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1,250 results on '"Dekker, Jacqueline M."'

301. Non-HDL cholesterol contributes to the 'hypertriglyceridemic waist' as a cardiovascular risk factor: the Hoorn study

Author

Bos, Griet, Dekker, Jacqueline M., and Heine, Robert J.

Subjects
Coronary heart disease -- Risk factors, Men -- Health aspects -- Analysis, Disease susceptibility -- Risk factors, Health, Analysis, Risk factors, Health aspects
Abstract

Lemieux et al. (1) described the 'hypertriglyceridemic waist' as a marker of the atherogenic metabolic triad (hyperinsulinemia, hyperapolipoprotein B, and small, dense LDL) in men. In 287 men, those with [...]

Published
2004

302. Associations of adiponectin levels with incident impaired glucose metabolism and type 2 diabetes in older men and women: The Hoorn Study

Author

Snijder, Marieke B, Heine, Robert J, Seidell, Jacob C, Bouter, Lex M, Stehouwer, Coen D A, Nijpels, Giel, Funahashi, Tohru, Matsuzawa, Yuji, Shimomura, Iichiro, Dekker, Jacqueline M, Snijder, Marieke B, Heine, Robert J, Seidell, Jacob C, Bouter, Lex M, Stehouwer, Coen D A, Nijpels, Giel, Funahashi, Tohru, Matsuzawa, Yuji, Shimomura, Iichiro, and Dekker, Jacqueline M

Abstract

OBJECTIVE: Adiponectin is an adipose tissue-derived protein. Low levels are associated with obesity, insulin resistance, and type 2 diabetes. Our objective was to investigate the prospective association between adiponectin levels and the 6.4-year risk of type 2 diabetes and of impaired glucose metabolism (IGM).RESEARCH DESIGN AND METHODS: The Hoorn Study is a cohort study among Caucasians, aged 50-75 years. BMI, waist-to-hip ratio (WHR), fasting glucose, 2-h glucose, triglycerides, HDL cholesterol, LDL cholesterol, alanine aminotransferase, leptin, and adiponectin were measured at baseline. Lifestyle (alcohol intake, smoking, and physical activity) was assessed by questionnaires. After a mean follow-up of 6.4 years, glucose tolerance was assessed by a 75-g oral glucose tolerance test. Analyses were performed in 1,264 subjects (584 men and 680 women) without type 2 diabetes at baseline. For analyses of incident IGM, 239 subjects with IGM at baseline and/or type 2 diabetes at follow-up were excluded.RESULTS: Age- and lifestyle-adjusted odds ratios and 95% CIs comparing highest with lowest adiponectin quartile were 0.52 (0.23-1.18) in men and 0.15 (0.06-0.39) in women for type 2 diabetes and 0.90 (0.51-1.61) and 0.28 (0.16-0.48) for IGM, respectively. The risks were only slightly reduced after adjustment for WHR and leptin as markers of (abdominal) adiposity. Adjustment for baseline fasting and postload glucose levels (potential mediators) substantially diminished these inverse associations with type 2 diabetes (0.79 [0.32-1.91] and 0.62 [0.21-1.81]) and with IGM (1.20 [0.61-2.35] and 0.48 [0.26-0.90]), respectively.CONCLUSIONS: A high adiponectin level was strongly associated with a lower risk of IGM and type 2 diabetes, particularly in women. These results suggest that adiponectin is involved in the pathophysiology linking obesity to type 2 diabetes.

Published
2006
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303. The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility:the DAMAGE study

Author

van Hove, Els C, Hansen, Torben, Dekker, Jacqueline M, Reiling, Erwin, Nijpels, Giel, Jørgensen, Torben, Borch-Johnsen, Knut, Hamid, Yasmin H, Heine, Robert J, Pedersen, Oluf, Maassen, J Antonie, hart, Leen M, van Hove, Els C, Hansen, Torben, Dekker, Jacqueline M, Reiling, Erwin, Nijpels, Giel, Jørgensen, Torben, Borch-Johnsen, Knut, Hamid, Yasmin H, Heine, Robert J, Pedersen, Oluf, Maassen, J Antonie, and hart, Leen M

Abstract

The short-chain l-3-hydroxyacyl-CoA dehydrogenase (SCHAD) protein is involved in the penultimate step of mitochondrial fatty acid oxidation. Previously, it has been shown that mutations in the corresponding gene (HADHSC) are associated with hyperinsulinism in infancy. The presumed function of the SCHAD enzyme in glucose-stimulated insulin secretion led us to the hypothesis that common variants in HADHSC on chromosome 4q22-26 might be associated with development of type 2 diabetes. In this study, we have performed a large-scale association study in four different cohorts from the Netherlands and Denmark (n = 7,365). Direct sequencing of HADHSC cDNA and databank analysis identified four tagging single nucleotide polymorphisms (SNPs) including one missense variant (P86L). Neither the SNPs nor haplotypes investigated were associated with the disease, enzyme function, or any relevant quantitative measure (all P > 0.1). The present study provides no evidence that the specific HADHSC variants or haplotypes examined do influence susceptibility to develop type 2 diabetes. We conclude that it is unlikely that variation in HADHSC plays a major role in the pathogenesis of type 2 diabetes in the examined cohorts.

Published
2006

304. Retinopathy is associated with cardiovascular and all-cause mortality in both diabetic and nondiabetic subjects: the Hoorn Study

Author

van Hecke, Manon V., Dekker, Jacqueline M., Nijpels, Giel, Moll, Annette C., van Leiden, Hendrik A., Heine, Robert J., Bouter, Lex M., Stehouwer, Coen D.A., and Polak, Bettine C.P.

Subjects
Diabetic retinopathy -- Complications and side effects -- Risk factors, Cardiovascular diseases -- Risk factors -- Complications and side effects, Health, Complications and side effects, Risk factors
Abstract

Diabetic retinopathy has been associated with increased cardiovascular and all-cause mortality risks among diabetic populations (1). The exact mechanism of this association, however, still remains unclear (1). Recently, we reported [...]

Published
2003

305. Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene

Author

hart, Leen M, Hansen, Torben, Rietveld, Ingrid, Dekker, Jacqueline M, Nijpels, Giel, Janssen, George M C, Arp, Pascal A, Uitterlinden, André G, Jørgensen, Torben, Borch-Johnsen, Knut, Pols, Huibert A P, Pedersen, Oluf, van Duijn, Cornelia M, Heine, Robert J, Maassen, J Antonie, hart, Leen M, Hansen, Torben, Rietveld, Ingrid, Dekker, Jacqueline M, Nijpels, Giel, Janssen, George M C, Arp, Pascal A, Uitterlinden, André G, Jørgensen, Torben, Borch-Johnsen, Knut, Pols, Huibert A P, Pedersen, Oluf, van Duijn, Cornelia M, Heine, Robert J, and Maassen, J Antonie

Abstract

Previously, we have shown that a mutation in the mitochondrial DNA-encoded tRNA(Leu(UUR)) gene is associated with type 2 diabetes. One of the consequences of this mutation is a reduced aminoacylation of tRNA(Leu(UUR)). In this study, we have examined whether variants in the leucyl tRNA synthetase gene (LARS2), involved in aminoacylation of tRNA(Leu(UUR)), associate with type 2 diabetes. Direct sequencing of LARS2 cDNA from 25 type 2 diabetic subjects revealed eight single nucleotide polymorphisms. Two of the variants were examined in 7,836 subjects from four independent populations in the Netherlands and Denmark. A -109 g/a variant was not associated with type 2 diabetes. Allele frequencies for the other variant, H324Q, were 3.5% in type 2 diabetic and 2.7% in control subjects, respectively. The common odds ratio across all four studies was 1.40 (95% CI 1.12-1.76), P = 0.004. There were no significant differences in clinical variables between carriers and noncarriers. In this study, we provide evidence that the LARS2 gene may represent a novel type 2 diabetes susceptibility gene. The mechanism by which the H324Q variant enhances type 2 diabetes risk needs to be further established. This is the first report of association between an aminoacyl tRNA synthetase gene and disease. Our results further highlight the important role of mitochondria in glucose homeostasis.

Published
2005

309. Prospective Associations of B-Type Natriuretic Peptide With Markers of Left Ventricular Function in Individuals With and Without Type 2 Diabetes

Author

Kroon, Maria H., primary, van den Hurk, Katja, additional, Alssema, Marjan, additional, Kamp, Otto, additional, Stehouwer, Coen D.A., additional, Henry, Ronald M.A., additional, Diamant, Michaela, additional, Boomsma, Frans, additional, Nijpels, Giel, additional, Paulus, Walter J., additional, and Dekker, Jacqueline M., additional

Published
2012
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310. Different Type of Carotid Arterial Wall Remodeling in Rheumatoid Arthritis Compared with Healthy Subjects: A Case-Control Study

Author

VAN SIJL, ALPER M., primary, VAN DEN HURK, KATJA, additional, PETERS, MIKE J.L., additional, VAN HALM, VOKKO P., additional, NIJPELS, GIEL, additional, STEHOUWER, COEN D.A., additional, SMULDERS, YVO M., additional, VOSKUYL, ALEXANDRE E., additional, DEKKER, JACQUELINE M., additional, and NURMOHAMED, MICHAEL T., additional

Published
2012
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313. Common Carotid Intima-Media Thickness Measurements in Cardiovascular Risk Prediction

Author

Den Ruijter, Hester M., primary, Peters, Sanne A. E., additional, Anderson, Todd J., additional, Britton, Annie R., additional, Dekker, Jacqueline M., additional, Eijkemans, Marinus J., additional, Engström, Gunnar, additional, Evans, Gregory W., additional, de Graaf, Jacqueline, additional, Grobbee, Diederick E., additional, Hedblad, Bo, additional, Hofman, Albert, additional, Holewijn, Suzanne, additional, Ikeda, Ai, additional, Kavousi, Maryam, additional, Kitagawa, Kazuo, additional, Kitamura, Akihiko, additional, Koffijberg, Hendrik, additional, Lonn, Eva M., additional, Lorenz, Matthias W., additional, Mathiesen, Ellisiv B., additional, Nijpels, Giel, additional, Okazaki, Shuhei, additional, O’Leary, Daniel H., additional, Polak, Joseph F., additional, Price, Jackie F., additional, Robertson, Christine, additional, Rembold, Christopher M., additional, Rosvall, Maria, additional, Rundek, Tatjana, additional, Salonen, Jukka T., additional, Sitzer, Matthias, additional, Stehouwer, Coen D. A., additional, Witteman, Jacqueline C., additional, Moons, Karel G., additional, and Bots, Michiel L., additional

Published
2012
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317. Correction: Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp

Author

van Vliet-Ostaptchouk, Jana V., primary, van Haeften, Timon W., additional, Landman, Gijs W. D., additional, Reiling, Erwin, additional, Kleefstra, Nanne, additional, Bilo, Henk J. G., additional, Klungel, Olaf H., additional, de Boer, Anthonius, additional, van Diemen, Cleo C., additional, Wijmenga, Cisca, additional, Boezen, H. Marike, additional, Dekker, Jacqueline M., additional, van 't Riet, Esther, additional, Nijpels, Giel, additional, Welschen, Laura M. C., additional, Zavrelova, Hata, additional, Bruin, Elinda J., additional, Elbers, Clara C., additional, Bauer, Florianne, additional, Onland-Moret, N. Charlotte, additional, van der Schouw, Yvonne T., additional, Grobbee, Diederick E., additional, Spijkerman, Annemieke M. W., additional, van der A, Daphne L., additional, Simonis-Bik, Annemarie M., additional, Eekhoff, Elisabeth M. W., additional, Diamant, Michaela, additional, Kramer, Mark H. H., additional, Boomsma, Dorret I., additional, de Geus, Eco J., additional, Willemsen, Gonneke, additional, Slagboom, P. Eline, additional, Hofker, Marten H., additional, and 't Hart, Leen M., additional

Published
2012
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323. One Risk Assessment Tool for Cardiovascular Disease, Type 2 Diabetes, and Chronic Kidney Disease

Author

Alssema, Marjan, primary, Newson, Rachel S., additional, Bakker, Stephan J.L., additional, Stehouwer, Coen D.A., additional, Heymans, Martijn W., additional, Nijpels, Giel, additional, Hillege, Hans L., additional, Hofman, Albert, additional, Witteman, Jacqueline C.M., additional, Gansevoort, Ron T., additional, and Dekker, Jacqueline M., additional

Published
2012
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324. Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp

Author

van Vliet-Ostaptchouk, Jana V., primary, van Haeften, Timon W., additional, Landman, Gijs W. D., additional, Reiling, Erwin, additional, Kleefstra, Nanne, additional, Bilo, Henk J. G., additional, Klungel, Olaf H., additional, de Boer, Anthonius, additional, van Diemen, Cleo C., additional, Wijmenga, Cisca, additional, Boezen, H. Marike, additional, Dekker, Jacqueline M., additional, van 't Riet, Esther, additional, Nijpels, Giel, additional, Welschen, Laura M. C., additional, Zavrelova, Hata, additional, Bruin, Elinda J., additional, Elbers, Clara C., additional, Bauer, Florianne, additional, Onland-Moret, N. Charlotte, additional, van der Schouw, Yvonne T., additional, Grobbee, Diederick E., additional, Spijkerman, Annemieke M. W., additional, van der A, Daphne L., additional, Simonis-Bik, Annemarie M., additional, Eekhoff, Elisabeth M. W., additional, Diamant, Michaela, additional, Kramer, Mark H. H., additional, Boomsma, Dorret I., additional, de Geus, Eco J., additional, Willemsen, Gonneke, additional, Slagboom, P. Eline, additional, Hofker, Marten H., additional, and 't Hart, Leen M., additional

Published
2012
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329. Vitamin D, cardiovascular disease and mortality

Author

Pilz, Stefan, primary, Tomaschitz, Andreas, additional, März, Winfried, additional, Drechsler, Christiane, additional, Ritz, Eberhard, additional, Zittermann, Armin, additional, Cavalier, Etienne, additional, Pieber, Thomas R., additional, Lappe, Joan M., additional, Grant, William B., additional, Holick, Michael F., additional, and Dekker, Jacqueline M., additional

Published
2011
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330. Long-term Exposure to Traffic-related Air Pollution and Type 2 Diabetes Prevalence in a Cross-sectional Screening-study in the Netherlands

Author

Dijkema, Marieke BA, primary, Mallant, Sanne F, additional, Gehring, Ulrike, additional, van den Hurk, Katja, additional, Alssema, Marjan, additional, van Strien, Rob T, additional, Fischer, Paul H, additional, Nijpels, Giel, additional, Stehouwer, Coen DA, additional, Hoek, Gerard, additional, Dekker, Jacqueline M, additional, and Brunekreef, Bert, additional

Published
2011
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333. Progression and Regression: Distinct Developmental Patterns of Diabetic Retinopathy in Patients With Type 2 Diabetes Treated in the Diabetes Care System West-Friesland, the Netherlands

Author

Zavrelova, Hata, primary, Hoekstra, Trynke, additional, Alssema, Marjan, additional, Welschen, Laura M.C., additional, Nijpels, Giel, additional, Moll, Annette C., additional, de Vet, Henrica C.W., additional, Polak, Bettine C.P., additional, and Dekker, Jacqueline M., additional

Published
2011
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336. The Impact of Genetic Variation in theG6PC2Gene on Insulin Secretion Depends on Glycemia

Author

Heni, Martin, primary, Ketterer, Caroline, additional, Hart, Leen M. 't, additional, Ranta, Felicia, additional, van Haeften, Timon W., additional, Eekhoff, Elisabeth M., additional, Dekker, Jacqueline M., additional, Boomsma, Dorret I., additional, Nijpels, Giel, additional, Kramer, Mark H., additional, Diamant, Michaela, additional, Simonis-Bik, Annemarie M., additional, Heine, Robert J., additional, de Geus, Eco J., additional, Schäfer, Silke A., additional, Machicao, Fausto, additional, Ullrich, Susanne, additional, Thamer, Claus, additional, Stefan, Norbert, additional, Staiger, Harald, additional, Häring, Hans-Ulrich, additional, and Fritsche, Andreas, additional

Published
2010
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339. Slightly elevated B‐type natriuretic peptide levels in a non‐heart failure range indicate a worse left ventricular diastolic function in individuals with, as compared with individuals without, type 2 diabetes: the Hoorn Study

Author

van den Hurk, Katja, primary, Alssema, Marjan, additional, Kamp, Otto, additional, Henry, Ronald M., additional, Stehouwer, Coen D., additional, Diamant, Michaela, additional, Boomsma, Frans, additional, Heine, Rob J., additional, Nijpels, Giel, additional, Paulus, Walter J., additional, and Dekker, Jacqueline M., additional

Published
2010
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341. Fasting cholesteryl ester transfer protein concentration is independently associated with the postprandial decrease in high-density lipoprotein cholesterol concentration after fat-rich meals: the Hoorn prandial study

Author

Alssema, Marjan, primary, El-Harchaoui, Karim, additional, Schindhelm, Roger K., additional, Diamant, Michaela, additional, Nijpels, Giel, additional, Kostense, Piet J., additional, Teerlink, Tom, additional, Heine, Robert J., additional, Dallinga-Thie, Geesje M., additional, Kuivenhoven, Jan A., additional, Dekker, Jacqueline M., additional, and Scheffer, Peter G., additional

Published
2010
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346. The Association of Mitochondrial Content with Prevalent and Incident Type 2 Diabetes

Author

Reiling, Erwin, primary, Ling, Charlotte, primary, Uitterlinden, André G., primary, van't Riet, Esther, primary, Welschen, Laura M. C., primary, Ladenvall, Claes, primary, Almgren, Peter, primary, Lyssenko, Valeriya, primary, Nijpels, Giel, primary, van Hove, Els C., primary, Maassen, Johannes A., primary, de Geus, Eco J. C., primary, Boomsma, Dorret I., primary, Dekker, Jacqueline M., primary, Groop, Leif, primary, Willemsen, Gonneke, primary, and 't Hart, Leen M., primary

Published
2010
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349. The association between the −374T/A polymorphism of the receptor for advanced glycation endproducts gene and blood pressure and arterial stiffness is modified by glucose metabolism status: the Hoorn and CoDAM studies

Author

Engelen, Lian, primary, Ferreira, Isabel, additional, Gaens, Katrien HJ, additional, Henry, Ronald MA, additional, Dekker, Jacqueline M, additional, Nijpels, Giel, additional, Heine, Robert J, additional, 't Hart, Leen M, additional, van Greevenbroek, Marleen MJ, additional, van der Kallen, Carla JH, additional, Blaak, Ellen E, additional, Feskens, Edith JM, additional, ten Cate, Hugo, additional, Stehouwer, Coen DA, additional, and Schalkwijk, Casper G, additional

Published
2010
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