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HIV has significantly altered the face of healthcare and the lives of virtually everyone in our communities. The risk of transmission, particularly through needlestick injuries, continues to be a major concern for all of us working in healthcare services. Dr Thurn reviews new information about modes of HIV transmission, ways to reduce risks, and guidelines for managing exposures, should they occur.

Very little data obtained in a prospective, controlled fashion examines the prevalence of colonization with antibiotic-resistant bacteria and yeast in nursing home residents on admission to acute-care hospitals. We cultured swabs taken from all nursing home patients admitted to a medical center on selected days of the week. Age-matched control patients were also enrolled. Nasal, pharyngeal, and rectal or perineal swabs were done within 24 h of admission. Susceptibility to gentamicin was used as a marker for antibiotic resistance. Most nursing home patients (45/56) were colonized with gentamicin-resistant isolates of coagulase-negative staphylococci; in the control group, 24 patients only carried these organisms (P = 0.0001 chi square). The only resistant Gram-negative bacteria were recovered from control patients (3/56 vs. 0/56 nursing home residents; P = 0.12, Fisher's exact test). Yeast were common colonizers of both nursing home residents and controls but were more frequently recovered from nursing home patients (P = 0.03, chi square). Although colonization by antibiotic-resistant staphylococci of nursing home residents on admission to an acute-care hospital was common, resistant Gram-negative bacilli were not found in this study. Additional investigations are needed to determine the risk of infection/ colonization with resistant organisms in this population.

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The human immunodeficiency virus (HIV) has resulted in a worldwide pandemic of infection. By 1991 more than 350,000 AIDS cases had been reported to the World Health Organization, but it is estimated that there are now more than 10 million people infected worldwide. HIV can rapidly spread in new populations: The pandemic is composed of multiple smaller epidemics. In the United States, it is estimated that over a million people are infected with HIV. Methods of estimating this number include extrapolation from the number of reported cases of AIDS, use of mathematical modeling and back-calculation, and seroprevalence surveys. Minorities continue to be overrepresented among those infected, and the prevalence of HIV in women is increasing. In serosurveys, it has been found that as HIV prevalence rates rise, the ratio of infected males to infected females approaches 1:1, suggesting an increased proportion of hetero-sexual transmission. HIV is now variably present but widespread across the United States. The epidemiology of HIV-related illnesses is also changing, as can be seen with current patterns of tuberculosis. HIV continues to be an increasingly complex and dangerous global burden.

Because there is little information about the frequency of carriage of various species of coagulase-negative staphylococci (CNS) in hospital staff, we prospectively investigated nasal CNS in patients and personnel in a Surgical Intensive Care Unit (SICU). The majority of CNS from personnel were Staphylococcus epidermiditis. The CNS species from patients on admission were more diverse and included multiply antibiotic-resistant S. haemolyticus. Patients' CNS became more like CNS colonizing personnel after admission with respect to both antimicrobial susceptibility and speciation. Plasmid and antibiotic sensitivity profiles of S. epidermidis resistant to multiple antibiotics from five patients were identified as those from one employee, but there was no evidence that this was of clinical significance. A variety of factors influence nasal colonization by CNS in SICUs. The nasal CNS of patients change after admission and may become more resistant and less diverse. The factors influencing changes in the antibiotic susceptibility and the aetiology of CNS infection require further study.

Objective: To assess the experience of Minnesota nursing homes with methicillin-resistant Staphylococcus aureus (MRSA) and the policies and procedures used for its control., Design: A 12-question survey, with primarily categorical responses, was mailed to the Directors of Nursing of all Minnesota long-term-care facilities. A follow-up mailing was sent to non-responders 5 weeks later. The mailing included a cover letter, a description of the study and its purposes, and a stamped return envelope. Four weeks after the second mailing, all non-responding institutions were contacted by telephone and invited to participated by mail or by completing the survey by telephone., Setting: All long-term-care facilities in Minnesota licensed for skilled and intermediate care., Participants: The survey was directed to the Directors of Nursing of the long-term-care facilities with the request that, if another individual was better able to complete it, the survey be forwarded to them., Results: Completed responses were obtained from 88% (395/445) of all long-term-care facilities in Minnesota. Forty-eight institutions (12%) had residents colonized or infected with MRSA. Only four (8%) of these facilities stated that MRSA was a problem; however, 33 (69%) of facilities with MRSA had sought outside help or consultation from a variety of sources for its control. Few facilities (7%) had cultured residents specifically for MRSA. Policies regarding the admission of colonized or infected persons were reported by 14% and 21% of facilities, respectively, and over 40% of these policies stated that persons with MRSA would not be accepted. Policies regarding the care of MRSA-colonized or -infected persons were not uniform. Both metropolitan and non-metropolitan facilities had residents with MRSA., Conclusions: Our results suggest that MRSA in long-term-care facilities may be a widespread and underrecognized problem. There is a need to develop uniform policies for the control of MRSA in nursing homes. These policies should consider the sources and objectives of long-term-care facilities.

Healthcare workers know that there is a risk of HIV infection through exposure to AIDS patients. In both hospital and office settings, physicians have the opportunity to set standards and promote education about the degree of risk, effective precautions, and postexposure testing, prophylaxis, and treatment. Drs Henry and Thurn share the latest findings and offer policy recommendations based on their own experience.

We examined needle use and disposal, needlestick injuries and their management, and employee education regarding the acquired immunodeficiency syndrome and needle use by means of a questionnaire sent to all long-term care facilities certified for skilled care in Minnesota. Responses were received from 297 of 349 (85.1%) homes. Nearly all homes (271 of 293; 92.5%) provided education for new nursing employees about use and disposal of needles. Disposal of needles and sharps was generally consistent with current recommendations for short-term care hospitals. Needlestick injuries were usually related to recapping and were most common in registered and licensed practical nurses but were infrequent (i.e., less than 1 injury per home per employee-year) probably because parenteral therapy is infrequently used in long-term care settings. Only slightly over half (166 of 286; 58%) of the homes had protocols for management of needlestick injuries. Although Minnesota nursing homes properly dispose of needles and sharps, many of these institutions need to develop policies for management of needlestick injuries that are consistent with current recommendations.

Considerable progress has been made in the identification and treatment of Pneumocystis carinii pneumonia related to acquired immunodeficiency syndrome (AIDS). Prophylaxis, either primary or secondary, represents a major advance and should be used appropriately by physicians caring for patients infected with human immunodeficiency virus. Yet with success come new challenges. Centers for treatment of AIDS that aggressively use prophylaxis have seen a shift toward severe illness due to other pathogens and generalized wasting. The strategies employed in combating P carinii pneumonia are likely to be tried against other AIDS-related infections.

Septic shock is a difficult and complex condition that requires a thorough and thoughtful approach in all aspects of care. The most likely cause may become apparent by considering the clinical presentation of the patient and information from the history, physical examination, and appropriate laboratory tests. Appropriate antibiotic therapy should be initiated as soon as possible. Only an aggressive diagnostic and therapeutic approach can reduce the mortality and morbidity of this condition.

Although D-lactate is not a product of human intermediary metabolism, absorption of D-lactate produced by abnormal intestinal bacteria can cause systemic acidosis in patients who have undergone gastrointestinal surgery, particularly jejunoileal bypass. In order to learn more about the prevalence of D-lactate encephalopathy, its occurrence in other disorders, and how well D-lactate concentration correlates with clinical symptoms, serum D-lactate levels were determined in several specific populations. D-lactate was undetectable (less than 0.5 mmol/liter) in 72 healthy volunteers and 57 obese persons. In 33 patients who had jejunoileal bypass, 16 reported symptoms consistent with D-lactate encephalopathy since surgery. Nine of these 16 had D-lactate levels greater than 0.5 mmol/liter (range 0.7 to 11.5 mmol/liter). Levels of D-lactate fluctuated over time, and in two patients, markedly elevated levels correlated with an encephalopathy accompanied by hyperchloremic metabolic acidosis and elevated anion gap. In 470 randomly chosen hospitalized patients, D-lactate level greater than 0.5 mmol/liter was found in 13 (2.8 percent), and 60 percent of these had a history of gastrointestinal surgery or disease. It is concluded that elevated serum D-lactate levels are relatively common in patients with jejunoileal bypass, and although more rare, occur in other gastrointestinal disorders as well. The symptoms of D-lactate encephalopathy are quite sensitive, but not necessarily specific for this disorder.

Influenza A results in considerable morbidity, mortality and economic costs. Although immunoprophylaxis and chemoprophylaxis are targeted toward high-risk groups, persons with human immunodeficiency virus (HIV) infection have not been widely recognized as being at increased risk of influenza infection. We report a case of influenza A pneumonitis in a patient infected with HIV. The literature on influenza immunization of HIV-infected patients is reviewed and the implications for public health are discussed. Consideration should be given to influenza immunization and chemoprophylaxis in this enlarging population. Further investigation of the pathogenesis and epidemiology of influenza in HIV-infected patients is warranted.

Pulmonary infection acquired in nursing homes has not been extensively studied. Those data that have been published about the frequency and nature of nursing home-associated pneumonias are reviewed here. It remains unclear whether or not these institutionally-acquired pneumonias differ significantly from those that would occur in an age-matched control group with community-acquired infection. Viral pneumonias are recognized as significant causes of morbidity in the elderly.

Human parvovirus B19 has been associated with disease only for the past few years. First isolated from sera obtained for studies on hepatitis B in 1975, it was not until 1981 that infection with this small, single-stranded DNA virus was related to aplastic crisis associated with hemolytic anemia. A nonspecific viral prodrome, the occurrence in family members, and epidemics of aplastic crisis suggested the infectious etiology. Human parvovirus infection has since been associated with arthritis, erythema infectiosum (fifth disease), fetal death, and hydrops fetalis. Through the use of recently developed serologic tests, epidemics of erythema infectiosum and parvoviral infection have been related not only to aplastic crisis but also to intrauterine infection and hydrops; DNA hybridization studies have allowed the detection of viral DNA in serum and tissue extracts. Studies have been hampered by the lack of an ability to culture the virus, but this is now possible utilizing bone marrow culture and erythropoietin. This article is a historical and clinical review of human parvovirus infection and disease and considers potential questions regarding their consequences.

Because little is known about needlestick injury and needle disposal in non-hospital settings, we surveyed physicians' offices in Minnesota. Recapping of needles was frequent (51.1%, 72 of 141) and injuries had occurred during the past year in 44.0% of offices. When of known cause, needlesticks were most common during blood drawing and recapping (52.0%, 13 of 25). Small offices more often recapped needles, but only metropolitan small offices reported more frequent injuries. Only 37.6% of offices used a protocol for management of injuries, and in less than half (45.4%) was physician evaluation routine. Although most offices used plastic containers and a majority (73.0%) incinerated or autoclaved needles prior to disposal, small offices more often disposed of sharps in their routine solid waste. Larger metropolitan offices more consistently followed current recommendations for handling and disposing of needles. There is a need for education efforts to address these issues for physicians and their office staff.