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According to the authors of recent research published in the journal Analyst, 'TAAs (tumor-associated antigens) microarrays were designed to detect auto-antibodies directly in patient sera. Twelve different probes were chosen [...]

Current study results from the report, 'Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia,' have been published. According to the authors of a study from Oviedo, Spain, 'Chronic lymphocytic [...]

'While high serum concentrations of immunoglobulin M (IgM) protein are responsible for much of the morbidity associated with Waldenstrom's macroglobulinemia (WM), the mechanisms controlling IgM secretion in this malignancy remain [...]

'Antibodies to beta(2) glycoprotein I (IgG and IgM isotypes) have recently been added to the laboratory criteria of the revised antiphospholipid syndrome classification criteria. We investigated whether IgM anti-beta(2)-glycoprotein I [...]

A new study, 'White blood cell count at diagnosis and immunoglobulin variable region gene mutations are independent predictors of treatment-free survival in young patients with stage A chronic lymphocytic leukemia,' [...]

In this recent report, researchers in New Delhi, India conducted a study 'To investigate the prevalence of positive serologic findings for celiac disease in Indian women with poor reproductive performance. [...]

A report, 'Genome-wide association study identifies susceptibility loci for IgA nephropathy,' is newly published data in Nature Genetics. According to recent research from New York City, United States, 'We carried [...]

Fresh data on Immunoglobulins are presented in the report 'Topology of the membrane-bound form of complement protein C9 probed by glycosylation mapping, anti-peptide antibody binding, and disulfide modification.' 'The two [...]

Data detailed in 'Immunoglobulin isotypes and functional anti-FVIII antibodies in response to FVIII treatment in Balb/c and C57BL/6 haemophilia A mice' have been presented. 'Previous studies have demonstrated that genetic [...]

Current study results from the report, 'Epitope motif of an anti-nitrotyrosine antibody specific for tyrosine-nitrated peptides revealed by a combination of affinity approaches and mass spectrometry,' have been published. According [...]

Current study results from the report, 'A robust immunohistochemical assay for detecting PTEN expression in human tumors,' have been published. According to recent research from Salt Lake City, United States, [...]

Research findings, 'Advances in the understanding of the Fc gamma receptors-mediated autoantibodies uptake,' are discussed in a new report. 'Receptors for the Fc fragment of immunoglobulin G (Fc?Rs) are important [...]

'Low-density lipoprotein (LDL) particles accumulate in the arterial wall and become oxidized during atherogenesis, leading to the formation of atherosclerotic plaques. The major protein of the LDL particle, apolipoprotein B-100 [...]

Researchers detail in 'Hypophosphorylated and inactive Pyk2 associates with paxillin at the microtubule organizing center in hematopoietic cells,' new data in Immunoglobulins. 'Pyk2 is a non-receptor tyrosine kinase that regulates [...]

'One of the major attendant complications of multiple myeloma is renal injury, which contributes significantly to morbidity and mortality in this disease. Monoclonal immunoglobulin free light chains (FLCs) are usually [...]

New investigation results, 'Immunoglobulin light chains activate nuclear factor-?B in renal epithelial cells through a Src-dependent mechanism,' are detailed in a study published in Blood. 'One of the major attendant [...]

Scientists discuss in 'Monoclonal immunoglobulin light and heavy chain deposition diseases: molecular models of common renal diseases' new findings in Renal Disease. According to a study from Paris, France, 'Light, [...]

A new study, 'A high-affinity recombinant antibody permits rapid and sensitive direct detection of myeloperoxidase,' is now available. According to a study from Dublin, Ireland, 'Over the past 10 years, [...]

Fresh data on B-Cell Leukemia are presented in the report 'Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity.' 'The adapter protein Slp65 and Bruton's tyrosine kinase [...]

According to recent research published in the journal Xenotransplantation, 'A number of carbohydrate structures apart from Gal alpha 1-3Gal beta 1-4GlcNAc (Gal) have been implicated as potential xenoantigens. Epitopes of [...]

Fresh data on Immunoglobulins are presented in the report 'Adult combined GH, prolactin, and TSH deficiency associated with circulating PIT-1 antibody in humans.' According to recent research from Kobe, Japan, [...]

Research findings, 'The absence of VPAC2 leads to aberrant antibody production in Aspergillus fumigatus sensitized and challenged mice,' are discussed in a new report. 'Vasoactive intestinal peptide (VIP) facilitates a [...]

'Chlamydia pneumoniae may trigger atherogenesis. Chlamydia trachomatis (CT) can also induce endothelial activation,' investigators in Brazil report (see also Chlamydia). 'However, its role in metabolic syndrome (METS), a proatherogenic entity, [...]

Current study results from the report, 'A flow cytometry-based strategy to identify and express IgM from VH1-69+ clonal peripheral B cells,' have been published. According to recent research published in [...]

Investigators publish new data in the report 'A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation.' According to recent research from the United States, 'IDH1 (isocitrate dehydrogenase [...]

Research findings, 'Immunohistochemical detection of ZAP70 in chronic lymphocytic leukemia predicts immunoglobulin heavy chain gene mutation status and time to progression,' are discussed in a new report. 'Zeta-associated protein-70 (ZAP70) [...]

Research findings, 'IgM multiple myeloma: disease definition, prognosis, and differentiation from Waldenstrom's macroglobulinemia,' are discussed in a new report. According to recent research from the United States, 'IgM multiple myeloma [...]

Investigators publish new data in the report 'Morphological progression of myelin abnormalities in IgM-monoclonal gammopathy of undetermined significance anti-myelin-associated glycoprotein neuropathy.' According to a study from Nagoya, Japan, 'To characterize [...]

New research, 'Highly sensitive recombinant antibodies capable of reliably differentiating heart-type fatty acid binding protein from noncardiac isoforms,' is the subject of a report. 'During recent times, heart-type fatty acid [...]

New investigation results, 'DH and JH usage in murine fetal liver mirrors that of human fetal liver,' are detailed in a study published in Immunogenetics. 'In mouse and human, the [...]

Research findings, 'Combination of an aptamer probe to CD4 and antibodies for multicolored cell phenotyping,' are discussed in a new report. 'Aptamers have emerged as a new class of small [...]

Current study results from the report, 'The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms,' have [...]

New research, 'Production of anti-carbohydrate antibodies by phage display technologies: potential impairment of cell growth as a result of endogenous expression,' is the subject of a report. 'Anti-mannotriose (Man3) antibodies [...]

Research findings, 'Novel monoclonal antibodies against the proximal (carboxy-terminal) portions of MUC16,' are discussed in a new report. According to recent research published in the journal Applied Immunohistochemistry & Molecular [...]

Research findings, 'Long-term follow-up of monoclonal B-cell lymphocytosis detected in environmental health studies,' are discussed in a new report. According to recent research published in the journal Cytometry Part B, [...]

Fresh data on headache are presented in the report 'Not all intravenous immunoglobulin preparations are equally well tolerated.' According to recent research from Switzerland, 'Intravenous immunoglobulin (IVIG) is used for [...]

According to a study from the United States, 'Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality. Blood centers are implementing TRALI risk reduction strategies based on [...]

A new study, 'Hormonal replacement therapy may reduce the risk for RA in women with early arthritis who carry HLA-DRB1 *01 and/or *04 alleles by protecting against the production of [...]

Scientists discuss in 'Sequencing and quantifying IgG fragments and antigen-binding regions by mass spectrometry' new findings in proteins. 'In cancer and autoimmune diseases, immunoglobulins with a specific molecular signature that [...]

Investigators publish new data in the report 'Altered modulation of WNT-beta-catenin and PI3K/Akt pathways in IgA nephropathy.' According to recent research from Bari, Italy, 'Immunoglobulin A nephropathy (IgAN) is the [...]

Current study results from the report, 'Serum immunoglobulins in non-Hodgkin's lymphoma patients,' have been published. 'Serum proteins and immunoglobulin (Ig) findings in 119 non-Hodgkin's lymphoma (NHL) patients were analysed. Out [...]

Scientists discuss in 'Vkappa polymorphisms in NOD mice are spread throughout the entire immunoglobulin kappa locus and are shared by other autoimmune strains' new findings in serum globulins. 'The diversity [...]

Current study results from the report, 'Heparin-platelet factor 4 antibodies in intensive care patients: an observational seroprevalence study,' have been published. According to a study from the United States, 'Heparin-platelet [...]

Scientists discuss in 'Analytical and clinical performance of a new, automated assay panel for the diagnosis of antiphospholipid syndrome' new findings in antiphospholipid syndrome. 'Anticardiolipin (aCL) and anti-beta(2)glycoprotein I (abeta(2)GPI) [...]

Scientists discuss in 'Carrier induced epitopic suppression of antibody responses induced by virus-like particles is a dynamic phenomenon caused by carrier-specific antibodies' new findings in immunoglobulins. 'Pre-existing immunity against vaccine [...]

Data detailed in 'AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance' have been presented. 'Antibodies to aquaporin-4 (also known as AQP4-Ab or NMO-IgG) are sensitive and highly specific serum [...]

'The purpose of this study was to evaluate the influence of plasmapheresis on sleep in patients with generalized myasthenia gravis and no respiratory symptoms. Seven myasthenia gravis patients, four women [...]

Current study results from the report, 'Reactivity of a humanized antibody (hPankoMab) towards a tumor-related MUC1 epitope (TA-MUC1) with various human carcinomas,' have been published. 'Humanized antibodies against tumor-related antigens [...]

New research, 'Reduction of free immunoglobulin light chains using adsorption properties of hemodiafiltration with endogenous reinfusion,' is the subject of a report. 'In this work we investigated the acute effects [...]

'Vaginolysin (VLY) is a protein toxin released by Gardnerella vaginalis. VLY belongs to the group of cholesterol-dependent cytolysins (CDCs),' researchers in Vilnius, Lithuania report (see also Immunoglobulins). 'We have generated [...]