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Your search keyword '"Davies, A.H."' showing total 182 results
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182 results on '"Davies, A.H."'

160. Randomized clinical trial of low molecular weight heparin with thigh-lenght or knee-length antiembolism stockings for patients undergoing surgery.

Author

Howard, A., Zaccagnini, D., Ellis, M., Williams, A., Davies, A.H., and Greenhalgh, R.M.

Subjects
CLINICAL trials, MEDICAL protocols, HEPARIN, COMPRESSION stockings, SURGERY, ANESTHESIA, POSTOPERATIVE care, THROMBOSIS
Abstract

Explains that a randomized clinical trial was conducted to determine the efficacy and safety of a "blanket" protocol of low molecular weight heparin and the best length of antiembolism stocking, for every patient requiring surgery under general anesthesia. Duplex ultrasonography was used to assess the incidence of postoperative deep vein thrombosis.

Published
2004
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161. CORRESPONDENCE.

Author

Reid, Robert, Massey, Graham, Bates, Robin, Porro, G. Bianchi, Petrillo, M., Prada, A., Godding, Edmund W., Gordon, R.R., Lask, Bryan, Waterworth, Pamela M., Lockey, Eunice, Geddes, J.S., Dewar, John A., Transbol, I., Jorgensen, F. Schonau, Lund, B., Sorensen, O.H., and Davies, A.H.

Subjects
MEDICINE, ASTHMA treatment, ASTHMA in children, STEROID drugs, ENDOSCOPY, INDIGESTION
Abstract

Presents several letters on issues related to medicine. Treatment of asthmatic children with steroids; Importance of endoscopy in dyspepsia; Variations in urinary excretion of calcium.

Published
1975

162. Chlamydia pneumoniae and vascular disease.

Author

Gibbs, R. G. J., Carey, N., and Davies, A.H.

Subjects
CHLAMYDOPHILA pneumoniae, ATHEROSCLEROSIS, HEART diseases
Abstract

Background There is an increasing body of evidence linking the human pathogen Chlamydia pneumoniae with atherosclerosis. Methods A Medline-based review of the literature was carried out. Results and conclusion Seroepidemiological studies have revealed the possibility that evidence of infection with C. pneumoniae and atherosclerotic disease are related. Studies on human tissue have demonstrated that evidence of the organism can be found in human atherosclerotic tissue by both direct and indirect methods significantly more often than in control vascular tissue. Using animal models it is possible to show that C. pneumoniae can be disseminated haematogenously following pulmonary infection and that it shows a tropism for atherosclerotic tissue. In vitro work has demonstrated that the organism is capable of infecting, surviving and multiplying in cells of the human vascular wall, and that it can provoke a cell-mediated cytokine response which has implications both locally and systemically. Two clinical trials of macrolide antibiotics have demonstrated that they confer increased cardiovascular protection in patients following myocardial infarction. Adequately powered trials are needed to establish the therapeutic role of antibiotics in peripheral arterial disease. [ABSTRACT FROM AUTHOR]

Published
1998
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163. Editor's Choice – Management of Chronic Venous Disease Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS)

Author

Writing Committee, Wittens, C., Davies, A.H., Bækgaard, N., Broholm, R., Cavezzi, A., Chastanet, S., de Wolf, M., Eggen, C., Giannoukas, A., Gohel, M., Kakkos, S., Lawson, J., Noppeney, T., Onida, S., Pittaluga, P., Thomis, S., Toonder, I., Vuylsteke, M., ESVS Guidelines Committee, Kolh, P., de Borst, G.J., Chakfé, N., Debus, S., Hinchliffe, R., Koncar, I., Lindholt, J., de Ceniga, M.V., Vermassen, F., Verzini, F., Document Reviewers, De Maeseneer, M.G., Blomgren, L., Hartung, O., Kalodiki, E., Korten, E., Lugli, M., Naylor, R., Nicolini, P., and Rosales, A.

Subjects
Stenting, Ambulatory compression, Laser, AVVQ, Venous disease, MRV, Endophlebectomy, Venous malformation, Phlebectomy, AV fistula, Chronic venous disease, Sclerotherapy, Duplex ultrasound, Villalta, Recurrent varicose veins, Compression, Radiofrequency ablation, Phlebography, CEAP, VCSS, Thermal ablation, Plethysmography, Wound dressings, Non-thermal ablation, Varicose veins, CTV, Vein Qol Sym, High ligation, Stripping
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164. Strategic Planning in the Thomas Cook Group

Author

Davies, A.H.

Subjects
Travel, Business planning -- Management, Budget -- Methods, Management -- Planning, Finance -- Management, Business, Business, general, Economics
Published
1981

165. Duplex imaging findings predict stenosis after carotid endarterectomy

Author

Cross, Charing, From the Department of Surgery, Westminster Medical School., Golledge, J., Cuming, R., Ellis, M., Davies, A.H., and Greenhalgh, R.M.

Abstract

Purpose: This study was performed to determine whether early duplex findings predicted restenosis after carotid endarterectomy. Methods: One hundred ninety-two symptomatic patients who underwent carotid endarterectomy were studied with color duplex imaging at 1 day and 1 week after surgery to identify minor residual disease (causing <50% stenosis), arterial kinking, and suture stricture, and to measure the external and luminal diameters of the carotid bulb and distal internal carotid artery. Patients were then observed prospectively with duplex surveillance for a median of 24 months to identify >50% restenosis. Results: Twenty-five stenoses >50% of the operated carotid artery (13%) were identified, four at 1 day (residual) and 21 at a median follow-up of 6 months (restenosis). On multiple logistic regression analysis, >50% restenosis was found to be associated with minor day-1 residual stenosis (p = 0.01) and with small luminal diameter of the distal internal carotid artery (p = 0.03) as measured 1 week after carotid endarterectomy. Life table analysis showed restenosis at 24 months to be more common for patients with below-median than patients with above-median carotid bulb external diameter (18% vs 5%, respectively; p = 0.01). Conclusions: Duplex scanning within a week of carotid endarterectomy identifies >50% residual stenosis, in addition to minor residual 25% to 50% stenosis and small carotid dimensions, which are good predictors of >50% restenosis at 6 months. (J Vasc Surg 1997;26:43-8.)

Published
1997
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166. Carotid plaque characteristics and presenting symptom

Author

Golledge, J., Cuming, R., Ellis, M., Davies, A.H., Greenhalgh, R.M., and Mr

Abstract

Background The importance of identifying features of carotid artery disease, in addition to degree of stenosis, which predict subsequent stroke is becoming increasingly clear. This study assessed the relationship between carotid plaque characteristics and presenting symptoms.
Methods Some 285 symptomatic (transient ischaemic attack (TIA) 127, amaurosis fugax 58, transient stroke 15, established stroke 55, progressive stroke 11, crescendo TIA 19) and 65 asymptomatic patients were studied with colour-flow duplex imaging. All patients had 60-99 per cent internal carotid stenosis. Carotid plaque morphology (classified according to Gray-Weale) and plaque surface features were assessed.
Results Plaque types I and II were more common in symptomatic patients (83 per cent versus 44 per cent; P&lt;0·0001). Plaque surface was classified as smooth (34 per cent), irregular (44 per cent) or ulcerated (22 per cent). Ulceration was also more common in symptomatic patients (23 versus 14 per cent; P=0.04). In symptomatic patients there was no association between presenting symptom and plaque morphology or surface features (P=0·9 and P=0·8 respectively). On multiple regression analysis plaque morphology did not distinguish between patients who presented with stroke without warning and other symptomatic patients (who had TIA, amaurosis fugax, crescendo TIA or stroke with warning).
Conclusion There was an association between echolucent type I and II carotid plaques and the presence of symptoms but not their type. Plaque morphology was not characteristic in a subgroup of patients who had stroke without warning. Further prospective study of plaque morphology in asymptomatic patients might help identify high-risk groups.

Published
1997
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167. Influence of patient-related variables on the outcome of carotid endarterectomy

Author

Golledge, J., Cuming, R., Beattie, D.K., Davies, A.H., and Greenhalgh, R.M.

Abstract

Purpose: Variability in outcome after carotid endarterectomy is well recognized. This study examines the importance of patient-related factors in determining outcome. Methods: Four hundred and sixty consecutive patients undergoing carotid endarterectomy for symptomatic severe (60% to 99%) internal carotid stenosis performed by one vascular surgeon have been studied prospectively. Patients were followed-up at 3, 6, 9, and 12 months and then yearly. Pre-, intra-, and perioperative details and follow-up information were entered on a database. Results: Multiple logistic regression identified a number of factors significantly associated with death and stroke. A history of crescendo transient ischemic attacks (TIAs) (p = 0.003, p = 0.0002) and being female ( p = 0.03, p = 0.0001) were associated with both perioperative death and stroke within 30 days of operation, respectively. Deaths between 1 and 36 months were associated with ischemic heart disease (p = 0.03) and diabetes ( p = 0.04), whereas stroke was associated with small internal carotid diameter ( p = 0.02). The importance of symptoms at presentation on outcome was further emphasized by life-table analysis. In 98% of patients with amaurosis fugax, only 67% of those with crescendo TIAs were alive at 18 months ( p < 0.01). The survival of patients with amaurosis was significantly better than those with TIAs ( p < 0.01), transient stroke ( p < 0.01), and progressive stroke ( p < 0.05). Similarly, postoperative stroke was significantly more common for patients with crescendo TIAs than those with amaurosis ( p < 0.01), established stroke ( p < 0.05), and TIA ( p < 0.05). Transient stroke was associated with a poor outcome, with only 66% of patients being alive at 36 months and 14% having suffered a stroke ( p < 0.05 compared with established stroke). Conclusion: Presenting symptoms significantly predict outcome after carotid endarterectomy. This should be considered both in patient selection and comparison of patient series. (J Vasc Surg 1996;24:120-6.)

Published
1996
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168. Does pressure gradient guided angioplasty improve angioplasty outcome?

Author

Chong, P.F.S., Mitchell, A., Barratt, N., Ellis, M., Brown, L.C., Davies, A.H., Greenhalgh, R.M., and Golledge., J.

Subjects
ANGIOPLASTY, LIFE tables
Abstract

Examines the efficacy of pressure gradient guided angioplasty (PG-PTA). Comparison between PG-PTA and conventional angioplasty; Determinants of hemodynamic and symptomatic success; Performance of life-table analysis.

Published
2001

171. CORRESPONDENCE.

Author

Sugarbaker, P.H., Shmookler, B., Ronnett, B.M., Chang, D., Ambrose, N.S., Guest, M., Smith, J.J., Davies, A.H., Sailer, M., Bussen, D., Debus, E.S., Fuchs, K.-H., Thiede, A., Khan, T.F. Toufeeq, Manas, D.M., and Black, J.

Subjects
LETTERS to the editor, SURGERY, PERIODICALS
Abstract

Presents topical correspondence from readers of the periodical 'British Journal of Surgery,' for the month of June 1999. Pseudomyxoma peritonei; Quality of life in patients with benign anorectal disorders; Anomalous pancreaticobiliary junction without congenital choledochal cyst; Association between breast and colorectal cancers.

Published
1999
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172. Nerve Growth in Cardiac Muscle

Author

Davies, A.H., De Souza, B.A., Glasby, M.A., Gschmeissner, S.E., and Huang, C.L.-H.

Subjects
Original Manuscripts
Abstract

The failure of reinnervation after cardiac transplantation is probably a consequence of scar formation at the suture lines. However, it must be established whether there are any intrinsic properties of the muscle that prevent reinnervation. This is examined in experimental peripheral nerve implants using cardiac muscle isografts. The results show extensive growth of regenerating axons into the implanted cardiac muscle. It is therefore unlikely that the failure of reinnervation depends upon the physical or chemical properties of the muscle itself.

Published
1986

174. A protocol of low molecular weight heparin and antiembolic stockings abolishes deep vein thrombosis in low and moderate-risk patients and reduces it in high-risk surgical patients.

Author

Howard, A., Zaccagnini, D., Williams, A., Ellis, M., Salooja, N., Davies, A.H., and Greenhalgh, R.M.

Subjects
MEDICAL protocols, THROMBOSIS, HEPARIN, COMPRESSION stockings
Abstract

Aims: In our acute university, multidisciplinary hospital we found a disparate use of thromboprophylaxis with regard to types and implementation of subcutaneous heparin and antiembolic stockings. Our goal was to investigate the efficacy and safety of a single 'blanket' thromboprophylaxis protocol of fractionated heparin combined with the best length and type of stocking given to every patient requiring surgery, under general anaesthesia. Methods: We interviewed 426 patients; 376 were randomized into three stocking groups, Medi 'Thrombexin' thigh-length, 'Thrombexin' knee-length and Kendall 'TED' thigh-length. All patients received daily fractionated heparin. Incidence of deep vein thrombosis (DVT) was assessed by duplex ultrasound. Results: No DVT occurred in the low or moderate DVT risk patients (n = 85) using this protocol. All postoperative DVT occurred in the patients from the high-risk group. Nineteen patients developed DVT from two hundred and ninety one high risk patients. DVT occurred in two patients with 'Thrombexin' thigh-length stockings and eleven with 'Thrombexin' knee-length (P < 0·05). Six patients wearing 'TED' thigh-length stockings developed DVT. Each group was statistically similar for age, gender, thromboembolic risk, surgical type and protocol compliance. One significant bleeding complication occurred. Conclusions: A single protocol employing fractionated heparin and thigh stockings for all surgical patients abolishes DVT diagnosed by duplex in low and moderaterisk patients and reduces DVT by duplex to 2% in the high-risk patients, with only one significant bleeding complication. Blanket thromboprophylaxis with fractionated heparin and good quality thigh-length stockings is safe and effective to use in all surgical patients with minimal bleeding risk. [ABSTRACT FROM AUTHOR]

Published
2003

175. Evaluating quality-of-life changes in intermittent claudication.

Author

Chong, P.F.S., Garratt, A.M., Golledge, J., Greenhalgh, R.M., and Davies, A.H.

Subjects
QUALITY of life, INTERMITTENT claudication, ANGIOPLASTY
Abstract

Examines the quality of life of patients undergoing intermittent claudication (IC). Assessment of resting ankle pressure in preparation for angioplasty; Use of symptom-specific questionnaire (SSQ) to test patient responsiveness to IC; Comparison between SSQ and Walking Impairment Questionnaire.

Published
2001
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178. Optimal management of asymptomatic carotid stenosis in 2021: the jury is still out. An international, multispecialty, expert review and position statement

Author

Ian M. Loftus, Andrew Nicolaides, Luca Saba, Pier Luigi Antignani, Mauro Silvestrini, Mateja Kaja Jezovnik, Reinoud P H Bokkers, Armando Mansilha, Christos D. Liapis, Niki Katsiki, Jasjit S. Suri, Jean-Baptiste Ricco, Michael Knoflach, Clark J. Zeebregts, Sherif Sultan, Francesco Stilo, José Fernandes e Fernandes, Felix Schlachetzki, Richard P. Cambria, Peter Gloviczki, Gaetano Lanza, Kosmas I. Paraskevas, Seemant Chaturvedi, Dimitri P. Mikhailidis, Tatjana Rundek, Pavel Poredos, Gustav Fraedrich, Jonathan Golledge, Alun H. Davies, M. Eline Kooi, Hans-Henning Eckstein, Antoine Millon, Stavros K. Kakkos, Gianluca Faggioli, George Geroulakos, Ajay Gupta, Rodolfo Pini, Peter A. Ringleb, Alan Dardik, Francesco Spinelli, Hediyeh Baradaran, Thomas S. Riles, Paraskevas K.I., Mikhailidis D.P., Antignani P.L., Baradaran H., Bokkers R.P.H., Cambria R.P., Dardik A., Davies A.H., Eckstein H.-H., Faggioli G., e Fernandes J.F., Fraedrich G., Geroulakos G., Gloviczki P., Golledge J., Gupta A., Jezovnik M.K., Kakkos S.K., Katsiki N., Knoflach M., Kooi M.E., Lanza G., Liapis C.D., Loftus I.M., Mansilha A., Millon A., Nicolaides A.N., Pini R., Poredos P., Ricco J.-B., Riles T.S., Ringleb P.A., Rundek T., Saba L., Schlachetzki F., Silvestrini M., Spinelli F., Stilo F., Sultan S., Suri J.S., Zeebregts C.J., and Chaturvedi S.

Subjects
Male, medicine.medical_treatment, Carotid endarterectomy, GUIDELINES, DISEASE, law.invention, Randomized controlled trial, Risk Factors, law, Stroke, Asymptomatic carotid stenosis, ENDARTERECTOMY, Rehabilitation, Fibrous cap, ASSOCIATION, COUNCIL, Carotid plaque, Plaque, Atherosclerotic, Best medical treatment, MEDICAL-TREATMENT, Carotid Arteries, ISCHEMIC-STROKE, medicine.anatomical_structure, Practice Guidelines as Topic, CEREBRAL HEMODYNAMICS, medicine.symptom, Cardiology and Cardiovascular Medicine, Human, medicine.medical_specialty, SOCIETY, Asymptomatic, Intervention (counseling), Carotid stenosis, medicine, Humans, Risk factor, RECURRENCE, Intensive care medicine, HEALTH-CARE PROFESSIONALS, STROKE PREVENTION, business.industry, Asymptomatic carotid stenosi, medicine.disease, carotid, Stenosis, Surgery, Neurology (clinical), PRIMARY PREVENTION, business, TASK-FORCE
Abstract

The recommendations of international guidelines for the management of asymptomatic carotid stenosis (ACS) often vary considerably and extend from a conservative approach with risk factor modification and best medical treatment (BMT) alone, to a more aggressive approach with a carotid intervention plus BMT. The aim of the current multispecialty position statement was to reconcile the conflicting views on the topic. A literature review was performed with a focus on data from recent studies. Several clinical and imaging high-risk features have been identified that are associated with an increased long-term ipsilateral ischemic stroke risk in patients with ACS. Such high-risk clinical/imaging features include intraplaque hemorrhage, impaired cerebrovascular reserve, carotid plaque echolucency/ulceration/ neovascularization, a lipid-rich necrotic core, a thin or ruptured fibrous cap, silent brain infarction, a contralateral transient ischemic attack/stroke episode, male patients

Published
2022

179. Management of patients with asymptomatic carotid stenosis may need to be individualized: a multidisciplinary call for action

Author

Niki Katsiki, Francesco Stilo, Christos D. Liapis, Ian M. Loftus, Mateja K Jezovnik, Hediyeh Baradaran, Rodolfo Pini, Gaetano Lanza, Sherif Sultan, Kosmas I. Paraskevas, Seemant Chaturvedi, Dimitri P. Mikhailidis, Tatjana Rundek, José Fernandes e Fernandes, Gianluca Faggioli, Andrew Nicolaides, Luca Saba, Francesco Spinelli, Ajay Gupta, M. Eline Kooi, Stavros K. Kakkos, Pavel Poredos, Clark J. Zeebregts, Hans-Henning Eckstein, Antoine Millon, Jean-Baptiste Ricco, Alun H. Davies, Paraskevas K.I., Mikhailidis D.P., Baradaran H., Davies A.H., Eckstein H.-H., Faggioli G., E Fernandes J.F., Gupta A., Jezovnik M.K., Kakkos S.K., Katsiki N., Kooi M.E., Lanza G., Liapis C.D., Loftus I.M., Millon A., Nicolaides A.N., Poredos P., Pini R., Ricco J.-B., Rundek T., Saba L., Spinelli F., Stilo F., Sultan S., Zeebregts C.J., and Chaturvedi S.

Subjects
Life expectancy, SCORING SYSTEM, medicine.medical_treatment, Review, Carotid endarterectomy, Stroke, Endarterectomy, RISK, OUTCOMES, medicine.diagnostic_test, Ischemic attack, Carotid stenosi, ddc, Cardiology, SURVIVAL, medicine.symptom, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, Endarterectomy, carotid, medicine.medical_specialty, Clinical Neurology, VASCULAR-SURGERY, Asymptomatic, Ischemic attack, transient, transient, Internal medicine, medicine, Carotid stenosis, Diseases of the circulatory (Cardiovascular) system, Patient preference, Science & Technology, business.industry, STROKE PREVENTION, ARTERY STENOSIS, MORTALITY, Magnetic resonance imaging, 1103 Clinical Sciences, Vascular surgery, medicine.disease, Transcranial Doppler, carotid, Stenosis, Life expec-tancy, Peripheral Vascular Disease, RC666-701, Cardiovascular System & Cardiology, Neurology (clinical), Neurosciences & Neurology, business, 1109 Neurosciences, PERSONALIZED-MEDICINE
Abstract

The optimal management of patients with asymptomatic carotid stenosis (ACS) is the subject of extensive debate. According to the 2017 European Society for Vascular Surgery guidelines, carotid endarterectomy should (Class IIa; Level of Evidence: B) or carotid artery stenting may be considered (Class IIb; Level of Evidence: B) in the presence of one or more clinical/imaging characteristics that may be associated with an increased risk of late ipsilateral stroke (e.g., silent embolic infarcts on brain computed tomography/magnetic resonance imaging, progression in the severity of ACS, a history of contralateral transient ischemic attack/stroke, microemboli detection on transcranial Doppler, etc.), provided documented perioperative stroke/death rates are 5 years. Besides these clinical/imaging characteristics, there are additional individual, ethnic/racial or social factors that should probably be evaluated in the decision process regarding the optimal management of these patients, such as individual patient needs/patient choice, patient compliance with best medical treatment, patient sex, culture, race/ethnicity, age and comorbidities, as well as improvements in imaging/operative techniques/outcomes. The present multispecialty position paper will present the rationale why the management of patients with ACS may need to be individualized.

Published
2021

180. Management of patients with asymptomatic carotid stenosis may need to be individualized: A multidisciplinary call for action. Republication of J Stroke 2021;23:202-12

Author

Paraskevas K. I., Mikhailidis D. P., Baradaran H., Davies A. H., Eckstein H. -H., Faggioli G., Fernandes E Fernandes J., Gupta A., Jezovnik M. K., Kakkos S. K., Katsiki N., Kooi M. E., Lanza G., Liapis C. D., Loftus I. M., Millon A., Nicolaides A. N., Poredos P., Pini R., Ricco J. -B., Rundek T., Saba L., Spinelli F., Stilo F., Sultan S., Zeebregts C. J., Chaturvedi S., Paraskevas K.I., Mikhailidis D.P., Baradaran H., Davies A.H., Eckstein H.-H., Faggioli G., Fernandes E Fernandes J., Gupta A., Jezovnik M.K., Kakkos S.K., Katsiki N., Kooi M.E., Lanza G., Liapis C.D., Loftus I.M., Millon A., Nicolaides A.N., Poredos P., Pini R., Ricco J.-B., Rundek T., Saba L., Spinelli F., Stilo F., Sultan S., Zeebregts C.J., and Chaturvedi S.

Subjects
Stroke, Endarterectomy, Carotid, Ischemic Attack, Transient, Risk Factor, Carotid Stenosi, Human
Abstract

The optimal management of patients with asymptomatic carotid stenosis (ACS) is the subject of extensive debate. According to the 2017 European Society for Vascular Surgery Guidelines, carotid endarterectomy should (Class IIa; Level of Evidence: B) or carotid artery stenting may be considered (Class IIb; Level of Evidence: B) in the presence of one or more clinical/imaging characteristics that may be associated with an increased risk of late ipsilateral stroke (e.g. silent embolic infarcts on brain computed tomography/magnetic resonance imaging, progression in the severity of ACS, a history of contralateral transient ischemic attack/stroke, microemboli detection on transcranial Doppler, etc.), provided documented perioperative stroke/death rates are 5 years. Besides these clinical/imaging characteristics, there are additional individual, ethnic/racial or social factors that should probably be evaluated in the decision process regarding the optimal management of these patients, such as individual patient needs/patient choice, patient compliance with best medical treatment, patient sex, culture, race/ethnicity, age and comorbidities, as well as improvements in imaging/operative techniques/outcomes. The present multispecialty position paper will present the rationale why the management of patients with ACS may need to be individualized.

Published
2021

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