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971 results on '"Rose, Sarah"'

302. Screen grabbers

Author

Rose, Sarah

Subjects
Online dating, Dating services
Abstract

Want to up your score with online dating? Swipe the slate clean-and meet the nicest girls--by following these tips. The greatest invention in romance since condoms, dating apps are pure [...]

Published
2017

303. The morning after

Author

Rose, Sarah

Subjects
Methods, Female-male relations, Dating (Social customs) -- Methods
Abstract

You spent a glorious night (or not) together. Now, how do you get out alive? * It's the morning after the night before. You're waking up beside her for the [...]

Published
2016

304. Should you bring her to the wedding?

Author

Rose, Sarah

Subjects
Weddings
Abstract

Watching a buddy get hitched can be a fun, happy time or-with a girlfriend as your 'plus-one'-a shrapnel--dodging crawl through relationship hell. Take your pick. It's high season for happily [...]

Published
2016

307. Patient satisfaction and regret with decision differ between outcomes in the composite definition of success after reconstructive surgery.

Author

Khoder, Waseem, Hom, Emily, Guanzon, Anna, Rose, Sarah, Hale, Douglass, and Heit, Michael

Subjects
PELVIC organ prolapse, PLASTIC surgery, PATIENT satisfaction, LAPAROSCOPIC surgery, URINARY incontinence, PATIENTS
Abstract

Introduction and hypothesis: To evaluate patient satisfaction and regret with their decision for reconstructive surgery, and determine if they valued each item equally in the composite definition of success after making the decision for surgery. Methods: A list was created including all patients who underwent laparoscopic sacral colpopexy or laparoscopic uterosacrocolpopexy. Patients were placed in mutually exclusive outcome categories (retreatment, symptomatic failure, anatomic failure, and surgical success). Retreatment included any postoperative treatment for urinary incontinence, pelvic organ prolapse including pessary use, or surgery for mesh complications. The validated modified Decision Regret Scale (DRS) and the Satisfaction Decision Scale (SDS) questionnaires were administered by telephone. Higher DRS scores indicate greater regret and higher SDS scores indicate greater satisfaction with the decision for surgery. Results: Of 715 patients, 197 were successfully contacted by telephone following reconstructive surgery and surveyed as study participants. Composite surgical outcomes were available for 150. Information on the need for retreatment was available for all the study participants. Surgery was successful in 101 (67.3 %) of the study participants. Anatomic failure occurred in 14, symptomatic failure occurred in 10, and retreatment was required in 25 of the study participants. Overall, the study participants were more satisfied than regretful with their decision for reconstructive surgery. Regret and satisfaction with their decision differed between outcomes in the composite definition of success after reconstructive surgery. Conclusions: Surgeons and patients should focus on retreatment rates during preoperative outcome discussions because retreatment will result in the least satisfaction and greatest regret with the decision for reconstructive surgery. [ABSTRACT FROM AUTHOR]

Published
2017
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310. Life Defeat Scale

Author

Sturman, Edward D., primary, Rose, Sarah, additional, McKeighan, Kylie M., additional, Burch, Jennifer, additional, and Evanico, Kate, additional

Published
2015
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311. The H3 receptor agonist immepip does not affect l-dopa-induced abnormal involuntary movements in 6-OHDA-lesioned rats

Author

Papathanou, Maria, Jenner, Peter, Iravani, Mahmoud, Jackson, Michael, Stockwell, Kim, Strang, Isabel, Zeng, Bai-Yun, McCreary, Andrew C, Rose, Sarah, Papathanou, Maria, Jenner, Peter, Iravani, Mahmoud, Jackson, Michael, Stockwell, Kim, Strang, Isabel, Zeng, Bai-Yun, McCreary, Andrew C, and Rose, Sarah

Abstract

The treatment of dyskinesia in Parkinson׳s disease remains poor but H3 receptor agonists have been suggested as a novel pharmacological approach. We examined the effects of the H3 agonist, immepip, in 6-OHDA-lesioned rats exhibiting AIMs (abnormal involuntary movements), a rat analogue of dyskinesia, in response to l-dopa compared to the known anti-dyskinetic agents amantadine, MK-801 and 8-OHDPAT. We then attempted to extend these studies in to dyskinetic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated common marmosets. Amantadine, MK-801 and 8-OHDPAT all dose-dependently reduced l-dopa-induced axial, lingual and oral (ALO) AIMs in 6-OHDA-lesioned animals accompanied by a reduction in contralateral rotation with higher doses of amantadine and MK-801. By contrast, immepip had no effect on AIMs expression or contralateral rotation. In the MPTP-treated common marmoset exhibiting dyskinesia to l-dopa, immepip alone induced retching and in combination with l-dopa administered subcutaneously or orally induced the rapid onset of retching and vomiting which was not controlled by pretreatment with domperidone. Administration of the unrelated H3 agonist, imetit had the same effect. Despite causing negative side-effects, it appears that both agonists reduced the antiparkinsonian response to l-dopa resulting in reduced dyskinesia. H3 agonists appear unlikely candidates for the treatment of dyskinesia in PD based on lack of evidence of efficacy and potential adverse effects.

Published
2014
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322. Score a V-Day victory

Author

Rose, Sarah

Subjects
Methods, Female-male relations -- Methods, Dating (Social customs) -- Methods
Abstract

Been dating a few weeks? A while? Forever? The right Valentine's Day gift at the right time can yield dividends right where it counts. Yes, women are slaves to the [...]

Published
2016

323. Diagnosing Coeliac Disease: A Patient's Journey and the Future of Testing

Author

Rose, Sarah and Rose, Sarah

Abstract

We report a one and half year old male child diagnosed with Wiskott - Aldrich syndrome (WAS). He had persistent thrombocytopenia which on bone marrow biopsy was found to be macrothrombocytopenia. He did not exhibit any characteristic clinical and laboratory findings indicating the syndrome. A test for WASp gene was done which showed reduced expression. Thus it is essential to test for mutations of the WAS gene in all unexplained cases of infantile thrombocytopenia even in the absence of characteristic feature of microthrombocytopenia.

Published
2013

331. Disability, Epistemology, Sciencing.

Author

Mills, Mara, Virdi, Jaipreet, and Rose, Sarah F.

Subjects
*THEORY of knowledge, *HISTORY of science, *SCIENTIFIC knowledge, *DISABILITIES, *TAYLORISM (Management)
Abstract

Disability has been a central—if unacknowledged—force in the history of science, as in the scientific disciplines. Across historical epistemology and laboratory research, disability has been "good to think with": an object of investigation made to yield generalizable truths. Yet disability is rarely imagined to be the source of expertise, especially the kind of expertise that produces scientific knowledge. The introduction to this volume of Osiris announces a disability history of science, placing disability history and the history of science in conversation to foreground disability epistemologies, disabled scientists, and disability sciencing (engagement with scientific tools and processes). Looking beyond the paradigms of medicalization and industrialization, we further propose a scientific management model of disability to account for the shaping of disabled lives and relations by the applied sciences, from the ancient world to the present. [ABSTRACT FROM AUTHOR]

Published
2024
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337. Defining Benchmarks for Adenoma Detection Rate and Adenomas Per Colonoscopy in Patients Undergoing Colonoscopy Due to a Positive Fecal Immunochemical Test

Author

Hilsden, Robert J, Bridges, Ronald, Dube, Catherine, McGregor, S Elizabeth, Naugler, Christopher, Rose, Sarah M, Rostom, Alaa, and Heitman, Steven J

Abstract

Objectives:Although there is an accepted benchmark for adenoma detection rate (ADR) in average risk screening colonoscopy, a benchmark for ADR or the associated quality indicator, adenomas per colonoscopy (APC), for colonoscopies performed for a positive fecal immunochemical test (FIT+) has not been established. The purpose of this study was to propose methods for establishing a benchmark ADR and APC for FIT+ patients.Methods:In this historical cohort study, we included 15,329 patients aged 50–74 years who underwent a colonoscopy at Alberta Health Services’ Colon Cancer Screening Centre, Calgary, Canada, from 1 January 2014 to 30 June 2015 for either investigation of a positive FIT or average risk screening. Using meta-regression, we estimated for FIT+ patients the ADR and APC that corresponded to (Method #1: minimally acceptable) an ADR of 25% in average risk individuals, (Method #2: standard of care) the average ADR or APC in all FIT+ patients, and (Method #3: aspirational) the average FIT+ ADR or APC in colonoscopies performed by endoscopists with an ADR of ≥35% in average risk patients.Results:At least one adenoma was detected in 30% of average risk patients and 58% of FIT+ patients. The calculated benchmark FIT+ ADRs for the three methods were 55, 60, and 65%, respectively. The calculated benchmarks for FIT+ APC were 1.2, 1.4, and 1.7, respectively. To account for expected random variation in individual endoscopists’ ADR or APC, we propose using the upper bound of the 95% confidence interval of an endoscopist’s ADR or APC to determine if they fall below a given benchmark.Conclusions:We have proposed methods of defining benchmarks for ADR and APC in FIT+ patients that go beyond the current “minimally acceptable” threshold currently recommended in average risk patients. These new thresholds represent results obtained by all peers and by a group of expert adenoma detectors defined in an independent patient cohort (average risk). Because the true adenoma burden in FIT+ patients could vary based on factors such as the threshold used to define a positive FIT, screening programs or endoscopy units may need to calculate their own benchmarks using local data.

Published
2017
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347. The arylation of [Pt2(μ-S)2(PPh3)4]

Author

Deadman, Benjamin J., primary, Henderson, William, additional, Nicholson, Brian K., additional, Petchell, Laura E., additional, Rose, Sarah L., additional, and Hor, T.S. Andy, additional

Published
2010
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