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5,205 results on '"Suzuki, Atsushi"'

309. Impact of the timing of first appropriate shock on outcomes in patients with an implantable cardioverter‐defibrillator: Early versus late

Author

Kishihara, Makoto, primary, Hattori, Hidetoshi, additional, Suzuki, Atsushi, additional, Kanai, Miwa, additional, Kataoka, Shohei, additional, Yazaki, Kyoichiro, additional, Kikuchi, Noriko, additional, Yagishita, Daigo, additional, Minami, Yuichiro, additional, Yamaguchi, Junichi, additional, Shoda, Morio, additional, and Hagiwara, Nobuhisa, additional

Published
2022
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327. Impact of B Cell Depletion on COVID-19 in Kidney Transplant Recipients.

Author

Aida, Naohiro, Ito, Taihei, Kurihara, Kei, Hiratsuka, Izumi, Shibata, Megumi, Suzuki, Atsushi, Hasegawa, Midori, and Kenmochi, Takashi

Subjects
B cells, KIDNEY transplantation, COVID-19, COVID-19 pandemic, BLOOD group incompatibility, COVID-19 treatment
Abstract

Kidney transplant recipients are patients at high risk for coronavirus disease 2019 (COVID-19) due to being on immunosuppressive therapy. B cell depletion therapy, including rituximab, is an important strategy for ABO-incompatible transplants. However, knowledge about the effect of B cell depletion therapy on COVID-19 is lacking. Thirty kidney transplant recipients who developed COVID-19 were included in this study. To examine the impact of B cell depletion therapy, we retrospectively investigated the relationship between the background of the patients and the clinical outcome. Of the 30 patients, 13 received B cell depletion therapy. The median time between transplant and onset of COVID-19 was 6.1 years after transplantation; however, nine cases remained markedly depleted of CD19(+) cells (<4.0%). The patients were assigned to the normal (n = 21) and depletion groups (n = 9). Progression rates in the depletion and normal groups were 55.6% and 9.5%, respectively (p = 0.014). Furthermore, the survival rate was significantly lower in the depletion group (100% in the normal group vs. 66.7% in the depletion group; p = 0.021). B cell depletion therapy may have long-term effects and increase the risk of COVID-19 in kidney transplant recipients. [ABSTRACT FROM AUTHOR]

Published
2023
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328. Effects of Co-Addition of Guanidinium and Cesium to CH 3 NH 3 PbI 3 Perovskite Solar Cells.

Author

Oku, Takeo, Uchiya, Shoma, Okumura, Riku, Suzuki, Atsushi, Ono, Iori, Fukunishi, Sakiko, Tachikawa, Tomoharu, and Hasegawa, Tomoya

Subjects
SOLAR cells, GUANIDINE, PHOTOVOLTAIC power systems, PEROVSKITE, LEAD iodide, DENSITY of states, CESIUM, CESIUM compounds
Abstract

The effects of guanidinium (C(NH2)3, GA) and cesium (Cs) co-additions on methylammonium lead iodide (CH3NH3PbI3, MAPbI3) perovskite solar cells were investigated. The first-principles calculations on the density of the states and band structures showed a reduction in the total energy by the GA addition. Although the calculation showed that the co-addition of the GA/Cs to the MAPbI3 perovskite could decrease the carrier mobilities, and the addition of GA/Cs improved the device performance. This result would be due to a facilitation of grain growth and a suppression of the defects from the GA/Cs addition. The changes to the conversion efficiencies of the device with the best performance were small, which indicates that the present co-addition of GA/Cs is effective for the stability of the devices. [ABSTRACT FROM AUTHOR]

Published
2023
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329. Secretory GFP reconstitution labeling of neighboring cells interrogates cell–cell interactions in metastatic niches.

Author

Minegishi, Misa, Kuchimaru, Takahiro, Nishikawa, Kaori, Isagawa, Takayuki, Iwano, Satoshi, Iida, Kei, Hara, Hiromasa, Miura, Shizuka, Sato, Marika, Watanabe, Shigeaki, Shiomi, Akifumi, Mabuchi, Yo, Hamana, Hiroshi, Kishi, Hiroyuki, Sato, Tatsuyuki, Sawaki, Daigo, Sato, Shigeru, Hanazono, Yutaka, Suzuki, Atsushi, and Kohro, Takahide

Abstract

Cancer cells inevitably interact with neighboring host tissue-resident cells during the process of metastatic colonization, establishing a metastatic niche to fuel their survival, growth, and invasion. However, the underlying mechanisms in the metastatic niche are yet to be fully elucidated owing to the lack of methodologies for comprehensively studying the mechanisms of cell–cell interactions in the niche. Here, we improve a split green fluorescent protein (GFP)-based genetically encoded system to develop secretory glycosylphosphatidylinositol-anchored reconstitution-activated proteins to highlight intercellular connections (sGRAPHIC) for efficient fluorescent labeling of tissue-resident cells that neighbor on and putatively interact with cancer cells in deep tissues. The sGRAPHIC system enables the isolation of metastatic niche-associated tissue-resident cells for their characterization using a single-cell RNA sequencing platform. We use this sGRAPHIC-leveraged transcriptomic platform to uncover gene expression patterns in metastatic niche-associated hepatocytes in a murine model of liver metastasis. Among the marker genes of metastatic niche-associated hepatocytes, we identify Lgals3, encoding galectin-3, as a potential pro-metastatic factor that accelerates metastatic growth and invasion.Methodologies to study the mechanisms of cell–cell interactions in metastatic niches remain scarce. Here, the authors develop a secretory GFP reconstitution-based system to tag tissue-resident cells neighboring on cancer cells within the metastatic niche. [ABSTRACT FROM AUTHOR]

Published
2023
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335. Association of dipeptidyl peptidase‐4 inhibitor use and risk of pancreatic cancer in individuals with diabetes in Japan

Author

Kubota, Sodai, primary, Haraguchi, Takuya, additional, Kuwata, Hitoshi, additional, Seino, Yusuke, additional, Murotani, Kenta, additional, Tajima, Takumi, additional, Terashima, Gen, additional, Kaneko, Makiko, additional, Takahashi, Yoshihiro, additional, Takao, Ken, additional, Kato, Takehiro, additional, Shide, Kenichiro, additional, Imai, Saeko, additional, Suzuki, Atsushi, additional, Terauchi, Yasuo, additional, Yamada, Yuichiro, additional, Seino, Yutaka, additional, and Yabe, Daisuke, additional

Published
2022
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337. BMP3b Is a Novel Antifibrotic Molecule Regulated by Meflin in Lung Fibroblasts

Author

Suzuki, Atsushi, primary, Sakamoto, Koji, additional, Nakahara, Yoshio, additional, Enomoto, Atsushi, additional, Hino, Jun, additional, Ando, Akira, additional, Inoue, Masahide, additional, Shiraki, Yukihiro, additional, Omote, Norihito, additional, Kusaka, Masahiro, additional, Fukihara, Jun, additional, and Hashimoto, Naozumi, additional

Published
2022
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342. Stratification of Destination Therapy Candidates by J-HeartMate Risk Score Among Elderly Non-Responders to Cardiac Resynchronization Therapy

Author

Yoshimura, Asami, primary, Kikuchi, Noriko, additional, Saito, Satoshi, additional, Suzuki, Atsushi, additional, Hattori, Hidetoshi, additional, Shoda, Morio, additional, Ichihara, Yuki, additional, Niinami, Hiroshi, additional, Hagiwara, Nobuhisa, additional, Yamaguchi, Junichi, additional, and Nunoda, Shinichi, additional

Published
2022
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345. Combination of high-sensitivity troponin I and N-terminal pro-B-type natriuretic peptide predicts future hospital admission for heart failure in high-risk hypertensive patients with preserved left ventricular ejection fraction

Author

Okuyama, Ryunosuke, Ishii, Junnichi, Takahashi, Hiroshi, Kawai, Hideki, Muramatsu, Takashi, Harada, Masahide, Yamada, Akira, Motoyama, Sadako, Matsui, Shigeru, Naruse, Hiroyuki, Sarai, Masayoshi, Hasegawa, Midori, Watanabe, Eiichi, Suzuki, Atsushi, Hayashi, Mutsuharu, Izawa, Hideo, Yuzawa, Yukio, and Ozaki, Yukio

Published
2017
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