Search

In March 1945 Clement and Godlewski 1 reported a case of agranulocytosis in a girl 13 1/2 years of age with asthma after she received three weeks of treatment with a synthetic anti-histaminic agent 2339 RP (N-benzyl-N-phenyl-N',N'-dimethylethylenediamine hydrochloride). Blanton and Owens 2 have reported a similar case following eight weeks of therapy with tripelennamine hydrochloride (pyribenzamine hydrochloride,® or N,N-dimethyl-N'-benzyl-N'-[alpha-pyridyl] ethylenediamine hydrochloride). The present report concerns the occurrence of agranulocytosis in a man aged 81 after he received seven weeks of treatment with methaphenilene hydrochloride (diatrin hydrochloride,® or N,N-dimethyl-N'-phenyl-N'-[2-thenyl] ethylenediamine hydrochloride)—a homolog of tripelennamine hydrochloride. REPORT OF CASE J. M., a man aged 81; a retired grocer, had been seen intermittently since May 21, 1946 because of chronic bronchitis. The nasal mucosa was hypertrophic and varied from a pale boggy appearance to a dull red. Polyps nearly blocked the left nasal fossa, and at times yellowish mucopurulent drainage could be seen

N. A. W., a colored man, aged 34, a native of the British West Indies, came to the West Side Dispensary, Jan. 17, 1920, with a history of yellow discharge from the right nostril during the previous two months. Examination revealed a large black mass in the right nasal fossa, very firm and hard, but freely movable in its bed. The septum was pushed over to the left, and the mass was bathed in yellow pus. It seemed reasonable to suppose that we had to do with a mass of necrotic bone, probably a sequestrum from the nasoantral wall following a tertiary lesion. Pledgets of cotton saturated with 10 per cent. cocain were introduced into the nose and left for ten minutes, at the end of which time our diagnostic acumen received a rude shock. When 17 years of age, the patient tried to invent a gun. He took a

The genus Witaaspis was erected in 1939 for Pander's Cephalaspis schrenckii (1). In the list of genera and species given in 1939 (2) for the Oesel horizon I listed a second species of Witaaspis. This species, Witaaspis patteni, occurs in the same quarry with Witaaspis schrenckii. Both species are of similar size and body form, but the ornamentation and the form of the median dorsal crista differ sufficiently to make them readily recognizable. Witaaspis patteni is a small form, with a shield length about 17mm., and a breadth of about 20mm. The cornua are rudimentary as in Witaaspis schrenckii. The posterior portion of the shield shows slight segmentation traces. A pronounced median dorsal crista is apparent on most specimens, ending in a median posterior projection which appears to be composed of massed spines or tubercles. The crista is low on Witaaspis schrenckii. The lateral fields are long, ending in front of the cornua. The dorsal field is short, posteriorly truncated, and the endolymphatic apertures are located posterolateral to it. Ridges bound the field laterally. The nasal aperture is long and is located on a slight ridge in the fossa. Its anterior end is wider than its posterior end. The orbits are about 2.5 mm. by 2 mm., and are oval in form. The ornamentation consists of fine tubercles or striae with no separation into fields as in Witaaspis schrenckii. Within the marginal area the tubercles are heavier and massed together. The infraorbital sensory canal is similar to that in Witaaspis schrenckii, but turns medially more abruptly anterior to the nasal fossa.

The true mucous adenoma in the nasal fossa, while not a rare tumor, is a relatively uncommon one. References to it in the American literature are scarce and somewhat sketchy; hence, it is felt that the report of this case is of some value to those pursuing the study of this entity along further lines. The exact classification and behavior of this tumor seems fraught with confusion, apparently because of its being mistaken for other tumefactions containing mucous glands which occur in the nose and paranasal sinuses. Most authors 1,2,4,7 classify it as a benign neoplasm on the basis of its histological behavior but malignant on the basis of its clinical behavior. Natanson 6 classifies the adenoma into two categories, the benign, or true, adenoma, and the malignant, or destructive, adenoma. The first class he describes as being small, encapsulated, and arising most commonly on the tuberculum septi but seen

Tumors of the nasal fossa apparently related in origin to the olfactory area have been neglected by American pathologists, although several reports of their occurrence can be found in the European literature. Berger, Luc, and Richard 1 first recognized such a tumor in 1924 and reported it as an "esthesioneuroepitheliome olfactif"; the neoplasm occurred in an elderly man and was characterized by cells possessing true fibrils and forming rosets. Two years later Berger and Coutard 2 published a report on a similar tumor, which they diagnosed as an "esthesioneurocytome olfactif"; this lesion occurred in a 32-year-old woman with a 20-year clinical course and was characterized by cells that possessed only the ability to form fibrils. The authors considered it a more mature type of neoplasm in the same general group as the one reported on by Berger and co-workers. Schall and Lineback 3 recently reviewed the literature and collected accounts