vs. (6.9+/-5.3)x10(2) copies . (100 mg)(-1), P<0.001]; its expression in the mice received tetracycline hydrochloride for one single time lay between the above two groups with significant difference., Conclusion: In mice, Tet-off system could rapidly, efficiently and reversibly regulate the expression of human IFN-gamma gene in marrow stromal cells in vitro and in vivo.
- Published
- 2008
137. [Expression of erythropoietin receptor in esophageal carcinoma and its correlation to microvessel density].
- Author
-
Li M, Lu Y, and Chen XQ
- Subjects
- Age Factors, Carcinoma, Squamous Cell blood supply, Carcinoma, Squamous Cell pathology, Esophageal Neoplasms blood supply, Esophageal Neoplasms pathology, Female, Humans, Immunohistochemistry, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Staging, Neovascularization, Pathologic pathology, Sex Factors, Smoking, von Willebrand Factor metabolism, Carcinoma, Squamous Cell metabolism, Esophageal Neoplasms metabolism, Microvessels pathology, Neovascularization, Pathologic metabolism, Receptors, Erythropoietin metabolism
- Abstract
Background & Objective: Erythropoietin receptor (EPO-R) is expressed in many kinds of tumors. The EPO/EPO-R signaling is involved in tumor cell proliferation, angiogenesis, and invasion. This study was to detect the expression of EPO-R in esophageal carcinoma, and explore its correlation to angiogenesis., Methods: The expression of EPO-R protein in 110 specimens of primary esophageal carcinoma was assessed by immunohistochemistry. The microvessels were immunohistochemically labeled with factor VIII-related antigen (FVIII-R Ag) to assess microvessel density (MVD)., Results: EPO-R was detected in all tumor tissues. It was expressed in cytoplasm and/or on cell membrane. Up-regulated EPO-R expression was correlated to poor differentiation (P<0.001) and lymph node metastasis (P=0.006). Increased MVD was correlated to poor differentiation (P<0.001), lymph node metastasis (P<0.001), advanced stage (III/IVA/IVB) (P=0.022), and smoking (P=0.029). The expression of EPO-R was positively correlated to MVD (r=0.618, P<0.01)., Conclusions: EPO-R expressed generally in esophageal carcinoma. The level of EPO-R positively correlates to angiogenesis and progression of esophageal carcinoma. EPO might be an endogenous stimulant of angiogenesis during the progression of esophageal carcinoma.
- Published
- 2008
138. [Efficacy of modified B-NHL-BFM-90 protocol on Burkitt's lymphoma in Chinese children and adolescents].
- Author
-
Sun XF, Zhen ZJ, Liu DG, Xia Y, Xiang XJ, Chen XQ, Ling JY, Zheng L, Luo WB, Lin H, He YJ, and Guan ZZ
- Subjects
- Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols adverse effects, Burkitt Lymphoma blood, Burkitt Lymphoma pathology, Child, Child, Preschool, Cyclophosphamide administration & dosage, Dexamethasone administration & dosage, Female, Follow-Up Studies, Humans, Ifosfamide administration & dosage, Infant, L-Lactate Dehydrogenase blood, Leukopenia chemically induced, Lymphatic Metastasis, Male, Neoplasm Invasiveness, Neoplasm Staging, Remission Induction, Vincristine administration & dosage, Young Adult, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Burkitt Lymphoma drug therapy
- Abstract
Background & Objective: Burkitt's lymphoma is an aggressive non-Hodgkin's lymphoma (NHL) and often involves bone marrow and central nerve system. The efficacy of CHOP regimen on Burkitt's lymphoma is poor. The optimal chemotherapy regimen needs to be investigated. This study was to evaluate the efficacy of modified B-NHL-BFM-90 protocol on Burkitt's lymphoma in children and adolescents, and observe the survival status., Methods: From Oct. 1999 to Nov. 2006, 31 untreated Burkitt's lymphoma patients aged less than 20 were enrolled. The median age of these patients was 5 (range, 1.5-20 years old). Of the 31 patients, 20 (64.5%) were male, 11 (35.5%) were female. According to St Jude staging system, 1 (3.2%) was at stage I, 6 (19.4%) at stage II, 8 (25.8%) at stage III, 16 (51.6%) at stage IV; 24 (77.4%) were at stage III/IV. According to clinical stage, lactate dehydrogenase (LDH) level and treatment response, these patients were divided into low, moderate and high risk groups. They received modified B-NHL-BFM-90 protocol: cytotoxic drugs such as cyclophosphamide, vincristine, ifosfamide, etoposide, adriamycin, HD-methotrexate, vindesin, dexamethasone, cytarabinec/HD-cytarabine and intrathecal injection., Results: One patient died of tumor lysis syndrome during prophase. The efficacy was evaluable in 30 patients. Of the 30 patients, 25 (83.3%) achieved complete remission (CR), 3 (10.0%) achieved partial remission (PR), 2 (6.7%) had progressive disease (PD)û 1 had tumor relapse. Grade 3-4 myelosuppression occurred in most patients and were recovered by active support care and did not affect next course of chemotherapy. At a median follow-up of 33 months (range, 3-98 months), the 3-year event-free survival (EFS) rate was 86.0% for all patients, with 100% for stage I/II patients and 82.1% for stage III/IV patients, 100% for low risk group, 92.0% for moderate risk group, and 70.0% for high risk group., Conclusions: Modified B-NHL-BFM-90 protocol can improve the responses and survival of Burkitt's lymphoma in Chinese children and adolescents, with tolerable toxicity. It should be used in the experienced cancer center and hematological unit.
- Published
- 2007
139. [Efficacy of gefitinib on advanced non-small cell lung cancer of bilateral diffuse or unilateral giant mass type].
- Author
-
Wen ZS, Chen XQ, Wu HY, Wei WD, and Rong TH
- Subjects
- Adenocarcinoma drug therapy, Adenocarcinoma pathology, Adult, Aged, Antineoplastic Agents adverse effects, Bone Neoplasms drug therapy, Bone Neoplasms secondary, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Squamous Cell drug therapy, Carcinoma, Squamous Cell pathology, Diarrhea chemically induced, Disease-Free Survival, Exanthema chemically induced, Female, Follow-Up Studies, Gefitinib, Humans, Lung Neoplasms pathology, Male, Middle Aged, Neoplasm Staging, Pruritus chemically induced, Quality of Life, Quinazolines adverse effects, Remission Induction, Antineoplastic Agents therapeutic use, Carcinoma, Non-Small-Cell Lung drug therapy, Lung Neoplasms drug therapy, Quinazolines therapeutic use
- Abstract
Background & Objective: No more survival improvement could be obtained in advanced non-small cell lung cancer (NSCLC) today with chemotherapy or radiotherapy. Clinical trails showed the antitumor effect of gefitinib on NSCLC with individual differences. This study was to select NSCLC patients of suitable type by comparing the efficacy of gefitinib on advanced NSCLC of bilateral diffuse type and unilateral giant mass type., Methods: Fifty advanced NSCLC patients of bilateral diffuse type (20 cases) and unilateral mass type (30 cases) received treatment of gefitinib. The efficacy of gefitinib on advanced NSCLC between the 2 groups was compared., Results: The median time to symptom improvement was significantly shorter in bilateral diffuse group than in unilateral mass group (4 days vs. 7 days, P<0.01). The disease control rate was significantly higher in bilateral diffuse group than in unilateral mass group (75% vs. 20%, P<0.01). The median progression-free time was significantly longer in bilateral diffuse group than in unilateral mass group (9.5 months vs. 3.6 months, P<0.01). Drug-related adverse events were similar in the 2 groups., Conclusions: Gefitinib is more effective to bilateral diffuse type NSCLC than to unilateral giant mass type NSCLC. It can be considered as the second-line medicine for bilateral diffuse type NSCLC.
- Published
- 2007
140. [Correlation of hepatitis B virus infection to non-Hodgkin's lymphoma].
- Author
-
Qin XT, Lu Y, Chen XQ, Xu HP, and Fan HJ
- Subjects
- Adolescent, Adult, Age Factors, Confidence Intervals, Female, Hepatitis B immunology, Humans, Lymphoma, B-Cell immunology, Lymphoma, B-Cell virology, Lymphoma, Non-Hodgkin immunology, Lymphoma, T-Cell immunology, Lymphoma, T-Cell virology, Male, Odds Ratio, Sex Factors, Young Adult, Colorectal Neoplasms virology, Hepatitis B Surface Antigens blood, Lymphoma, Non-Hodgkin virology
- Abstract
Background & Objective: Previous studies showed that the infection rate of hepatitis B virus (HBV) is higher in non-Hodgkin's lymphoma (NHL) patients than in non-primary liver cancer solid tumor patients and general population in the same region, but the correlation of HBV infection to NHL is inconclusive. This study was to compare HBV infection rate of NHL patients with that of non-primary liver cancer solid tumor patients, and explore the correlation of HBV infection to NHL., Methods: The infection of hepatitis B virus surface antigen (HBsAg) in 109 NHL patients and 128 colorectal carcinoma patients was detected. The positive rates of HBsAg in the patients and general population were compared by Chi-square test., Results: The positive rate of HBsAg was significantly higher in NHL patients than in colorectal carcinoma patients and general population (40.4% vs. 14.1% and 17.3%, P<0.01). Regarding colorectal carcinoma patients as a reference group, odds ratio (OR) of NHL in HbsAg-positive population was 2.87, and the 95% confidence interval (95% CI) was 1.830-4.502., Conclusion: The positive rate of HBsAg is higher in NHL patients than in colorectal carcinoma patients and general population.
- Published
- 2007
141. [Regulatory expression of human interferon-gamma gene in murine bone marrow stromal cells by Tet-off system].
- Author
-
Tan YD, Lu Y, Xu HP, Chen XQ, and Li XQ
- Subjects
- Animals, Bone Marrow Cells cytology, Cells, Cultured, Gene Expression Regulation, Interferon-gamma genetics, Mice, Mice, Inbred BALB C, Plasmids, RNA, Messenger metabolism, Stromal Cells cytology, Tetracycline administration & dosage, Transfection, Bone Marrow Cells metabolism, Interferon-gamma biosynthesis, Stromal Cells metabolism, Tetracycline pharmacology
- Abstract
Background & Objective: The Tet-off system is a gene expression regulating system, which has high efficiency, low toxicity and strict turning-off function. This study was to investigate the regulatory expression of human interferon-gamma (IFNgamma) gene in murine bone marrow stromal cells (BMSCs) by Tet-off system., Methods: Plasmid pTre and human IFNgamma gene were digested using Sac II and Xba I, purified, and ligated by T4 ligase. The recombinant pTre-IFNgamma was identified by restriction analysis and sequencing. pTet-off and pTre-IFNgamma were co-transfected into murine BMSCs. Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect IFNgamma mRNA 48 h after transfection. ELISA was used to detect IFNgamma protein in the cell culture medium everyday to analyze the secretary mode of IFNgamma. Then, Tetracycline was added to the culture medium immediately after co-transfection in gradient concentration and 48 h after co-transfection to observe its effect on IFNgamma secretion., Results: Restriction analysis and sequencing confirmed the orientation and sequence of the recombinant plasmid pTre-IFNgamma were correct. RT-PCR detected IFNgamma mRNA in BMSCs 48 h after co-transfection. ELISA showed the secretion of IFNgamma lasted 6 days and a peak appeared in the third 24 h, which was (720.09+/-241.51) pg per 1 x10(6) cells. Increasing tetracycline decreased the secretion of IFNgamma in the first 48 h: 10-100 ng/ml tetracycline decreased the secretion to nearly 0. When tetracycline was added 48 h after co-transfection, the secretion was obviously suppressed 8 h later, and the suppression was strengthened as time went by., Conclusion: The Tet-off system can efficiently and rapidly down-regulate the expression of human IFNgamma gene in murine BMSCs.
- Published
- 2006
142. [Comparing CHOP, CHOP+HD-MTX,and BFM-90 regimens in the survival rate of children and adolescents with B cell non-Hodgkin's lymphoma].
- Author
-
Sun XF, Su YS, Liu DG, Jiang WQ, He YJ, Lin TY, Huang HQ, Zhang L, Xia ZJ, Li YH, Zhou ZM, Chen XQ, Xia Y, Zhen ZJ, and Guan ZZ
- Subjects
- Adolescent, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Child, Child, Preschool, Cyclophosphamide administration & dosage, Doxorubicin administration & dosage, Etoposide administration & dosage, Female, Follow-Up Studies, Humans, Infant, Leucovorin administration & dosage, Lymphoma, B-Cell pathology, Male, Methotrexate administration & dosage, Neoplasm Staging, Prednisone administration & dosage, Survival Rate, Vincristine administration & dosage, Vindesine administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Lymphoma, B-Cell drug therapy
- Abstract
Background & Objectives: B cell non-Hodgkin's lymphoma (B-NHL) in childhood and adolescence is aggressive. Routine CHOP regimen can improve the survival rate of patients with early-stage disease, but its effect on patients with advanced disease was poor. Therefore, it is worthwhile to further investigate how to treat patients with B-NHL at different stages. This study was designed to retrospectively analyze and compare CHOP, CHOP+HD-MTX, and BFM-90 regimens in the survival rate of children and adolescents with B-NHL,and explore the optimal therapeutic strategy and protocols., Methods: Thirty cases of 3- to 17-year-old untreated patients with B-NHL were enrolled in CHOP group, with 13 in Stage I/II, and 17 in stage III/IV (St Jude staging), all patients received standard CHOP for 2 to 8 cycles, the regimen was repeated every 3 weeks. Eighteen cases of 3- to 14-year-old untreated patients with B-NHL were enrolled in CHOP+HD-MTX group, with 6 in Stage I/II, and 12 in stage III/IV (St Jude staging), all patients received CHOP+HD-MTX and intrathecal injection for 2 to 8 cycles, the regimen was repeated every 4 weeks. Twenty-five cases of 1.5- to 15-year-old untreated patients with B-NHL were enrolled in BFM-90 group, with 7 in Stage I/II,and 18 in stage III/IV (St Jude staging). The patients with stage I/II disease received A schema alteration with B schema of BFM-90 regimen for 4 to 6 cycles, while the patients with stage III/IV disease received AA schema alteration with BB schema of BFM-90 regimen for 6 cycles, the interval of cycles was 18-21 days. The survival rates were evaluated by Kaplan-Meier method., Results: In CHOP group,complete response (CR) rate was 70% (21/30), and partial response (PR) rate was 13% (4/30). In CHOP+HD-MTX group, CR rate was 83%, PR rate was 16%. In BFM-90 group, CR rate was 96% (24/25), and PR rate was 4% (1/25). The hematologic toxicity incidence was higher in BFM-90 group than in the other 2 groups. In CHOP group, the overall 2-year survival rate was 52.79% (72.73% for Stage I/II, and 37.82% for stage III/IV). In CHOP+HD-MTX group, the overall 2-year survival rate was 55.56 % (83.33 % for Stage I/II, and 41.67 % for stage III/IV). There was no significant difference between CHOP group and CHOP+HD-MTX group in survival rate (P=0.78). In BFM-90 group,2-year event-free survival rate (EFS) was 84.01 % (100% for Stage I/II, and 77.04 % for stage III/IV). The differences in survival rate between BFM-90 group and CHOP group, CHOP+HD-MTX group were both significant (P=0.013, and P=0.034)., Conclusion: BFM-90 regimen can greatly improve the survival rate of children and adolescents with B-NHL, especially of patients with advanced NHL. CHOP, and CHOP+HD-MTX regimens work better for the early stage patients, but produce low survival rate for patients with advanced NHL. A high intensive chemotherapy like BFM-90 regimen is necessary for children and adolescents with advanced B-NHL.
- Published
- 2004
143. [Effect of monocalcium phosphate and potassium chloride on nitrogen leaching in paddy soil].
- Author
-
Li ST, Zhou JM, Wang HY, Du CW, and Chen XQ
- Subjects
- Ammonia analysis, Drug Synergism, Nitrates analysis, Soil Pollutants analysis, Urea chemistry, Calcium Phosphates chemistry, Fertilizers, Nitrogen analysis, Potassium Chloride chemistry, Soil analysis
- Abstract
In this article, influence of monocalcium phosphate and potassium chloride application on nitrogen leaching in paddy soil of Taihu region was studied by soil column leaching. The results showed that nitrate nitrogen was the main component of nitrogen leaching without urea application which accounts for 93.39 percent of total nitrogen leaching (including urea, ammonium, and nitrate nitrogen). Amounts of urea, ammonium, and nitrate nitrogen in leachates increased significantly after urea application which account for 3.95, 15.25, and 80.80 percent of total nitrogen leaching respectively and for 0.26, 0.80, and 2.54 percent of applied nitrogen respectively. Amounts of urea, ammonium, and nitrate nitrogen in leachates were enhanced prominently by monocalcium phosphate or potassium chloride which are 4.54, 24.11, 71.34, and 3.45, 24.53, 72.02 percent of total nitrogen leaching respectively, and which are 0.39, 1.86, 3.34, and 0.32, 2.12, 4.06 percent of applied nitrogen separately. There is interactive influence on nitrogen leaching after application of monocalcium phosphate and potassium chloride together, and amounts of urea, ammonium, and nitrate nitrogen were 4.10, 27.35, and 68.55 percent of total nitrogen leaching, and 0.42, 2.60, and 4.26 percent of total applied nitrogen respectively. The leaching order of different form nitrogen followed as urea N > ammonium N > nitrate N, and leaching amounts of different form nitrogen followed as urea N < ammonium N < nitrate N.
- Published
- 2004
144. [Evaluation of efficacy of treatment for 30 children with neuroblastoma].
- Author
-
Sun XF, Liu DG, Su YS, Lin TY, Chen XQ, and He YJ
- Subjects
- Antineoplastic Combined Chemotherapy Protocols adverse effects, Child, Child, Preschool, Combined Modality Therapy, Cyclophosphamide administration & dosage, Cyclophosphamide adverse effects, Doxorubicin administration & dosage, Doxorubicin adverse effects, Etoposide administration & dosage, Female, Humans, Infant, Male, Neoplasm Staging, Neuroblastoma drug therapy, Neuroblastoma pathology, Neuroblastoma radiotherapy, Retrospective Studies, Teniposide administration & dosage, Treatment Outcome, Vincristine administration & dosage, Vincristine adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Cyclophosphamide therapeutic use, Doxorubicin therapeutic use, Neuroblastoma therapy, Vincristine therapeutic use
- Abstract
Background & Objective: Neuroblastoma is one of common solid tumors in children. The major treatment modality for neuroblastoma (NB) is chemotherapy combined with operation or irradiation. But the survival rate is still low for advanced patients. Further study is needed for improving cure rate of neuroblastoma. This study was designed to evaluate the efficacy of children with neuroblastoma treated in Cancer Center, Sun Yat-sen University, and to explore reasonable therapy strategy., Methods: The clinical data of 30 children with NB aged from 7 months to 13 years were analyzed retrospectively. These patients were treated with chemotherapy plus operation or radiation. The stages were as follow: II, n=2; III, n=12; IV, n=15; IVS, n=1. Chemotherapy regimen was CAV (cyclophosphamide 750 mg/m(2) d1, vincristine 1.5 mg/m(2), d1, Adriamycin 50 mg/m(2) d1) alternated with EP (teniposide or etoposide 60 mg/m(2) d1-d5, cisplatin 20 mg/m(2) d1-d5). The resection would be done after 4 to 6 cycles of chemotherapy if possible. The chemotherapy or radiation would be done after resection. If operation was not available, the patients continued to receive the chemotherapy. The patients with stage IVS only received cyclophosphamide plus vincristine., Results: Among 30 patients, 2 cases achieved complete remission (CR 6.7%) by chemotherapy alone; 21 cases achieved partial remission (PR 70%); 6 cases showed no change (NC 20%); 1 cases showed progressive diseases (3.3%). Overall response rate (CR+PR) were 76.7% by chemotherapy alone. Of 21 PR patients, 9 cases could be resected;4 cases achieved CR after operation; 1 case achieved CR after radiation. The 2-year overall survival rate was 47.8% for all patients; 100% for Stage II/IVS, 34% for stage III, 22% for stage IV, respectively. Grade III/IV hematological toxicity occurred in 41.2% of the CAV regimen and 26.6% of the EP regimen., Conclusion: Chemotherapy plus operation or radiation is the major treatment for neuroblastoma. CAV/EP alternative chemotherapy is the active regimen for NB. The toxicity is tolerable. Advance stage NB needs further study for improving the prognosis.
- Published
- 2003
145. [Predictive significance of serum 90K/Mac-2BP on chemotherapy response in non-Hodgkin's lymphoma].
- Author
-
Zhang DS, Jiang WQ, Li S, Zhang XS, Mao H, Chen XQ, Li YH, Zhan J, and Wang FH
- Subjects
- Adolescent, Adult, Aged, Antigens, Neoplasm, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Biomarkers, Tumor, Carrier Proteins, Child, Child, Preschool, Cyclophosphamide administration & dosage, Doxorubicin administration & dosage, Female, Glycoproteins, Humans, Lymphoma, Non-Hodgkin blood, Male, Middle Aged, Prednisolone administration & dosage, Vincristine administration & dosage, Lipoproteins blood, Lymphoma, Non-Hodgkin drug therapy, Neoplasm Proteins blood
- Abstract
Background & Objective: For newly diagnosed non-Hodgkin's lymphoma (NHL), CHOP regimen shows good response, but quite a few patients belong to intrinsic drug resistance, or relapse after complete remission (CR). Clinical study has been focused on screening them out and improving the therapeutic response. The purpose of this study was to explore the predictive value of serum 90K/Mac-2BP on chemotherapy response in newly diagnosed NHLs, and to analyze the potential significance of serum 90K/Mac-2BP as a tumor marker in NHLs., Methods: Thirty healthy donors and 100 newly diagnosed patients were included in this study. Serum 90K/Mac-2BP level was measured with the quantitative sandwich enzyme linked immunosorbent assay (ELISA), and the relationship between serum 90K/Mac-2BP level and the therapeutic response as well as clinicopathological features was analyzed., Results: The level of serum 90K/Mac-2BP was associated with the response of the initial treatment in patients who received CHOP (CTX, ADM, VCR, Pred) chemotherapy. The response rate in patients with higher level (mean serum level >13.62 microg/ml) of 90K/Mac-2BP was 47.6% (20/42). The response rate in patients with lower level (mean serum level
0.05)., Conclusion: The level of serum 90K/Mac-2BP might predict the response of CHOP chemotherapy in NHLs, and is hopeful to be a new tumor marker. - Published
- 2003
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