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306. Neuronavigated Magnetic Stimulation combined with cognitive training for Alzheimer's patients: an EEG graph study.

Author

Vecchio, Fabrizio, Quaranta, Davide, Miraglia, Francesca, Pappalettera, Chiara, Di Iorio, Riccardo, L'Abbate, Federica, Cotelli, Maria, Marra, Camillo, and Rossini, Paolo Maria

Subjects
ALZHEIMER'S patients, COGNITIVE training, TRANSCRANIAL magnetic stimulation, ELECTROENCEPHALOGRAPHY, SYNTAX (Grammar), READING comprehension
Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disorder in elderly subjects. Recent studies verified the effects of cognitive training combined with repetitive transcranial magnetic stimulation (rTMS-COG) in AD patients. Here, we analyzed neuropsychological and neurophysiological data, derived from electroencephalography (EEG), to evaluate the effects of a 6-week protocol of rTMS-COG in 72 AD. We designed a randomized, double-blind, sham-controlled trial to evaluate efficacy of rTMS on 6 brain regions obtained by an individual MRI combined with COG related to brain areas to stimulate (i.e., syntax and grammar tasks, comprehension of lexical meaning and categorization tasks, action naming, object naming, spatial memory, spatial attention). Patients underwent neuropsychological and EEG examination before (T0), after treatment (T1), and after 40 weeks (T2), to evaluate the effects of rehabilitation therapy. "Small World" (SW) graph approach was introduced allowing us to model the architecture of brain connectivity in order to correlate it with cognitive improvements. We found that following 6 weeks of intensive daily treatment the immediate results showed an improvement in cognitive scales among AD patients. SW present no differences before and after the treatment, whereas a crucial SW modulation emerges at 40-week follow-up, emphasizing the importance of rTMS-COG rehabilitation treatment for AD. Additional results demonstrated that the delta and alpha1 SW seem to be diagnostic biomarkers of AD, whereas alpha2 SW might represent a prognostic biomarker of cognitive recovery. Derived EEG parameters can be awarded the role of diagnostic and predictive biomarkers of AD progression, and rTMS-COG can be regarded as a potentially useful treatment for AD. [ABSTRACT FROM AUTHOR]

Published
2022
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307. BDNF Val66Met gene polymorphism modulates brain activity following rTMS-induced memory impairment.

Author

Abellaneda-Pérez, Kilian, Martin-Trias, Pablo, Cassé-Perrot, Catherine, Vaqué-Alcázar, Lídia, Lanteaume, Laura, Solana, Elisabeth, Babiloni, Claudio, Lizio, Roberta, Junqué, Carme, Bargalló, Núria, Rossini, Paolo Maria, Micallef, Joëlle, Truillet, Romain, Charles, Estelle, Jouve, Elisabeth, Bordet, Régis, Santamaria, Joan, Rossi, Simone, Pascual-Leone, Alvaro, and Blin, Olivier

Subjects
GENETIC polymorphisms, MEMORY disorders, BRAIN-derived neurotrophic factor, VISUAL memory, COGNITIVE ability
Abstract

The BDNF Val66Met gene polymorphism is a relevant factor explaining inter-individual differences to TMS responses in studies of the motor system. However, whether this variant also contributes to TMS-induced memory effects, as well as their underlying brain mechanisms, remains unexplored. In this investigation, we applied rTMS during encoding of a visual memory task either over the left frontal cortex (LFC; experimental condition) or the cranial vertex (control condition). Subsequently, individuals underwent a recognition memory phase during a functional MRI acquisition. We included 43 young volunteers and classified them as 19 Met allele carriers and 24 as Val/Val individuals. The results revealed that rTMS delivered over LFC compared to vertex stimulation resulted in reduced memory performance only amongst Val/Val allele carriers. This genetic group also exhibited greater fMRI brain activity during memory recognition, mainly over frontal regions, which was positively associated with cognitive performance. We concluded that BDNF Val66Met gene polymorphism, known to exert a significant effect on neuroplasticity, modulates the impact of rTMS both at the cognitive as well as at the associated brain networks expression levels. This data provides new insights on the brain mechanisms explaining cognitive inter-individual differences to TMS, and may inform future, more individually-tailored rTMS interventions. [ABSTRACT FROM AUTHOR]

Published
2022
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308. Brain Networks Modulation in Young and Old Subjects During Transcranial Direct Current Stimulation Applied on Prefrontal and Parietal Cortex.

Author

Miraglia, Francesca, Vecchio, Fabrizio, Pellicciari, Maria Concetta, Cespon, Jesus, and Rossini, Paolo Maria

Subjects
TRANSCRANIAL direct current stimulation, LARGE-scale brain networks, PARIETAL lobe, PREFRONTAL cortex, OLDER people, FUNCTIONAL connectivity
Abstract

Evidence indicates that the transcranial direct current stimulation (tDCS) has the potential to transiently modulate cognitive function, including age-related changes in brain performance. Only a small number of studies have explored the interaction between the stimulation sites on the scalp, task performance, and brain network connectivity within the frame of physiological aging. We aimed to evaluate the spread of brain activation in both young and older adults in response to anodal tDCS applied to two different scalp stimulation sites: Prefrontal cortex (PFC) and posterior parietal cortex (PPC). EEG data were recorded during tDCS stimulation and evaluated using the Small World (SW) index as a graph theory metric. Before and after tDCS, participants performed a behavioral task; a performance accuracy index was computed and correlated with the SW index. Results showed that the SW index increased during tDCS of the PPC compared to the PFC at higher EEG frequencies only in young participants. tDCS at the PPC site did not exert significant effects on the performance, while tDCS at the PFC site appeared to influence task reaction times in the same direction in both young and older participants. In conclusion, studies using tDCS to modulate functional connectivity and influence behavior can help identify suitable protocols for the aging brain. [ABSTRACT FROM AUTHOR]

Published
2022
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313. Brain network modulation in transradial amputee with finger perception restored through biomimetic intraneural stimulation.

Author

Vecchio, Fabrizio, Miraglia, Francesca, Alù, Francesca, Valle, Giacomo, Mazzoni, Alberto, Oddo, Calogero, Micera, Silvestro, and Rossini, Paolo Maria

Subjects
LARGE-scale brain networks, NEURAL stimulation, FINGERS, RADIAL artery, AMPUTEES, ARM amputation
Abstract

Introduction/aims: The hand is a sophisticated tool which allows humans to interact with the external world mainly via the sense of touch. Previous evidences demonstrated that electrical stimulations of the nerve trunks governing the hand are able to restore touch perception in transradial amputees. The aim of this study was to evaluate the neurological correlates of restored perception by the evaluation of network characteristics of the brain connectome via EEG recordings in amputees utilizing a fully sensorized bionic hand. Methods: A 48-year-old female with a left wrist traumatic disarticulation incurred 23 years prior to the study was enrolled for 6 months, during which experimental sessions were randomized. The control group included 12 healthy subjects performing a similar protocol. Results: Results showed that in both amputee and control group, a trend of SW in delta and beta 1 is recognizable (Delta and Beta 1 opposite spread) selectively in the hemisphere contralateral to the stimulus. Discussion: Delta increases (less orderly network) while Beta 1 decreases (more ordered network). It could be seen as a sign of higher attention and concentration of subjects to understand the perception and this monolateral modulation is similar to the bilateral attention given to the mathematical task difficulty's increment. [ABSTRACT FROM AUTHOR]

Published
2021
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321. Corticomotor Plasticity Predicts Clinical Efficacy of Combined Neuromodulation and Cognitive Training in Alzheimer’s Disease

Author

Brem, Anna-Katharine, primary, Di Iorio, Riccardo, additional, Fried, Peter J., additional, Oliveira-Maia, Albino J., additional, Marra, Camillo, additional, Profice, Paolo, additional, Quaranta, Davide, additional, Schilberg, Lukas, additional, Atkinson, Natasha J., additional, Seligson, Erica E., additional, Rossini, Paolo Maria, additional, and Pascual-Leone, Alvaro, additional

Published
2020
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322. Stability of flexible thin-film metallization stimulation electrodes: analysis of explants after first-in-human study and improvement of in vivo performance

Author

Čvančara, Paul, primary, Boretius, Tim, additional, López-Álvarez, Víctor M, additional, Maciejasz, Pawel, additional, Andreu, David, additional, Raspopovic, Stanisa, additional, Petrini, Francesco, additional, Micera, Silvestro, additional, Granata, Giuseppe, additional, Fernandez, Eduardo, additional, Rossini, Paolo M, additional, Yoshida, Ken, additional, Jensen, Winnie, additional, Divoux, Jean-Louis, additional, Guiraud, David, additional, Navarro, Xavier, additional, and Stieglitz, Thomas, additional

Published
2020
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324. Human brain connectivity: Clinical applications for clinical neurophysiology

Author

Hallett, Mark, primary, de Haan, Willem, additional, Deco, Gustavo, additional, Dengler, Reinhard, additional, Di Iorio, Riccardo, additional, Gallea, Cecile, additional, Gerloff, Christian, additional, Grefkes, Christian, additional, Helmich, Rick C., additional, Kringelbach, Morten L., additional, Miraglia, Francesca, additional, Rektor, Ivan, additional, Strýček, Ondřej, additional, Vecchio, Fabrizio, additional, Volz, Lukas J., additional, Wu, Tao, additional, and Rossini, Paolo M., additional

Published
2020
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327. CSF cutoffs for MCI due to AD depend on APOEε4 carrier status

Author

Marizzoni, Moira, primary, Ferrari, Clarissa, additional, Babiloni, Claudio, additional, Albani, Diego, additional, Barkhof, Frederik, additional, Cavaliere, Libera, additional, Didic, Mira, additional, Forloni, Gianluigi, additional, Fusco, Federica, additional, Galluzzi, Samantha, additional, Hensch, Tilman, additional, Jovicich, Jorge, additional, Marra, Camillo, additional, Molinuevo, José Luis, additional, Nobili, Flavio, additional, Parnetti, Lucilla, additional, Payoux, Pierre, additional, Ranjeva, Jean-Philippe, additional, Ribaldi, Federica, additional, Rolandi, Elena, additional, Rossini, Paolo Maria, additional, Salvatore, Marco, additional, Soricelli, Andrea, additional, Tsolaki, Magda, additional, Visser, Pieter Jelle, additional, Wiltfang, Jens, additional, Richardson, Jill C., additional, Bordet, Régis, additional, Blin, Olivier, additional, and Frisoni, Giovanni B., additional

Published
2020
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344. Clinical use of bioelectrical impedance analysis in patients affected by myotonic dystrophy type 1: A cross-sectional study

Author

Rinninella, Emanuele, primary, Silvestri, Gabriella, additional, Cintoni, Marco, additional, Perna, Alessia, additional, Martorana, Giuseppe Ettore, additional, De Lorenzo, Antonino, additional, Rossini, Paolo Maria, additional, Miggiano, Giacinto Abele Donato, additional, Gasbarrini, Antonio, additional, and Mele, Maria Cristina, additional

Published
2019
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345. Bilateral Theta Transcranial Alternating Current Stimulation (tACS) Modulates EEG Activity: When tACS Works Awake It Also Works Asleep

Author

D'Atri, Aurora, primary, Scarpelli, Serena, additional, Gorgoni, Maurizio, additional, Alfonsi, Valentina, additional, Annarumma, Ludovica, additional, Giannini, Anna Maria, additional, Ferrara, Michele, additional, Ferlazzo, Fabio, additional, Rossini, Paolo Maria, additional, and De Gennaro, Luigi, additional

Published
2019
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347. Upper limb joint kinematics using wearable magnetic and inertial measurement units: an anatomical calibration procedure based on bony landmark identification

Author

Picerno, Pietro, primary, Caliandro, Pietro, additional, Iacovelli, Chiara, additional, Simbolotti, Chiara, additional, Crabolu, Michele, additional, Pani, Danilo, additional, Vannozzi, Giuseppe, additional, Reale, Giuseppe, additional, Rossini, Paolo Maria, additional, Padua, Luca, additional, and Cereatti, Andrea, additional

Published
2019
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