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Circular RNA circSLC8A1 is one of the cancer-related circRNAs that is implicated in various cancers. However, studies focusing on the role of circSLC8A1 in glioma is rare. Here we attempted to evaluate the biological function of circSLC8A1 in glioma and explore the potential mechanism. The relative expression of circSLC8A1, miR-214-5p and CDC27 in tissues and cell lines was determined by qRT-PCR. Cell proliferation and invasion were respectively measured by CCK-8 and transwell assays. Protein level of CDC27 was analyzed by western blot. Luciferase reporter assay was performed to confirm the regulatory interaction of cirRNA-miRNA-mRNA. Lowly expressed circSLC8A1 was observed in both glioma tissues and cell lines. Further biological analyses showed that circSLC8A1 inhibits the cell proliferation and invasion of glioma cells. CircSLC8A1 directly sponged miR-214-5p and inhibited miR-214-5p expression in glioma cells. CDC27 was a direct target of miR-214-5p and could be regulated by miR-214-5p. Moreover, miR-214-5p mimics and CDC27 knockdown reversed the inhibitory effects of circSLC8A1 on cell proliferation and invasion. Taken together, our results demonstrated a tumor suppressive role of circSLC8A1 in glioma through regulation of glioma cells proliferation and invasion. The effects of circSLC8A1 were mediated by miR-214-5p/CDC27 axis. Our study provided a new understanding of the occurrence and development of glioma., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Skywave refers to the electromagnetic wave reflected or refracted from the ionosphere and propagated in the form of a guided wave between the ionosphere and the Earth's surface. Since the skywave can propagate over large distances, it has been widely used in long-distance communication. This paper explores and demonstrates the feasibility of skywave for deep resource and energy exploration at depths of up to 10 km. Theoretical and technical advancements were accomplished in furthering skywave applications. A new solution method based on Green's function has been developed to study skywave propagation in a fully coupled lithosphere-air-ionosphere full space model. For the first time, the model allows one to study skywave distribution characteristics in the lithosphere containing inhomogeneity such as ore deposits or oil and gas reservoirs. This model also lays a foundation for skywave data processing and interpretation. On a parallel line, we have developed a multi-channel, broadband, low-noise, portable data acquisition system suitable for receiving skywave signals. Using the skywave field excited by a high-power fixed source located in central China, actual field surveys have been carried out in some areas in China including the Biyang depression of Henan Province. The initial results appear encouraging-the interpreted resistivity models prove to be consistent with those of seismic exploration and known geological information, and the exploration cost is only ∼1/4 to 1/10 that of seismic surveys. These initial successful applications of the skywave theory lay a solid foundation for further verification of the new method., (© The Author(s) 2021. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd.)

Background: Local recurrence is the most difficult postoperative challenge and the leading cause of death in patients with retroperitoneal liposarcoma (RLPS). We aimed to establish a postoperative nomogram exclusively focused on RLPS for predicting local recurrence-free survival (LRFS)., Methods: A cohort of 124 patients after surgical resection with curative intent in the Peking University Cancer Hospital Sarcoma Center were included in the study. Demographic, clinicopathologic, and treatment variables were analyzed using the Cox regression model. Significant clinically relevant variables in multivariable analysis were incorporated into the RLPS-specific nomogram. The discriminative ability and predictive accuracy of the nomogram were assessed by calculating the concordance index and drawing a calibration plot., Results: At a median follow-up of 26.5 (interquartile range 10.9-39.4) months, 71 patients had recurrent disease. The 3-year and 5-year LRFS rates were 35.6% (95% confidence interval, 27.0-46.9%) and 28.2% (95% CI 15.8-38.6%), respectively. Multivariate analysis identified the French Federation of Cancer Centers Sarcoma Group (FNCLCC) grade and completeness of resection as independent predictors of LRFS. Variables included in our nomogram were: presentation status, multifocality, completeness of resection, histologic subtypes, and FNCLCC grade. The concordance index of our nomogram was 0.732 (95% CI 0.667-0.797) and the calibration plot was excellent., Conclusions: Our novel nomogram for patients with resected RLPS could improve recurrence risk stratification to explore molecular analysis associated with recurrence.

Competing Interests: Conflict of interest The authors declare that they have no conflict of interest.