Search

The fault diagnosis of axial piston pumps is of significance for enhancing the reliability and security of hydraulic systems. Most of the faults occurring in the mechanical components of piston pumps are exhibited as fault-excited impulses. However, the strong impact-induced natural periodic impulses under the common working conditions (i.e. reciprocating motion of pistons) inevitably cause interference that considerably affects the fault detection performance. In this study, a simulation-determined band pass filter is employed to improve the performance of minimum entropy deconvolution (MED) for the fault diagnosis of axial piston pump bearings. First, a finite element method (FEM) simulation is performed to determine the possible carrier frequency. Second, the carrier frequency is used as the center frequency in association with a fixed bandwidth to determine the band pass filter parameters. Finally, the MED technique is applied to enhance weak fault-excited impulses by means of kurtosis maximization. Thereafter, envelope spectrum analysis is applied to the enhanced signals to obtain faulty feature frequencies. Two case studies are conducted, using bearings with faults in the outer and inner races of an axial piston pumps under common working conditions. The case studies confirm the necessity and effectiveness of the proposed method for detecting bearings faults in axial piston pumps., (Copyright © 2018 ISA. Published by Elsevier Ltd. All rights reserved.)

A new compound 2-(4-((2-butyl-5-nitro-1H-benzo[d]imidazol-1-yl)methyl)-1H-indol-1-yl) benzamide (1) was designed, synthesized and evaluated as a novel AT1 receptor antagonist. Compound 1 displayed high affinity to AT1 receptor with an IC50 value of 1.65 ± 0.2 nM in radio-ligand binding assays. It had an efficient and long-lasting effect in reducing blood pressure which could last for more than 12 h at the dose of 10 mg/kg in spontaneously hypertensive rats. Acute toxicity tests suggested that compound 1 was safe with the LD50 value of 2519.81 mg/kg. Besides, in vitro and in vivo tests suggested its anti-proliferative and anti-tumor activities, respectively. So compound 1 could be considered as a novel anti-hypertension, anti-tumor candidate and deserved further investigation.