Search

During the operation of landfills, leachate recirculation and aeration are widely applied to accelerate the waste stabilization process. However, these strategies may induce high pore pressures in waste, thereby affecting the stability of the landfill slope. Therefore, a three-dimensional numerical analysis for landfill slope stability during leachate recirculation and aeration is performed in this study using strength reduction method. The bio-hydro coupled processes of waste are simulated by a previously reported landfill coupled model programmed on the open-source platform OpenFOAM and then incorporated into the slope stability analysis. The results show that both increasing the injection pressure for leachate recirculation and maximum anaerobic biodegradation rate will reduce the factor of safety (FS) of the landfill slope maximally by 0.32 and 0.62, respectively, due to increased pore pressures. The ignorance of both waste biodegradation and gas flow will overestimate the slope stability of an anaerobic bioreactor landfill by about 20–50%, especially when the landfilled waste is easily degradable. The FS value of an aerobic bioreactor landfill slope will show a significant reduction (maximally by 53% in this study) when the aeration pressure exceeds a critical value and this value is termed as the safe aeration pressure. This study then proposes a relationship between the safe aeration pressure and the location of the air injection screen (i.e., the horizontal distance between the top of the injection screen and the slope surface) to avoid landfill slope failure during aeration. The findings of this study can provide insights for engineers to have a better understanding of the slope stability of a bioreactor landfill and to design and control the leachate recirculation and aeration systems in landfills. [ABSTRACT FROM AUTHOR]

Speaker recognition is a task of identifying persons from their voices. Recently, deep learning has dramatically revolutionized speaker recognition. However, there is lack of comprehensive reviews on the exciting progress. In this paper, we review several major subtasks of speaker recognition, including speaker verification, identification, diarization, and robust speaker recognition, with a focus on deep-learning-based methods. Because the major advantage of deep learning over conventional methods is its representation ability, which is able to produce highly abstract embedding features from utterances, we first pay close attention to deep-learning-based speaker feature extraction, including the inputs, network structures, temporal pooling strategies, and objective functions respectively, which are the fundamental components of many speaker recognition subtasks. Then, we make an overview of speaker diarization, with an emphasis of recent supervised, end-to-end, and online diarization. Finally, we survey robust speaker recognition from the perspectives of domain adaptation and speech enhancement, which are two major approaches of dealing with domain mismatch and noise problems. Popular and recently released corpora are listed at the end of the paper. [ABSTRACT FROM AUTHOR]

Retinoid X receptors are members of the nuclear receptor family that regulate gene expression in response to retinoic acid and related ligands. Group 1 metabotropic glutamate receptors are G-protein coupled transmembrane receptors that activate intracellular signaling cascades in response to the neurotransmitter, glutamate. These two classes of molecules have been studied independently and found to play important roles in regulating neuronal physiology with potential clinical implications for disorders such as depression, schizophrenia, Parkinson's and Alzheimer's disease. Here we show that mice lacking the retinoid X receptor subunit, RXRγ, exhibit impairments in group 1 mGluR-mediated electrophysiological responses at hippocampal Schaffer collateral-CA1 pyramidal cell synapses, including impaired group 1 mGluR-dependent long-term synaptic depression (LTD), reduced group 1 mGluR-induced calcium release, and loss of group 1 mGluR-activated voltage-sensitive currents. These animals also exhibit impairments in a subset of group 1 mGluR-dependent behaviors, including motor performance, spatial object recognition, and prepulse inhibition. Together, these observations demonstrate convergence between the RXRγ and group 1 mGluR signaling pathways that may function to coordinate their regulation of neuronal activity. They also identify RXRγ as a potential target for the treatment of disorders in which group 1 mGluR signaling has been implicated. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of coronary calcification morphology and severity on the diagnostic performance of machine learning (ML)–based coronary CT angiography (CCTA)–derived fractional flow reserve (CT-FFR) with FFR as a reference standard. Methods: A total of 442 patients (61.2 ± 9.1 years, 70% men) with 544 vessels who underwent CCTA, ML-based CT-FFR, and invasive FFR from China multicenter CT-FFR study were enrolled. The effect of calcification arc, calcification remodeling index (CRI), and Agatston score (AS) on the diagnostic performance of CT-FFR was investigated. CT-FFR ≤ 0.80 and lumen reduction ≥ 50% determined by CCTA were identified as vessel-specific ischemia with invasive FFR as a reference standard. Results: Compared with invasive FFR, ML-based CT-FFR yielded an overall sensitivity of 0.84, specificity of 0.94, and accuracy of 0.90 in a total of 344 calcification lesions. There was no statistical difference in diagnostic accuracy, sensitivity, or specificity of CT-FFR across different calcification arc, CRI, or AS levels. CT-FFR exhibited improved discrimination of ischemia compared with CCTA alone in lesions with mild-to-moderate calcification (AUC, 0.89 vs. 0.69, p < 0.001) and lesions with CRI ≥ 1 (AUC, 0.89 vs. 0.71, p < 0.001). The diagnostic accuracy and specificity of CT-FFR were higher than CCTA alone in patients and vessels with mid (100 to 299) or high (≥ 300) AS. Conclusion: Coronary calcification morphology and severity did not influence diagnostic performance of CT-FFR in ischemia detection, and CT-FFR showed marked improved discrimination of ischemia compared with CCTA alone in the setting of calcification. Key Points: • CT-FFR provides superior diagnostic performance than CCTA alone regardless of coronary calcification. • No significant differences in the diagnostic performance of CT-FFR were observed in coronary arteries with different coronary calcification arcs and calcified remodeling indexes. • No significant differences in the diagnostic accuracy of CT-FFR were observed in coronary arteries with different coronary calcification score levels. [ABSTRACT FROM AUTHOR]

Purpose: To measure the projection of the most anterior line of the spinal canal on lateral radiographs of the vertebra (C3–L5) and evaluate the efficacy of the safety line (SL) in preventing intraspinal cement leakage in percutaneous kyphoplasty (PKP) and percutaneous vertebroplasty (PVP). Materials and Methods: Fifteen adult dry-bone spine specimens were analyzed. The projection of the SL was viewed on lateral radiographs. The distance between the SL and the posterior vertebral body line (PVBL) was measured. Two groups of patients were treated by PKP, and cement injection was stopped either before the PBVL (group 1) or before the SL (group 2) under lateral fluoroscopy. The rate of cement leakage was compared between the two groups. Results: The largest distance between the SL and PVBL was at L1 (5.22 ± 0.62 mm). From L1 to L5, the distance decreased progressively to 1.05 ± 0.64 mm. Similar variation was also observed from L1 to T1 (0.19 ± 0.18 mm). The postoperative computed tomography scan was more sensitive and accurate in detecting intraspinal leakage than radiography in group 1 (p = 0.000); however, there was no significant difference in sensitivity or accuracy between methods in group 2 (p = 0.063). The rate of intraspinal cement leakage was significantly higher in group 1 than group 2 (p = 0.000). Conclusions: The operator should frequently check to ensure that cement injection has stopped upon reaching the SL. Surgeons may benefit from this quantitative anatomical study of PKP and PVP. [ABSTRACT FROM AUTHOR]