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An archeomagnetic study has been performed for six archeological relics of the Proto-Three Kingdoms period excavated in Jungdo Island, South Korea. Among a total of 90 samples from hearths remains of six dwelling sites, the characteristic remanent magnetization components were isolated from 70 samples using the progressive alternating field demagnetizations and considered to record faithfully a thermoremanent magnetization at the timing of the last cooling of the hearths. Two different approaches were made to determine the archeomagnetic ages: One is the conventional method using the relocated paleosecular variation (PSV) curve obtained from southwestern Japan. The other method adopts a Matlab archaeo_dating tool using a Bayesian statistics with global geomagnetic field prediction model (ARCH3K.1). Both archeomagnetic ages using two individual dating methods generally overlapped with the radiocarbon age ranges for each sites. However, no systematic relationship between archeomagnetic ages and radiocarbon ages was observed, implying that neither the relocated Japanese PSV data nor the global model accurately represent the Korean secular variation during the archeological period of this study. At present, archeomagnetic dating in Korea should be carefully applied in conjunction with other dating methods on the consideration of archeological context. [ABSTRACT FROM AUTHOR]

This study protocol aims to explore the effectiveness, safety, and cost-effectiveness of a herbal medication, Gongjindan (GJD), in patients with chronic dizziness. This will be a prospective, multicenter, randomized, double-blind, placebo-controlled, parallel-group, clinical trial. Seventy-eight patients diagnosed with Meniere’s disease, psychogenic dizziness, or dizziness of unknown cause will be randomized and allocated to either a GJD or a placebo group in a 1 : 1 ratio. Participants will be orally given 3.75 g GJD or placebo in pill form once a day for 56 days. The primary outcome measure will be the Dizziness Handicap Inventory score. Secondary outcome measures will be as follows: severity (mean vertigo scale and visual analogue scale) and frequency of dizziness, balance function (Berg Balance Scale), fatigue (Fatigue Severity Scale) and deficiency pattern/syndrome (qi blood yin yang-deficiency questionnaire) levels, and depression (Korean version of Beck’s Depression Inventory) and anxiety (State-Trait Anxiety Inventory) levels. To assess safety, adverse events, including laboratory test results, will be monitored. Further, the incremental cost-effectiveness ratio will be calculated based on quality-adjusted life years (from the EuroQoL five dimensions’ questionnaire) and medical expenses. Data will be statistically analyzed at a significance level of 0.05 (two-sided). This trial is registered with ClinicalTrials.gov NCT03219515, in July 2017. [ABSTRACT FROM AUTHOR]

The advancement of software defined networking (SDN) is redefining traditional computer networking architecture. The role of the control plane of SDN is of such importance that SDNs are referred to as network operating systems (OSs). However, the robustness and security of the network OS has been overlooked. In this paper, we report three main issues pertaining to network OSs. First, we identified vulnerabilities that could be exploited by malicious or buggy applications running on network OSs. We also identified four major attack vectors that could undermine network OS operations: denial of service, global data manipulation, control plane poisoning, and system shell execution. Further, it was demonstrated that real-world attacks can be launched on commonly used network OSs without significant effort. Second, we present a method to address the attacks by analyzing network applications running on network OSs to identify their behavioral features, which enabled the extraction of a permission set for each network application. Based on this work, a permission-based malicious network application detector was introduced, which examines the permission set of each application and prevents it from executing without permission. Our system shows almost no performance overhead. Copyright © 2015 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Background: This study protocol evaluates the effectiveness of adjuvant electroacupuncture (EA) for urinary retention in poststroke patients undergoing conventional treatments, in comparison with that of a sham control.Methods/design: A multicenter, blinded, randomized controlled trial will be conducted in three hospitals in the Republic of Korea. We are recruiting 54 stroke survivors (aged >19 years), who were diagnosed with urinary retention based on the results of two consecutive post-void residual (PVR) tests, and dividing them randomly into two arms: the EA and Park-sham control groups. They will receive ten sessions of EA or sham treatment for 2 weeks. The participants will be blinded with non-penetrating needles and fake sounds of EA stimulators. The daily PVR ratio will be primarily measured at baseline and at the end of the study to statistically test the effectiveness of EA for poststroke urinary retention. Then, the Korean version of the Qualiveen Questionnaire, the Korean version of the International Prostate Symptom Score, and the blinding index will be assessed. After each EA session or sham EA, adverse events will be reported to evaluate the safety of EA. Results will be analyzed by using the independent t-test or Mann-Whitney U test, based on both intention-to-treat and per-protocol principles.Discussion: The findings will provide clinical evidence for the effectiveness of EA treatment to improve urinary retention in stroke survivors.Trial Registration: This study protocol was registered in ClinicalTrials.gov (NCT02472288) on 10 June 2015. [ABSTRACT FROM AUTHOR]

This paper presents a comprehensive analysis of the anisotropy of magnetic susceptibility (AMS) and paleomagnetic data from Quaternary basalt outcrops along the Hantangang River, Korea. A total of 554 samples were collected from 20 sites, representing three distinct units, Unit I, Unit II, and Unit III. Paleomagnetic data reveal a difference in the timing of eruptions between Units I and II, suggesting distinct periods by volcanic episodes. The mineral magnetic analysis identified titanomagnetite as the dominant magnetic carrier in the samples. AMS results indicated weak anisotropy and scattered AMS directions, indicating a low degree of preferred orientation of grains within the basalt rocks. The inverse AMS fabrics observed at specific sites are attributed to single-domain (SD) grains. Comparing the AMS data with the anisotropy of anhysteretic remanent magnetization (AARM) data, three distinct types of magnetic fabrics (normal, intermediate, and inverse) were discerned. The magnetic fabric was utilized to ascertain the flow direction based on the findings obtained from the AMS results. The findings suggest that the Quaternary basalts in this study's area were primarily confined to the Hantangang River channel and its immediate vicinity during lava flow. However, distinct flow patterns are observed in the southwestern region, implying the presence of unknown volcanic sources. [ABSTRACT FROM AUTHOR]

Optically stimulated luminescence (OSL) dating was performed on Late Quaternary deltaic sequences from a 55-m-long core sampled from the Nakdong River estuary, Korea. OSL ages obtained from chemically separated fine (4–11 μm) and coarse (90–212 μm) quartz grains ranged from 29.4 ± 2.6 to 0.4 ± 0.04 ka, revealing clear consistency between the grain-size fractions. The D e values from the standardized growth curve (SGC) are consistent with those from the single-aliquot regenerative-dose (SAR) procedure, which suggests that the SGC is valid for the Nakdong deltaic sediments. The 14 C ages of shells and wood fragments ranged from 11 to 2.9 ka, demonstrating reasonable agreement with the OSL ages, within the error range. However, the limited number and random sampling interval of the 14 C age data (10 ages) result in a simple linear and exponential trend in the depth–age curve. In contrast, OSL ages obtained by high-resolution sampling show down-section variations in the depth–age curve, indicating the occurrence of rapid changes in sedimentation rate. It is suggested that the high-sampling-resolution OSL ages provide a more realistic and detailed depth–age curve and sedimentation rate. The Nakdong deltaic sediments were divided into five units based on sedimentation rate. The lowest (unit 5) shows a break in sedimentation between the last glacial maximum (LGM) and the Holocene. The sedimentation rate increased in units 4 and 3, presumably corresponding to the early to middle Holocene sea level rise and high stand. Unit 2 shows a gradually decreasing sedimentation rate following the regression of the shoreline, until about 2 ka. The progradation of the Nakdong River delta resulted in the rapid accumulation of unit 1 during the last 2000 years. [ABSTRACT FROM AUTHOR]

Essential oils were extracted from the roots and leaves ofCnidium officinaleMakino (Umbelliferae) cultivated in three different districts of Korea. Extraction was carried out by steam distillation, and the composition of the essential oils was analyzed by gas chromatography–mass spectrometry (GC–MS). The extracted oils were compared between different samples. The antibacterial properties of the essential oils and their main components were determined against twelve antibiotic-susceptible or -resistant food-borne pathogenic bacteria. No distinct differences in composition of the essential oils from the rhizomes were found depending upon from which of the three districts the plant was cultivated. In contrast, their composition differed markedly depending on from which part of the plant the oil came, specifically the leaves versus the rhizomes. All of the essential oil fractions and their main component,Z-ligustilide, inhibited the growth of all of the bacterial strains tested, except forYersinia enterocolitica, and had minimum inhibiting concentrations (MICs) ranging from 0.5 to 4.0 mg/mL. In addition, the cell viability of Caco-2 and MKN-45 cancer cell lines was not altered following exposure to the oils at concentrations between 10 and 160 μg/mL. [ABSTRACT FROM PUBLISHER]