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2,397 results on '"Schadt, Eric"'

301. Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice

Author

Zhao, Enpeng, Keller, Mark P., Rabaglia, Mary E., Oler, Angie T., Stapleton, Donnie S., Schueler, Kathryn L., Neto, Elias Chaibub, Moon, Jee Young, Wang, Ping, Wang, I-Ming, Lum, Pek Yee, Ivanovska, Irena, Cleary, Michele, Greenawalt, Danielle, Tsang, John, Choi, Youn Jeong, Kleinhanz, Robert, Shang, Jin, Zhou, Yun-Ping, Howard, Andrew D., Zhang, Bei B., Kendziorski, Christina, Thornberry, Nancy A., Yandell, Brian S., Schadt, Eric E., and Attie, Alan D.

Published
2009
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303. Biopsy and blood-based molecular biomarker of inflammation in IBD

Author

Argmann, Carmen, Hou, Ruixue, Ungaro, Ryan C, Irizar, Haritz, Al-Taie, Zainab, Huang, Ruiqi, Kosoy, Roman, Venkat, Swati, Song, Won-Min, Di'Narzo, Antonio F, Losic, Bojan, Hao, Ke, Peters, Lauren, Comella, Phillip H, Wei, Gabrielle, Atreja, Ashish, Mahajan, Milind, Iuga, Alina, Desai, Prerak T, Branigan, Patrick, Stojmirovic, Aleksandar, Perrigoue, Jacqueline, Brodmerkel, Carrie, Curran, Mark, Friedman, Joshua R, Hart, Amy, Lamousé-Smith, Esi, Wehkamp, Jan, Mehandru, Saurabh, Schadt, Eric E, Sands, Bruce E, Dubinsky, Marla C, Colombel, Jean-Frederic, Kasarskis, Andrew, and Suárez-Fariñas, Mayte

Abstract

ObjectiveIBD therapies and treatments are evolving to deeper levels of remission. Molecular measures of disease may augment current endpoints including the potential for less invasive assessments.DesignTranscriptome analysis on 712 endoscopically defined inflamed (Inf) and 1778 non-inflamed (Non-Inf) intestinal biopsies (n=498 Crohn’s disease, n=421 UC and 243 controls) in the Mount Sinai Crohn’s and Colitis Registry were used to identify genes differentially expressed between Inf and Non-Inf biopsies and to generate a molecular inflammation score (bMIS) via gene set variance analysis. A circulating MIS (cirMIS) score, reflecting intestinal molecular inflammation, was generated using blood transcriptome data. bMIS/cirMIS was validated as indicators of intestinal inflammation in four independent IBD cohorts.ResultsbMIS/cirMIS was strongly associated with clinical, endoscopic and histological disease activity indices. Patients with the same histologic score of inflammation had variable bMIS scores, indicating that bMIS describes a deeper range of inflammation. In available clinical trial data sets, both scores were responsive to IBD treatment. Despite similar baseline endoscopic and histologic activity, UC patients with lower baseline bMIS levels were more likely treatment responders compared with those with higher levels. Finally, among patients with UC in endoscopic and histologic remission, those with lower bMIS levels were less likely to have a disease flare over time.ConclusionTranscriptionally based scores provide an alternative objective and deeper quantification of intestinal inflammation, which could augment current clinical assessments used for disease monitoring and have potential for predicting therapeutic response and patients at higher risk of disease flares.

Published
2023
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306. Molecular networks as sensors and drivers of common human diseases

Author

Schadt, Eric E.

Subjects
Genomics -- Research -- Genetic aspects, Diseases -- United States -- Genetic aspects -- Research, Molecular biology -- Research -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation, Research, Genetic aspects
Abstract

The molecular biology revolution led to an intense focus on the study of interactions between DNA, RNA and protein biosynthesis in order to develop a more comprehensive understanding of the cell. One consequence of this focus was a reduced attention to whole-system physiology, making it difficult to link molecular biology to clinical medicine. Equipped with the tools emerging from the genomics revolution, we are now in a position to link molecular states to physiological ones through the reverse engineering of molecular networks that sense DNA and environmental perturbations and, as a result, drive variations in physiological states associated with disease., Our understanding of common human diseases and how best to treat them is hampered by the complexity of the human system in which they are manifested. Unlike simple Mendelian disorders, [...]

Published
2009

307. Genetic variants associated with inherited cardiovascular disorders among 13,131 asymptomatic older adults of European descent

Author

Lacaze, Paul, primary, Sebra, Robert, additional, Riaz, Moeen, additional, Ingles, Jodie, additional, Tiller, Jane, additional, Thompson, Bryony A., additional, James, Paul A., additional, Fatkin, Diane, additional, Semsarian, Christopher, additional, Reid, Christopher M., additional, Tonkin, Andrew M., additional, Winship, Ingrid, additional, Schadt, Eric, additional, and McNeil, John J., additional

Published
2021
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308. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population

Author

Riaz, Moeen, primary, Huq, Aamira, additional, Ryan, Joanne, additional, Orchard, Suzanne G, additional, Tiller, Jane, additional, Lockery, Jessica, additional, Woods, Robyn L., additional, Wolfe, Rory, additional, Renton, Alan E., additional, Goate, Alison M., additional, Sebra, Robert, additional, Schadt, Eric, additional, Brodtmann, Amy, additional, Shah, Raj C., additional, Storey, Elsdon, additional, Murray, Anne M, additional, McNeil, John J., additional, and Lacaze, Paul, additional

Published
2021
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310. Extracting longitudinal anticancer treatments at scale using deep natural language processing and temporal reasoning.

Author

Ma, Meng, primary, Lee, Kyeryoung, additional, Mai, Yun, additional, Gilman, Christopher, additional, Liu, Zongzhi, additional, Zhang, Mingwei, additional, Li, Minghao, additional, Redfern, Arielle, additional, Mullaney, Tommy, additional, Prentice, Tony, additional, McDonagh, Paul, additional, Pan, Qi, additional, Chen, Rong, additional, Schadt, Eric, additional, and Wang, Xiaoyan, additional

Published
2021
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311. Comparative efficacy of docetaxel versus novel hormonal agent in de novo metastatic hormone-sensitive prostate cancer: Real-world data curated by deidentified chart abstraction.

Author

Liaw, Bobby Chi-Hung, primary, Guin, Sunny, additional, Jun, Tomi, additional, Ayers, Kristin, additional, Patel, Bonny, additional, O'Connell, Timmy, additional, Dietz, Matthew, additional, Klein, Michael, additional, Prentice, Tony, additional, Newman, Scott, additional, Fink, Marc, additional, Zhou, Xiang, additional, Schadt, Eric, additional, Chen, Rong, additional, and Oh, William K., additional

Published
2021
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313. Analyzing treatment patterns and time to the next treatment in chronic lymphocytic leukemia real-world data using automated temporal phenotyping.

Author

Lee, Kyeryoung, primary, Liu, Zongzhi, additional, Ma, Meng, additional, Mai, Yun, additional, Gilman, Christopher, additional, Li, Minghao, additional, Zhang, Mingwei, additional, Mullaney, Tommy, additional, Pan, Qi, additional, Chen, Rong, additional, Schadt, Eric, additional, and Wang, Xiaoyan, additional

Published
2021
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314. Phenotyping of clinical trial eligibility text from cancer studies into computable criteria in electronic health records.

Author

Mai, Yun, primary, Lee, Kyeryoung, additional, Liu, Zongzhi, additional, Ma, Meng, additional, Gilman, Christopher, additional, Li, Minghao, additional, Zhang, Mingwei, additional, Li, Zhiqiang, additional, Fink, Marc, additional, Mullaney, Tommy, additional, Prentice, Tony, additional, Ghosh, Krish, additional, Makosiej, Frank, additional, Pan, Qi, additional, Chen, Rong, additional, Schadt, Eric, additional, and Wang, Xiaoyan, additional

Published
2021
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315. Analysis of Real-World Data to Investigate the Impact of Race and Ethnicity on Response to Programmed Cell Death-1 and Programmed Cell Death-Ligand 1 Inhibitors in Advanced Non-Small Cell Lung Cancers

Author

Ayers, Kristin L., primary, Mullaney, Tommy, additional, Zhou, Xiang, additional, Liu, Jane J., additional, Lee, Kyeryoung, additional, Ma, Meng, additional, Jones, Scott, additional, Li, Li, additional, Redfern, Arielle, additional, Jappe, Whitney, additional, Liu, Zongzhi, additional, Goldsweig, Howard, additional, Yadav, Kamlesh K., additional, Hahner, Nicholas, additional, Dietz, Matthew, additional, Zimmerman, Michelle, additional, Prentice, Tony, additional, Newman, Scott, additional, Veluswamy, Rajwanth, additional, Wisnivesky, Juan, additional, Hirsch, Fred R., additional, Oh, William K., additional, Li, Shuyu D., additional, Schadt, Eric E., additional, and Chen, Rong, additional

Published
2021
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317. A composite biomarker of neutrophil-lymphocyte ratio and hemoglobin level correlates with clinical response to PD-1 and PD-L1 inhibitors in advanced non-small cell lung cancers

Author

Ayers, Kristin L., primary, Ma, Meng, additional, Debussche, Gaspard, additional, Corrigan, David, additional, McCafferty, Jonathan, additional, Lee, Kyeryoung, additional, Newman, Scott, additional, Zhou, Xiang, additional, Hirsch, Fred R., additional, Mack, Philip C., additional, Liu, Jane J., additional, Schadt, Eric E., additional, Chen, Rong, additional, and Li, Shuyu D., additional

Published
2021
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318. Haploinsufficiency of POU4F1 causes an ataxia syndrome with hypotonia and intention tremor

Author

Webb, Bryn D., primary, Evans, Anthony, additional, Naidich, Thomas P., additional, Bird, Lynne M., additional, Parikh, Sumit, additional, Fernandez Garcia, Meilin, additional, Henderson, Lindsay B., additional, Millan, Francisca, additional, Si, Yue, additional, Brennand, Kristen J., additional, Hung, Peter, additional, Rucker, Janet C., additional, Wheeler, Patricia G., additional, and Schadt, Eric E., additional

Published
2021
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319. Integrative Network Analysis of Early-Stage Lung Adenocarcinoma Identifies Aurora Kinase Inhibition as Interceptor of Invasion and Progression

Author

Yoo, Seungyeul, primary, Sinha, Abhilasha, additional, Yang, Dawei, additional, Altorki, Nasser, additional, Tandon, Radhika, additional, Wang, Wenhui, additional, Chavez, Deebly, additional, Lee, Eunjee, additional, Patel, Ayushi, additional, Sato, Takashi, additional, Kong, Ranran, additional, Ding, Bisen, additional, Schadt, Eric, additional, Watanabe, Hideo, additional, Massion, Pierre, additional, Borczuk, Alain, additional, Zhu, Jun, additional, and Powell, Charles, additional

Published
2021
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320. COVID-19 outcomes among hospitalized men with or without exposure to alpha-1-adrenergic receptor blocking agents

Author

Li, Shilong, primary, Jun, Tomi, additional, Wang, Zichen, additional, Kao, Yu-Han, additional, Schadt, Emilio, additional, Konig, Maximilian F., additional, Bettegowda, Chetan, additional, Vogelstein, Joshua T., additional, Papadopoulos, Nickolas, additional, Parsons, Ramon E., additional, Chen, Rong, additional, Schadt, Eric E., additional, Li, Li, additional, and Oh, William K., additional

Published
2021
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321. Myeloid Cell–associated Resistance to PD-1/PD-L1 Blockade in Urothelial Cancer Revealed Through Bulk and Single-cell RNA Sequencing

Author

Wang, Li, primary, Sfakianos, John P., additional, Beaumont, Kristin G., additional, Akturk, Guray, additional, Horowitz, Amir, additional, Sebra, Robert P., additional, Farkas, Adam M., additional, Gnjatic, Sacha, additional, Hake, Austin, additional, Izadmehr, Sudeh, additional, Wiklund, Peter, additional, Oh, William K., additional, Szabo, Peter M., additional, Wind-Rotolo, Megan, additional, Unsal-Kacmaz, Keziban, additional, Yao, Xin, additional, Schadt, Eric, additional, Sharma, Padmanee, additional, Bhardwaj, Nina, additional, Zhu, Jun, additional, and Galsky, Matthew D., additional

Published
2021
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322. Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry

Author

Graff, Mariaelisa, primary, Justice, Anne E., additional, Young, Kristin L., additional, Marouli, Eirini, additional, Zhang, Xinruo, additional, Fine, Rebecca S., additional, Lim, Elise, additional, Buchanan, Victoria, additional, Rand, Kristin, additional, Feitosa, Mary F., additional, Wojczynski, Mary K., additional, Yanek, Lisa R., additional, Shao, Yaming, additional, Rohde, Rebecca, additional, Adeyemo, Adebowale A., additional, Aldrich, Melinda C., additional, Allison, Matthew A., additional, Ambrosone, Christine B., additional, Ambs, Stefan, additional, Amos, Christopher, additional, Arnett, Donna K., additional, Atwood, Larry, additional, Bandera, Elisa V., additional, Bartz, Traci, additional, Becker, Diane M., additional, Berndt, Sonja I., additional, Bernstein, Leslie, additional, Bielak, Lawrence F., additional, Blot, William J., additional, Bottinger, Erwin P., additional, Bowden, Donald W., additional, Bradfield, Jonathan P., additional, Brody, Jennifer A., additional, Broeckel, Ulrich, additional, Burke, Gregory, additional, Cade, Brian E., additional, Cai, Qiuyin, additional, Caporaso, Neil, additional, Carlson, Chris, additional, Carpten, John, additional, Casey, Graham, additional, Chanock, Stephen J., additional, Chen, Guanjie, additional, Chen, Minhui, additional, Chen, Yii-Der I., additional, Chen, Wei-Min, additional, Chesi, Alessandra, additional, Chiang, Charleston W.K., additional, Chu, Lisa, additional, Coetzee, Gerry A., additional, Conti, David V., additional, Cooper, Richard S., additional, Cushman, Mary, additional, Demerath, Ellen, additional, Deming, Sandra L., additional, Dimitrov, Latchezar, additional, Ding, Jingzhong, additional, Diver, W. Ryan, additional, Duan, Qing, additional, Evans, Michele K., additional, Falusi, Adeyinka G., additional, Faul, Jessica D., additional, Fornage, Myriam, additional, Fox, Caroline, additional, Freedman, Barry I., additional, Garcia, Melissa, additional, Gillanders, Elizabeth M., additional, Goodman, Phyllis, additional, Gottesman, Omri, additional, Grant, Struan F.A., additional, Guo, Xiuqing, additional, Hakonarson, Hakon, additional, Haritunians, Talin, additional, Harris, Tamara B., additional, Harris, Curtis C., additional, Henderson, Brian E., additional, Hennis, Anselm, additional, Hernandez, Dena G., additional, Hirschhorn, Joel N., additional, McNeill, Lorna Haughton, additional, Howard, Timothy D., additional, Howard, Barbara, additional, Hsing, Ann W., additional, Hsu, Yu-Han H., additional, Hu, Jennifer J., additional, Huff, Chad D., additional, Huo, Dezheng, additional, Ingles, Sue A., additional, Irvin, Marguerite R., additional, John, Esther M., additional, Johnson, Karen C., additional, Jordan, Joanne M., additional, Kabagambe, Edmond K., additional, Kang, Sun J., additional, Kardia, Sharon L., additional, Keating, Brendan J., additional, Kittles, Rick A., additional, Klein, Eric A., additional, Kolb, Suzanne, additional, Kolonel, Laurence N., additional, Kooperberg, Charles, additional, Kuller, Lewis, additional, Kutlar, Abdullah, additional, Lange, Leslie, additional, Langefeld, Carl D., additional, Le Marchand, Loic, additional, Leonard, Hampton, additional, Lettre, Guillaume, additional, Levin, Albert M., additional, Li, Yun, additional, Li, Jin, additional, Liu, Yongmei, additional, Liu, Youfang, additional, Liu, Simin, additional, Lohman, Kurt, additional, Lotay, Vaneet, additional, Lu, Yingchang, additional, Maixner, William, additional, Manson, JoAnn E., additional, McKnight, Barbara, additional, Meng, Yan, additional, Monda, Keri L., additional, Monroe, Kris, additional, Moore, Jason H., additional, Mosley, Thomas H., additional, Mudgal, Poorva, additional, Murphy, Adam B., additional, Nadukuru, Rajiv, additional, Nalls, Mike A., additional, Nathanson, Katherine L., additional, Nayak, Uma, additional, N’Diaye, Amidou, additional, Nemesure, Barbara, additional, Neslund-Dudas, Christine, additional, Neuhouser, Marian L., additional, Nyante, Sarah, additional, Ochs-Balcom, Heather, additional, Ogundiran, Temidayo O., additional, Ogunniyi, Adesola, additional, Ojengbede, Oladosu, additional, Okut, Hayrettin, additional, Olopade, Olufunmilayo I., additional, Olshan, Andrew, additional, Padhukasahasram, Badri, additional, Palmer, Julie, additional, Palmer, Cameron D., additional, Palmer, Nicholette D., additional, Papanicolaou, George, additional, Patel, Sanjay R., additional, Pettaway, Curtis A., additional, Peyser, Patricia A., additional, Press, Michael F., additional, Rao, D.C., additional, Rasmussen-Torvik, Laura J., additional, Redline, Susan, additional, Reiner, Alex P., additional, Rhie, Suhn K., additional, Rodriguez-Gil, Jorge L., additional, Rotimi, Charles N., additional, Rotter, Jerome I., additional, Ruiz-Narvaez, Edward A., additional, Rybicki, Benjamin A., additional, Salako, Babatunde, additional, Sale, Michele M., additional, Sanderson, Maureen, additional, Schadt, Eric, additional, Schreiner, Pamela J., additional, Schurmann, Claudia, additional, Schwartz, Ann G., additional, Shriner, Daniel A., additional, Signorello, Lisa B., additional, Singleton, Andrew B., additional, Siscovick, David S., additional, Smith, Jennifer A., additional, Smith, Shad, additional, Speliotes, Elizabeth, additional, Spitz, Margaret, additional, Stanford, Janet L., additional, Stevens, Victoria L., additional, Stram, Alex, additional, Strom, Sara S., additional, Sucheston, Lara, additional, Sun, Yan V., additional, Tajuddin, Salman M., additional, Taylor, Herman, additional, Taylor, Kira, additional, Tayo, Bamidele O., additional, Thun, Michael J., additional, Tucker, Margaret A., additional, Vaidya, Dhananjay, additional, Van Den Berg, David J., additional, Vedantam, Sailaja, additional, Vitolins, Mara, additional, Wang, Zhaoming, additional, Ware, Erin B., additional, Wassertheil-Smoller, Sylvia, additional, Weir, David R., additional, Wiencke, John K., additional, Williams, Scott M., additional, Williams, L. Keoki, additional, Wilson, James G., additional, Witte, John S., additional, Wrensch, Margaret, additional, Wu, Xifeng, additional, Yao, Jie, additional, Zakai, Neil, additional, Zanetti, Krista, additional, Zemel, Babette S., additional, Zhao, Wei, additional, Zhao, Jing Hua, additional, Zheng, Wei, additional, Zhi, Degui, additional, Zhou, Jie, additional, Zhu, Xiaofeng, additional, Ziegler, Regina G., additional, Zmuda, Joe, additional, Zonderman, Alan B., additional, Psaty, Bruce M., additional, Borecki, Ingrid B., additional, Cupples, L. Adrienne, additional, Liu, Ching-Ti, additional, Haiman, Christopher A., additional, Loos, Ruth, additional, Ng, Maggie C.Y., additional, and North, Kari E., additional

Published
2021
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323. Proteogenomic and metabolomic characterization of human glioblastoma

Author

Wang, Liang-Bo, primary, Karpova, Alla, additional, Gritsenko, Marina A., additional, Kyle, Jennifer E., additional, Cao, Song, additional, Li, Yize, additional, Rykunov, Dmitry, additional, Colaprico, Antonio, additional, Rothstein, Joseph H., additional, Hong, Runyu, additional, Stathias, Vasileios, additional, Cornwell, MacIntosh, additional, Petralia, Francesca, additional, Wu, Yige, additional, Reva, Boris, additional, Krug, Karsten, additional, Pugliese, Pietro, additional, Kawaler, Emily, additional, Olsen, Lindsey K., additional, Liang, Wen-Wei, additional, Song, Xiaoyu, additional, Dou, Yongchao, additional, Wendl, Michael C., additional, Caravan, Wagma, additional, Liu, Wenke, additional, Cui Zhou, Daniel, additional, Ji, Jiayi, additional, Tsai, Chia-Feng, additional, Petyuk, Vladislav A., additional, Moon, Jamie, additional, Ma, Weiping, additional, Chu, Rosalie K., additional, Weitz, Karl K., additional, Moore, Ronald J., additional, Monroe, Matthew E., additional, Zhao, Rui, additional, Yang, Xiaolu, additional, Yoo, Seungyeul, additional, Krek, Azra, additional, Demopoulos, Alexis, additional, Zhu, Houxiang, additional, Wyczalkowski, Matthew A., additional, McMichael, Joshua F., additional, Henderson, Brittany L., additional, Lindgren, Caleb M., additional, Boekweg, Hannah, additional, Lu, Shuangjia, additional, Baral, Jessika, additional, Yao, Lijun, additional, Stratton, Kelly G., additional, Bramer, Lisa M., additional, Zink, Erika, additional, Couvillion, Sneha P., additional, Bloodsworth, Kent J., additional, Satpathy, Shankha, additional, Sieh, Weiva, additional, Boca, Simina M., additional, Schürer, Stephan, additional, Chen, Feng, additional, Wiznerowicz, Maciej, additional, Ketchum, Karen A., additional, Boja, Emily S., additional, Kinsinger, Christopher R., additional, Robles, Ana I., additional, Hiltke, Tara, additional, Thiagarajan, Mathangi, additional, Nesvizhskii, Alexey I., additional, Zhang, Bing, additional, Mani, D.R., additional, Ceccarelli, Michele, additional, Chen, Xi S., additional, Cottingham, Sandra L., additional, Li, Qing Kay, additional, Kim, Albert H., additional, Fenyö, David, additional, Ruggles, Kelly V., additional, Rodriguez, Henry, additional, Mesri, Mehdi, additional, Payne, Samuel H., additional, Resnick, Adam C., additional, Wang, Pei, additional, Smith, Richard D., additional, Iavarone, Antonio, additional, Chheda, Milan G., additional, Barnholtz-Sloan, Jill S., additional, Rodland, Karin D., additional, Liu, Tao, additional, Ding, Li, additional, Agarwal, Anupriya, additional, Amin, Mitual, additional, An, Eunkyung, additional, Anderson, Matthew L., additional, Andrews, David W., additional, Bauer, Thomas, additional, Birger, Chet, additional, Birrer, Michael J., additional, Blumenberg, Lili, additional, Bocik, William E., additional, Borate, Uma, additional, Borucki, Melissa, additional, Burke, Meghan C., additional, Cai, Shuang, additional, Calinawan, Anna P., additional, Carr, Steven A., additional, Cerda, Sandra, additional, Chan, Daniel W., additional, Charamut, Alyssa, additional, Chen, Lin S., additional, Chesla, David, additional, Chinnaiyan, Arul M., additional, Chowdhury, Shrabanti, additional, Cieślik, Marcin P., additional, Clark, David J., additional, Culpepper, Houston, additional, Czernicki, Tomasz, additional, D'Angelo, Fulvio, additional, Day, Jacob, additional, De Young, Stephanie, additional, Demir, Emek, additional, Dhanasekaran, Saravana Mohan, additional, Dhir, Rajiv, additional, Domagalski, Marcin J., additional, Druker, Brian, additional, Duffy, Elizabeth, additional, Dyer, Maureen, additional, Edwards, Nathan J., additional, Edwards, Robert, additional, Elburn, Kimberly, additional, Ellis, Matthew J., additional, Eschbacher, Jennifer, additional, Francis, Alicia, additional, Gabriel, Stacey, additional, Gabrovski, Nikolay, additional, Garofano, Luciano, additional, Getz, Gad, additional, Gillette, Michael A., additional, Godwin, Andrew K., additional, Golbin, Denis, additional, Hanhan, Ziad, additional, Hannick, Linda I., additional, Hariharan, Pushpa, additional, Hindenach, Barbara, additional, Hoadley, Katherine A., additional, Hostetter, Galen, additional, Huang, Chen, additional, Jaehnig, Eric, additional, Jewell, Scott D., additional, Ji, Nan, additional, Jones, Corbin D., additional, Karz, Alcida, additional, Kaspera, Wojciech, additional, Kim, Lyndon, additional, Kothadia, Ramani B., additional, Kumar-Sinha, Chandan, additional, Lei, Jonathan, additional, Leprevost, Felipe D., additional, Li, Kai, additional, Liao, Yuxing, additional, Lilly, Jena, additional, Liu, Hongwei, additional, Lubínski, Jan, additional, Madan, Rashna, additional, Maggio, William, additional, Malc, Ewa, additional, Malovannaya, Anna, additional, Mareedu, Sailaja, additional, Markey, Sanford P., additional, Marrero-Oliveras, Annette, additional, Martinez, Nina, additional, Maunganidze, Nicollette, additional, McDermott, Jason E., additional, McGarvey, Peter B., additional, McGee, John, additional, Mieczkowski, Piotr, additional, Migliozzi, Simona, additional, Modugno, Francesmary, additional, Montgomery, Rebecca, additional, Newton, Chelsea J., additional, Omenn, Gilbert S., additional, Ozbek, Umut, additional, Paklina, Oxana V., additional, Paulovich, Amanda G., additional, Perou, Amy M., additional, Pico, Alexander R., additional, Piehowski, Paul D., additional, Placantonakis, Dimitris G., additional, Polonskaya, Larisa, additional, Potapova, Olga, additional, Pruetz, Barbara, additional, Qi, Liqun, additional, Ramkissoon, Shakti, additional, Resnick, Adam, additional, Richey, Shannon, additional, Riggins, Gregory, additional, Robinson, Karna, additional, Roche, Nancy, additional, Rohrer, Daniel C., additional, Rood, Brian R., additional, Rossell, Larissa, additional, Savage, Sara R., additional, Schadt, Eric E., additional, Shi, Yan, additional, Shi, Zhiao, additional, Shutack, Yvonne, additional, Singh, Shilpi, additional, Skelly, Tara, additional, Sokoll, Lori J., additional, Stawicki, Jakub, additional, Stein, Stephen E., additional, Suh, James, additional, Szopa, Wojciech, additional, Tabor, Dave, additional, Tan, Donghui, additional, Tansil, Darlene, additional, Thangudu, Ratna R., additional, Tognon, Cristina, additional, Traer, Elie, additional, Tsang, Shirley, additional, Tyner, Jeffrey, additional, Um, Ki Sung, additional, Valley, Dana R., additional, Vasaikar, Suhas, additional, Vatanian, Negin, additional, Velvulou, Uma, additional, Vernon, Michael, additional, Wan, Weiqing, additional, Wang, Junmei, additional, Webster, Alex, additional, Wen, Bo, additional, Whiteaker, Jeffrey R., additional, Wilson, George D., additional, Zakhartsev, Yuriy, additional, Zelt, Robert, additional, Zhang, Hui, additional, Zhang, Liwei, additional, Zhang, Zhen, additional, Zhao, Grace, additional, and Zhu, Jun, additional

Published
2021
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325. Variations in DNA elucidate molecular networks that cause disease

Author

Chen, Yanqing, Zhu, Jun, Lum, Pek Yee, Yang, Xia, Pinto, Shirly, Macneil, Douglas J., Zhang, Chunsheng, Lamb, John, Edwards, Stephen, Sieberts, Solveig K., Leonardson, Amy, Castellini, Lawrence W., Wang, Susana, Champy, Marie-France, Zhang, Bin, Emilsson, Valur, Doss, Sudheer, Ghazalpour, Anatole, Horvath, Steve, Drake, Thomas A., Lusis, Aldonis J., and Schadt, Eric E.

Subjects
Molecular neurobiology -- Research -- Genetic aspects, Quantitative trait loci -- Research -- Genetic aspects, Genetic variation -- Research -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Research, Multifactorial traits -- Research -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation, Research, Genetic aspects
Abstract

Identifying variations in DNA that increase susceptibility to disease is one of the primary aims of genetic studies using a forward genetics approach. However, identification of disease-susceptibility genes by means [...]

Published
2008

326. Genetics of gene expression and its effect on disease

Author

Emilsson, Valur, Thorleifson, Gudmar, Zhang, Bin, Leonardson, Amy S., Zink, Florian, Zhu, Jun, Carlson, Sonia, Helgason, Agnar, Walters, G. Bragi, Gunnarsdottir, Steinunn, Mouy, Magali, Steinthorsdottir, Valgerdur, Eiriksdottir, Gudrun H., Bjornsdottir, Gyda, Reynisdottir, Inga, Gudbjartsson, Daniel, Helgadottir, Anna, Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Styrkarsdottir, Unnur, Gretarsdottir, Solveig, Magnusson, Kristinn P., Stefansson, Hreinn, Fossdal, Ragnheidur, Kristjansson, Kristleifur, Gislason, Hjortur G., Stefansson, Tryggvi, Leifsson, Bjorn G., Thorsteinsdottir, Unnur, Lamb, John R., Gulcher, Jeffrey R., Reitman, Marc L., Kong, Augustine, Schadt, Eric E., and Stefansson, Kari

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Common human diseases result from the interplay of many genes and environmental factors. Therefore, a more integrative biology approach is needed to unravel the complexity and causes of such diseases. [...]

Published
2008

329. Additional file 1 of A reference profile-free deconvolution method to infer cancer cell-intrinsic subtypes and tumor-type-specific stromal profiles

Author

Wang, Li, Sebra, Robert, Sfakianos, John, Kimaada Allette, Wenhui Wang, Seungyeul Yoo, Bhardwaj, Nina, Schadt, Eric, Yao, Xin, Galsky, Matthew, and Zhu, Jun

Abstract

Additional file 1 : Figure S1. A schematic illustration of DeClust algorithm. Figure S2 Flowchart of the study. Figure S3. Simulation results when gene expression was simulated under negative binomial distribution. Details can be found in legend of Fig. 1. Figure S4. Simulation results when gene expression was simulated under negative binomial distribution. Details can be found in legend of Fig. 1. Figure S5. Comparing cell fraction estimations by different gene expression deconvolution methods with the ones based on MethyCIBERSORT (treated as “ground truth”) for immune compartment (AB) and stromal compartment (CD) using Spearman’s correlation coefficients (AC) or Median Absolute Deviation (BD). The p-values above are the difference between DeClust and other methods according the two-sided paired t-test. Figure S6. Kaplan-Meier curves of patients with high/low stromal compartment fractions as defined by DeClust (left) and ESTIMATE (right) in TCGA dataset (top) and non-TCGA dataset (bottom) for KIRC (A) and BLCA (B). Figure S7. Pathway analysis of stromal proles across 13 TCGA datasets using Canonical pathways (left) or hallmark_cancer pathways (right) from MsigDB. The color indicates the significance of the up/down-regulation of that pathway in that stromal prole as compared to other stromal proles (−log10 (p-value of Wilcoxon rank-sum test), see Method). Red color represents up-regulation and blue color represents down-regulation. Figure S8. Number of genes with subtype-specific methylation before (A) and after (B) methylation correlated with immune or stromal cell frequencies were removed. Figure S9. Overlap between CRIS subtypes and subtypes defined by different methods. Figure S10. Plots of the correlation between tumor purity (Consensus Purity Estimation*) and subtypes defined by different methods, grouped by methods (A) or by cancer types (B). Figure S11. Kaplan-Meier curves of DeClust subtypes (left) and TCGA subtypes (right) for TCGA dataset (top) and non-TCGA dataset (bottom) for KIRP (A), KIRC (B) and LUAD (C). Figure S12. (A) Spearman’s correlation coefficient between immune and stromal proles estimated by DeClust (y-axis) and reference proles used by EPIC (x-axis). (B) Exemplary scatter plot of reference expression prole versus immune and stromal prole estimated by Declust using TCGA BLCA dataset.(C) Correlation between different reference proles(x-axis) and bulk tissue expression proles (gray), immune proles (red) and stromal proles (blue) estimated by DeClust using TCGA BLCA dataset. (D) Cell type-specific markers identified in EPIC reference proles and their expression in immune and stromal proles estimated by DeClust. Figure S13. t-SNE plot of scRNAseq data for pRCC samples. Cell-type specific markers used to annotate the cell clusters were shown below. Figure S14. Correlation between mean expression prole of each epithelial cell cluster and subtype-specific cancer proles estimated by DeClust or by TCGA for ccRCC scRNAseq data (A) and pRCC scRNAseq data(B). Error bars indicated 95% confidence intervals. Figure S15. Comparison of inferred cancer proles and scRNAseq data. Figure S16. Violin plot of estimated immune (left) and stromal (fraction) fraction in each subtype of BLCA. Figure S17. Proportions of different immune subtypes within each subtypes defined by DeClust. Figure S18. Comparison of immune subtypes and subtypes defined by DeClust in association with overall survival. Plots are grouped by methods (A) and by cancer types(B). Figure S19. (A) The association of overall survival and immune subtypes within each cancer cell-intrinsic subtype defined by Declust.(B) Kaplan-Meier curves of immune subtypes within Atypical_1 subtype of HNSC. Figure S20. (A) The association of overall survival and immune/stromal cell fraction within each subtype defined by Declust. The color in the heatmap represents the –log10(p-value) of the association (log rank test). Red means the higher cell fraction corresponds to worse survival, and blue means the opposite. Only cancer subtypes and cell fractions with at least one significant association (p

Published
2020
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330. Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach

Author

Mendelson, Michael M., Marioni, Riccardo E., Joehanes, Roby, Liu, Chunyu, Hedman, Åsa K., Aslibekyan, Stella, Demerath, Ellen W., Guan, Weihua, Zhi, Degui, Yao, Chen, Huan, Tianxiao, Willinger, Christine, Chen, Brian, Courchesne, Paul, Multhaup, Michael, Irvin, Marguerite R., Cohain, Ariella, Schadt, Eric E., Grove, Megan L., Bressler, Jan, North, Kari, Sundström, Johan, Gustafsson, Stefan, Shah, Sonia, McRae, Allan F., Harris, Sarah E., Gibson, Jude, Redmond, Paul, Corley, Janie, Murphy, Lee, Starr, John M., Kleinbrink, Erica, Lipovich, Leonard, Visscher, Peter M., Wray, Naomi R., Krauss, Ronald M., Fallin, Daniele, Feinberg, Andrew, Absher, Devin M., Fornage, Myriam, Pankow, James S., Lind, Lars, Fox, Caroline, Ingelsson, Erik, Arnett, Donna K., Boerwinkle, Eric, Liang, Liming, Levy, Daniel, and Deary, Ian J.

Subjects
Metabolic diseases -- Diagnosis -- Genetic aspects, Methylation -- Health aspects, Body mass index -- Health aspects, Cardiovascular diseases -- Diagnosis -- Genetic aspects, Biological sciences
Abstract

Background The link between DNA methylation, obesity, and adiposity-related diseases in the general population remains uncertain. Methods and Findings We conducted an association study of body mass index (BMI) and differential methylation for over 400,000 CpGs assayed by microarray in whole-blood-derived DNA from 3,743 participants in the Framingham Heart Study and the Lothian Birth Cohorts, with independent replication in three external cohorts of 4,055 participants. We examined variations in whole blood gene expression and conducted Mendelian randomization analyses to investigate the functional and clinical relevance of the findings. We identified novel and previously reported BMI-related differential methylation at 83 CpGs that replicated across cohorts; BMI-related differential methylation was associated with concurrent changes in the expression of genes in lipid metabolism pathways. Genetic instrumental variable analysis of alterations in methylation at one of the 83 replicated CpGs, cg11024682 (intronic to sterol regulatory element binding transcription factor 1 [SREBF1]), demonstrated links to BMI, adiposity-related traits, and coronary artery disease. Independent genetic instruments for expression of SREBF1 supported the findings linking methylation to adiposity and cardiometabolic disease. Methylation at a substantial proportion (16 of 83) of the identified loci was found to be secondary to differences in BMI. However, the cross-sectional nature of the data limits definitive causal determination. Conclusions We present robust associations of BMI with differential DNA methylation at numerous loci in blood cells. BMI-related DNA methylation and gene expression provide mechanistic insights into the relationship between DNA methylation, obesity, and adiposity-related diseases., Author(s): Michael M. Mendelson 1,2,3,4, Riccardo E. Marioni 5,6,7, Roby Joehanes 1,4,8, Chunyu Liu 1,4,9,Åsa K. Hedman 10, Stella Aslibekyan 11, Ellen W. Demerath 12, Weihua Guan 13, Degui Zhi [...]

Published
2017
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333. Pharmacogenetics of metformin response: a step in the path toward personalized medicine

Author

Reitman, Marc L. and Schadt, Eric E.

Subjects
Diabetes -- Research, Diabetes -- Care and treatment, Diabetes -- Analysis, Pharmacogenetics -- Research, Pharmacogenetics -- Analysis
Abstract

Type 2 diabetes mellitus affects 9.6% of the adults in the United States and more than 200 million people worldwide. Diabetes can be a devastating disease, but it can now [...]

Published
2007

334. Integrative Approach to Sporadic Alzheimer’s Disease: Deficiency of driver Tyrobp/Dap12 in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden

Author

Haure-Mirande, Jean-Vianney, Wang, Minghui, Audrain, Mickael, Fanutza, Tomas, Kim, Soong Ho, Heja, Szilvia, Readhead, Ben, Dudley, Joel T., Blitzer, Robert D., Schadt, Eric E., Zhang, Bin, Gandy, Sam, and Ehrlich, Michelle E.

Subjects
Article
Abstract

Integrative gene network approaches enable new avenues of exploration that implicate causal genes in sporadic late onset Alzheimer’s disease (LOAD) pathogenesis, thereby offering novel insights for drug discovery programs. We previously constructed a probabilistic causal network model of sporadic LOAD and identified TYROBP/DAP12, a microglial transmembrane signaling polypeptide and direct adapter of TREM2, as the most robust key driver gene in the network. Here we show that absence of TYROBP/DAP12 in a mouse model of AD-type cerebral Aβ amyloidosis (APPKM670/671NL/PSEN1Δexon9) recapitulates the expected network characteristics by normalizing the transcriptome of APP/PSEN1 mice and repressing the induction of genes involved in the switch from homeostatic microglia to disease-associated microglia (DAM), including Trem2, complement (C1qa, C1qb, C1qc, Itgax), Clec7a and Cst7. Importantly, we show that constitutive absence of TYROBP/DAP12 in the amyloidosis mouse model prevented appearance of the electrophysiological and learning behavior alterations associated with the phenotype of APPKM670/671NL/PSEN1Δexon9 mice. Our results suggest that TYROBP/DAP12 could represent a novel therapeutic target to slow, arrest, or prevent the development of sporadic LOAD. These data establish that the network pathology observed in postmortem human LOAD brain can be faithfully recapitulated in the brain of a genetically manipulated mouse. These data also validate our multiscale gene networks by demonstrating how the networks intersect with the standard neuropathological features of LOAD.

Published
2018

335. Genomic analyses implicate noncoding de novo variants in congenital heart disease.

Author

Richter, Felix, Richter, Felix, Morton, Sarah U, Kim, Seong Won, Kitaygorodsky, Alexander, Wasson, Lauren K, Chen, Kathleen M, Zhou, Jian, Qi, Hongjian, Patel, Nihir, DePalma, Steven R, Parfenov, Michael, Homsy, Jason, Gorham, Joshua M, Manheimer, Kathryn B, Velinder, Matthew, Farrell, Andrew, Marth, Gabor, Schadt, Eric E, Kaltman, Jonathan R, Newburger, Jane W, Giardini, Alessandro, Goldmuntz, Elizabeth, Brueckner, Martina, Kim, Richard, Porter, George A, Bernstein, Daniel, Chung, Wendy K, Srivastava, Deepak, Tristani-Firouzi, Martin, Troyanskaya, Olga G, Dickel, Diane E, Shen, Yufeng, Seidman, Jonathan G, Seidman, Christine E, Gelb, Bruce D, Richter, Felix, Richter, Felix, Morton, Sarah U, Kim, Seong Won, Kitaygorodsky, Alexander, Wasson, Lauren K, Chen, Kathleen M, Zhou, Jian, Qi, Hongjian, Patel, Nihir, DePalma, Steven R, Parfenov, Michael, Homsy, Jason, Gorham, Joshua M, Manheimer, Kathryn B, Velinder, Matthew, Farrell, Andrew, Marth, Gabor, Schadt, Eric E, Kaltman, Jonathan R, Newburger, Jane W, Giardini, Alessandro, Goldmuntz, Elizabeth, Brueckner, Martina, Kim, Richard, Porter, George A, Bernstein, Daniel, Chung, Wendy K, Srivastava, Deepak, Tristani-Firouzi, Martin, Troyanskaya, Olga G, Dickel, Diane E, Shen, Yufeng, Seidman, Jonathan G, Seidman, Christine E, and Gelb, Bruce D

Abstract

A genetic etiology is identified for one-third of patients with congenital heart disease (CHD), with 8% of cases attributable to coding de novo variants (DNVs). To assess the contribution of noncoding DNVs to CHD, we compared genome sequences from 749 CHD probands and their parents with those from 1,611 unaffected trios. Neural network prediction of noncoding DNV transcriptional impact identified a burden of DNVs in individuals with CHD (n = 2,238 DNVs) compared to controls (n = 4,177; P = 8.7 × 10-4). Independent analyses of enhancers showed an excess of DNVs in associated genes (27 genes versus 3.7 expected, P = 1 × 10-5). We observed significant overlap between these transcription-based approaches (odds ratio (OR) = 2.5, 95% confidence interval (CI) 1.1-5.0, P = 5.4 × 10-3). CHD DNVs altered transcription levels in 5 of 31 enhancers assayed. Finally, we observed a DNV burden in RNA-binding-protein regulatory sites (OR = 1.13, 95% CI 1.1-1.2, P = 8.8 × 10-5). Our findings demonstrate an enrichment of potentially disruptive regulatory noncoding DNVs in a fraction of CHD at least as high as that observed for damaging coding DNVs.

Published
2020

336. Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies

Author

MDL onderzoek 1, Onderzoek Precision medicine, Child Health, Zorg en O&O, Infection & Immunity, Regenerative Medicine and Stem Cells, CMM Sectie Molecular Cancer Research, Cancer, Hubrecht Institute with UMC, Ouahed, Jodie, Spencer, Elizabeth, Kotlarz, Daniel, Shouval, Dror S, Kowalik, Matthew, Peng, Kaiyue, Field, Michael, Grushkin-Lerner, Leslie, Pai, Sung-Yun, Bousvaros, Athos, Cho, Judy, Argmann, Carmen, Schadt, Eric, Mcgovern, Dermot P B, Mokry, Michal, Nieuwenhuis, Edward, Clevers, Hans, Powrie, Fiona, Uhlig, Holm, Klein, Christoph, Muise, Aleixo, Dubinsky, Marla, Snapper, Scott B, MDL onderzoek 1, Onderzoek Precision medicine, Child Health, Zorg en O&O, Infection & Immunity, Regenerative Medicine and Stem Cells, CMM Sectie Molecular Cancer Research, Cancer, Hubrecht Institute with UMC, Ouahed, Jodie, Spencer, Elizabeth, Kotlarz, Daniel, Shouval, Dror S, Kowalik, Matthew, Peng, Kaiyue, Field, Michael, Grushkin-Lerner, Leslie, Pai, Sung-Yun, Bousvaros, Athos, Cho, Judy, Argmann, Carmen, Schadt, Eric, Mcgovern, Dermot P B, Mokry, Michal, Nieuwenhuis, Edward, Clevers, Hans, Powrie, Fiona, Uhlig, Holm, Klein, Christoph, Muise, Aleixo, Dubinsky, Marla, and Snapper, Scott B

Published
2020

339. List of Contributors

Author

Albert, Réka, primary, Andrews, Brenda, additional, Bader, Gary D., additional, Ballance, Heather, additional, Barabási, Albert-László, additional, Barzel, Baruch, additional, Baryshnikova, Anastasia, additional, Bastiaens, Philippe I.H., additional, Benfey, Philip N., additional, Boone, Charles, additional, Brogaard, Kristin R., additional, Bulyk, Martha L., additional, Calderwood, Michael A., additional, Carvunis, Anne-Ruxandra, additional, Castrillo, Juan I., additional, Costanzo, Michael, additional, Cox, Jürgen, additional, Cusick, Michael E., additional, Davidson, Eric H., additional, Davis, Mark M., additional, Dekker, Job, additional, Flores, Mauricio A., additional, Fraser, Andrew, additional, Giaever, Guri, additional, Gonçalves, Bruno, additional, Grecco, Hernán E., additional, Guigó, Roderic, additional, Hefzi, Hooman, additional, Hein, Marco Y., additional, Hogenesch, John B., additional, Hood, Leroy, additional, Iyengar, Ravi, additional, Kitano, Hiroaki, additional, Kulkarni, Meghana M., additional, Lee, Anna Y., additional, Lehner, Ben, additional, Lemischka, Ihor, additional, Lewis, Nathan E., additional, Ma'ayan, Avi, additional, Mann, Matthias, additional, Mariottini, Chiara, additional, Myers, Chad L., additional, Nislow, Corey, additional, Novák, Béla, additional, Oliver, Stephen G., additional, Palsson, Bernhard O., additional, Papatsenko, Dmitri, additional, Peter, Isabelle S., additional, Perra, Nicola, additional, Perrimon, Norbert, additional, Pir, Pinar, additional, Price, Nathan D., additional, Roth, Frederick P., additional, Savageau, Michael A., additional, Schadt, Eric E., additional, Scheres, Ben, additional, Schmick, Malte, additional, Sharma, Amitabh, additional, Sharma, Kirti, additional, Shen-Orr, Shai S., additional, Sun, Zhongyao, additional, Superti-Furga, Giulio, additional, Tyson, John J., additional, VanderSluis, Benjamin, additional, van Steensel, Bas, additional, Venkataraman, Anand, additional, Vespignani, Alessandro, additional, Vidal, Marc, additional, Wagner, Andreas, additional, Walhout, A.J. Marian, additional, and Xu, Huilei, additional

Published
2013
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340. Improving Pre-eclampsia Risk Prediction by Modeling Individualized Pregnancy Trajectories Derived from Routinely Collected Electronic Medical Record Data

Author

Li, Shilong, primary, Wang, Zichen, additional, Vieira, Luciana A., additional, Zheutlin, Amanda B., additional, Ru, Boshu, additional, Schadt, Emilio, additional, Wang, Pei, additional, Copperman, Alan B., additional, Stone, Joanne, additional, Gross, Susan J., additional, Schadt, Eric E., additional, and Li, Li, additional

Published
2021
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341. Rare Germline Pathogenic Variants Identified by Multigene Panel Testing and the Risk of Aggressive Prostate Cancer

Author

Nguyen-Dumont, Tú, primary, Dowty, James G., additional, MacInnis, Robert J., additional, Steen, Jason A., additional, Riaz, Moeen, additional, Dugué, Pierre-Antoine, additional, Renault, Anne-Laure, additional, Hammet, Fleur, additional, Mahmoodi, Maryam, additional, Theys, Derrick, additional, Tsimiklis, Helen, additional, Severi, Gianluca, additional, Bolton, Damien, additional, Lacaze, Paul, additional, Sebra, Robert, additional, Schadt, Eric, additional, McNeil, John, additional, Giles, Graham G., additional, Milne, Roger L., additional, and Southey, Melissa C., additional

Published
2021
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342. Bayesian Model Infers Drug Repurposing Candidates for Treatment of COVID-19

Author

Kiebish, Michael A., primary, Shah, Punit, additional, Sarangarajan, Rangaprasad, additional, Vishnudas, Vivek K., additional, Gesta, Stephane, additional, Tekumalla, Poornima K., additional, Bountra, Chas, additional, Granger, Elder, additional, Schadt, Eric, additional, Rodrigues, Leonardo O., additional, and Narain, Niven R., additional

Published
2021
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343. A Drosophila platform identifies a novel, personalized therapy for a patient with adenoid cystic carcinoma

Author

Bangi, Erdem, primary, Smibert, Peter, additional, Uzilov, Andrew V., additional, Teague, Alexander G., additional, Gopinath, Sindhura, additional, Antipin, Yevgeniy, additional, Chen, Rong, additional, Hecht, Chana, additional, Gruszczynski, Nelson, additional, Yon, Wesley J., additional, Malyshev, Denis, additional, Laspina, Denise, additional, Selkridge, Isaiah, additional, Wang, Huan, additional, Gomez, Jorge, additional, Mascarenhas, John, additional, Moe, Aye S., additional, Lau, Chun Yee, additional, Taik, Patricia, additional, Pandya, Chetanya, additional, Sung, Max, additional, Kim, Sara, additional, Yum, Kendra, additional, Sebra, Robert, additional, Donovan, Michael, additional, Misiukiewicz, Krzysztof, additional, Ang, Celina, additional, Schadt, Eric E., additional, Posner, Marshall R., additional, and Cagan, Ross L., additional

Published
2021
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345. Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma

Author

Huang, Chen, primary, Chen, Lijun, additional, Savage, Sara R., additional, Eguez, Rodrigo Vargas, additional, Dou, Yongchao, additional, Li, Yize, additional, da Veiga Leprevost, Felipe, additional, Jaehnig, Eric J., additional, Lei, Jonathan T., additional, Wen, Bo, additional, Schnaubelt, Michael, additional, Krug, Karsten, additional, Song, Xiaoyu, additional, Cieślik, Marcin, additional, Chang, Hui-Yin, additional, Wyczalkowski, Matthew A., additional, Li, Kai, additional, Colaprico, Antonio, additional, Li, Qing Kay, additional, Clark, David J., additional, Hu, Yingwei, additional, Cao, Liwei, additional, Pan, Jianbo, additional, Wang, Yuefan, additional, Cho, Kyung-Cho, additional, Shi, Zhiao, additional, Liao, Yuxing, additional, Jiang, Wen, additional, Anurag, Meenakshi, additional, Ji, Jiayi, additional, Yoo, Seungyeul, additional, Zhou, Daniel Cui, additional, Liang, Wen-Wei, additional, Wendl, Michael, additional, Vats, Pankaj, additional, Carr, Steven A., additional, Mani, D.R., additional, Zhang, Zhen, additional, Qian, Jiang, additional, Chen, Xi S., additional, Pico, Alexander R., additional, Wang, Pei, additional, Chinnaiyan, Arul M., additional, Ketchum, Karen A., additional, Kinsinger, Christopher R., additional, Robles, Ana I., additional, An, Eunkyung, additional, Hiltke, Tara, additional, Mesri, Mehdi, additional, Thiagarajan, Mathangi, additional, Weaver, Alissa M., additional, Sikora, Andrew G., additional, Lubiński, Jan, additional, Wierzbicka, Małgorzata, additional, Wiznerowicz, Maciej, additional, Satpathy, Shankha, additional, Gillette, Michael A., additional, Miles, George, additional, Ellis, Matthew J., additional, Omenn, Gilbert S., additional, Rodriguez, Henry, additional, Boja, Emily S., additional, Dhanasekaran, Saravana M., additional, Ding, Li, additional, Nesvizhskii, Alexey I., additional, El-Naggar, Adel K., additional, Chan, Daniel W., additional, Zhang, Hui, additional, Zhang, Bing, additional, Agarwal, Anupriya, additional, Anderson, Matthew L., additional, Avanessian, Shayan C., additional, Avtonomov, Dmitry, additional, Bathe, Oliver F., additional, Birger, Chet, additional, Birrer, Michael J., additional, Blumenberg, Lili, additional, Bocik, William E., additional, Borate, Uma, additional, Borucki, Melissa, additional, Burke, Meghan C., additional, Cai, Shuang, additional, Calinawan, Anna Pamela, additional, Cerda, Sandra, additional, Charamut, Alyssa, additional, Chen, Lin S., additional, Chowdhury, Shrabanti, additional, Clauser, Karl R., additional, Culpepper, Houston, additional, Czernicki, Tomasz, additional, D'Angelo, Fulvio, additional, Day, Jacob, additional, De Young, Stephanie, additional, Demir, Emek, additional, Ding, Fei, additional, Domagalski, Marcin J., additional, Dort, Joseph C., additional, Druker, Brian, additional, Duffy, Elizabeth, additional, Dyer, Maureen, additional, Edwards, Nathan J., additional, Elburn, Kimberly, additional, Ermakova, Tatiana S., additional, Fenyo, David, additional, Ferrarotto, Renata, additional, Francis, Alicia, additional, Gabriel, Stacey, additional, Garofano, Luciano, additional, Geffen, Yifat, additional, Getz, Gad, additional, Goldthwaite, Charles A., additional, Hannick, Linda I., additional, Hariharan, Pushpa, additional, Hayes, David N., additional, Heiman, David, additional, Hindenach, Barbara, additional, Hoadley, Katherine A., additional, Hostetter, Galen, additional, Hyrcza, Martin, additional, Jewell, Scott D., additional, Jones, Corbin D., additional, Kane, M. Harry, additional, Karz, Alicia, additional, Kothadia, Ramani B., additional, Krek, Azra, additional, Kumar-Sinha, Chandan, additional, Liu, Tao, additional, Liu, Hongwei, additional, Ma, Weiping, additional, Malc, Ewa, additional, Malovannaya, Anna, additional, Mareedu, Sailaja, additional, Markey, Sanford P., additional, Marrero-Oliveras, Annette, additional, Maunganidze, Nicollette, additional, McDermott, Jason E., additional, McGarvey, Peter B., additional, McGee, John, additional, Mieczkowski, Piotr, additional, Migliozzi, Simona, additional, Montgomery, Rebecca, additional, Newton, Chelsea J., additional, Ozbek, Umut, additional, Paulovich, Amanda G., additional, Payne, Samuel H., additional, Pazardzhikliev, Dimitar Dimitrov, additional, Perou, Amy M., additional, Petralia, Francesca, additional, Petrenko, Lyudmila, additional, Piehowski, Paul D., additional, Placantonakis, Dmitris, additional, Polonskaya, Larisa, additional, Ponomareva, Elena V., additional, Potapova, Olga, additional, Qi, Liqun, additional, Qu, Ning, additional, Ramkissoon, Shakti, additional, Reva, Boris, additional, Richey, Shannon, additional, Robinson, Karna, additional, Roche, Nancy, additional, Rodland, Karin, additional, Rohrer, Daniel C., additional, Rykunov, Dmitry, additional, Schadt, Eric E., additional, Shi, Yan, additional, Shutack, Yvonne, additional, Singh, Shilpi, additional, Skelly, Tara, additional, Smith, Richard, additional, Sokoll, Lori J., additional, Stawicki, Jakub, additional, Stein, Stephen E., additional, Suh, James, additional, Szopa, Wojciech, additional, Tabor, Dave, additional, Tan, Donghui, additional, Tansil, Darlene, additional, Teo, Guo Ci, additional, Thangudu, Ratna R., additional, Tognon, Cristina, additional, Traer, Elie, additional, Tsang, Shirley, additional, Tyner, Jeffrey, additional, Um, Ki Sung, additional, Valley, Dana R., additional, Vasilev, Lyubomir Valkov, additional, Vatanian, Negin, additional, Velvulou, Uma, additional, Vernon, Michael, additional, Westbrook, Thomas F., additional, Whiteaker, Jeffrey R., additional, Wu, Yige, additional, Xu, Midie, additional, Yao, Lijun, additional, Yi, Xinpei, additional, Yu, Fengchao, additional, Zaalishvili, Kakhaber, additional, Zakhartsev, Yuriy, additional, Zelt, Robert, additional, Zhao, Grace, additional, and Zhu, Jun, additional

Published
2021
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346. Protective lipid-lowering genetic variants in healthy older individuals without coronary heart disease

Author

Lacaze, Paul, primary, Riaz, Moeen, additional, Sebra, Robert, additional, Hooper, Amanda J, additional, Pang, Jing, additional, Tiller, Jane, additional, Polekhina, Galina, additional, Tonkin, Andrew M, additional, Reid, Christopher M, additional, Zoungas, Sophia, additional, Murray, Anne M, additional, Nicholls, Stephen J, additional, Watts, Gerald F, additional, Schadt, Eric, additional, and McNeil, John J, additional

Published
2021
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347. Polygenic risk score for alcohol drinking behavior improves prediction of inflammatory bowel disease risk

Author

Di Narzo, Antonio F, primary, Hart, Amy, additional, Kosoy, Roman, additional, Peters, Lauren, additional, Stojmirovic, Aleksandar, additional, Cheng, Haoxiang, additional, Zhang, Zhongyang, additional, Shan, Mingxu, additional, Cho, Judy, additional, Kasarskis, Andrew, additional, Argmann, Carmen, additional, Peter, Inga, additional, Schadt, Eric E, additional, and Hao, Ke, additional

Published
2021
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348. Abstract PS7-04: Population-based estimates of breast cancer risk for germline pathogenic variants identified by gene-panel testing: An Australian perspective

Author

Nguyen-Dumont, Tu, primary, Dowty, James, additional, Tucker, Katherine, additional, Kirk, Judy, additional, James, Paul, additional, Trainer, Alison, additional, Winship, Ingrid, additional, Pachter, Nicholas, additional, Poplawski, Nicola, additional, Grist, Scott, additional, Park, Daniel J, additional, Renault, Anne-Laure, additional, Hammet, Fleur, additional, Mahmoodi, Maryam, additional, Tsimiklis, Helen, additional, Steen, Jason A, additional, Theys, Derrick, additional, Rewse, Amanda, additional, Willis, Amanda, additional, Morrow, April, additional, Speechly, Catherine, additional, Harris, Rebecca, additional, Riaz, Moeen, additional, Sebra, Robert, additional, Schadt, Eric, additional, Lacaze, Paul, additional, McNeil, John, additional, Hopper, John L, additional, and Southey, Melissa C, additional

Published
2021
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349. A Molecular network approach reveals shared cellular and molecular signatures between chronic fatigue syndrome and other fatiguing illnesses

Author

Comella, Phillip H., primary, Gonzalez-Kozlova, Edgar, additional, Kosoy, Roman, additional, Charney, Alexander W., additional, Peradejordi, Irene Font, additional, Chandrasekar, Shreya, additional, Tyler, Scott R., additional, Wang, Wenhui, additional, Losic, Bojan, additional, Zhu, Jun, additional, Hoffman, Gabriel E., additional, Kim-Schulze, Seunghee, additional, Qi, Jingjing, additional, Patel, Manishkumar, additional, Kasarskis, Andrew, additional, Suarez-Farinas, Mayte, additional, Gümüş, Zeynep H., additional, Argmann, Carmen, additional, Merad, Miriam, additional, Becker, Christian, additional, Beckmann, Noam D., additional, and Schadt, Eric E., additional

Published
2021
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350. An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease

Author

Cohain, Ariella T., primary, Barrington, William T., additional, Jordan, Daniel M., additional, Beckmann, Noam D., additional, Argmann, Carmen A., additional, Houten, Sander M., additional, Charney, Alexander W., additional, Ermel, Raili, additional, Sukhavasi, Katyayani, additional, Franzen, Oscar, additional, Koplev, Simon, additional, Whatling, Carl, additional, Belbin, Gillian M., additional, Yang, Jialiang, additional, Hao, Ke, additional, Kenny, Eimear E., additional, Tu, Zhidong, additional, Zhu, Jun, additional, Gan, Li-Ming, additional, Do, Ron, additional, Giannarelli, Chiara, additional, Kovacic, Jason C., additional, Ruusalepp, Arno, additional, Lusis, Aldons J., additional, Bjorkegren, Johan L. M., additional, and Schadt, Eric E., additional

Published
2021
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