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One hundred and thirty-one structurally different placentas during multifoetal pregnancy have been studied by the morphohistochemical and morphological methods. A high degree of conservation of placenta tissue structures of twins is observed in clinically normal pregnancy; the disorganisation is very mild, and the whole tissue, especially the margin, is actively included in the compensatory-adaptive processes. During clinically complicated pregnancy combined with congenital defects of the foetus and placenta, reorganization of the functional morphology of the placenta of twins occurs, which has a dynamic character reflecting the degree of disorganization o the structural elements, and also the level of the development of compensatory-adaptive processes. The knowledge of these changes allows an evaluation with a high degree of significance of the functional ability of the twins placenta as an organ in which metabolic processes between mother and child take place.

The placenta was studied in 70 women: 19 of them had physiological pregnancy and 51 had pregnancy complicated with late toxicosis. Lesions in the placenta have been shown to increase with the growing severity of toxicosis, and compensatory potencies--to decrease. In late toxicosis the expansion of desorganization and reparation in the placenta occurs from the center towards periphery, the peripheral parts playing the role of reserved zones of the placenta, keeping high functional activity.

With the aim to use a previously elaborated method of extracorporeal fertilization of human ova for treating sterility, resulted from obstruction or absence of the uterine tubes, ova were obtained at laparoscopy after a previous hormonal stimulation of women. From 119 women 159 ova were obtained. Fertilization of the ova was performed in the medium Ham F-10 previously capacitated with the husband's spermatozoa. Fertilization rate was 66%. Embryos at the stage of 2-8 blastomeres were implanted transcervically into the uterine cavity with a special catheter. The embryo transfer was performed in 37 women with tubular infecundity. Menoschesis up to 3 weeks was noted in 5 women. In one woman on the 35th day after implantation, by means of hormonal-biological reaction and ultrasound investigation, pregnancy was diagnosed, it terminated in timely birth of a boy with body mass 3,500 gr. A conclusion was made that the main cause of failures at the embryo transfer was an inadequate preparation of the uterine mucosa (resulted from the main disease) to accept the fertilized ovum.