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Copyright of Medycyna Pracy is the property of Instytut Medycyny Pracy im. Jerzego Nofera and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Medycyna Pracy is the property of Instytut Medycyny Pracy im. Jerzego Nofera and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Medycyna Pracy is the property of Instytut Medycyny Pracy im. Jerzego Nofera and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objectives: Mechanisms of the vascular effect of cadmium vary and involve nervous, hormone and intracellular signaling pathways. However, it is still not clear if mechanisms of the vascular effect of cadmium (Cd) include changes in the synthesis or release of vasoactive agents. The aim of this study was to evaluate the impact of subchronic Cd poisoning on blood nitric oxide or endothelin in blood and to relate it to the redox system activity in vessel walls and to blood Cd concentration. Materials and Methods: The study was performed on male Buffalo rats which were given cadmium in drinking water, 50 or 200 ppm, for 12 weeks. Results: The study showed different dose-dependent changes in toxicological and biochemical status. Mean serum nitric oxide concentration (measured using R&D Systems) was lower in rats poisoned with cadmium compared with the control group (57.7 ± 7.6 vs..control 65.0 ± 4.9 µmol/l, p < 0.05), whereas the plasma endothelin-1 level (measured using enzymoimmunoassay) and serum prostaglandin PGF2a concentration (determined using R&D System) were similar in all animals. The lipid peroxides concentration (measured colorimetrically) was higher in the group treated with cadmium in a dose of 50 ppm than in controls (5.2 ± 3.0 vs. controls 1.4 ± 0.4 nmol//ml, p < 0.001) and gluthatione concentration was decreased in the group treated with cadmium in a dose of 200 ppm as compared with the control group, (1.3 ± 1.2 vs. control 2.5 ± 0.9 µmol/l p < 0.05). Conclusions: It is concluded, that cadmium induces oxidative stress in both doses, however, the activity of defending mechanisms depends on Cd dose. Oxidative stress can be responsible for decreased nitric oxide concentration in serum. We suppose that the mechanisms of the vascular effect of cadmium vary and are dose-dependent. Cd used in a dose of 50 ppm for three months induces more severe functional vascular disturbanc... [ABSTRACT FROM AUTHOR]

Background and objectives: Renalase, a novel amine oxidase, is involved in the development of hypertension. Sleep bruxism (SB) is a sleep-related behavior characterized by rhythmic or non-rhythmic activity of the masticatory muscles, which leads to the mechanical wear of teeth, pain in the masticatory muscles, and disturbed sleep. Recent studies indicate that SB plays a role in increased blood pressure. Therefore, this study aimed to determine the relationship between sleep bruxism intensity and renalase concentration, which may help in the future to elucidate the pathogenesis of hypertension and other cardiovascular disorders. Material and methods: SB was evaluated in 87 adult patients using single-night diagnostic polysomnography with video and audio recordings, and the episodes of bruxism were scored according to the standards of the American Academy of Sleep Medicine. The levels of serum renalase were measured in the patients using enzyme-linked immunosorbent assay kits. Results: SB (Bruxism Episode Index (BEI) ≥2) was diagnosed in 54% (n = 47) of the studied population, and the mean concentration of renalase was found to be decreased in the hypertensive group compared with the normotensive group (133.33 ± 160.71 vs 219.23 ± 220.58, p = 0.047). In addition, a linear negative correlation was observed between the renalase concentration and the body mass index (BMI) in the SB group (r = 0.38, p < 0.05) but not in controls. Thus, higher BEI and higher BMI were identified as factors independently associated with the lower concentration of renalase, but only in the group of patients which had a blood renalase concentration of >212.5 ng/mL. Conclusion: There exists an association between renalase concentration and SB intensity, and further studies are needed to clarify the role of renalase in the pathogenesis of hypertension and other cardiovascular disorders. [ABSTRACT FROM AUTHOR]

Obstructive sleep apnea (OSA) causes dysfunction of the autonomic nervous system, but the exact mechanism has not been fully understood. The aim of this study was to analyse the relationship between the incidence and severity of OSA and heart rate turbulence (HRT). Seventy one patients with clinical suspicion of OSA were qualified to participate in the study. All participants took part in a survey and were subjected to laboratory tests, 24-hour electrocardiogram (ECG) Holter monitoring with HRT analysis and polysomnography. The group with OSA manifested significantly higher turbulence onset (TO) and lower turbulence slope (TS) as compared to the group without OSA. Older age, diabetes, hypertension and higher apnea/hypopnea index (AHI) were found to be independent risk factors for increased TO, whereas older age, higher body mass index (BMI), higher blood glucose levels, hypertension and higher AHI were independent risk factors for TS reduction. The AHI ≥65 criterion indicates abnormal HRT in patients with OSA with 94.9% sensitivity and 50.0% specificity, which gives a prediction accuracy of 85.7%. In summary, OSA should be considered as a predictor of abnormal HRT. [ABSTRACT FROM AUTHOR]

In this comment, we explored the link between sleep fragmentation and the cardiovascular risk, considering various sleep disorders and methodologies for assessing sleep fragmentation.

Background: Tension-type headache (TTH) is the most common primary headache. Obstructive sleep apnea (OSA) and sleep bruxism (SB) are two of the most common sleep disorders; however, the relationship between TTH, OSA, and SB has not been conclusively proved in the literature. The objective of our study was to estimate potential associations with OSA and SB in TTH subjects. Methods : 108 adult individuals who underwent polysomnography (vPSG) were included, and the group was divided into two subgroups: TTH ( n = 34) and control ( n = 74). The International Classification of Headache Disorders (ICHD-3) guidelines were used to diagnose TTH. OSA and SB diagnoses were based on vPSG examination with electromyographic (EMG) recordings and the American Academy of Sleep Medicine (AASM) criteria. The results were analyzed, where p < 0.05 was considered to be statistically significant. Results : In the TTH group, the incidence of SB was more than two times lower than the control (OR = 0.41, 95% CI: 0.17-0.96, p < 0.05). However, the incidence of severe SB (BEI > 4) was similar in the TTH and control groups (OR = 0.54, 95% CI: 0.21-1.35, p > 0.05). Additionally, phasic and tonic SB episodes were less frequent in the TTH group compared to the controls ( p < 0.05). The mean apnea-hypopnea index (AHI) was not significantly different between the TTH and control groups ( p > 0.05). The sleep architecture and respiratory disturbances did not differ between the examined groups ( p > 0.05). Conclusions : SB is not a risk factor for TTH. Moreover, severe SB is not connected with TTH. OSA is not a risk factor for TTH. Sleep quality did not differ between both groups during PSG; therefore, TTH may not change sleep structure. The mechanism of these findings is still unclear, and further studies should explain in detail the association between TTH and OSA.

Background: Obstructive sleep apnea (OSA) and arterial hypertension (AH) are closely linked disorders with common pathophysiological features., Objectives: The present study aimed to investigate the relationship between AH and OSA by examining sleep architecture, vitamin D concentration and electrolyte levels in patients with these coexisting conditions., Material and Methods: A total of 133 patients suspected of having OSA were recruited for examination. The participants were divided into 2 groups: hypertensives (n = 52); and normotensives (n = 81). One full-night polysomnographic examinations were conducted, followed by the statistical analysis of the collected data., Results: Hypertensive individuals displayed increased apnea-hypopnea index (AHI), oxygen desaturation index (ODI), respiratory arousal index (RAI), and periodic limb movement index (PLMI) as compared to non-hypertensive individuals. Moreover, sleep efficiency (SE), the bruxism arousal index (BAI) and oxygen saturation (SpO2) level were decreased in the hypertensive group. In terms of biochemical parameters, hypertensive individuals exhibited a lower magnesium (Mg) level, and higher levels of C-reactive protein (CRP), uric acid (UA) and glucose. Notably, there were no statistical differences in vitamin D concentration between hypertensive and normotensive individuals., Conclusions: The study explored the potential influence of calcium (Ca), Mg, vitamin D, and UA concentrations on the sleep architecture of patients with comorbid AH and OSA. The findings revealed several notable associations. Firstly, sleep fragmentation correlated with Ca level, suggesting a potential role for both Ca and vitamin D in sleep arousals. Secondly, a higher UA concentration was linked to a higher AHI and increased sleep fragmentation. Additionally, alterations in Mg concentration were observed among hypertensive individuals with OSA. However, further research is needed to fully comprehend the potential impact of these factors on the sleep architecture of hypertensive individuals with apnea.

Background/aim: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) production and a newly discovered risk factor involved in endothelial dysfunction and adverse cardiovascular events. Recently, both NO and ADMA have also emerged as molecules of interest in carcinogenesis and tumor growth progression. Our earlier studies have confirmed elevated plasma ADMA levels in patients with hematological malignancies. However, the cause of elevated ADMA was unclear. The aim of this study was to assess the concentrations of ADMA, symmetric dimethylarginine (SDMA) and L-arginine in rats exposed to N-nitroso-N-methylurea (NMU) for the induction of mammary tumors., Materials and Methods: A total of 95 female rats of the Sprague-Dawley strain were used in the study. Plasma concentrations of ADMA, SDMA and L-arginine were quantified and statistically analyzed., Results: Mean ADMA levels were higher in the tumor-bearing group compared to the control group. Mean plasma levels of SDMA and L-Arginine were not significantly different between the groups. The L-ARG/ADMA ratio was lower in rats with tumors compared to controls., Conclusion: Histological assessment confirmed expression of ADMA within the tumor cells, which strongly suggests that these tumor cells were the source of ADMA. Other studies are warranted to further explain the role of ADMA in neoplastic diseases., (Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Objective : To evaluate the correlation between the Bruxism Episodes Index (BEI) that determines the number of bruxism episodes per hour of sleep and sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI). Methods : Seventy-seven participants (56 women and 21 men) in which probable sleep bruxism was diagnosed using guidelines of the American Academy of Sleep Medicine underwent video-polysomnography. Sleep quality was measured using PSQI. Results : The analysis showed the lack of a statistically significant correlation between the BEI and PSQI scores ( p = 0.55). Analysis also showed that the study group (bruxers) and control group (non-bruxers) did not differ significantly in terms of PSQI scores ( p = 0.88). Conclusion : The intensity of bruxism seems not to affect the quality of sleep. However, the topic of the relationship between sleep quality and the occurrence of sleep bruxism requires further research, taking into account co-occurring sleep disorders and sleep architecture.

Objective: The aim of this cohort study was to evaluate the prevalence of hypertension and cardiovascular risk factors in the studied population., Methods: Presented results are a part of the Polish-Norwegian Study (PONS) project. The study group consisted of 3,862 inhabitants of Świętokrzyskie Province aged 45-64 years (2,572 females and 1,290 males)., Results: Prevalence, awareness and control of hypertension was evaluated in the studied population of 3,854 urban and rural inhabitants. Mean blood pressure in the whole studied population was 139.6/81.9 mmHg; of the studied population 61.7% were hypertensive. Hypertension was more prevalent in the studied males (70.63%) than in the females (57.24%). In both males and females, the older subgroups (55-64 y.o.) had significantly higher blood pressure than the younger subgroups (45-54). Education had a significant impact on the prevalence of hypertension, and the highest prevalence of hypertension was observed in the middle level educated groups of females and males. No significant difference was observed between rural and urban inhabitants. In both females and males, the prevalence of hypertension significantly decreased with level of education. Hypertension was well-controlled in only 13.8% of the subjects. More studied females than males achieved good control of blood pressure (14.09 vs. 12.7%), and better control of blood pressure was significantly more frequent in better those who were better educated. Hypertension was not diagnosed in 23.2% of studied population. Significantly, more males than females had undiagnosed hypertension (30.4 vs. 19.5%). No significant difference between rural and urban populations was observed. Interestingly, both in females and males, the better educated groups had more undiagnosed hypertension than those who were well-educated., Conclusions: The studied group had a high prevalence of hypertension (61.7%), which was less frequent and better controlled in the studied females than in the males. No significant difference was observed between the urban and rural populations. Level of education had significant impact on the prevalence of hypertension.

The study was aimed, therefore, at investigating eating habits of patients with diagnosed arterial hypertension of the Clinic of Occupational Diseases and Arterial Hypertension, Clinical Hospital of the Medical Academy in Wrocław. It covered 52 persons with diagnosed arterial hypertension--patients of the Clinic of Occupational Diseases and Arterial Hypertension, Clinical Hospital of the Medical Academy in Wrocław. Evaluation of their eating habits was conducted with the use of an original, standardized questionnaire elaborated at the Chair of Human Nutrition, Wrocław University of Environmental and Life Sciences. Amongst examined patients 12.9% of men and 33.3% of women were eating 4 meals, 5 meals--5% of women and 3% of men, and more than 5 meals--3.2% of men. It was demonstrated that the majority of sick persons have eaten the white wheat bread. It concerned over 33% women and 58% men. Close 29% patients vegetables were found in a diet in 3 portions, at 14% of them--in 4 portions, however almost 10% ill women ate 5 portions of vegetables mane. About 38% women provided with only 2 portions of vegetables per day, and 10%--only one. The appropriate supply of fruits realized 81% of women and 78% of men. Irregular consumptions of the milk and dairy products declared 67% women and 48% men. It is recommended the alteration of the warehouse of the nutritional rations ill from the arterial hypertension consists for increasing cereals in the diet of the participation of solid meal, leguminous seeds, vegetables and fruits and reducing the share of animal fats.

Background: Cardiovascular diseases, including hypertension, are a leading cause of death in developing and developed countries. Mercury can induce hypertension and atherosclerosis in experimental animals and humans. The assessment of the effect of mercury on the occurrence of cardiovascular system disturbances in the population is an essential task. The aim of this study was to assess the association between mercury concentration in urine and the risk of fatal cardiovascular disease during ten coming years., Material and Methods: The study included chemical factory workers who used mercury in the chlorine production., Results: The mean urine concentration of mercury in 154 workers was 4.9 +/- 11.2 microg/g creatinine. The most common disease was hypertension., Conclusions: The cardiovascular risk was higher in workers exposed to small or moderate mercury levels than in workers exposed to mercury vapor in high concentrations. Furthermore, the negative association was observed between mercury exposure and smoking in workers with low urinary excretion of mercury.

The deterioration of male fertility, reported in numerous epidemiological studies over past decades, can be connected with growing exposure to environmental toxins. Heavy metals, especially cadmium, is widely spread and extremely toxic. The mechanisms of cadmium toxic effects vary and involve the damage of vascular endothelium, intracellular junctions, germ cells, Leydig and Sertoli cells. Cadmium can increase activity of reactive oxygen species and induce changes in activity of enzymatic systems and inflammatory reactions. The morphological changes caused by cadmium included the necrosis of seminiferous tubiles and interstitial edema. This metal can reduce testosterone synthesis at various levels and deteriorate spermatogenesis. Cadmium is also acknowledged carcinogen with confirmed mutagenic and genotoxic activity. Increasing environmental exposure to cadmium, currently existing occupational exposure and the prevalence of tobacco smoking results in constant increase in the number of diagnosed fertility impairments.