201. [Effects of pancreatic polypeptide amylin on ulceration and acid gastric secretion].
- Author
-
German SV, Kuper GJ, Kopylova GN, Samonina GE, Vorozheĭkina GV, Bakaeva ZV, and Platonova RD
- Subjects
- Animals, Disease Models, Animal, Gastric Mucosa metabolism, Hydrogen-Ion Concentration, Islet Amyloid Polypeptide, Rats, Stomach Ulcer metabolism, Amyloid pharmacology, Anti-Ulcer Agents pharmacology, Gastric Acid metabolism, Gastric Mucosa drug effects, Stomach Ulcer drug therapy
- Abstract
The effects of the pancreatic polypeptide amyline on ulceration and acid gastric secretion were studied in rat experiments. Pyloric ligation was used as a model of ulceration. Amyline administration caused significantly less gastric mucosal damage in response to pyloric ligation. The severity of gastric mucosal damage averaged 47 +/- 13 mm2 in the control group and 25 +/- 11 mm2 (p < 0.005). The rate of acid gastric secretion in the animals whose pylorus had been ligated as judged by the pH of gastric content was significantly higher than that in the controls (2.87 +/- 0.22 and 2.34 +/- 0.17 (p = 0.05). It is concluded that amyline has a noticeable effect on the gastric mucosa. It is suggested that suppressed acid gastric secretion, i.e. reduced influence of aggressive agents on the gastric mucosa, is a mechanism of antiulcerative action of the peptide.
- Published
- 1998